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https://www.readbyqxmd.com/read/28650688/multidrug-resistant-enterobacteriaceae-in-lebanese-hospital-wastewater-implication-in-the-one-health-concept
#1
Ziad Daoud, Jina Farah, Elie S Salem, Khalil El Kfoury, Elias Dahdouh, Khalil Masri, Claude Afif, Roula M Abdel-Massih, Ghassan M Matar
Extended-spectrum beta-lactamases (ESBL) and carbapenemase-producing organisms pose severe problems for hospitalized patients. In the absence of efficient sanitation and sewage disposal, the risks for transmission of hospital organisms into the community are high. Our objectives were to study the occurrence and mechanisms of resistance of multidrug-resistant gram-negative bacilli in two Lebanese hospital sewage treatment plants. Wastewater samples were collected, filtered, and cultivated on MacConckey+cefotaxime agars...
June 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28648647/in-vitro-antibacterial-activity-of-fosfomycin-combined-with-other-antimicrobials-against-kpc-producing-klebsiella-pneumoniae
#2
Wei Yu, Ping Shen, Zhang Bao, Kai Zhou, Beiwen Zheng, Jinru Ji, Lihua Guo, Chen Huang, Yonghong Xiao
The increasing prevalence of KPC-producing Klebsiella pneumoniae (KPC-Kp) strains poses a serious threat to patients. Therapeutic options are limited to colistin, fosfomycin, tigecycline and selected aminoglycosides. Although the combination of fosfomycin with other antimicrobials is recommended, data regarding possible synergistic activity in vitro and in vivo appear inconsistent. Here we report that five drug combinations (fosfomycin combined with imipenem, ertapenem, tigecycline, colistin or amikacin) had a significant additive effect against 136 KPC-Kp strains in an in vitro chequerboard assay...
June 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28648624/extended-spectrum-%C3%AE-lactamases-and-plasmid-mediated-quinolone-resistance-in-enterobacterial-clinical-isolates-from-neonates-in-tunisia
#3
Karama Charfi, Raoudha Grami, Abir Ben Jeddou, Aziza Messaoudi, Yosra Mani, Olfa Bouallegue, Noureddine Boujaafar, Mahjoub Aouni, Hedi Mammeri, Wejdène Mansour
This study was conducted to investigate extended-spectrum-β-lactamase (ESBL) producing Enterobacteriaceae isolates from the Center of Maternity and Neonatology of Monastir, Tunisia. Fourty-six strains out of 283 were found to produce ESBL: Klebsiella pneumoniae (n = 37), Escherichia coli (n = 6), Enterobacter cloacae (n = 2), and Citrobacter freundi (n = 1). Genotyping analysis, using ERIC2 and RAPD, showed that strains were clonally unrelated. PCR amplification followed by sequencing revealed that all strains produced CTX-M-15...
June 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28647219/higher-mortality-of-severe-influenza-patients-with-probable-aspergillosis-than-those-with-and-without-other-coinfections
#4
Yee-Huang Ku, Khee-Siang Chan, Chun-Chieh Yang, Che-Kim Tan, Yin-Ching Chuang, Wen-Liang Yu
BACKGROUND/PURPOSE: Aspergillus-associated infection might comprise up to 23-29% of severe influenza patients from the community throughout stay in an intensive care unit (ICU). In Taiwan, cases of severe influenza with aspergillosis are increasingly reported. Therefore, we describe the relative risk of mortality among severe influenza patients with aspergillosis and other coinfections compared to severe influenza patients without Aspergillus coinfections. METHODS: We retrospectively reviewed 124 adult patients with severe influenza in a tertiary medical center in southern Taiwan from January 2015 through March 2016...
