Michael Eyre, Terrence Thomas, Emanuela Ferrarin, Sonia Khamis, Sameer M Zuberi, Adrian Sie, Tamsin Newlove-Delgado, Michael Morton, Erika Molteni, Russell C Dale, Ming Lim, Margherita Nosadini
IMPORTANCE: Sydenham chorea is the most common acquired chorea of childhood worldwide; however, treatment is limited by a lack of high-quality evidence. OBJECTIVES: To evaluate historical changes in the clinical characteristics of Sydenham chorea and identify clinical and treatment factors at disease onset associated with chorea duration, relapsing disease course, and functional outcome. DATA SOURCES: The systematic search for this meta-analysis was conducted in PubMed, Embase, CINAHL, Cochrane Library, and LILACS databases and registers of clinical trials from inception to November 1, 2022 (search terms: [Sydenham OR Sydenham's OR rheumatic OR minor] AND chorea)...
April 1, 2024: JAMA Network Open