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intraplaque angiogenesis

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https://www.readbyqxmd.com/read/30244188/efficacy-of-carotid-endarterectomy-for-mild-50-symptomatic-carotid-stenosis-with-unstable-plaque
#1
Daina Kashiwazaki, Shiraishi Keitaro, Shusuke Yamamoto, Tetsuhiro Kamo, Haruto Uchino, Hisayasu Saito, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda
OBJECTIVE: Carotid endarterectomy (CEA) is known to reduce stroke risk in patients with symptomatic, moderate to severe carotid stenosis, but have no apparent impact in patients with symptomatic, mild (<50%) carotid stenosis. However, recent development of non-invasive imaging modalities has shown that a certain subgroup of them are at high risk for further ischemic events in spite of antiplatelet therapy. This study, therefore, was aimed to clarify their clinical features and to explore the impact of CEA for them...
September 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30219159/silent-information-regulator-1-negatively-regulates-atherosclerotic-angiogenesis-via-mammalian-target-of-rapamycin-complex-1-signaling-pathway
#2
Runtai Chen, Zhenchun Huang, Junyi Wang, Xiaoying Chen, Yucai Fu, Wei Wang
BACKGROUND: This study aimed to investigate the interactions between silent information regulator 1 (SIRT1) and mammalian target of rapamycin (mTOR) in intraplaque angiogenesis and their potential mechanisms through in vivo and in vitro studies. METHODS: An atherosclerosis model was established in 12 rabbits on a high-cholesterol diet. The rabbits were equally divided into 3 groups: a control group (high-lipid diet), RAP group (high-lipid diet supplemented with rapamycin) and RAP + NAM group (high-lipid diet supplemented with rapamycin and nicotinamide)...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30150423/ultrasound-microbubble-delivery-targeting-intraplaque-neovascularization-inhibits-atherosclerotic-plaque-in-an-apoe-deficient-mouse-model
#3
Hong Yuan, Haiqiang Hu, Jindong Sun, Mingjuan Shi, Huamin Yu, Cairong Li, Y U Sun, Zhijian Yang, Robert M Hoffman
BACKGROUND/AIM: Intraplaque neovascularization is often associated with plaque formation, development and instability, and clinical symptoms in atherosclerosis. The aim of the present study was to investigate a new strategy for treating athrosclerosis by ultrasound-targeted microbubble delivery (UTMD) targeting intraplaque neovascularization in an APOE-deficient mouse model of atherosclerosis. MATERIALS AND METHODS: A mouse model of atherosclerosis was induced by feeding Apoe-/- mice a hypercholesterolemic diet and was verified with hematoxylin and eosin staining and intercellular adhesion molecule 1 (ICAM-1) expression...
September 2018: In Vivo
https://www.readbyqxmd.com/read/30125282/vegf-a-vegfr-2-and-fgf-2-fgfr-1-but-not-pdgf-bb-pdgfr-%C3%AE-play-important-roles-in-promoting-immature-and-inflammatory-intraplaque-angiogenesis
#4
Yang Mao, Xiaoqiong Liu, Yu Song, Chungang Zhai, Lei Zhang
Various angiogenic factors have been shown to play important roles in intraplaque angiogenesis, while little is known about the dynamic expression change and interplay between various angiogenic factors and intraplaque angiogenesis under high cholesterol conditions. New Zealand rabbits underwent balloon injury of the abdominal artery and then were assigned to a control group (n = 15, normal chow) or high cholesterol group (n = 25, 1% high cholesterol diet). At weeks 4, 6, 8, 10, and 12 after acclimation, rabbits (high cholesterol group, n = 5; control group, n = 3) were euthanized...
