keyword
https://read.qxmd.com/read/38045378/intrinsic-self-organization-of-integrin-nanoclusters-within-focal-adhesions-is-required-for-cellular-mechanotransduction
#21
Kashish Jain, Kyna Yu En Lim, Michael P Sheetz, Pakorn Kanchanawong, Rishita Changede
Upon interaction with the extracellular matrix, the integrin receptors form nanoclusters as a first biochemical response to ligand binding. Here, we uncover a critical biodesign principle where these nanoclusters are spatially self-organized, facilitating effective mechanotransduction. Mouse Embryonic Fibroblasts (MEFs) with integrin β3 nanoclusters organized themselves with an intercluster distance of ∼550 nm on uniformly coated fibronectin substrates, leading to larger focal adhesions. We determined that this spatial organization was driven by cell-intrinsic factors since there was no pre-existing pattern on the substrates...
November 20, 2023: bioRxiv
https://read.qxmd.com/read/38005189/new-sustainable-solvent-extraction-pathways-for-rare-earth-metals-via-oximes-molecules
#22
JOURNAL ARTICLE
Maria Atanassova, Rositsa Kukeva, Vanya Kurteva
A study on the synergistic extraction of Eu(III) ions with a series of chelating ligands and determination of the process parameters is presented by employing ionic liquids and typical organic diluents. The investigations of the liquid-liquid extraction, commonly applied in the separation science of 4f and 5f-ions acidic chelating compounds, 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one (HP), 4-benzoyl-3-phenyl-5-isoxazolone (HPBI), and 2-thenoyltrifluoroacetone (HTTA) alone and in combination with two synergistic agents, meso -hexamethylpropyleneamine oxime (S2: HM-PAO) and its bis-imine precursor (S1: pre-HM-PAO), are presented...
November 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37994470/transcriptome-profile-of-subsynaptic-myonuclei-at-the-neuromuscular-junction-in-embryogenesis
#23
JOURNAL ARTICLE
Bisei Ohkawara, Masaomi Kurokawa, Akinori Kanai, Kiyomi Imamura, Guiying Chen, Ruchen Zhang, Akio Masuda, Koichi Higashi, Hiroshi Mori, Yutaka Suzuki, Ken Kurokawa, Kinji Ohno
Skeletal muscle fiber is a large syncytium with multiple and evenly distributed nuclei. Adult subsynaptic myonuclei beneath the neuromuscular junction (NMJ) express specific genes, the products of which coordinately function in the maintenance of the pre- and post-synaptic regions. However, the gene expression profiles that promote the NMJ formation during embryogenesis remain largely unexplored. We performed single-nucleus RNA sequencing (snRNA-seq) analysis of embryonic and neonatal mouse diaphragms, and found that each myonucleus had a distinct transcriptome pattern during the NMJ formation...
November 23, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/37977793/a-single-site-porphyrin-cu-based-cof-electrocatalyst-for-the-electrochemical-detection-of-gallic-acid-sensitively
#24
JOURNAL ARTICLE
Mei-Jie Wei, Jing Li, Ze-Qi Wei, Sheng-Feng Zhang, Zhong-Xia Wang, Heng-Ye Li, Rui Zhang, Fen-Ying Kong, Wei Wang
Sensitive and convenient determination of gallic acid (GA) is vital for food safety. Here, a novel porphyrin (Cu)-based covalent organic framework named as COF(Cu) was successfully synthesized by condensing pre-metalated 5,10,15,20-tetrakis (para-aminophenyl) porphyrin copper (II) and 2,3,6,7-tetra (4-formylphenyl) tetrathiafulvalene ligands. By combining the advantages of porphyrin with tetrathiafulvalene, it may be possible to create a COF with an intrinsically effective charge-transfer channel. In addition, the Cu-N4 type in the COF(Cu) can be regarded as the single-site electrocatalyst...
December 1, 2023: Analytica Chimica Acta
https://read.qxmd.com/read/37956725/pyrogallol-based-dipodal-optical-probe-as-new-smart-analytical-tool-for-sustainable-detection-of-cobalt-in-biosystem
#25
JOURNAL ARTICLE
Vijay Dangi, Jyoti Kandhal, Amit Gupta, Minati Baral, B K Kanungo
The present research focuses on the micro-level detection of cobalt ions in biological and environmental samples using a new probe. The probe is a multifunctional symmetrical dipodal molecule with two pyrogallol binding units attached to the malonate scaffold through a propylene spacer. It was synthesized and characterized by 1 H NMR, 13 C NMR, IR, electronic spectroscopy, and mass spectrometry. The molecule's binding, thermodynamic, and photophysical properties are also described. The designed probe demonstrates an excellent sensing ability for Co(II) based on the ESIPT "OFF-ON" fluorescence mechanism...
