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JOURNAL ARTICLE
Stefanie Cavalcanti, Olga A Lopez, Simon Kung, Jennifer L Vande Voort, Kristin Somers, Mark A Frye, Balwinder Singh
No abstract text is available yet for this article.
April 10, 2024: Journal of Clinical Psychopharmacology
#2
JOURNAL ARTICLE
Ashok Seshadri, Larry Prokop, Balwinder Singh
OBJECTIVE: Intravenous (IV) racemic ketamine and intranasal (IN) esketamine have demonstrated rapid antidepressant effects in treatment-resistant depression(TRD). This systematic review aims to evaluate the efficacy and safety of ketamine and esketamine at various dosages for TRD. METHODS: We included randomized controlled trials (RCTs) with parallel group dose comparison of ketamine and esketamine for TRD. Ovid Medline, Embase, PsycINFO, Scopus and Cochrane databases were searched...
March 25, 2024: Journal of Affective Disorders
#3
REVIEW
Laura Duque, Mohammad Ghafouri, Nicolas A Nunez, Juan Pablo Ospina, Kemuel L Philbrick, John D Port, Rodolfo Savica, Larry J Prokop, Teresa A Rummans, Balwinder Singh
BACKGROUND: Catatonia is a challenging and heterogeneous neuropsychiatric syndrome of motor, affective and behavioral dysregulation which has been associated with multiple disorders such as structural brain lesions, systemic diseases, and psychiatric disorders. This systematic review summarized and compared functional neuroimaging abnormalities in catatonia associated with psychiatric and medical conditions. METHODS: Using PRISMA methods, we completed a systematic review of 6 databases from inception to February 7th, 2024 of patients with catatonia that had functional neuroimaging performed...
March 11, 2024: Journal of Psychosomatic Research
#4
JOURNAL ARTICLE
Balwinder Singh, Sagar V Parikh, Jennifer L Vande Voort, Vanessa K Pazdernik, Eric D Achtyes, Fernando S Goes, Anastasia K Yocum, Louis Nykamp, Alexis Becerra, LeAnn Smart, John F Greden, William V Bobo, Mark A Frye, Katherine E Burdick, Kelly A Ryan
This nonrandomized, multicenter, open-label clinical trial explored the impact of intravenous (IV) ketamine on cognitive function in adults (n = 74) with treatment-resistant depression (TRD). Patients received three IV ketamine infusions during the acute phase and, if remitted, four additional infusions in the continuation phase (Mayo site). Cognitive assessments using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were conducted at baseline, end of the acute phase, and end of the continuation phase (Mayo site)...
February 28, 2024: Psychiatry Research
#5
JOURNAL ARTICLE
Nicolas A Nuñez, Brandon J Coombes, Lindsay Melhuish Beaupre, Aysegul Ozerdem, Manuel Gardea Resendez, Francisco Romo-Nava, David J Bond, Marin Veldic, Balwinder Singh, Katherine M Moore, Hannah K Betcher, Simon Kung, Miguel L Prieto, Manuel Fuentes, Mete Ercis, Alessandro Miola, Jorge A Sanchez Ruiz, Gregory Jenkins, Anthony Batzler, Jonathan G Leung, Alfredo Cuellar-Barboza, Susannah J Tye, Susan L McElroy, Joanna M Biernacka, Mark A Frye
There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for the depressive phase of bipolar disorder (BD) with oftentimes, an inadequate treatment response and or clinical concern for mood destabilization. This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in BD...
February 13, 2024: Translational Psychiatry
#6
JOURNAL ARTICLE
Ankush Gupta, Balwinder Singh, Navreet Singh
No abstract text is available yet for this article.
February 2024: European Heart Journal. Case Reports
#7
REVIEW
Rakesh Kumar, Nicolas A Nuñez, Neha Joshi, Boney Joseph, Alessandra Verde, Ashok Seshadri, Alfredo B Cuellar Barboza, Larry J Prokop, Gustavo C Medeiros, Balwinder Singh
BACKGROUND: Ketamine is increasingly used for treatment-resistant depression (TRD) while its mechanism of action is still being investigated. In this systematic review, we appraise the current evidence of metabolomic biomarkers for racemic ketamine and esketamine in patients with TRD and healthy controls (HCs). METHODS: A comprehensive search of several databases (Ovid MEDLINE®, Embase, and Epub Ahead of Print) was performed from each database's inception to June 29, 2022, in any language, was conducted...
