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Jiong Li, Xuandong Wang, Dongye Zheng, Xinyi Lin, Zuwu Wei, Da Zhang, Zhuanfang Li, Yun Zhang, Ming Wu, Xiaolong Liu
Theranostic nanoprobes integrated with dual-modal imaging and therapeutic functions, such as photodynamic therapy (PDT), have exhibited significant potency in cancer treatments due to their high imaging accuracy and non-invasive advantages for cancer elimination. However, biocompatibility and highly efficient accumulation of these nanoprobes in tumor are still unsatisfactory for clinical application. In this study, a photosensitizer -loaded magnetic nanobead with surface further coated with a layer of cancer cell membrane (SSAP-Ce6@CCM) was designed to improve the biocompatibility and cellular uptake and ultimately achieve enhanced MR/NIR fluorescence imaging and PDT efficacy...
May 22, 2018: Biomaterials Science
Merit P George, Gregory M Garrison, Zachary Merten, Dagoberto Heredia, Cesar Gonzales, Kurt B Angstman
BACKGROUND: Previous studies have suggested that having a comorbid personality disorder (PD) along with major depression is associated with poorer depression outcomes relative to those without comorbid PD. However, few studies have examined the influence of specific PD cluster types. The purpose of the current study is to compare depression outcomes between cluster A, cluster B, and cluster C PD patients treated within a collaborative care management (CCM), relative to CCM patients without a PD diagnosis...
January 2018: Journal of Primary Care & Community Health
Lee Ling Lim, Eric S H Lau, Alice P S Kong, Melanie J Davies, Naomi S Levitt, Björn Eliasson, Carlos A Aguilar-Salinas, Guang Ning, Yutaka Seino, Wing Yee So, Margaret McGill, Graham D Ogle, Trevor J Orchard, Philip Clarke, Rury R Holman, Edward W Gregg, Juan José Gagliardino, Juliana C N Chan
OBJECTIVE: The implementation of the Chronic Care Model (CCM) improves health care quality. We examined the sustained effectiveness of multicomponent integrated care in type 2 diabetes. RESEARCH DESIGN AND METHODS: We searched PubMed and Ovid MEDLINE (January 2000-August 2016) and identified randomized controlled trials comprising two or more quality improvement strategies from two or more domains (health system, health care providers, or patients) lasting ≥12 months with one or more clinical outcomes...
June 2018: Diabetes Care
Tobias G Boatman, Kevin Oxborough, Martha Gledhill, Tracy Lawson, Richard J Geider
We have assessed how varying CO2 (180, 380, and 720 μatm) and growth light intensity (40 and 400 μmol photons m-2 s-1 ) affected Trichodesmium erythraeum IMS101 growth and photophysiology over free iron (Fe') concentrations between 20 and 9,600 pM. We found significant iron dependencies of growth rate and the initial slope and maximal relative PSII electron transport rates (rPm ). Under iron-limiting concentrations, high-light increased growth rates and rPm ; possibly indicating a lower allocation of resources to iron-containing photosynthetic proteins...
2018: Frontiers in Microbiology
William T Abraham, Karl-Heinz Kuck, Rochelle L Goldsmith, JoAnn Lindenfeld, Vivek Y Reddy, Peter E Carson, Douglas L Mann, Benjamin Saville, Helen Parise, Rodrigo Chan, Phi Wiegn, Jeffrey L Hastings, Andrew J Kaplan, Frank Edelmann, Lars Luthje, Rami Kahwash, Gery F Tomassoni, David D Gutterman, Angela Stagg, Daniel Burkhoff, Gerd Hasenfuß
OBJECTIVES: The authors sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUND: CCM therapy for New York Heart Association (NYHA) functional class III and IV heart failure (HF) patients consists of nonexcitatory electrical signals delivered to the heart during the absolute refractory period...
May 5, 2018: JACC. Heart Failure
Charlotte Poschenrieder, José Antonio Fernández, Lourdes Rubio, Laura Pérez, Joana Terés, Juan Barceló
Bicarbonate plays a fundamental role in the cell pH status in all organisms. In autotrophs, HCO₃− may further contribute to carbon concentration mechanisms (CCM). This is especially relevant in the CO₂-poor habitats of cyanobacteria, aquatic microalgae, and macrophytes. Photosynthesis of terrestrial plants can also benefit from CCM as evidenced by the evolution of C₄ and Crassulacean Acid Metabolism (CAM). The presence of HCO₃− in all organisms leads to more questions regarding the mechanisms of uptake and membrane transport in these different biological systems...
