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Skin and gastrointestinal diseases

Martina Bonacini, Alessandra Soriano, Alessandro Zerbini, Eleonora Calò, Luca Cimino, Francesco Muratore, Luigi Fontana, Luca Braglia, Maria Parmeggiani, Carlo Salvarani, Stefania Croci
Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a lack of knowledge on BD pathogenesis. This study focused on circulating Natural Killer (NK), NKT and T cells evaluated as CD3neg CD56pos , CD3pos CD56pos , and CD3pos CD56neg . Peripheral blood mononuclear cells (PBMCs) were collected from 38 BD patients and 20 healthy controls (HC)...
2018: Frontiers in Immunology
Sweta U Patel, Kendra Yum, Sara Kim, Luis M Isola, Eileen Scigliano, Rita Jakubowski, Doyun Park
Graft-versus-host disease has been reported to occur rarely in syngeneic hematopoietic stem cell transplant recipients. Clinical and histological changes consistent with graft-versus-host disease have been reported to occur in this patient population. We report a case of a 46-year-old Caucasian male with diffuse large B-cell lymphoma in complete remission who underwent a syngeneic hematopoietic stem cell transplant. He was diagnosed with grade III acute skin and gastrointestinal graft-versus-host disease requiring high-dose corticosteroids and immunosuppressive therapy and resulting in a complete response...
October 14, 2018: Journal of Oncology Pharmacy Practice
E N Burns, M H Bordbari, M J Mienaltowski, V K Affolter, M V Barro, F Gianino, G Gianino, E Giulotto, T S Kalbfleisch, S A Katzman, M Lassaline, T Leeb, M Mack, E J Müller, J N MacLeod, B Ming-Whitfield, C R Alanis, T Raudsepp, E Scott, S Vig, H Zhou, J L Petersen, R R Bellone, C J Finno
The Functional Annotation of Animal Genomes (FAANG) project aims to identify genomic regulatory elements in both sexes across multiple stages of development in domesticated animals. This study represents the first stage of the FAANG project for the horse, Equus caballus. A biobank of 80 tissue samples, two cell lines and six body fluids was created from two adult Thoroughbred mares. Ante-mortem assessments included full physical examinations, lameness, ophthalmologic and neurologic evaluations. Complete blood counts and serum biochemistries were also performed...
October 11, 2018: Animal Genetics
Philip Scheltens, Merja Hallikainen, Timo Grimmer, Thomas Duning, Alida A Gouw, Charlotte E Teunissen, Alle Meije Wink, Paul Maruff, John Harrison, Caroline M van Baal, Suzanne Bruins, Inge Lues, Niels D Prins
BACKGROUND: PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects with biomarker-proven Alzheimer's disease (AD). The aim was to determine the maximal tolerated dose, target occupancy and treatment-related pharmacodynamic effects. The exploratory efficacy readouts selected were tailored to the patient population with early AD. The therapeutic approach focuses on synaptic dysfunction as captured by various measures such as electroencephalography (EEG), synaptic biomarkers and sensitive cognitive tests...
October 12, 2018: Alzheimer's Research & Therapy
Qian Kang, Jia Liu, Ying Zhao, Xin Liu, Xin-Yan Liu, Yong-Jie Wang, Nuo-Lan Mo, Qing Wu
Co-encapsulation of drugs provides a convenient means for treating different symptoms of a disease. Celastrol (Cel) shows potent anti-arthritic activity and Indomethacin (Indo) is effective in relieving inflammatory pain. Nanostructured lipid carriers loaded with Celastrol and Indomethacin (Cel-Indo-NLCs) were prepared by emulsification evaporation-solidification method, optimized by the Box-Behnken design and characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and powder X-ray diffraction analysis (PXRD)...
October 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Yoshihiro Inamoto
Chronic graft-versus-host disease (GVHD) occurs in 30-40% of patients who undergo allogeneic hematopoietic cell transplantation. The symptoms of chronic GVHD resemble those of autoimmune diseases, and many sites, including the eyes, mouth, skin, gastrointestinal tract, liver, lungs, joints, and fascia, can be affected. Severe chronic GVHD increases patients' mortality and decreases their quality of life. The 2014 National Institutes of Health (NIH) Consensus has proposed a three-step model for classification of the mechanisms of chronic GVHD: early acute inflammation, chronic inflammation with dysregulated immunity, and tissue fibrosis...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Navina Sarma, Alexander Ullrich, Hendrik Wilking, Stéphane Ghozzi, Andreas K Lindner, Christoph Weber, Alexandra Holzer, Andreas Jansen, Klaus Stark, Sabine Vygen-Bonnet
Europe received an increased number of migrants in 2015. Housing in inadequate mass accommodations (MA) made migrants prone to infectious disease outbreaks. In order to enhance awareness for infectious diseases (ID) and to detect clusters early, we developed and evaluated a syndromic surveillance system in three MA with medical centres in Berlin, Germany. Healthcare workers transferred daily data on 14 syndromes to the German public health institute (Robert Koch-Institute). Clusters of ID syndromes and single cases of outbreak-prone diseases produced a signal according to a simple aberration-detection algorithm that computes a statistical threshold above which a case count is considered unusually high...
