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Intravenous ketamine

Hui Lin, Zhe Wang, Jinmei Shen, Junmei Xu, Hui Li
BACKGROUND: The current study was intended to investigate the effect of ketamine (KET) on complete Freund's adjuvant (CFA)-induced arthritis in rats. METHODS: The CFA was administered in the hind paw of the rats for the induction of adjuvant-induced arthritis. The paw swelling of experimental animals was measured as hind paw volume. Hematoxylin and eosin staining was estimated and pathological changes in the joint tissues were observed under a light microscope. Furthermore, the bicinchoninic acid assay was used for protein quantification...
November 30, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Kennett D Radford, Thomas Y Park, Shalini Jaiswal, Hongna Pan, Andrew Knutsen, Michael Zhang, Mercedes Driscoll, Lisa A Osborne-Smith, Bernard J Dardzinski, Kwang H Choi
Ketamine is a multimodal dissociative anesthetic, which provides powerful analgesia for victims with traumatic injury. However, the impact of ketamine administration in the peri-trauma period on the development of post-traumatic stress disorder (PTSD) remains controversial. Moreover, there is a major gap between preclinical and clinical studies because they utilize different doses and routes of ketamine administration. Here, we investigated the effects of sub-anesthetic doses of intravenous (IV) ketamine infusion on fear memory and brain glucose metabolism (BGluM) in rats...
November 30, 2018: Translational Psychiatry
Mohammad Ali Sahmeddini, Mohammad Bagher Khosravi, Arash Farbood
INTRODUCTION AND AIMS: Patients with opioid use disorder experience great challenges during acute pain management due to opioid tolerance or withdrawal symptoms. Previous studies have recommended the use of adjuvant drugs in these patients. In this study, we compared the effect of intraoperative lidocaine with ketamine in postoperative pain management of these patients. DESIGN AND METHODS: In this randomized clinical trial, 180 patients with opioid use disorder who underwent orthopedic surgery under general anesthesia were randomly allocated into 3 groups...
November 28, 2018: Journal of Addiction Medicine
Fei Yang, Yang Liu, Qing Yu, Shangyingying Li, Jin Zhang, Mang Sun, Lu Liu, Yao Lei, Qing Tian, Hui Liu, Shengfen Tu
BACKGROUND: Intranasal procedural sedation using dexmedetomidine is well described in the literature. The combination of intranasal dexmedetomidine and ketamine is a novel approach for which there are little data on the rate of successful sedation or adverse events. OBJECTIVES: The aim of this study is to evaluate the rate of successful sedation and adverse events of intranasal procedural sedation using a combination of dexmedetomidine and ketamine for diagnostic examination in children...
November 28, 2018: Paediatric Anaesthesia
Luca Bellini, Giulia Maria De Benedictis
Few reports evaluate the clinical effects of opioids in sheep during experimental surgical procedures. Catecholamine-mediated haemodynamic changes resulting from surgical noxious stimulation are blunted by opioids. The aim of this study was to evaluate the efficacy of three opioid-based analgesic protocols in avoiding a 20% increase in heart rate (HR) and/or mean arterial blood pressure (MAP) during experimental intervertebral disk nucleotomy in sheep. Eighteen female Brogna sheep were anaesthetized with propofol and maintained with a fixed end-tidal isoflurane concentration of 1...
November 27, 2018: Laboratory Animals
Corey Heitz, Justin Morgenstern, Christopher Bond, William K Milne
Ketamine has been studied as an alternative to opioids for acute pain in the emergency department setting. This review compares the effectives of intravenous ketamine at a dose of <0.5mg/kg to opioids for acute pain in adult patients. Measurements were taken within 60 minutes of administration. Ketamine was found to have similar effectiveness to opioids. Increased, but short-lived, side effects were seen with ketamine.
November 27, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Guillaume Dewe, Arnaud Steyaert, Marc De Kock, Fernande Lois, Raymond Reding, Patrice Forget
OBJECTIVE: Living donor hepatectomy (LDH) has important consequences in terms of acute and chronic pain. We proposed an anesthetic protocol based on the best currently available evidence. We report the results of this protocol's application. RESULTS: We performed a retrospective descriptive study of 100 consecutive donors undergoing LDH. The protocol included standardized information provided by the anesthetist, pharmacological anxiolysis and preventive analgesia...
