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https://www.readbyqxmd.com/read/30537643/molecular-docking-molecular-dynamics-simulations-and-qsar-studies-on-some-of-2-arylethenylquinoline-derivatives-for-inhibition-of-alzheimer-s-amyloid-beta-aggregation-insight-into-mechanism-of-interactions-and-parameters-for-design-of-new-inhibitors
#1
Hossein Safarizadeh, Zahra Garkani-Nejad
Alzheimer's disease is characterized using amyloid-beta (Aβ) aggregation. The present work was carried out to extend and design a novel quantitative structure-activity relationship (QSAR) model on inhibition efficiency of some of new 2-arylethenylquinoline derivatives against the Aβ1-42 peptide aggregation. The QSAR study, molecular docking and molecular dynamics (MD) simulations were performed to explore the influence of the structural features and investigate the molecular mechanism of ligands interactions with the Aβ1-42 peptide...
December 4, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/30536873/ready-to-use-thermally-stable-mastermix-pills-for-molecular-biology-applications
#2
Vincent Leung, Meredith Brooks, Sophia Emerson, M Monsur Ali, Carlos D M Filipe
Rolling circle amplification (RCA), polymerase chain reaction (PCR), and loop-mediated isothermal amplification (LAMP), are powerful tools that can be used for gene manipulation, pathogen detection, and infectious disease diagnostics. However, these techniques require trained personnel, as the pipetting steps involved can lead to contamination and, consequently, erroneous results. Furthermore, many of the reagents used in molecular biology are thermally labile and must be kept within a cold-chain. In this paper, we present a simple and cost-effective method that allows molecular biology reagents to be thermally stabilized into ready-to-use mastermixes via drying in pullulan and trehalose films...
December 8, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/30536668/cross-infection-control-in-clinical-training-development-of-a-device-for-storing-a-composite-resin-in-restorative-dentistry
#3
Ana Luísa Botta Martins de Oliveira, Danielle Wajngarten, Cristina Dupim Presoto, Hélida Gomes de Oliveira Barud, Rafael Romano Domeneguetti, Ana Carolina Botta, Patricia Petromilli Nordi Sasso Garcia
This study presented a biosafety device for the hygienic storage of composite resin during restorative procedures in teaching clinics, RESTAURASAFE, and to compare the color stability, surface hardness, and degree of conversion of the composite resin made with the proposed device to those of conventionally made resins. Esthet-X HD composite was manipulated directly from the syringe, fractionated doses, dappen dish or RESTAURASAFE. Disc-shaped specimens were immersed in artificial saliva and coffee for 60 days and the color stability and the Vickers surface hardness were evaluated during 60 days...
October 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/30535030/en-route-resuscitation-utilization-of-ccatt-to-transport-and-stabilize-critically-injured-and-unstable-casualties
#4
Joseph K Maddry, Eric M Ball, Daniel B Cox, Kathleen M Flarity, Vikhyat S Bebarta
Introduction: The U.S. Air Force utilizes specialized Critical Care Air Transport Teams (CCATT) for transporting "stabilized" patients. Given the drawdown of military forces from various areas of operation, recent CCATT operations have increasingly involved the evacuation of unstable and incompletely resuscitated patients from far forward, austere locations. This brief report describes unique cases representative of the evolving CCATT mission and provides future direction for changes in doctrine and educational requirements in preparation for en route combat casualty care...
December 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/30534617/effects-of-triple-treatment-trunk-stretching-on-physical-fitness-and-curvature-of-the-spine
#5
Koichi Wakimoto, Toshifumi Dakeshita, Junichi Wakimoto, Toshiaki Watanabe, Saiki Terasawa, Masao Okuhara, Yuki Murata, Naoya Taki, Ryoji Uchiyama, Kazuki Ashida, Suchinda Jarupat Maruo, Koji Terasawa
Background: Research on the effectiveness of treatment for low back disorders has been made, however yet no established method has been found. Therefore, we devised a triple-treatment trunk stretching program comprising the following three trunk stretching exercises: stretching using an unstable flex chair; stretching using a stretching bench; and stretching using a stretch pad. Our three-treatment trunk stretching program is based on the principles of static muscular stabilization of the spine and uses well-known physiological strength-training principles...
