keyword
https://read.qxmd.com/read/33142293/decreased-expression-of-sirt1-contributes-to-ocular-beh%C3%A3-et-s-disease-progression-via-th17-and-th22-response
#1
JOURNAL ARTICLE
Manyun Xie, Yan Yang
BACKGROUND: Previous studies have indicated that Sirtuin 1 (Sirt1) plays an important role in suppressing inflammatory responses in many diseases. However, the Sirt1 levels and role of Sirt1 in ocular Behçet's disease (OBD) have not been fully elucidated. OBJECTIVE: The objective of this study was to investigate the role of Sirt1 in the pathogenesis of OBD. METHODS: Sirt1 and cytokine levels were measured using ELISA. Cell viability was determined using the Cell Counting Kit-8...
2021: Ophthalmic Research
https://read.qxmd.com/read/33139078/-beh%C3%A3-et-s-like-syndrome-and-other-dysimmunitary-manifestations-related-to-myelodysplastic-syndromes-with-trisomy-8
#2
JOURNAL ARTICLE
N Wesner, P Fenaux, V Jachiet, L Ades, O Fain, A Mekinian
Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies which are also characterised by immune dysregulation. The impaired immune response is mainly due to T lymphocytes (CD8 and T regulatory cells) with increased cell apoptosis. MDS could be associated in some cases with various clinical dysimmune features; however, only MDS with trisomy 8 is correlated with particular clinical phenotype. The latter is mainly Behçet's-like disease which includes orogenital aphtosis, skin features and severe ulcerative digestive disease of ileocaecal distribution...
March 2021: La Revue de Médecine Interne
https://read.qxmd.com/read/33134813/ocular-involvement-in-beh%C3%A3-et-s-disease-relevance-of-new-diagnostic-tools
#3
JOURNAL ARTICLE
Maria Giulia Tinti, Filippo Vaira, Michele Inglese, Gaetano Serviddio, Salvatore De Cosmo, Daniela Marotto, Angelo De Cata
No abstract text is available yet for this article.
2020: Rheumatology Advances in Practice
https://read.qxmd.com/read/33129321/therapeutic-options-for-patients-with-rare-rheumatic-diseases-a-systematic-review-and-meta-analysis
#4
REVIEW
Tim T A Bender, Judith Leyens, Julia Sellin, Dmitrij Kravchenko, Rupert Conrad, Martin Mücke, Matthias F Seidel
BACKGROUND: Rare diseases (RDs) in rheumatology as a group have a high prevalence, but randomized controlled trials are hampered by their heterogeneity and low individual prevalence. To survey the current evidence of pharmacotherapies for rare rheumatic diseases, we conducted a systematic review and meta-analysis. Randomized controlled trials (RCTs) of RDs in rheumatology for different pharmaco-interventions were included into this meta-analysis if there were two or more trials investigating the same RD and using the same assessment tools or outcome parameters...
October 31, 2020: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/33125440/succinivibrionaceae-is-dominant-family-in-fecal-microbiota-of-beh%C3%A3-et-s-syndrome-patients-with-uveitis
#5
JOURNAL ARTICLE
Duygu Tecer, Feride Gogus, Ayse Kalkanci, Merve Erdogan, Murat Hasanreisoglu, Çagri Ergin, Tarkan Karakan, Ramazan Kozan, Seda Coban, Kadir Serdar Diker
Behçet's Syndrome (BS) is a multisystem vasculitis with various clinical manifestations. Pathogenesis is unclear, but studies have shown genetic factors, innate immunity and autoinflammation to have an important role in the disease course. Diversity in the microbial community of gut microbiota may significantly contribute to the activation of the innate immune system. The clinical features of BS present themselves in clusters and each cluster may be a consequence of different disease mechanisms. For this reason we aimed to investigate the gut microbiota of BS patients with uveitis...
