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https://www.readbyqxmd.com/read/28101624/the-safety-and-efficacy-of-cardiac-contractility-modulation-in-heart-failure-a%C3%A2-meta-analysis-of-clinical-trials
#1
X Liu, H J Yang, H Q Ping, S Qiu, S Shi, B Yang
BACKGROUND: Cardiac contractility modulation (CCM) has developed as a promising treatment device for heart failure (HF). This meta-analysis aimed at systematically reviewing the latest available published trials to provide evidence on the safety and efficacy of CCM in patients with HF. METHODS: We searched the Cochrane Central Resister of Controlled Trials, PubMed, and EMBASE in May 2016 to identify eligible clinical trials comparing CCM with sham treatment or with usual care...
January 18, 2017: Herz
https://www.readbyqxmd.com/read/28087183/co-expression-of-tissue-factor-and-il-6-in-immature-endothelial-cells-of-cerebral-cavernous-malformations
#2
Shouhei Noshiro, Takeshi Mikami, Yuko Kataoka-Sasaki, Masanori Sasaki, Hirofumi Ohnishi, Shunya Ohtaki, Masahiko Wanibuchi, Nobuhiro Mikuni, Jeffery D Kocsis, Osamu Honmou
Cerebral cavernous malformations (CCMs) are congenital abnormal clusters of capillaries that are prone to leaking and thought to result from a disorder of endothelial cells. The underlying pathology of CCM is not fully understood. We analyzed the expression of tissue factor (TF) and interleukin-6 (IL-6) in CCMs to determine the association of TF and IL-6 with clinical and pathological findings. Thirteen cases of operative specimens of sporadic CCMs were included in this study. The expression of messenger RNA of TF and IL-6 was assayed and the association with clinical factors was investigated...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28068593/visible-light-induced-crosslinking-and-physiological-stabilization-of-diselenide-rich-nanoparticles-for-redox-responsive-drug-release-and-combination-chemotherapy
#3
Shaodong Zhai, Xianglong Hu, Yongjun Hu, Baoyan Wu, Da Xing
Undesired physiological instability of nanocarriers and premature drug leakage during blood circulation result in compromised therapeutic efficacy and severe side effects, which have significantly impeded the development of nanomedicine. Facile crosslinking of drug-loaded nanocarriers while keeping the potency of site-specific degradation and drug release has emerged as a viable strategy to overcome these drawbacks. Additionally, combination therapy has already shown advantages in inhibiting advanced tumors and life extension than single drug therapy...
January 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28068214/paenibacillus-rhizoplanae-sp-nov-isolated-from-the-rhizosphere-of-zea-mays
#4
Peter Kämpfer, Hans-Jürgen Busse, John A McInroy, Chia-Hui Hu, Joseph W Kloepper, Stefanie P Glaeser
A Gram-positive staining, aerobic, endospore-forming bacterial strain, isolated from the rhizosphere of Zea mays was studied for its detailed taxonomic allocation. Based on 16S rRNA gene sequence similarity comparisons, strain JJ-64T was shown to be a member of the genus Paenibacillus, most closely related to the type strains of Paenibacillus silagei (99%) and Paenibacillus borealis (97.5%). The 16S rRNA gene sequence similarity to all other Paenibacillus species was ≤ 97.5%. DNA-DNA hybridization values to the type strains of P...
January 6, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28067248/deformation-mechanisms-to-ameliorate-the-mechanical-properties-of-novel-trip-twip-co-cr-mo-cu-ultrafine-eutectic-alloys
#5
J T Kim, S H Hong, H J Park, Y S Kim, J Y Suh, J K Lee, J M Park, T Maity, J Eckert, K B Kim
In the present study, the microstructural evolution and the modulation of the mechanical properties have been investigated for a Co-Cr-Mo (CCM) ternary eutectic alloy by addition of a small amount of copper (0.5 and 1 at.%). The microstructural observations reveal a distinct dissimilarity in the eutectic structure such as a broken lamellar structure and a well-aligned lamellar structure and an increasing volume fraction of Co lamellae as increasing amount of copper addition. This microstructural evolution leads to improved plasticity from 1% to 10% without the typical tradeoff between the overall strength and compressive plasticity...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28062941/the-effects-of-ph-and-pco2-on-photosynthesis-and-respiration-in-the-diatom-thalassiosira-weissflogii
#6
Johanna A L Goldman, Michael L Bender, François M M Morel
The response of marine phytoplankton to the ongoing increase in atmospheric pCO2 reflects the consequences of both increased CO2 concentration and decreased pH in surface seawater. In the model diatom Thalassiosira weissflogii, we explored the effects of varying pCO2 and pH, independently and in concert, on photosynthesis and respiration by incubating samples in water enriched in H2(18)O. In long-term experiments (~6-h) at saturating light intensity, we observed no effects of pH or pCO2 on growth rate, photosynthesis or respiration...