December 2018: Heliyon
https://www.readbyqxmd.com/read/30534189/muscular-imbalances-and-balance-capability-in-dance
#6
Eileen M Wanke, Julia Schreiter, David A Groneberg, Burkhard Weisser
Objective: A high unilateral load to the musculoskeletal system is specific for formation dance. Due to the lack of data the aim of this study was the side-related (right - left) analysis of strength- and balance capability subject to injuries, gender and performance standards. Methods: N  = 51 dancers (m: n  = 24, f: m = 27) of two performance levels participated in this cross-sectional study. Double-sided tests of the isometric maximal strength of relevant muscle groups and the balance capability were carried out...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/30530767/global-dynamics-of-bipedal-macaques-during-grounded-and-aerial-running
#7
Reinhard Blickhan, Emanuel Andrada, Eishi Hirasaki, Naomichi Ogihara
Macaques trained to perform bipedally use grounded running, skipping and aerial running, but avoid walking. The preference for grounded running across a wide range of speeds is substantially different from the locomotion habits observed in humans, which may be the result of differences in leg compliance. In the present study, based on kinematic and dynamic observations of three individuals crossing an experimental track, we investigated global leg properties such as leg stiffness and viscous damping during grounded and aerial running...
December 10, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/30526235/landing-kinematics-sports-performance-and-isokinetic-strength-in-adolescent-male-volleyball-athletes-influence-of-core-training
#8
Yi-Ju Tsai, Chieh-Chie Chia, Pei-Yun Lee, Li-Chuan Lin, Yi-Liang Kuo
CONTEXT: Core control and strength are important for reducing the risk of lower extremity injury. Current evidence on the effect of core training in male adolescent athletes is limited, and other investigations into the effects of core training often emphasized core strength only. OBJECTIVE: To examine whether core training emphasizing both control and strength of the trunk and hip would improve joint kinematics during landing, sports performance, and lower extremity muscle strength in adolescent male volleyball athletes...
December 11, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/30526226/exercising-on-different-unstable-surfaces-increases-core-abdominal-muscle-thickness-an-observational-study-using-real-time-ultrasound
#9
Timothy J Gibbons, Marie-Louise Bird
BACKGROUND: The training of abdominal muscles has a positive impact on the functional capacity of healthy adults, being applied practically in fields of athletics and fitness through to rehabilitation for lower back pain. OBJECTIVE: The study compares abdominal muscle activity while performing graded isometric exercises on stable and unstable surfaces. We also examined perceived stability and comfort for the different surfaces. METHODS: Thirty young, healthy adults performed three graded, isometric exercises on a Pilates table, foam roller and Oov (a newly developed tool)...
December 11, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/30524633/effects-of-massage-as-a-combination-therapy-with-lumbopelvic-stability-exercises-as-compared-to-standard-massage-therapy-in-low-back-pain-a-randomized-cross-over-study
#10
Leonard H Joseph, Benjamaporn Hancharoenkul, Patraporn Sitilertpisan, Ubon Pirunsan, Aatit Paungmali
Background: Little is known about the effects of providing massage as a combination therapy (CT) with lumbopelvic stability training (LPST) in management of chronic nonspecific low back pain (CLBP) among elite female weight lifters. It is unclear whether massage therapy (MT) together with LPST has any additional clinical benefits for individuals with CLBP. Purpose: The current study compares the therapeutic effects of CT against MT as a stand-alone intervention on pain intensity (PI), pain pressure threshold (PPT), tissue blood flow (TBF), and lumbopelvic stability (LPS) among elite weight lifters with CLBP...
