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https://www.readbyqxmd.com/read/29781068/pelvic-floor-muscle-training-with-or-without-tibial-nerve-stimulation-and-lifestyle-changes-have-comparable-effects-on-the-overactive-bladder-a-randomized-clinical-trial
#1
Lina Bykoviene, Raimondas Kubilius, Rosita Aniuliene, Egle Bartuseviciene, Arnoldas Bartusevicius
PURPOSE: To compare effects of transcutaneous posterior tibial nerve stimulation (TPTNS) and pelvic floor muscle training (PFMT) in women with overactive bladder syndrome (OAB). MATERIAL AND METHODS: We randomized 67 women ? 18 years with OAB to three parallel groups: group I (n = 22) received life-style recommendations (LSR) only; group II (n = 24) had LSR + PFMT and group III (n = 21) had LSR + PFMT + TPTNS. Urgency, evaluated by a 3-day voiding diary before treatment and six weeks later, was the main outcome measure...
May 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29778961/uva-induced-antimicrobial-activity-of-zno-ag-nanocomposite-covered-surfaces
#2
Meeri Visnapuu, Merilin Rosenberg, Egle Truska, Ergo Nõmmiste, Andris Šutka, Anne Kahru, Mihkel Rähn, Heiki Vija, Kaja Orupõld, Vambola Kisand, Angela Ivask
Application of efficient antimicrobial surfaces has been estimated to decrease both, the healthcare-associated infections and the spread of antibiotic-resistant bacteria. In this paper, we prepared ZnO and ZnO/Ag nanoparticle covered surfaces and evaluated their antimicrobial efficacy towards a Gram-negative bacterial model (Escherichia coli), a Gram-positive bacterial model (Staphylococcus aureus) and a fungal model (Candida albicans) in the dark and under UVA illumination. The surfaces were prepared by spin coating aliquots of ZnO and ZnO/Ag nanoparticle suspensions onto glass substrates...
May 4, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29770421/quantitative-proteomics-and-systems-analysis-of-cultured-h9c2-cardiomyoblasts-during-differentiation-over-time-supports-a-function-follows-form-model-of-differentiation
#3
Cynthia Kankeu, Kylie Clarke, Delphi Van Haver, Kris Gevaert, Francis Impens, Anna Dittrich, H Llewelyn Roderick, Egle Passante, Heinrich J Huber
The rat cardiomyoblast cell line H9C2 has emerged as a valuable tool for studying cardiac development, mechanisms of disease and toxicology. We present here a rigorous proteomic analysis that monitored the changes in protein expression during differentiation of H9C2 cells into cardiomyocyte-like cells over time. Quantitative mass spectrometry followed by gene ontology (GO) enrichment analysis revealed that early changes in H9C2 differentiation are related to protein pathways of cardiac muscle morphogenesis and sphingolipid synthesis...
May 17, 2018: Molecular omics
https://www.readbyqxmd.com/read/29763885/intrauterine-growth-restriction-affects-cerebellar-granule-cells-in-the-developing-guinea-pig-brain
#4
Mary Tolcos, Annie McDougall, Amy Shields, Yoonyoung Chung, Rachael O'Dowd, Ann Turnley, Megan Wallace, Sandra Rees
Intrauterine growth restriction (IUGR) can lead to adverse neurodevelopmental sequelae in postnatal life. However, the effects of IUGR on the cerebellum are still to be fully elucidated. A major determinant of growth and development of the cerebellum is proliferation and subsequent migration of cerebellar granule cells. Our objective was to determine whether IUGR, induced by chronic placental insufficiency (CPI) in guinea pigs, results in abnormal cerebellar development due to deficits suggestive of impaired granule cell proliferation and/or migration...
May 15, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29721079/dna-methylation-signatures-predicting-bevacizumab-efficacy-in-metastatic-breast-cancer
#5
Simon Peter Gampenrieder, Gabriel Rinnerthaler, Hubert Hackl, Walter Pulverer, Andreas Weinhaeusel, Suzana Ilic, Clemens Hufnagl, Cornelia Hauser-Kronberger, Alexander Egle, Angela Risch, Richard Greil
Background: Biomarkers predicting response to bevacizumab in breast cancer are still missing. Since epigenetic modifications can contribute to an aberrant regulation of angiogenesis and treatment resistance, we investigated the influence of DNA methylation patterns on bevacizumab efficacy. Methods: Genome-wide methylation profiling using the Illumina Infinium HumanMethylation450 BeadChip was performed in archival FFPE specimens of 36 patients with HER2-negative metastatic breast cancer treated with chemotherapy in combination with bevacizumab as first-line therapy ( learning set )...
