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Behcet’s Disease

Maryam Sahebari, Zahra Rezaieyazdi, Mandana Khodashahi
BACKGROUND: Selenium is an essential trace element with fundamental effects on human biology. Trace elements deficiency is not an uncommon finding in autoimmune diseases. This deficiency may be a consequence of autoimmune diseases or may contribute to their etiology. With regard to evidence showing the association between selenium deficiency and generation of reactive oxygen species and subsequent inflammation, reviewing the role of selenium in collagen vascular diseases could help researchers to devise strategies for managing these diseases...
October 16, 2018: Current Rheumatology Reviews
Yung-Ray Hsu, Jerry Chien-Chieh Huang, Yong Tao, Toshikatsu Kaburaki, Christopher Seungkyu Lee, Tai-Chi Lin, Chih-Chien Hsu, Shih-Hwa Chiou, De-Kuang Hwang
Uveitis is a sight-threatening disease. Up to 35% of patients may have impaired vision. Inflammation of the uvea tissue has more than 60 etiologies. Previous reports have shown that 20-40% of uveitis cases were noninfectious. Some of them may be associated with systemic rheumatological and autoimmune diseases but some may affect the eyes only. The epidemiology and clinical situations of some specific uveitis entities vary worldwide because they are influenced by genetic, ethnic, environmental, and socioeconomic factors...
October 15, 2018: Eye
Martina Bonacini, Alessandra Soriano, Alessandro Zerbini, Eleonora Calò, Luca Cimino, Francesco Muratore, Luigi Fontana, Luca Braglia, Maria Parmeggiani, Carlo Salvarani, Stefania Croci
Behçet disease (BD) is an inflammatory systemic disease with a fluctuating course, which can affect the skin, eyes, central nervous system, musculoskeletal, gastrointestinal, and vascular systems. No laboratory tests are currently available for the diagnosis of BD and monitoring disease activity. Moreover there is a lack of knowledge on BD pathogenesis. This study focused on circulating Natural Killer (NK), NKT and T cells evaluated as CD3neg CD56pos , CD3pos CD56pos , and CD3pos CD56neg . Peripheral blood mononuclear cells (PBMCs) were collected from 38 BD patients and 20 healthy controls (HC)...
2018: Frontiers in Immunology
Majid Ahmadi, Mehdi Yousefi, Sanaz Abbaspour-Aghdam, Sanam Dolati, Leili Aghebati-Maleki, Shadi Eghbal-Fard, Alireza Khabbazi, Davood Rostamzadeh, Shahriar Alipour, Mahdi Shabani, Mohammad Nouri, Zohreh Babaloo
Impaired inflammatory immune cells have been implicated in the pathogenesis of Behcet's disease (BD). In the current study, we aimed to evaluate the frequency of T helper (Th) 17 and regulatory T (Treg) cells, cytokine secretion, the expression of transcription factors related to Th17 and Treg cells, and microRNAs (miRNAs) targeting these transcription factors in BD patients. Blood samples from 47 BD patients and 58 healthy subjects were drawn, and the peripheral blood mononuclear cells (PBMCs) were separated and isolated...
October 14, 2018: Journal of Cellular Physiology
Rawan AlTaleb, Abdulmajeed Alajlan
Pyoderma gangrenosum (PG) of the penis is a very rare entity in medicine and it can be destructive. Generally, pyoderma gangrenosum is known to be common among patients with systemic diseases such as inflammatory bowel diseases, polyarthritis, diverticulosis, paraproteinaemia, myeloma, leukaemia, active chronic hepatitis, and Behcet syndrome. Early diagnosis and administrating effective treatment can prevent permanent damage to the penis and save the patient's social life. Herein we report a delayed diagnosis of Pyoderma gangrenosum of the penis resulting in partial damage and was effectively treated with cyclosporine...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Byeongzu Ghang, Joon Bum Kim, Sung-Ho Jung, Cheol Hyun Chung, Jae Won Lee, Jong Min Song, Duk Hyun Kang, Dae Hee Kim, Jinseok Kim, Bin Yoo, Suk Jung Choo
BACKGROUND: An optimal treatment for aortic regurgitation in Behcet's disease has not been established. We investigated the effect of operative technique, prosthetic material, and immunomodulation therapy on surgical outcomes. METHODS: In this study, 23 patients with Behcet's disease surgically treated for aortic regurgitation were assessed. Significant post-operative events were defined as death, aortic valve/graft-related problem(s), infective endocarditis, disabling stroke, and aortic valve/root re-operation...