November 26, 2018: BMC Research Notes
Rachael Dawson, Andrew Wignell, Paul Cooling, David Barrett, Harish Vyas, Patrick Davies
BACKGROUND: Plasma-Lyte 148 ® is a balanced, crystalloid intravenous (IV) fluid which is both calcium-free and isotonic. It prevents the hyperchloraemic metabolic acidosis and iatrogenic hyponatraemia seen with use of 0.9% sodium chloride and hypotonic solutions respectively. However, data on compatibility with commonly used drugs is lacking. AIM: To investigate the stability of Plasma-Lyte 148 ® and Plasma-Lyte 148 ® + 5% Glucose with eight commonly used therapeutic agents when compared with 5% Glucose and 0...
November 25, 2018: Paediatric Anaesthesia
Mei-Yi Lee, Yu-Ching Hsiao, Ming-Huan Chan, Hwei-Hsien Chen
BACKGROUND: Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. A case report has demonstrated that a ketamine addict experienced a significant reduction in craving and ketamine use after taking lamotrigine. The present study determined whether lamotrigine can reduce the motivation for ketamine and prevent the relapse to ketamine seeking behavior in rats. METHODS: Male Sprague-Dawley rats were trained to respond for intravenous ketamine (0...
November 15, 2018: Drug and Alcohol Dependence
S Pratt, A Cunneen, N Perkins, T Farry, L Kidd, M McEwen, J Rainger, G Truchetti, W Goodwin
BACKGROUND: There is no information directly comparing midazolam with guaifenesin when used in combination with an alpha-2 agonist and ketamine to maintain anaesthesia via intravenous (i.v.) infusion in horses. OBJECTIVES: To compare ketamine-medetomidine-guaifenesin with ketamine-medetomidine-midazolam for total intravenous anaesthesia in young horses anaesthetised for computerised tomography. STUDY DESIGN: Prospective, randomised, blinded, crossover trial...
November 19, 2018: Equine Veterinary Journal
Bashkim Kadriu, Laura Musazzi, Ioline D Henter, Morgan Graves, Maurizio Popoli, Carlos A Zarate
The underlying neurobiological basis of major depressive disorder (MDD) remains elusive due to the severity, complexity, and heterogeneity of the disorder. While the traditional monoaminergic hypothesis has largely fallen short in its ability to provide a complete picture of MDD, emerging preclinical and clinical findings suggest that dysfunctional glutamatergic neurotransmission may underlie the pathophysiology of both MDD and bipolar depression. In particular, recent studies showing that a single intravenous infusion of the glutamatergic modulator ketamine elicits fast-acting, robust, and relatively sustained antidepressant, anti-suicidal, and anti-anhedonic effects in individuals with treatment-resistant depression (TRD) have prompted tremendous interest in understanding the mechanisms responsible for ketamine's clinical efficacy...
November 16, 2018: International Journal of Neuropsychopharmacology
T Hamp, J Baron-Stefaniak, M Krammel, B Reiter, A Langauer, T Stimpfl, W Plöchl
BACKGROUND: Ketamine is routinely used in operating theatres, emergency departments, ICUs, and even outpatient units. Despite the widespread use of ketamine, only basic aspects of its interactions with inhalation anaesthetic agents are known, and formal testing of interactions in humans is lacking. The minimum alveolar concentration (MAC) of inhalation anaesthetics is used to guide the depth of anaesthesia, and several drugs are known to influence the MAC. The aim of this study was to investigate whether intravenous application of ketamine influences the MAC of sevoflurane in humans...
December 2018: British Journal of Anaesthesia
Ashley R Etchison, Lia Bos, Meredith Ray, Kelly B McAllister, Moiz Mohammed, Barrett Park, Allen Vu Phan, Corey Heitz
Introduction: Patients frequently present to the emergency department (ED) with migraine headaches. Although low-dose ketamine demonstrates analgesic efficacy for acute pain complaints in the ED, headaches have historically been excluded from these trials. This study evaluates the efficacy and safety of low-dose ketamine for treatment of acute migraine in the ED. Methods: This randomized, double-blinded, placebo-controlled trial evaluated adults 18 to 65 years of age with acute migraine at a single academic ED...
