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Katharina T Prochazka, Thomas Melchardt, Florian Posch, Konstantin Schlick, Alexander Deutsch, Christine Beham-Schmid, Lukas Weiss, Thomas Gary, Daniel Neureiter, Eckhard Klieser, Richard Greil, Peter Neumeister, Alexander Egle, Martin Pichler
BACKGROUND: Blood-based parameters are gaining increasing interest as potential prognostic biomarkers in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this study was to comprehensively evaluate the prognostic significance of pretreatment plasma uric acid levels in patients with newly diagnosed DLBCL. METHODS: The clinical course of 539 DLBCL patients, diagnosed and treated between 2004 and 2013 at two Austrian high-volume centres with rituximab-based immunochemotherapy was evaluated retrospectively...
October 20, 2016: British Journal of Cancer
Marilena Vecchi, Carmen Barba, Debora De Carlo, Micol Stivala, Renzo Guerrini, Emilio Albamonte, Domiziana Ranalli, Domenica Battaglia, Giada Lunardi, Clementina Boniver, Benedetta Piccolo, Francesco Pisani, Gaetano Cantalupo, Giuliana Nieddu, Susanna Casellato, Silvia Cappanera, Elisabetta Cesaroni, Nelia Zamponi, Domenico Serino, Lucia Fusco, Alessandro Iodice, Filippo Palestra, Lucio Giordano, Elena Freri, Ilaria De Giorgi, Francesca Ragona, Tiziana Granata, Isabella Fiocchi, Stefania Maria Bova, Massimo Mastrangelo, Alberto Verrotti, Sara Matricardi, Elena Fontana, Davide Caputo, Francesca Darra, Bernardo Dalla Bernardina, Francesca Beccaria, Giuseppe Capovilla, Maria Pia Baglietto, Alessandra Gagliardi, Aglaia Vignoli, Maria Paola Canevini, Egle Perissinotto, Stefano Francione
OBJECTIVE: To describe the clinical, neuropsychological, and psychopathologic features of a cohort of children with a new diagnosis of symptomatic or presumed symptomatic focal epilepsy at time of recruitment and through the first month. The selected population will be followed for 2-5 years after enrollment to investigate the epilepsy course and identify early predictors of drug resistance. METHODS: In this observational, multicenter, nationwide study, children (age 1 month-12...
October 20, 2016: Epilepsia
Petras Prakas, Eglė Rudaitytė, Dalius Butkauskas, Liuda Kutkienė
In the present study, we describe Sarcocystis entzerothi n. sp. from the European roe deer (Capreolus capreolus) based on the microscopical and DNA analysis. By light microscopy (LM), cysts of S. entzerothi were spindle-shaped with pointed tips, 950-1900 × 70-150 μm in size and had 5-6 μm long finger-like cyst wall protrusions. Cyst wall of S. entzerothi by transmission electron microscopy (TEM) was type 10a-like; villar protrusions were up to 1.2 μm wide, densely packed, lying about 0.1 μm between each other, had profuse microgranules and microfilaments, parasitophorous vacuolar membrane had many minute invaginations, and the ground substance layer measured up to 0...
October 18, 2016: Parasitology Research
John E Stone, Peter Messmer, Robert Sisneros, Klaus Schulten
Large scale molecular dynamics simulations produce terabytes of data that is impractical to transfer to remote facilities. It is therefore necessary to perform visualization tasks in-situ as the data are generated, or by running interactive remote visualization sessions and batch analyses co-located with direct access to high performance storage systems. A significant challenge for deploying visualization software within clouds, clusters, and supercomputers involves the operating system software required to initialize and manage graphics acceleration hardware...
May 2016: IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum: [proceedings]
Faten K Abd El-Hady, Walid Fayad, Carmine Iodice, Zeinab A El-Shahid, Mohamed S Abdel-Aziz, Egle Crudele, Giuseppina Tommonaro
Marine organisms have been considered as the richest sources of novel bioactive metabolites, which can be used for pharmaceutical purposes. In the last years, the interest for marine microorganisms has grown for their enormous biodiversity and for the evidence that many novel compounds isolated from marine invertebrates are really synthesized by their associated bacteria. Nevertheless, the discovery of a chemical communication Quorum sensing (QS) between bacterial cells and between bacteria and host has gained the researchers to expand the aim of their study toward the role of bacteria associated with marine invertebrates, such as marine sponge...
October 14, 2016: Current Microbiology
Egle Ramelyte, Sabrina A Schindler, Reinhard Dummer
Introduction The introduction of immunotherapies into clinical practice has substantially improved the prognosis of metastatic melanoma patients as well as patients suffering from other cancers. The two FDA-approved checkpoint inhibitors against PD-1 (nivolumab and pembrolizumab) have been shown to significantly improve patient survival while being less toxic than previous treatment options. Areas covered The current scientific literature on safety and adverse events (AEs) related to anti-PD-1 therapies has been investigated with special attention to case reports and to the latest results announced at the major clinical cancer and melanoma meetings, including ASCO (American Society of Clinical Oncology), ESMO (European Society of medical Oncology) and EADO (European Association of Dermato-Oncology) annual meetings...