2020: PloS One
https://read.qxmd.com/read/33124578/intestinal-microbiota-composition-of-patients-with-beh%C3%A3-et-s-disease-differences-between-eye-mucocutaneous-and-vascular-involvement-the-rheuma-biota-study
#6
JOURNAL ARTICLE
Nazife Sule Yasar Bilge, Vicente Pérez Brocal, Timucin Kasifoglu, Ugur Bilge, Nilgun Kasifoglu, Andrés Moya, Ener Cagri Dinleyici
OBJECTIVES: Changes in microbiota composition affect the aetiology and patho-genesis of chronic diseases, including Behçet's disease (BD). However, no studies have analysed the potential gut microbiota changes among different clinical forms of BD. This study evaluated the intestinal microbiota composition of patients with BD and healthy controls and also compared differences between patients with BD with respect to eye, mucocutaneous, and vascular involvement. METHODS: In this prospective cohort study, 27 patients diagnosed with BD according to the International Study Group criteria and 10 age- and sex-matched healthy controls were included...
September 2020: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/33124572/hla-b-51-and-its-main-subtypes-in-brazilian-patients-with-beh%C3%A3-et-s-disease
#7
JOURNAL ARTICLE
Joice Moraes F M Belem, Ana Maria Fraga, Luis Eduardo Coelho Andrade, Alexandre W S de Souza
OBJECTIVES: This study aimed to evaluate the frequency of HLA-B*51 and its subtypes in Brazilian patients with Behçet's disease (BD) and healthy controls (HC) and to assess possible associations with disease manifestations. METHODS: A cross-sectional study with sequential BD patients and HC. HLAB*51 presence was determined by sequence-specific polymerase chain reaction (SSP-PCR) and HLA-B*51 subtypes by the Sanger sequencing method. RESULTS: Eighty-three BD patients and 258 HC were evaluated...
September 2020: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/33124565/efficacy-and-safety-of-certolizumab-pegol-in-pregnant-women-with-uveitis-recommendations-on-the-management-with-immunosuppressive-and-biologic-therapies-in-uveitis-during-pregnancy
#8
MULTICENTER STUDY
Diana Prieto-Peña, Mónica Calderón-Goercke, Alfredo Adán, Lillian Chamorro-López, Olga Maíz-Alonso, Juan R De Dios-Jiménez Aberásturi, Raúl Veroz, Soledad Blanco, José M Martín-Santos, Francisco Navarro, Adela Gallego, Senén González-Suárez, Arantxa Conesa, Andrea García-Valle, Miguel Cordero-Coma, Nieves Pardiñas-Barón, Rosalía Demetrio, Vanesa Calvo-Río, Víctor M Martínez-Taboada, Santos Castañeda, José L Hernández, Miguel A González-Gay, Ricardo Blanco
OBJECTIVES: Clinicians often face the challenge of providing effective and safe therapy for pregnant women with uveitis. Certolizumab pegol (CZP) differs from other anti-TNFα agents due to its limited placental transfer. In this study we assessed the efficacy of CZP in pregnant women with uveitis. We also provided information on outcomes of pregnant women and neonates exposed to CZP. METHODS: We carried out a multicentre study of women with uveitis who received CZP during pregnancy and their neonates...
January 2021: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/33124559/differential-expression-of-novel-genes-and-signalling-pathways-of-senescent-cd8-t-cell-subsets-in-beh%C3%A3-et-s-disease
#9
JOURNAL ARTICLE
So Min Kim, Mi Jin Park, Sun Park, Jae Youn Cheng, Eun-So Lee
OBJECTIVES: Behçet's disease (BD) is a rare disease characterised by recurrent mucocutaneous ulceration and chronic multi-systemic inflammation; however, its pathogenic mechanisms and biomarkers have not been fully discovered. Previously, we found that peripheral blood CD8+CD27-CD28- T cell frequency was higher in patients with BD than in healthy controls (HCs). In this study, we used global gene expression analysis to identify candidate genes that might be related to pathogenesis or developed as biomarkers in two CD8+ T cell subsets from BD patients and HCs...
September 2020: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/33123395/successful-pregnancy-in-a-case-of-beh%C3%A3-et-s-disease-after-treatment-with-prednisolone
#10
Shogo Nishii, Koushi Yamaguchi, Mitsuyoshi Amita, Takakazu Saito, Hidekazu Saito, Akihiko Sekizawa
A 34-year-old woman (gravida 1, para 0) visited the Division of Reproductive Medicine/National Center for Child Health and Development due to infertility; she had also been suffering from incompletely treated genital ulcers and stomatitis for 10 years. This case was diagnosed as an incomplete-type Behçet's disease (BD) at the Department of Maternal-Fetal Biology/National Center for Child Health and Development. Since no apparent abnormality was found in the general infertility test, artificial insemination with the husband's semen (AIH) was performed for the patient with unexplained infertility, which failed...
