Read by QxMD icon Read

Work load

Petr Kolosov, Viviane Yargeau
Calcium-silicate mineral Polonite® and aluminum-based catalyst (AL-1010S), previously identified as promising materials for catalytic ozonation, were used as catalysts to investigate the impact of some operating conditions (ratio ozone feed concentration to catalyst load) and wastewater characteristics (chemical oxygen demand - COD and nitrite - NO2 concentration) on the disinfection and removal of contaminants of emerging concern (CECs) during catalytic ozonation of wastewater. Tests conducted in synthetic wastewater using two different ozone gas concentration (4 and 8 g (nm3 )) and 6 different catalyst loads provided ratios of 0...
October 2, 2018: Science of the Total Environment
Ainhoa Rubio-Clemente, Edwin Chica, Gustavo Peñuela
The presence of pathogens in drinking water can seriously affect human health. Therefore, water disinfection is needed, but conventional processes, such as chlorination, result in the production of dangerous disinfection by-products. In this regard, an alternative solution to tackle the problem of bacterial pollution may be the application of advanced oxidation processes. In this work, the inactivation of total coliforms, naturally present in a Colombian surface water by means of UV/H2 O2 , UV/US, and the UV/US/H2 O2 advanced oxidation processes, was investigated...
October 16, 2018: Environmental Science and Pollution Research International
Nicolas Alejandre-Alba, Rocio Gutierrez-Contreras, Carlos Dorronsoro, Susana Marcos
Purpose: Accommodating intraocular lenses (A-IOLs) require capturing the ciliary muscle forces. Prior work demonstrated strong photo-initiated bonding between strips of capsular bag and poly(2-hydroxyethyl methacrylate); (pHEMA) polymer in an extraocular setting. We demonstrate that photobonding can be achieved intraocularly. Methods: Phacoemulsification was performed in porcine eyes (<24 hours postmortem). A commercial intraocular lens (IOL; pHEMA-MMA material) was inserted in the capsular bag...
September 2018: Translational Vision Science & Technology
Rasha A AbuMousa, Umair Baig, Mohammed A Gondal, Mohamad S AlSalhi, Fulwah Yahya Alqahtani, Sultan Akhtar, Fadilah Sfouq Aleanizy, Mohamed A Dastageer
Chemotherapy, the most commonly used therapeutic method for cancer, has the inherent constraint of low bioavailability. A number of physical cancer therapeutic treatments like radiation, ultrasound, photo-acoustic/photo thermal, microwave therapies are based on locating the afflicted sites with the help of imaging, but the serious drawbacks of these treatment options are that they damage the neighboring normal tissues and/or induce undesired cancer metastasis. In addition, these methods of treatment are very expensive and not in the reach of a common man especially in the developing countries...
October 15, 2018: Scientific Reports
Rafael Moreno, Carlos Alberto Fajardo, Marti Farrera-Sal, Ana Judith Perisé-Barrios, Álvaro Morales-Molina, Ahmed Abdullah Al-Zaher, Javier Garcia-Castro, Ramon Alemany
Several studies have evaluated the efficacy of using human oncolytic adenovirus-loaded mesenchymal stem cells for cancer treatment. For example, we have described the antitumor efficacy of CELYVIR, autologous bone marrow mesenchymal stem cells infected with the oncolytic adenovirus ICOVIR-5, for treatment of neuroblastoma patients. Results from this clinical trial point out the role of the immune system in the clinical outcome. In this context, a better understanding of the immunophenotypic changes of human mesenchymal stem cells upon adenoviral infection and how these changes affect human autologous or allogeneic peripheral blood mononuclear cells (PBMCs) could guide strategies to improve the antitumor efficacy of infected Mesenchymal Stem Cells (MSCs)...
October 15, 2018: Molecular Cancer Therapeutics
Amrutlal L Prajapat, Parag R Gogate
In the present work, hydrodynamic cavitation (HC) has been used for the depolymerization of sodium salt of carboxymethyl cellulose (CMC) solution. Use of two different cavitating devices as slit and circular venturi has been investigated along with the combination of HC with potassium persulfate (KPS) and ultraviolet (UV) irradiation for understanding the process intensification benefits. The effect of operating parameters as inlet pressure (HC) and power dissipation (UV based treatment) on the degree of polymerization has been studied initially...