January 6, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28056225/xenorhabdus-thuongxuanensis-sp-nov-and-xenorhabdus-eapokensis-sp-nov-isolated-from-steinernema-species
#7
Peter Kämpfer, Nicholas J Tobias, Long Phan Ke, Helge B Bode, Stefanie P Glaeser
Two slightly yellowish pigmented, oxidase-negative, rod-shaped and Gram-negative bacterial strains (30TX1T and DL20T), isolated from Steinernema sangi and Steinernema eapokense, respectively, during soil sampling in Vietnam were studied in a polyphasic taxonomic approach. Strain 30TX1T showed highest 16S rRNA gene sequence similarity to Xenorhabdus ehlersii (98.9%) and strain DL20T to Xenorhabdus ishibashii (98.7%). Sequence similarities to all other Xenorhabdus species were lower (< 98.4%). The two strains shared 98% 16S rRNA gene sequence similarity...
January 4, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28048412/su-c-202-03-a-tool-for-automatic-calculation-of-delivered-dose-variation-for-off-line-adaptive-therapy-using-cone-beam-ct
#8
B Zhang, S Lee, S Chen, J Zhou, K Prado, W D'Souza, B Yi
PURPOSE: Monitoring the delivered dose is an important task for the adaptive radiotherapy (ART) and for determining time to re-plan. A software tool which enables automatic delivered dose calculation using cone-beam CT (CBCT) has been developed and tested. METHODS: The tool consists of four components: a CBCT Colleting Module (CCM), a Plan Registration Moduel (PRM), a Dose Calculation Module (DCM), and an Evaluation and Action Module (EAM). The CCM is triggered periodically (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045311/dental-fear-in-italy-what-is-going-on
#9
L Paglia
If your young patient doesn't feel comfortable and thinks something dreadful is going to happen when he comes to your office, maybe he will develop dental fear. Nowadays, children and teenagers' strong negative emotions related to dental treatment are defined as "Dental Fear and Anxiety" (DFA). Since DFA can result in children's avoidance or delay in undergoing dental visits, this problem represents a relevant social barrier as important as other well-known factors like low family income or parental education...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28044269/under-five-child-mortality-and-morbidity-associated-with-consanguineous-child-marriage-in-pakistan-retrospective-analysis-using-pakistan-demographic-and-health-surveys-1990-91-2006-07-2012-13
#10
Mudasir Mustafa, Rubeena Zakar, Muhammad Zakria Zakar, Ashraf Chaudhry, Muazzam Nasrullah
Objective To assess the combined effect of consanguineous and child marriages (CCM) on children health, which has not previously been explored, either globally or locally. Methods We analyzed secondary data from a series of cross-sectional, nationally representative Pakistan Demographic and Health Surveys 1990-91, 2006-07, and 2012-13. A total of 5406 mothers with 10,164 children were included in the analysis. Child health was assessed by variables such as history of diarrhea, acute respiratory infection (ARI), ARI with fever, Under-5 child mortality (U5CM) and small-size birth (SSB)...
January 2, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28033708/a-simple-combinatorial-codon-mutagenesis-method-for-targeted-protein-engineering
#11
Ketaki D Belsare, Mary C Andorfer, Frida S Cardenas, Julia R Chael, Hyun June Park, Jared C Lewis
Directed evolution is a powerful tool for optimizing enzymes, and mutagenesis methods that improve enzyme library quality can significantly expedite the evolution process. Here, we report a simple method for targeted combinatorial codon mutagenesis (CCM). To demonstrate the utility of this method for protein engineering, CCM libraries were constructed for cytochrome P450BM3, pfu prolyl oligopeptidase, and the flavin-dependent halogenase RebH; 10-26 sites were targeted for codon mutagenesis in each of these enzymes, and libraries with a tunable average of 1-7 codon mutations per gene were generated...