October 13, 2016: Expert Opinion on Drug Safety
V Pibiri, A Ravarino, C Gerosa, M C Pintus, V Fanos, G Faa
The aim of this study was to analyze, by immunohistochemistry, the occurrence of stem/progenitor cells localized in the different niches of the developing human cerebellum. To this end, cerebellar samples were obtained from 3 fetuses and 3 newborns ranging, respectively, from 11 to 24 and from 30 to 38 weeks of gestation. Specimens were 10% formalin-fixed, routinely processed and paraffin-embedded; 3 μm-tick sections were immunostained with anti-SOX2 and PAX6 antibodies. Our study evidenced SOX2 and PAX6 immunoreactivity in precursors cells in all six developing human cerebella...
September 19, 2016: European Journal of Histochemistry: EJH
Nicola Veronese, Brendon Stubbs, Caterina Trevisan, Francesco Bolzetta, Marina De Rui, Stefania Maggi, Leonardo Sartori, Estella Musacchio, Sabina Zambon, Egle Perissinotto, Marianna Noale, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: Hyperuricemia (HU) is frequent in older people and associated with several medical conditions. The relationship between HU and physical performance is limited. We aimed to investigate the association between HU and physical performance over a 4.4 year follow-up in the elderly. METHODS: 1,904 community-dwelling older participants were followed for a mean of 4.4 years. HU at baseline was defined using serum uric acid (SUA) concentrations ≥ 6 and 7 mg/dl for women and men, respectively...
October 9, 2016: Arthritis Care & Research
A F N Volpini, T Thomazine, S H Umeo, G A Pereira, G A Linde, J S Valle, N B Colauto, F G Barcellos, S G H Souza
Enzymes produced by basidiomycetes that are involved in the cellulose degradation process, and their respective codifying genes, must be identified to facilitate the development of novel biotechnological strategies and applications in the agro-industry. The objective of this study was to identify prospective cellulase-producing genes and characterize their cellulolytic activity, in order to elucidate the potential biotechnological applications (with respect to vegetal residues) of basidiomycetes. The basidiomycete strains Lentinula edodes U8-1, Lentinus crinitus U9-1, and Schizophyllum commune U6-7 were analyzed in this study...
September 16, 2016: Genetics and Molecular Research: GMR
Egle Cekanaviciute, Marion S Buckwalter
Astrocytes regulate neuroinflammatory responses after stroke and in other neurological diseases. Although not all astrocytic responses reduce inflammation, their predominant function is to protect the brain by driving the system back to homeostasis after injury. They receive multidimensional signals within the central nervous system and between the brain and the systemic circulation. Processing this information allows astrocytes to regulate synapse formation and maintenance, cerebral blood flow, and blood-brain barrier integrity...
September 27, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Nicole Marquardt, Eliisa Kekäläinen, Puran Chen, Egle Kvedaraite, Jennifer N Wilson, Martin A Ivarsson, Jenny Mjösberg, Lena Berglin, Jesper Säfholm, Martijn L Manson, Mikael Adner, Mamdoh Al-Ameri, Per Bergman, Ann-Charlotte Orre, Mattias Svensson, Barbro Dahlén, Sven-Erik Dahlén, Hans-Gustaf Ljunggren, Jakob Michaëlsson
BACKGROUND: In contrast to the extensive knowledge about human NK cells in peripheral blood, relatively little is known about NK cells in human lung. Knowledge about the composition, differentiation, and function of human lung NK cells is critical to better understand their role in diseases affecting the lung, including asthma, COPD, infections, and cancer. OBJECTIVE: We sought to analyze and compare the phenotypic as well as functional characteristics of NK cells in the human lung and peripheral blood at the single cell level...
September 23, 2016: Journal of Allergy and Clinical Immunology
Anne Oberguggenberger, Monika Sztankay, Raphael Johannes Morscher, Barbara Sperner-Unterweger, Ingrid Weber, Michael Hubalek, Georg Kemmler, Johannes Zschocke, Caroline Martini, Daniel Egle, Martina Dünser, Eva Gamper, Verena Meraner
OBJECTIVE: We investigated the psychosocial consequences of genetic counseling and testing (GCT) for hereditary breast and ovarian cancer (HBOC) at follow-up in a "real-life" sample of counselees at an Austrian tertiary care center. METHODS: The study cohort included counselees who had undergone genetic counseling for HBOC and completed a follow-up self-report questionnaire battery on psychosocial outcomes (quality of life, psychological distress, satisfaction with counseling and decisions)...
October 2016: Journal of Psychosomatic Research
Chunmei Zhang, Ninghui Zhao, Yao Chen, Donghua Zhang, Jinyuan Yan, Wei Zou, Keqin Zhang, Xiaowei Huang
The nematode Caenorhabditis elegans exhibits behavioral responses to a wide range of odorants associated with food and pathogens. A previous study described a Trojan Horse like strategy of pathogenesis whereby the bacterium Bacillus subtilis emits the volatile organic compound 2-heptanone to trap C. elegans for successful infection. Here, we further explored the receptor for 2-heptanone as well as the pathway involved in signal transduction in C. elegans. Our experiments showed that 2-heptanone sensing depended on the function of AWC neurons and a GPCR encoded by str-2...
