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https://www.readbyqxmd.com/read/28216793/final-report-on-the-key-comparison-ccm-p-k4-2012-in-absolute-pressure-from-1-pa-to-10-kpa
#1
Jacob Ricker, Jay Hendricks, Thomas Bock, Pražák Dominik, Tokihiko Kobata, Jorge Torres, Irina Sadkovskaya
The report summarizes the Consultative Committee for Mass (CCM) key comparison CCM.P-K4.2012 for absolute pressure spanning the range of 1 Pa to 10 000 Pa. The comparison was carried out at six National Metrology Institutes (NMIs), including National Institute of Standards and Technology (NIST), Physikalisch-Technische Bundesanstalt (PTB), Czech Metrology Institute (CMI), National Metrology Institute of Japan (NMIJ), Centro Nacional de Metrología (CENAM), and DI Mendeleyev Institute for Metrology (VNIIM). The comparison was made via a calibrated transfer standard measured at each of the NMIs facilities using their laboratory standard during the period May 2012 to September 2013...
2017: Metrologia
https://www.readbyqxmd.com/read/28216572/in-vitro-characterization-of-the-two-stage-non-classical-reassembly-pathway-of-s-layers
#2
Andreas Breitwieser, Jagoba Iturri, Jose-Luis Toca-Herrera, Uwe B Sleytr, Dietmar Pum
The recombinant bacterial surface layer (S-layer) protein rSbpA of Lysinibacillus sphaericus CCM 2177 is an ideal model system to study non-classical nucleation and growth of protein crystals at surfaces since the recrystallization process may be separated into two distinct steps: (i) adsorption of S-layer protein monomers on silicon surfaces is completed within 5 min and the amount of bound S-layer protein sufficient for the subsequent formation of a closed crystalline monolayer; (ii) the recrystallization process is triggered-after washing away the unbound S-layer protein-by the addition of a CaCl₂ containing buffer solution, and completed after approximately 2 h...
February 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28215120/strategies-and-actions-of-multi-purpose-health-communication-on-vaccine-preventable-infectious-diseases-in-order-to-increase-vaccination-coverage-in-the-population-the-esculapio-project
#3
Angela Bechini, Paolo Bonanni, Sara Lauri, Emilia Tiscione, Miriam Levi, Rosa Prato, Francesca Fortunato, Domenico Martinelli, Roberto Gasparini, Donatella Panatto, Daniela Amicizia, Rosa Cristina Coppola, Barbara Pellizzari, Garden Tabacchi, Claudio Costantino, Francesco Vitale, Stefania Iannazzo, Sara Boccalini
The ESCULAPIO Project aims at increasing awareness on vaccine preventable infectious diseases (VPID) and vaccinations in different target populations and to spread the culture of prevention. Information/training interventions on VPID have been developed and health promotion activities for the general population, students and their parents, teachers and health care workers (HCWs) were set up. In Tuscany, educational courses on VPID in high schools were organized and students were stimulated to prepare informative materials on VPID for lower grade school pupils...
February 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28212190/endothelial-cell-disease-emerging-knowledge-from-cerebral-cavernous-malformations
#4
Maria Grazia Lampugnani, Matteo Malinverno, Elisabetta Dejana
PURPOSE OF REVIEW: Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous microvessels of the central nervous system and which is caused by loss-of-function mutation in any one of the three CCM genes (CCM1, 2 or 3) in endothelial cells. The phenotypic result of these mutations are focal vascular malformations that are permeable and fragile causing neurological symptoms and occasionally haemorrhagic stroke...
