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https://www.readbyqxmd.com/read/28723467/human-papillomavirus-infection-and-vaccination-in-males
#1
REVIEW
Eugenio Ventimiglia, Simon Horenblas, Asif Muneer, Andrea Salonia
CONTEXT: Human papillomavirus (HPV) is the commonest sexually transmitted pathogen in humans and is linked to the aetiopathogenesis for both benign and malignant disease in men. OBJECTIVE: To evaluate and summarise the evidence for HPV infection and vaccination in men. EVIDENCE ACQUISITION: A search of Medline, PubMed, and Scopus was performed to identify articles published in English within the last 10 yr addressing HPV epidemiology, the natural history of HPV infection and its long-term consequences, and vaccination in men...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720108/early-pregnancy-sex-steroids-during-primiparous-pregnancies-and-maternal-breast-cancer-a-nested-case-control-study-in-the-northern-sweden-maternity-cohort
#2
Renée T Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist, Eva Lundin
BACKGROUND: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. METHODS: We conducted a nested case-control study in the Northern Sweden Maternity Cohort (1975-2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection)...
July 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28719596/the-influence-of-fcgr2a-and-fcgr3a-polymorphisms-on-the-survival-of-patients-with-recurrent-or-metastatic-squamous-cell-head-and-neck-cancer-treated-with-cetuximab
#3
T Magnes, T Melchardt, C Hufnagl, L Weiss, C Mittermair, D Neureiter, E Klieser, G Rinnerthaler, S Roesch, A Gaggl, R Greil, A Egle
FCGR2A-H131R and FCGR3A-V157F are single-nucleotide polymorphisms known to influence the outcome of patients treated with rituximab, cetuximab and trastuzumab. We investigated the impact of these polymorphisms on the clinical outcome of 103 patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with a platinum compound, fluorouracil and cetuximab as palliative first-line therapy. The survival of patients with FCGR2A-131H/H and/or FCGR3A-157V/V genotypes was significantly longer compared with patients carrying 131R and 157F alleles (median progression-free survival (PFS): 5...
July 18, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28714298/effect-of-sugammadex-on-coagulation-as-detected-by-rotational-thromboelastometry-in-morbidly-obese-patients
#4
Michele Carron, Diana Bertini, Tancredi Prandini, Francesca Fanton, Mirto Foletto, Carlo Ori, Egle Perissinotto, Paolo Simioni
BACKGROUND: Sugammadex, which is used to reverse rocuronium-induced neuromuscular blockade, has a limited and transient effect on activated partial thromboplastin time and prothrombin time. However, no data are available on the effects of sugammadex on coagulation in morbidly obese patients, as assessed by rotational thromboelastometry (ROTEM®). METHODS: Sixty patients received sugammadex 2 mg/kg or 4 mg/kg to reverse moderate or deep rocuronium-induced neuromuscular blockade (n = 30/group) at the end of surgery under desflurane anesthesia...
July 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28700908/endothelial-glycocalyx-mediated-nitric-oxide-production-in-response-to-selective-afm-pulling
#5
Anne Marie W Bartosch, Rick Mathews, John M Tarbell
Nitric oxide (NO) is a regulatory molecule in the vascular system and its inhibition due to endothelial injury contributes to cardiovascular disease. The glycocalyx is a thin layer of glycolipids, glycoproteins, and proteoglycans on the surface of mammalian epithelial cells. Extracellular forces are transmitted through the glycocalyx to initiate intracellular signaling pathways. In endothelial cells (ECs), previous studies have shown the glycocalyx to be a significant mediator of NO production; degradation of the endothelial glycocalyx layer (EGL) drastically reduces EC production of NO in response to fluid shear stress...
