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https://www.readbyqxmd.com/read/27771379/novel-highly-potent-and-in%C3%A2-vivo-active-inhibitor-of-gaba-transporter-subtype-1-with-anticonvulsant-anxiolytic-antidepressant-and-antinociceptive-properties
#1
Kinga Sałat, Adrian Podkowa, Natalia Malikowska, Felix Kern, Jörg Pabel, Ewelina Wojcieszak, Katarzyna Kulig, Klaus T Wanner, Beata Strach, Elżbieta Wyska
BACKGROUND AND PURPOSE: Since GABAergic dysfunction underlies a variety of neurological and psychiatric disorders, numerous strategies leading to the augmentation of GABAergic neurotransmission have been introduced. One of them is the inhibition of GABA reuptake from the synaptic cleft mediated by four plasma membrane GABA transporters (GAT1-4). GAT1 which is exclusively expressed in the brain is an interesting target for centrally acting drugs. In this research, pharmacological properties of a novel, highly potent and selective inhibitor of GAT1, the guvacine derivative named DDPM-2571, were assessed in vivo...
October 19, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27685776/the-false-positive-responses-of-analgesic-drugs-to-the-intradermal-serotonin-and-compound-48-80-induced-scratches-as-an-animal-model-of-itch
#2
Fatih Ilkaya, Ozgur Yesilyurt, Melik Seyrek, Ozgur Gunduz, Tayfun Ide, Ahmet Akar, Ahmet Ulugol, Hasan Guzel, Ahmet Dogrul, Durmus Ucar, Caner Gunaydin
Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27618666/high-energy-ball-milling-as-green-process-to-vitrify-tadalafil-and-improve-bioavailability
#3
Anna Krupa, Marc Descamps, Jean-Francois Willart, Beata Strach, Elżbieta Wyska, Renata Jachowicz, Florence Danède
In this study, the suitability of high-energy ball milling was invesitaged with the aim to vitrify tadalafil (TD) and improve its bioavailability. To achieve this goal, pure TD as well as binary mixtures composed of the drug and Soluplus® (SL) were co-processed by high-energy ball milling. Modulated differential scanning calorimetry (MDSC) and X-ray powder diffraction (XRD) demonstrated that after such co-processing, the crystalline form of TD was transformed into an amorphous form. The presence of a single glass transition (Tg) for all the co-milled formulations indicated that TD was dispersed into SL at the molecular level, forming amorphous molecular alloys, regardless of the drug concentration...
September 12, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/26475791/arcticiflavibacter-luteus-gen-nov-sp-nov-a-member-of-the-family-flavobacteriaceae-isolated-from-intertidal-sand
#4
Chang Liu, Xi-Ying Zhang, Xi-Ruo Wen, Mei Shi, Xiu-Lan Chen, Hai-Nan Su
A yellow-pigmented, rod-shaped, non-flagellated, aerobic and Gram-reaction-negative bacterium, designated strain SM1212T, was isolated from intertidal sand of Kongsfjorden, Svalbard. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain SM1212T constituted a distinct lineage within the family Flavobacteriaceae. It shared highest 16S rRNA gene sequence similarities with the type strains of Bizionia echini (96.0 %), Lacinutrix jangbogonensis (95.8 %) and Psychroserpens damuponensis (95...
January 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/26360606/biphasic-mo2-x-m3o8-z-domain-of-the-u-pu-o-phase-diagram
#5
Michal Strach, Renaud C Belin, Jean-Christophe Richaud, Jacques Rogez
The reduction of six mixed-oxide samples containing 14, 24, 35, 46, 54, and 62 mol % Pu was studied in situ by X-ray diffraction. The samples were first oxidized in air and subsequently reduced in a controlled atmosphere corresponding to a stoichiometric composition with an O/M = 2.00. After oxidation, we observed two structures, one cubic and one orthorhombic, MO2+x and M3O8-z. The two phases were subsequently reduced back to their stoichiometric O/M = 2.00 in a controlled atmosphere. The plutonium contents of the two resulting cubic structures differed from the initial one...