October 10, 2018: Annals of Thoracic Surgery
Mine Hayriye Sorgun, Mustafa Aykut Kural, Canan Yücesan
OBJECTIVE: Neuro-Behçet's disease (NBD) is a rare manifestation of Behçet's disease (BD) and may cause severe disability. The aim of this study was to evaluate the treatment response in patients with NBD and to investigate the parameters that may influence the prognosis of the disease in patients with severe to mild-moderate disability. METHODS: The files of 60 patients admitted to our outpatient clinic for NBD between January 2007 and June 2014 were retrospectively reviewed...
October 10, 2018: European Journal of Rheumatology
Amal A Senusi, Jie Liu, Dorian Bevec, Lesley A Bergmeier, Miles Stanford, Desmond Kidd, Ali Jawad, Steve Higgins Higgins, Farida Fortune
OBJECTIVES: Patients with Behçet's disease (BD) constantly complain of fatigue and many have problems with poor sleep. This ultimately has a major impact on all aspects of normal living. To attempt to understand this, Artificial Intelligence (AI) was used to identify potential biomarkers. These were alpha-melanocyte stimulating hormone (α-MSH), vasoactive intestinal peptide (VIP) and some inflammatory cytokines. We assessed the association of fatigue, quality of sleep and disease activity with circulating concentration of α-MSH, VIP and inflammatory cytokines...
October 5, 2018: Clinical and Experimental Rheumatology
Adiel Roitman, Ilan Ben-Zvi, Liran Mendel, Avi Livneh
OBJECTIVES: Patients, suffering from inflammatory disorders, are at an increased risk to develop cardiovascular disease (CVD). Here, we examine whether in familial Mediterranean fever (FMF), a model of inflammatory diseases, inflammation also increases the risk to develop cardiovascular (CV) disease. METHODS: To explore the role of inflammation in the occurrence of CVD in FMF, we identified all FMF patients ≤55 years old with CVD, admitted to our center over a 15-year period...
September 27, 2018: Clinical and Experimental Rheumatology
Jitender Jinagal, Aniruddha Agarwal, Avinash Negi, Gaurav Gupta, Vikas Sharma, Parul Chawla Gupta, Jagat Ram
A 19-year-old Nepalese male presented with complaints of bilateral ocular discomfort, photophobia, watering, and redness for 1 week. Visual acuity was 6/12 and 6/60 in the right and left eye, respectively. On biomicroscopic examination, presence of peripheral stromal infiltrates with conjunctival follicles was noted; infiltrates progressed to involve central cornea with further decrease in vision over next few days. After ruling out infectious keratitis, detailed systemic examination and laboratory investigations were diagnostic of neuro-Behçet's disease...
October 7, 2018: European Journal of Ophthalmology
Yung Jen Lai, Wei-Chun Chan
We report a young male patient with Behçet's disease who suffered from sight-threatening recurrences under treatment with azathioprine, cyclosporine, and prednisolone. His uveitis responded well to antitumor necrosis factor (TNF)-alpha (adalimumab) for 5 months subsequently. Severe uveitis recurred soon after discontinuation of anti-TNF alpha therapy and could not be controlled well with reinstitution of the anti-TNF alpha therapy. Interferon- α 2a (IFN- α 2a) was then given along with low-dose oral prednisone (10 mg/day), and the uveitis responded well to this therapy...
July 2018: Taiwan Journal of Ophthalmology
Ning-Yi Hsia, You-Ling Li, Chun-Ju Lin, Henry Bair, Chun-Ting Lai, Jane-Ming Lin, Wen-Lu Chen, Peng-Tai Tien, Chung-Yuan Kuo, Yi-Yu Tsai
PURPOSE: The aim of this study is to evaluate the clinical use of ultra-widefield angiography (UWFA) in uveitis. MATERIALS AND METHODS: We showed the UWFA and traditional 55° fluorescein angiography (FA) of four cases with Eales' disease, idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome, Behçet's disease, and idiopathic panuveitis in a tertiary medical center. Comparison of UWFA with traditional 55°FA in the diagnosis and management of uveitis and review of the literature is also presented...
July 2018: Taiwan Journal of Ophthalmology
Elham Shahriyari, Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Masoud Soheilian, Mehdi Yaseri, Nazanin Ebrahimi Adib
PURPOSE: To evaluate the possible association of UBASH3B gene rs4936742 (T > C) polymorphism with Behcet's disease (BD) and posterior uveitis in BD. MATERIALS AND METHODS: One hundred and thirty-one patients with BD (51 Behcet's posterior uveitis and 80 non-ocular Behcet's patients) and 61 unrelated age-matched healthy individuals as a control group without any inflammatory disease were selected. All BD cases were under follow-up and treatment in uveitis or rheumatology clinics for at least 5 years...
