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https://www.readbyqxmd.com/read/30515097/clofazimine-but-not-isoniazid-or-rifampicin-augments-platelet-activation-in-vitro
#1
Ronald Anderson, Annette J Theron, Jan G Nel, Chrisna Durandt, Moloko C Cholo, Charles Feldman, Gregory R Tintinger
Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, concerns remain about the cardiotoxic potential of this agent. Accordingly, the current study was undertaken with the primary objective of investigating the effects of clofazimine, on the reactivity of human platelets in vitro , a seemingly unexplored, mechanism of cardiotoxicity. Platelet-rich plasma (PRP) prepared from the blood of healthy, adult humans was treated with clofazimine (0...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30508260/the-efficacy-of-iv-tissue-plasminogen-activator-for-restoring-cerebral-blood-flow-in-the-hours-immediately-after-administration-in-patients-with-acute-stroke
#2
Shahram Majidi, Alexis N Simpkins, Richard Leigh
BACKGROUND AND PURPOSE: Timely restoration of tissue-level cerebral blood flow is the goal of thrombolytic therapy in patients presenting with an acute ischemic stroke. We aimed to identify the incidence and predictors of reperfusion immediately following treatment with intravenous recombinant tissue plasminogen activator (IV rt-PA). METHODS: This study included patients with acute ischemic stroke triaged using magnetic resonance imaging (MRI) with perfusion-weighted imaging (PWI) and treated with IV rt-PA who were subsequently enrolled in our natural history study and underwent repeat MRI with PWI approximately 2 hours posttreatment...
December 3, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30507857/the-effectiveness-of-junctional-tourniquets-a-systematic-review-and-meta-analysis
#3
Shane Smith, John White, Kerollos Nashat Wanis, Andrew Beckett, Vivian C McAlister, Richard Hilsden
BACKGROUND: Junctional tourniquets have been incorporated into tactical combat casualty care for junctional vascular trauma. They apply external compression to stop blood flow in the groin and axilla. OBJECTIVES: The primary outcome was effectiveness in achieving arterial occlusion. Secondary outcomes included time to application and pain scores. DATA SOURCES: Medline and EMBASE databases were searched. STUDY APPRAISAL AND SYNTHESIS METHODS: A random effects meta-analysis was conducted to estimate the average effectiveness and time to effective application for each device...
November 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30507846/acute-in-vivo-evaluation-of-the-pittsburgh-pediatric-ambulatory-lung
#4
Alexandra G May, Ryan A Orizondo, Brian J Frankowski, Peter D Wearden, William J Federspiel
Respiratory failure is a significant problem within the pediatric population. A means of respiratory support that readily allows ambulation could improve treatment. The Pittsburgh Pediatric Ambulatory Lung (P-PAL) is being developed as a wearable pediatric pump-lung for long-term respiratory support and has previously demonstrated positive benchtop results. This study aimed to evaluate acute (4-6 hours) in vivo P-PAL performance, as well as develop an optimal implant strategy for future long-term studies. The P-PAL was connected to healthy sheep (n = 6, 23-32 kg) via cannulation of the right atrium and pulmonary artery...
November 21, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/30506681/seven-consecutive-days-of-remote-ischaemic-preconditioning-improves-cutaneous-vasodilatory-capacity-in-young-adults
#5
James A Lang, Jahyun Kim, Warren D Franke, Lauro C Vianna
KEY POINTS: Remote ischaemic preconditioning (RIPC), induced by brief bouts of ischaemia followed by reperfusion, confers vascular adaptations that protect against subsequent bouts of ischaemia. However, the effect of RIPC repeated over several days on the human microcirculation is unknown. Using skin as a model, microvascular function was assessed at a control and a NO-inhibited area of skin before, after, and 1 week after administering seven consecutive days of repeated RIPC on the contralateral arm...
