Kazeem Akano, Bayo Fatunmbi, Godwin Ntadom, Adejumoke I Ayede, Temitope Aderoyeje, Adewale Bakre, Omobolaji T Alebiosu, Odafe Akpoborie, Chukwuebuka Okafor, Grace O Gbotosho, Onikepe A Folarin, Joy C Ebenebe, Jose Ambe, Robinson Wammanda, Nma Jiya, Finomo Finomo, George Emechebe, Olugbenga Mokuolu, Chimere Agomo, Stephen Oguche, Christian Happi, Akintunde Sowunmi
In non-anaemic children with malaria, early-appearing anaemia (EAA) is common following artemisinin-based combination treatments (ACTs) and it may become persistent (PEAA). The factors contributing to and kinetics of resolution of the deficit in haematocrit from baseline (DIHFB) characteristic of ACTs-related PEAA were evaluated in 540 consecutive children with malaria treated with artemether-lumefantrine, artesunate-amodiaquine or dihydroartemisinin-piperaquine. Asymptomatic PEAA occurred in 62 children. In a multiple logistic regression model, a duration of illness ≤3 days before presentation, haematocrit <35% before and <25% one day after treatment initiation, drug attributable fall in haematocrit ≥6%, and treatment with dihydroartemisinin-piperaquine independently predicted PEAA...
2019: Parasite: Journal de la Société Française de Parasitologie