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Behcet’s Disease

Mahdi Mahmoudi, Amir Ashraf-Ganjouei, Ali Javinani, Farhad Shahram, Akira Meguro, Nobuhisa Mizuki, Nooshin Ahmadzadeh, Saeideh Jafarinejad-Farsangi, Shayan Mostafaei, Hoda Kavosi, Seyedeh Tahereh Faezi, Maassoumeh Akhlaghi, Fereydoun Davatchi
Behçet's Disease (BD) pathogenesis remains unclear, but some genetic loci and environmental factors are proposed to play a role. Here, we investigate the association of the endoplasmic reticulum aminopeptidase-1 (ERAP1) gene variants and HLA-B*51 with BD susceptibility and clinical manifestations in Iranian patients. In the study, 748 BD patients and 776 healthy individuals were included. The MGB-TaqMan Allelic Discrimination method was used to genotype 10 common missense single nucleotide polymorphisms (SNPs) and one intronic SNP in the ERAP1 gene region...
December 4, 2018: Scientific Reports
Mojtaba Mikaniki, Neda Babaee, Ebrahim Mikaniki, Mohammad Reza Hasanjani Roushan, Ali Bijani
Background: Behcet's syndrome is a disease with different aspects in its clinical manifestations. The purpose of this study was to evaluate the simultaneous presence of oral mucosal and ophthalmologic lesions in patients with Behcet's syndrome. Methods: From April 2012 to December 2014, 50 cases of Behcet's syndrome who referred to the Departments of Ophtalmology, Oral Diseases and Infectious Diseases of Babol University Medical Sciences were entered into the study...
2018: Caspian Journal of Internal Medicine
Cara Skon-Hegg, Juan Zhang, Xiumin Wu, Meredith Sagolla, Naruhisa Ota, Arthur Wuster, Jennifer Tom, Emma Doran, Nandhini Ramamoorthi, Patrick Caplazi, John Monroe, Wyne P Lee, Timothy W Behrens
Both common and rare genetic variants of laccase domain-containing 1 ( LACC1 , previously C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and systemic juvenile idiopathic arthritis. However, the functional relevance of these variants is unclear. In this study, we use LACC1-deficient mice to gain insight into the role of LACC1 in regulating inflammation. Following oral administration of Citrobacter rodentium , LACC1 knockout (KO) mice had more severe colon lesions compared with wildtype (WT) controls...
December 3, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Traci N Adams, Da Zhang, Kiran Batra, John E Fitzgerald
The hallmark of vasculitis is autoimmune inflammation of blood vessels and surrounding tissues, resulting in an array of constitutional symptoms and organ damage. The lung is commonly targeted in the more familiar ANCA-associated small vessel vasculitidies, but large and medium vessel vasculitides, including Takayasu arteritis, giant cell arteritis, polyarteritis nodosa, Behcet's disease, and necrotizing sarcoid granulomatosis, may also feature prominent pulmonary involvement. Pulmonary manifestations of these conditions include pulmonary arterial aneurysms, pulmonary hypertension, diffuse alveolar hemorrhage, pulmonary nodules, and parenchymal infiltrates...
December 2018: Respiratory Medicine
Gonca Mumcu, Fedayi Yağar, Fatma Alibaz-Öner, Nevsun İnanç, Haner Direskeneli, Tulin Ergun
This study aims to assess the relationship between illness perception and disease course and symptoms in Behçet disease (BD). One hundred ten consecutive BD patients (F/M 50/60, mean age 38.5 ± 9.88 years) and 57 patients with Psoriasis as a disease control group (F/M 28/29, mean age 48.12 ± 15.52) are included in this cross-sectional study. Illness perception is evaluated using a revised version of the Illness Perception Questionnaire (IPQ-R). In IPQ-R, the identity score reflecting the number of symptoms is higher in BD patients with musculoskeletal involvement than the others (6...
November 30, 2018: Internal and Emergency Medicine
Paola Caruso, Rita Moretti
Behçet's disease (BD) is a multisystemic vasculitis disorder of almost unknown etiology, which involves small and large vessels and affects both veins and arteries. BD is characterized by recurrent oral aphthae (the main and most recurrent symptoms), genital ulcers, variable skin lesions, arthritis, uveitis, and thrombophlebitis. Other reported symptoms concern the involvement of the gastrointestinal and the central nervous system. Neuro-Behçet's disease (NBD) is one of the main causes of long-term morbidity and mortality, making its prompt recognition and treatment fundamental to attaining a better outcome...