October 6, 2018: Ultrasonics Sonochemistry
Juhi Singh, Pooja Mittal, Gunjan Vasant Bonde, Gufran Ajmal, Brahmeshwar Mishra
Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. But the therapeutic application of Qu is hampered by its low oral bioavailability and its unfavourable physicochemical characteristics. The present work aimed at formulation of Quercetin loaded Soluplus® micelles (SMs) so as to enhance its bioavailability and provide prolonged release for the management of diabetes...
October 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Dongsheng Liu, Ang Hu, Kefeng Zhang
Software-defined radio (SDR) is a good solution for complying with the existing and incoming protocols for emerging wireless sensor networks (WSN) and internet of things (IoT) applications. The frequency synthesizer in a SDR tranceiver usually consists of a phase locked loop (PLL) and a post synthesizer. The PLL is the narrow band signal source and the post synthesizer generates wideband outputs by mixing and dividing. Compared with a frequency synthesizer utilizing the wideband PLL, this synthesizer features relatively constant loop parameters and mitigates the requirement for the oscillator...
October 14, 2018: Sensors
Li Key Yeo, Temidayo O B Olusanya, Cheng Shu Chaw, Amal Ali Elkordy
Novel niosomal formulations containing cinnarizine were developed to enhance its drug characteristics. In this work, niosomes (non-ionic surfactant vesicles) were prepared by conventional thin-film hydration (TFH) and microfluidic (MF) methods with sorbitan monostearate (Span® 60), cholesterol, and co-surfactants (Cremophor® ELP, Cremophor® RH40 and Solutol® HS15) as key excipients. The aim was to study the effect of cinnarizine on the characteristics of different niosomal formulations manufactured by using different methods...
October 13, 2018: Pharmaceutics
Xiqun Lu, Hanzhang Xu, Bin Zhao
The contact between a rigid flat and a coated asperity is studied using the finite element method. The substrate is assumed as the power-law hardening elastic⁻plastic material. The effect of the hardening exponent of the substrate ( n ) on the contact behaviors including contact load, area, coating thickness variation and stress in the coating, is investigated. It shows larger hardening exponent results in larger contact loads and larger maximum stresses in the coating at a given interference, and leads to smaller contact area at a specific contact load...
October 12, 2018: Materials
Dina S Shokry, Laura J Waters, Gareth M B Parkes, John C Mitchell, Martin J Snowden
The unique character of bile salts to self-assemble into hydrogels in the presence of halide salts was exploited in this work to facilitate the prediction of human intestinal absorption (%HIA) for a set of 25 compounds. This was achieved by firstly incorporating each compound separately within the process of gel formation to create a series of gel-drug membranes. Scanning Electron Microscopy (SEM) analysis of the freeze-dried samples of the blank bile salt hydrogels and drug loaded bile salt hydrogels indicated a unique microstructure made of a network of intertwined fibrils...
October 12, 2018: Journal of Pharmaceutical Sciences
Natacha Akshoomoff, Timothy T Brown, Roger Bakeman, Donald J Hagler
OBJECTIVE: The NIH Toolbox Cognition Battery (NTCB) is a brief computerized method for evaluating neuropsychological functions in children, adolescents, and adults. We examined how performance on the 2 executive function measures of cognitive flexibility and inhibitory control was related to performance on the other NTCB measures across development. METHOD: Participants were 1,020 typically developing individuals between the ages of 3 and 21 from the Pediatric Imaging, Neurocognition, and Genetics Study who were divided into 5 age groups (3-6, 7-9, 10-13, 14-17, and 18-21)...
October 2018: Neuropsychology
Pavimol Angsantikul, Soracha Thamphiwatana, Qiangzhe Zhang, Kevin Spiekermann, Jia Zhuang, Ronnie H Fang, Weiwei Gao, Marygorret Obonyo, Liangfang Zhang
Inspired by the natural pathogen-host interactions and adhesion, this study reports on the development of a novel targeted nanotherapeutics for the treatment of Helicobacter pylori ( H. pylori ) infection. Specifically, plasma membranes of gastric epithelial cells (e.g. AGS cells) are collected and coated onto antibiotic-loaded polymeric cores, the resulting biomimetic nanoparticles (denoted AGS-NPs) bear the same surface antigens as the source AGS cells and thus have inherent adhesion to H. pylori bacteria...