February 16, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28210351/cross-continuum-tool-is-associated-with-reduced-utilization-and-cost-for-frequent-high-need-users
#5
Lauran Hardin, Adam Kilian, Leslie Muller, Kevin Callison, Michael Olgren
INTRODUCTION: High-need, high-cost (HNHC) patients can over-use acute care services, a pattern of behavior associated with many poor outcomes that disproportionately contributes to increased U.S. healthcare cost. Our objective was to reduce healthcare cost and improve outcomes by optimizing the system of care. We targeted HNHC patients and identified root causes of frequent healthcare utilization. We developed a cross-continuum intervention process and a succinct tool called a Complex Care Map (CCM)© that addresses fragmentation in the system and links providers to a comprehensive individualized analysis of the patient story and causes for frequent access to health services...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28196943/association-between-community-management-of-pneumonia-and-diarrhoea-in-high-burden-countries-and-the-decline-in-under-five-mortality-rates-an-ecological-analysis
#6
Cynthia Boschi-Pinto, Thandassery Ramachandran Dilip, Anthony Costello
OBJECTIVE: The objective of the paper is to explore if the adoption of national policies to use community-based health providers for the management of pneumonia and diarrhoea is associated with the decline in under-five mortality, including achievement of the Millennium Development Goal (MDG)4 target, in high-burden countries. SETTING: This country level analysis covers 75 high-burden low-income and middle-income countries which accounted for 98% of the 5.9 million global under-five deaths in 2015...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28192486/ocean-acidification-modulates-expression-of-genes-and-physiological-performance-of-a-marine-diatom
#7
Yahe Li, Shufang Zhuang, Yaping Wu, Honglin Ren, Fangyi Chen, Xin Lin, Kejian Wang, John Beardall, Kunshan Gao
Ocean Acidification (OA) is known to affect various aspects of physiological performances of diatoms, but little is known about the underlining molecular mechanisms involved. Here, we show that in the model diatom Phaeodactylum tricornutum, the expression of key genes associated with photosynthetic light harvesting as well as those encoding Rubisco, carbonic anhydrase, NADH dehydrogenase and nitrite reductase, are modulated by OA (1000 μatm, pHnbs 7.83). Growth and photosynthetic carbon fixation were enhanced by elevated CO2...
2017: PloS One
https://www.readbyqxmd.com/read/28188644/rnai-based-targeted-gene-knockdown-in-the-model-oleaginous-microalgae-nannochloropsis-oceanica
#8
Li Wei, Yi Xin, Qintao Wang, Juan Yang, Hanhua Hu, Jian Xu
Microalgae are promising feedstock for renewable fuels such as biodiesel, yet development of industrial oleaginous strains has been hindered by the paucity and inefficiency of reverse genetics tools. Here we established an efficient RNAi-based targeted gene-knockdown method for Nannochloropsis spp., which are emerging model organisms for industrial microalgal oil production. The method achieved a 40-80% success rate in Nannochloropsis oceanica strain IMET1. When transcript level of one carbonic anhydrase (CA) was inhibited by 62-83% via RNAi, mutant cells exhibited photosynthetic oxygen evolution (POE) rates that were 68-100% higher than wild-type (WT) at pH 6...
November 7, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28181560/responses-of-the-marine-diatom-thalassiosira-pseudonana-to-changes-in-co2-concentration-a-proteomic-approach
#9
Romain Clement, Sabrina Lignon, Pascal Mansuelle, Erik Jensen, Matthieu Pophillat, Regine Lebrun, Yann Denis, Carine Puppo, Stephen C Maberly, Brigitte Gontero
The concentration of CO2 in many aquatic systems is variable, often lower than the KM of the primary carboxylating enzyme Rubisco, and in order to photosynthesize efficiently, many algae operate a facultative CO2 concentrating mechanism (CCM). Here we measured the responses of a marine diatom, Thalassiosira pseudonana, to high and low concentrations of CO2 at the level of transcripts, proteins and enzyme activity. Low CO2 caused many metabolic pathways to be remodeled. Carbon acquisition enzymes, primarily carbonic anhydrase, stress, degradation and signaling proteins were more abundant while proteins associated with nitrogen metabolism, energy production and chaperones were less abundant...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28181149/genome-wide-sequencing-reveals-micrornas-downregulated-in-cerebral-cavernous-malformations
#10
Souvik Kar, Kiran Kumar Bali, Arpita Baisantry, Robert Geffers, Amir Samii, Helmut Bertalanffy
Cerebral cavernous malformations (CCM) are vascular lesions associated with loss-of-function mutations in one of the three genes encoding KRIT1 (CCM1), CCM2, and PDCD10. Recent understanding of the molecular mechanisms that lead to CCM development is limited. The role of microRNAs (miRNAs) has been demonstrated in vascular pathologies resulting in loss of tight junction proteins, increased vascular permeability and endothelial cell dysfunction. Since the relevance of miRNAs in CCM pathophysiology has not been elucidated, the primary aim of the study was to identify the miRNA-mRNA expression network associated with CCM...
