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Fukashi Ishibashi, Mitra Tavakoli
Aims: Hyperglycemia is associated with an increased risk of microvascular complications in patients with type 2 diabetes. The aim of the present study was to investigate whether the reduction of the levels of HbA1c by tight glycemic control (GC) decreases the rate of microvascular complications and improves the neurological measures in patients with type 2 diabetes. Methods: Detailed clinical and neurological examinations including corneal confocal microscopy (CCM) were performed in 141 Japanese patients with type 2 diabetes and 60 age-matched control subjects at baseline and follow-up with GC for 4 years...
2018: Frontiers in Endocrinology
E K Yeoh, Martin C S Wong, Eliza L Y Wong, Carrie Yam, C M Poon, Roger Y Chung, Marc Chong, Yuan Fang, Harry H X Wang, Miaoyin Liang, Wilson W L Cheung, Chun Hei Chan, Benny Zee, Andrew J Stewart Coats
BACKGROUND: Chronic Care Model (CCM) has been developed to improve patients' health care by restructuring health systems in a multidimensional manner. This systematic review aims to summarize and analyse programs specifically designed and conducted for the fulfilment of multiple CCM components. We have focused on programs targeting diabetes mellitus, hypertension and cardiovascular disease. METHOD AND RESULTS: This review was based on a comprehensive literature search of articles in the PubMed database that reported clinical outcomes...
May 1, 2018: International Journal of Cardiology
Líliam Barbosa Silva, Sônia Maria Soares, Patrícia Aparecida Barbosa Silva, Joseph Fabiano Guimarães Santos, Lívia Carvalho Viana Miranda, Raquel Melgaço Santos
OBJECTIVE: to evaluate the quality of care provided to older people with diabetes mellitus and/or hypertension in the Primary Health Care (PHC) according to the Chronic Care Model (CCM) and identify associations with care outcomes. METHOD: cross-sectional study involving 105 older people with diabetes mellitus and/or hypertension. The Patient Assessment of Chronic Illness Care (PACIC) questionnaire was used to evaluate the quality of care. The total score was compared with care outcomes that included biochemical parameters, body mass index, pressure levels and quality of life...
March 8, 2018: Revista Latino-americana de Enfermagem
Rangarirai Matima, Katherine Murphy, Naomi S Levitt, Rhonda BeLue, Tolu Oni
BACKGROUND: Current South African health policy for chronic disease management proposes integration of chronic services for better outcomes for chronic conditions; that is based on the Integrated Chronic Disease Model (ICDM). However, scant data exist on how patients with chronic multimorbidities currently experience the (re)-organisation of health services and what their perceived needs are in order to enhance the management of their conditions. METHODS: A qualitative study was conducted in a community health centre treating both HIV and diabetes patients in Cape Town...
2018: PloS One
F Wang, D N Feng, Y Liu, Z Liu, T Sun
Objective: To evaluate the efficacy and safety of microsurgical in the treatment of temporal lobe cerebral cavernous malformation (CCM) with epilepsy. Methods: Temporal lobe CCM patients with epilepsy admitted to our department were collected from January 2010 to September 2016. Locations of the CCM were divided into (1) lateral-lateral to the collateral sulcus; (2) mesial-mesial to the collateral sulcus. In the lateral group, patients were underwent intraoperative electrocorticography (ECoG)-guided resection of lesion and hemosiderin rim...
March 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
G A Mejicanos, J W Kim, C M Nyachoti
Tail-end dehulling of canola meal (CM) has been shown to reduce dietary fiber and increase crude protein content in the dehulled meal. The application of this procedure also increased the total and non-phytate P content in the dehulled meal. However, it is unclear if dehulling affects P digestibility in the different fractions (i.e., the dehulled meal and the coarse fraction) and if it differs when fed to growing pigs at 2 different BW. Therefore, 2 experiments were conducted to determine the apparent (ATTD) and standardized (STTD) total tract digestibility of P in dehulled CM fed to growing pigs...
February 24, 2018: Journal of Animal Science
Sanjeev Sharma, Victoria Tobin, Prashanth R J Vas, Rayaz A Malik, Gerry Rayman
INTRODUCTION: The laser Doppler imaging (LDI) FLARE and corneal confocal microscopy (CCM) are reliable markers of small fibre function (SFF) and structure (SFS), respectively, but the impact of potential confounding variables needs to be defined. The objective of this study was to determine the influence of age, anthropometric and biochemical variables on LDI and CCM. METHODS: 80 healthy volunteers (43 males) (age: 39.7±15.2 yrs.) underwent LDIFLARE and CCM assessment and the effect of age, anthropometric and biochemical variables was determined using multivariate analysis...
