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Behcet’s Disease

Yanxia Ding, Chaoran Li, Jinjing Liu, Xin Yu, Yining Wang, Jing Shi, Lu Li, Jiaxin Zhou, Li Wang, Hua Chen, Yan Zhao, Wenjie Zheng
No abstract text is available yet for this article.
August 10, 2018: Rheumatology
Jianfei Cai, Yinjia Zhang, Jun Zou, Yan Shen, Dan Luo, Huafang Bao, Yong Chen, Jingfen Ye, Jian-Long Guan
OBJECTIVE: This study aimed to investigate the correlation of serum uric acid (SUA) with risk and dilatation diameter of ascending aortic dilatation (AAD) in Behçet's disease (BD) patients. METHODS: Seventeen BD patients complicated with AAD and 20 BD patients without AAD were consecutively enrolled and categorized into AAD group and control group, respectively. Ascending aortic dilatation was determined by two-dimensional doppler echocardiographic examination, and AAD was defined as a diameter of ascending aorta ≥3...
August 12, 2018: Journal of Clinical Laboratory Analysis
Sebastián Andrés Muñoz, Alberto Omar Orden, Alex Kostianovsky, Cecilia N Pisoni, Marina Scolnik, Aurelia Luissi, Yanina Bottinelli, Gustavo Vijoditz, Mercedes Garcia, Claudia Pena, Mariana Pera, Oscar Rillo, Teresita Alvarellos, Luciana M Más, Arturo Luis Trunzo, Alberto Allievi
OBJECTIVE: To assess the association between the HLA-B*51 allele and Behçet Disease (BD) in Argentinean patients. METHODS: We enrolled 34 consecutive Argentinean patients with definitive diagnosis of BD between October 2016 and March 2017. None of the patients had the HLA-B*51 allele determined at study entry. Unrelated controls (n=240) were randomly obtained from the national cadaveric donor database. Demographic and clinical features of the patients were recorded by attending physicians through a questionnaire...
August 6, 2018: Reumatología Clinica
Suh Min Kim, In Mok Jung
PURPOSE: Arterial involvement of Behcet disease is often found in the form of a rapidly expanding aneurysm. We report a case of successful treatment of a ruptured popliteal artery aneurysm with a stent-graft insertion. CASE REPORT: A 55-year-old male patient was admitted because of pain and swelling in the right leg that had persisted for 15 days. Computed tomography (CT) angiographyshowed a contained rupture of a large right popliteal artery aneurysm. Laboratory tests showed elevated erythrocyte sedimentation rate (ESR) and C-reactive protein level...
August 6, 2018: Annals of Vascular Surgery
Yoo Ri Chung, Eun Hyung Cho, Seran Jang, Seung Yeop Lee, Eun So Lee, Kihwang Lee
PURPOSE: To investigate whether subfoveal choroidal thickness, measured using enhanced depth imaging optical coherence tomography (EDI-OCT), is an indicator of subclinical ocular or systemic inflammation in eyes with Behçet disease (BD) without active ocular inflammation. METHODS: A retrospective analysis was used to examine clinical features of non-uveitic patients with BD (NUBD group), patients with a previous history of Behçet uveitis in an inactive state (IUBD group), and healthy controls were evaluated from October 2014 to September 2015...
August 2018: Korean Journal of Ophthalmology: KJO
Satoko Yamaguchi, Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai, Junji Umeno, Motohiro Esaki, Takayuki Matsumoto
Background/Aims: We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene ( SLCO2A1 ) as causative variants of chronic enteropathy associated with SLCO2A1 (CEAS). The aim of this study was to evaluate SLCO2A1 protein expression in the intestinal tissues of patients with CEAS, intestinal Behçet's disease (BD), simple ulcer (SU), and Crohn's disease (CD). Methods: Immunohistochemical staining using a polyclonal anti-SLCO2A1 antibody was performed on the resected intestinal specimens from 13 cases of CD, 9 cases of intestinal BD/SU, and 3 cases of CEAS...