June 2018: Advanced therapeutics
Marcus Kiiti Borges, Thais Nakayama Lopes, Marina Maria Biella, Alaíse Siqueira, Sivan Mauer, Ivan Aprahamian
Background: Alzheimer's disease (AD) is traditionally subdivided into early onset (EOAD) and late onset (LOAD). EOAD has an onset before age 65 years and accounts for 1-5% of all cases. Two main presentation types of AD are familial and sporadic. Case presentation: The authors present the case of a 68-year-old retired white man, with a college level educational background. At 55 years of age, the patient presented cognitive decline with short-term memory impairment and slowed, hesitant speech. At 57 years, he was unable to remember the way to work, exhibiting spatial disorientation...
2018: Frontiers in Psychiatry
Kaori L Ito, Amit Kumar, Artemis Zavaliangos-Petropulu, Steven C Cramer, Sook-Lei Liew
Lesion analyses are critical for drawing insights about stroke injury and recovery, and their importance is underscored by growing efforts to collect and combine stroke neuroimaging data across research sites. However, while there are numerous processing pipelines for neuroimaging data in general, few can be smoothly applied to stroke data due to complications analyzing the lesioned region. As researchers often use their own tools or manual methods for stroke MRI analysis, this could lead to greater errors and difficulty replicating findings over time and across sites...
2018: Frontiers in Neuroinformatics
Man Ying, Jia Zhuang, Xiaoli Wei, Xinxin Zhang, Yue Zhang, Yao Jiang, Diana Dehaini, Mengchun Chen, Silun Gu, Weiwei Gao, Weiyue Lu, Ronnie H Fang, Liangfang Zhang
The recent emergence of biomimetic nanotechnology has facilitated the development of next-generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, we report on the remote loading of small molecule therapeutics into cholesterol-enriched platelet membrane-derived vesicles for disease-targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved...
May 30, 2018: Advanced Functional Materials
Neethu George, Pretesh Rohan Kiran, T Sulekha, Joseph S Rao, Prem Kiran
Context: Buses take up more than 90% of public transport in Indian cities and serve as a cheap and convenient mode of transport for all classes of society. However, the well-being of employees of this mode of transport is paramount in passenger and personal safety. As in any job, the person has to balance work and personal issues. Work-life balance is a concept that supports the effort from an employee in any sector to split their time and energy to balance work and personal lives. Materials and Methods: A cross-sectional study using a structured interview schedule was conducted among 103 Karnataka State Road Transport Corporation (KSRTC) workers in Anekal town, Karnataka, to determine the work-life balance among them...
May 2018: Indian Journal of Occupational and Environmental Medicine
Mikel Abasolo, Josu Aguirrebeitia, Javier Vallejo, Joseba Albizuri, Ibai Coria
Misfit is unavoidable in dental implant-supported prostheses due to machining process or inappropriate assembling, and the definition of an admissible misfit is still a controversial issue. This work aims to understand the behavior of the screws in dental implant-supported prostheses to estimate an admissible vertical misfit value in terms of screw fatigue failure. For that purpose, a finite element model of a dental implant-supported prosthesis was created and analyzed. Vertical misfits were introduced in different positions, the lower and upper screws were tightened to the bolting force values recommended by the manufacturer, and two different occlusal loads were analyzed...
October 15, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Shaun Porter, Noah D Silverberg, Naznin Virji-Babul
OBJECTIVES: To examine the neurophysiological correlates and brain network organization underlying physical and cognitive exertion in active young adults. DESIGN: Repeated measures. METHODS: Thirteen healthy adults completed three exertion tasks in a counterbalanced order: a graded working memory task (anti-saccade and serial addition task (ASAT)), a graded exercise task (cycling on a stationary bicycle) (EX) and a combined graded working memory and exercise task (ASAT+EX)...
October 3, 2018: Journal of Science and Medicine in Sport
Mohsin Qureshi, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Yasmin Sultana
The present work was designed to explore the efficacy of neuroactive drug (risperidone) loaded chitosan lipid nano particle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia via nasal route. The three-factor and three-level formulation by design approach was used for optimization and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation study, in-vivo behavior study, and stability study...
October 11, 2018: Current Drug Delivery
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"