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Blood flow occlusion

Paolo Sapienza, Filippo Napoli, Elvira Tartaglia, Luigi Venturini, Antonio V Sterpetti, Gioia Brachini, Sergio Gazzanelli, Andrea Mingoli
BACKGROUND: Femoral prosthetic patch is a surgical procedure frequently used to treat atherosclerotic lesions involving femoral artery bifurcation. Even though it is an easy to perform procedure, surgical management of complications, first of all graft infection, may be challenging, with a high morbidity and mortality risk for patients. We report our experience on surgical treatment of femoral patch infection. MATERIALS AND METHODS: Between April 2012 and April 2018, 26 patients (26 limbs) were referred to the Emergency Department at our Institution, for the treatment of femoral prosthetic patch infection...
October 17, 2018: Annals of Vascular Surgery
Xiaoyang Tao, Yin Liu, Jun Chen, Li Xu, Zhijie Zhou, Haiyan Lei, Yiming Yin
BACKGROUND Moyamoya disease (MMD) is an idiopathic disease caused by progressive steno-occlusion of the distal internal carotid artery. Ideal surgical treatment for adult patients with ischemic-type MMD has not been achieved. The aim of this study was to evaluate the efficacy of single-barrel superficial temporal artery-middle cerebral artery (STA-MCA) bypass in treatment for adult patients with ischemic-type MMD by analyzing clinical and radiological data retrospectively. MATERIAL AND METHODS The present study included 37 patients with non-hemorrhagic MMD, including 21 women and 16 men (21~55 years old, mean age 38...
October 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Teruyo Kida, Josef Flammer, Hidehiro Oku, Katarzyna Konieczka, Seita Morishita, Taeko Horie, Tsunehiko Ikeda
Retinal vein occlusion (RVO) is a common vascular disease of the retina; however, the pathogenesis of RVO is still unclear. Branch RVO (BRVO) commonly occurs at the arteriovenous crossing and it was formerly believed that the diseased artery mechanically compresses the vein. However, it has been reported that the retinal vein runs deep beneath the artery at the arteriovenous crossing in eyes with an arterial overcrossing, and the venous lumen often appears to be preserved, even at the arteriovenous crossing, as shown by optical coherence tomography...
December 2018: Data in Brief
Dominik Schuler, Roberto Sansone, Christopher Nicolaus, Malte Kelm, Christian Heiss
OBJECTIVE: Collateral expansion is an important compensatory mechanism to alleviate tissue ischemia after arterial occlusion. We investigated the efficacy and mechanisms of temporary remote hindlimb occlusion to stimulate contralateral blood flow and collateral expansion after hindlimb ischemia in mice and evaluated translation to peripheral artery disease in humans. METHODS AND RESULTS: We induced unilateral hindlimb ischemia via femoral artery excision in mice...
October 15, 2018: Free Radical Biology & Medicine
Michał Elwertowski, Jerzy Leszczyński, Piotr Kaszczewski, Krzysztof Lamparski, Stella Sin Yee Ho, Zbigniew Gałązka
AIM: An assessment of increased compensatory blood flow in the brain-supplying arteries in patients with significant carotid artery stenosis. MATERIALS AND METHODS: Doppler ultrasound was performed in 218 patients over 60 years of age to evaluate both the degree of brain-supplying artery stenosis as well as the blood flow volume balance in all vessels supplying the brain: the internal carotid artery, the external carotid artery and the vertebral artery. The control group included 94 patients with no stenosis in the extracranial segments and no neurological manifestations, in whom blood flow values were calculated (the internal carotid artery - 290 mL/min, the external carotid artery - 125 mL/min, the vertebral artery - 80 mL/min); the total mean blood flow in the brain-supplying arteries was 985 mL/min...
2018: Journal of Ultrasonography
Lotfi Hacein-Bey, Jeremy J Heit, Angelos A Konstas
Restoration of cerebral blood flow is the most important step in preventing irreversible damage to hypoperfused brain cells after ischemic stroke from large-vessel occlusion. For those patients who do not respond to (or are not eligible for) intravenous thrombolysis, endovascular therapy has become standard of care. A shift is currently taking place from rigid time windows for intervention (time is brain) to physiology-driven paradigms that rely heavily on neuroimaging. At this time, one can reasonably anticipate that more patients will be treated, and that outcomes will keep improving...
November 2018: Neuroimaging Clinics of North America
Jeremy J Heit, Greg Zaharchuk, Max Wintermark
Acute ischemic stroke (AIS) occurs when there is a sudden loss in cerebral blood flow due to embolic or thromboembolic occlusion of a cerebral or cervical artery. Patients with AIS require emergent neuroimaging to guide treatment, which includes intravenous thrombolysis and endovascular mechanical thrombectomy (EMT). Recent advances in AIS treatment by EMT has been driven in part by advances in computed tomography (CT) and MR imaging neuroimaging evaluation of ischemic penumbra and pial collateral vessels. The authors review advanced noninvasive brain imaging by CT and MR imaging for the evaluation of AIS focusing on penumbral and collateral imaging...