2018: PloS One
https://www.readbyqxmd.com/read/30102798/blockade-of-vascular-endothelial-growth-factor-receptor-2-inhibits-intraplaque-haemorrhage-by-normalization-of-plaque-neovessels
#5
M R de Vries, L Parma, H A B Peters, A Schepers, J F Hamming, J W Jukema, M J T H Goumans, L Guo, A V Finn, R Virmani, C K Ozaki, P H A Quax
BACKGROUND: Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a natural occurring process to fulfil the increasing demand of oxygen and nourishment of the vessel wall. However, inadequate formed, immature plaque neovessels are leaky and cause intraplaque haemorrhage. OBJECTIVE: Blockade of VEGFR2 normalizes the unbridled process of plaque neovessel formation and induces maturation of nascent vessels resulting in prevention of intraplaque haemorrhage and influx of inflammatory cells into the plaque and subsequently increases plaque stability...
August 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29803682/carotid-artery-plaque-echomorphology-and-its-association-with-histopathologic-characteristics
#6
Konstantinos Spanos, Ioannis Tzorbatzoglou, Paraskevi Lazari, Dimitrios Maras, Athanasios D Giannoukas
OBJECTIVE: The aim of the study was to determine the association of ultrasonic texture features (severity of stenosis, grey scale median, plaque area, juxtaluminal black area [JBA], and discrete white areas) previously shown to be independent predictors for stroke with established histologic features of plaque instability. METHODS: A cross-sectional study was performed involving 70 patients scheduled for carotid endarterectomy. Before surgery, carotid plaque texture features were obtained with ultrasound after normalization using commercially available software (LifeQ Medical, Nicosia, Cyprus)...
May 23, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29719532/vasa-vasorum-angiogenesis-key-player-in-the-initiation-and-progression-of-atherosclerosis-and-potential-target-for-the-treatment-of-cardiovascular-disease
#7
REVIEW
Daniel G Sedding, Erin C Boyle, Jasper A F Demandt, Judith C Sluimer, Jochen Dutzmann, Axel Haverich, Johann Bauersachs
Plaque microvascularization and increased endothelial permeability are key players in the development of atherosclerosis, from the initial stages of plaque formation to the occurrence of acute cardiovascular events. First, endothelial dysfunction and increased permeability facilitate the entry of diverse inflammation-triggering molecules and particles such as low-density lipoproteins into the artery wall from the arterial lumen and vasa vasorum (VV). Recognition of entering particles by resident phagocytes in the vessel wall triggers a maladaptive inflammatory response that initiates the process of local plaque formation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29704490/mathematical-modeling-of-atherosclerotic-plaque-destabilization-role-of-neovascularization-and-intraplaque-hemorrhage
#8
Muyi Guo, Yan Cai, Xinke Yao, Zhiyong Li
Observational studies have identified angiogenesis from the adventitial vasa vasorum and intraplaque hemorrhage (IPH) as critical factors in atherosclerotic plaque progression and destabilization. Here we propose a mathematical model incorporating intraplaque neovascularization and hemodynamic calculation with plaque destabilization for the quantitative evaluation of the role of neoangiogenesis and IPH in the vulnerable atherosclerotic plaque formation. An angiogenic microvasculature is generated by two-dimensional nine-point discretization of endothelial cell proliferation and migration from the vasa vasorum...
August 7, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29669585/endoplasmic-reticulum-stress-in-perivascular-adipose-tissue-promotes-destabilization-of-atherosclerotic-plaque-by-regulating-gm-csf-paracrine
#9
Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. METHODS: We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from donor mice to carotid arteries of recipient apolipoprotein E deficient (apoE-/- ) mice after removing carotid artery collar placed for 6 weeks...
April 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29532758/platelet-derived-exosomes-affect-the-proliferation-and-migration-of-human-umbilical-vein-endothelial-cells-via-mir-126
#10
Yan Sun, Xiao-Li Liu, Dai Zhang, Fang Liu, Yu-Jing Cheng, Yue Ma, Yu-Jie Zhou, Ying-Xin Zhao
BACKGROUND: Intraplaque angiogenesis, the process of generating new blood vessels mediated by endothelial cells, contributes to plaque growth, intraplaque hemorrhage, and thromboembolic events. Platelet-derived exosomes (PLT-EXOs) affect angiogenesis in multiple ways. The ability of miR-126, one of the best-characterized miRNAs that regulates angiogenesis, carried by PLT-EXOs to influence angiogenesis via the regulation of the proliferation and migration of endothelial cells is unknown...