November 2018: Western Journal of Emergency Medicine
Yaofei Jiang, Ruoxi Chen, Suming Xu, Jiaxi Li, Fanqi Yu, Lingdong Kong, Yuhan Sun, Yuan Ye, Yimin Li, Mengqi Yu, Jiaming Wu
Background/Aims: An updated systematic review and meta-analysis was conducted to assess the effect of prophylactic dexamethasone for tracheal intubation of general anesthesia on postoperative sore throat (POST). Methods: Comprehensive literature search of databases for randomized controlled trials (RCTs), including Embase, PubMed, and Cochrane Library, which evaluate the effect of prophylactic dexamethasone on POST was conducted. RevMan 5.0 and STATA 12.0 software were used to perform meta-analyses...
2018: Journal of Pain Research
Stefan Wirz, Michael Schenk, Kristin Kieselbach
Due to preexisting pain or surgically induced sensitization patients undergoing oncological surgery are predisposed for a postoperative high pain intensity with the risk of developing persistent pain. In oncological surgery, pain therapy should be adapted to the underlying pain mechanism. Different treatment principles should be applied in a graded concept of acute pain therapy. The rationale implies the "conventional" use of the WHO step scheme, the administration of opioids as PCA as well as regional analgesia and agents with anti-hypersensitizing properties...
October 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Katherine R Forrester, Scott M Thomas, Nita K Gupta, Manasa Karumuri, James M Gerard
BACKGROUND: Patients undergoing procedural sedation with intravenous ketamine often receive repeat doses to maintain dissociation; however, data between doses are lacking. OBJECTIVES: The purpose of this study was to characterize the frequency, time interval, and dosages of ketamine received by children undergoing procedural sedation and to explore the effects of age and body mass index on these parameters. METHODS: This was a retrospective study of patients 1 to 18 years of age undergoing procedural sedation with intravenous ketamine in a pediatric emergency department between October 2016 and June 2017...
November 8, 2018: Journal of Emergency Medicine
Hirotaka Tokushige, Atsushi Okano, Daisuke Arima, Hideki Ito, Yoshinori Kambayashi, Yohei Minamijima, Minoru Ohta
BACKGROUND: The aim of the present study was to evaluate clinical efficacy of constant rate infusions (CRIs) of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery. Thirty horses were sedated intravenously (IV) with medetomidine (6.0 μg/kg) and midazolam (0.02 mg/kg) and induced IV with ketamine (1.0 mg/kg) and propofol (1.0 mg/kg). These horses were randomly allocated to three groups and maintained with sevoflurane and CRI of either medetomidine (3...
November 5, 2018: Acta Veterinaria Scandinavica
Nihar Ameta, Mathews Jacob, Shahbaz Hasnain, Gaurishankar Ramesh
Background and Aims: Shivering after spinal anesthesia is a common complication and can occur in as many as 40%-70% of patients after regional anesthesia. This shivering, apart from its physiological and hemodynamic effects, has been described as even worse than surgical pain. The aim of the study was to evaluate and compare the effectiveness of prophylactic use of intravenous (IV) ketamine, dexmedetomidine, and tramadol for prevention of shivering after spinal anesthesia. Material and Methods: Two hundred American Society of Anesthesiologists physical status I and II patients subjected to spinal anesthesia were included in the study...
July 2018: Journal of Anaesthesiology, Clinical Pharmacology
Jessica Sexton, Rabia S Atayee, Heather C Bruner
Patients with advanced cancer often suffer from both severe pain and severe symptoms of depression. Use of traditional antidepressants is often limited by the short prognosis associated with advanced cancer. We present the case of a patient with neuropathic pain from advanced cancer and severe depression that responded dramatically to an intravenous infusion of ketamine resulting in decreased pain and resolution of severe depression symptoms.
November 2018: Journal of Palliative Medicine
M Steffens, C Neumann, A-M Kasparbauer, B Becker, B Weber, M A Mehta, R Hurlemann, U Ettinger
INTRODUCTION: The uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist ketamine has been proposed to model symptoms of psychosis. Inhibitory deficits in the schizophrenia spectrum have been reliably reported using the antisaccade task. Interestingly, although similar antisaccade deficits have been reported following ketamine in non-human primates, ketamine-induced deficits have not been observed in healthy human volunteers. METHODS: To investigate the effects of ketamine on brain function during an antisaccade task, we conducted a double-blind, placebo-controlled, within-subjects study on n = 15 healthy males...
December 2018: Psychopharmacology
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