July 2018: Intestinal Research
Elif Peker, Ayşe Erden, İlhan Erden, Nurşen Düzgün
OBJECTIVE: The purposes of this study were to discern imaging findings that distinguish Behçet disease from small-bowel Crohn disease, to find initial performance estimates for these findings, and to evaluate the diagnostic value of MR enterography (MRE) for detecting intestinal Behçet disease. MATERIALS AND METHODS: The MRE examinations of 30 consecutively registered patients with established intestinal Behçet disease were reviewed by two blinded readers. The frequencies of MRE findings were compared with those obtained for 30 control subjects with small-bowel Crohn disease who were matched for sex and age...
August 7, 2018: AJR. American Journal of Roentgenology
Jurgen Sota, Antonio Vitale, Donato Rigante, Ida Orlando, Orso Maria Lucherini, Antonella Simpatico, Giuseppe Lopalco, Rossella Franceschini, Mauro Galeazzi, Bruno Frediani, Claudia Fabiani, Gian Marco Tosi, Luca Cantarini
BACKGROUND: Behçet's disease (BD) is an inflammatory disorder potentially leading to life- and sight-threatening complications. No laboratory marker correlating with disease activity or predicting the occurrence of disease manifestations is currently available. OBJECTIVES: To determine an association between serum amyloid-A (SAA) levels and disease activity via the BD Current Activity Form (BDCAF), to evaluate disease activity in relation to different SAA thresholds, to examine the association between single organ involvement and the overall major organ involvement with different SAA thresholds, and to assess the influence of biologic therapy on SAA levels...
August 2018: Israel Medical Association Journal: IMAJ
David B Sachar
PURPOSE OF REVIEW: Not all injuries of the terminal ileum are Crohn's disease. It is the purpose of this review to consider the differential diagnosis of other acute and chronic ileal lesions. RECENT FINDINGS: The recognition of a granulomatous disease of the terminal ileum, distinct from tuberculosis, dates back over 85 years and perhaps much farther, but over the past decades, many other clinical pathologic entities have been described that are neither tuberculosis nor Crohn's eponymous regional enteritis...
August 6, 2018: Current Gastroenterology Reports
Zi Ye, Ni Zhang, Chunyan Wu, Xinyuan Zhang, Qingfeng Wang, Xinyue Huang, Liping Du, Qingfeng Cao, Jihong Tang, Chunjiang Zhou, Shengping Hou, Yue He, Qian Xu, Xiao Xiong, Aize Kijlstra, Nan Qin, Peizeng Yang
BACKGROUND: Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory disease that can lead to irreversible blindness. Microbial agents have been considered to contribute to the pathogenesis of this disease, but the underlying mechanisms remain unclear. In this study, we investigated the association of gut microbiome composition with BD as well as its possible roles in the development of this disease. METHODS: Fecal and saliva samples were collected from 32 active BD patients and 74 healthy controls...
August 4, 2018: Microbiome
Shahriar Alipour, Ebrahim Sakhinia, Alireza Khabbazi, Nasser Samadi, Zohreh Babaloo, Mahdi Azad, Somayeh Abolhasani, Jafar Farhadi, Golamreza Jadideslam, Neda Roshanravan, Mohammad Nouri
BACKGROUND: IL-6 mRNA expression is significantly high in many autoimmune diseases such as Behçet's disease; this is often related with more aggressive phenotypes. Nevertheless, the essential molecular process for its high expression has not been completely realized. The aim of this study was undertaken to estimate the gene copy number variation and promoter methylation to IL-6's high expression. METHODS: This study was performed on 51 patients and 61 healthy controls...
July 31, 2018: Reumatología Clinica
Alexandru Oanță, Veronica Iliescu, Smaranda Țărean
Half and half nails or Lindsay's nails were first mentioned by Bean (1) in 1964 and later described by Lindsay (2) in 1967 in patients with chronic kidney disease. They can occur in various diseases but also in healthy individuals. A 57-year-old patient with no significant pathological personal history consulted us for discoloration of all his nails on the fingers (Figure 1) and toes (Figure 2). The change in color occurred 17 years ago and had persisted since. The patient had no significant family history and denied a longer period of consumption of drugs, tobacco, or alcohol...