January 4, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28032814/information-sources-and-knowledge-on-vaccination-in-a-population-from-southern-italy-the-esculapio-project
#12
Garden Tabacchi, Claudio Costantino, Manuela Cracchiolo, Antonio Ferro, Valentina Marchese, Giuseppe Napoli, Sara Palmeri, Daniele Raia, Vincenzo Restivo, Andrea Siddu, Francesco Vitale, Alessandra Casuccio
Vaccine knowledge of the general population is shaped by different information sources and strongly influences vaccination attitudes and uptake. The CCM-Italian Ministry of Health ESCULAPIO project attempted to identify the role of such information sources, in order to address adequate strategies to improve information on vaccines and vaccine preventable diseases. In the present study, data on 632 adults from Southern Italy regarding information sources were collected, and their perceived and actual knowledge on vaccinations were compared and analysed in relation to socio-demographic characteristics and information sources...
December 29, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28032540/photorhabdus-luminescens-subsp-namnaonensis-subsp-nov-isolated-from-heterorhabditis-baujardi-nematodes-in-nam-nao-district-of-central-thailand
#13
Stefanie P Glaeser, Nicholas J Tobias, Aunchalee Thanwisai, Narisara Chantratita, Helge B Bode, Peter Kämpfer
A lightly yellowish pigmented, oxidase-negative bacterial strain (PB45.5T), isolated from the Nam Nao district of Phetchabun in central Thailand was investigated for its taxonomic position. The cells morphology of the isolate showed a rod shaped appearance. The strain stained Gram-negative. Strain PB45.5T shared highest 16S rRNA gene sequence similarity with the type strain of Photorhabdus luminescens subsp. akhurstii (99.2%) and Photorhabdus luminescens subsp. hainanensisi (99.1%) and lower similarities to all other Photorhabdus luminescens subspecies (< 98...
December 29, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28030639/limits-to-causal-inference-with-state-space-reconstruction-for-infectious-disease
#14
Sarah Cobey, Edward B Baskerville
Infectious diseases are notorious for their complex dynamics, which make it difficult to fit models to test hypotheses. Methods based on state-space reconstruction have been proposed to infer causal interactions in noisy, nonlinear dynamical systems. These "model-free" methods are collectively known as convergent cross-mapping (CCM). Although CCM has theoretical support, natural systems routinely violate its assumptions. To identify the practical limits of causal inference under CCM, we simulated the dynamics of two pathogen strains with varying interaction strengths...
2016: PloS One
https://www.readbyqxmd.com/read/28018564/evaluation-of-stability-of-interface-between-ccm-co-cr-mo-ucla-abutment-and-external-hex-implant
#15
Ki-Joon Yoon, Young-Bum Park, Hyunmin Choi, Youngsung Cho, Jae-Hoon Lee, Keun-Woo Lee
PURPOSE: The purpose of this study is to evaluate the stability of interface between Co-Cr-Mo (CCM) UCLA abutment and external hex implant. MATERIALS AND METHODS: Sixteen external hex implant fixtures were assigned to two groups (CCM and Gold group) and were embedded in molds using clear acrylic resin. Screw-retained prostheses were constructed using CCM UCLA abutment and Gold UCLA abutment. The external implant fixture and screw-retained prostheses were connected using abutment screws...