November 11, 2023: Methods: a Companion to Methods in Enzymology
https://read.qxmd.com/read/37948325/is-reaction-acceleration-of-microdroplet-chemistry-favorable-to-controlling-the-enantioselectivity
#26
JOURNAL ARTICLE
Boyu Zheng, Yikang Wu, Luyun Xue, Jiannan Sun, Jinhua Liu, Heyong Cheng
Microdroplet chemistry has been proven to amazingly accelerate many chemical and biological reactions in the past 2 decades. Current microdroplet accelerated reactions are predominantly symmetric synthetic but minorly asymmetric synthetic reactions, where stereoselectivity is scarcely concerned. This study selected unimolecular and bimolecular reactions, multicomponent Passerini reactions, and enzymatic ketone reduction as the model reactions to illustrate whether reaction acceleration of microdroplet chemistry is favorable to retaining a chiral center and controlling the enantioselectivity or not...
November 10, 2023: Journal of Organic Chemistry
https://read.qxmd.com/read/37944371/a-novel-bimetallic-organic-framework-catalyst-induced-by-dual-ligand-for-highly-efficient-oxygen-evolution
#27
JOURNAL ARTICLE
Long Ma, Qi Xue, Yuan Dang, Li Wang, Yuanzhen Zhou
With the continuous advancement of non-noble electrocatalysts, metal-organic frameworks (MOFs) are emerging as a promising substitute for noble metal nanomaterials in oxygen evolution reaction (OER) due to their larger pre-development and higher cost-effectiveness. However, there are still challenges in modifying the electronic structure of MOFs at the molecular level to enhance their activity of OER. Herein, bimetallic CoNi MOFs were utilized and modified with terephthalic acid (A) and 2, 5-dihydroxyterephthalic acid (B) (A2...
November 3, 2023: Journal of Colloid and Interface Science
https://read.qxmd.com/read/37939547/analysis-of-platinum-based-anticancer-injections-cisplatin-and-carboplatin-in-blood-serum-and-urine-of-cancer-patients-by-photometry-fluorometry-liquid-chromatography-using-a-schiff-base-as-derivatizing-reagent
#28
JOURNAL ARTICLE
Faiz Muhammad Khokhar, Taj Muhammad Jahangir, Muhammad Yar Khuhawar, Mazhar Iqbal Khaskheli, Laeeq Ahmed Khokhar, Muhammad Ilyas Abro, Murad Ali Khaskheli, Pirh Muqaddisa
Photometric, fluorometric and liquid chromatographic methods were proposed to analyze Pt(II) from cis-platin and carbo-platin injections after derivatization with reagent 2-oxo-propanoic acid N-phenylhydrazonecarbothioamide. The reagent reacted with metals Au(III), Ag(I), Mn(II), Pt(II), Mo(VI), V(V/IV) to develop their characteristic colors in the pH range 3-12 and were extracted in organic solvent trichloromethane. The photoluminescent behavior of ligand and its metal complexes was investigated to correlate the emission pattern...
October 26, 2023: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/37926164/unleashing-the-room-temperature-boronization-blooming-of-ni-zif-nanobuds-for-efficient-photo-electro-catalysis-of-water
#29
JOURNAL ARTICLE
George John, S Priyadarshini, Anandha Babu, Harshavardhan Mohan, Byung-Taek Oh, M Navaneethan, P Justin Jesuraj
Water splitting provides an environmental-friendly and sustainable approach for generating hydrogen fuel. The inherent energetic barrier in two-core half reactions such as the Hydrogen Evolution Reaction (HER) and Oxygen Evolution Reaction (OER) leads to undesired increased overpotential and constrained reaction kinetics. These challenges pose significant challenges that demand innovative solutions to overcome. One of the efficient ways to address this issue is tailoring the morphology and crystal structure of metal-organic frameworks (MOF)...
November 3, 2023: Chemosphere
https://read.qxmd.com/read/37885403/hyperprogressive-disease-hpd-in-solid-tumours-receiving-immune-checkpoint-inhibitors-in-a-real-world-setting
#30
JOURNAL ARTICLE
Yada Kanjanapan, Geetha Guduguntla, Ashwati Krishnan Varikara, Jeremy Szajer, Desmond Yip, John Cockburn, Mitali Fadia
Introduction: Hyperprogressive disease (HPD) is a state of accelerated tumor growth from cancer immunotherapy, associated with poor outcome. The reported incidence is 6% to 29% among studies using varying definitions of HPD, with no predictive biomarkers. Tumor infiltrating lymphocytes (TILs) are prognostic and predictive for immunotherapy benefit in various tumor types, but have only been tested for correlation with HPD in one study. Objectives: The objective of the study was to determine the prevalence of HPD in solid tumor patients treated with immune checkpoint inhibitor therapy in a real-world setting, and to assess clinicopathological features as potential biomarkers for HPD...