October 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Stephen Y Liang, Nicole Messenger
Hydrologic disasters, including hurricanes, tsunamis, and severe flooding, have been associated with infectious diseases, particularly among vulnerable and displaced populations in resource-poor settings. Skin and soft tissue infections, gastrointestinal infections, respiratory infections, zoonotic infections, and vector-borne diseases each present unique threats to human health in this setting. Increased emergency physician awareness of these infectious diseases and their diagnosis and management helps optimize medical care for survivors after a hydrologic disaster and safeguard the health of disaster responders...
November 2018: Emergency Medicine Clinics of North America
Lusine Ambartsumyan, Hengqi B Zheng, Ramesh S Iyer, Jennifer Soares, Gretchen Henstorf, Anne M Stevens
OBJECTIVE: Juvenile systemic sclerosis (jSSc) is a disabling autoimmune condition that affects multiple organs in addition to skin, notably the gastrointestinal and pulmonary systems. The relationship between esophageal abnormalities and pulmonary disease in jSSc is not well understood. We describe associations between radiologic esophageal abnormalities and pulmonary function. METHODS: Clinical and radiographic data of children less than 18 years who fulfilled 2007 Pediatric Rheumatology Provisional Classification Criteria for jSSc between 1994 and 2016 were reviewed...
October 8, 2018: Arthritis Care & Research
Jaime Verdú-Amorós, Wilhelm Woessmann, Britta Maecker-Kolhoff, Ansgar Schulz, Gabriele Strauss, Gregor Bein, Holger Hackstein
BACKGROUND: Extracorporeal photopheresis (ECP) has been established to treat graft-versus-host disease. Our mini ECP technique (mini-ECP) allows for treatment of patients with GVHD and contraindications for classical ECP or low body weight. The safety and efficacy of applying ECP for the long-term treatment of chronic GVHD (cGVHD) have not been described. STUDY DESIGN AND METHODS: A retrospective analysis of mini-ECP treatments for children and adolescents with cGVHD was performed...
October 6, 2018: Transfusion
Shanthi Narla, Jonathan I Silverberg
BACKGROUND: Little is known about the risk and predictors of autoimmune diseases in children and adults. OBJECTIVE: To determine the prevalence, predictors and excess costs of autoimmune disease in AD patients. METHODS: Cross-sectional study of the 2002-2012 National Inpatient Sample, including a ∼20% sample of all US hospitalizations (n=87,053,155 adults and children). RESULTS: The prevalence [95% confidence interval {CI95}] of autoimmune disease was higher in adults (7...
October 1, 2018: Journal of the American Academy of Dermatology
Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer, Brita Fritsch
BACKGROUND: Crohn's disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been reported to a far lesser extent. The extensive detrimental impact of neurological symptoms on a patient's quality of life makes an early diagnosis and treatment particularly important. In previous case-reports, diagnosis of cerebral manifestations in CD often relied upon magnetic resonance imaging (MRI) and computed tomography (CT) alone...
October 3, 2018: BMC Neurology
G N Wali, D Halliday, J Dua, E Ieremia, T McPherson, R N Matin
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours arising in the gastrointestinal tract. Early detection, before metastasis occurs, is important as complete surgical excision achieves cure. Approximately 85% of GISTs are associated with mutations in the KIT gene, and although the majority of GISTs are sporadic, familial GISTs have been identified. Several families with multiple GIST tumours have also been described with various cutaneous findings including hyperpigmentation, multiple lentigines, vitiligo and urticaria pigmentosa...
October 2, 2018: Clinical and Experimental Dermatology
Candela Menéndez, Jonathan Fernández-Suarez, Jose A Boga Ribeiro, Mercedes Rodríguez-Pérez, Fernando Vázquez, Nieves Gonzalez-Sotorrios, Azucena Rodríguez-Guardado
INTRODUCTION: The characteristics of D. fragilis infection are described, with special focus on the clinical and epidemiological aspects. MATERIALS AND METHODS: A retrospective and descriptive study was performed, including all the patients with Dientamoeba fragilis infection who attended a specialized unit between January 2012 and December 2017. PCR was used to diagnose D. fragilis. Patients were treated with metronidazole or paromomycin and reviewed at four and eight weeks post-treatment...