2020: Case Reports in Obstetrics and Gynecology
https://read.qxmd.com/read/33115969/characterization-of-venous-involvement-in-vasculo-beh%C3%A3-et-disease
#11
JOURNAL ARTICLE
Na Hyeon Lee, Miju Bae, Moran Jin, Sung Woon Chung, Chung Won Lee, Chang Ho Jeon
BACKGROUND: Behçet disease is a chronic inflammatory disorder with a varying etiology. Herein, we report the involvement of peripheral veins in Behçet disease and discuss the treatment thereof. METHODS: Thirty-four patients with venous involvement in vasculo-Behçet disease were retrospectively analyzed over 15 years. We reviewed the clinical manifestations, treatment choices, and complications of these patients. RESULTS: Deep vein thrombosis (DVT) was observed in 24 patients (70...
December 5, 2020: Korean Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/33101300/association-of-clinical-phenotypes-in-haploinsufficiency-a20-ha20-with-disrupted-domains-of-a20
#12
JOURNAL ARTICLE
Yu Chen, Zhenghao Ye, Liping Chen, Tingting Qin, Ursula Seidler, De'an Tian, Fang Xiao
Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the A20 ovarian tumor (OTU) domain and/or the zinc finger (ZnF) domain. This study aims at exploring the association between the various manifestations of HA20 and different domains disruption of A20. Methods: We reviewed the HA20 cases in previous literature and summarized the clinical features, TNFAIP3 mutation loci and the disrupted domains caused by different sites and patterns of mutations...
2020: Frontiers in Immunology
https://read.qxmd.com/read/33100196/colchicine-an-ancient-drug-with-multiple-benefits
#13
JOURNAL ARTICLE
Georges El Hasbani, Ali Jawad, Imad Uthman
The history of colchicine dates to ancient Egyptians when it was used for alleviation of swelling and pain. Although its popularity varied throughout the years, colchicine has been a mainstay for the treatment of several diseases, mainly rheumatic and cardiac ones. The mechanism of action of the drug involves several intracellular and extracellular targets, although interaction with tubulin is the most described. Based on several clinical trials and meta-analyses, colchicine is safely recommended as a monotherapy or as an add-on for the treatment and prevention of recurrent pericarditis, post-pericardiotomy syndrome, gout, pseudogout, familial Mediterranean fever (FMF), and Behçet's disease (BD)...
2021: Current Pharmaceutical Design
https://read.qxmd.com/read/33099967/behcet-s-disease-and-breast-cancer
#14
JOURNAL ARTICLE
Kadri Altundag
No abstract text is available yet for this article.
July 2020: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/33089014/spontaneous-resolution-of-unilateral-behcet-s-associated-neuroretinitis
#15
George Skopis, Sneha Padidam, Brian Do
PURPOSE: Behcet's disease is an immune-mediated condition which can commonly have ocular involvement. We present a case of Behcet's associated neuroretinitis, which is a rare ocular manifestation of Behcet's disease. OBSERVATIONS: The patient experienced significant improvement in her neuroretinitis without initiation of treatment. After 28 days of observation there was spontaneous resolution of exam findings and return of Snellen visual acuity to 20/20. CONCLUSIONAND IMPORTANCE: There are only two other cases reported in the literature of Behcet's associated neuroretinitis...
December 2020: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/33087144/correlation-of-clinical-signs-and-symptoms-of-beh%C3%A3-et-s-disease-with-mean-platelet-volume-mpv-and-red-cell-distribution-width-rdw
#16
JOURNAL ARTICLE
Maryam Masoumi, Soraya Shadmanfar, Fereydoun Davatchi, Farhad Shahram, Massoomeh Akhlagi, Tahereh Faezi, Hoda Kavosi, Soroush Moradi, Javad Balasi
BACKGROUND: A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with Behçet's disease (BD) as well the relationship between MPV and RDW and disease activity score on the Iranian Behçet's Disease Dynamic Activity Measurement (IBDDAM). METHODS: This cross-sectional study included 319 patients with BD for whom demographic and epidemiological data, IBDDAM scores, and duration of illness was recorded...
