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https://www.readbyqxmd.com/read/30343515/variation-in-emergency-department-adherence-to-treatment-guidelines-for-inpatient-pneumonia-and-sepsis-a-retrospective-cohort-study
#1
Stacy A Trent, Zachary J Jarou, Edward P Havranek, Adit A Ginde, Jason S Haukoos
OBJECTIVES: Evidence-based clinical practice guidelines (CPGs) for the treatment of pneumonia and sepsis have existed for many years with multiple studies suggesting improved patient outcomes. Despite their importance, little is known about variation in emergency department (ED) adherence to these CPGs. Our objectives were to estimate variation in ED adherence across CPGs for pneumonia and sepsis, and identify patient, provider, and environmental factors associated with adherence. METHODS: Design: Multicenter retrospective study using standard medical record review methods...
October 21, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/30343461/genes-involved-in-mirna-biogenesis-affect-meiosis-and-fertility
#2
REVIEW
Mónica Pradillo, Juan L Santos
MicroRNAs (miRNAs) are a class of small (containing about 22 nucleotides) single-stranded non-coding RNAs that regulate gene expression at the post-transcriptional level in plants and animals, being absent from unicellular organisms. They act on diverse key physiological and cellular processes, such as development and tissue differentiation, cell identity, cell cycle progression, and programmed cell death. They are also likely to be involved in a broad spectrum of human diseases. Particularly, this review examines and summarizes work characterizing the function of miRNAs in gametogenesis and fertility...
October 20, 2018: Chromosome Research
https://www.readbyqxmd.com/read/30343337/chronic-care-management-services-for-complex-diabetes-management-a-practical-overview
#3
REVIEW
Kayla L Del Valle, Marie E McDonnell
PURPOSE OF REVIEW: Formalized chronic care management has the potential to improve the quality and cost-effectiveness of complex diabetes management in adults, but has historically not been sustainably supported by health care systems. This review discusses the application of the chronic care model in the care of complex diabetes and its translation in the current reimbursement structure designed by Centers for Medicare and Medicaid Services (CMS). RECENT FINDINGS: Following the introduction of Wagner's Chronic Care Model (CCM) in the late 1990s, evidence gathered over the past 2 decades has supported the shift in focus of health care systems from acute to chronic disease management and proactive care...
October 20, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30343022/trends-in-isolated-surgical-aortic-valve-replacement-according-to-hospital-based-transcatheter-aortic-valve-replacement-volumes
#4
Harun Kundi, Jordan B Strom, Linda R Valsdottir, Sammy Elmariah, Jeffrey J Popma, Changyu Shen, Robert W Yeh
OBJECTIVES: This study sought to evaluate the trends in isolated surgical aortic valve replacement (SAVR) procedures across hospitals with different transcatheter aortic valve replacement (TAVR) volumes among Medicare beneficiaries. BACKGROUND: The volume of TAVR has increased in the United States since its approval, now exceeding that of isolated SAVR. METHODS: Hospitalizations of adults (≥18 years) with International Classification of Diseases, Ninth Revision, Clinical Modification procedure codes for SAVR (35...
October 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30342854/what-do-young-colorectal-surgeons-value-from-their-crs-residency-training
#5
Julia T Saraidaridis, Thomas E Read, Peter W Marcello, David J Schoetz, Lawrence C Rusin, David A Kleiman, Nelya Melnitchouk, Patricia L Roberts, Elizabeth M Breen
OBJECTIVE: Colorectal surgery (CRS) training has seen many changes over the years. This study sought to identify aspects of CRS residency curriculum that were most valued by recent graduates and what changes could be made to improve training. DESIGN: Semistructured interviews were performed with board-certified colorectal surgeons 2 to 7 years removed from their CRS residency. Interview responses were qualitatively analyzed and converted to coded, categorizable data...
