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https://www.readbyqxmd.com/read/27902980/gene-expression-profiling-and-functional-characterization-of-macrophages-in-response-to-circulatory-microparticles-produced-during-trypanosoma-cruzi-infection-and-chagas-disease
#1
Imran H Chowdhury, Sue-Jie Koo, Shivali Gupta, Lisa Yi Liang, Bojlul Bahar, Laura Silla, Julio Nuñez-Burgos, Natalia Barrientos, Maria Paola Zago, Nisha Jain Garg
BACKGROUND: Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of clinical disease. METHODS: MPs were harvested from supernatants of human peripheral blood mononuclear cells in vitro incubated with Tc (control: LPS treated), plasma of seropositive humans with a clinically asymptomatic (CA) or symptomatic (CS) disease state (vs...
December 1, 2016: Journal of Innate Immunity
https://www.readbyqxmd.com/read/27902352/cohnella-lubricantis-sp-nov-isolated-from-a-coolant-lubricant-solution
#2
Peter Kämpfer, Stefanie P Glaeser, Hans-Jürgen Busse
A Gram-staining-positive, aerobic, non-endospore forming organism, isolated from a coolant lubricant solution was studied for its taxonomic position. On the basis of 16S rRNA gene sequence similarity comparisons, strain KSS-154-50T was grouped into the genus Cohnella, most closely related to Cohnella formosensis ALFALFA-35T (97.3 %), Cohnella rhizosphaerae CSE-5610T (97.1 %) and Cohnella nanjingensis D-45T (97.0%). The 16S rRNA gene sequence similarity to other Cohnella species was < 97.0 %. The fatty acid profile from whole cell hydrolysates was very similar to those reported for other Cohnella species supported the allocation to the genus Cohnella...
November 9, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902232/aeromicrobium-choanae-sp-nov-a-novel-actinobacterium-isolated-from-the-choana-of-a-garden-warbler
#3
Polona Ber, Stefanie Van Trappen, Peter Vandamme, Janja Trcek
A Gram-positive, non-spore forming actinobacterium strain 9H-4T isolated from the choana of a garden warbler (Sylvia borin) was studied to examine its taxonomic position. On the basis of the 16S rRNA gene sequence analysis it was shown that strain 9H-4T belongs to the genus Aeromicrobium with Aeromicrobium flavum (98.7 %) and Aeromicrobium tamlense (98.4 %) as the nearest neighbours and forms a separate branch in a neighbour-joining 16S rRNA gene sequence based phylogenetic tree. DNA-DNA hybridizations confirmed its novel species identity by 39 % and 46 % DNA-DNA relatedness with Aeromicrobium flavum DSM 19355T and Aeromicrobium tamlense DSM 19087T, respectively...
November 3, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27896269/cerebral-cavernous-malformations-review-of-the-genetic-and-protein-protein-interactions-resulting-in-disease-pathogenesis
#4
REVIEW
Jacob F Baranoski, M Yashar S Kalani, Colin J Przybylowski, Joseph M Zabramski
Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions composed of aberrantly enlarged "cavernous" endothelial channels that can result in cerebral hemorrhage, seizures, and neurologic deficits. Although these genes have been known to be associated with CCMs since the 1990s, numerous discoveries have been made that better elucidate how they and their subsequent protein products are involved in CCM pathogenesis...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27888169/impact-of-information-technology-based-interventions-for-type-2-diabetes-mellitus-on-glycemic-control-a-systematic-review-and-meta-analysis
#5
Nouf Sahal Alharbi, Nada Alsubki, Simon Jones, Kamlesh Khunti, Neil Munro, Simon de Lusignan
BACKGROUND: Information technology-based interventions are increasingly being used to manage health care. However, there is conflicting evidence regarding whether these interventions improve outcomes in people with type 2 diabetes. OBJECTIVE: The objective of this study was to conduct a systematic review and meta-analysis of clinical trials, assessing the impact of information technology on changes in the levels of hemoglobin A1c (HbA1c) and mapping the interventions with chronic care model (CCM) elements...