2018: PloS One
Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Andrea Perrelli, Claudia Fornelli, Francesca Retta, Paola Cassoni, Vincenzo Nicola Talesa, Saverio Francesco Retta
This article contains additional data related to the original research article entitled "KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: implication for Cerebral Cavernous Malformation disease" (Antognelli et al., 2017) [1]. Data were obtained by si-RNA-mediated gene silencing, qRT-PCR, immunoblotting, and immunohistochemistry studies, and enzymatic activity and apoptosis assays. Overall, they support, complement and extend original findings demonstrating that KRIT1 loss-of-function induces a redox-sensitive and JNK-dependent sustained upregulation of the master Nrf2 antioxidant defense pathway and its downstream target Glyoxalase 1 (Glo1), and a drop in intracellular levels of AP-modified Hsp70 and Hsp27 proteins, leading to a chronic adaptive redox homeostasis that sensitizes cells to oxidative DNA damage and apoptosis...
February 2018: Data in Brief
Jim C H Wilde, Ana M Calinescu, Barbara E Wildhaber
Biliary atresia (BA) and congenital choledochal malformations (CCM) are rare. Both pathologies must (BA) or may (CCM) be operated during the neonatal period or early infancy. We briefly describe the classical operative techniques for both pathologies, followed by the most common and severe perioperative complications encountered during and up to 30 days after surgery in children operated for BA and CCM early in life. For patients with BA, intestinal complications represent the most common and hazardous perioperative surgical complications...
March 6, 2018: European Journal of Pediatric Surgery
Laura K Winn, Adriane Lesser, Diana Menya, Joy N Baumgartner, Joseph Kipkoech Kirui, Indrani Saran, Wendy Prudhomme-O'Meara
Background: The continued success of community case management (CCM) programs in low-resource settings depends on the ability of these programs to retain the community health workers (CHWs), many of whom are volunteers, and maintain their high-quality performance. This study aims to identify factors related to the motivation and satisfaction of CHWs working in a malaria CCM program in two sub-counties in Western Kenya. Methods: We interviewed 70 CHWs who were trained to administer malaria rapid diagnostic tests as part of a broader study evaluating a malaria CCM program...
June 2018: Journal of Global Health
Tobias Busche, Renata Novakova, Arwa Al'Dilaimi, Dagmar Homerova, Lubomira Feckova, Bronislava Rezuchova, Erik Mingyar, Dominika Csolleiova, Carmen Bekeova, Anika Winkler, Beatrica Sevcikova, Jörn Kalinowski, Jan Kormanec, Christian Rückert
Streptomyces lavendulae subsp. lavendulae CCM 3239 produces the angucycline antibiotic auricin and was thought to be the type strain of Streptomyces aureofaciens We report the complete genome sequence of this strain, which consists of a linear chromosome and the linear plasmid pSA3239, and demonstrate it to be S. lavendulae subsp. lavendulae .
March 1, 2018: Genome Announcements
Xin Chen, Jim Graham, Ioannis N Petropoulos, Georgios Ponirakis, Omar Asghar, Uazman Alam, Andrew Marshall, Maryam Ferdousi, Shazli Azmi, Nathan Efron, Rayaz A Malik
Objective: Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a noninvasive and objective imaging biomarker for identifying small nerve fiber damage. We have evaluated the diagnostic performance of previously established CCM parameters to a novel automated measure of corneal nerve complexity called the corneal nerve fiber fractal dimension (ACNFrD). Methods: A total of 176 subjects (84 controls and 92 patients with type 1 diabetes) with and without diabetic sensorimotor polyneuropathy (DSPN) underwent CCM...
February 1, 2018: Investigative Ophthalmology & Visual Science
Tua Hakanpää, Teija Waaramaa, Anne-Maria Laukkanen
OBJECTIVES: This study examines the recognition of emotion in contemporary commercial music (CCM) and classical styles of singing. This information may be useful in improving the training of interpretation in singing. STUDY DESIGN: This is an experimental comparative study. METHODS: Thirteen singers (11 female, 2 male) with a minimum of 3 years' professional-level singing studies (in CCM or classical technique or both) participated. They sang at three pitches (females: a, e1, a1, males: one octave lower) expressing anger, sadness, joy, tenderness, and a neutral state...
February 22, 2018: Journal of Voice: Official Journal of the Voice Foundation
Peter Kämpfer, Hans-Jürgen Busse, Sophie Baars, Gottfried Wilharm, Stefanie P Glaeser
A beige-pigmented bacterial strain, SB30-Chr27-3T , isolated from a garden pond, was studied for its taxonomic position. Cells of the isolate were rod-shaped and stained Gram-negative. A comparison of the 16S rRNA gene sequence with the sequences of the type strains of the most closely related species showed that the strain belongs to the genus Comamonas and showed highest sequence similarities to the type strains of Comamonas jiangduensis (97.5 %), Comamonas aquatica (97.4 %) and Comamonas phosphati (97...
