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Intravenous ketamine

E Halbeck, C Dumps, D Bolkenius
No abstract text is available yet for this article.
October 19, 2018: Der Anaesthesist
C Forster, A Vanhaudenhuyse, P Gast, E Louis, G Hick, J-F Brichant, J Joris
BACKGROUND: Propofol use during sedation for colonoscopy can result in cardiopulmonary complications. Intravenous lidocaine can alleviate visceral pain and decrease propofol requirements during surgery. We tested the hypothesis that i.v. lidocaine reduces propofol requirements during colonoscopy and improves post-colonoscopy recovery. METHODS: Forty patients undergoing colonoscopy were included in this randomised placebo-controlled study. After titration of propofol to produce unconsciousness, patients were given i...
November 2018: British Journal of Anaesthesia
Leorey N Saligan, Cristan Farmer, Elizabeth D Ballard, Bashkim Kadriu, Carlos A Zarate
BACKGROUND: Fatigue and depression are closely associated. The purpose of this secondary analysis was to understand the relationships between depression and improvements in specific depression domains on the anti-fatigue effects of ketamine, which we previously reported. METHODS: This secondary analysis re-evaluated data collected longitudinally from 39 patients with treatment-resistant Major Depressive Disorder (MDD) enrolled in a double-blind, randomized, placebo-controlled, crossover trial using a single intravenous infusion of ketamine hydrochloride (0...
October 6, 2018: Journal of Affective Disorders
Palanisamy Nagalakshmi, Sundararajan Leo, S Uthirapathi
Background: Management of airway is of great importance in the practice of anesthesia. Supraglottic airway devices, such as laryngeal mask airway (LMA), have greatly revolutionized the management of airway both in terms of ease and degree of invasiveness. Propofol, by its inherent property of decreasing airway reflexes, is used to aid in LMA insertion. In this study, we have evaluated the LMA insertion conditions and hemodynamic stability, comparing butorphanol, fentanyl, and ketamine as co-induction agents with propofol...
July 2018: Anesthesia, Essays and Researches
Maurizio Fava, Marlene P Freeman, Martina Flynn, Heidi Judge, Bettina B Hoeppner, Cristina Cusin, Dawn F Ionescu, Sanjay J Mathew, Lee C Chang, Dan V Iosifescu, James Murrough, Charles Debattista, Alan F Schatzberg, Madhukar H Trivedi, Manish K Jha, Gerard Sanacora, Samuel T Wilkinson, George I Papakostas
Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 min). However, the optimal antidepressant dose remains unknown. We aimed to compare to active placebo the rapid acting antidepressant properties of a broad range of subanesthetic doses of IV ketamine among outpatients with treatment-resistant depression (TRD)...
October 3, 2018: Molecular Psychiatry
Wei Zheng, Yan-Ling Zhou, Wei-Jian Liu, Cheng-Yu Wang, Yan-Ni Zhan, Han-Qiu Li, Li-Jian Chen, Ming Ding Li, Yu-Ping Ning
OBJECTIVE: Single-dose intravenous (IV) injection of ketamine has shown rapid but transient antidepressant effects. The strategy of repeated-dose ketamine infusions to maintain antidepressant effects has received little systematic study. This study was conducted to examine the efficacy and tolerability of six ketamine infusions in Chinese patients with unipolar and bipolar depression. METHODS: Ninety seven patients with unipolar (n = 77) and bipolar (n = 20) depression received repeated ketamine infusions (0...
September 25, 2018: Journal of Psychiatric Research
Işın Güneş, Nuran Süngü, Aydan Kılıçarslan, Volkan Şıvgın, Metin Alkan, Ayşegül Küçük, Hakan Boyunağa, Yusuf Ünal, Mustafa Arslan
Objective: This study was conducted since the effects of colloid solutions on the renal system remain controversial and need to be adequately studied in animals. We aimed to evaluate the effects of hydroxyethyl starch (Voluven) on the kidney tissue of rats with late renal failure due to ureteral obstruction. Materials and methods: Rats were divided into four groups: Group C, control; Group HES, hydroxyethyl starch solution (HES) 130/0.4 (Voluven® ); Group UUO, unilateral ureteral obstruction (UUO); and Group UUO-HES, UUO-HES 130/0...
