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Non-alcoholic fatty liver

Noam Peleg, Orly Sneh Arbib, Assaf Issachar, Michal Cohen-Naftaly, Marius Braun, Amir Shlomai
BACKGROUND: Liver fibrosis predicts liver-related morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD). Non-invasive scores correlate with the degree of liver fibrosis in these patients. AIMS AND METHODS: To investigate the accuracy of noninvasive scoring systems in predicting long-term outcomes and cancer incidence of patients with NAFLD, we performed a single-center retrospective study of patients with biopsy proven NAFLD. Mean follow up period was 100 months...
2018: PloS One
H-B Kim, H-S Lee, Y-J Lee
OBJECTIVE: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. METHODS: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, ≤46.4 ng/ml; T2, 46.5-76.1 ng/ml; and T3, ≥76.2 ng/ml. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated after adjusting for confounding variables across serum ferritin tertiles using multiple logistic regression analysis...
August 14, 2018: Climacteric: the Journal of the International Menopause Society
Pirjo Käkelä, Ville Männistö, Maija Vaittinen, Sari Venesmaa, Vesa Kärjä, Kirsi Virtanen, Hannu Paajanen, Jussi Pihlajamäki
BACKGROUND AND AIMS: Different bariatric procedures have been associated with variable weight loss and decrease in serum levels of lipids and lipoproteins. This variation could be partly related to the length of the small intestinal bypass. We evaluated the association of the small intestinal length with the non-alcoholic fatty liver disease (NAFLD) at baseline and with lipid metabolism before and after laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: Seventy consecutive morbidly obese patients were recruited to this prospective study...
August 13, 2018: Obesity Surgery
Yun Kyung Cho, Yu Mi Kang, Jee Hee Yoo, Jiwoo Lee, Seung Eun Lee, Dong Hyun Yang, Joon-Won Kang, Joong-Yeol Park, Chang Hee Jung, Hong-Kyu Kim, Woo Je Lee
It is unclear whether non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease. We examined the independent impact of NAFLD on the progression of the coronary artery calcification (CAC) score, a well-known marker of atherosclerosis progression. We examined 1,173 asymptomatic participants who underwent repeated CAC score measurement during routine health examinations. The subjects were categorised into four groups based on the presence (+) or absence (-) of NAFLD and metabolic syndrome (MetS)...
August 13, 2018: Scientific Reports
Marcela Parra-Vargas, Ana Sandoval-Rodriguez, Roberto Rodriguez-Echevarria, Jose Alfredo Dominguez-Rosales, Arturo Santos-Garcia, Juan Armendariz-Borunda
Anthocyanin consumption is linked to benefits in obesity-related metabolic alterations and non-alcoholic fatty liver disease (NAFLD), though the functional role of delphinidin (Dp) is yet to be established. Therefore, this study examined the effects of Dp on metabolic alterations associated with NAFLD, and molecular mechanisms in HepG2 cells and diet-induced obese mice. Cells incubated with palmitate to induce lipid accumulation, concomitantly treated with Dp, reduced triglyceride accumulation by ~53%, and downregulated gene expression of CPT1A , SREBF1 , and FASN without modifying AMP-activated protein kinase (AMPK) levels...
August 10, 2018: Nutrients
Dorothee Kübel, Maximilian Tiller, Tobias Mühling, Maximilian Sohn, Inka Vallbracht, Birgit Waschulzik, Wolfgang Schepp, Felix Gundling
INTRODUCTION:  Systemic lupus erythematodes (SLE) represents an autoimmune disease with a highly variable clinical course affecting numerous organs. Hepatic manifestation seems to be rare. It is not clear whether hepatic disease in SLE is of any prognostic importance or whether it correlates with disease activity. METHODS:  Our patient cohort included 172 patients with proven SLE, all treated at Bogenhausen Hospital between 01.2009 and 12.2015. Retrospectively, all admissions as inpatients and outpatients were analyzed (n = 671; mean 3...