July 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28693326/multiscale-morphology-of-nanoporous-copper-made-from-intermetallic-phases
#6
Tobias Egle, Cédric Barroo, Nare Janvelyan, Andreas C Baumgaertel, Austin J Akey, Monika M Biener, Cynthia M Friend, David C Bell, Juergen Biener
Many application-relevant properties of nanoporous metals critically depend on their multiscale architecture. For example, the intrinsically high step-edge density of curved surfaces at the nanoscale provides highly reactive sites for catalysis, whereas the macroscale pore and grain morphology determines the macroscopic properties, such as mass transport, electrical conductivity, or mechanical properties. In this work, we systematically study the effects of alloy composition and dealloying conditions on the multiscale morphology of nanoporous copper (np-Cu) made from various commercial Zn-Cu precursor alloys...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28686697/prognostic-score-in-patients-with-recurrent-or-metastatic-carcinoma-of-the-head-and-neck-treated-with-cetuximab-and-chemotherapy
#7
Teresa Magnes, Thomas Melchardt, Lukas Weiss, Christof Mittermair, Daniel Neureiter, Eckhard Klieser, Simon Gampenrieder, Gerhard Moser, Alexander Gaggl, Richard Greil, Alexander Egle
Despite modern treatment approaches, survival of patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) remains low and it is difficult to identify patients who derive optimal benefit from treatment. We therefore analyzed which commonly available laboratory and clinical parameters may help improve the prognostication in this patient group. This retrospective monocenter analysis includes 128 patients with recurrent or metastatic SCCHN treated with cetuximab alone or in combination with polychemotherapy as first line therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28683218/biokinetics-of-aerosolized-liposomal-ciclosporin-a-in-human-lung-cells-in-vitro-using-an-air-liquid-cell-interface-exposure-system
#8
Otmar Schmid, Corinne Jud, Yuki Umehara, Dominik Mueller, Albert Bucholski, Friedrich Gruber, Oliver Denk, Roman Egle, Alke Petri-Fink, Barbara Rothen-Rutishauser
BACKGROUND: Inhalation of aerosolized drugs is a promising route for noninvasive targeted drug delivery to the lung. Nanocarrier systems such as liposomes have been explored for inhalation therapy opening new avenues, including stabilization of nonsoluble drugs (e.g., Ciclosporin A [CsA]) and controlled release. METHODS: The biokinetic behavior of the immunosuppressive drug CsA encapsulated in liposomes (L-CsA) at the lung epithelial barrier was studied in vitro...
July 6, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28681271/cell-cycle-analysis-in-the-rat-external-granular-layer-evaluated-by-several-bromodeoxyuridine-immunoperoxidase-staining-protocols
#9
Vanesa Molina, Lucía Rodríguez-Vázquez, David Owen, Oliver Valero, Joaquín Martí
An important step in bromodeoxyuridine (BrdU) immunohistochemistry is the production of single-stranded DNA to make the incorporated BrdU accessible to the antibodies. This paper examines the effect of distinct DNA denaturation pretreatments (DNase I, sodium citrate buffer, endonuclease Eco RI and exonuclease III, and HCl hydrolysis) on detection of BrdU. We found that all the methods used in the partial denaturation of DNA combined good nuclear immunostaining with acceptable tissue integrity. We also observed that these immunohistochemical protocols revealed a spatial pattern in the distribution of DNA-synthesizing cells within the cerebellar external granular layer (EGL) of 10-day-old rats, allowing us to estimate the fraction of S-phase cells...
July 6, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28679628/recruitment-of-epac2a-to-insulin-granule-docking-sites-regulates-priming-for-exocytosis
#10
Ida Alenkvist, Nikhil R Gandasi, Sebastian Barg, Anders Tengholm
Epac is a cAMP-activated guanine nucleotide exchange factor that mediates cAMP signaling in various types of cells, including β-cells, where it is involved in the control of insulin secretion. Upon activation, the protein redistributes to the plasma membrane but the underlying molecular mechanisms and functional consequences are unclear. Using quantitative high-resolution microscopy we found that cAMP elevation caused rapid binding of Epac2A to the β-cell plasma membrane, where it accumulated specifically at secretory granules and rendered them more prone to undergo exocytosis...