October 17, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/30342709/free-circulating-mirnas-measurement-in-clinical-settings-the-still-unsolved-issue-of-the-normalization
#6
Martina Faraldi, Marta Gomarasca, Giuseppe Banfi, Giovanni Lombardi
Circulating molecules that are released into the circulation in response to specific stimuli are considered potential biomarkers for physiological or pathological processes. Their effective usefulness as biomarkers resides in their stability and high availability in all the biological fluids, combined with the limited invasiveness of intervention. Among the circulating molecules, miRNAs represent a novel class of biomarkers as they possess all the required characteristics such as sensitivity, predictivity, specificity, robustness, translatability, and noninvasiveness...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/30342690/feasibility-and-usability-of-an-ontology-based-mobile-intervention-for-patients-with-hypertension
#7
Tyler S Wheeler, T Michael Vallis, Nicholas B Giacomantonio, Samina R Abidi
BACKGROUND: Lifestyle changes and the adoption of healthy behaviours are well established recommendations for the management of hypertension-a risk factor for cardiovascular and kidney disease. Mobile health interventions offer unique advantages and novel approaches to helping individuals make and maintain such behaviour changes; however, current interventions often lack theoretical and scientific grounding. OBJECTIVE: The goal of this study is to effectively model the knowledge, concepts and relationships relevant to the management of a chronic illness like hypertension, and to implement this knowledge model within a mobile self-management application that can be used by patients...
November 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/30342478/current-status-and-strategies-of-long-noncoding-rna-research-for-diabetic-cardiomyopathy
#8
REVIEW
Tarun Pant, Anuradha Dhanasekaran, Juan Fang, Xiaowen Bai, Zeljko J Bosnjak, Mingyu Liang, Zhi-Dong Ge
Long noncoding RNAs (lncRNAs) are endogenous RNA transcripts longer than 200 nucleotides which regulate epigenetically the expression of genes but do not have protein-coding potential. They are emerging as potential key regulators of diabetes mellitus and a variety of cardiovascular diseases. Diabetic cardiomyopathy (DCM) refers to diabetes mellitus-elicited structural and functional abnormalities of the myocardium, beyond that caused by ischemia or hypertension. The purpose of this review was to summarize current status of lncRNA research for DCM and discuss the challenges and possible strategies of lncRNA research for DCM...
October 20, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/30342077/successful-intracranial-delivery-of-trastuzumab-by-gene-therapy-for-treatment-of-her2-positive-breast-cancer-brain-metastases
#9
Inbal Zafir-Lavie, Shay Sherbo, Haim Goltsman, Felix Badinter, Eilam Yieni, Paula Ofek, Reem Miari, Osnat Tal, Atar Liran, Tamar Shatil, Simi Krispel, Nir Shapir, Garry A Neil, Itai Benhar, Amos Panet, Ronit Satchi Fainaro
BACKGROUND: Trastuzumab is a monoclonal antibody which demonstrates efficacy for HER2 positive breast cancer patients. Recently, an increased incidence of brain metastasis in trastuzumab-treated patients has been reported. The reason for this may be the effectiveness of systemic trastuzumab allowing patients to survive longer thus providing time for brain metastases to develop, along with the lack of penetration of systemic therapies through the blood brain barrier. In recent years, several administration routes to the brain have been evaluated...
October 17, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30342074/endothelial-dysfunction-in-diabetes-and-hypertension-role-of-micrornas-and-long-non-coding-rnas
#10
REVIEW
Hai-Na Zhang, Qiao-Qiao Xu, Abhimanyu Thakur, Martin Omondi Alfred, Manas Chakraborty, Arunima Ghosh, Xu-Ben Yu
The vascular endothelium acts as a barrier between the blood flow and the inner lining of the vessel wall, and it functions as a filtering machinery to filter out any unwanted transfer of materials from both sides (i.e. the blood and the surrounding tissues). It is evident that diseases such as diabetes, obesity, and hypertension disturb the normal endothelial functions in humans and lead to endothelial dysfunction, which may further precede to the development of atherosclerosis. Long non-coding RNAs and micro RNAs both are types of non-coding RNAs which, in the recent years, have increasingly been studied in the pathophysiology of many diseases including diabetes, obesity, cardiovascular diseases, neurological diseases, and others...