September 21, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/25892486/physicochemical-properties-and-responses-in-microcirculation-of-native-tapioca-starch-based-plasma-expander
#6
COMPARATIVE STUDY
Surapong Chatpun, Jirut Meesane, Pairaya Rujirojindakul
Plasma expanders (PEs) such as hydroxyethyl strach are widely used for volume replacement. The plantation and production of tapioca in Thailand is abundant which may provide a new source for PEs starch with novel properties. This work investigated the properties and circulatory effects of native tapioca starch-based PE (TPE). Various formulations of mixture between native tapioca starch and 0.9% sodium chloride solution were prepared and characterized in order to obtain the proper physicochemical and rheological properties...
February 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/25864807/sensitive-and-precise-hplc-method-with-back-extraction-clean-up-step-for-the-determination-of-sildenafil-in-rat-plasma-and-its-application-to-a-pharmacokinetic-study
#7
Beata Strach, Elżbieta Wyska, Krzysztof Pociecha, Anna Krupa, Renata Jachowicz
A sensitive HPLC method was developed and validated for the determination of sildenafil concentrations in rat plasma (200 μL) using a liquid-liquid extraction procedure and paroxetine as an internal standard. In order to eliminate interferences and improve the peak shape, a back-extraction into an acidic solution was utilized. Chromatographic separation was achieved on a cyanopropyl bonded-phase column with a mobile phase composed of 50 m m potassium dihydrogen phosphate buffer (pH 4.5) and acetonitrile (75:25, v/v), pumped at the flow rate of 1 mL/min...
October 2015: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/25823575/prophylactic-embolization-of-the-cystic-artery-prior-to-radioembolization-of-liver-malignancies-an-evaluation-of-necessity
#8
Maciej Powerski, Anke Busse, Max Seidensticker, Frank Fischbach, Ricarda Seidensticker, Katharina Strach, Oliver Dudeck, Jens Ricke, Maciej Pech
PURPOSE: Prior to radioembolization (RE) of hepatic tumors, many centers prophylactically occlude the cystic artery (CA) during evaluation angiography (EVA) to prevent radiation-induced cholecystitis. There is no conclusive evidence for the protective effect of CA embolization and it bears the risk of inducing ischemic cholecystitis. The aim of this study is to evaluate the justification for CA embolization by comparing clinical and morphologic imaging parameters between patients undergoing coil occlusion of the cystic artery (COCA) and those with uncoiled CA (UCCA)...
June 2015: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/25707554/human-monocyte-subsets-exhibit-divergent-angiotensin-i-converting-activity
#9
M Rutkowska-Zapała, M Suski, R Szatanek, M Lenart, K Węglarczyk, R Olszanecki, T Grodzicki, M Strach, J Gąsowski, M Siedlar
Immune cells may take part in the renin-angiotensin-aldosterone system (RAAS), which plays a pivotal role in the regulation of vascular tone and blood pressure. The aim of the study was to analyse the expression and activity of angiotensin-converting enzyme type 1 (ACE1) and ACE2 in human monocytes (MO) and their subsets. The highest relative level of ACE1-, as well as ACE2-mRNA expression, was observed in CD14(++)CD16(-) (classical) MO. Moreover, in these cells, mean level of ACE2-mRNA was almost two times higher than that of ACE1-mRNA (11...
July 2015: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/25462094/two-novel-mutations-of-the-setx-gene-and-ataxia-with-oculomotor-apraxia-type-2
#10
Joanna Pera, Sarah Lechner, Saskia Biskup, Magdalena Strach, Tomasz Grodzicki, Agnieszka Slowik
No abstract text is available yet for this article.
January 2015: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/25266688/mono-fermentation-of-chicken-manure-ammonia-inhibition-and-recirculation-of-the-digestate
#11
Hong Nie, H Fabian Jacobi, Katrin Strach, Chunming Xu, Hongjun Zhou, Jan Liebetrau
The effects of ammonia concentration on the performance and stability of mono-fermentation of chicken manure were investigated in a lab-scale continuous stirred tank reactor at 40 °C. Technical stripping was performed to remove ammonia from the liquid fraction of digestate, and the entire product was recycled to the fermenter to control ammonia concentration in the fermenter. Organic loading rate (OLR) of 5.3 gVS/(L d) was achieved with an average free ammonia nitrogen (FAN) concentration of 0.77 g/L and a specific gas yield of 0...