February 8, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28166784/randomized-controlled-trial-of-a-coordinated-care-intervention-to-improve-risk-factor-control-after-stroke-or-transient-ischemic-attack-in-the-safety-net-secondary-stroke-prevention-by-uniting-community-and-chronic-care-model-teams-early-to-end-disparities
#11
Amytis Towfighi, Eric M Cheng, Monica Ayala-Rivera, Heather McCreath, Nerses Sanossian, Tara Dutta, Bijal Mehta, Robert Bryg, Neal Rao, Shlee Song, Ali Razmara, Magaly Ramirez, Theresa Sivers-Teixeira, Jamie Tran, Elizabeth Mojarro-Huang, Ana Montoya, Marilyn Corrales, Beatrice Martinez, Phyllis Willis, Mireya Macias, Nancy Ibrahim, Shinyi Wu, Jeremy Wacksman, Hilary Haber, Adam Richards, Frances Barry, Valerie Hill, Brian Mittman, William Cunningham, Honghu Liu, David A Ganz, Diane Factor, Barbara G Vickrey
BACKGROUND: Recurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. However, vascular risk factor control is frequently poor among stroke survivors, particularly among socio-economically disadvantaged blacks, Latinos and other people of color. The Chronic Care Model (CCM) is an effective framework for multi-component interventions aimed at improving care processes and outcomes for individuals with chronic disease...
February 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28160210/a-novel-krit1-ccm1-gene-insertion-mutation-associated-with-cerebral-cavernous-malformations-in-a-chinese-family
#12
Hui Wang, Yunzhu Pan, Zaiqiang Zhang, Xingang Li, Zhe Xu, Yue Suo, Wei Li, Yongjun Wang
Familial cerebral cavernous malformation (FCCM) is a vascular malformation disorder that closely associated with three identified genes: KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3. Here, we present a Chinese family affected by FCCM due to a novel KRIT1/CCM1 insertion mutation. The proband was hospitalized for sudden unconsciousness and underwent surgical treatment. The section of lesions showed classical cavernous-dilated vessels without intervening brain parenchyma, and hemosiderin-laden macrophages were accumulated in the surrounding tissue...
February 3, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28141930/value-based-payment-in-implementing-evidence-based-care-the-mental-health-integration-program-in-washington-state
#13
Yuhua Bao, Thomas G McGuire, Ya-Fen Chan, Ashley A Eggman, Andrew M Ryan, Martha L Bruce, Harold Alan Pincus, Erin Hafer, Jürgen Unützer
OBJECTIVES: To assess the role of value-based payment (VBP) in improving fidelity and patient outcomes in community implementation of an evidence-based mental health intervention, the Collaborative Care Model (CCM). STUDY DESIGN: Retrospective study based on a natural experiment. METHODS: We used the clinical tracking data of 1806 adult patients enrolled in a large implementation of the CCM in community health clinics in Washington state. VBP was initiated in year 2 of the program, creating a natural experiment...
January 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28141483/pontibacter-aurantiacus-sp-nov-isolated-from-hexachlorocyclohexane-hch-contaminated-soil
#14
Priya Singh, Rashmi Kumari, Namita Nayyar, Rup Lal
Strain NP1T, a Gram-stain negative, orange-coloured, rod-shaped bacterium was isolated from hexacholorocyclohexane (HCH) contaminated soil sediment collected from Ummari village, Lucknow, Uttar Pradesh, India. The 16S rRNA gene sequence analysis showed that strain NP1T clustered with members belonging to the genus Pontibacter of the order Cytophagales, family Cytophagaceae and phylum Bacteriodetes. The 16S rRNA gene sequence similarity with type strains of the genus Pontibacter ranged from 98.57 to 93.95% depicting Pontibacter odishensis JC-130T (98...
January 28, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28131879/heterologous-expression-of-halomonas-halodenitrificans-nitric-oxide-reductase-and-its-n-terminally-truncated-norc-subunit-in-escherichia-coli
#15
Nobuhiko Sakurai, Kunishige Kataoka, Noriko Sugaya, Takaki Shimodaira, Mie Iwamoto, Munehiro Shoda, Hajime Horiuchi, Miyuki Kiyono, Yasuke Ohta, Bambang Triwiyono, Daisuke Seo, Takeshi Sakurai
Halomonas halodenitrificans nitric oxide reductase (NOR) is the membrane-bound heterodimer complex of NorC, which contains a low-spin heme c center, and NorB, which contains a low-spin heme b center, a high-spin heme b3 center, and a non-heme FeB center. The soluble domain of NorC, NorC* (ΔMet1-Val37) was heterologously expressed in Escherichia coli using expression plasmids harboring the truncated norC gene deleted of its 84 5'-terminal nucleotides. Analogous scission of the N-terminal helix as the membrane anchor took place when the whole norC gene was used...
