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https://www.readbyqxmd.com/read/30518008/-application-of-the-five-level-pediatric-emergency-triage-system-a-single-center-study
#1
H X Shi, J Z Wu, G B Chen, B Z Zhu, W Y Yan, L Chen, Y J Xiao, L Y Zhang
Objective: To assess the effectiveness in optimizing resources and shortening critical children's waiting time in pediatric emergency department (PED) with five-level pediatric emergency triage system (PETS). Methods: This retrospective study was conducted in the First Affiliated Hospital of Xiamen University after PETS was applied. The data of patients who visited the pediatric emergency department from January 2015 to December 2017 were collected and analyzed, including age, sex, diseases, visiting time, triage rate and destination...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30517993/managing-patients-with-severe-asthma-in-australia-current-challenges-with-the-existing-models-of-care
#2
Li Ping Chung, Mark Hew, Philip Bardin, Vanessa M McDonald, John W Upham
Severe asthma leads to debilitating symptoms for patients and excessive socioeconomic burden for the community. Comprehensive models of care are required to address complex issues, risk factors and comorbidities in patients with severe asthma, and to identify patients most appropriate for specialised treatments. Dedicated severe asthma services improve asthma control, reduce asthma exacerbations and hospital admissions, and improve quality of life. Currently, diverse models of care exist for managing severe asthma across Australia...
December 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/30517974/simultaneous-quantitation-of-metformin-and-dapagliflozin-in-human-plasma-by-lc-ms-ms-application-to-a-pharmacokinetic-study
#3
Priyanka A Shah, Pranav S Shrivastav, Jaivik V Shah, Archana George
A single LC-MS/MS assay is developed and validated for simultaneous determination of metformin and dapagliflozin in human plasma using ion-pair solid phase extraction. Chromatographic separation of the analytes and their internal standards was carried out on a reversed-phase ACE 5CN (150 × 4.6 mm, 5 μm) column using acetonitrile-15 mM ammonium acetate, pH 4.5 (70:30, v/v) as the mobile phase. To achieve higher sensitivity and selectivity for the analytes, mass spectrometric analysis was performed using polarity switching approach...
December 5, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/30517957/vibration-and-bubbles-a-systematic-review-of-the-effects-of-helicopter-retrieval-on-injured-divers
#4
REVIEW
Denise F Blake, Melissa Crowe, Simon J Mitchell, Peter Aitken, Neal W Pollock
INTRODUCTION: Vibration from a helicopter during aeromedical retrieval of divers may increase venous gas emboli (VGE) production, evolution or distribution, potentially worsening the patient's condition. AIM: To review the literature surrounding the helicopter transport of injured divers and establish if vibration contributes to increased VGE. METHOD: A systematic literature search of key databases was conducted to identify articles investigating vibration and bubbles during helicopter retrieval of divers...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517955/assessment-of-hyperbaric-patients-at-risk-of-malnutrition-using-the-malnutrition-screening-tool-a-pilot-study
#5
Hooi Geok See, Yan Ru Tan, Kwan Leong Au-Yeung, Michael H Bennett
BACKGROUND: Nutritional assessment and support is essential for wound management. The hyperbaric oxygen clinic is a unique outpatient service where chronically unwell patients present daily for hyperbaric oxygen treatment (HBOT) over several weeks, allowing time for effective nutritional intervention. This is the first study to examine the prevalence of those at risk of malnutrition in a cohort of hyperbaric medical patients. METHODS: A prospective study was undertaken over six months...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517953/decompression-illness-and-other-injuries-in-a-recreational-dive-charter-operation
#6
Marion Hubbard, F Michael Davis, Kate Malcolm, Scott J Mitchell
INTRODUCTION: Health and safety within the recreational diving industry are poorly described. We aimed to obtain the true prevalence of decompression illness (DCI) and other diving and non-diving injuries, including occupational injuries, in a large recreational diving charter operation. METHODS: A New Zealand recreational diving operator keeps detailed records of diving activity and event/incident reports. We extracted passenger and crew numbers, dive numbers and incident statistics from all boat trips and associated work-related injuries between 01 January 2008 and 31 December 2014...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517951/malnutrition-screening-in-outpatients-receiving-hyperbaric-oxygen-therapy-an-opportunity-for-improvement
#7
EDITORIAL
Oana A Tatucu-Babet, Emma J Ridley
Outpatients who receive hyperbaric oxygen treatment (HBOT) may represent a group at significant risk of malnutrition owing to the underlying conditions that are often treated with HBOT (e.g., non-healing diabetic wounds and radiation-induced skin injury). In this issue, See and colleagues provide new, preliminary evidence of the prevalence of malnutrition in a small group of HBOT outpatients treated in an Australian hospital, reporting that approximately one-third of patients receiving HBOT were at risk of malnutrition...