2023: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/37875408/-rational-design-of-high-performance-metal-organic-framework-stationary-phase-for-gas-chromatography
#31
JOURNAL ARTICLE
Han Yang, Wen-Qi Tang, Chu Zeng, Sha-Sha Meng, Ming Xu
Metal organic frameworks (MOFs) are assembled from metal ions or clusters and organic ligands. The high tunability of these components offers a solid structural foundation for achieving efficient gas chromatography (GC) separation. This review demonstrates that the design of high performance MOFs with suitable stationarity should consider both the thermodynamic interactions provided by these MOFs and the kinetic diffusion of analytes. Thermodynamic parameters are basic indicators for describing the interactions between various analytes and the stationary phase...
October 2023: Se Pu, Chinese Journal of Chromatography
https://read.qxmd.com/read/37857527/divergent-tumor-and-immune-cell-reprogramming-underlying-immunotherapy-response-and-immune-related-adverse-events-in-lung-squamous-cell-carcinoma
#32
JOURNAL ARTICLE
Minjiang Chen, Pengfei Ma, Yongchang Zhang, Dong Wang, Zhuang Yu, Yujie Fu, Xiaojing Zhao, Mengzhao Wang, Guanglei Zhuang, Ying Jing
BACKGROUND: Lung squamous cell carcinoma (LUSC) remains a leading cause of cancer-related deaths with few therapeutic strategies. Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy in patients with LUSC. However, ICIs could also lead to a unique spectrum of immune-related adverse events (irAEs), which dampen the clinical outcome. In-depth characterization of the immune hallmarks of antitumor responses and irAEs remains an unmet need to maximize ICI-treatment benefits of patients...
October 2023: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/37829041/hybrid-bronzes-mixed-valence-organic-inorganic-metal-oxides-as-a-tunable-material-platform
#33
JOURNAL ARTICLE
W Lakna N Dayaratne, Raúl Torres-Cadena, Bennett P Schmitt, Emma M Westrick, Adam Jaffe
We demonstrate that mixed-valence layered organic-inorganic metal oxides of the form (L) z H x MO3 (L = neutral ligand; M = Mo, W; z = 0.5, 1; 0 < x < 2), which we call hybrid bronzes , can be readily synthesized through mild solution-state self-assembly reactions to integrate the stability and electronic utility of inorganic metal oxide bronzes with the chemical diversity and functionality of organic molecules. We use single-crystal and powder X-ray diffraction coupled with X-ray, electronic, and vibrational spectroscopies to show that the products of aqueous pre-, mid-, or post-synthetic reduction are mixed-valence versions of highly crystalline layered hybrid oxides...
October 11, 2023: Chemical Science
https://read.qxmd.com/read/37823709/immune-signatures-of-checkpoint-inhibitor-induced-autoimmunity-a-focus-on-neurotoxicity
#34
JOURNAL ARTICLE
Leonie Müller-Jensen, Axel R Schulz, Henrik E Mei, Raphael Mohr, Claas Ulrich, Philipp Knape, Nikolaj Frost, Stefan Frischbutter, Desiree Kunkel, Christian Schinke, Lorena Ginesta Roque, Smilla K Maierhof, Florian T Nickel, Lucie Heinzerling, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen, Samuel Knauss
BACKGROUND: Neurologic immune-related adverse events (irAE-n) are rare but severe toxicities of immune checkpoint inhibitor (ICI) treatment. To overcome diagnostic and therapeutic challenges, a better mechanistic understanding of irAE-n is paramount. METHODS: In this observational cohort study, we collected serum and peripheral blood samples from 34 consecutive cancer patients with irAE-n (during acute illness) and 49 cancer control patients without irAE-n (pre- and on-ICI treatment, n = 44 without high-grade irAEs, n = 5 with high-grade nonneurologic irAEs)...
