keyword
MENU ▼
Read by QxMD icon Read
search

CCM

keyword
https://www.readbyqxmd.com/read/29330879/biotechnological-conversion-of-spent-coffee-grounds-into-lactic-acid
#1
Helena Hudeckova, Markus Neureiter, Stanislav Obruca, Sabine Frühauf, Ivana Marova
This work investigates the potential conversion of spent coffee grounds (SCG) into lactic acid (LA). SCG were hydrolysed by a combination of dilute acid treatment and subsequent application of cellulase. The SCG hydrolysate contained a considerable amount of reducing sugars (9.02 ± 0.03 g l-1 , glucose; 26.49 ± 0.10 g l-1 galactose and 2.81 ± 0.07 g l-1 arabinose) and it was used as a substrate for cultivation of several lactic acid bacteria (LAB) and also lactic acid producing Bacillus coagulans. Among the screened microorganisms, Lactobacillus rhamnosus, CCM 1825 was identified as the most promising producer of LA on SCG hydrolysate...
January 13, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29325940/clinical-features-treatment-and-prognostic-factors-of-56-intracranial-and-intraspinal-clear-cell-meningiomas
#2
Xiaogang Tao, Jinqian Dong, Zonggang Hou, Shuyu Hao, Junting Zhang, Zhen Wu, Baiyun Liu
OBJECTIVE: Intracranial and intraspinal clear cell meningiomas (CCMs) are rarely reported because of their extremely low incidence, and the current understanding of CCM is poor. The purpose of this study was to analyze the incidence and the clinical, radiological, pathological, and prognostic features of intracranial and intraspinal CCMs. METHODS: Among 14310 cases of intracranial and intraspinal meningiomas that were surgically treated between 2006 and 2016 at Beijing Tian Tan Hospital, 56 were chosen for analysis and retrospectively reviewed...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29320853/high-co2-requirement-as-a-mechanism-for-the-containment-of-genetically-modified-cyanobacteria
#3
Ryan L Clark, Gina C Gordon, Nathaniel R Bennett, Haoxiang Lyu, Thatcher W Root, Brian F Pfleger
As researchers engineer cyanobacteria for biotechnological applications, we must consider potential environmental release of these organisms. Previous theoretical work has considered cyanobacterial containment through elimination of the CO2-concentrating mechanism (CCM) to impose a high-CO2 requirement (HCR), which could be provided in the cultivation environment but not in the surroundings. In this work, we experimentally implemented an HCR containment mechanism in Synechococcus sp. PCC7002 (PCC7002) through deletion of carboxysome shell proteins and showed that this mechanism contained cyanobacteria in a 5% CO2 environment...
January 10, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29294682/is-readiness-to-take-action-among-women-in-violent-relationships-a-catastrophic-phenomenon
#4
David A Katerndahl, Sandra K Burge, Robert L Ferrer, Johanna Becho, Robert Wood
Taking action among women in violent relationships appears to involve sudden changes and reversals after periods of building stress, suggesting that decision making is a "catastrophic" phenomenon. This study sought to determine whether readiness-to-change is best modeled as a cusp catastrophic (CCM) phenomenon among women in violent relationships. A total of 143 women who experienced violence in the previous month completed baseline and end-of-study interviews assessing her hope, coping strategies, social network, and readiness-for-action (seeking help, taking legal action, and leaving) concerning the violence...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29282261/abc-index-quantifying-experienced-burden-of-copd-in-a-discrete-choice-experiment-and-predicting-costs
#5
Lucas Ma Goossens, Maureen Pmh Rutten-van Mölken, Melinde Rs Boland, Bas Donkers, Marcel F Jonker, Annerika Hm Slok, Philippe L Salomé, Onno Cp van Schayck, Johannes Ccm In 't Veen, Elly A Stolk
OBJECTIVE: The Assessment of Burden of COPD (ABC) tool supports shared decision making between patient and caregiver. It includes a coloured balloon diagram to visualise patients' scores on burden indicators. We aim to determine the importance of each indicator from a patient perspective, in order to calculate a weighted index score and investigate whether that score is predictive of costs. DESIGN: Discrete choice experiment. SETTING AND PARTICIPANTS: Primary care and secondary care in the Netherlands...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29276386/guided-bone-regeneration-with-asymmetric-collagen-chitosan-membranes-containing-aspirin-loaded-chitosan-nanoparticles
