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https://www.readbyqxmd.com/read/28328846/prevalence-of-complications-after-surgery-in-treatment-for-cervical-compressive-myelopathy-a-meta-analysis-for-last-decade
#1
Tao Wang, Xiao-Ming Tian, Si-Kai Liu, Hui Wang, Ying-Ze Zhang, Wen-Yuan Ding
PURPOSE: We aim to perform a meta-analysis on prevalence of all kinds of operation-related complications following surgery treating cervical compressive myelopathy (CCM) and to provide reference for surgeons making surgical plan. METHODS: An extensive search of literature was performed in PubMed/MEDLINE, Embase, the Cochrane library, CNKI, and WANFANG databases on incidence of operation-related complications from January 2007 to November 2016. Data was calculated and data analysis was conducted with STATA 12...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327920/of-bubbles-and-layers-which-cerebral-cavernous-malformations-are-most-difficult-to-dissect-from-surrounding-eloquent-brain-tissue
#2
Philipp Dammann, Karsten Wrede, Ramazan Jabbarli, Oliver Müller, Christoph Mönninghoff, Michael Forsting, Ulrich Sure
BACKGROUND: Cerebral cavernous malformations (CCM) may lead to repetitive intracerebral hemorrhage. In selected cases, a surgical resection is indicated. OBJECTIVE: To identify magnetic resonance imaging (MRI) features of CCM that correlate with the difficulty of dissection and postoperative outcome. METHODS: This study prospectively analyzed pre- and postoperative MRI features, intraoperative findings (surgical questionnaire), and postoperative outcome of 41 patients with eloquent CCM...
March 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28322971/effects-and-mechanisms-of-compound-chinese-medicine-and-major-ingredients-on-microcirculatory-dysfunction-and-organ-injury-induced-by-ischemia-reperfusion
#3
REVIEW
Jing-Yan Han, Quan Li, Zhi-Zhong Ma, Jing-Yu Fan
Microcirculation dysfunction and organ injury after ischemia and reperfusion (I/R) result from a complex pathologic process consisting of multiple links, with metabolism impairment in the ischemia phase and oxidative stress in the reperfusion phase as initiators, and any treatment targeting a single link is insufficient to cope with this. Compound Chinese medicine (CCM) has been applied in clinics in China and some Asian nations for more than 2000 years. Studies over the past decades revealed the protective and therapeutic effect of CCMs and major ingredients on I/R-induced microcirculatory dysfunction and tissue injury in the heart, brain, liver, intestine, and so on...
March 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28318403/familial-cerebral-cavernous-malformations-are-associated-with-adrenal-calcifications-on-ct-scans-an-imaging-biomarker-for-a-hereditary-cerebrovascular-condition
#4
Corinne D Strickland, Steven C Eberhardt, Mary R Bartlett, Jeffrey Nelson, Helen Kim, Leslie A Morrison, Blaine L Hart
Purpose To determine if adrenal calcifications seen at computed tomography (CT) are associated with familial cerebral cavernous malformations (fCCMs) in carriers of the CCM1 Common Hispanic Mutation. Materials and Methods This study was approved by the institutional review board. The authors retrospectively reviewed abdominal CT scans in 38 patients with fCCM, 38 unaffected age- and sex-matched control subjects, and 13 patients with sporadic, nonfamilial cerebral cavernous malformation (CCM). The size, number, and laterality of calcifications and the morphologic characteristics of the adrenal gland were recorded...