July 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28673730/syphilitic-coronary-artery-ostial-stenosis-resulting-in-acute-myocardial-infarction
#11
Rūta Žvirblytė, Eglė Ereminienė, Aistė Montvilaitė, Antanas Jankauskas, Vytenis Ivanauskas
Cardiovascular abnormalities are well-known manifestations of a late form of syphilis - tertiary syphilis. Since the era of antibiotics, the incidence of late manifestations of syphilis has declined almost to a rare entity. The injury of aorta (the aortitis with a dilatation of aortic root and its associated complications) is the most common between all the cardiovascular lesions. A less common manifestation of syphilitic aortitis is coronary artery ostial narrowing related to aortic wall thickening. We present the case of a 37-year-old male who was treated for an acute myocardial infarction due to bilateral coronary artery ostial stenosis secondary to syphilitic aortitis...
June 20, 2017: Medicina
https://www.readbyqxmd.com/read/28669594/potential-to-induce-dentinal-cracks-during-retreatment-procedures-of-teeth-treated-with-russian-red-an-ex-vivo-study
#12
Eglė Nedzinskienė, Vytautė Pečiulienė, Jolanta Aleksejūnienė, Rasmutė Manelienė, Saulius Drukteinis, Audronė Jakaitienė
OBJECTIVE: The aim of this study was to compare the impact of treatment procedures on roots previously treated with resorcinol-formaldehyde resin and analyze the effectiveness of dye and magnification for the detection of dentin cracks. MATERIALS AND METHODS: Distal roots of 80 permanent first mandibular molars with a single canal were sectioned at 3mm and 9mm from the anatomical apex. Two groups were formed according to the method used for root canal penetration: group 1 (K-file and Pro Taper instruments) and group 2 (Ultrasound with Pro Ultra and Pro Taper files)...
June 7, 2017: Medicina
https://www.readbyqxmd.com/read/28668306/periodontal-status-in-18-year-old-lithuanian-adolescents-an-epidemiological-study
#13
Eglė Bendoraitienė, Jūratė Zūbienė, Ingrida Vasiliauskienė, Kristina Saldūnaitė, Vilija Andruškevičienė, Nomeda Basevičienė, Eglė Slabšinskienė
OBJECTIVE: The aim of this study was to investigate the periodontal and oral hygiene status of 18-year-old Lithuanian adolescents. MATERIALS AND METHODS: Cross-sectional data were collected by a multistage sampling approach that was used to draw a representative sample of 1063 adolescents attending schools. In total, 20 schools from the alphabetical list of educational institutions in Lithuania agreed to participate. Periodontal status was evaluated using the Periodontal Screening and Recording (PSR) index...
June 23, 2017: Medicina
https://www.readbyqxmd.com/read/28657462/the-reception-of-gall-s-organology-in-early-nineteenth-century-vilnius
#14
Eglė Sakalauskaitė-Juodeikienė, Paul Eling, Stanley Finger
Much has been written about the development and reception of Franz Joseph Gall's (1758-1828) ideas in Western Europe. There has been little coverage, however, of how his Schädellehre or organology was received in Eastern Europe. With this in mind, we examined the transmission and acceptance/rejection of Gall's doctrine in Vilnius (now Lithuania). We shall focus on what two prominent professors at Vilnius University felt about organology. The first of these men was Andrew Sniadecki (1768-1838), who published an article on Gall's system in the journal Dziennik Wileński in 1805...
June 28, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28655761/the-resolution-of-acute-inflammation-induced-by-cyclic-amp-is-dependent-on-annexin-a1
#15
Kátia M Lima, Juliana P Vago, Thaís R Caux, Graziele Letícia Negreiros-Lima, Michelle A Sugimoto, Luciana P Tavares, Raquel G Arribada, Aline Alves F Carmo, Izabela Galvão, Bruno Rocha C Costa, Frederico M Soriani, Vanessa Pinho, Egle Solito, Mauro Perretti, Mauro M Teixeira, Lirlândia P Sousa
Annexin A1 (AnxA1) is a glucocorticoidregulated protein known for its antiinflammatory and proresolving effects. We have previously shown that cAMP enhancing compounds rolipram (ROL - a PDE4 inhibitor) and db-cAMP (cAMP mimetic) drive caspasedependent resolution of neutrophilic inflammation. In this follow up study, we investigated whether AnxA1 could be involved in the proresolving properties of these compounds using a model of LPS-induced inflammation in BALB/c mice. The treatment with ROL or db-cAMP at the peak of inflammation shortened resolution intervals, improved resolution indices and increased AnxA1 expression...
