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Gamete donation

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https://www.readbyqxmd.com/read/30036373/rethinking-gamete-donor-care-a-satisfaction-survey-of-egg-and-sperm-donors-in-the-uk
#1
Richard A Williams, Laura L Machin
OBJECTIVE: Despite poor clinic communication and staff treatment being reported by donors, high rates of overall satisfaction are still reported in surveys. This study will evaluate the importance of communication and interaction between donors and fertility clinic staff in gamete donor care. METHODS: We report on 120 egg and sperm donors' responses to a UK-wide online satisfaction survey. The survey focused on donors' interactions with fertility clinic staff pre-, during, and post- donation...
2018: PloS One
https://www.readbyqxmd.com/read/30031370/the-impact-of-sperm-and-egg-donation-on-the-risk-of-pregnancy-complications
#2
Michal Fishel Bartal, Baha M Sibai, Yossi Bart, Avi Shina, Shali Mazaki-Tovi, Irit Schushan Eisen, Israel Hendler, Micha Baum, Eyal Schiff
OBJECTIVE:  The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation. METHODS:  This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (SD) were included. Obstetrics and neonatal outcomes for pregnancies following single SD were compared with pregnancies following repeat SD from the same donor...
July 21, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29975790/the-mental-health-of-mothers-and-fathers-during-pregnancy-and-early-parenthood-after-successful-oocyte-donation-treatment-a-nested-case-control-study
#3
Mari Sälevaara, Raija-Leena Punamäki, Leila Unkila-Kallio, Mervi Vänskä, Maija Tulppala, Aila Tiitinen
INTRODUCTION: The aim of this study was to compare the mental health problems between parents after oocyte donation treatment, after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with own gametes and after naturally conceiving (NC). MATERIAL AND METHODS: This is a prospective, longitudinal questionnaire study. The study group consisted of 26 oocyte donation mothers and their matched IVF/ICSI (n = 52) and NC (n = 52) controls. Matching was performed according to mother's age, parity, type of pregnancy, and number of returned questionnaires...
July 5, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29872942/compensating-human-subjects-providing-oocytes-for-stem-cell-research-9-year-experience-and-outcomes
#4
L Zakarin Safier, A Gumer, M Kline, D Egli, M V Sauer
PURPOSE: Human oocytes are arguably one of the most important cell types in humans, yet they are one of the least investigated cells. Because oocytes are limited in number, the use of high-quality oocytes is almost entirely in reproduction. Furthermore, regulatory hurdles for research on gametes and regulations on funding related to research on gametes present significant obstacles to research and the advancement of reproductive treatments. Here we report the outcomes of the largest compensated oocyte donation program for research in the USA to date, and probably worldwide...
June 5, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29868183/trust-women-to-choose-a-response-to-john-a-robertson-s-egg-freezing-and-egg-banking-empowerment-and-alienation-in-assisted-reproduction
#5
Imogen Goold
In 'Egg Freezing and Egg Banking: Empowerment and Alienation in Assisted Reproduction', John A Robertson responds to the American Society of Reproductive Medicine's statement that oocyte preservation should no longer be considered an experimental treatment. He explores the implications of this development, focusing on the potentially empowering impact of oocyte preservation as a means for women to preserve their fertility. He also engages with concerns about the possibility that such a development may raise issues of alienation...