October 21, 2020: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/33087010/recurrent-myocardial-infarction-associated-with-vasculo-beh%C3%A3-et-s-disease-a-case-report
#17
JOURNAL ARTICLE
Kazuyuki Tsuboi, Masao Tamura, Naohiko Sone, Kenji Kaihotsu, Toshihiko Tomita, Naoto Azuma, Masayasu Kitano, Kyosuke Abe, Goh Tsuji, Hiroto Miwa, Hajime Sano, Kiyoshi Matsui
A 39-year-old Japanese man presented with chest oppression in February 2017. Electrocardiogram showed ST-elevation myocardial infarction (MI), and cardiac catheterisation revealed thrombotic occlusion of the right coronary artery (RCA), which was treated with thrombectomy, and he received warfarin. Three days after discharge, he complained of chest oppression again, and re-cardiac catheterisation showed thrombi occlusion of the circumflex artery (LCX) and 90% stenosis with thrombosis in the proximal site of the anterior descending artery (LAD) and RCA...
July 2020: Modern rheumatology case reports
https://read.qxmd.com/read/33083081/bilateral-retrobulbar-optic-neuritis-as-the-first-manifestation-of-neuro-beh%C3%A3-et-disease
#18
Mohsen Jari, Taiiebeh Mohammadi, Ensiyeh Taheri
BACKGROUND: Behçet disease (BD) is a polygenic and chronic autoinflammatory multisystem vasculitis. Acute optic neuritis has been rarely reported in patients with BD, especially in children. Case Presentation . We reported an 8-year-old girl with a sudden visual loss and color vision impairment. The patient had a history of recurrent oral aphthous ulcers, genital ulcers, and chronic abdominal pain. On ophthalmic examination, anterior and posterior chambers and funduscopy of both eyes were normal...
2020: Case Reports in Rheumatology
https://read.qxmd.com/read/33082762/other-iatrogenic-immunodeficiency-associated-lymphoproliferative-disorders-diffuse-large-b-cell-lymphoma-type-in-a-patient-with-beh%C3%A3-et-s-disease-treated-with-cyclosporine-a
#19
Yuka Urano, Rintaro Ohe, Akane Yamada, Takanobu Kabasawa, Kazushi Suzuki, Takumi Kitaoka, Nobuyuki Tamazawa, Naing Ye Aung, Aya Utsunomiya, Tomomi Toubai, Kenichi Ishizawa
A 40-year-old man had been treated for Behçet's disease (BD) with cyclosporine A (CsA) for 14 years. He presented multiple lymphadenopathies with fever. Histological examination of surgical biopsy showed other iatrogenic immunodeficiency-associated lymphoproliferative disorders, diffuse large B-cell lymphoma type with positivity for Epstein-Barr virus encoding RNA-1 (EBER-1). BCL2-IgH , BCL6-IgH , and MYC-IgH translocations were not detected. CsA was stopped, and R-CHOP therapy was initiated. However, his lymphoma was chemotherapy resistant and rapidly progressed...
September 2020: Case Reports in Oncology
https://read.qxmd.com/read/33066995/cerebral-venous-thrombosis-in-a-sub-saharan-african-country-a-preliminary-monocentric-study-of-a-70-case-series-at-the-neurology-department-of-fann-teaching-hospital-in-dakar-senegal
#20
JOURNAL ARTICLE
N M Gaye, R Diagne, A M Diop, M Ka, A P Senghor, A B Mbodji, K A Mbaye, S S Mbacké, S A A Fall, M Fall, O Cissé, N S Diagne, M S Diop-Sène, A M Basse-Faye, A D Sow, M M Sarr, L B Seck, K Touré, M Ndiaye, A G Diop
INTRODUCTION: Cerebral venous thrombosis (CVT) are underdiagnosed in sub-saharan Africa where publications are uncommon. Our study aim was to describe the CVT diagnostic and therapeutic features through a senegalese case series. PATIENTS AND METHOD: A monocentric retrospective and prospective study was conducted at the adult Neurology department of Fann Teaching Hospital in Dakar (Senegal), between January 01, 2013 and April 30, 2020. It had included all CVT cases diagnosed by neurovascular imaging...
June 2021: Revue Neurologique
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