June 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28639712/the-effect-of-childcare-activities-on-cognitive-status-and-depression-in-older-adults-gender-differences-in-a-4-4-year-longitudinal-study
#16
Caterina Trevisan, Maria Valentina Pamio, Chiara Curreri, Stefania Maggi, Giovannella Baggio, Sabina Zambon, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: Although involvement in childcare activities seems to promote better physical and mental health in older adults, its impact on cognitive status and depression has not yet been fully elucidated. We aimed to analyze the association between engagement in childcare activities and cognitive and psychological status over a 4.4-year period in community-dwelling older adults. METHODS: Two thousand one hundred four subjects older than 65 years without severe cognitive impairment at baseline were categorized according to the frequency of their involvement in childcare activities (everyday, occasionally, never)...
June 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28633908/dynamics-of-the-cell-division-orientation-of-granule-cell-precursors-during-cerebellar-development
#17
Satoshi Miyashita, Toma Adachi, Mariko Yamashita, Takayuki Sota, Mikio Hoshino
The cerebellar granule cell (GC) system provides a good model for studying neuronal development. In the external granule layer (EGL), granule cell precursors (GCPs) rapidly and continuously divide to produce numerous GCs as well as GCPs. In some brain regions, the orientation of cell division affects daughter cell fate, thus the direction of GCP division is related to whether it produces a GCP or a GC. Therefore, we tried to characterize the orientation of GCP division from embryonic to postnatal stages and to identify an environmental cue that regulates the orientation...
June 17, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28629908/use-of-underarm-cosmetic-products-in-relation-to-risk-of-breast-cancer-a-case-control-study
#18
Caroline Linhart, Heribert Talasz, Evi M Morandi, Christopher Exley, Herbert H Lindner, Susanne Taucher, Daniel Egle, Michael Hubalek, Nicole Concin, Hanno Ulmer
BACKGROUND: Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP application. METHODS: Self-reported history of UCP use was compared between 209 female BC patients (cases) and 209 healthy controls. Aluminum concentration in breast tissue was measured in 100 cases and 52 controls. Multivariable conditional logistic regression analysis was performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for established BC risk factors...
June 6, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28626619/african-penguins-follow-the-gaze-direction-of-conspecifics
#19
Christian Nawroth, Egle Trincas, Livio Favaro
Gaze following is widespread among animals. However, the corresponding ultimate functions may vary substantially. Thus, it is important to study previously understudied (or less studied) species to develop a better understanding of the ecological contexts that foster certain cognitive traits. Penguins (Family Spheniscidae), despite their wide interspecies ecological variation, have previously not been considered for cross-species comparisons. Penguin behaviour and communication have been investigated over the last decades, but less is known on how groups are structured, social hierarchies are established, and coordination for hunting and predator avoidance may occur...
2017: PeerJ
https://www.readbyqxmd.com/read/28622389/-foraging-for-a-place-to-lay-eggs-a-genetic-link-between-foraging-behaviour-and-oviposition-preferences
#20
Murray W McConnell, Mark J Fitzpatrick
Gravid female arthropods in search of egg-laying substrates embark on foraging-like forays: they survey the environment assessing multiple patches, tasting each with their tarsi and proboscis, and then, if interested, they deposit an egg (or eggs). In fruit flies, Drosophila melanogaster, allelic variation in the foraging gene (for) underlies the rover/sitter foraging behaviour polymorphism. Rover flies (forR) are more active foragers (both within and between food patches) compared to sitters (fors). In nematodes, Caenorhabditis elegans, a mutation in egl-4, the ortholog of for, leads to aberrations in egg laying...
2017: PloS One
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