December 24, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/30517950/the-role-of-effortful-control-in-stuttering-severity-in-children-replication-study
#8
Shelly Jo Kraft, Emily Lowther, Janet Beilby
Background: In 2014, Kraft et al. assessed the temperament, home environment, and significant life events of 69 North American children who stutter to examine the combined and compounded effects of these individualized factors on mediating overt stuttering severity. The temperament domain of effortful control was singularly found to be significantly predictive of stuttering severity. Purpose: Because of the clinical significance of the initial study's findings, a replication study with a different, larger cohort of children who stutter was warranted to validate the reported outcomes...
December 5, 2018: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/30517949/over-the-counter-weight-loss-herbal-supplements-in-egypt-label-claim-microbiological-pharmaceutical-quality-and-safety-assessments
#9
Nada Ahmed, Mohamed Ismail Nounou, Alaa Abouelfetouh, Amal El-Kamel
OBJECTIVES: Nutraceuticals are advertised and sold with the label claim of being natural and safe herbal products. Due to the absence of clear regulations and guidelines for safety assessments of these products, nutraceuticals are commonly adulterated in order to increase sales. The objective of the current study was to design a comprehensive evaluation system to assess the safety, efficacy, authenticity according to label claim and pharmaceutical quality, of herbal slimming products in between 2015 and 2017...
December 5, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/30517946/digital-follow-up-and-the-perspective-of-patient-centered-care-in-oncology-what-s-the-problem
#10
REVIEW
Frank A Giordano, Grit Welzel, Victor Siefert, Lennart Jahnke, Thomas Ganslandt, Frederik Wenz, Anca-Ligia Grosu, Felix Heinemann, Nils H Nicolay
There is accumulating evidence from randomized trials suggesting that digital patient-centered care allows a more reliable detection of tumour-related symptoms and adverse events - with a direct impact on overall survival. Consequently, a variety of unsynchronized approaches were kicked off to (electronically) measure patient-reported outcomes (PROs). Despite increasing evidence that PRO data are highly relevant for patient care, the data generated in these initial projects lack standardized processing pathways in order to impact clinical routine; therefore, potential future routine PRO assessments require adequate analysis, storage and processing to allow a robust, reproducible and reliable incorporation into routine clinical decision-making...
December 5, 2018: Oncology
https://www.readbyqxmd.com/read/30517936/serum-neuroendocrine-markers-predict-therapy-outcome-of-patients-with-metastatic-castration-resistant-prostate-cancer-a-meta-analysis
#11
REVIEW
Yangzhou Liu, Shankun Zhao, Jiamin Wang, Zhiguo Zhu, Lianmin Luo, Ermao Li, Fucai Tang, Zhigang Zhao
PURPOSE: To evaluate whether serum neuroendocrine markers could effectively predict treatment outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: The PubMed, Cochrane Library and Embase databases were sought to identify eligible studies concerning serum neuroendocrine markers and the prognosis of post-treatment mCRPC from inception to April 2018. The association between serum neuroendocrine markers, that is, chromogranin A (CgA) and neurone-specific enolase (NSE), levels and the prognosis of post-treatment mCRPC were summarized using a random-effects model and hazard ratio (HR) with 95% CI Sensitivity analyses were conducted to assess potential bias...
December 5, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30517934/imaging-of-myocardial-fibrosis-and-its-functional-correlates-in-aortic-stenosis-a-review-and-clinical-potential
#12
REVIEW
Asim Katbeh, Tomas Ondrus, Emanuele Barbato, Maurizio Galderisi, Bruno Trimarco, Guy Van Camp, Marc Vanderheyden, Martin Penicka
Patients with severe aortic stenosis (AS) show progressive fibrotic changes in the myocardium, which may impair cardiac function and patient outcomes even after successful aortic valve replacement. Detection of patients who need an early operation remains a diagnostic challenge as myocardial functional changes may be subtle. In recent years, speckle tracking echocardiography (STE) and cardiac magnetic resonance mapping have been shown to provide complementary information for the assessment of left ventricular mechanics and identification of subtle damage by focal or diffuse myocardial fibrosis, respectively...
December 5, 2018: Cardiology
https://www.readbyqxmd.com/read/30517933/national-trends-and-procedural-complications-from-endomyocardial-biopsy-results-from-the-national-inpatient-sample-2007-2014
#13
Zubair Shah, Venkat Vuddanda, Aniket S Rali, Hema Pamulapati, Reza Masoomi, Kamal Gupta
AIM: The aim of this study is to report recent trends in the performance of endomyocardial biopsy (EMB) and its in-hospital complications (and their predictors) in the United States (US). METHOD: We analyzed Nationwide Inpatient Sample (NIS) database from years 2007 through 2014 to identify patients who underwent EMB. Once identified, the patients were subdivided into those with no history of heart transplant (HT) (cohort 1) and those with history of HT (cohort 2)...