October 12, 2023: Neuro-oncology
https://read.qxmd.com/read/37795089/pre-organized-landscape-of-t-cell-surface
#35
REVIEW
Yunmin Jung
T cell activation is initiated by the recognition of specific antigenic peptides and subsequently accomplished by complex signaling cascades. These aspects have been extensively studied for decades as pivotal factors in the establishment of adaptive immunity. However, how receptors or signaling molecules are organized in the resting state prior to encountering antigens has received less attention. Recent advancements in super-resolution microscopy techniques have revealed topographically controlled pre-formed organization of key molecules involved in antigen recognition and signal transduction on microvillar projections of T cells before activation and substantial effort has been dedicated to characterizing the topological structure of resting T cells over the past decade...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37727953/laser-interstitial-thermal-therapy-induces-robust-local-immune-response-for-newly-diagnosed-glioblastoma-with-long-term-survival-and-disease-control
#36
JOURNAL ARTICLE
Jay S Chandar, Shovan Bhatia, Shreya Ingle, Mynor J Mendez Valdez, Dragan Maric, Deepa Seetharam, Jelisah F Desgraves, Vaidya Govindarajan, Lekhaj Daggubati, Martin Merenzon, Alexis Morell, Evan Luther, Ali G Saad, Ricardo J Komotar, Michael E Ivan, Ashish H Shah
Laser interstitial thermal therapy (LITT) is a minimally invasive neurosurgical technique used to ablate intra-axial brain tumors. The impact of LITT on the tumor microenvironment is scarcely reported. Nonablative LITT-induced hyperthermia (33-43˚C) increases intra-tumoral mutational burden and neoantigen production, promoting immunogenic cell death. To understand the local immune response post-LITT, we performed longitudinal molecular profiling in a newly diagnosed glioblastoma and conducted a systematic review of anti-tumoral immune responses after LITT...
September 19, 2023: Journal of Immunotherapy
https://read.qxmd.com/read/37722633/mammalian-odorant-binding-proteins-are-prone-to-form-amorphous-aggregates-and-amyloid-fibrils
#37
JOURNAL ARTICLE
Olga V Stepanenko, Anna I Sulatskaya, Maksim I Sulatsky, Ekaterina V Mikhailova, Irina M Kuznetsova, Konstantin K Turoverov, Olesya V Stepanenko
Odorant-binding proteins are involved in perceiving smell by capturing odorants within the protein's β-barrel. On the example of bovine odorant-binding protein (bOBP), the structural organization of such proteins and their ability to bind ligands under various conditions in vitro were examined. We found a tendency of bOBP to form oligomers and small amorphous aggregates without disturbing the integrity of protein monomers at physiological conditions. Changes in environmental parameters (increased temperature and pH) favored the formation of larger and dense supramolecular complexes that significantly reduce the binding of ligands by bOBP...
September 16, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37718900/advances-in-the-administration-of-vitamin-d-analogues-to-support-bone-health-and-treat-chronic-diseases
#38
JOURNAL ARTICLE
Yoshiaki Kanemoto, Miho Iwaki, Takahiro Sawada, Koki Nojiri, Tomohiro Kurokawa, Rino Tsutsumi, Kazuo Nagasawa, Shigeaki Kato
Vitamin D (VD) exerts a wide variety of biological actions in addition to its well-known roles in calcium homeostasis. Nutritional VD deficiency induces rachitic abnormalities in growing children and osteomalacia in adults, and it has been proposed to underlie the onset and development of multiple non-communicable chronic diseases. Therefore, the administration of VD or synthetic VD analogues represents a promising therapeutic strategy; indeed, VD and a VD agonist have shown clinical promise in mitigating osteoporosis and symptoms of insufficient calcium intake...
August 2023: Journal of Bone Metabolism
https://read.qxmd.com/read/37705751/apelin-prevents-and-alleviates-crystalline-silica-induced-pulmonary-fibrosis-via-inhibiting-transforming-growth-factor-beta-1-triggered-fibroblast-activation
#39
JOURNAL ARTICLE
Jianling Shen, Jiayin Feng, Zhijia Wu, Yushi Ou, Qing Zhang, Qiying Nong, Qifeng Wu, Cong Li, Xiaohui Tan, Meng Ye, Zhongxiang Gao, Ying Zhang, Weihui Liang, Lihua Xia, Yiru Qin, Yongshun Huang, Na Zhao, Shijie Hu
Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein-coupled receptor (APJ), is abundantly expressed in diverse organs. The apelin-APJ axis helps to control pathological and physiological processes in lung. The role of apelin in the pathological process and its possible therapeutic effects on silicosis have not been elucidated. In this study, we found that lung expression and circulating levels of apelin were markedly decreased in silicosis patients and silica-induced fibrotic mice and associated with the severity...
2023: International Journal of Biological Sciences
https://read.qxmd.com/read/37698425/descriptor-driven-de-novo-design-algorithms-for-dock6-using-rdkit
#40
JOURNAL ARTICLE
Guilherme Duarte Ramos Matos, Steven Pak, Robert C Rizzo
Structure-based methods that employ principles of de novo design can be used to construct small organic molecules from scratch using pre-existing fragment libraries to sample chemical space and are an important class of computational algorithms for drug-lead discovery. Here, we present a powerful new design method for DOCK6 that employs a Descriptor-Driven De Novo strategy (termed D3N) in which user-defined cheminformatics descriptors (and their target ranges) are calculated at each layer of growth using the open-source toolkit RDKit...
September 12, 2023: Journal of Chemical Information and Modeling
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