June 21, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28647122/effect-of-succinate-on-phosphate-solubilization-in-nitrogen-fixing-bacteria-harbouring-chick-pea-and-their-effect-on-plant-growth
#5
Bhagya Iyer, Mahendrapal Singh Rajput, Shalini Rajkumar
Diverse nitrogen fixing bacteria harbouring chick pea rhizosphere and root nodules were tested for multiple plant growth promoting traits like tricalcium phosphate (TCP) and rock phosphate (RP) solubilization, production of ammonia, indole 3-acetic acid, chitinase, phytase and alkaline phosphatase. Isolates belonged to diverse genus like Enterobacter, Acinetobacter, Erwinia, Pseudomonas, Rhizobium, Sinorhizobium, Ensifer, Klebsiella, etc. Most isolates solubilized TCP and RP along with the lowering of media pH, indicating acidification to be the chief mechanism behind this solubilization...
September 2017: Microbiological Research
https://www.readbyqxmd.com/read/28643488/multidrug-resistance-mechanisms-of-carbapenem-resistant-klebsiella-pneumoniae-strains-isolated-in-chongqing-china
#6
Jinrong Yan, Shuli Pu, Xiaojiong Jia, Xiuyu Xu, Shuangshuang Yang, Jing Shi, Shan Sun, Liping Zhang
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR mechanisms of CRKP and identified their clonal characteristics. METHODS: PCR and sequencing were utilized to identify antibiotic resistance determinants. Integron gene cassette arrays were determined by restriction fragment length polymorphism (RFLP) analysis...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28643188/impact-of-appropriateness-of-empiric-therapy-on-outcomes-in-community-onset-bacteremia-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-klebisella-pneumoniae-definitively-treated-with-carbapenems
#7
E-J Joo, D A Park, N R Lee, S-Y Moon, J-K Choi, J-H Ko, K R Peck
Despite a significant increase of bloodstream infection caused by extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae in the community-setting, information regarding clinical outcomes of inappropriate empiric therapy (IAT) in patients with those infections is limited. A multicenter-retrospective cohort study was conducted in four hospitals. A total of 249 adults were identified to have community-onset bacteremia caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae, and definitively treated with carbapenems...
June 23, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28642945/nonribosomal-peptide-synthetase-biosynthetic-clusters-of-eskape-pathogens
#8
REVIEW
Andrew M Gulick
Covering: up to 2017.Natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. A subset of natural products is produced by nonribosomal peptide synthetases (NRPSs), a family of large, modular enzymes that function in an assembly line fashion. Because of the pharmaceutical activity of many NRPS products, much effort has gone into the exploration of their biosynthetic pathways and the diverse products they make...
June 23, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28642142/epidemiology-and-outcomes-of-bloodstream-infections-in-177-severe-burn-patients-from-an-industrial-disaster-a-multicenter-retrospective-study
#9
Chenqi Tang, Junqiang Li, Beiming Shou, Bohan Pan, Tiansheng Chen, Yongqiang Xiao, Xiaopeng Zheng, Shichu Xiao, Qian Tan, Zhaofan Xia
OBJECTIVES: To determine the characteristics of bloodstream infections (BSIs) and to evaluate the impact of BSIs on mortality in severe burn patients. METHODS: A retrospective observational study was conducted in 20 tertiary hospitals. A total of 185 Patients who experienced a massive dust explosion in eastern China were included. RESULTS: After exclusion, 177 patients were analyzed. The median total body surface area (TBSA) burned was 95% (interquartile range [IQR], 85%-98%)...
June 19, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28642139/clinical-characteristics-and-epidemiology-of-sepsis-in-the-neonatal-intensive-care-unit-in-the-era-of-multi-drug-resistant-organisms-a-retrospective-review
#10
Dawood Yusef, Tala Shalakhti, Samah Awad, Hana'a Algharaibeh, Wasim Khasawneh
BACKGROUND: Sepsis in the neonatal intensive care unit (NICU) remains one of the most significant causes of morbidity and mortality, especially for preterm newborns. Multi-drug resistant organisms (MDROs) are emerging as important pathogens that cause neonatal sepsis in NICU. Therefore, studying the epidemiology, clinical features, and outcome caused by MDROs vs. non-MDROs, and identifying risk factors that may predispose patients to sepsis by MDROs are important. METHODS: Episodes of blood culture-proven sepsis (age: 0-90 days) in the NICU at our institution from January 2012 to December 2015 were retrospectively reviewed...