2018: Drug Design, Development and Therapy
Chadi G Abdallah, Arpan Dutta, Christopher L Averill, Shane McKie, Teddy J Akiki, Lynnette A Averill, J F William Deakin
Background: Identifying the neural correlates of ketamine treatment may facilitate and expedite the development of novel, robust, and safe rapid-acting antidepressants. Prefrontal cortex (PFC) global brain connectivity with global signal regression (GBCr) was recently identified as a putative biomarker of major depressive disorder (MDD). Accumulating evidence have repeatedly shown reduced PFC GBCr in MDD, an abnormality which appears to normalize following ketamine treatment. Methods: Fifty-six unmedicated participants with MDD were randomized to intravenous placebo (normal saline; n = 18), ketamine (0...
January 2018: Chronic Stress
Adrianna M Sage, Stephanie Cj Keating, Kara M Lascola, David J Schaeffer, Stuart C Clark-Price
OBJECTIVE: To evaluate cardiopulmonary and recovery characteristics of horses administered total intravenous anesthesia (TIVA) with xylazine and ketamine combined with midazolam or propofol. STUDY DESIGN: Randomized crossover study. ANIMALS: A group of eight adult horses, aged 7-22 years, weighing 493-740 kg. METHODS: Horses were administered xylazine (1 mg kg-1 ) intravenously (IV), and anesthesia was induced with ketamine (2...
August 11, 2018: Veterinary Anaesthesia and Analgesia
Yanling Zhou, Wei Zheng, Weijian Liu, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Mingding Li, Yuping Ning
BACKGROUND: Ketamine has proven to have rapid, robust antidepressant effects on treatment-resistant depression. However, whether repeated ketamine infusions would cause short-and long-term neurocognitive impairments was not clear. Our aims were to investigate the neurocognitive effects of six ketamine infusions and to examine the association between these infusions and the antidepressant response in patients with unipolar and bipolar depression. METHODS: Six intravenous infusions of ketamine (0...
September 27, 2018: Journal of Psychopharmacology
Pyoyoon Kang, Sun-Kyung Park, Seokha Yoo, Min Hur, Won H Kim, Jin-Tae Kim, Jae-Hyon Bahk
INTRODUCTION: Although many drugs have been studied to prevent postoperative shivering, their comparative effectiveness is unknown. We attempted to assess the comparative effectiveness of the pharmacologic strategies to prevent shivering after surgery including intravenous (IV) and intrathecal (IT) meperidine, IV and IT dexmedetomidine, IV and IT clonidine, nefopam, tramadol, ketamine, and serotonin receptor antagonists. EVIDENCE ACQUISITION: We implemented a frequentist network meta-analysis of randomised trials...
September 18, 2018: Minerva Anestesiologica
Hiroyuki Seki, Satoshi Ideno, Taiga Ishihara, Kota Watanabe, Morio Matsumoto, Hiroshi Morisaki
Posterior spinal fusion for adolescent idiopathic scoliosis is one of the most invasive surgical procedures performed in children and adolescents. Because of the extensive surgical incision and massive tissue trauma, posterior spinal fusion causes severe postoperative pain. Intravenous patient-controlled analgesia with opioids has been the mainstay of postoperative pain management in these patients. However, the use of systemic opioids is sometimes limited by opioid-related side effects, resulting in poor analgesia...
2018: Scoliosis and Spinal Disorders
Yanling Zhou, Wei Zheng, Weijian Liu, Chengyu Wang, Yanni Zhan, Hanqiu Li, Lijian Chen, Mingding Li, Yuping Ning
Ketamine has rapid antidepressant effects on treatment-resistant depression, but the biological mechanism underpinning this effect is less clear. Our aims were to examine whether kynurenine pathway metabolites were altered by six infusions of ketamine and whether these biological factors could act as potential biomarkers to predict ketamine's antidepressant effects. Six intravenous infusions of ketamine (0.5 mg/kg) were administered to 84 patients with unipolar and bipolar depression over a 12-d period. Symptom severity and response were assessed using the Montgomery-Asberg Scale (MADRS), and blood samples were collected at baseline and 24 hours following the first infusion and at 24 hours and 14 d after the sixth infusion (24 hours, 13 d and 26 d)...