November 25, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27879448/rhoa-kinase-inhibition-with-fasudil-versus-simvastatin-in-murine-models-of-cerebral-cavernous-malformations
#6
Robert Shenkar, Changbin Shi, Cecilia Austin, Thomas Moore, Rhonda Lightle, Ying Cao, Lingjiao Zhang, Meijing Wu, Hussein A Zeineddine, Romuald Girard, David A McDonald, Autumn Rorrer, Carol Gallione, Peter Pytel, James K Liao, Douglas A Marchuk, Issam A Awad
BACKGROUND AND PURPOSE: We sought to compare the effect of chronic treatment with commonly tolerated doses of Fasudil, a specific RhoA kinase (ROCK) inhibitor, and simvastatin (with pleiotropic effects including ROCK inhibition) on cerebral cavernous malformation (CCM) genesis and maturation in 2 models that recapitulate the human disease. METHODS: Two heterozygous murine models, Ccm1(+/-)Msh2(-)(/-) and Ccm2(+/-)Trp53(-/-), were treated from weaning to 4 to 5 months of age with Fasudil (100 mg/kg per day), simvastatin (40 mg/kg per day) or with placebo...
November 22, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27872113/does-integrated-care-reduce-hospital-activity-for-patients-with-chronic-diseases-an-umbrella-review-of-systematic-reviews
#7
Sarah Damery, Sarah Flanagan, Gill Combes
OBJECTIVE: To summarise the evidence regarding the effectiveness of integrated care interventions in reducing hospital activity. DESIGN: Umbrella review of systematic reviews and meta-analyses. SETTING: Interventions must have delivered care crossing the boundary between at least two health and/or social care settings. PARTICIPANTS: Adult patients with one or more chronic diseases. DATA SOURCES: MEDLINE, Embase, ASSIA, PsycINFO, HMIC, CINAHL, Cochrane Library (HTA database, DARE, Cochrane Database of Systematic Reviews), EPPI-Centre, TRIP, HEED, manual screening of references...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27860023/evaluation-of-a-novel-computer-color-matching-system-based-on-the-improved-back-propagation-neural-network-model
#8
Jiaqiang Wei, Mengdong Peng, Qing Li, Yining Wang
PURPOSE: To explore the feasibility of a novel computer color-matching (CCM) system based on the improved back-propagation neural network (BPNN) model by comparing it with the traditional visual method. MATERIAL AND METHODS: Forty-three metal-ceramic specimens were fabricated by proportionally mixing porcelain powders. Thirty-nine specimens were randomly selected to train the BPNN model, while the remaining four specimens were used to test and calibrate the model...
November 9, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27858239/cervical-compressive-myelopathy-flow-analysis-of-cerebrospinal-fluid-using-phase-contrast-magnetic-resonance-imaging
#9
Yun Jung Bae, Joon Woo Lee, Eugene Lee, Jin S Yeom, Ki-Jeong Kim, Heung Sik Kang
PURPOSE: To evaluate cerebrospinal fluid (CSF) flow in cervical compressive myelopathy (CCM), by both quantitative and qualitative analyses, using 3T cine phase-contrast magnetic resonance imaging (cine MRI). METHODS: From September, 2014 to June, 2015, we enrolled 45 subjects (18 women and 27 men, mean age, 61.7 ± 13.4 years) to undergo cervical cine MRI. The subjects were divided into three groups: no stenosis and cervical stenosis with and without intramedullary T2 hyperintensity...