January 21, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28128221/detecting-the-causality-influence-of-individual-meteorological-factors-on-local-pm2-5-concentration-in-the-jing-jin-ji-region
#16
Ziyue Chen, Jun Cai, Bingbo Gao, Bing Xu, Shuang Dai, Bin He, Xiaoming Xie
Due to complicated interactions in the atmospheric environment, quantifying the influence of individual meteorological factors on local PM2.5 concentration remains challenging. The Beijing-Tianjin-Hebei (short for Jing-Jin-Ji) region is infamous for its serious air pollution. To improve regional air quality, characteristics and meteorological driving forces for PM2.5 concentration should be better understood. This research examined seasonal variations of PM2.5 concentration within the Jing-Jin-Ji region and extracted meteorological factors strongly correlated with local PM2...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28116327/constitutional-de-novo-and-postzygotic-mutations-in-isolated-cases-of-cerebral-cavernous-malformations
#17
Matthias Rath, Stefanie Spiegler, Neetika Nath, Konrad Schwefel, Nataliya Di Donato, Johannes Gerber, G Christoph Korenke, Yorck Hellenbroich, Ute Hehr, Stephanie Gross, Ulrich Sure, Barbara Zoll, Eberhard Gilberg, Lars Kaderali, Ute Felbor
BACKGROUND: Cerebral cavernous malformations (CCM) are vascular lesions of the central nervous system that can be found in sporadic or autosomal dominantly inherited forms and manifest with headaches, seizures, and hemorrhagic stroke. The precise proportion of de novo mutations in the CCM1,CCM2, and CCM3 genes remains unknown. METHODS: We here present a series of six trios with de novo mutations that have been analyzed by amplicon deep sequencing to differentiate between constitutional and postzygotic mutations...
January 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28115547/proteomic-and-mutant-analysis-of-the-co2-concentrating-mechanism-of-hydrothermal-vent-chemolithoautotroph-thiomicrospira-crunogena
#18
Mary Mangiapia, Terry-René W Brown, Dale Chaput, Edward Haller, Tara L Harmer, Zahra Hashemy, Ryan Keeley, Juliana Leonard, Paola Mancera, David Nicholson, Stanley Stevens, Pauline Wanjugi, Tania Zabinski, Chongle Pan, Kathleen M Scott
: Many autotrophic microorganisms are likely to adapt to scarcity in dissolved inorganic carbon (DIC; = CO2 + HCO3(-) + CO3(2-)) with CO2 concentrating mechanisms (CCM) which actively transport DIC across the cell membrane to facilitate carbon fixation. Surprisingly, DIC transport has only been well-studied among cyanobacteria and microalgae. Deep-sea vent gammaproteobacterial chemolithoautotroph Thiomicrospira crunogena has a low-DIC inducible CCM, though the mechanism for uptake is unclear, as homologs to cyanobacterial transporters are absent...
January 23, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28113425/connected-component-model-for-multi-object-tracking
#19
Dacheng Tao, Xin Li, Zhenyu He, Xinge You, Yuan Y Tang
In multi-object tracking, it is critical to explore the data associations by exploiting the temporal information from a sequence of frames rather than the information from the adjacent two frames. Since straightforwardly obtaining data associations from multi-frames is an NP-hard Multi-Dimensional Assignment (MDA) problem, most existing methods solve this MDA problem by either developing complicated approximate algorithms, or simplifying MDA as a two-dimensional assignment problem based upon the information extracted only from adjacent frames...
May 18, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28109324/reporting-of-critical-care-trial-abstracts-a-comparison-before-and-after-the-announcement-of-consort-guideline-for-abstracts
#20
Akira Kuriyama, Naomi Takahashi, Takeo Nakayama
BACKGROUND: An extension of the Consolidated Standards of Reporting Trials (CONSORT) statement provides a checklist of items to improve the reporting quality of abstracts of randomized controlled trials (RCTs). However, authors of abstracts in some fields have poorly adhered to this guideline. We did an extensive literature survey to examine the quality of reporting trial abstracts in major critical care journals before and after announcement of the CONSORT guideline for abstracts. METHODS: We reviewed abstracts of RCTs published in four major critical care journals with publication dates ranging from 2006 to 2007 (pre-CONSORT) and from 2011 to 2012 (post-CONSORT): Intensive Care Medicine (ICM), Critical Care (CC), American Journal of Respiratory and Critical Care Medicine (AJRCCM), and Critical Care Medicine (CCM)...
January 21, 2017: Trials
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