#6
Jiayu Zhang, Shiqing Ma, Zihao Liu, Hongjuan Geng, Xin Lu, Xi Zhang, Hongjie Li, Chenyuan Gao, Xu Zhang, Ping Gao
Introduction: Membranes allowing the sustained release of drugs that can achieve cell adhesion are very promising for guided bone regeneration. Previous studies have suggested that aspirin has the potential to promote bone regeneration. The purpose of this study was to prepare a local drug delivery system with aspirin-loaded chitosan nanoparticles (ACS) contained in an asymmetric collagen-chitosan membrane (CCM). Methods: In this study, the ACS were fabricated using different concentrations of aspirin (5 mg, 25 mg, 50 mg, and 75 mg)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29239716/pseudomonas-fluvialis-sp-nov-a-novel-member-of-the-genus-pseudomonas-isolated-from-the-river-ganges-india
#7
Sarabjeet Kour Sudan, Deepika Pal, Bhawana Bisht, Narender Kumar, Vasvi Chaudhry, Prabhu Patil, Girish Sahni, Shanmugam Mayilraj, Srinivasan Krishnamurthi
A bacterial strain, designated ASS-1T, was isolated and identified from a sediment sample of the river Ganges, Allahabad, India. The strain was Gram-stain-negative, formed straw-yellow pigmented colonies, was strictly aerobic, motile with a single polar flagellum, and positive for oxidase and catalase. The major fatty acids were C16 : 1ω7c/ 16 : 1 C16 : 1ω6c, C18 : 1ω7c and C16 : 0. Sequence analysis based on the 16S rRNA gene revealed that strain ASS-1T showed high similarity to Pseudomonas guguanensis CC-G9AT (98...
December 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29236970/seen-through-the-patients-eyes-quality-of-chronic-illness-care
#8
Melissa Desmedt, Sonja Vertriest, Mirko Petrovic, Jochen Bergs, Hubertus Vrijhoef, Ezra Dessers, Johan Hellings, Dominique Vandijck
Background: Most well-developed healthcare systems are facing the challenge of managing the increasing prevalence of patients with chronic diseases. Comprehensive frameworks, such as the chronic care model (CCM), receive widespread acceptance for improving care processes, clinical outcomes and costs. Objective: The purpose of this study was to explore chronic patients' perceptions of the quality of chronic care and the alignment with the CCM. Since previous research indicated that a patient's assessment may depend on socio-demographic or disease-related characteristics, the relationship between the mean Patient Assessment of Chronic Illness Care (PACIC) score and possible aforementioned predictors was also explored...
December 10, 2017: Family Practice
https://www.readbyqxmd.com/read/29225318/caffeine-stimulated-intestinal-epithelial-cells-suppress-lipid-accumulation-in-adipocytes
#9
Takakazu Mitani, Tomoya Nagano, Kiyonari Harada, Yoko Yamashita, Hitoshi Ashida
Caffeine is a methylxanthine derived from plant foods such as coffee beans and tea leaves, and has multiple biological activities against physiological response and several diseases. Although there are some reports about the direct effect of caffeine against anti-lipid accumulation in vitro, the effect of caffeine on lipid accumulation in adipocytes through stimulating intestinal epithelial cells is unknown. Since direct treatment with caffeine to 3T3-L1 cells did not affect lipid accumulation, we determined whether caffeine-stimulated intestinal epithelial Caco-2 cells influence the lipid accumulation in 3T3-L1 adipocytes...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29221815/corneal-confocal-microscopy-as-a-non-invasive-test-to-assess-diabetic-peripheral-neuropathy
#10
Qian Xiong, Bin Lu, Hong-Ying Ye, Si-Ying Liu, Hang-Ping Zheng, Rui-Yun Zhang, Xiao-Na Qiao, Shuo Zhang, Xiao-Xia Liu, Qing-Chun Li, Na Yi, Liang-Cheng Wu, Jie Wen, Tian-Song Zhang, Yi-Ming Li
OBJECTIVE: To evaluate the efficacy of corneal confocal microscopy (CCM)as a non-invasive test to assess diabetic peripheral neuropathy in Chinese patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Diabetic distal symmetric polyneuropathy (DSPN) and its severity degrees were assessed based on the modified Toronto diagnostic criteria in 128 patients with type 2 diabetes (No DSPN [n = 49], mild DSPN [n = 43], moderate-to-severe DSPN [n = 36]) and 24 age-matched controls...