March 20, 2017: Radiology
https://www.readbyqxmd.com/read/28300153/brucella-spp-of-amphibians-comprise-genomically-diverse-motile-strains-competent-for-replication-in-macrophages-and-survival-in-mammalian-hosts
#5
Sascha Al Dahouk, Stephan Köhler, Alessandra Occhialini, María Pilar Jiménez de Bagüés, Jens Andre Hammerl, Tobias Eisenberg, Gilles Vergnaud, Axel Cloeckaert, Michel S Zygmunt, Adrian M Whatmore, Falk Melzer, Kevin P Drees, Jeffrey T Foster, Alice R Wattam, Holger C Scholz
Twenty-one small Gram-negative motile coccobacilli were isolated from 15 systemically diseased African bullfrogs (Pyxicephalus edulis), and were initially identified as Ochrobactrum anthropi by standard microbiological identification systems. Phylogenetic reconstructions using combined molecular analyses and comparative whole genome analysis of the most diverse of the bullfrog strains verified affiliation with the genus Brucella and placed the isolates in a cluster containing B. inopinata and the other non-classical Brucella species but also revealed significant genetic differences within the group...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298332/impact-of-lifelong-exercise-training-on-endothelial-ischemia-reperfusion-and-ischemic-preconditioning-in-humans
#6
Martijn F H Maessen, Anke Ccm van Mil, Yaïra Straathof, Niels P Riksen, Gerard A P J M Rongen, Maria T E Hopman, Thijs M H Eijsvogels, Dick H J Thijssen
Reperfusion is essential for ischemic tissue survival, but causes additional damage to the endothelium (i.e. ischemia-reperfusion [IR] injury). Ischemic preconditioning (IPC) refers to short repetitive episodes of ischemia that can protect against IR. However, IPC efficacy attenuates with older age. Whether physical inactivity contributes to the attenuated efficacy of IPC to protect against IR injury in older humans is unclear. We tested the hypotheses that lifelong exercise training relates to 1) attenuated endothelial IR and 2) maintained IPC efficacy that protects veteran athletes against endothelial IR...
March 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28296936/spatial-analysis-improves-the-detection-of-early-corneal-nerve-fiber-loss-in-patients-with-recently-diagnosed-type-2-diabetes
#7
Dan Ziegler, Karsten Winter, Alexander Strom, Andrey Zhivov, Stephan Allgeier, Nikolaos Papanas, Iris Ziegler, Jutta Brüggemann, Bernd Ringel, Sabine Peschel, Bernd Köhler, Oliver Stachs, Rudolf F Guthoff, Michael Roden
Corneal confocal microscopy (CCM) has revealed reduced corneal nerve fiber (CNF) length and density (CNFL, CNFD) in patients with diabetes, but the spatial pattern of CNF loss has not been studied. We aimed to determine whether spatial analysis of the distribution of corneal nerve branching points (CNBPs) may contribute to improving the detection of early CNF loss. We hypothesized that early CNF decline follows a clustered rather than random distribution pattern of CNBPs. CCM, nerve conduction studies (NCS), and quantitative sensory testing (QST) were performed in a cross-sectional study including 86 patients recently diagnosed with type 2 diabetes and 47 control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28285997/ccm-3-promotes-c-%C3%A2-elegans-germline-development-by-regulating-vesicle-trafficking-cytokinesis-and-polarity
#8
Swati Pal, Benjamin Lant, Bin Yu, Ruilin Tian, Jiefei Tong, Jonathan R Krieger, Michael F Moran, Anne-Claude Gingras, W Brent Derry
Cerebral cavernous malformations (CCMs) are vascular defects of the CNS that arise from loss of integrity of the endothelial cells lining blood capillaries, causing leakage of blood into the brain [1]. This results in headaches, seizures, and/or hemorrhagic stroke, depending on the location of the lesion. CCM affects 0.5% of the population and follows an autosomal dominant inheritance pattern caused by mutations in one of the three genes: CCM1 (gene name KRIT1), CCM2 (also known as malcavernin or OSM), and CCM3 (gene name PDCD10) [2, 3], with the earliest onset and most severe prognosis occurring in CCM3 patients [4]...
March 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28285996/a-sterile-20-family-kinase-and-its-co-factor-ccm-3-regulate-contractile-ring-proteins-on-germline-intercellular-bridges
#9
Kathryn Rehain-Bell, Andrew Love, Michael E Werner, Ian MacLeod, John R Yates, Amy Shaub Maddox
Germ cells in most animals are connected by intercellular bridges, actin-based rings that form stable cytoplasmic connections between cells promoting communication and coordination [1]. Moreover, these connections are required for fertility [1, 2]. Intercellular bridges are proposed to arise from stabilization of the cytokinetic ring during incomplete cytokinesis [1]. Paradoxically, proteins that promote closure of cytokinetic rings are enriched on stably open intercellular bridges [1, 3, 4]. Given this inconsistency, the mechanism of intercellular bridge stabilization is unclear...