May 3, 2018: International Journal of Molecular Sciences
Stephan Allgeier, Andreas Bartschat, Sebastian Bohn, Sabine Peschel, Klaus-Martin Reichert, Karsten Sperlich, Marcus Walckling, Veit Hagenmeyer, Ralf Mikut, Oliver Stachs, Bernd Köhler
The capability of corneal confocal microscopy (CCM) to acquire high-resolution in vivo images of the densely innervated human cornea has gained considerable interest in using this non-invasive technique as an objective diagnostic tool for staging peripheral neuropathies. Morphological alterations of the corneal subbasal nerve plexus (SNP) assessed by CCM have been shown to correlate well with the progression of neuropathic diseases and even predict future-incident neuropathy. Since the field of view of single CCM images is insufficient for reliable characterisation of nerve morphology, several image mosaicking techniques have been developed to facilitate the assessment of the SNP in large-area visualisations...
May 10, 2018: Scientific Reports
D Duncker, C Veltmann
In patients with heart failure with reduced ejection fraction (HFrEF), optimal medical treatment includes beta-blockers, ACE inhibitors/angiotensinreceptor-neprilysin inhibitors (ARNI), mineralocorticoid receptor antagonists, and ivabradine when indicated. In device therapy of HFrEF, implantable cardioverter-defibrillators and cardiac resynchronization therapy (CRT) have been established for many years. CRT is the therapy of choice (class I indication) in symptomatic patients with HFrEF and a broad QRS complex with a left bundle branch block (LBBB) morphology...
May 9, 2018: Herz
J M A Alcantara, G Sanchez-Delgado, B Martinez-Tellez, E Merchan-Ramirez, I Labayen, J R Ruiz
BACKGROUND & AIMS: Achieving high inter-day reliability is a key factor to analyze the magnitude of change in RMR, for instance after an intervention. The aims of this study were: i) to determine the congruent validity of RMR and respiratory quotient (RQ) with two breath by breath commercially available metabolic carts [CCM Express (CCM) and Ultima CardiO2 (MGU)]; and ii) to analyze the inter-day reliability of RMR and RQ measurements. METHODS & RESULTS: Seventeen young adults participated in the study...
March 30, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Rafael Borge, Jose Luis Santiago, David de la Paz, Fernando Martín, Jessica Domingo, Cristina Valdés, Beatriz Sánchez, Esther Rivas, Mª Teresa Rozas, Sonia Lázaro, Javier Pérez, Álvaro Fernández
Air pollution continues to be one of the main issues in urban areas. In addition to air quality plans and emission abatement policies, additional measures for high pollution episodes are needed to avoid exceedances of hourly limit values under unfavourable meteorological conditions such as the Madrid's short-term action NO2 protocol. In December 2016 there was a strong atmospheric stability episode that turned out in generalized high NO2 levels, causing the stage 3 of the NO2 protocol to be triggered for the first time in Madrid (29th December)...
May 5, 2018: Science of the Total Environment
Jeremy J Solberg, Mark E Deyo-Svendsen, Kelsey R Nylander, Elliot J Bruhl, Dagoberto Heredia, Kurt B Angstman
BACKGROUND: The use of a collaborative care management (CCM) model can dramatically improve short- and long-term treatment outcomes for patients with major depressive disorder (MDD). Patients with comorbid personality disorder (PD) may experience poorer treatment outcomes for MDD. Our study seeks to examine the differences in MDD treatment outcomes for patients with comorbid PD when using a CCM approach rather than usual care (UC). METHODS: In our retrospective cohort study, we reviewed the records of 9614 adult patients enrolled in our depression registry with the clinical diagnosis MDD and the diagnosis of PD (Yes/No)...
January 2018: Journal of Primary Care & Community Health
Khaled A Selim, Florian Haase, Marcus D Hartmann, Martin Hagemann, Karl Forchhammer
Cyanobacteria are phototrophic prokaryotes that evolved oxygenic photosynthesis ∼2.7 billion y ago and are presently responsible for ∼10% of total global photosynthetic production. To cope with the evolutionary pressure of dropping ambient CO2 concentrations, they evolved a CO2 -concentrating mechanism (CCM) to augment intracellular inorganic carbon (Ci ) levels for efficient CO2 fixation. However, how cyanobacteria sense the fluctuation in Ci is poorly understood. Here we present biochemical, structural, and physiological insights into SbtB, a unique PII -like signaling protein, which provides new insights into Ci sensing...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
Romuald Girard, Hussein A Zeineddine, Janne Koskimaki, Maged D Fam, Ying Cao, Changbin Shi, Thomas J Moore, Rhonda Lightle, Agnieszka Stadnik, Kiranj K Chaudager, Sean P Polster, Robert Shenkar, Ryan C Duggan, David Leclerc, Kevin J Whitehead, Dean Li, Issam A Awad
<u>Rationale:</u> The clinical course of cerebral cavernous malformations (CCMs) is highly unpredictable, with few cross-sectional studies correlating pro-inflammatory genotypes and plasma biomarkers with prior disease severity. <u>Objective:</u> We hypothesize that a panel of 24 candidate plasma biomarkers, with a reported role in the physiopathology of CCMs, may predict subsequent clinically relevant disease activity. <u>Methods and Results:</u> Plasma biomarkers were assessed in non-fasting peripheral venous blood collected from consecutive CCM subjects followed for one year after initial sample collection...