November 2018: Neurology India
Sho Ueda, Mitsuteru Akahoshi, Atsunobu Takeda, Yasushi Inoue, Aya Omoto, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Yojiro Arinobu, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko Horiuchi, Shin-Ichi Hikita, Takako Fukuhara, Tatsuro Ishibashi, Koh-Hei Sonoda, Koichi Akashi
OBJECTIVE: To assess the long-term efficacy and safety of infliximab (IFX) treatment for refractory uveitis associated with Behçet's disease (BD) and to identify predictors of long-term IFX therapy outcomes. METHODS: We retrospectively studied 44 consecutive BD patients with uveitis who were started on IFX therapy and analyzed the efficacy and safety of IFX and the treatment continuation rate. To determine predictors of IFX responsiveness, we analyzed the clinical characteristics of the patients who received regular maintenance therapy and those who required treatment intensification...
March 2018: European Journal of Rheumatology
Merve İris, Ezgi Özçıkmak, Aysun Aksoy, Fatma Alibaz-Öner, Nevsun İnanç, Tülin Ergun, Haner Direskeneli, Gonca Mumcu
OBJECTIVE: The aim of this study was to assess the contributing factors for oral ulcer activity in Behçet's disease (BD). METHODS: Ninety-two patients with BD (F/M: 42/50, mean age: 38.7±10.02 years) participated in this cross-sectional study. Data regarding disease-related factors, smoking patterns, and self-reported dietary/non-dietary triggering factors for oral ulcer activity were collected by a questionnaire. Treatment protocol was categorized as mild and intensive groups associated with organ involvements...
December 2018: European Journal of Rheumatology
Irmak Karaca, Melis Palamar, Suzan Guven Yilmaz, Halil Ates
PURPOSE: To evaluate the ocular surface and meibography of patients with inactive Behçet's uveitis. METHODS: Twenty-five right eyes of 25 patients with inactive Behçet's uveitis (Group 1) and 25 right eyes of 25 healthy individuals (Group 2) were enrolled. Detailed eye examination along with Schirmer 1 test, tear film break-up time (t-BUT), ocular surface staining with fluorescein and Oxford scoring, ocular surface disease index (OSDI) score assessment were performed...
November 30, 2018: Current Eye Research
O Hibberd, P Bhomra, A Ahmad
Behçet's disease is a chronic, relapsing, systemic inflammatory disease affecting the orogenital mucosa, eyes, joints, blood vessels, nervous system and intestines. The prevalence of neurological involvement varies geographically and can include psychiatric manifestations. Current evidence for a causal association between Behçet's disease and bipolar disorder is limited to a small number of case reports. We report a case of a patient with a recent diagnosis of bipolar disorder who was subsequently diagnosed with Behçet's disease...
December 2018: Journal of the Royal College of Physicians of Edinburgh
Fatih Karatas, Suleyman Sahin, Aydin Aytekin, Gokmen Umut Erdem, Ozturk Ates, Yavuz Ozisik, Sercan Aksoy, Kadri Altundag
Introduction: The relation between Behçet's disease (BD) and breast cancer (BC) is unclear. Our purpose is to investigate whether BD has an important effect on BC or vice versa. Patients and Methods: A total of 12 female BC patients with a diagnosis of BD were identified from a cohort including 5050 BC patients. The demographic data of the selected patients including previous chemotherapy (CT), radiotherapy (RT), hormonal therapy (HT), drugs used for BD, history of thrombotic events, and overall survival were examined...
October 2018: Journal of Cancer Research and Therapeutics
Matteo Becatti, Giacomo Emmi, Alessandra Bettiol, Elena Silvestri, Gerardo Di Scala, Niccolò Taddei, Domenico Prisco, Claudia Fiorillo
Behçet's syndrome (BS) is a complex disease with different organ involvement. The vascular one is the most intriguing considering the existence of a specific group of patients suffering from recurrent vascular events involving the venous and, more rarely, the arterial vessels. There are several clinical clues suggesting the inflammatory nature of thrombosis in BS, especially of the venous involvement, thus BS is considered a model of inflammation-induced thrombosis. Unique among other inflammatory conditions, venous involvement (together with the arterial one) is currently treated with immunosuppressants, rather than with anticoagulants...