November 17, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27850019/379-pediatric-ccm-fellowship-bedside-ultrasound-curriculum-development
#10
Thomas Conlon, Adam Himebauch, Taiki Kojima, Christie Glau, Charlotte Woods-Hill, Donald Boyer, Robert Berg, Akira Nishisaki
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849745/101-the-model-matters-intensivist-model-has-large-mortality-cost-benefits-vs-consultative-ccm-icu-care
#11
James Love, Ahmad Maarouf, Chris Olis, Mona Obeidy
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27816564/community-health-workers-provide-integrated-community-case-management-using-malaria-rapid-diagnostic-test-kits
#12
Bright C Orji, Namratha Rao, Elizabeth Thompson, William R Brieger, Emmanuel 'Dipo Otolorin
BACKGROUND: Throughout Nigeria malaria is an endemic disease. Efforts to treat malaria can also be combined with other illnesses including pneumonia and diarrhea, which are killing children under five years of age. The use of Rapid Diagnostic Test (RDT) aids early diagnosis of malaria and informs when other illnesses should be considered. Those with positive RDT results should be treated with Artemisinin-based Combination Therapy (ACTs), while those with negative RDTs results are further investigated for pneumonia and diarrhea...
October 26, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27801810/novel-halogenated-pyrazine-based-chalcones-as-potential-antimicrobial-drugs
#13
Marta Kucerova-Chlupacova, Veronika Vyskovska-Tyllova, Lenka Richterova-Finkova, Jiri Kunes, Vladimir Buchta, Marcela Vejsova, Pavla Paterova, Lucia Semelkova, Ondrej Jandourek, Veronika Opletalova
Chalcones, i.e., compounds with the chemical pattern of 1,3-diphenylprop-2-en-1-ones, exert a wide range of bio-activities, e.g., antioxidant, anti-inflammatory, anticancer, anti-infective etc. Our research group has been focused on pyrazine analogues of chalcones; several series have been synthesized and tested in vitro on antifungal and antimycobacterial activity. The highest potency was exhibited by derivatives with electron withdrawing groups (EWG) in positions 2 and 4 of the ring B. As halogens also have electron withdrawing properties, novel halogenated derivatives were prepared by Claisen-Schmidt condensation...
October 27, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27797778/network-based-analysis-of-omics-data-the-lean-method
#14
Frederik Gwinner, Gwénola Boulday, Claire Vandiedonck, Minh Arnould, Cécile Cardoso, Iryna Nikolayeva, Oriol Guitart-Pla, Cécile V Denis, Olivier D Christophe, Johann Beghain, Elisabeth Tournier-Lasserve, Benno Schwikowski
MOTIVATION: Most computational approaches for the analysis of omics data in the context of interaction networks have very long running times, provide single or partial, often heuristic, solutions, and/or contain user-tuneable parameters. RESULTS: We introduce local enrichment analysis (LEAN) for the identification of dysregulated subnetworks from genome-wide omics data sets. By substituting the common subnetwork model with a simpler local subnetwork model, LEAN allows exact, parameter-free, efficient, and exhaustive identification of local subnetworks that are statistically dysregulated, and directly implicates single genes for follow-up experiments...