March 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28283769/-in-vivo-imaging-of-the-corneal-nerve-plexus-from-single-image-to-large-scale-map
#10
B Köhler, S Allgeier, A Bartschat, R F Guthoff, S Bohn, K-M Reichert, O Stachs, K Winter, R Mikut
The sub-basal nerve plexus (SNP) of the cornea provides the possibility of in vivo and non-invasive examination of peripheral nerve structures by corneal confocal microscopy (CCM). Thus morphological alterations of the SNP can be directly detected and quantified. A single CCM image is insufficient for a well-founded diagnosis because of the inhomogeneous distribution of the nerve fibers; therefore, there is a demand for techniques for large area imaging of the SNP. This article provides an overview of published approaches to the problem...
March 10, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28283353/hornworts-an-overlooked-window-into-carbon-concentrating-mechanisms
#11
Fay-Wei Li, Juan Carlos Villarreal, Péter Szövényi
Hornworts are the only land plant lineage harboring a biophysical carbon-concentrating mechanism (CCM). Here, we argue that hornworts are a promising, yet currently overlooked, model system to study the evolution and genetic basis of CCMs. The results of such studies could have translational values toward engineering a CCM in crop plants.
March 7, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28282135/silver-nanoparticles-and-metallic-silver-interfere-with-the-griess-reaction-reduction-of-the-azo-dye-formation-via-a-competing-sandmeyer-like-reaction
#12
Angela Kaempfer, Rita La Spina, Douglas Gilliland, Sandro Valzacchi, David Asturiol, Vicki Stone, Agnieszka Kinsner-Ovaskainen
Silver (Ag) is the most common nanomaterial (NM) in consumer products. Much research has been focused on elucidating the potential impact of Ag-containing NMs on human health, e.g. cytotoxicity, genotoxicity or pro-inflammatory responses. In the case of pro-inflammatory response a frequently used endpoint is the induction of nitric oxide (NO), which is indirectly quantified as nitrite (NO2-) with the Griess reaction. After preliminary studies in a macrophage-like cell culture system showed anomalous false negative results in presence of silver nanoparticles (Ag NPs), we studied the influence of Ag on the detection of NO2- in a cell-free environment...
March 10, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28281229/potential-of-pichia-pastoris-for-the-production-of-industrial-penicillin-g-acylase
#13
Helena Marešová, Andrea Palyzová, Martina Plačková, Michal Grulich, Vyasa Williams Rajasekar, Václav Štěpánek, Eva Kyslíková, Pavel Kyslík
This study deals with the potential of Pichia pastoris X-33 for the production of penicillin G acylase (PGA(A)) from Achromobacter sp. CCM 4824. Synthetic gene matching the codon usage of P. pastoris was designed for intracellular and secretion-based production strategies and cloned into vectors pPICZ and pPICZα under the control of AOX1 promoter. The simple method was developed to screen Pichia transformants with the intracellularly produced enzyme. The positive correlation between acylase production and pga gene dosage for both expression systems was demonstrated in small scale experiments...
March 9, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28273517/enhancing-soybean-photosynthetic-co2-assimilation-using-a-cyanobacterial-membrane-protein-ictb
#14
William T Hay, Saadia Bihmidine, Nedim Mutlu, Khang Le Hoang, Tala Awada, Donald P Weeks, Tom E Clemente, Stephen P Long
Soybean C3 photosynthesis can suffer a severe loss in efficiency due to photorespiration and the lack of a carbon concentrating mechanism (CCM) such as those present in other plant species or cyanobacteria. Transgenic soybean (Glycine max cv. Thorne) plants constitutively expressing cyanobacterial ictB (inorganic carbon transporter B) gene were generated using Agrobacterium-mediated transformation. Although more recent data suggest that ictB does not actively transport HCO3-/CO2, there is nevertheless mounting evidence that transformation with this gene can increase higher plant photosynthesis...
February 16, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28270122/implementation-of-integrated-geriatric-care-at-a-german-hospital-a-case-study-to-understand-when-and-why-beneficial-outcomes-can-be-achieved
#15
Loraine Busetto, Jörn Kiselev, Katrien Ger Luijkx, Elisabeth Steinhagen-Thiessen, Hubertus Johannes Maria Vrijhoef
BACKGROUND: Many health systems have implemented integrated care as an alternative approach to health care delivery that is more appropriate for patients with complex, long-term needs. The objective of this article was to analyse the implementation of integrated care at a German geriatric hospital and explore whether the use of a "context-mechanisms-outcomes"-based model provides insights into when and why beneficial outcomes can be achieved. METHODS: We conducted 15 semi-structured interviews with health professionals employed at the hospital...