February 7, 2024: Bipolar Disorders
#8
JOURNAL ARTICLE
Manpreet Kaur, Balwinder Singh, Amritpal Kaur
The study investigated and compared physicochemical, functional, antioxidant properties, phenolic profile and Maillard reaction products (MRP) of flaxseed flour (FF) and flaxseed cake flour (FCF) upon dry-air roasting (DaR) of flaxseeds at 140, 160 and 180 °C for 5 and 10 min. This information on FF and FCF is limited and has considerable gaps. The raw FF exhibited higher fat, ash, antioxidant and functional properties while lower protein than the FCF. Upon increasing DaR conditions, the ash and protein increased in FCF and decreased in FF...
June 1, 2024: Food Chemistry
#9
JOURNAL ARTICLE
Balwinder Singh, Jennifer L Vande Voort, Vanessa Pazdernik, Mark A Frye, Simon Kung
BACKGROUND: There is an urgent need to identify interventions to reduce suicidality. We investigated the antisuicidal effects of intravenous (IV) ketamine and intranasal (IN) esketamine among patients with treatment-resistant depression (TRD) in a historical cohort study. METHODS: The Quick Inventory of Depressive Symptomatology self-report (QIDS-SR) question 12 was used to measure suicidal ideation (SI). Cox proportional hazards models were used to evaluate associations between the number of treatments to response and baseline SI (yes, Q12 > 0 versus no, Q12 = 0), adjusting for covariates and modified baseline QIDS-SR score...
January 30, 2024: Journal of Affective Disorders
#10
JOURNAL ARTICLE
Birinderjit Singh Kalyan, Balwinder Singh, Rekha Devi
There has been remarkable research carried out on Nano-electronics where Quantum dot Cellular automata emerge as the forthcoming paradigm in computing. The QCA-based circuits are used in the computational Nano hardware to present computations at ultra-high speed. A systematic approach has been utilized to design the Serial in Serial out Shift (SISO) Register using JK flip flop (JK-FF) and D flip flop (D-FF). These flip flops were initially designed with lower complexity which is the dominant factor for designing any complex sequential circuit...
February 2024: Data in Brief
#11
JOURNAL ARTICLE
Gianluca Bagnato, Egidio Imbalzano, Carmelo Ioppolo, Daniela La Rosa, Marianna Chiappalone, Alberta De Gaetano, Valeria Viapiana, Natasha Irrera, Veronica Nassisi, Maria Concetta Tringali, Emanuele Balwinder Singh, Nicola Falcomatà, Vincenzo Russo, William Neal Roberts, Pierpaolo Di Micco, Antonio Giovanni Versace
Background and Objectives: In patients with COVID-19, high-flow nasal cannula (HFNC) and continuous positive airway pressure (CPAP) are widely applied as initial treatments for moderate-to-severe acute hypoxemic respiratory failure. The aim of the study was to assess which respiratory supports improve 28-day mortality and to identify a predictive index of treatment response. Materials and Methods: This is a single-center retrospective observational study including 159 consecutive adult patients with COVID-19 and moderate-to-severe hypoxemic acute respiratory failure...
December 29, 2023: Medicina
#12
JOURNAL ARTICLE
Liliana Patarroyo-Rodriguez, Vanessa Pazdernik, Jennifer L Vande Voort, Simon Kung, Balwinder Singh
BACKGROUND: Sleep disturbances are highly prevalent in depressive episodes and are linked to higher mood severity and suicidal behaviors. Slow wave sleep (SWS) and REM sleep are compromised in depression. Current evidence suggests that rapid antidepressant effects of intravenous (IV) ketamine in patients with treatment-resistant depression (TRD) is mediated by its effects on SWS and REM sleep. Sleep phenotypes may help predict ketamine response. METHOD: In this observational study, we investigated differences in rates of response among sleep phenotypes defined by QIDS-SR in a cohort of patients with TRD (n = 52) treated with IV ketamine or intranasal (IN) esketamine...