February 2015: Bioresource Technology
https://www.readbyqxmd.com/read/24720128/-reccurent-mycobacterial-diseases-in-patient-with-impaired-axis-il-12-inf-gamma
#12
Magdalena Strach, Piotr Nalepa, Joanna Sulicka-Grodzicka, Izabella Kierzkowska, Maciej Siedlar, Tomasz Grodzicki
Mycobacteria is a large group of pathogens that are common in environment, in soil and tap water. Although mycobacteria [non tuberculosis mycobacteria] can inhabit body surface without causing any disease in the circumstances of primary or secondary immunodeficiency can cause clinically significant organ or systemic damage. Defect of IL-12/INFgamma axis is an example of primary immunodeficiency that predispose to mycobacterial infections while protection against other microorganisms is not damaged. We present review of known defects of IL-12/IFNgamma axis and brief presentation of our own experience...
2013: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/23679763/topology-and-origin-of-effective-spin-meron-pairs-in-ferromagnetic-multilayer-elements
#13
Sebastian Wintz, Christopher Bunce, Andreas Neudert, Michael Körner, Thomas Strache, Matthias Buhl, Artur Erbe, Sibylle Gemming, Jörg Raabe, Christoph Quitmann, Jürgen Fassbender
We report on pairs of converging-diverging spin vortices in Co/Rh/NiFe trilayer disks. The lateral magnetization distribution of these effective spin merons is directly imaged by means of element-selective x-ray microscopy. By this method, both the divergence and circulation states of the individual layers are identified to be antisymmetric. Reversal measurements on corresponding continuous films reveal that biquadratic interlayer exchange coupling is the cause for the effective meron pair formation. Moreover, their three-dimensional magnetization structure is determined by micromagnetic simulations...
April 26, 2013: Physical Review Letters
https://www.readbyqxmd.com/read/23462676/percutaneous-abscess-drainage-using-near-real-time-mr-guidance-in-an-open-1-0-t-mr-scanner-proof-of-concept
#14
Christian Wybranski, Katharina Strach, Felix Krenzien, Uta Wonneberger, Jürgen Bunke, Friedrich W Röhl, Ortrud Kosiek, Jens Ricke, Frank Fischbach
OBJECTIVES: The aims of our study were (1) to assess the feasibility, effectiveness, and safety of exclusively magnetic resonance (MR)-guided freehand percutaneous abscesses drainage using a 1.0-T open MR scanner and (2) to evaluate the optimal method to visualize drainage catheters in situ. MATERIAL AND METHODS: In vitro studies in a dedicated MR gelatin phantom were performed to assess visualization of 8 different sizes of drainage catheters after instillation of sole 0...
June 2013: Investigative Radiology
https://www.readbyqxmd.com/read/23399808/magnetic-resonance-guided-freehand-radiofrequency-ablation-of-malignant-liver-lesions-a-new-simplified-and-time-efficient-approach-using-an-interactive-open-magnetic-resonance-scan-platform-and-hepatocyte-specific-contrast-agent
#15
Frank Fischbach, Katharina Lohfink, Gunnar Gaffke, Christian Wybranski, Konrad Mohnike, Uta Wonneberger, Maciej Pech, Kerstin Jungnickel, Jens Ricke, Katharina Strach
OBJECTIVES: The aims of this study were to develop magnetic resonance (MR)-guided freehand radiofrequency ablation (RFA) using a near-real-time interactive MR platform in an open 1.0-T MR scanner and to determine the feasibility and safety of this new approach in the clinical setting. METHODS: The study was performed using an open 1.0-T MR system and a low-pass filter to prevent interaction between the RFA generator and the scanner. Artifact size of the radiofrequency needle was measured in 2 perpendicular views (transversal [tra] and coronal [cor]) in vitro and in the tra orientation in vivo for diagnostic (T1 high resolution isotropic volume excitation [THRIVE]/T2 turbo spin-echo [TSE]) and near-real-time (T1 fast-field-echo [FFE]) imaging...
June 2013: Investigative Radiology
https://www.readbyqxmd.com/read/23182707/elevated-markers-of-inflammation-and-endothelial-activation-and-increased-counts-of-intermediate-monocytes-in-adult-survivors-of-childhood-acute-lymphoblastic-leukemia
#16
Joanna Sulicka, Andrzej Surdacki, Tomasz Mikołajczyk, Magdalena Strach, Barbara Gryglewska, Magdalena Ćwiklińska, Walentyna Balwierz, Tomasz Guzik, Tomasz K Grodzicki
BACKGROUND: Adult survivors of childhood malignancy are prone to accelerated atherogenesis and late cardiovascular complications. Plaque formation is initiated by recruitment of monocytes and T-cells into the intima, mediated by adhesion molecules and chemokines expressed by activated endothelial cells. AIM: To assess markers of inflammatory activity, endothelial activation as well as monocyte heterogeneity in adult survivors of childhood acute lymphoblastic leukemia (ALL) who had been treated with chemotherapy without cranial irradiation...