March 13, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29467356/endogenous-interleukin-1%C3%AE-is-implicated-in-intraplaque-hemorrhage-in-apolipoprotein-e-gene-null-mice
#11
Etsu Suzuki, Hiroyuki Imuta, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Arihiro Kiyosue, Hiroaki Nishimatsu
BACKGROUND: Intraplaque hemorrhage (IPH) has been implicated in plaque instability and rupture in atherosclerotic lesions, although the mechanisms by which IPH progresses remain largely unknown. In this study, apolipoprotein E-deficient mice with carotid artery ligation and cuff placement around the artery were used, and pro-inflammatory cytokines that are implicated in IPH were analyzed.Methods and Results:The expression of interleukin-1β (IL-1β) increased significantly following cuff placement compared with mice with carotid artery ligation alone...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29457790/cd163-macrophages-promote-angiogenesis-and-vascular-permeability-accompanied-by-inflammation-in-atherosclerosis
#12
Liang Guo, Hirokuni Akahori, Emanuel Harari, Samantha L Smith, Rohini Polavarapu, Vinit Karmali, Fumiyuki Otsuka, Rachel L Gannon, Ryan E Braumann, Megan H Dickinson, Anuj Gupta, Audrey L Jenkins, Michael J Lipinski, Johoon Kim, Peter Chhour, Paul S de Vries, Hiroyuki Jinnouchi, Robert Kutys, Hiroyoshi Mori, Matthew D Kutyna, Sho Torii, Atsushi Sakamoto, Cheol Ung Choi, Qi Cheng, Megan L Grove, Mariem A Sawan, Yin Zhang, Yihai Cao, Frank D Kolodgie, David P Cormode, Dan E Arking, Eric Boerwinkle, Alanna C Morrison, Jeanette Erdmann, Nona Sotoodehnia, Renu Virmani, Aloke V Finn
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non-foam cell antiinflammatory macrophage phenotype that was previously considered atheroprotective. Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage function with respect to angiogenesis, vascular permeability, inflammation, and plaque progression...
March 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29457787/alternative-macrophages-in-atherosclerosis-not-always-protective
#13
Benoit Pourcet, Bart Staels
Atherosclerosis is a chronic inflammatory disease of the vasculature that is initiated by cholesterol deposition into the arterial wall, which triggers the infiltration of immune and inflammatory cells, including monocytes and macrophages. As atherosclerotic plaques progress, localized hypoxia promotes compensatory angiogenesis from the vasa vasorum. Immature neovessels are prone to leakage, thus destabilizing the plaque and leading to intraplaque hemorrhage. Macrophages with different phenotypes, ranging from classical inflammatory subtypes to alternatively activated antiinflammatory macrophages, have been identified in atherosclerotic lesions...
March 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29366082/inhibition-of-vegf-receptor-signaling-attenuates-intraplaque-angiogenesis-and-plaque-destabilization-in-a-mouse-model-of-advanced-atherosclerosis
#14
Bieke Van Der Veken, Guido De Meyer, Wim Martinet
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365885/inhibition-of-glycolysis-reduces-intraplaque-angiogenesis-in-a-mouse-model-of-advanced-atherosclerosis
#15
Bieke Van Der Veken, Guido De Meyer, Wim Martinet
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29283055/the-role-of-angiogenesis-in-coronary-artery-disease-a-double-edged-sword-intraplaque-angiogenesis-in-physiopathology-and-therapeutic-angiogenesis-for-treatment
#16
Wen Wu, Xiaobo Li, Guangfeng Zuo, Jiangqin Pu, Xinlei Wu, Shaoliang Chen
Angiogenesis is described as a sprouting and growth process of new blood vessels from pre-existing vasculature. The relationship between angiogenesis and coronary artery disease (CAD) is double-sided. On one hand, angiogenesis within plaques is responsible for facilitating the growth and vulnerability of plaques by causing intraplaque hemorrhage and inflammatory cell influx, and overabundance of erythrocytes and inflammatory cells within a plaque probably causes plaque rupture, further leading to acute coronary syndrome...