March 7, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28268790/analysis-of-causal-cardio-postural-interaction-under-orthostatic-stress-using-convergent-cross-mapping
#16
Ajay K Verma, Amanmeet Garg, Andrew Blaber, Reza Fazel-Rezai, Kouhyar Tavakolian
Knowledge of a cause-and-effect relationship between different physiological systems is helpful in predicting their performance under perturbations, such as orthostatic challenge. The causal coupling between representative signals of the cardiovascular and postural systems under orthostatic challenge remains unknown. Understanding the causal relationship between these two systems is critical, as their interplay is vital to maintain stable upright posture of the human body during quiet standing. In this research, convergent cross mapping (CCM) method was applied to study the causal relationship between the cardiovascular and postural systems previously shown to have coherent activity during quiet standing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266042/rare-case-of-vascular-malformations-in-both-skin-and-brain-case-report-and-published-work-review
#17
Masahiro Oka, Masanobu Sakaguchi, Takeshi Fukumoto, Shin-Ichiro Seki, Chikako Nishigori
Solitary venous malformation (VM) of the skin, previously known as cavernous hemangioma, is frequently observed in the dermatological field, but multiple acquired VM are rare. We present a case of multiple VM of the skin associated with multiple cerebral cavernous malformations (CCM) in a 70-year-old Japanese woman. In addition, we summarize seven reported similar cases, including the present case. That some reports have described concomitant VM of the skin and CCM, together with the present case, suggests a tight relationship or a common pathogenetic pathway between these two diseases...
March 7, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28258973/rapid-automated-mosaicking-of-the-human-corneal-subbasal-nerve-plexus
#18
Yash J Vaishnav, Stuart A Rucker, Keshav Saharia, Nancy A McNamara
Corneal confocal microscopy (CCM) is an in vivo technique used to study corneal nerve morphology. The largest proportion of nerves innervating the cornea lie within the subbasal nerve plexus, where their morphology is altered by refractive surgery, diabetes and dry eye. The main limitations to clinical use of CCM as a diagnostic tool are the small field of view of CCM images and the lengthy time needed to quantify nerves in collected images. Here, we present a novel, rapid, fully automated technique to mosaic individual CCM images into wide-field maps of corneal nerves...
March 4, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28255959/a-novel-ccm1-krit1-heterozygous-nonsense-mutation-c-1864c-t-associated-with-familial-cerebral-cavernous-malformation-a-genetic-insight-from-an-8-year-continuous-observational-study
#19
Chenlong Yang, Van Halm-Lutterodt Nicholas, Jizong Zhao, Bingquan Wu, Haohao Zhong, Yan Li, Yulun Xu
Cerebral cavernous malformation (CCM) is a congenital vascular abnormality that predominantly affects the central nervous system, but that sometimes encroaches other vital tissues, including the retina, skin, and even liver. The familial form of CCM (FCCM) is considered to be an autosomal dominant disease with incomplete penetrance and variable expression, which is often attributed to mutations in three genes: CCM1, CCM2, and CCM3. We screened a Chinese family diagnosed with FCCM by using Sanger sequencing...
March 2, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28245937/does-energetic-cost-for-leaf-construction-in-sonneratia-change-after-introduce-to-another-mangrove-wetland-and-differ-from-native-mangrove-plants-in-south-china
#20
Feng-Lan Li, Lei Yang, Qi-Jie Zan, Paul-K S Shin, Siu-Gin Cheung, Yuk-Shan Wong, Nora Fung-Yee Tam, An-Ping Lei
Exotic species invasions are serious ecological problems. Leaf construction cost (CC) and growth traits of two Sonneratia (Sonneratia caseolaris and S. apetala) and four native species (Bruguiera gymnorrhiza, Kandelia obovata, Aegiceras corniculatum and Avicennia marina) in Hainan and Shenzhen mangrove wetlands were compared to evaluate invasive potentials of Sonneratia after introduced to Shenzhen, their new habitat. There were no significant differences in CC and growth traits between two wetlands, suggesting Sonneratia did not lose any advantage in the new habitat and were competitive in both wetlands...
February 25, 2017: Marine Pollution Bulletin
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