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reticulophagy

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https://www.readbyqxmd.com/read/30051577/increased-transport-of-acetyl-coa-into-the-endoplasmic-reticulum-causes-a-progeria-like-phenotype
#1
Yajing Peng, Samantha L Shapiro, Varuna C Banduseela, Inca A Dieterich, Kyle J Hewitt, Emery H Bresnick, Guangyao Kong, Jing Zhang, Kathryn L Schueler, Mark P Keller, Alan D Attie, Timothy A Hacker, Ruth Sullivan, Elle Kielar-Grevstad, Sebastian I Arriola Apelo, Dudley W Lamming, Rozalyn M Anderson, Luigi Puglielli
The membrane transporter AT-1/SLC33A1 translocates cytosolic acetyl-CoA into the lumen of the endoplasmic reticulum (ER), participating in quality control mechanisms within the secretory pathway. Mutations and duplication events in AT-1/SLC33A1 are highly pleiotropic and have been linked to diseases such as spastic paraplegia, developmental delay, autism spectrum disorder, intellectual disability, propensity to seizures, and dysmorphism. Despite these known associations, the biology of this key transporter is only beginning to be uncovered...
October 2018: Aging Cell
https://www.readbyqxmd.com/read/30027624/chromatolysis-do-injured-axons-regenerate-poorly-when-ribonucleases-attack-rough-endoplasmic-reticulum-ribosomes-and-rna
#2
REVIEW
Lawrence David Falcon Moon
After axonal injury, chromatolysis (fragmentation of Nissl substance) can occur in the soma. Electron microscopy shows that chromatolysis involves fission of the rough endoplasmic reticulum. In CNS neurons (which do not regenerate axons back to their original targets) or in motor neurons or dorsal root ganglion neurons denied axon regeneration (e.g., by transection and ligation), chromatolysis is often accompanied by degranulation (loss of ribosomes from rough endoplasmic reticulum), disaggregation of polyribosomes and degradation of monoribosomes into dust-like particles...
July 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29916296/ccpg1-a-cargo-receptor-required-for-reticulophagy-and-endoplasmic-reticulum-proteostasis
#3
Matthew D Smith, Simon Wilkinson
The importance of selective macroautophagy/autophagy in cellular health is increasingly evident. The selective degradation of portions of the endoplasmic reticulum (ER), or reticulophagy, is an emerging example but requires further mechanistic detail and broad evidence of physiological relevance. In a recent study, we identified CCPG1, an ER-resident transmembrane protein that can bind to Atg8-family proteins and, independently and discretely, to RB1CC1/FIP200. Both of these interactions are required to facilitate CCPG1's function as a reticulophagy cargo receptor...
2018: Autophagy
https://www.readbyqxmd.com/read/29911925/ccpg1-is-a-noncanonical-autophagy-cargo-receptor-essential-for-reticulophagy-and-pancreatic-er-proteostasis
#4
Vikramjit Lahiri, Daniel J Klionsky
Reticulophagy is the conserved macroautophagic/autophagic degradation of the endoplasmic reticulum (ER) in response to ER stress or general nutrient deprivation. Sequestration of the ER by phagophores plays an important role in regulating ER size and homeostasis. In their recent work, Smith et al. have discovered that the ER-localized protein CCPG1 is a novel mammalian reticulophagy receptor that interacts with core autophagy machinery components-LC3, GABARAP and RB1CC1-and regulates reticulophagy.
2018: Autophagy
https://www.readbyqxmd.com/read/29894781/glycophagy-an-emerging-target-in-pathology
#5
REVIEW
Hong Zhao, Mingzhu Tang, Meiqing Liu, Linxi Chen
Autophagy, a highly conserved self-digestion process, is initially regarded as non-selectively sequestering and degradation cytoplasmic contents. Nowadays, many kinds of selective autophagy have been found in response to various physiological cues such as mitophagy, reticulophagy and glycophagy. Glycophagy, as a selective autophagy, plays a crucial role in maintaining glucose homeostasis in many tissues including heart, liver and skeletal muscles. Moreover, glycophagy is highly regulated by many signal pathways like the cyclic AMP protein kinase A/protein kinase A, PI3K-Akt/PKB-mTOR and Calcium...
September 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29782215/detection-of-a-vita-pamp-stings-cells-into-reticulophagy
#6
Julien Moretti, J Magarian Blander
Phagocytes cope with the threat of living bacteria via detection of vita-PAMPs, a specific class of pathogen-associated molecular patterns (PAMPs) that denotes microbial viability and trigger a commensurate innate response. Prokaryotic mRNA and cyclic-di-adenosine monophosphate (c-di-AMP) serve as vita-PAMPs for Gram-negative and Gram-positive bacteria, respectively, and elicit heightened proinflammatory responses not warranted for dead bacteria. The innate sensor TMEM173/STING detects c-di-AMP produced by internalized live Gram-positive bacteria, and quickly mobilizes interdependent pre-formed cell-autonomous responses including endoplasmic reticulum (ER) stress, MTOR inactivation, and reticulophagy...