December 2017: Acta Dermatovenerologica Croatica: ADC
Serena Bergamo, Nicola di Meo, Giuseppe Stinco, Serena Bonin, Sara Trevisini, Giusto Trevisan
Dear Editor, Adamantiades-Behçet's disease (ABD) is an inflammatory disease classified as vasculitis, which was originally diagnosed in patients with aphthous stomatitis, genital ulcerations, and ocular manifestations. However, any organ or system may be involved, particularly the central and peripheral nervous systems, joints, as well as the gastrointestinal tract. The etiology of ABD is still not fully understood, but some evidence indicates that an autoimmune process could be triggered by an infectious or environmental agent specific for the geographic region (1)...
December 2017: Acta Dermatovenerologica Croatica: ADC
T El Jammal, P-E Gavand, M Martin, A-S Korganow, A Guffroy
INTRODUCTION: First described in 1959, Hughes-Stovin syndrome is a very rare disorder combining vascular aneurysms, especially from pulmonary arteries, and thrombosis. The disease affects mostly the young male and is sometime associated with Behçet' disease. CASE REPORT: Here, we report the case of a 19-year-old man with hemoptysis and dyspnea revealing recurrent pulmonary embolisms despite efficient anticoagulant therapy. The patient subsequently developed fever and an inflammatory syndrome...
July 27, 2018: La Revue de Médecine Interne
Behcet Al, Mustafa Bogan, Suat Zengin, Mustafa Sabak, Seval Kul, M Murat Oktay, Hasan Bayram, Ertan Vuruskan
Objective: This study was designed to investigate the effects of Desert Dust Storms and Climatological Factors on Mortality and Morbidity of Cardiovascular Diseases admitted to emergency department in Gaziantep. Method: Hospital records, obtained between September 01, 2009 and January 31, 2014, from four state hospitals in Gaziantep, Turkey, were compared to meteorological and climatological data. Statistical analysis was performed by Statistical Package for the Social Science (SPSS) for windows version 24...
2018: Emergency Medicine International
Esin Avsar
No abstract text is available yet for this article.
July 2018: Indian Dermatology Online Journal
Alla Yankouskaya, Alexandra Boughey, Jane McCagh, Alison Neal, Christophe de Bezenac, Simon J Davies
OBJECTIVE: The aim of this study was to investigate the relationship between psychological representations of illness, perceived health status, and self-assessment of symptom severity in patients with Behçet disease, a rare long-term incurable condition with unclear etiology. METHODS: Using cross-sectional survey design, data on self-administered questionnaires on illness perception, health status, symptoms severity, and demographic characteristics were collected from 273 patients with Behçet disease (age range, 18-65 years)...
July 25, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Mehmet Emin Enecik, Barış Mavi, Çiğdem Yücel, Göksal Keskin, Mehmet Yıldız
BACKGROUND: Behçet's disease (BD) is a complex multisystemic disease with an unknown origin, which presents with aphthous and genital ulcers, cutaneous lesions, arthritis, ocular lesions, and defects in the gastrointestinal and central nervous systems. OBJECTIVES: In this study, we examined the relationship between serum interleukin-20 (IL-20) levels and disease activity in BD patients. MATERIAL AND METHODS: A total of 45 BD patients diagnosed according to the BD diagnosis criteria determined by the International Study Group for Behçet's Disease were included in the study...
July 26, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Katharina Schuberth, Norbert Kniess, Matthias Johann Müller, Stephan Seeliger
BACKGROUND: Behçet's disease is a multi-system disease with inflammatory infestations, in particular of the small and middle arteries and veins. Histologically, the disease presents with the image of leukocytoclastic vasculitis. The etiology of Behçet disease is unknown, but genetic factors are discussed of playing a role in its pathogenesis. There is no known autoantibody, which could serve as a diagnostic tool. The disease usually affects patients in the 3. life decade and is rare in pediatrics...
July 25, 2018: Klinische Pädiatrie
R Hurtado-García, C Trasancos Escura, J I Massa Navarrete
No abstract text is available yet for this article.
July 20, 2018: Revista Clínica Española
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