December 2017: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/29774274/sperm-donor-regulation-and-disclosure-intentions-results-from-a-nationwide-multi-centre-study-in-france
#6
N Kalampalikis, M Doumergue, S Zadeh
Gamete donation in Europe is not regulated by a common legal framework. Different laws regarding donor anonymity and remuneration exist in different countries. In France, gamete donation is characterized by a stable legal framework - the existing system of anonymous and non-remunerated donation remained unchanged following a period of public and parliamentary debate in 2011 - but little evidence is available concerning recipients' views and experiences of gamete donation. This article describes findings from a questionnaire completed individually by 714 heterosexual couple members undergoing a donor conception procedure at one of 20 national fertility centres in France...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774260/can-the-uk-s-birth-registration-system-better-serve-the-interests-of-those-born-following-collaborative-assisted-reproduction
#7
Marilyn A Crawshaw, Eric D Blyth, Julia Feast
Current birth registration systems fail to serve adequately the interests of those born as a result of gamete and embryo donation and surrogacy. In the UK, changes to the birth registration system have been piecemeal, reactive and situation-specific and no information is recorded about gamete donors. Birth registration has thereby become a statement of legal parentage and citizenship only, without debate as to whether it should serve any wider functions. This sits uneasily with the increasingly accepted human right to know one's genetic and gestational as well as legal parents, and the duty of the State to facilitate that right...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29734085/attitude-towards-reciprocity-as-a-motive-for-oocyte-donation
#8
Guido Pennings, Célia Ravel, Jean-Maxime Girard, Mathilde Domin-Bernhard, Veerle Provoost
OBJECTIVE: Finding out whether patients would be motivated by reciprocity when considering donating oocytes to others. STUDY DESIGN: This is a prospective monocentric study in the CECOS of the Centre Hospitalier Universitaire (CHU) of Rennes (France) on the opinion of patients regarding reciprocity. Couples who had a child with donor sperm were asked whether they would consider oocyte donation as a way of giving something back. RESULTS: Twenty six couples and one man answered the questionnaire...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29670338/preference-for-anonymity-in-sperm-donation-for-artificial-insemination-an-experience-from-low-resource-settings-in-nigeria
#9
Euzebus Chinonye Ezugwu, George U Eleje, Chukwuemeka A Iyoke, Sunday G Mba, Henry C Nnaji, Chukwunonso I Enechukwu, Peter O Nkwo
Objective: Anonymous sperm donation is a common practice in Nigeria with its associated legal and ethical challenges. This study aimed to investigate infertile couples' opinions about issues of sperm donor anonymity and to determine factors that might influence their preferences. Methods: A cross-sectional, multicentered, questionnaire-based study was conducted among infertile couples attending infertility clinics in three tertiary hospitals in the south-eastern region of Nigeria over a period of 6 months...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29605404/informing-offspring-of-their-conception-by-gamete-or-embryo-donation-an-ethics-committee-opinion
#10
(no author information available yet)
This document discusses the ethical implications of informing offspring about their conception using gamete or embryo donation. It replaces the 2013 ASRM Ethics Committee document of the same name (Fertil Steril 2013;100:45-9).
April 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29573423/toxic-money-or-paid-altruism-the-meaning-of-payments-for-identity-release-gamete-donors
#11
Leah Gilman
Public discourses commonly frame gamete, organ and other forms of bodily donation as altruistic 'gifts'. However, despite on-going debates about the ethics of payments to donors, few studies have examined the views of donors themselves regarding the meaning of payments and their compatibility (or not) with understandings of these practices as gifts. This article addresses this issue, analysing 24 in-depth interviews with UK identity-release gamete donors. It was crucial to all participants that their donation be viewed as fundamentally other-oriented, motivated by the desire to help others...
May 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29528446/characterization-of-migratory-primordial-germ-cells-in-the-aorta-gonad-mesonephros-of-a-4-5-week-old-human-embryo-a-toolbox-to-evaluate-in-vitro-early-gametogenesis
#12
Maria Gomes Fernandes, Monika Bialecka, Daniela C F Salvatori, Susana M Chuva de Sousa Lopes
STUDY QUESTION: Which set of antibodies can be used to identify migratory and early post-migratory human primordial germ cells (hPGCs)? STUDY FINDING: We validated the specificity of 33 antibodies for 31 markers, including POU5F1, NANOG, PRDM1 and TFAP2C as specific markers of hPGCs at 4.5 weeks of development of Carnegie stage (CS12-13), whereas KIT and SOX17 also marked the intra-aortic hematopoietic stem cell cluster in the aorta-gonad-mesonephros (AGM). WHAT IS KNOWN ALREADY: The dynamics of gene expression during germ cell development in mice is well characterized and this knowledge has proved crucial to allow the development of protocols for the in vitro derivation of functional gametes...
May 1, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29477167/human-pre-gastrulation-development
#13
Sissy E Wamaitha, Kathy K Niakan
Understanding the progression of early human embryonic development prior to implantation is of fundamental biological importance. Greater insights into early developmental events may lead to clinical improvements, not only via the establishment of novel stem cell models with increased potential or more physiological relevance, but also by uncovering some underlying causes of infertility, miscarriages, and developmental disorders. The majority of human embryos available for study are those donated to research once they are surplus to family building following in vitro fertilization, though in some countries it is also possible to create embryos using donated gametes...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29329390/human-oocyte-calcium-analysis-predicts-the-response-to-assisted-oocyte-activation-in-patients-experiencing-fertilization-failure-after-icsi
#14
M Ferrer-Buitrago, L Dhaenens, Y Lu, D Bonte, F Vanden Meerschaut, P De Sutter, L Leybaert, B Heindryckx
STUDY QUESTION: Can human oocyte calcium analysis predict fertilization success after assisted oocyte activation (AOA) in patients experiencing fertilization failure after ICSI? SUMMARY ANSWER: ICSI-AOA restores the fertilization rate only in patients displaying abnormal Ca2+ oscillations during human oocyte activation. WHAT IS KNOWN ALREADY: Patients capable of activating mouse oocytes and who showed abnormal Ca2+ profiles after mouse oocyte Ca2+ analysis (M-OCA), have variable responses to ICSI-AOA...