September 10, 2018: Brain, Behavior, and Immunity
Rachael L Bosma, Joshua C Cheng, Anton Rogachov, Junseok A Kim, Kasey S Hemington, Natalie R Osborne, Lakshmikumar Venkat Raghavan, Anuj Bhatia, Karen D Davis
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Ketamine is an N-methyl-D-aspartate receptor antagonist that reduces temporal summation of pain and modulates antinociception. Ketamine infusions can produce significant relief of neuropathic pain, but the treatment is resource intensive and can be associated with adverse effects. Thus, it is crucial to select patients who might benefit from this treatment. The authors tested the hypothesis that patients with enhanced temporal summation of pain and the capacity to modulate pain via the descending antinociceptive brain pathway are predisposed to obtain pain relief from ketamine...
November 2018: Anesthesiology
Farzan Kheirkhah, Gooya Tayyebi, Seyed Mozaffar Rabiee, Ali-Akbar Moghadamnia, Ali Bijani
Background: Major depressive disorder is a severe, heterogeneous, common medical illness and a leading cause of disability throughout the world that poses a significant public health issue. Previous studies have shown rapid antidepressant effects following a single administration of ketamine. This study aimed to assess the impact of route of administration and dose of ketamine for the reduction of depressive symptoms and compare the effects of different doses and methods. Methods: A double-blind clinical controlled trial was done on 100 patients with a primary diagnosis of major depressive disorder who were assigned into two groups of 50 subjects at a dose of 0...
2018: Caspian Journal of Internal Medicine
Phillip G Brennan, James K Landry, M Victoria P Miles, Alicia C Lintner, Kaitlin A McGinn, Steven A Kahn
Little has been published regarding intravenous (IV) ketamine for burn wound care in adult patients. Ketamine may serve as a safe alternative to provide conscious sedation and limit opioid administration to patients. The purpose of this study was to characterize IV ketamine use during burn wound care and establish its potential role as a safe adjunct to opioid and benzodiazepine medications. This is a retrospective review of adult patients admitted to a regional burn center who received IV ketamine for burn wound care...
September 5, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Rejish K Thomas, Glen Baker, John Lind, Serdar Dursun
BACKGROUND: Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains understudied. AIMS: This study aims to measure the response and remission rates in ultraresistant depression patients in a clinical setting by means of a retrospective, open label, database study...
September 5, 2018: Journal of Psychopharmacology
Sergey Motov, Jefferson Drapkin, Antonios Likourezos, Joshua Doros, Ralph Monfort, John Marshall
BACKGROUND: We describe our experience of utilizing sub-dissociative dose ketamine (SDK) in managing a variety of acute and chronic painful conditions in the emergency department (ED). METHODS: A descriptive study was conducted in our ED over a period of seven years (2010-2016) by retrospectively reviewing charts of patients aged 18 and older presenting to the ED with painful complaints and receiving SDK analgesia. Primary data analyses included type of SDK administration (intravenous push [IVP], short-infusion [SI] or continuous infusion [CI]), dosing, rates of analgesic utilization before and after SDK administration, and adverse effects...
2018: World Journal of Emergency Medicine
Nitin Hayaran, Rohit Malhotra, Swati Tyagi, Aruna Jain
Acute fatty liver of pregnancy is one of the most common causes of fulminant hepatic failure. A 28-year-old G3P1L1A1 presented at 37 weeks with diagnosis of acute fatty liver of pregnancy with grade 3 hepatic encephalopathy. Laboratory findings were suggestive of coagulopathy, metabolic acidosis, and liver and renal dysfunction. Ultrasound-guided transversus abdominis plane block with ilioinguinal-iliohypogastric nerve block is widely used for postoperative analgesia. We applied these blocks, supplemented with intravenous ketamine for breakthrough visceral pain, to conduct cesarean delivery with a favorable outcome...
August 29, 2018: A&A practice
Yang Zhou, Yuming Peng, Jinghan Fang, Wanchen Sun, Guofu Zhang, Long Zhen, Gang Wang, Ruquan Han
BACKGROUND: Perioperative depressive symptoms (PDS) are common mental comorbidities that influence clinical outcomes and prognosis. However, there is no rapid-acting treatment to address these symptoms during a limited hospital stay. METHODS/DESIGN: This is a single-center, randomized, placebo-controlled, and double-blind trial. Randomization will be applied and stratified by the severity of PDS (moderate versus severe). Eighty patients who are scheduled for elective supratentorial brain tumor resection with PDS will be randomly allocated to the ketamine or placebo group with a ratio of 1 to 1...
August 29, 2018: Trials
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