November 2018: Neuroimaging Clinics of North America
V V Bazylev, E V Nemchenko, A I Mikuliak, V A Karnakhin
The purpose of the study was to analyse the remote results of bypass grafting for myocardial bridges. Our retrospective single-centre study included a total of 17 patients subjected to coronary bypass grafting of the anterior descending artery (ADA) in connection with a detected myocardial bridge (MB). All patients underwent assessment of the coronary bypass grafts (CBG) by means of intraoperative flowmetry - transit time flow measurement (TTFM), as well as angiographic control of the CBGs in the remote period...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Ivana Rajkovic, Raymond Wong, Eloise Lemarchand, Jack Rivers-Auty, Olivera Rajkovic, Cecilia Garlanda, Stuart M Allan, Emmanuel Pinteaux
Restoration of cerebral blood flow (CBF) and upregulation of angiogenesis are crucial for brain repair and functional recovery after cerebral ischaemia. Pentraxin 3 (PTX3) is a key regulator of angiogenesis and is emerging as a promising target for cerebrovascular repair after stroke. Here, we investigated for the first time the role of PTX3 in long-term CBF, angiogenesis, and neuronal viability after ischaemic stroke induced by transient middle cerebral artery occlusion (MCAo). Lack of PTX3 had no effect on early brain damage, but significantly impaired restoration of CBF, 14 and 28 days after MCAo, compared to wild-type (WT) mice...
October 13, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Kohsuke Kakumoto, Kei Harada, Yukihiro Sankoda, Syunsuke Taniguchi, Kouzou Fukuyama
Carotid artery stenting (CAS) with proximal protection can expose occlusion intolerance (OI) due to ipsilateral cerebral hemisphere hypoperfusion. Near-infrared spectroscopy (NIRS) cerebral oximetry can monitor regional cerebral oxygenation (rSO2 ) in the frontal lobes, and is used during CAS to predict cerebral blood flow insufficiency. The aim of this study was to evaluate rSO2 as a predictor of OI during CAS. We retrospectively examined 146 patients who underwent CAS with proximal protection. An INVOS® NIRS oximeter was used for rSO2 measurement, which was compared with stump pressure (SP) measured by a guiding catheter during occlusion of the common carotid artery (CCA) and external carotid artery...
October 9, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Myung Rae Cho, Kyung Tae Kim, Won Kee Choi
RATIONALE: Arterial occlusion, a rare condition after total knee arthroplasty (TKA), may cause fatal outcomes if not treated on time. We report a case of arterial occlusion after undergoing navigated TKA with no tourniquet use, in a patient at high risk of postoperative arterial occlusion due to the patient's ipsilateral popliteal artery aneurysm. PATIENTS CONCERNS: A 79-year-old man presented with several years of left knee joint pain. Nine years earlier, the patient underwent vascular graft surgery on his right knee due to occlusion in his right popliteal artery...
October 2018: Medicine (Baltimore)
Renan S Guerra, Thiago T Goya, Rosyvaldo F Silva, Marta F Lima, Eline R F Barbosa, Maria Janieire de N N Alves, Amanda G Rodrigues, Geraldo Lorenzi-Filho, Carlos Eduardo Negrão, Linda M Ueno-Pardi
We demonstrated that patients with obstructive sleep apnea (OSA) have reduced muscle metaboreflex control of muscle sympathetic nerve activity (MSNA). Additionally, exercise training increased muscle metaboreflex control in heart failure patients. OBJECTIVE: We tested the hypothesis that exercise training would increase muscle metaboreflex control of MSNA in patients with OSA. METHODS: Forty-one patients with OSA were randomized into the following two groups: (1) nontrained (OSANT, n=21) and (2) trained (OSAT, n=20)...
October 11, 2018: Medicine and Science in Sports and Exercise
Fehmi Kacmaz, Adnan Kaya, Muhammed Keskin, Serdar Keceoglu, Ibrahim Halil Algin, Bayram Yilmazkaya, Erdogan Ilkay
Objective Buerger's disease is one of the worst diseases causing peripheral artery occlusions (especially lower extremity) with increased morbidity and mortality. Endovascular treatment of the diseased arteries gains preference over bypass surgery nowadays. Here, we aimed to present the clinical outcomes of 16 consecutive Buerger's disease patients underwent extended endovascular recanalization which is a new technique to restore direct blood flow to at least one foot artery, with the performance of angioplasty for each tibial and foot artery obstructions...