January 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29317125/intergenerational-gamete-donation-may-be-clinically-challenging-but-it-is-ethically-defensible
#15
EDITORIAL
Mark V Sauer
No abstract text is available yet for this article.
February 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29301011/should-mitochondrial-donation-be-anonymous
#16
John B Appleby
Currently in the United Kingdom, anyone donating gametes has the status of an open-identity donor. This means that, at the age of 18, persons conceived with gametes donated since April 1, 2005 have a right to access certain pieces of identifying information about their donor. However, in early 2015, the UK Parliament approved new regulations that make mitochondrial donors anonymous. Both mitochondrial donation and gamete donation are similar in the basic sense that they involve the contribution of gamete materials to create future persons...
March 13, 2018: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29213142/the-attitudes-of-ivf-patients-treated-in-the-czech-republic-towards-informing-children-born-after-gamete-donation
#17
Tatana Rumpikova, Ivana Oborna, Silvie Belaskova, Hana Konecna, David Rumpik
BACKGROUND: In recent decades gamete donation has received growing attention. Data from the Czech National Registry of Assisted Reproduction show that the number of cycles using donated oocytes has been increasing every year. According to Czech law, gamete donation is anonymous. Since 2011, some members of the Czech parliament have repeatedly made requests to revoke the anonymity but anonymity is one of the preconditions for such donation in this country. The aim of this study was to find out how the gamete recipients feel towards informing their child about the circumstances of their conception and their access to the identity of the donor...
March 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29210255/the-legalisation-of-gamete-donation-in-italy
#18
Andrea Boggio
Since 2004, the regulation of assisted reproduction in Italy has undergone substantial reform as an effect of key judicial intervention. Limitations on embryo production, screening and transfer, the prohibition against engaging in preimplantation genetic diagnosis (PGD) and embryo selection, and the ban on gamete donation have all been removed by courts. In this article, I discuss how judicial intervention has improved the ability of Italian couples to access assisted reproduction technologies (ARTs), and how the expansion of reproductive rights is, however, still incomplete...
March 2017: European Journal of Health Law
https://www.readbyqxmd.com/read/29194680/who-gets-the-gametes-an-argument-for-a-points-system-for-fertility-patients
#19
Simon Jenkins, Jonathan Ives, Sue Avery, Heather Draper
This paper argues that the convention of allocating donated gametes on a 'first come, first served' basis should be replaced with an allocation system that takes into account more morally relevant criteria than waiting time. This conclusion was developed using an empirical bioethics methodology, which involved a study of the views of 18 staff members from seven U.K. fertility clinics, and 20 academics, policy-makers, representatives of patient groups, and other relevant professionals, on the allocation of donated sperm and eggs...
January 2018: Bioethics
https://www.readbyqxmd.com/read/29142202/genomic-mosaicism-in-paternal-sperm-and-multiple-parental-tissues-in-a-dravet-syndrome-cohort
#20
Xiaoxu Yang, Aijie Liu, Xiaojing Xu, Xiaoling Yang, Qi Zeng, Adam Yongxin Ye, Zhe Yu, Sheng Wang, August Yue Huang, Xiru Wu, Qixi Wu, Liping Wei, Yuehua Zhang
Genomic mosaicism in parental gametes and peripheral tissues is an important consideration for genetic counseling. We studied a Chinese cohort affected by a severe epileptic disorder, Dravet syndrome (DS). There were 56 fathers who donated semen and 15 parents who donated multiple peripheral tissue samples. We used an ultra-sensitive quantification method, micro-droplet digital PCR (mDDPCR), to detect parental mosaicism of the proband's pathogenic mutation in SCN1A, the causal gene of DS in 112 families. Ten of the 56 paternal sperm samples were found to exhibit mosaicism of the proband's mutations, with mutant allelic fractions (MAFs) ranging from 0...
November 15, 2017: Scientific Reports
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