December 2016: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28004798/the-dynamic-monitoring-of-aeolian-desertification-land-distribution-and-its-response-to-climate-change-in-northern-china
#16
Lili Feng, Zhiqing Jia, Qingxue Li
Aeolian desertification is poorly understood despite its importance for indicating environment change. Here we exploit Gaofen-1(GF-1) and Moderate Resolution Imaging Spectroradiometer (MODIS) data to develop a quick and efficient method for large scale aeolian desertification dynamic monitoring in northern China. This method, which is based on Normalized Difference Desertification Index (NDDI) calculated by band1 &band2 of MODIS reflectance data (MODIS09A1). Then we analyze spatial-temporal change of aeolian desertification area and detect its possible influencing factors, such as precipitation, temperature, wind speed and population by Convergent Cross Mapping (CCM) model...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28003363/nuclear-localization-of-integrin-cytoplasmic-associated-protein-1-influences-%C3%AE-1-integrin-activation-and-recruits-krev-interaction-trapped-1-to-the-nucleus
#17
Kyle M Draheim, Clotilde Huet-Calderwood, Bertrand Simon, David A Calderwood
Binding of ICAP1 (Integrin Cytoplasmic Associated Protein-1) to the cytoplasmic tails of β1 integrins inhibits integrin activation. ICAP1 also binds to KRIT1 (Krev/Rap1 Interaction Trapped-1), a protein whose loss-of-function leads to cerebral cavernous malformation (CCM), a cerebrovascular dysplasia occurring in up to 0.5% of the population. We previously showed that KRIT1 functions as a switch for β1 integrin activation by antagonizing ICAP1- mediated inhibition of integrin activation. Here we use over-expression studies, mutagenesis, and flow cytometry to show that ICAP1 contains a functional nuclear localization signal (NLS) and that nuclear localization impairs the ability of ICAP1 to suppress integrin activation...
December 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28000143/update-on-novel-ccm-gene-mutations-in-patients-with-cerebral-cavernous-malformations
#18
Concetta Scimone, Placido Bramanti, Concetta Alafaci, Francesca Granata, Francesco Piva, Carmela Rinaldi, Luigi Donato, Federica Greco, Antonina Sidoti, Rosalia D'Angelo
Cerebral cavernous malformations (CCMs) are lesions affecting brain microvessels. The pathogenesis is not clearly understood. Conventional classification criterion is based on genetics, and thus, familial and sporadic forms can be distinguished; however, classification of sporadic cases with multiple lesions still remains uncertain. To date, three CCM causative genes have been identified: CCM1/KRIT1, CCM2/MGC4607 and CCM3/PDCD10. In our previous mutation screening, performed in a cohort of 95 Italian patients, with both sporadic and familial cases, we identified several mutations in CCM genes...
December 20, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27999767/antimicrobial-efficacy-of-the-combination-of-chlorhexidine-digluconate-and-dexpanthenol
#19
Axel Kramer, Ojan Assadian, Torsten Koburger-Janssen
Objective: The objective of this standardised experimental study was to investigate the antimicrobial efficacy of the combination of chlorhexidine digluconate (CHX) and the anti-inflammatory pro-vitamin dexpanthenol, which stimulates wound-healing, in the form of Bepanthen(®) Antiseptic Wound Cream, in order to rule out possible antagonistic combination effects of CHX and the alcohol analogue of pantothenic acid (vitamin B5) dexpanthenol. Method: Testing was carried out using the quantitative suspension test at conditions simulating wound bio-burden...
2016: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/27995868/pedobacter-jamesrossensis-sp-nov-pedobacter-lithocola-sp-nov-pedobacter-mendelii-sp-nov-and-pedobacter-petrophilus-sp-nov-isolated-from-antarctic-environment
#20
Pavel Švec, Stanislava Králová, Hans-Jürgen Busse, Tanita Kleinhagauer, Roman Pantůček, Ivana Mašlaňová, Margo Cnockaert, Peter Vandamme, Eva Staňková, Tereza Gelbíčová, Pavla Holochová, Miloš Barták, Kamila Kýrová, Ivo Sedláček
A taxonomic study performed on 17 Gram-stain-negative rod-shaped bacterial strains originating from Antarctic environment is described. Initial phylogenetic analysis using 16S rRNA gene sequencing differentiated the strains into four groups belonging into the genus Pedobacter but they were separated from all hitherto described Pedobacter spp. Group I (n=8) was closest to Pedobacter aquatilis (97.8 % 16S rRNA gene sequence similarity). Group II (n=2) and group III (n=4) were closely related (98.8 % 16S rRNA gene sequence similarity) and showed Pedobacter jejuensis as their common nearest neighbour...
December 20, 2016: International Journal of Systematic and Evolutionary Microbiology
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