May 2, 2018: Circulation Research
Quan Wei, Karen L Courtney
OBJECTIVE:  Long-term care (LTC), residential care requiring 24-hour nursing services, plays an important role in the health care service delivery system. The purpose of this study was to identify the needed clinical information and information flow to support LTC Registered Nurses (RNs) in care collaboration and clinical decision making. METHODS:  This descriptive qualitative study combines direct observations and semistructured interviews, conducted at Alberta's LTC facilities between May 2014 and August 2015...
April 2018: Applied Clinical Informatics
Susanne Röger, Boris Rudic, Ibrahim Akin, Tetyana Shchetynska-Marinova, Fabian Fastenrath, Erol Tülümen, Volker Liebe, Ibrahim El-Battrawy, Stefan Baumann, Jürgen Kuschyk, Martin Borggrefe
BACKGROUND: Cardiac contractility modulation (CCM) is an electrical-device therapy for patients with heart failure with reduced ejection fraction (HFrEF). Patients with left ventricular ejection fraction (LVEF) ≤35% also have indication for an implantable cardioverter-defibrillator (ICD), and in some cases subcutaneous ICD (S-ICD) is selected. HYPOTHESIS: CCM and S-ICD can be combined to work efficaciously and safely. METHODS: We report on 20 patients with HFrEF and LVEF ≤35% who received CCM and S-ICD...
April 26, 2018: Clinical Cardiology
Daniel J Minter, Sean D Levy, Sowmya R Rao, Paul F Currier
Background: The United States (US) is experiencing a growing shortage of critical care medicine (CCM) trained physicians. Little is known about the exposures to CCM experienced by internal medicine (IM) residents or factors that may influence their decision to pursue a career in pulmonary/critical care medicine (PCCM). Methods: We conducted a survey of US IM residency program directors (PDs) and then used multivariable logistic regression to identify factors that were predictive of residency programs with a higher percentage of graduates pursuing careers in PCCM...
2018: Critical Care Research and Practice
Bingqian Lei, Mengfan Wang, Zelei Jiang, Wei Qi, Rongxin Su, Zhimin He
Metal-organic frameworks (MOFs), which are a unique class of hybrid porous materials built from metal ions and organic ligands, have attracted significant interest in recent years as a promising platform for controlled drug delivery. Current approaches for creating MOFs-based responsive drug carriers involve encapsulation of stimuli-responsive compositions into MOFs or post-synthetic surface modification with sensitive molecules. In this study, we developed a novel intrinsic redox-responsive MOFs carrier, MOF-M(DTBA) (M= Fe, Al or Zr) by using iron, aluminum or zirconium as metal nodes and 4,4'-dithiobisbenzoic acid (4,4'-DTBA) as the organic ligand...
April 25, 2018: ACS Applied Materials & Interfaces
George L Jackson, Karen M Stechuchak, Morris Weinberger, Hayden B Bosworth, Cynthia J Coffman, Miriam A Kirshner, David Edelman
INTRODUCTION: We assessed potential racial or ethnic differences in the degree to which veterans with pharmaceutically treated hypertension report experiences with their primary care system that are consistent with optimal chronic illness care as suggested by Wagner's Chronic Care Model (CCM). MATERIALS AND METHODS: A cross-sectional analysis of the results of the Patient Assessment of Chronic Illness Care (PACIC), which measured components of the care system suggested by the CCM and was completed at baseline by participants in a hypertension disease management clinical trial...
April 17, 2018: Military Medicine
Eric W Goolsby, Abigail J Moore, Lillian P Hancock, Jurriaan M De Vos, Erika J Edwards
PREMISE OF THE STUDY: Next-generation sequencing facilitates rapid production of well-sampled phylogenies built from very large genetic data sets, which can then be subsequently exploited to examine the molecular evolution of the genes themselves. We present an evolutionary analysis of 83 gene families (19 containing carbon-concentrating mechanism (CCM) genes, 64 containing non-CCM genes) in the portullugo clade (Caryophyllales), a diverse lineage of mostly arid-adapted plants that contains multiple evolutionary origins of all known photosynthesis types in land plants (C3 , C4 , CAM, C4 -CAM, and various intermediates)...
April 16, 2018: American Journal of Botany
Tobias G Boatman, Niall M Mangan, Tracy Lawson, Richard J Geider
We established the relationship between photosynthetic carbon fixation rates and pH, CO2 and HCO3- concentrations in the diazotroph Trichodesmium erythraeum IMS101. Inorganic 14C-assimilation was measured in TRIS-buffered ASW medium where the absolute and relative concentrations of CO2, pH and HCO3- were manipulated. First, we varied the total dissolved inorganic carbon concentration (TIC) (< 0 to ~ 5 mM) at constant pH, so ratios of CO2 and HCO3- remained relatively constant. Second, we varied pH (~ 8.54 to 7...
April 12, 2018: Journal of Experimental Botany
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