2018: Autophagy
https://www.readbyqxmd.com/read/29367738/differential-effects-of-reticulophagy-and-mitophagy-on-nonalcoholic-fatty-liver-disease
#7
Lijun Pang, Kai Liu, Daojie Liu, Fudong Lv, Yunjin Zang, Fang Xie, Jiming Yin, Ying Shi, Yanjun Wang, Dexi Chen
Autophagy affects the pathological progression of non-alcoholic fatty liver disease (NAFLD); however, the precise role of autophagy in NAFLD remains unclear. In this study, we want to identify the role of autophagy including reticulophagy and mitophagy in NAFLD pathogenesis. When HepG2 cells were treated with 400 μM oleic acid (OA), increased reticulophagy was induced 8 h after treatment, which correlated with an anti-apoptotic response as shown by the activation of the PI3K/AKT pathway, an increase in BCL-2 expression, and the downregulation of OA-induced lipotoxicity...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#8
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B)/RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
June 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28424968/visualization-of-reticulophagy-in-living-cells-using-an-endoplasmic-reticulum-targeted-p62-mutant
#9
Liang Wang, Lei Liu, Lingsong Qin, Qingming Luo, Zhihong Zhang
Reticulophagy is a type of selective autophagy in which protein aggregate-containing and/or damaged endoplasmic reticulum (ER) fragments are engulfed for lysosomal degradation, which is important for ER homeostasis. Several chemical drugs and mutant proteins that promote protein aggregate formation within the ER lumen can efficiently induce reticulophagy in mammalian cells. However, the exact mechanism and cellular localization of reticulophagy remain unclear. In this report, we took advantage of the self-oligomerization property of p62/SQSTM1, an adaptor for selective autophagy, and developed a novel reticulophagy system based on an ER-targeted p62 mutant to investigate the process of reticulophagy in living cells...
April 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28102736/dengue-and-zika-viruses-subvert-reticulophagy-by-ns2b3-mediated-cleavage-of-fam134b
#10
Nicholas J Lennemann, Carolyn B Coyne
The endoplasmic reticulum (ER) is exploited by several diverse viruses during their infectious life cycles. Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), utilize the ER as a source of membranes to establish their replication organelles and to facilitate their assembly and eventual maturation along the secretory pathway. To maintain normal homeostasis, host cells have evolved highly efficient processes to dynamically regulate the ER, such as through reticulophagy, a selective form of autophagy that leads to ER degradation...
February 2017: Autophagy
https://www.readbyqxmd.com/read/27261778/receptor-mediated-reticulophagy-a-novel-promising-therapy-target-for-diseases
#11
Lanfang Li, Jin Xu, Linxi Chen, Zhisheng Jiang
No abstract text is available yet for this article.
August 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27089685/-research-development-of-endoplasmic-reticulophagy
#12
You Wang, Su-Hong Zhu, Xiu-Hua Liu
No abstract text is available yet for this article.
December 2015: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
https://www.readbyqxmd.com/read/26921817/ultrastructure-of-the-gut-epithelium-in-acheta-domesticus-after-long-term-exposure-to-nanodiamonds-supplied-with-food
#13
Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
The biosafety of nanoparticles and the potential toxicity of nanopollutants and/or nanowastes are all currently burning issues. The increased use of nanoparticles, including nanodiamonds (ND), entails the real risk of their penetration into food chains, which may result in the contamination of animal and, as a result, human food. Knowledge about changes in the ultrastructure of tissues in organisms that have been exposed to ND is still very limited. The aim of the study was to describe the ultrastructure of the gut epithelium in Acheta domesticus after exposure to different concentrations of ND (0, 20 or 200 μg g(-1) - control, ND20 and ND200 groups, respectively) administered with food over a five-week period...
May 2016: Arthropod Structure & Development
https://www.readbyqxmd.com/read/26566146/reticulophagy-and-nucleophagy-new-findings-and-unsolved-issues
#14
REVIEW
Hitoshi Nakatogawa, Keisuke Mochida
Autophagy targets various intracellular components ranging from proteins and nucleic acids to organelles for their degradation in lysosomes or vacuoles. In selective types of autophagy, receptor proteins play central roles in target selection. These proteins bind or localize to specific targets, and also interact with Atg8 family proteins on forming autophagosomal membranes, leading to the efficient sequestration of the targets by the membranes. Our recent study revealed that yeast cells actively degrade the endoplasmic reticulum (ER) and even part of the nucleus via selective autophagy under nitrogen-deprived conditions...