December 2, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/30497173/comparison-of-practical-methods-in-clinical-sites-for-estimating-cerebral-blood-flow-during-balloon-test-occlusion
#6
(no author information available yet)
OBJECTIVEThe authors sought to compare methods of measurement for venous phase delay (VPD) or mean stump pressure (MSTP) to rank their potential to predict ischemic tolerance during balloon test occlusion in the internal carotid artery, exploring a more correlative and convenient way to measure cerebral blood flow (CBF) that could be utilized even in the acute phase or in institutions not adequately equipped to measure CBF during the test.METHODSX-ray angiography perfusion analysis using diagnostic digital subtraction angiography (DSA) equipment enables 1-step examination (without any room-to-room transfer of patients) to measure CBF, VPD, and MSTP completely simultaneously, which has not been accomplished by any previous perfusion studies...
November 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30497121/-clipping-for-large-paraclinoid-internal-carotid-artery-aneurysms-by-non-fluoroscopic-occlusion-via-a-micro-bone-window-frontolateral-approach
#7
H Y Wang, Y Zhao, H Zhang, Y K Gao, W W Xin, J Z Cui, S Y Yue, S Y Yang, J N Zhang, X Y Yang
Objective: To evaluate the clinical value and outcomes of technical improvement of hybrid operatical clipping for large paraclinoid internal carotid artery aneurysms. Methods: A review was conducted on 18 cases of large paraclinoid internal carotid artery aneurysm which were clipped by balloon non-fluoroscopic occlusion of the parent artery via a micro-bone window frontolateral approach in hybrid operating room at Neurosurgery Department of Tianjin Medical University General Hospital from June 2014 to December 2017...
December 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/30496562/a-direct-aspiration-first-pass-technique-in-japanese-real-world-clinical-setting
#8
Junji Uno, Katsuharu Kameda, Ryosuke Otsuji, Nice Ren, Shintaro Nagaoka, Kazushi Maeda, Yoshiaki Ikai, Hidefuku Gi
BACKGROUND: It is debatable whether mechanical thrombectomy has benefits in a real-world setting outside the more rigid and selective clinical trial environment. OBJECTIVE: To evaluate clinical outcomes, efficacy, and safety of mechanical thrombectomy in single-center retrospective cohort case series. METHODS: We reviewed prospectively collected data from our large-vessel occlusion stroke database to identify patients undergoing mechanical thrombectomy using Penumbra catheters (Penumbra, Almeida, California) as first-line devices...
November 28, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30488737/progression-in-vascular-cognitive-impairment-pathogenesis-neuroimaging-evaluation-and-treatment
#9
Xin Zhang, Jiabin Su, Chao Gao, Wei Ni, Xinjie Gao, Yuxin Li, Jun Zhang, Yu Lei, Yuxiang Gu
Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g., large vessel occlusion and small vessel dysfunction); hemorrhagic factors (e.g., intracerebral hemorrhage and subarachnoid hemorrhage); and other factors (combined with Alzheimer's disease). Clinical evaluations of VCI mainly refer to neuropsychological testing and imaging assessments, including structural and functional neuroimaging, with different advantages...
November 29, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/30485185/endoscope-versus-microscope-integrated-near-infrared-indocyanine-green-videoangiography-in-aneurysm-surgery
#10
(no author information available yet)
OBJECTIVEThe quality of surgical treatment of intracranial aneurysms is determined by complete aneurysm occlusion while preserving blood flow in the parent, branching, and perforating arteries. For a few years, there has been a nearly noninvasive and cost-effective technique for intraoperative flow evaluation: microscope-integrated indocyanine green videoangiography (mICG-VA). This method allows for real-time information about blood flow in the aneurysm and the involved vessels, but its limitations are seen in the evaluation of structures located in the depth of the surgical field, especially through small craniotomies...
October 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30478805/acute-median-arcuate-ligament-syndrome-after-pancreaticoduodenectomy
#11
Daisuke Imai, Takashi Maeda, Huanlin Wang, Takahiro Ohmine, Keitaro Edahiro, Makoto Edagawa, Tomoyoshi Takenaka, Shohei Yamaguchi, Kozo Konishi, Shinichi Tsutsui, Hiroyuki Matsuda
BACKGROUND: Median arcuate ligament syndrome (MALS) can cause severe complications after pancreaticoduodenectomy (PD). Most of the reported cases of MALS have been diagnosed perioperatively and can be treated efficiently by interventional radiology or division of the median acute ligament (MAL) fibers. CASE REPORT: A 69-year-old woman underwent PD with resection of the SMV for pancreatic head cancer. Intraoperative exploration showed normal anatomy of the celiac trunk...