December 5, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29203912/bacterial-resistance-to-silver-nanoparticles-and-how-to-overcome-it
#11
Aleš Panáček, Libor Kvítek, Monika Smékalová, Renata Večeřová, Milan Kolář, Magdalena Röderová, Filip Dyčka, Marek Šebela, Robert Prucek, Ondřej Tomanec, Radek Zbořil
Silver nanoparticles have already been successfully applied in various biomedical and antimicrobial technologies and products used in everyday life. Although bacterial resistance to antibiotics has been extensively discussed in the literature, the possible development of resistance to silver nanoparticles has not been fully explored. We report that the Gram-negative bacteria Escherichia coli 013, Pseudomonas aeruginosa CCM 3955 and E. coli CCM 3954 can develop resistance to silver nanoparticles after repeated exposure...
January 2018: Nature Nanotechnology
https://www.readbyqxmd.com/read/29197946/first-large-genomic-inversion-in-familial-cerebral-cavernous-malformation-identified-by-whole-genome-sequencing
#12
Stefanie Spiegler, Matthias Rath, Sabine Hoffjan, Philipp Dammann, Ulrich Sure, Axel Pagenstecher, Tim Strom, Ute Felbor
Familial cerebral cavernous malformations (CCMs) predispose to seizures and hemorrhagic stroke. Molecular genetic analyses of CCM1, CCM2, and CCM3 result in a mutation detection rate of up to 98%. However, only whole genome sequencing (WGS) in combination with the Manta algorithm for analyses of structural variants revealed a heterozygous 24 kB inversion including exon 1 of CCM2 in a 12-year-old boy with familial CCMs. Its breakpoints were fine-mapped, and quantitative analysis on RNA confirmed reduced CCM2 expression...
December 2, 2017: Neurogenetics
https://www.readbyqxmd.com/read/29189958/surgical-treatment-of-spinal-metastases-from-renal-cell-carcinoma-effects-of-preoperative-embolization-on-intraoperative-blood-loss
#13
Matthias Reitz, Klaus Christian Mende, Christopher Cramer, Theresa Krätzig, ZSuzsanna Nagy, Eik Vettorazzi, Sven Oliver Eicker, Marc Dreimann
The objective of this paper is analyzing the effects of preoperative embolization on intraoperative blood loss in spinal surgery for renal cell carcinoma (RCC) metastasis and identifying factors contributing to an increased blood loss in the surgical procedure. A retrospective analysis was performed in patients who were treated in for spinal metastasis from RCC between 2011 and 2016. Factors analyzed were reduction of tumor blush, timing of embolization, selective vs. superselective approach, surgical factors, and tumor volume and localization...
November 30, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29188095/comparison-of-four-methods-of-surface-roughness-assessment-of-corneal-stromal-bed-after-lamellar-cutting
#14
Clotilde Jumelle, Alina Hamri, Gregory Egaud, Cyril Mauclair, Stephanie Reynaud, Virginie Dumas, Sandrine Pereira, Thibaud Garcin, Philippe Gain, Gilles Thuret
Corneal lamellar cutting with a blade or femtosecond laser (FSL) is commonly used during refractive surgery and corneal grafts. Surface roughness of the cutting plane influences postoperative visual acuity but is difficult to assess reliably. For the first time, we compared chromatic confocal microscopy (CCM) with scanning electron microscopy, atomic force microscopy (AFM) and focus-variation microscopy (FVM) to characterize surfaces of variable roughness after FSL cutting. The small area allowed by AFM hinders conclusive roughness analysis, especially with irregular cuts...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29187184/rheumatic-heart-disease-infectious-disease-origin-chronic-care-approach
#15
REVIEW
Judith M Katzenellenbogen, Anna P Ralph, Rosemary Wyber, Jonathan R Carapetis
BACKGROUND: Rheumatic heart disease (RHD) is a chronic cardiac condition with an infectious aetiology, causing high disease burden in low-income settings. Affected individuals are young and associated morbidity is high. However, RHD is relatively neglected due to the populations involved and its lower incidence relative to other heart diseases. METHODS AND RESULTS: In this narrative review, we describe how RHD care can be informed by and integrated with models of care developed for priority non-communicable diseases (coronary heart disease), and high-burden communicable diseases (tuberculosis)...