September 28, 2018: Enfermedades Infecciosas y Microbiología Clínica
Joseph Meserve, Satimai Aniwan, Jenna L Koliani-Pace, Preeti Shashi, Aaron Weiss, David Faleck, Adam Winters, Shreva Chablaney, Gursimran Kochhar, Brigid S Boland, Siddharth Singh, Robert Hirten, Eugenia Shmidt, Justin G Hartke, Prianka Chilukuri, Matthew Bohm, Sashidhar Varma Sagi, Monika Fischer, Dana Lukin, David Hudesman, Shannon Chang, Youran Gao, Keith Sultan, Arun Swaminath, Nitin Gupta, Sunanda Kane, Edward V Loftus, Bo Shen, Bruce E Sands, Jean-Frederic Colombel, Corey A Siegel, William J Sandborn, Parambir S Dulai
BACKGROUND & AIMS: There are few real-world data on the safety of vedolizumab for treatment of Crohn's disease (CD) or ulcerative colitis (UC). We quantified rates and identified factors significantly associated with infectious and non-infectious adverse events in clinical practice. METHODS: We performed a retrospective review of data from a multi-center consortium database (from May 2014 through June 2017). Infectious and non-infectious adverse events were defined as those requiring antibiotics, hospitalization, vedolizumab discontinuation, or resulting in death...
September 26, 2018: Clinical Gastroenterology and Hepatology
Raymond H L Yip, Lawrence H Lee, David F Schaeffer, Basil A Horst, Hui-Min Yang
Immune checkpoint inhibitors such as programmed cell death-1 inhibitor pembrolizumab have been shown to be effective in metastatic malignancies such as advanced melanoma. Immune-related adverse effects on multiple organs have been described, such as colitis, skin rash, and hypothyroidism. We present the case of a 44-year-old man with advanced melanoma and recurrent lung metastases who developed symptoms of dyspepsia and gastroesophageal reflux disease after 1 month of therapy with pembrolizumab. Gastric biopsy showed histologic features consistent with lymphocytic gastritis, which was absent on a biopsy 2 months before initiation of therapy...
September 25, 2018: Melanoma Research
S T Jendrek, B Kahle, G Riemekasten
BACKGROUND: Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. OBJECTIVE: The different disease entities that can lead to dermal fibrosis should be differentiated. An earlier diagnosis of SSc would therefore be facilitated...
September 25, 2018: Zeitschrift Für Rheumatologie
Rosanna Satta, Giovanni M Pes, Chiara Rocchi, Maria Chiara Pes, Maria Pina Dore
BACKGROUND: Inflammatory bowel diseases (IBDs) are autoimmune disorders of the gastrointestinal tract often associated with extra‒intestinal manifestations (EIMs) including skin lesions. The intestinal microflora plays a key role in the development and course of IBD. Investigations on the association between probiotic use and skin lesions in IBD are still missing. AIM: To examine for the first time the efficacy of probiotics and the occurrence of skin lesions in patients with IBD...
September 22, 2018: Journal of Dermatological Treatment
Sunny Dhadlie, Boris Strekozov
INTRODUCTION: Cutaneous lymphomas represent a unique group of lymphomas. Cutaneous lymphomas are the second most frequent extra nodal involvement; gastrointestinal involvement being the most frequent (Malkan et al. [1]). To the best of our knowledge few cases of cutaneous relapse of Non-Hodgkin Lymphoma (NHL) have been reported where there was an absence of primary cutaneous involvement. CASE PRESENTATION: A case study of a 70-year-old woman who was referred for an excisional biopsy of a lesion on her left cheek in 2017...
September 15, 2018: International Journal of Surgery Case Reports
Kyle T Amber, Roberto Maglie, Farzan Solimani, Rüdiger Eming, Michael Hertl
Autoimmune bullous skin disorders are rare but meaningful chronic inflammatory diseases, many of which had a poor or devastating prognosis prior to the advent of immunosuppressive drugs such as systemic corticosteroids, which down-regulate the immune pathogenesis in these disorders. Glucocorticoids and adjuvant immunosuppressive drugs have been of major benefit for the fast control of most of these disorders, but their long-term use is limited by major side effects such as blood cytopenia, osteoporosis, diabetes mellitus, hypertension, and gastrointestinal ulcers...
September 20, 2018: Drugs
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