December 2018: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/30524356/gait-stability-training-in-a-virtual-environment-improves-gait-and-dynamic-balance-capacity-in-incomplete-spinal-cord-injury-patients
#11
Rosanne B van Dijsseldonk, Lysanne A F de Jong, Brenda E Groen, Marije Vos-van der Hulst, Alexander C H Geurts, Noel L W Keijsers
Many patients with incomplete spinal cord injury (iSCI) have impaired gait and balance capacity, which may impact daily functioning. Reduced walking speed and impaired gait stability are considered important underlying factors for reduced daily functioning. With conventional therapy, patients are limited in training gait stability, but this can be trained on a treadmill in a virtual environment, such as with the Gait Real-time Analysis Interactive Lab (GRAIL). Our objective was to evaluate the effect of 6-weeks GRAIL-training on gait and dynamic balance in ambulatory iSCI patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30523747/local-dynamic-stability-of-the-locomotion-of-lower-extremity-joints-and-trunk-during-backward-upslope-walking
#12
Yu Wu, Anmin Liu, Ke-Rong Dai, Dong-Yun Gu
Backward slope walking was considered as a practical rehabilitation and training skill. However, its gait stability has been hardly studied, resulting in its limited application as a rehabilitation tool. In this study, the effect of walking direction and slope grade were investigated on the local dynamic stability of the motion of lower extremity joints and trunk segment during backward and forward upslope walking (BUW/FUW). The local divergence exponents (λS ) of 16 adults were calculated during their BUW and FUW at grades of 0%, 5%, 10%, and 15%...
December 7, 2018: Journal of Motor Behavior
https://www.readbyqxmd.com/read/30517171/training-intensity-quantification-of-core-stability-exercises-based-on-a-smartphone-accelerometer
#13
David Barbado, Belen Irles-Vidal, Amaya Prat-Luri, María Pilar García-Vaquero, Francisco J Vera-Garcia
Although core stability (CS) training is largely used to enhance motor performance and prevent musculoskeletal injuries, the lack of methods to quantify CS training intensity hinders the design of CS programs and the comparison and generalization of their effects. The aim of this study was to analyze the reliability of accelerometers integrated into smartphones to quantify the intensity of several CS isometric exercises. Additionally, this study analyzed to what extent the pelvic acceleration data represent the local stability of the core structures or the whole-body postural control...
2018: PloS One
https://www.readbyqxmd.com/read/30516635/the-critical-portions-of-carpal-tunnel-release-ulnar-nerve-transposition-and-open-reduction-and-internal-fixation-of-the-distal-part-of-the-radius
#14
Christopher J Dy, Alison L Antes, Daniel A Osei, Charles A Goldfarb, James M DuBois
BACKGROUND: Overlapping surgery is attracting increased scrutiny. The American College of Surgeons states that the attending surgeon must be present for all critical portions of a surgical procedure; however, critical portions of surgical procedures are not defined. We hypothesized that a Delphi panel process would measure consensus on critical portions of 3 common hand surgical procedures. METHODS: We used a Delphi process to achieve consensus on the critical portions of carpal tunnel release, ulnar nerve transposition, and open reduction and internal fixation of the distal part of the radius...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30510419/nanodelivery-systems-and-stabilized-solid-drug-nanoparticles-for-orally-administered-medicine-current-landscape
#15
REVIEW
Ali Kermanizadeh, Leagh G Powell, Vicki Stone, Peter Møller
The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30510304/a-new-long-lived-jupiter-mesoscale-wave-observed-at-visible-wavelengths
#16
Amy A Simon, Ricardo Hueso, Peio Iñurrigarro, Agustín Sánchez-Lavega, Raúl MoralesJuberías, Richard Cosentino, Leigh N Fletcher, Michael H Wong, Andrew I Hsu, Imke de Pater, Glenn S Orton, François Colas, Marc Delcroix, Damian Peach, Josep-María Gómez-Forrellad
Small-scale waves were observed along the boundary between Jupiter's North Equatorial Belt and North Tropical Zone, ~16.5° N planetographic latitude in Hubble Space Telescope data in 2012 and throughout 2015 to 2018, observable at all wavelengths from the UV to the near IR. At peak visibility, the waves have sufficient contrast (~10%) to be observed from ground-based telescopes. They have a typical wavelength of about 1.2° (1400 km), variable-length wave trains, and westward phase speeds of a few m/s or less...