January 8, 2024: Journal of Affective Disorders
#13
JOURNAL ARTICLE
Sagar V Parikh, Jennifer L Vande Voort, Anastasia K Yocum, Eric Achtyes, Fernando S Goes, Louis Nykamp, Balwinder Singh, Daniela Lopez-Vives, Cortney E Sera, Daniel Maixner, Vijay Tarnal, Jennifer Severe, Steven Bartek, Susannah J Tye, Jose Rico, Cynthia J Stoppel, Alexis Becerra, LeAnn Smart, Christina R Miller, Mark A Frye, John F Greden, William V Bobo
OBJECTIVE: We conducted an open-label clinical trial ("Bio-K") using IV ketamine for treatment-resistant depression to identify biomarkers linked to remission. Here, we report the clinical efficacy and side effect outcomes of Bio-K. METHODS: Across 4 US sites, 75 patients ages 18-65 with treatment-refractory unipolar or bipolar depression received 3 IV ketamine infusions over an 11-day period. Key exclusion criteria were psychotic symptoms, significant substance abuse, unstable medical conditions, and any use of cannabis...
March 1, 2024: Journal of Affective Disorders
#14
REVIEW
Nicolas A Nunez, Boney Joseph, Rakesh Kumar, Ioanna Douka, Alessandro Miola, Larry J Prokop, Brian J Mickey, Balwinder Singh
Ketamine has shown rapid antidepressant and anti-suicidal effects in treatment-resistant depression (TRD) with single and serial intravenous (IV) infusions, but the effectiveness for depressive episodes of bipolar disorder is less clear. We conducted an updated systematic review and meta-analysis to appraise the current evidence on the efficacy and tolerability of ketamine/esketamine in bipolar depression. A search was conducted to identify randomized controlled trials (RCTs) and non-randomized studies examining single or multiple infusions of ketamine or esketamine treatments...
December 2, 2023: Brain Sciences
#15
Ankush Gupta, Balwinder Singh, Navreet Singh
No abstract text is available yet for this article.
December 2023: European Heart Journal. Case Reports
#16
Boney Joseph, Nicolas A Nunez, Simon Kung, Jennifer L Vande Voort, Vanessa K Pazdernik, Kathryn M Schak, Stacey M Boehm, Brooke Carpenter, Emily K Johnson, Grigoriy Malyshev, Nathan Smits, Daniel O Adewunmi, Sarah K Brown, Balwinder Singh
In the original publication [...].
November 7, 2023: Pharmaceuticals
#17
JOURNAL ARTICLE
Ankush Gupta, Abhinav Shrivastava, Sanya Chhikara, Mamas A Mamas, Rajesh Vijayvergiya, Ajay Swamy, Nalin K Mahesh, Navreet Singh, Nitin Bajaj, Balwinder Singh, Daulat Singh Meena, Chandraket Singh
BACKGROUND: Among the two stent strategies, contemporary evidence favors double kissing crush technique (DKC) for complex unprotected distal left main bifurcation (UdLMB) lesions. However one of the major challenges to these lesions is side branch (SB) restenosis. AIMS: Our aim was to identify optical coherence tomographic (OCT) characteristics that may predict SB restenosis (SBR) after UdLMB angioplasty using DKC technique. METHODS: This was a single-center, retrospective study that included 60 patients with complex UdLMB disease, who underwent OCT-guided angioplasty using DKC technique...
November 22, 2023: Catheterization and Cardiovascular Interventions
#18
JOURNAL ARTICLE
Michael A Gargano, Nicolas Matentzoglu, Ben Coleman, Eunice B Addo-Lartey, Anna V Anagnostopoulos, Joel Anderton, Paul Avillach, Anita M Bagley, Eduard Bakštein, James P Balhoff, Gareth Baynam, Susan M Bello, Michael Berk, Holli Bertram, Somer Bishop, Hannah Blau, David F Bodenstein, Pablo Botas, Kaan Boztug, Jolana Čady, Tiffany J Callahan, Rhiannon Cameron, Seth J Carbon, Francisco Castellanos, J Harry Caufield, Lauren E Chan, Christopher G Chute, Jaime Cruz-Rojo, Noémi Dahan-Oliel, Jon R Davids, Maud de Dieuleveult, Vinicius de Souza, Bert B A de Vries, Esther de Vries, J Raymond DePaulo, Beata Derfalvi, Ferdinand Dhombres, Claudia Diaz-Byrd, Alexander J M Dingemans, Bruno Donadille, Michael Duyzend, Reem Elfeky, Shahim Essaid, Carolina Fabrizzi, Giovanna