October 5, 2018: Current Eye Research
Yasin Sakir Goker, Sedat Yılmaz, Hasan Kızıltoprak, Kemal Tekin, Gokhan Demir
PURPOSE: To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS: FAZ parameters, flow area of choriocapillaris, and vessel density values of both superficial (SCP) and deep capillary plexuses (DCP) were measured using OCTA. RESULTS: The FAZ area in SCP, FAZ area in full retinal vasculature, and FAZ perimeter were significantly higher and foveal density-300 was significantly lower in the BD group than in the control group (p = 0...
September 27, 2018: Current Eye Research
Mohanad M Elfishawi, Fatema Elgengehy, Ghada Mossallam, Sally Elfishawi, Mostafa Alfishawy, Abdallah Gad, Imman Mokhtar
INTRODUCTION: Behçet's disease is an autoimmune disease with diverse clinical manifestations with vasculitis being the hallmark of the disease. The aim of this work is to study the genetic association between human leukocyte antigen (HLA) class-I molecules of Egyptians with Behçet's disease and the disease susceptibility and clinical patterns. METHODS: Fifty-seven patients diagnosed with Behçet's disease according to the 1990 International Study Group (ISG) criteria for Behçet's disease coming from Egyptian origin up to the third grandfather were included in the study...
September 27, 2018: Immunological Investigations
Meriam Messedi, Manel Naifar, Sahar Grayaa, Faten Frikha, Mariem Messoued, Mohamed Marouene Sethom, Moncef Feki, Naziha Kaabach, Zouheir Bahloul, Kamel Jamoussi, Fatma Ayedi
Background: Fatty Acid (FA) composition of serum has been associated with many markers of inflammation. In this study, we tried to examine plasma Saturated Fatty Acid (SFA) and Monounsaturated Fatty Acid (MUFA) composition in Behçet's Disease (BD) patients. The associations between the circulating FA levels and some markers of inflammation have also been investigated. Methods: This study is a cross-sectional one. In fact, a total of 101 BD patients and healthy controls group of 99 subjects are enrolled...
2018: Open Rheumatology Journal
MohammadMahdi Saeidinejad, Sally Kardash, Laura Connell
Current European League Against Rheumatism guidelines strongly recommend considering the use of polysaccharide pneumococcal vaccine in all patients with autoimmune inflammatory rheumatic diseases. However, a previously published case series reports of reactions to 23-valent pneumococcal polysaccharide vaccine in patients with Behcet's disease. The purpose of this report is to present a similar case of a systemic adverse reaction in a patient with Behcet's disease to 23-valent pneumococcal polysaccharide vaccine...
September 25, 2018: Scottish Medical Journal
Maria Maddalena Angioni, Matteo Piga, Fabiana Paladini, Sara Lai, Gian Luca Erre, Alberto Floris, Alberto Cauli, Maria Teresa Fiorillo, Giuseppe Passiu, Carlo Carcassi, Rosa Sorrentino, Alessandro Mathieu
BACKGROUND: Behçet's disease (BD) is a polygenic immune-mediated disorder characterized by a close association with the HLA-B*51 allele. The HLA region has a strong linkage disequilibrium (LD) and carries several genetic variants (e.g. MIC-A, TNF-α genes) identified as associated to BD because of their LD with HLA-B*51. In fact, the HLA-B*51 is inherited as part of extended HLA haplotypes which are well preserved in patients with BD. Sardinian population is highly differentiated from other Mediterranean populations because of a distinctive genetic structure with very highly preserved HLA haplotypes...
2018: PloS One
Wenjie Zheng, Xiuhua Wu, Maryam Goudarzi, Jing Shi, Wei Song, Chaoran Li, Jinjing Liu, Hua Chen, Xuan Zhang, Xiaofeng Zeng, Heng-Hong Li
BACKGROUND: The diagnosis of Behçet's disease (BD) remains challenging due to the lack of diagnostic biomarkers. This study aims to identify potential serum metabolites associated with BD and its disease activity. METHODS: Medical records and serum samples of 24 pretreated BD patients, 12 post-treated BD patients, and age-matched healthy controls (HC) were collected for metabolomics and lipidomics profiling using UPLC-QTOF-MS and UPLC-QTOF-MSE approaches. Additionally, serum samples from an independent cohort of BD patients, disease controls including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Takayasu's arteritis (TA), Crohn's disease (CD) patients, and HC were collected for further validation of two potential biomarkers using UPLC-QTOFMS analysis...
September 24, 2018: Arthritis Research & Therapy
Xiaoying Wang, Keye Xu, Sisi Chen, Yan Li, Mingcai Li
Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 can join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated protein kinases. Almost all reports showed that IL-37 has remarkable anti-inflammatory activity. IL-37 plays an important role in a variety of inflammatory and autoimmune diseases, as well...
September 2018: Iranian Journal of Immunology: IJI
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