August 2018: Astronomical Journal
https://www.readbyqxmd.com/read/30508498/predictors-of-clinical-success-with-stabilization-exercise-are-associated-with-lower-levels-of-lumbar-multifidus-intramuscular-adipose-tissue-in-patients-with-low-back-pain
#17
Jeffrey J Hebert, Edward C Le Cara, Shane L Koppenhaver, Martin D Hoffman, Robin L Marcus, Alasdair R Dempsey, Wayne J Albert
PURPOSE: Investigate the construct validity of prognostic factors purported to predict clinical success with stabilization exercise for low back pain by exploring their associations with lumbar multifidus composition. METHODS: Patients with low back pain were recruited from a hospital imaging department. The presence of fivepredictors (age <40 years, positive prone instability test, aberrant trunk flexion movements, straight leg raise range of motion >91°, spinal hypermobility) were identified by standardized physical examination...
December 3, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/30507832/can-an-augmented-reality-headset-improve-accuracy-of-acetabular-cup-orientation-in-simulated-tha-a-randomized-trial
#18
Kartik Logishetty, Luke Western, Ruairidh Morgan, Farhad Iranpour, Justin P Cobb, Edouard Auvinet
BACKGROUND: Accurate implant orientation reduces wear and increases stability in arthroplasty but is a technically demanding skill. Augmented reality (AR) headsets overlay digital information on top of the real world. We have developed an enhanced AR headset capable of tracking bony anatomy in relation to an implant, but it has not yet been assessed for its suitability as a training tool for implant orientation. QUESTIONS/PURPOSES: (1) In the setting of simulated THA performed by novices, does an AR headset improve the accuracy of acetabular component positioning compared with hands-on training by an expert surgeon? (2) What are trainees' perceptions of the AR headset in terms of realism of the task, acceptability of the technology, and its potential role for surgical training? METHODS: Twenty-four study participants (medical students in their final year of school, who were applying to surgery residency programs, and who had no prior arthroplasty experience) participated in a randomized simulation trial using an AR headset and a simulated THA...
November 29, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/30507533/deep-online-video-stabilization-with-multi-grid-warping-transformation-learning
#19
Miao Wang, Guo-Ye Yang, Jin-Kun Lin, Song-Hai Zhang, Ariel Shamir, Shao-Ping Lu, Shi-Min Hu
Video stabilization techniques are essential for most hand-held captured videos due to high-frequency shakes. Several 2D, 2.5D and 3D-based stabilization techniques have been presented previously, but to our knowledge, no solutions based on deep neural networks had been proposed to date. The main reason for this omission is shortage in training data as well as the challenge of modeling the problem using neural networks. In this paper, we present a video stabilization technique using a convolutional neural network...
November 30, 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/30506461/intervertebral-disc-herniation-in-elite-athletes
#20
REVIEW
Jonathan T Yamaguchi, Wellington K Hsu
Intervertebral disc herniations are a common cause of neck and back pain in athletes. It is thought to be more prevalent in athletes than in the general population due to the consistent pressure placed on the spine and concurrent microtraumas that are unable to heal. Prevention focuses on neck and trunk stability and flexibility, training on proper technique, and rule changes to minimize catastrophic injuries. The evaluation for athletes includes a full neurologic exam and imaging. The imaging modality of choice is MRI, but CT myelography can be a useful alternative...
December 1, 2018: International Orthopaedics
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