October 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/30341433/coffee-consumption-and-liver-related-hospitalizations-and-deaths-in-the-aric-study
#11
Emily A Hu, Mariana Lazo, Elizabeth Selvin, James P Hamilton, Morgan E Grams, Lyn M Steffen, Josef Coresh, Casey M Rebholz
BACKGROUND/OBJECTIVES: Coffee consumption has been found to be associated with reduced risk of chronic conditions such as liver disease. However, less is known about the association between coffee and liver-related hospitalizations and deaths. SUBJECTS/METHODS: We conducted a prospective analysis on 14,208 participants aged 45-64 years from the Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 (1987-89) and visit 3 (1993-95)...
October 19, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30341348/chromatin-accessibility-landscape-of-articular-knee-cartilage-reveals-aberrant-enhancer-regulation-in-osteoarthritis
#12
Ye Liu, Jen-Chien Chang, Chung-Chau Hon, Naoshi Fukui, Nobuho Tanaka, Zhenya Zhang, Ming Ta Michael Lee, Aki Minoda
Osteoarthritis (OA) is a common joint disorder with increasing impact in an aging society. While genetic and transcriptomic analyses have revealed some genes and non-coding loci associated to OA, the pathogenesis remains incompletely understood. Chromatin profiling, which provides insight into gene regulation, has not been reported in OA mainly due to technical difficulties. Here, we employed Assay for Transposase-Accessible Chromatin with high throughput sequencing (ATAC-seq) to map the accessible chromatin landscape in articular knee cartilage of OA patients...
October 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30341095/folic-acid-and-vitamin-b12-supplementation-and-the-risk-of-cancer-long-term-follow-up-of-the-b-vitamins-for-the-prevention-of-osteoporotic-fractures-b-proof-trial
#13
Sadaf Oliai Araghi, Jessica C Kiefte-de Jong, Suzanne C van Dijk, Karin M A Swart, Hanneke W van Laarhoven, Natasja M van Schoor, Lisette C P G M de Groot, Valery Lemmens, Bruno H Ch Stricker, André G Uitterlinden, Nathalie van der Velde
BACKGROUND: Folic acid and vitamin-B12 play key roles in one-carbon metabolism. Disruption of one-carbon metabolism may be involved in the risk of cancer. Our aim was to assess the long-term effect of supplementation with both folic acid and vitamin-B12 on the incidence of overall cancer and on colorectal cancer in the B-PROOF trial. METHODS: Long-term follow-up of B-PROOF trial participants (N=2,524), a multi-center, double-blind randomized placebo-controlled trial designed to assess the effect of 2-3 years daily supplementation with folic acid (400 µg) and vitamin-B12 (500 µg) versus placebo on fracture incidence...
October 19, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/30341064/high-affinity-interactions-and-signal-transduction-between-a%C3%AE-oligomers-and-trem2
#14
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD-associated TREM2 variants to various forms of Aβ and APOE in multiple assays. TREM2 interacts directly with various forms of Aβ, with highest affinity interactions observed between TREM2 and soluble Aβ42 oligomers. High-affinity binding of TREM2 to Aβ oligomers is characterized by very slow dissociation...
October 19, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/30340785/major-3-5-exoribonucleases-in-the-metabolism-of-coding-and-non-coding-rna
#15
Ricardo F Dos Santos, Ana P Quendera, Sofia Boavida, André F Seixas, Cecília M Arraiano, José M Andrade
3'-5' exoribonucleases are key enzymes in the degradation of superfluous or aberrant RNAs and in the maturation of precursor RNAs into their functional forms. The major bacterial 3'-5' exoribonucleases responsible for both these activities are PNPase, RNase II and RNase R. These enzymes are of ancient nature with widespread distribution. In eukaryotes, PNPase and RNase II/RNase R enzymes can be found in the cytosol and in mitochondria and chloroplasts; RNase II/RNase R-like enzymes are also found in the nucleus...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/30340500/content-validity-of-the-promis%C3%A2-pediatric-family-relationships-measure-for-children-with-chronic-illness
#16
Kathryn E Flynn, Harald Kliems, Nikita Saoji, Jacob Svenson, Elizabeth D Cox
BACKGROUND: Families play a critical role in supporting the health and well-being of children with chronic illnesses, who face a lifetime of responsibility for self-management of their condition. Our goal was to investigate whether the novel Patient-Reported Outcomes Measurement Information System® (PROMIS®) Pediatric Family Relationships measure, developed primarily within the general pediatric population, reflects the experiences of family relationships for chronically ill children and their parents...