2018: Theranostics
https://www.readbyqxmd.com/read/29710397/is-portal-venous-pressure-modulation-still-indicated-for-all-recipients-in-living-donor-liver-transplantation
#6
Siyuan Yao, Toshimi Kaido, Ryuji Uozumi, Shintaro Yagi, Yosuke Miyachi, Ken Fukumitsu, Takayuki Anazawa, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
BACKGROUND: There is a consensus that portal venous pressure (PVP) modulation prevents portal hypertension (PHT) and consequent complications after adult living donor liver transplantation (ALDLT). However, PVP-modulation strategies need updating based on most recent findings. We examined our 10-year experience of PVP modulation and reevaluate whether it is necessary for all recipients or selected recipients in ALDLT. METHODS: In this retrospective study, 319 patients who underwent ALDLT from 2007 to 2016 were divided into three groups according to the necessity and results of PVP modulation: not indicated (n=189), indicated and successful (n=92), and indicated but failed (n=38)...
April 30, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29707296/sevoflurane-did-not-show-better-protective-effect-on-endothelial-glycocalyx-layer-compared-to-propofol-during-lung-resection-surgery-with-one-lung-ventilation
#7
Hye-Jin Kim, Eunsoo Kim, Seung-Hoon Baek, Hee Young Kim, Joo-Yun Kim, Juyeon Park, Eun-Ji Choi
Background: The endothelial glycocalyx layer (EGL) coats the alveolar capillary endothelium and plays important roles in pulmonary vascular protection, modulation, and hemostasis. Ischemia-reperfusion, which occurs during lung resection surgery with one lung ventilation (OLV), can damage the EGL. Sevoflurane is known for its protective effect against ischemia-reperfusion injury. Therefore, we hypothesized that lung resection surgery produces EGL damage and sevoflurane protects the EGL better than the intravenous anesthetic propofol...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29705512/internal-concentrations-of-perfluorobutane-sulfonate-pfbs-comparable-to-those-of-perfluorooctane-sulfonate-pfos-induce-reproductive-toxicity-in-caenorhabditis-elegans
#8
Fengjie Chen, Cuiyun Wei, Qiuyu Chen, Jie Zhang, Ling Wang, Zhen Zhou, Minjie Chen, Yong Liang
Perfluorobutane sulfonate (PFBS) is considered a less-toxic replacement for perfluorooctane sulfonate (PFOS), with multiple applications in industrial and consumer products. Previous studies comparing their toxicity generally used similar exposure levels, without taking internal concentrations into account. The current study compared the reproductive toxicity of PFOS and PFBS, at similar internal concentrations, to Caenorhabditis elegans (C. elegans). PFBS was much less bioaccumulative than PFOS. The 48-h median lethal concentrations (LC50 ) for PFOS and PFBS were 1...
April 26, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29702648/development-of-a-cardiac-loading-device-to-monitor-cardiac-function-during-ex-vivo-graft-perfusion
#9
Emilie Farine, Manuel U Egle, Alice C Boone, Sandro Christensen, Thierry P Carrel, Hendrik T Tevaearai Stahel, Sarah L Longnus
BACKGROUND: Ex vivo heart perfusion systems, allowing continuous perfusion of the coronary vasculature, have recently been introduced to limit ischemic time of donor hearts prior to transplantation. Hearts are, however, perfused in an unloaded manner (via the aorta) and therefore, cardiac contractile function cannot be reliably evaluated. OBJECTIVES: We aim to develop a ventricular loading device that enables monitoring of myocardial function in an ex vivo perfusion system...
2018: PloS One
https://www.readbyqxmd.com/read/29701886/dbs-electrodes-with-single-disconnected-contacts-long-term-observation-and-implications-for-the-management
#10
Niels Allert, Egle Jusciute, Regina Quindt, Alexandra Lindlau, Brit Meike Nolden, Mohammadreza Daryaeitabar, Hans Karbe
OBJECTIVES: To evaluate the long-term course of quadripolar DBS electrodes with disconnected single contacts that cannot be used for DBS. MATERIALS AND METHODS: Quadripolar electrodes with open circuits of single contacts or monopolar impedances >6500 Ω were identified from a cohort of 2082 electrodes from 1044 patients with variable movement disorders. The long-term course was analyzed from follow-up data. RESULTS: Disconnected contacts were found in 58 electrodes (2...