Fico, Helen V Firth, Yun Freudenberg-Hua, Janice M Fullerton, Davera L Gabriel, Kimberly Gilmour, Jessica Giordano, Fernando S Goes, Rachel Gore Moses, Ian Green, Matthias Griese, Tudor Groza, Weihong Gu, Julia Guthrie, Benjamin Gyori, Ada Hamosh, Marc Hanauer, Kateřina Hanušová, Yongqun Oliver He, Harshad Hegde, Ingo Helbig, Kateřina Holasová, Charles Tapley Hoyt, Shangzhi Huang, Eric Hurwitz, Julius O B Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, David A Koolen, Megan L Kraus, Carlo Kroll, Maaike Kusters, Markus S Ladewig, David Lagorce, Meng-Chuan Lai, Pablo Lapunzina, Bryan Laraway, David Lewis-Smith, Xiarong Li, Caterina Lucano, Marzieh Majd, Mary L Marazita, Victor Martinez-Glez, Toby H McHenry, Melvin G McInnis, Julie A McMurry, Michaela Mihulová, Caitlin E Millett, Philip B Mitchell, Veronika Moslerová, Kenji Narutomi, Shahrzad Nematollahi, Julian Nevado, Andrew A Nierenberg, Nikola Novák Čajbiková, John I Nurnberger, Soichi Ogishima, Daniel Olson, Abigail Ortiz, Harry Pachajoa, Guiomar Perez de Nanclares, Amy Peters, Tim Putman, Christina K Rapp, Ana Rath, Justin Reese, Lauren Rekerle, Angharad M Roberts, Suzy Roy, Stephan J Sanders, Catharina Schuetz, Eva C Schulte, Thomas G Schulze, Martin Schwarz, Katie Scott, Dominik Seelow, Berthold Seitz, Yiping Shen, Morgan N Similuk, Eric S Simon, Balwinder Singh, Damian Smedley, Cynthia L Smith, Jake T Smolinsky, Sarah Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, Rebecca Strawbridge, Jagadish Chandrabose Sundaramurthi, Polina Talapova, Jair A Tenorio Castano, Pavel Tesner, Rhys H Thomas, Audrey Thurm, Marek Turnovec, Marielle E van Gijn, Nicole A Vasilevsky, Markéta Vlčková, Anita Walden, Kai Wang, Ron Wapner, James S Ware, Addo A Wiafe, Samuel A Wiafe, Lisa D Wiggins, Andrew E Williams, Chen Wu, Margot J Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, Lakshmi N Yatham, Anastasia K Yocum, Allan H Young, Zafer Yüksel, Peter P Zandi, Andreas Zankl, Ignacio Zarante, Miroslav Zvolský, Sabrina Toro, Leigh C Carmody, Nomi L Harris, Monica C Munoz-Torres, Daniel Danis, Christopher J Mungall, Sebastian Köhler, Melissa A Haendel, Peter N Robinson
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English...
January 5, 2024: Nucleic Acids Research
#19
JOURNAL ARTICLE
Nicolas A Nuñez, Brandon J Coombes, Lindsay Melhuish Beaupre, Francisco Romo-Nava, Manuel Gardea-Resendez, Aysegul Ozerdem, Marin Veldic, Balwinder Singh, Jorge A Sanchez Ruiz, Alfredo Cuellar-Barboza, Jonathan G Leung, Miguel L Prieto, Susan L McElroy, Joanna M Biernacka, Mark A Frye
BACKGROUND: The purpose of this study was to review the association between the SLC6A4 5-HTTLPR polymorphism and antidepressant (AD)-associated treatment emergent mania (TEM) in bipolar disorder alongside starting a discussion on the merits of developing risk stratification models to guide when not to provide AD treatment for bipolar depression. METHODS: Studies that examined the association between clinical and genetic risk factors, specifically monoaminergic transporter genetic variation, and TEM were identified...
September 2023: Journal of Clinical Psychopharmacology
#20
JOURNAL ARTICLE
Manpreet Kaur Mann, Balwinder Singh Sooch
Food packaging reinforced with Zn-doped TiO2 nanoparticles with enhanced prerequisite film-forming and biodegradable traits was prepared to augment fresh food storage. Pure and tailored metal (Zinc, Copper, and Selenium) doped TiO2 nanoparticles were synthesized and analyzed through multiple characterization techniques (optical spectra, XRD patterns (X-Ray Diffraction), Dynamic Light Scattering, and Scanning Electron Microscopy). The synthesized nanoparticles were tested for their Minimum Inhibitory Concentrations, antimicrobial potential against common lethal food pathogens, and cytotoxicity...
September 4, 2023: Scientific Reports
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