October 19, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/30340470/a-novel-mutation-in-the-cryaa-gene-associated-with-congenital-cataract-and-microphthalmia-in-a-chinese-family
#17
Zixun Song, Nuo Si, Wei Xiao
BACKGROUND: Congenital cataract is the leading cause of blindness in children worldwide. Approximately half of all congenital cataracts have a genetic basis. Protein aggregation is the single most important factor in cataract formation. METHODS: A four-generation Chinese family diagnosed with autosomal dominant congenital cataracts and microphthalmia was recruited at the Shengjing Hospital of China Medical University. Genomic DNA was extracted from the peripheral blood of the participants...
October 19, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/30340333/hysterectomies-are-associated-with-an-increased-risk-of-depression-a-population-based-cohort-study
#18
Tomor Harnod, Weishan Chen, Jen-Hung Wang, Shinn-Zong Lin, Dah-Ching Ding
Using the National Health Insurance Research Database of Taiwan, we investigated whether undergoing a hysterectomy increases the risk of depression. A total of 7872 patients aged 30⁻49 years who underwent a hysterectomy from 2000 to 2013 were enrolled as the hysterectomy group. The comparison group was randomly selected from women who had never undergone a hysterectomy and was four times the size of the hysterectomy group. We calculated adjusted hazard ratios and 95% confidence intervals (CIs) for depression [The International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 296...
October 18, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30340328/genome-wide-transcriptomic-analysis-reveals-insights-into-the-response-to-citrus-bark-cracking-viroid-cbcvd-in-hop-humulus-lupulus-l
#19
Ajay Kumar Mishra, Atul Kumar, Deepti Mishra, Vishnu Sukumari Nath, Jernej Jakše, Tomáš Kocábek, Uday Kumar Killi, Filis Morina, Jaroslav Matoušek
Viroids are smallest known pathogen that consist of non-capsidated, single-stranded non-coding RNA replicons and they exploits host factors for their replication and propagation. The severe stunting disease caused by Citrus bark cracking viroid (CBCVd) is a serious threat, which spreads rapidly within hop gardens. In this study, we employed comprehensive transcriptome analyses to dissect host-viroid interactions and identify gene expression changes that are associated with disease development in hop. Our analysis revealed that CBCVd-infection resulted in the massive modulation of activity of over 2000 genes...
October 18, 2018: Viruses
https://www.readbyqxmd.com/read/30339847/tangeretin-an-extract-from-citrus-peels-blocks-cellular-entry-of-arenaviruses-that-cause-viral-hemorrhagic-fever
#20
Ke Tang, Shihua He, Xiaoyu Zhang, Jiamei Guo, Qing Chen, Feihu Yan, Logan Banadyga, Wenjun Zhu, Xiangguo Qiu, Ying Guo
The family Arenaviridae consists of numerous enveloped RNA viruses with ambisense coding strategies. Eight arenaviruses, including Lassa virus, are known to cause severe and fatal viral hemorrhagic fever (VHF) in humans, yet vaccines and treatments for disease caused by arenaviruses are very limited. In this study, we screened a natural product library consisting of 131 compounds and identified tangeretin, a polymethoxylated flavone widely present in citrus fruit peels, as a Lassa virus entry inhibitor that blocks viral fusion...
October 16, 2018: Antiviral Research
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