April 27, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29700640/molecular-identification-of-sarcocystis-lutrae-apicomplexa-sarcocystidae-in-muscles-of-five-species-of-the-family-mustelidae
#11
Petras Prakas, Živilė Strazdaitė-Žielienė, Eglė Rudaitytė-Lukošienė, Elena Servienė, Dalius Butkauskas
Carnivores usually act as definitive hosts of Sarcocystis species. However, the number of reports on sarcocyst formation in musculature of predators is on the increase. In the present study, muscle samples of 68 mustelids collected in Lithuania were examined for sarcocysts of Sarcocystis species. Sarcocysts were detected in diaphragm, tongue and limb muscles of ten animals (14.7%) but were not discovered in the heart. Based on 18S rDNA, 28S rDNA, cox1 and ITS1 sequence analysis, Sarcocystis lutrae was identified in three American minks (Neovison vison), two beech martens (Martes foina), three Eurasian badgers (Meles meles), one Eurasian otter (Lutra lutra) and one European polecat (Mustela putorius)...
April 26, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29697719/changes-in-type-i-and-type-ii-collagen-expression-in-rat-mandibular-condylar-cartilage-associated-with-aging-and-dietary-loading
#12
Marko Orajärvi, Sakari Laaksonen, Riikka Hauru, Eerika Mursu, Egle Jonaviciute, Hanna-Marja Voipio, Aune Raustia, Pertti Pirttiniemi
AIMS: To evaluate the usefulness of diet board feeding as a model for temporomandibular joint (TMJ) research, characterize dietary loading-related morphometric changes in the mandibular condylar cartilage of aging rats, and investigate changes in type I and type II collagen expression in different age, sex, and diet groups. METHODS: Material was collected from a study that examined the effects of 1-year and 2-year diet board feeding on rats. In diet board feeding, rats must gnaw wood to reach their food, leading to a higher masticatory workload...
April 25, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29672201/effects-of-empathic-and-positive-communication-in-healthcare-consultations-a-systematic-review-and-meta-analysis
#13
Jeremy Howick, Andrew Moscrop, Alexander Mebius, Thomas R Fanshawe, George Lewith, Felicity L Bishop, Patriek Mistiaen, Nia W Roberts, Eglė Dieninytė, Xiao-Yang Hu, Paul Aveyard, Igho J Onakpoya
Background Practitioners who enhance how they express empathy and create positive expectations of benefit could improve patient outcomes. However, the evidence in this area has not been recently synthesised. Objective To estimate the effects of empathy and expectations interventions for any clinical condition. Design Systematic review and meta-analysis of randomised trials. Data sources Six databases from inception to August 2017. Study selection Randomised trials of empathy or expectations interventions in any clinical setting with patients aged 12 years or older...
January 1, 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29670697/imidazo-2-1-b-benzothiazol-derivatives-as-potential-allosteric-inhibitors-of-the-glucocorticoid-receptor
#14
Michael S Christodoulou, Federico Dapiaggi, Francesca Ghiringhelli, Stefano Pieraccini, Maurizio Sironi, Marianna Lucafò, Debora Curci, Giuliana Decorti, Gabriele Stocco, Chandra Sekhar Chirumamilla, Wim Vanden Berghe, Patrick Balaguer, Benoît Y Michel, Alain Burger, Egle M Beccalli, Daniele Passarella, Nadine Martinet
Glucocorticoid receptor (GCR) transactivation reporter gene assays were used as an initial high-throughput screening on a diversified library of 1200 compounds for their evaluation as GCR antagonists. A class of imidazo[2,1- b ]benzothiazole and imidazo[2,1- b ]benzoimidazole derivatives were identified for their ability to modulate GCR transactivation and anti-inflammatory transrepression effects utilizing GCR and NF-κB specific reporter gene assays. Modeling studies on the crystallographic structure of the GCR ligand binding domain provided three new analogues bearing the tetrahydroimidazo[2,1- b ]benzothiazole scaffold able to antagonize the GCR in the presence of dexamethasone (DEX) and also defined their putative binding into the GCR structure...