December 5, 2018: Cardiology
https://www.readbyqxmd.com/read/30517924/the-chick-caudolateral-epiblast-acts-as-a-permissive-niche-for-generating-neuromesodermal-progenitor-behaviours
#14
Peter Baillie-Johnson, Octavian Voiculescu, Penny Hayward, Benjamin Steventon
Neuromesodermal progenitors (NMps) are a population of bipotent progenitors that maintain competence to generate both spinal cord and paraxial mesoderm throughout the elongation of the posterior body axis. Recent studies have generated populations of NMp-like cells in culture, which have been shown to differentiate to both neural and mesodermal cell fates when transplanted into either mouse or chick embryos. Here, we aim to compare the potential of mouse embryonic stem (ES) cell-derived progenitor populations to generate NMp behaviour against both undifferentiated and differentiated populations...
December 5, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/30517923/the-vermian-crest-angle-a-new-method-to-assess-fetal-vermis-position-within-the-posterior-fossa-using-3-dimensional-multiplanar-sonography
#15
Marialuigia Spinelli, Lavinia Di Meglio, Beatrice Mosimann, Edoardo Di Naro, Daniel Surbek, Luigi Raio
BACKGROUND: Normal morphometry of the vermis and its relation to the posterior fossa (PF) rule out most major anomalies of the cerebellum. However, accurate categorization of the position and size of the fetal vermis remains a challenge. OBJECTIVE: Our aim was to test a new method to assess the position and size of fetal vermis on 3-dimensional ultrasound (3D-US). METHODS: We measured the vermian-crest angle (VCA) in normal fetuses using multiplanar 3D-US...
December 5, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/30517920/body-fluids-in-end-stage-renal-disease-statics-and-dynamics
#16
REVIEW
Jeroen P Kooman, Frank M van der Sande
BACKGROUND: Abnormalities in fluid status in hemodialysis (HD) patients are highly prevalent and are related to adverse outcomes. SUMMARY: The inherent discontinuity of the HD procedure in combination with an often compromised cardiovascular response is a major contributor to this phenomenon. In addition, systemic inflammation and endothelial dysfunction are related to extracellular fluid overload (FO). Underlying this relation may be factors such as hypoalbuminemia and an increased capillary permeability, leading to an altered fluid distribution between the blood volume (BV) and the interstitial fluid compartments, compromising fluid removal during dialysis...
December 5, 2018: Blood Purification
https://www.readbyqxmd.com/read/30517919/a-systematic-review-and-meta-analysis-of-molecular-biomarkers-associated-with-early-neurological-deterioration-following-acute-stroke
#17
REVIEW
Alexander J Martin, Christopher I Price
BACKGROUND: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END. SUMMARY: Electronic searches from January 1990 to March 2017 identified studies reporting a blood/cerebrospinal fluid (CSF)/urine biomarker measurement within 24 h of acute stroke and at least 2 serial assessments of clinical neurological status (< 24 h and < 7 days)...
December 5, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/30517908/cortical-excitability-affects-mood-state-in-patients-with-idiopathic-generalized-epilepsies-iges
#18
Lauren B Bolden, Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer, Jerzy P Szaflarski
Previously, we demonstrated an association between cortical hyperexcitability and mood disturbance in healthy adults. Studies have documented hyperexcitability in patients with idiopathic generalized epilepsies (IGEs; long-interval intracortical inhibition [LICI]) and high prevalence of mood comorbidities. This study aimed to investigate the influences of cortical excitability and seizure control on mood state in patients with IGEs. Single and paired-pulse transcranial magnetic stimulation (TMS) was applied to 30 patients with IGEs (16 controlled IGEs [cIGEs], 14 with treatment-resistant IGEs [trIGEs]), and 22 healthy controls (HCs) to assess cortical excitability with LICI...
December 2, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30517905/rational-design-of-polymer-lipid-nanoparticles-for-docetaxel-delivery
#19
Juan M R Albano, Lígia Nunes de Morais Ribeiro, Verônica Muniz Couto, Mariana Barbosa Messias, Gustavo Henrique Rodrigues da Silva, Márcia Cristina Breitkreitz, Eneida de Paula, Monica Pickholz
In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of excipients used in the final formulations. A particular interest was put on the effects of the polymers in the final composition. In this direction, two poloxoamers -Pluronic F127 and F68- were selected. Some poloxamers are well known to be inhibitors of the P-glycoprotein efflux pump. Additionally, their poly-ethylene-oxide blocks can help them to escape the immune system, making the poloxamers appealing to be present in a nanoparticle designed for the treatment of cancer...
November 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30517900/identifying-the-controlling-mechanism-of-geogenic-origin-chromium-release-in-soils
#20
Maria A Lilli, Nikolaos P Nikolaidis, George P Karatzas, Nicolas Kalogerakis
A laboratory study was conducted to assess the mobility and mechanisms of chromium release from soils obtained from an area of wide spread geogenic contamination. The agricultural soil sample used in this study was taken from the Schimatari area in Asopos River basin in Greece. In order to refine the isolation of minerals contained in the soil, two types of separation analysis were conducted. First, a size fractionation with hydrocyclone and second, a weight fractionation with heavy liquids. The separated fractions were characterized using chemical, mineralogical and surface analysis...
November 27, 2018: Journal of Hazardous Materials
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