August 13, 2018: Zeitschrift Für Gastroenterologie
Xiaojing Wang, Marcelle Ribeiro, Arvin Iracheta-Vellve, Patrick Lowe, Aditya Ambade, Abhishek Satishchandran, Terence Bukong, Donna Catalano, Karen Kodys, Gyongyi Szabo
Inflammatory cell activation drives diverse cellular programming during hepatic diseases. Hypoxia-inducible factors (HIFs) have recently been identified as important regulators of immunity and inflammation. In non-alcoholic steatohepatitis (NASH), HIF-1α is upregulated in hepatocytes where it induces steatosis; however, the role of HIF-1α in macrophages under metabolic stress has not been explored. In this study, we found increased HIF-1α levels in hepatic macrophages in methionine-choline-deficient (MCD) diet-fed mice and in macrophages of NASH patients compared to controls...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Laure Monteillet, Monika Gjorgjieva, Marine Silva, Vincent Verzieux, Linda Imikirene, Adeline Duchampt, Hervé Guillou, Gilles Mithieux, Fabienne Rajas
OBJECTIVE: Ectopic lipid accumulation in the liver and kidneys is a hallmark of metabolic diseases leading to non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). Moreover, recent data have highlighted a strong correlation between NAFLD and CKD incidences. In this study, we use two mouse models of hepatic steatosis or CKD, each initiated independently of the other upon the suppression of glucose production specifically in the liver or kidneys, to elucidate the mechanisms underlying the development of CKD in the context of NAFLD-like pathology...
August 1, 2018: Molecular Metabolism
Myriam Alexander, A Katrina Loomis, Jolyon Fairburn-Beech, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Paul Avillach, Peter Egger, Stuart Kendrick, Dawn M Waterworth, Naveed Sattar, William Alazawi
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. It affects an estimated 20% of the general population, based on cohort studies of varying size and heterogeneous selection. However, the prevalence and incidence of recorded NAFLD diagnoses in unselected real-world health-care records is unknown. We harmonised health records from four major European territories and assessed age- and sex-specific point prevalence and incidence of NAFLD over the past decade...
August 13, 2018: BMC Medicine
Chaonan Xu, Zhimin Ma, Yunfeng Wang, Xiangtong Liu, Lixin Tao, Deqiang Zheng, Xiuhua Guo, Xinghua Yang
BACKGROUND & AIMS: Although evidence indicates that visceral adipose tissue is associated with non-alcoholic fatty liver disease (NAFLD), it is unclear whether the visceral adiposity index (VAI) can predict the incidence of NAFLD. This study aimed to determine if the VAI is an independent risk factor of NAFLD and if there is a dose-response relationship. METHODS: We explored the relationship between VAI levels and NAFLD in a health check-up cohort established in 2012...
August 12, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Kostiantyn V Tarasenko, Antonina M Gromova, Kateryna V Pikul, Ruslan B Lysenko, Leonid A Nesterenko
OBJECTIVE: Introduction: Obesity is one of the most important medical and social problems in many countries of the world, as it is associated with the development of the most common non-communicable diseases: cardiovascular, type II diabetes mellitus, motor disorders, non-alcoholic fatty liver disease (NHAHP) and others. The aim of this paper is to analyze the pathogenetic mechanisms of insulin resistance development in pregnant women with varying obesity degrees in early and late gestation periods...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Charlotte J Green, Siôn A Parry, Pippa J Gunn, Carlo D L Ceresa, Fredrik Rosqvist, Marie-Eve Piché, Leanne Hodson
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Determining the pathogenesis and pathophysiology of human NAFLD will allow for evidence-based prevention strategies, and more targeted mechanistic investigations. Various in vivo, ex situ and in vitro models may be utilised to study NAFLD; but all come with their own specific caveats. Here, we review the human-based models and discuss their advantages and limitations in regards to studying the development and progression of NAFLD. Overall, in vivo whole-body human studies are advantageous in that they allow for investigation within the physiological setting, however, limited accessibility to the liver makes direct investigations challenging...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
Edward S Chambers, Claire S Byrne, Annette Rugyendo, Douglas J Morrison, Tom Preston, M Catriona Tedford, Jimmy D Bell, E Louise Thomas, Arne N Akbar, Natalie E Riddell, Rohini Sharma, Mark R Thursz, Pinelopi Manousou, Gary Frost
The short chain fatty acid (SCFA) propionate, produced through fermentation of dietary fibre by the gut microbiota, has been shown to alter hepatic metabolic processes that reduce lipid storage. We aimed to investigate the impact of raising colonic propionate production on hepatic steatosis in adults with non-alcoholic fatty liver disease (NAFLD). Eighteen adults were randomised to receive 20g/day of an inulin-propionate ester (IPE), designed to deliver propionate to the colon, or an inulin-control for 42-days in a parallel design...