February 23, 2018: International Journal of Systematic and Evolutionary Microbiology
Christine Brückner, Mislav Oreb, Gotthard Kunze, Eckhard Boles, Joanna Tripp
A wide range of commercially relevant aromatic chemicals can be synthesized via the shikimic acid pathway. Thus, this pathway has been the target of diverse metabolic engineering strategies. In the present work, an optimized yeast strain for production of the shikimic acid pathway intermediate 3-dehydroshikimate (3-DHS) was generated, which is a precursor for the production of the valuable compounds cis, cis-muconic acid (CCM) and gallic acid (GA). Production of CCM requires the overexpression of the heterologous enzymes 3-DHS dehydratase AroZ, protocatechuic acid (PCA) decarboxylase AroY and catechol dioxygenase CatA...
February 15, 2018: FEMS Yeast Research
Alise Kalteniece, Maryam Ferdousi, Ioannis Petropoulos, Shazli Azmi, Safwaan Adam, Hassan Fadavi, Andrew Marshall, Andrew J M Boulton, Nathan Efron, Catharina G Faber, Giuseppe Lauria, Handrean Soran, Rayaz A Malik
We assessed whether a measure of more distal corneal nerve fibre loss at the inferior whorl(IW) region is better than proximal measures of central corneal nerve damage in relation to the diagnosis of diabetic peripheral neuropathy(DPN), painful DPN and quality of life(QoL). Participants underwent detailed assessment of neuropathy, QoL using the SF36 questionnaire, pain visual analogue score(VAS), and corneal confocal microscopy(CCM). Corneal nerve fibre density (CNFD), branch density (CNBD) and length (CNFL) at the central cornea and inferior whorl length (IWL) and average(ANFL) and total(TNFL) nerve fibre length were compared in patients with and without DPN and between patients with and without painful DPN and in relation to QoL...
February 19, 2018: Scientific Reports
Peter Kämpfer, P D Rekha, Hans-Jürgen Busse, A B Arun, P Priyanka, Stefanie P Glaeser
A Gram-stain-negative, aerobic, non-endospore-forming organism, isolated from the rhizosphere sand of a coastal sand dune plant was studied for its taxonomic position. On the basis of 16S rRNA gene sequence similarity comparisons, strain YU-PRIM-29T was grouped within the genus Halomonas and was most closely related to Halomonas johnsoniae (97.5 %). The 16S rRNA gene sequence similarity to other Halomonas species was <97.5 %. Strain YU-PRIM-29T grew optimally at 28 °C (growth range, 10-36 °C), at a pH of 7-9 (growth range, pH 5...
February 12, 2018: International Journal of Systematic and Evolutionary Microbiology
Peter Kämpfer, Hans-Jürgen Busse, Stefanie P Glaeser
A Gram-stain-positive, aerobic, endospore-forming bacterium isolated from a coolant lubricant was studied for its taxonomic allocation. On the basis of 16S rRNA gene sequences, strain KSS164-79T shared highest similarity (92.3-92.4 %) to type strains of the species Marinicrinis sediminis,Paenibacillus dongdonensis, Paenibacillus abyssi and Paenibacillus motobuensis. In phylogenetic trees based on the 16S rRNA gene, strain KSS164-79T always formed a distinct cluster with the type strain of M. sediminis. The fatty acid profile supported the grouping of the strain to the genus Marinicrinis...
February 9, 2018: International Journal of Systematic and Evolutionary Microbiology
Johannes Schellenberg, Hans-Jürgen Busse, Martin Hardt, Patrick Schubert, Thomas Wilke, Peter Kämpfer, Stefanie P Glaeser
A bright-orange-pigmented, Gram-stain-negative, motile, and rod-shaped bacterium, strain MAA42T , was isolated from a marine sponge of the genus Haliclona, which is in long-time culture in a marine aquarium system at the Justus Liebig University Giessen, Germany. The strain grew at 4-34 °C (optimum 28 °C), in the presence of 0.5-9.5 % (w/v) NaCl (optimum 3.5 %) and at pH 4.5-10.0 (optimum pH 7.5). Strain MAA42T shared the highest 16S rRNA gene sequence similarity (98.1 %) with the type strain of Litorimonas taeanensis...
February 1, 2018: International Journal of Systematic and Evolutionary Microbiology
A Silambarasu, A Manikandan, K Balakrishnan, Saravana Kumar Jaganathan, E Manikandan, Jagathrakshakan Sundeep Aanand
Spinel MnFe2O4 nanostructures were synthesized by simple, economical and eco-friendly microwave combustion (MCM) and conventional combustion (CCM) methods using metal nitrates and glycine used as the fuel, instead of toxic inorganic/organic catalyst, template and surfactant. Powder XRD and FT-IR, EDX and SAED results were confirmed the products have a cubic phase spinel structure. EDX and SAED results confirmed purity and high crystallinity without any other secondary phase impurities. HR-SEM and HR-TEM analysis indicate that the MCM and CCM products consist of nano- and microstructures, respectively...
May 1, 2018: Journal of Nanoscience and Nanotechnology
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