2015: Autophagy
https://www.readbyqxmd.com/read/26302411/targeting-the-er-autophagy-system-in-the-trabecular-meshwork-to-treat-glaucoma
#15
REVIEW
Andrew R Stothert, Sarah N Fontaine, Jonathan J Sabbagh, Chad A Dickey
A major drainage network involved in aqueous humor dynamics is the conventional outflow pathway, which is gated by the trabecular meshwork (TM). The TM acts as a molecular sieve, providing resistance to aqueous outflow, which is responsible for regulating intraocular pressure (IOP). If the TM is damaged, aqueous outflow is impaired, IOP increases and glaucoma can manifest. Mutations in the MYOC gene cause hereditary primary open-angle glaucoma (POAG) by promoting the abnormal amyloidosis of the myocilin protein in the endoplasmic reticulum (ER), leading to ER stress-induced TM cell death...
March 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/23052213/stress-induced-self-cannibalism-on-the-regulation-of-autophagy-by-endoplasmic-reticulum-stress
#16
REVIEW
Shane Deegan, Svetlana Saveljeva, Adrienne M Gorman, Afshin Samali
Macroautophagy (autophagy) is a cellular catabolic process which can be described as a self-cannibalism. It serves as an essential protective response during conditions of endoplasmic reticulum (ER) stress through the bulk removal and degradation of unfolded proteins and damaged organelles; in particular, mitochondria (mitophagy) and ER (reticulophagy). Autophagy is genetically regulated and the autophagic machinery facilitates removal of damaged cell components and proteins; however, if the cell stress is acute or irreversible, cell death ensues...
July 2013: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/22889744/spatiotemporal-autophagic-degradation-of-oxidatively-damaged-organelles-after-photodynamic-stress-is-amplified-by-mitochondrial-reactive-oxygen-species
#17
Noemí Rubio, Isabelle Coupienne, Emmanuel Di Valentin, Ingeborg Heirman, Johan Grooten, Jacques Piette, Patrizia Agostinis
Although reactive oxygen species (ROS) have been reported to evoke different autophagic pathways, how ROS or their secondary products modulate the selective clearance of oxidatively damaged organelles is less explored. To investigate the signaling role of ROS and the impact of their compartmentalization in autophagy pathways, we used murine fibrosarcoma L929 cells overexpressing different antioxidant enzymes targeted to the cytosol or mitochondria and subjected them to photodynamic (PD) stress with the endoplasmic reticulum (ER)-associated photosensitizer hypericin...
September 2012: Autophagy
https://www.readbyqxmd.com/read/22481944/reticulophagy-and-ribophagy-regulated-degradation-of-protein-production-factories
#18
Eduardo Cebollero, Fulvio Reggiori, Claudine Kraft
During autophagy, cytosol, protein aggregates, and organelles are sequestered into double-membrane vesicles called autophagosomes and delivered to the lysosome/vacuole for breakdown and recycling of their basic components. In all eukaryotes this pathway is important for adaptation to stress conditions such as nutrient deprivation, as well as to regulate intracellular homeostasis by adjusting organelle number and clearing damaged structures. For a long time, starvation-induced autophagy has been viewed as a nonselective transport pathway; however, recent studies have revealed that autophagy is able to selectively engulf specific structures, ranging from proteins to entire organelles...
2012: International Journal of Cell Biology
https://www.readbyqxmd.com/read/20712405/autophagosome-formation-and-molecular-mechanism-of-autophagy
#19
REVIEW
Isei Tanida
Autophagy (macroautophagy), or the degradation of large numbers of cytoplasmic components, is induced by extracellular and intracellular signals, including oxidative stress, ceramide, and endoplasmic reticulum stress. This dynamic process involves membrane formation and fusion, including autophagosome formation, autophagosome-lysosome fusion, and the degradation of intra-autophagosomal contents by lysosomal hydrolases. Autophagy is associated with tumorigenesis, neurodegenerative diseases, cardiomyopathy, Crohn's disease, fatty liver, type II diabetes, defense against intracellular pathogens, antigen presentation, and longevity...
June 2011: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/18776736/ordered-bulk-degradation-via-autophagy
#20
Jörn Dengjel, Anders Riis Kristensen, Jens S Andersen
During amino acid starvation, cells undergo macroautophagy which is regarded as an unspecific bulk degradation process. Lately, more and more organelle-specific autophagy subtypes such as reticulophagy, mitophagy and ribophagy have been described and it could be shown, depending on the experimental setup, that autophagy specifically can remove certain subcellular components. We used an unbiased quantitative proteomics approach relying on stable isotope labeling by amino acids in cell culture (SILAC) to study global protein dynamics during amino acid starvation-induced autophagy...
November 2008: Autophagy
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