May 2013: Immunobiology
https://www.readbyqxmd.com/read/23129459/feasibility-of-high-dose-dobutamine-stress-ssfp-cine-mri-at-3-tesla-with-patient-adaptive-local-rf-shimming-using-dual-source-rf-transmission-initial-results
#17
COMPARATIVE STUDY
K Strach, R Clauberg, A Müller, U Wonneberger, C P Naehle, M Kouwenhoven, J Gieseke, H H Schild, D Thomas
PURPOSE: To investigate the feasibility of high-dose dobutamine stress (HDDS) imaging using SSFP sequences at 3 T employing patient-adaptive local RF-shimming using a dual-source RF transmission system. MATERIALS AND METHODS: 13 Patients underwent a HDDS protocol on a 3 T MRI scanner (Achieva 3.0T-TX, Philips Healthcare), equipped with a dual-source RF transmission system. SSFP cine sequences using patient-adaptive local RF-shimming (RF-S) were compared to cine images acquired without additional shimming...
January 2013: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/22923721/mr-guided-freehand-biopsy-of-breast-lesions-in-a-1-0-t-open-mr-imager-with-a-near-real-time-interactive-platform-preliminary-experience
#18
Frank Fischbach, Holm Eggemann, Juergen Bunke, Uta Wonneberger, Jens Ricke, Katharina Strach
PURPOSE: To identify the most appropriate magnetic resonance (MR) sequence for breast biopsy with regard to lesion visibility and artifact size and to assess feasibility and safety of this approach in a clinical setting. MATERIALS AND METHODS: MR-guided interventions were performed in an open 1.0-T MR imager between November 2009 and January 2011. The prospective clinical study was approved by the institutional review board. Written informed consent was obtained...
November 2012: Radiology
https://www.readbyqxmd.com/read/22846209/elevated-asymmetric-dimethylarginine-in-young-adult-survivors-of-childhood-acute-lymphoblastic-leukemia-a-preliminary-report
#19
Joanna Sulicka, Andrzej Surdacki, Magdalena Strach, Aleksander Kwater, Barbara Gryglewska, Magdalena Ćwiklińska, Walentyna Balwierz, Tomasz K Grodzicki
BACKGROUND: Adult survivors of childhood malignancy are predisposed to late cardiovascular (CV) complications. Our aim was to estimate plasma levels of the endogenous nitric oxide formation inhibitor asymmetric dimethylarginine (ADMA), in long-term survivors of childhood acute lymphoblastic leukemia (ALL) treated with only chemotherapy. METHODS: ADMA and its isomer symmetric dimethylarginine (SDMA) were measured in 25 former ALL patients (aged 18-28 years) who had survived without recurrent disease ≥ 5 years from completing chemotherapy without cranial irradiation, and in 20 healthy controls (aged 20-31 years)...
2012: Disease Markers
https://www.readbyqxmd.com/read/22829867/a-comparative-analysis-of-polyfunctional-t-cells-and-secreted-cytokines-induced-by-bacille-calmette-gu%C3%A3-rin-immunisation-in-children-and-adults
#20
Nicole Ritz, Madeleine Strach, Carmen Yau, Binita Dutta, Marc Tebruegge, Tom G Connell, Willem A Hanekom, Warwick J Britton, Roy Robins-Browne, Nigel Curtis
BCG vaccine is one of the most commonly-administered vaccines worldwide. Studies suggest the protective efficacy of BCG against TB is better for children than for adults. One potential explanation is that BCG induces a better protective immune response in children. Twenty six children and adults were immunised with BCG. The proportion of Th1-cytokine-producing mycobacterial-specific T cells, and the concentrations of secreted cytokines, were measured before and 10 weeks after BCG immunisation. A significant increase in the proportion of mycobacterial-specific cytokine-producing T cells was observed in both age groups...
2012: PloS One
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