September 22, 2016: Journal of Biological Chemistry
Egle Mickeviciute, Egle Ivanauskiene, Viktorija Noreikiene
OBJECTIVE: The aim of this study was to evaluate the effects of staining solutions on the color stability and roughness of different provisional resin material. MATERIAL AND METHODS: Three different materials were tested (two polymethylmethacrylate and one bis-acryl composite resins) in cola and coffee and for 1 and 4 weeks. 240 specimens were used - half of them polished and other half not. Color measurements were made before and after immersions using CIE L*a*b*...
2016: Stomatologija
Egle Lapenaite, Kristina Lopatiene, Aira Ragauskaite
OBJECTIVE: The aim of the study is to evaluate the effectiveness of fluoride and casein topical preparations in the prevention of white spot lesions during and after fixed orthodontic treatment. MATERIAL AND METHODS: Information search for controlled studies on humans published in the English language between 2008 and 2013 was conducted in Medline via PubMed, ScienceDirect, and Oxford University Press: Oxford journals and The Cochrane Library, as well as the Web search Google Scholar...
2016: Stomatologija
Alexander Arthur, Phillip J McCall, Lisa Jolly, John Kinsella, Alan Kirk, Ben G Shelley
AIM: We investigated if the serum biomarkers of endothelial glycocalyx layer (EGL) disruption, heparan sulfate proteoglycan (HSPG) and syndecan-1 (SDC1) were elevated following lung resection surgery. METHODS: Plasma samples were collected from 16 patients undergoing lobectomy for primary lung cancer. HSPG and SDC1 were measured at five perioperative timepoints. Postoperative oxygenation was recorded. RESULTS: Post-hoc pair wise comparisons showed SDC1 concentration was significantly elevated on postoperative day 2, p < 0...
October 2016: Biomarkers in Medicine
Vitalij Novickij, Audrius Grainys, Eglė Lastauskienė, Rūta Kananavičiūtė, Dovilė Pamedytytė, Lilija Kalėdienė, Jurij Novickij, Damijan Miklavčič
Electroporation is a phenomenon occurring due to exposure of cells to Pulsed Electric Fields (PEF) which leads to increase of membrane permeability. Electroporation is used in medicine, biotechnology, and food processing. Recently, as an alternative to electroporation by PEF, Pulsed ElectroMagnetic Fields (PEMF) application causing similar biological effects was suggested. Since induced electric field in PEMF however is 2-3 magnitudes lower than in PEF electroporation, the membrane permeabilization mechanism remains hypothetical...
2016: Scientific Reports
Egle Juskeviciute, Rachael P Dippold, Anil N Antony, Aditi Swarup, Rajanikanth Vadigepalli, Jan B Hoek
Liver regeneration is a clinically significant tissue repair process, which is suppressed by chronic alcohol intake through poorly understood mechanisms. Recently, miR-21 has been suggested to serve as a crucial microRNA regulator driving hepatocyte proliferation after partial hepatectomy (PHx) in mice. However, we reported recently that miR-21 is significantly upregulated in ethanol-fed rats at 24h after PHx despite inhibition of cell proliferation, suggesting a more complex role for this microRNA. Here, we investigate how inhibition of miR-21 in vivo affects the early phase of liver regeneration in ethanol-fed rats...
September 15, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Adriana Malena, Boris Pantic, Doriana Borgia, Gianluca Sgarbi, Giancarlo Solaini, Ian J Holt, Antonella Spinazzola, Egle Perissinotto, Marco Sandri, Alessandra Baracca, Lodovica Vergani
Pathological mutations in the mitochondrial DNA (mtDNA) produce a diverse range of tissue-specific diseases and the proportion of mutant mitochondrial DNA can increase or decrease with time via segregation, dependent on the cell or tissue type. Previously we found that adenocarcinoma (A549.B2) cells favored wild-type (WT) mtDNA, whereas rhabdomyosarcoma (RD.Myo) cells favored mutant (m3243G) mtDNA. Mitochondrial quality control (mtQC) can purge the cells of dysfunctional mitochondria via mitochondrial dynamics and mitophagy and appears to offer the perfect solution to the human diseases caused by mutant mtDNA...
September 14, 2016: Autophagy
Ana Tichonova, Inesa Rimdeikienė, Daiva Petruševičienė, Eglė Lendraitienė
BACKGROUND AND OBJECTIVE: Psychological responses to the initial injury and rehabilitation might be an important additional determinant of functional level outcomes after knee surgery. The objectives of this study were (1) to measure pain catastrophizing and kinesiophobia levels and (2) determine their association with self-reported subjective knee function during rehabilitation, following anterior cruciate ligament reconstruction (ACLR) and meniscectomy. MATERIALS AND METHODS: The study involved 41 participants...
2016: Medicina
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