June 9, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28641915/the-antimicrobial-spectrum-of-xeroform-%C3%A2
#11
David J Barillo, Anthony R Barillo, Sarah Korn, Kan Lam, Paul S Attar
INTRODUCTION/BACKGROUND: Xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. Bismuth, similar to other metals, has antimicrobial properties. Xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. Despite this, the antimicrobial spectrum of Xeroform(®) remains largely unknown. We examined the in-vitro efficacy of Xeroform(®) against common burn pathogens using zone-of-inhibition methodology in a commercial research facility...
June 19, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28641525/1-1%C3%AA-carbonyldiimidazole-cdi-mediated-facile-synthesis-structural-characterization-antimicrobial-activity-and-in-silico-studies-of-coumarin-3-carboxamide-derivatives
#12
Uzma Salar, Khalid Mohammed Khan, Muhammad Imran Fakhri, Shafqat Hussain, Saima Tauseef, Shagufta Ameer, Abdul Wadood, Huma Khan, Shahnaz Perveen
BACKGROUND: Despite of the availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. So, identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. METHOD: To explore the antimicrobial activity of coumarin-3-carboxamides for a range of bacterial and fungal strains, twenty eight derivatives were synthesized by the reaction of coumarin-3-carboxylic acid with a variety of aniline derivatives in the presence of 1,1ꞌ-carbonyldiimidazole (CDI)...
June 22, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28640920/pathogen-specific-mortality-in-very-low-birth-weight-infants-with-primary-bloodstream-infection
#13
Brar C Piening, Christine Geffers, Petra Gastmeier, Frank Schwab
OBJECTIVE: Mortality in very low birth weight infants following microbiology confirmed primary bloodstream infections varies with the type of causative pathogen. Given evidence from other studies that infections with gram negative bacteria and fungi cause a higher case fatality risk. We tried to confirm this in a nation-wide multi-center trial. METHODS: A cohort of 55,465 very low birth weight infants from 242 neonatal departments participating in the German national neonatal infection surveillance system NEO-KISS was used to investigate differences in the case fatality risk of microbiology confirmed primary bloodstream infections according to individual pathogens...
2017: PloS One
https://www.readbyqxmd.com/read/28640352/synthesis-and-evaluation-of-arylamidine-derivatives-for-new-antimicrobial-and-cytotoxic-activities
#14
Zenaide S Monte, Amanda M Silva, Gláucia M S Lima, Teresinha G DA Silva, Karla M R Marques, Maria D Rodrigues, Emerson P S Falcão, Sebastião J Melo
A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined...
April 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28639934/first-description-of-methyltransferases-in-extensively-drug-resistant-klebsiella-pneumoniae-isolates-from-saudi-arabia
#15
Baha Abdalhamid, Nasreldin Elhadi, Samar Albunayan, Khaldoon Alsamman, Reem Aljindan
PURPOSE: The resistance determinants for carbapenems, fluoroquinolones and aminoglycosides were characterized in 16 extensively drug-resistant Klebsiella pneumoniae (XDRKPN) strains collected from Saudi hospitals during 2014. METHODOLOGY: PCR and sequencing were used to detect: blaKPC, blaNDM, blaVIM, blaIMP-1,blaOXA-48, blaCTX-M, blaTEM, blaSHV and ampC for β-lactam resistance; qnrA, qnrB, qnrS, aac(6')-Ib-cr, qepA and mutations of gyrA and parC for fluoroquinolone resistance; and aacA4, aacC2, aadA1, aphA6, armA and rmtB for aminoglycoside resistance...
June 22, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28639165/molecular-characterization-of-intestinal-carriage-of-carbapenem-resistant-enterobacteriaceae-among-inpatients-at-two-iranian-university-hospitals-first-report-of-co-production-of-bla-ndm-7-and-bla-oxa-48
#16
H Solgi, F Badmasti, Z Aminzadeh, C G Giske, M Pourahmad, F Vaziri, S A Havaei, F Shahcheraghi
Gastrointestinal colonization of carbapenem-resistant Enterobacteriaceae (CRE) could serve as a reservoir for the transmission of these pathogens in the clinical setting. The aim of this study was to investigate the intestinal carriage of CRE and to analyze risk factors for CRE carriage. Rectal swabs were collected from 95 patients at two Iranian university hospitals. CRE screening was performed using selective media (CHROMagar and MacConkey agar). Polymerase chain reaction (PCR) was used to detect carbapenemase-encoding genes...