November 25, 2018: Clinical and Experimental Immunology
Michelle Rosenzwajg, Roberta Lorenzon, Patrice Cacoub, Hang Phuong Pham, Fabien Pitoiset, Karim El Soufi, Claire RIbet, Claude Bernard, Selim Aractingi, Beatrice Banneville, Laurent Beaugerie, Francis Berenbaum, Julien Champey, Olivier Chazouilleres, Christophe Corpechot, Bruno Fautrel, Arsène Mekinian, Elodie Regnier, David Saadoun, Joe-Elie Salem, Jérémie Sellam, Philippe Seksik, Anne Daguenel-Nguyen, Valérie Doppler, Jéremie Mariau, Eric Vicaut, David Klatzmann
OBJECTIVE: Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential. AIM: We aimed to assess this potential and select diseases for further clinical development by cross-investigating the effects of ld-IL2 in a single clinical trial treating patients with 1 of 11 autoimmune diseases...
November 24, 2018: Annals of the Rheumatic Diseases
Isabelle Koné-Paut, Sophie Georgin Lavialle, Caroline Galeotti, Linda Rossi-Semerano, Véronique Hentgen, Léa Savey, David Saadoun, Guillaume Sarrabay, Isabelle Touitou
The spectrum of factors known to mediate autoinflammation has broadened recently to include not only interleukin-1 (IL-1) and interferon, but also abnormalities that impair NF-κB pathway negative regulation. The NF-κB pathway is activated upon contact of a ligand with tumor necrosis factor receptor 1 (TNFR1) and plays a pivotal role in triggering the inflammatory process by producing major cytokines such as IL-1, IL-6, and TNF. Negative regulation of the NF-κB pathway, which is essential to stop the inflammatory process, depends on the level of ubiquitination of the proteins associated with TNFR1 and of other intermediate compounds...
November 21, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Meral Yay, Zülal Çelik, Aysun Aksoy, Fatma Alibaz-Öner, Nevsun Inanç, Tülin Ergun, Haner Direskeneli, Gonca Mumcu
OBJECTIVES: The aim of the study was to examine whether oral health as an infection focus could mediate disease course in patients with Behçet's disease (BD). METHODS: In the study, oral health of 194 BD patients was examined at baseline and follow-up periods. The reasons for last dental visits were recorded as tooth extraction or regular control visits/planned treatments at the end of follow-up period. The Behçet's disease severity score was calculated with higher scores indicating a more severe course...
November 22, 2018: Journal of Oral Rehabilitation
Nadege Wesner, Louis Drevon, Alexis Guedon, Jean Baptiste Fraison, Benjamin Terrier, Salim Trad, Jean Emmanuel Kahn, Achille Aouba, Jerome Gillard, Matthieu Ponsoye, Thomas Hanslik, Clement Gourguechon, Eric Liozon, Kamel Laribi, Julien Rossignol, Olivier Hermine, Philippe Seksik, Lionel Adès, Fabrice Carrat, Pierre Fenaux, Arsène Mekinian, Olivier Fain
We report the 11 cases of +8-MDS/MPN associated with Behcet's-like syndrome and compare them with Behcet's disease and Crohn's disease, pool with literature cases for analysis. Data for patients with +8-MDS/MPN and Behçet's-like syndrome were collected from MINHEMON. Eleven patients had Behcet's-like syndrome and +8-MDS/MPN (median age 75 years [IQR 65-87]; M/F ratio 0.8). MDS and Behcet's-like syndrome were diagnosed at the same time (7/11, 64%). By comparison with 63 patients with idiopathic Behcet's disease without associated MDS, those with Behcet's-like syndrome and +8-MDS/MPN were older (median 75 vs 48 years; p = ...
November 20, 2018: Leukemia & Lymphoma
Hadiseh Kavandi, Mehrzad Hajialilo, Alireza Khabbazi
Objective: Nigella sativa (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet's disease (BD). Materials and methods: In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the treatment (n=37) and control (n=34) groups. Finally, 32 and 30 patients in the treatment and control groups, respectively, completed the study...
November 2018: Avicenna Journal of Phytomedicine
Vitorino Modesto Dos Santos
No abstract text is available yet for this article.
October 2018: Turkish Thoracic Journal
Muhammet Çınar, Emre Tekgöz, Fatma İlknur Çınar, Sedat Yılmaz
No abstract text is available yet for this article.
October 2018: Turkish Thoracic Journal
Mergita Ferizi, Antigona Gerqari, Mybera Ferizi
BACKGROUND: Behçet's syndrome is associated with inflammation of various areas of the body. Sy. Behcet is a rare, chronic, recurrent disease characterised by changes in the: Arteries that supply blood to the body's tissues, veins that take the blood back to the lungs, the back of the eye's retina, brain, joints, skin and bowels. There is a close correlation between the geographical distribution of HLA-B51 and its prevalence. In the etiopathogenesis, there are indications of genetic susceptibility associated with environmental influence...
October 25, 2018: Open Access Macedonian Journal of Medical Sciences
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