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29666474/the-cisd-gene-family-regulates-physiological-germline-apoptosis-through-ced-13-and-the-canonical-cell-death-pathway-in-caenorhabditis-elegans
#15
Skylar D King, Chipo F Gray, Luhua Song, Rachel Nechushtai, Tina L Gumienny, Ron Mittler, Pamela A Padilla
Programmed cell death, which occurs through a conserved core molecular pathway, is important for fundamental developmental and homeostatic processes. The human iron-sulfur binding protein NAF-1/CISD2 binds to Bcl-2 and its disruption in cells leads to an increase in apoptosis. Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3. In humans, mutations in CISD2 result in Wolfram syndrome 2, a disease in which the patients display juvenile diabetes, neuropsychiatric disorders and defective platelet aggregation...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29665495/towards-better-microbial-safety-of-fresh-produce-chlorophyllin-based-photosensitization-for-microbial-control-of-foodborne-pathogens-on-cherry-tomatoes
#16
Egle Paskeviciute, Bernadeta Zudyte, Zivile Luksiene
The aim of this study is to evaluate the antimicrobial efficiency of Chlorophyllin-based photosensitization for microbial control of cherry tomatoes. Chlorophyllin-based photosensitization (1.5 × 10-4  M, 3 J/cm2 ) significantly (2.4 log) reduced the population of naturally distributed surface attached various mesophilic bacteria (microbiota) on tomatoes. Moreover, the population of thermoresistant strains of food pathogens Bacillus cereus and Listeria monocytogenes inoculated on tomatoes was reduced by 1...
April 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29656243/different-permeabilization-patterns-of-splenocytes-and-thymocytes-to-combination-of-pulsed-electric-and-magnetic-field-treatments
#17
Vitalij Novickij, Auksė Zinkevičienė, Justinas Valiulis, Jurgita Švedienė, Algimantas Paškevičius, Eglė Lastauskienė, Svetlana Markovskaja, Jurij Novickij, Irutė Girkontaitė
Genetic manipulation of T cells is frequently inefficient, however, when combined with physical methods (i.e. electroporation) a promising alliance with immunotherapy can be formed. This study presents new data on permeabilization of murine thymocytes and splenocytes as a T cell model using pulsed electric (PEF) and electromagnetic field (EMF). The 300ns, 500ns, 2μs and 100μs pulse bursts in a broad range of PEF 0-8kV/cm were applied separately and in combination with 3.3T, 0.2kV/cm EMF pulses. The permeabilization efficiency was evaluated using fluorescent dye (YO-PRO-1) and flow cytometry...
April 10, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29649428/connections-of-annexin-a1-and-translocator-protein-18-kda-on-toll-like-receptor-stimulated-bv-2-cells
#18
Lorena Pantaleão, Gustavo Henrique Oliveira da Rocha, Chris Reutelingsperger, Manoela Tiago, Silvya Stucchi Maria-Engler, Egle Solito, Sandra P Farsky
BACKGROUND: Annexin A1 (ANXA1) and Translocator Protein-18KDa (TSPO) down-regulate neuroinflammation. We investigated the role of recombinant ANXA1 (rANXA) on TSPO functions on Toll Like Receptor (TLR) activated microglia. METHODS: BV-2 cells (murine microglia), were stimulated by E. coli Lipopolysaccharide (LPS) and treated with rANXA1 in order to measure TSPO expression and inflammatory parameters. Anti-sense ANXA1 and TLR4 and TSPO shRNA, as well as pharmacological treatments, were employed to assess the mechanisms involved...
April 9, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29645305/evolution-of-a-xenobiotic-degradation-pathway-formation-and-capture-of-the-labile-phthaloyl-coa-intermediate-during-anaerobic-phthalate-degradation
#19
Mario Mergelsberg, Valentin Egle, Matthias Boll
Xenobiotic phthalates are industrially produced on the annual million ton scale. The oxygen-independent enzymatic reactions involved in anaerobic phthalate degradation have only recently been elucidated. In vitro assays suggested that phthalate is first activated to phthaloyl-CoA followed by decarboxylation to benzoyl-CoA. Here, we report the heterologous production and characterization of the enzyme initiating anaerobic phthalate degradation from 'Aromatoleum aromaticum': a highly specific succinyl-CoA:phthalate CoA transferase (SPT, class III CoA transferase)...
April 12, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29629264/echocardiographic-assessment-of-ventricular-septal-rupture-and-left-ventricular-aneurysm-after-inferior-and-posterior-myocardial-infarction
#20
Giuliana Pace, Gianfranco Filippone, Egle Corrado, Fabio Triolo, Vincenzo Argano, Salvatore Novo
We present a case of posterior ventricular septal rupture associated to left ventricular aneurysm manged, during peri-operative period, by transthoracic and transesophageal echocardiography. Three-dimensional transesophageal echocardiography findings add adjunctive and more accurate information regarding morphological details of the ventricular septal rupture rather than two-dimensional echocardiography, allowing, meanwhile, the detection of the outcome of the surgical repair.
January 2018: Journal of Cardiovascular Echography
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