November 26, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/30476599/reproducibility-of-hemodynamic-cardiac-autonomic-modulation-and-blood-flow-assessments-in-patients-with-intermittent-claudication
#12
Aluísio Andrade-Lima, Marcel Chehuen, Natan Silva Junior, Rafael Fecchio, Tiago Peçanha, Leandro Brito, Roberto Miyasato, Anthony S Leicht, Cláudia L M Forjaz
OBJECTIVE: To identify, in patients with peripheral artery disease and intermittent claudication (IC), the reproducibility of heart rate (HR), blood pressure (BP), rate pressure product (RPP), heart rate variability (HRV), and forearm and calf blood flow (BF) and vasodilatory assessments. METHODS: Twenty-nine patients with IC underwent test and retest sessions, 8-12 days apart. During each session, HR, BP, HRV, BF and vasodilatory responses were measured by electrocardiogram, auscultation, spectral analysis of HRV (low frequency, LFR-R ; high frequency, HFR-R ) and strain gauge plethysmography (baseline BF, post-occlusion BF, post-occlusion area under the curve, AUC)...
November 23, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30475660/blood-flow-restricted-training-for-lower-extremity-muscle-weakness-due-to-knee-pathology-a-systematic-review
#13
Sue Barber-Westin, Frank R Noyes
CONTEXT: Blood flow-restricted training (BFRT) has been suggested to treat lower extremity muscle weakness. The efficacy of BFRT for muscle problems related to knee pathology is unclear. OBJECTIVE: To determine whether BFRT (1) improves muscle strength and cross-sectional area (CSA) for chronic knee-related lower extremity atrophy and (2) prevents muscle atrophy after knee surgery. DATA SOURCES: A systematic review of the literature from 1974 to 2017 was conducted using the PubMed and Cochrane databases...
November 26, 2018: Sports Health
https://www.readbyqxmd.com/read/30472381/the-protective-role-of-intermedin-in-promoting-angiogenesis-during-renal-fibrosis
#14
Honglin Dong, Yun Zhou, Yanhon Wang, Qin Zhou, Yan Zhang, Xiaofang Gan, Yankong Luo, Rongshan Li
BACKGROUND: Renal fibrosis promotes the progression of chronic renal disease to end-stage renal disease. Microvascular damage and loss play an important role in renal fibrosis. Intermedin (IMD) is expressed mainly in the heart and kidney. IMD has been shown to increase renal blood flow and reduce the loss of glomerular and surrounding renal tubules, but its role in mediating microvascular damage in renal fibrosis remains to be elucidated. Here, we investigated the effects of IMD on microvascular damage in a renal fibrosis model...
November 22, 2018: Gene
https://www.readbyqxmd.com/read/30470847/automated-ct-perfusion-imaging-versus-non-contrast-ct-for-ischemic-core-assessment-in-large-vessel-occlusion
#15
Anderson Chun On Tsang, Stephanie Lenck, Christopher Hilditch, Patrick Nicholson, Waleed Brinjikji, Timo Krings, Vitor M Pereira, Frank L Silver, Joanna D Schaafsma
PURPOSE: There is increasing use of automated computed tomography perfusion (CTP) to aid thrombectomy decision in emergent large vessel occlusion. It is important to understand the performance of these software packages in predicting ischemic core and tissue-at-risk in the real-world setting. The aim of this study was to evaluate whether ischemic core on non-contrast CT (NCCT) and automated CTP correspond and predict infarct extent after thrombectomy for ischemic stroke. METHODS: Consecutive patients with acute anterior circulation large vessel occlusion undergoing successful thrombectomy (TICI 2b/3) were studied...