October 26, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27792117/use-of-central-motor-conduction-time-and-spinal-cord-evoked-potentials-in-the-electrophysiological-assessment-of-compressive-cervical-myelopathy
#15
Kazuhiro Fujimoto, Tsukasa Kanchiku, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Norihiro Nishida, Toshihiko Taguchi
STUDY DESIGN: Retrospective study. OBJECTIVE: This study investigated the pathophysiology of compressive cervical myelopathy (CCM) with prolonged central motor conduction time (CMCT) in the upper limbs (UL) rather than lower limbs (LL) and prolonged CMCT at the thoracic level (TL). SUMMARY OF BACKGROUND DATA: Earlier reports indicated the usefulness of CMCT to assess preoperative CCM severity. However little information exists on patients with prolonged CMCT-UL rather than CMCT-LL and prolonged CMCT-TL...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27791081/chloroplast-mediated-regulation-of-co2-concentrating-mechanism-by-ca2-binding-protein-cas-in-the-green-alga-chlamydomonas-reinhardtii
#16
Lianyong Wang, Takashi Yamano, Shunsuke Takane, Yuki Niikawa, Chihana Toyokawa, Shin-Ichiro Ozawa, Ryutaro Tokutsu, Yuichiro Takahashi, Jun Minagawa, Yu Kanesaki, Hirofumi Yoshikawa, Hideya Fukuzawa
Aquatic photosynthetic organisms, including the green alga Chlamydomonas reinhardtii, induce a CO2-concentrating mechanism (CCM) to maintain photosynthetic activity in CO2-limiting conditions by sensing environmental CO2 and light availability. Previously, a novel high-CO2-requiring mutant, H82, defective in the induction of the CCM, was isolated. A homolog of calcium (Ca(2+))-binding protein CAS, originally found in Arabidopsis thaliana, was disrupted in H82 cells. Although Arabidopsis CAS is reported to be associated with stomatal closure or immune responses via a chloroplast-mediated retrograde signal, the relationship between a Ca(2+) signal and the CCM associated with the function of CAS in an aquatic environment is still unclear...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27790124/cerebral-cavernous-malformation-a-portuguese-family-with-a-novel-ccm1-mutation
#17
João Pedro Marto, Inês Gil, Sofia Calado, Miguel Viana-Baptista
INTRODUCTION: Cerebral cavernous malformation (CCM) is a vascular disorder characterized by the presence of central nervous system cavernomas. In familial forms, mutations in three genes (CCM1/KRIT1, CCM2/MGC4607 and CCM3/PDCD10) were identified. We describe a Portuguese family harboring a novel CCM1 mutation. CASE PRESENTATION: The proband is a woman who at the age of 55 years started to have complex partial seizures and episodic headache. Although nothing was found during her neurological examination, brain MRI showed bilateral, supra- and infratentorial cavernomas...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27775614/curcumin-shows-antiviral-properties-against-norovirus
#18
Minji Yang, GilJae Lee, Jiyeon Si, Sung-Joon Lee, Hyun Ju You, GwangPyo Ko
Phytochemicals provide environmentally friendly and relatively inexpensive natural products, which could potentially benefit public health by controlling human norovirus (HuNoV) infection. In this study, 18 different phytochemicals were evaluated for antiviral effects against norovirus using murine norovirus (MNV) as a model for norovirus biology. Among these phytochemicals, curcumin (CCM) was the most potent anti-noroviral phytochemical, followed by resveratrol (RVT). In a cell culture infection model, exposure to CCM or RVT for 3 days reduced infectivity of norovirus by 91% and 80%, respectively...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27769232/research-in-disaster-settings-a-systematic-qualitative-review-of-ethical-guidelines
#19
Signe Mezinska, Péter Kakuk, Goran Mijaljica, Marcin Waligóra, Dónal P O'Mathúna
BACKGROUND: Conducting research during or in the aftermath of disasters poses many specific practical and ethical challenges. This is particularly the case with research involving human subjects. The extraordinary circumstances of research conducted in disaster settings require appropriate regulations to ensure the protection of human participants. The goal of this study is to systematically and qualitatively review the existing ethical guidelines for disaster research by using the constant comparative method (CCM)...
October 21, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27767360/a-novel-approach-to-analyze-the-progression-of-measured-corneal-sub-basal-nerve-fiber-length-in-continuously-expanding-mosaic-images
#20
Stephan Allgeier, Karsten Winter, Georg Bretthauer, Rudolf F Guthoff, Sabine Peschel, Klaus-Martin Reichert, Oliver Stachs, Bernd Köhler
: Purpose/Aim of the study: A recently proposed technique enables the generation of continuously increasing mosaic images of the corneal sub-basal nerve plexus (SNP) using in vivo corneal confocal microscopy (CCM). The aim of the present study was to investigate the progression of the corneal nerve fiber length (CNFL) measured in the growing mosaic images with regard to their increasing area. MATERIALS AND METHODS: Five large datasets from three healthy volunteers were examined using the proposed CCM technique...
October 21, 2016: Current Eye Research
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