October 10, 2018: Vascular
Francesca Di Giuliano, Eliseo Picchi, Fabrizio Sallustio, Valentina Ferrazzoli, Fana Alemseged, Laura Greco, Silvia Minosse, Valerio Da Ros, Marina Diomedi, Francesco Garaci, Simone Marziali, Roberto Floris
Background and purpose Computed tomography perfusion (CTP) and multiphase CT angiography (mCTA) help selection for endovascular treatment (EVT) in anterior ischemic stroke (AIS). Our aim was to investigate the ability of perfusion maps and collateral score to predict functional outcome after EVT. Patients and methods Patients with M1-middle cerebral artery occlusion, evaluated by mCTA and CTP and treated with EVT within six hours of onset, were enrolled. Perfusion parametric maps of cerebral blood flow (CBF), cerebral blood volume (CBV) and time to maximum of tissue residue function ( Tmax ) were generated; areas of altered perfusion were manually outlined to obtain volumes CBFv , CBVv , [Formula: see text] and [Formula: see text]...
October 10, 2018: Neuroradiology Journal
Jan Bucerius, Ingrid Dijkgraaf, Felix M Mottaghy, Leon J Schurgers
Cardiovascular disease is the major cause of morbidity and mortality in developed countries and atherosclerosis is the major cause of cardiovascular disease. Atherosclerotic lesions obstruct blood flow in the arterial vessel wall and can rupture leading to the formation of occlusive thrombi. Conventional diagnostic tools are still of limited value for identifying the vulnerable arterial plaque and for predicting its risk of rupture and of releasing thromboembolic material. Knowledge of the molecular and biological processes implicated in the process of atherosclerosis will advance the development of imaging probes to differentiate the vulnerable plaque...
October 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Mitra Sadeghi, Tal M Hörer, Daniel Forsman, Emanuel M Dogan, Kjell Jansson, Csaba Kindler, Per Skoog, Kristofer F Nilsson
BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective adjunct in exsanguinating torso hemorrhage, but causes ischemic injury to distal organs. The aim was to investigate whether blood pressure targeting by partial REBOA (pREBOA) is possible in porcine severe hemorrhagic shock and to compare pREBOA and total REBOA (tREBOA) regarding hemodynamic, metabolic and inflammatory effects. METHODS: Eighteen anesthetized pigs were exposed to induced controlled hemorrhage to a systolic blood pressure (SBP) of 50 mmHg and randomized into three groups of thoracic REBOA: 30 min of pREBOA (target SBP 80-100 mmHg), tREBOA, and control...
September 29, 2018: Injury
Samuel Ademola Adegoke, Bankole Peter Kuti, Kehinde Oluyori Omole, Olufemi Samuel Smith, Oyeku Akibu Oyelami, Oluwagbemiga Oyewole Adeodu
BACKGROUND: Sickle cell anaemia (SCA) is a chronic inflammatory disorder with multiple organ manifestations including acute and long-term pulmonary dysfunction. AIMS/OBJECTIVES: To assess lung function of children with SCA and determine the possible role of acute chest syndrome (ACS), serum inflammatory cytokines, highly sensitive C-reactive protein (hs-CRP), leucocytes and 25-hydroxyvitamin D on the development of impaired lung function. SUBJECTS AND METHODS: Lung function of 76 children with SCA was determined by spirometer and classified into normal or impaired...
October 8, 2018: Paediatrics and International Child Health
Sarah J Willis, Laurent Alvarez, Fabio Borrani, Grégoire P Millet
The aim was to evaluate changes in peripheral and cerebral oxygenation, cardiorespiratory, and performance differences, as well as neuromuscular fatigue across multiple levels of blood flow restriction (BFR) during a repeated cycling sprint test to exhaustion (RST). Participants performed three RST (10-sec maximal sprints with 20-sec recovery until exhaustion) with measurements of power output and V̇O2peak as well as oxygenation (near-infrared spectroscopy) of the vastus lateralis and prefrontal cortex. Neuromuscular fatigue was assessed by femoral nerve stimulation to evoke the vastus lateralis...
September 2018: Physiological Reports
Yuan-Hsiung Tsai, Jenq-Lin Yang, I-Neng Lee, Jen-Tsung Yang, Leng-Chieh Lin, Yen-Chu Huang, Mei-Yu Yeh, Hsu-Huei Weng, Chia-Hao Su
Background: Dehydration is common among ischemic stroke patients and is associated with early neurological deterioration and poor outcome. This study aimed to test the hypothesis that dehydration status is associated with decreased cerebral perfusion and aggravation of ischemic brain injury. Methods: Diffusion-weighted imaging and arterial spin labeling perfusion MR imaging were performed on rats with middle cerebral artery occlusion (MCAO) by using a 9.4T MR imaging scanner to measure the volume of infarction and relative cerebral blood flow (rCBF) after infarction...
2018: Frontiers in Neurology
Samuel G Thorpe, Corey M Thibeault, Seth J Wilk, Michael O'Brien, Nicolas Canac, Mina Ranjbaran, Christian Devlin, Thomas Devlin, Robert B Hamilton
Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large vessel occlusion (LVO) represents a first critical step toward enabling use by less formally trained personnel. In this work, we assess the diagnostic utility, relative to current standard CT angiography (CTA), of a novel TCD-derived biomarker for detecting LVO...
October 6, 2018: Translational Stroke Research
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