November 23, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/30468528/a-method-to-standardize-the-blood-flow-restriction-pressure-by-an-elastic-cuff
#16
Takashi Abe, J Grant Mouser, Scott J Dankel, Zachary W Bell, Samuel L Buckner, Kevin T Mattocks, Matthew B Jessee, Jeremy P Loenneke
Blood flow restriction training using a practical (non-pneumatic) elastic-cuff has recently increased in popularity. However, a criticism of this method is that the pressure applied and the amount of blood flow restriction induced is unknown. The aim was to quantify blood flow following the application of an elastic-cuff and compare that to what is observed using a more traditional pressurized nylon-cuff. Thirty-five young participants (16 men and 19 women) visited the laboratory once for testing. In a randomized order (one condition per arm), an elastic-cuff (5cm wide) was applied to one arm and blood flow was measured following the cuff being pulled to two distinct lengths; 10% and 20% of the resting length based on arm circumference...
November 23, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/30467489/early-detection-of-cerebral-infarction-with-middle-cerebral-artery-occlusion-with-functional-near-infrared-spectroscopy-a-pilot-study
#17
Hyuksool Kwon, Kyuseok Kim, You Hwan Jo, Min Ji Park, Sang-Bae Ko, Tae Jung Kim, Jihoon Kang, Hyeon-Min Bae, Ji Eun Lee
Background: NIRSIT, a functional near-infrared spectroscopy (fNIRS) device with 204 channels, can measure oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in non-pulsatile blood flow non-invasively using the absorption difference between HbO2 and HbR at a wavelength of 700-1,000 nm and can display the perfusion status in real time. Objective: We applied NIRSIT to patients with stroke to evaluate the usefulness of NIRSIT as an fNIRS device for the early detection of stroke. Methods: We performed a prospective pilot study in an emergency department (ED)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30460135/contactless-monitoring-of-the-blood-flow-changes-in-upper-limbs
#18
Valeriy V Zaytsev, Serguei V Miridonov, Oleg V Mamontov, Alexei A Kamshilin
Vasomotor reactivity, which is important to estimate neurogenic regulation of blood vessels in patients with different pathologies, is still assessed by occlusion plethysmography using sensors contacting the limbs. Recently we proposed a contactless approach for measuring blood flow changes during venous occlusion using imaging photoplethysmography [Kamshilin et al., Sci. Rep.7, 4642017]. In this work, the response of the vascular system on the occlusion was studied simultaneously by contact air-plethysmography system and remote optical system under illumination by incoherent polarized green light...
November 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/30451303/selective-embolization-with-magnetized-microbeads-using-magnetic-resonance-navigation-in-a-controlled-flow-liver-model
#19
François Michaud, Ning Li, Rosalie Plantefève, Zeynab Nosrati, Charles Tremblay, Katayoun Saatchi, Gerald Moran, Alexandre Bigot, Urs O Häfeli, Samuel Kadoury, An Tang, Pierre Perreault, Sylvain Martel, Gilles Soulez
PURPOSE: To demonstrate the feasibility of using a custom gradient sequence on an unmodified 3T magnetic resonance imaging (MRI) scanner to perform magnetic resonance navigation (MRN) by investigating the blood flow control method in vivo, reproducing the obtained rheology in a phantom mimicking porcine hepatic arterial anatomy, injecting magnetized microbead aggregates through an implantable catheter, and steering the aggregates across arterial bifurcations for selective tumor embolization...
November 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/30445134/the-association-between-near-infrared-spectroscopy-derived-and-flow-mediated-dilation-assessment-of-vascular-responsiveness-in-the-arm
#20
Rogerio N Soares, Yasina B Somani, David N Proctor, Juan M Murias
INTRODUCTION: Following a period of blood flow occlusion, the near-infrared spectroscopy (NIRS)-derived reperfusion slope of the oxygen saturation signal (StO2 ) is a measure of microvascular responsiveness that has been shown to be positively correlated with flow-mediated dilation (FMD) assessment of conduit artery function in the lower limb vasculature. Given that previously established differences in structure and function of the vessels in the upper compared to the lower limbs may change this relationship, investigating whether this correlation between the reperfusion slope of the StO2 and the FMD response is maintained in upper limbs is important...
November 13, 2018: Microvascular Research
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