June 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28639164/lipid-peroxidation-in-gram-negative-bacteremia-modulates-the-risk-for-septic-shock-and-infections-by-resistant-klebsiella-pneumoniae
#17
S Christodoulou, E Kyriazopoulou, M Chrysanthakopoulou, G Karlis, I Karampela, K Gkizeli, N Veliki, A Safarika, E J Giamarellos-Bourboulis, G Adamis
Controversies in outcomes with the parenteral administration of antioxidants as adjuvant therapies led to the measurement of malondialdehyde (MDA), a product of lipid peroxidation, in serum collected from 120 patients with primary Gram-negative bacteremia during the first 24 h from sepsis onset. MDA was measured by the thiobarbiturate assay, followed by high-performance liquid chromatography (HPLC) analysis. After receiver operator characteristic (ROC) curve analysis, patients were divided into those with high levels of MDA and low levels of MDA...
June 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28638594/high-burden-of-antimicrobial-resistance-among-gram-negative-bacteria-causing-healthcare-associated-infections-in-a-critical-care-unit-of-nepal
#18
Narayan Prasad Parajuli, Subhash Prasad Acharya, Shyam Kumar Mishra, Keshab Parajuli, Basista Prasad Rijal, Bharat Mani Pokhrel
BACKGROUND: Healthcare associated infections (HCAI) and antimicrobial resistance are principal threats to the patients of intensive care units and are the major determining factors for patient outcome. They are associated with increased morbidity, mortality, excess hospitalization and financial costs. The present study is an attempt to investigate the spectrum and antimicrobial resistance of bacterial isolates involved in healthcare associated infections (HCAI) in the patients of a critical care unit at a tertiary care university hospital in Kathmandu, Nepal...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28638412/molecular-identification-of-aminoglycoside-modifying-enzymes-and-plasmid-mediated-quinolone-resistance-genes-among-klebsiella-pneumoniae-clinical-isolates-recovered-from-egyptian-patients
#19
Mohamed F El-Badawy, Wael M Tawakol, Shaymaa W El-Far, Ibrahim A Maghrabi, Saleh A Al-Ghamdi, Moselhy S Mansy, Mohammed S Ashour, Mohamed M Shohayeb
Inappropriate use of antibiotics in clinical settings is thought to have led to the global emergence and spread of multidrug-resistant pathogens. The goal of this study was to investigate the prevalence of genes encoding aminoglycoside resistance and plasmid-mediated quinolone resistance among clinical isolates of Klebsiella pneumoniae. All K. pneumoniae isolates were phenotypically identified using API 20E and then confirmed genotypically through amplification of the specific K. pneumoniae phoE gene. All isolates were genotyped by the enterobacterial repetitive intergenic consensus polymerase chain reaction technique (ERIC-PCR)...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/28638248/evaluation-of-microorganisms-causing-ventilator-associated-pneumonia-in-a-pediatric-intensive-care-unit
#20
Ayse Betul Ergul, Serife Cetin, Yasemin Ay Altintop, Sefika Elmas Bozdemir, Alper Ozcan, Umit Altug, Hasan Samsa, Yasemin Altuner Torun
OBJECTIVE: The aim of this study was to identify microorganisms causing ventilator-associated pneumonia (VAP) and also study the antibiotic resistance/susceptibility. MATERIALS AND METHODS: We retrospectively assessed microorganisms isolated from patients diagnosed with VAP in a pediatric intensive care unit between January 1, 2014, and June 30, 2016. RESULTS: We included 44 patients diagnosed with VAP. The prevalence thereof was 8.6 patients per 1,000 ventilator days...
June 2017: Eurasian Journal of Medicine
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