2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29247718/important-signals-regulating-coronary-artery-angiogenesis
#17
REVIEW
Sara Shoeibi, Paul Mozdziak, Shabnam Mohammadi
Angiogenesis is a complex process of budding, the formation of new blood vessels from pre-existing microvessels, via migration, proliferation and survival. Vascular angiogenesis factors include different classes of molecules that have a fundamental role in blood vessel formation. Numerous inducers of angiogenesis, such as the members of the vascular endothelial growth factor (VEGF) family, basic fibroblast growth factor (bFGF), angiopoietin (Ang), hepatocyte growth factor (HGF), and hypoxia inducible factor-1 (HIF-1), have an important role in angiogenesis...
May 2018: Microvascular Research
https://www.readbyqxmd.com/read/29079346/axitinib-attenuates-intraplaque-angiogenesis-haemorrhages-and-plaque-destabilization-in-mice
#18
Bieke Van der Veken, Guido R Y De Meyer, Wim Martinet
AIM: An increased density of intraplaque (IP) microvessels in ruptured versus nonruptured human plaques suggests that IP neovascularization has a major causative effect on plaque development and instability. Possibly, vascular endothelial growth factor (VEGF) or other angiogenic factors mediate IP microvessel growth and plaque destabilization. Because apolipoprotein deficient mice with a heterozygous mutation (C1039G+/-) in the fibrillin-1 gene (ApoE-/- Fbn1C1039G+/- ) manifest substantial IP neovascularization, they represent a unique tool to further investigate angiogenesis and its role in atherosclerosis...
January 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/28798867/effect-of-intraplaque-angiogenesis-to-atherosclerotic-rupture-prone-plaque-induced-by-high-shear-stress-in-rabbit-model
#19
Juhui Qiu, Daoxi Lei, Jianjun Hu, Tieying Yin, Kang Zhang, Donghong Yu, Guixue Wang
Atherosclerotic prone-rupture plaque is mainly localized in the region of the entrance to the stenosis with high shear stress and the reasons are largely unknown. Our hypothesis is that such a distribution of cells in atherosclerotic plaque may depend on the angiogenesis. Silastic collars induced regions of high shear stress (20.68 ± 5.27 dynes/cm(2)) in the upstream flow and low shear stress (12.25 ± 1.28 dynes/cm(2)) in the downstream flow in carotid arteries. Compared with the low shear stress region, plaques in the high shear stress region showed more intraplaque haemorrhaging, less collagen and higher apoptotic rates of vascular smooth muscle cells; endothelial cells (ECs) in the high shear stress region were characterized with integrity and high endothelial nitric oxide synthase (eNOS) expression (1570...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28615707/-99m-tc-labeled-bevacizumab-for-detecting-atherosclerotic-plaque-linked-to-plaque-neovascularization-and-monitoring-antiangiogenic-effects-of-atorvastatin-treatment-in-apoe-mice
#20
Hui Tan, Jun Zhou, Xiangdong Yang, Mieradilijiang Abudupataer, Xiao Li, Yan Hu, Jie Xiao, Hongcheng Shi, Dengfeng Cheng
Atherosclerotic neovascularization plays a significant role in plaque instability as it provides additional lipids and inflammatory mediators to lesions, and resulting in intraplaque hemorrhage. Vascular endothelial growth factor-A (VEGF-A) is considered the predominant proangiogenic factor in angiogenesis. Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity. Therefore, in this study, we designed (99m)Tc-MAG3-bevacizumab as a probe, and then investigated its usefulness as a new imaging agent for the detection of plaque neovessels, while also assessing the therapeutic effect of atorvastatin treatment...
June 14, 2017: Scientific Reports
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