August 11, 2018: Diabetes, Obesity & Metabolism
Konstantinos Assimakopoulos, Katerina Karaivazoglou, Evangelia-Eirini Tsermpini, Georgia Diamantopoulou, Christos Triantos
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent medical condition, which may lead to severe complications including cirrhosis and hepatocellular carcinoma. Its chronic course and its association with obesity and diabetes mellitus augment the long-term impact of NAFLD on patients' health and quality of life (QoL) and put great strain on healthcare systems worldwide. Research is growingly focusing on NAFLD patients' QoL in an attempt to describe the full spectrum of disease burden and tackle its future consequences...
September 2018: Journal of Psychosomatic Research
Zhou-Feng Chen, Xiu-Li Dong, Qing-Ke Huang, Wang-Dong Hong, Wen-Zhi Wu, Jian-Sheng Wu, Shuang Pan
BACKGROUND: This research aimed to investigate whether metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) had both individual and synergistic effects on the prognosis for female colorectal carcinoma (CRC) patients. METHODS: The relationship between CRC prognosis and NAFLD as well as MetS was evaluated in 764 female participants. Based on the NAFLD level, patients were divided into significant NAFLD (SNAFLD), "moderate" and "severe" level, and non-SNAFLD, "non" and "mild" level...
August 10, 2018: World Journal of Surgical Oncology
Raghdaa Hamdan Al Zarzour, Mohammed A Alshawsh, Muhammad Asif, Majed Ahmed Al-Mansoub, Zahurin Mohamed, Mariam Ahmad, Amin Malik Shah Abdul Majid, Mohd Zaini Asmawi, Gurjeet Kaur, Dhamraa Waleed Al-Dualimi, Mun Fei Yam
The growth of adipose tissues is considered angiogenesis-dependent during non-alcoholic fatty liver disease (NAFLD). We have recently reported that our standardized 50% methanolic extract (ME) of Phyllanthus niruri (50% ME of P. niruri ) has alleviated NAFLD in Sprague⁻Dawley rats. This study aimed to assess the molecular mechanisms of action, and to further evaluate the antiangiogenic effect of this extract . NAFLD was induced by eight weeks of high-fat diet, and treatment was applied for four weeks. Antiangiogenic activity was assessed by aortic ring assay and by in vitro tests...
August 9, 2018: Nutrients
Lino Arisqueta, Hiart Navarro-Imaz, Ibone Labiano, Yuri Rueda, Olatz Fresnedo
High fat diet (HFD) feeding or leptin deficient mice are extensively used as models resembling features of human non-alcoholic fatty liver disease (NAFLD). The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances. In this work, we characterized the hepatic lipid accumulation induced by HFD in wild type (Wt) and ob/ob mice with the purpose of differentiating adaptations to HFD from those specific of increased overfeeding due to leptin deficiency-associated hyperphagia...
August 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
A M Coates, A M Hill, S Y Tan
PURPOSE OF REVIEW: We review recent epidemiological and clinical studies investigating the consumption of tree nuts and peanuts and cardiovascular disease (CVD) mortality as well as CVD risk factors. RECENT FINDINGS: A greater consumption of tree nuts and peanuts is associated with a reduced risk of CVD mortality, as well as lower CVD events. Furthermore, risk factors associated with the development of CVD such as dyslipidemia, impaired vascular function, and hypertension are improved with regular tree nut and peanut consumption through a range of mechanism associated with their nutrient-rich profiles...
August 9, 2018: Current Atherosclerosis Reports
J A Sargeant, L J Gray, D H Bodicoat, S A Willis, D J Stensel, M A Nimmo, G P Aithal, J A King
This systematic review and meta-analysis determined the impact of structured exercise training, and the influence of associated weight loss, on intrahepatic triglyceride (IHTG) in individuals with non-alcoholic fatty liver disease (NAFLD). It also examined its effect on hepatic insulin sensitivity in individuals with or at increased risk of NAFLD. Analyses were restricted to studies using magnetic resonance spectroscopy or liver biopsy for the measurement of IHTG and isotope-labelled glucose tracer for assessment of hepatic insulin sensitivity...
August 9, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
James E Klaunig, Xilin Li, Zemin Wang
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty liver disease involves the accumulation of hepatocellular fat in hepatocytes that can progress to hepatitis. Steatohepatitis is categorized into alcoholic (ASH) or non-alcoholic (NASH) steatohepatitis based on the etiology of the insult. Both pathologies involve an initial steatosis followed by a progressive inflammation of the liver and eventual hepatic fibrosis (steatohepatitis) and cirrhosis. The involvement of pharmaceuticals and other chemicals in the initiation and progression of fatty liver disease has received increased study...
July 1, 2018: Toxicology Research
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