November 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29176339/patient-and-nurse-experiences-in-a-rural-chronic-disease-management-program-a-qualitative-evaluation
#16
Erica A Davisson, Elizabeth A Swanson
PURPOSE: Rural status confounds chronic disease self-management. The purpose of this qualitative, descriptive study was to evaluate the nurse-led "Living Well" chronic disease management program reporting patient recruitment and retention issues since program initiation in 2013. The Chronic Care Model (CCM) was the guiding framework used to reinforce that interdisciplinary teams must have productive patient interactions for their program(s) to be sustainable. PRIMARY PRACTICE SETTING: A rural, Midwest county clinic's chronic disease management program...
January 2018: Professional Case Management
https://www.readbyqxmd.com/read/29175574/surgical-management-and-long-term-seizure-outcome-after-surgery-for-temporal-lobe-epilepsy-associated-with-cerebral-cavernous-malformations
#17
Peng-Fan Yang, Jia-Sheng Pei, Yan-Zeng Jia, Qiao Lin, Hui Xiao, Ting-Ting Zhang, Zhong-Hui Zhong
OBJECTIVE: Operative strategies for cerebral cavernous malformation (CCM)-associated temporal lobe epilepsy and timing of surgical intervention have continued under debate. This study aimed to establish an algorithm to evaluate efficacy of surgical intervention strategies, which maximizes positive surgical outcomes and minimizes post-surgical neurological deficits. METHODS: 47 subjects having undergone operation for CCM-associated temporal lobe epilepsy were retrospectively reviewed...
November 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29174462/critical-care-and-personalized-or-precision-medicine-who-needs-whom
#18
Shihab Sugeir, Stephen Naylor
The current paradigm of modern healthcare is a reactive response to patient symptoms, subsequent diagnosis and corresponding treatment of the specific disease(s). This approach is predicated on methodologies first espoused by the Cnidean School of Medicine approximately 2500years ago. More recently escalating healthcare costs and relatively poor disease treatment outcomes have fermented a rethink in how we carry out medical practices. This has led to the emergence of "P-Medicine" in the form of Personalized and Precision Medicine...
November 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29170092/krit1-loss-of-function-induces-a-chronic-nrf2-mediated-adaptive-homeostasis-that-sensitizes-cells-to-oxidative-stress-implication-for-cerebral-cavernous-malformation-disease
#19
Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Martina Daga, Stefania Pizzimenti, Giuseppina Barrera, Paola Cassoni, Adriano Angelucci, Lorenza Trabalzini, Vincenzo Nicola Talesa, Luca Goitre, Saverio Francesco Retta
KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3-0.5% of the population. Previously, we demonstrated that KRIT1 loss-of-function is associated with altered redox homeostasis and abnormal activation of the redox-sensitive transcription factor c-Jun, which collectively result in pro-oxidative, pro-inflammatory and pro-angiogenic effects, suggesting a novel pathogenic mechanism for CCM disease and raising the possibility that KRIT1 loss-of-function exerts pleiotropic effects on multiple redox-sensitive mechanisms...
November 20, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29169046/a-novel-ccm1-krit1-heterozygous-deletion-mutation-c-1919delt-in-a-chinese-family-with-familial-cerebral-cavernous-malformation
#20
Chenlong Yang, Bingquan Wu, Haohao Zhong, Yan Li, Xingzheng Zheng, Yulun Xu
BACKGROUND: Cerebral cavernous malformation (CCM) is a relatively rare congenital vascular anomaly in the central venous system. Its inherited form, familial cerebral cavernous malformation (FCCM), is an autosomal-dominant disease with incomplete penetrance. The pathogenic genes of FCCM have been mapped into three loci: CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10. Till now, the genetic basis of FCCM in the Chinese population has yet to be well understood. Herein, we investigated the genetic mutation in a Chinese family with FCCM...
November 20, 2017: Clinical Neurology and Neurosurgery
keyword
keyword
16898
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"