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Pre-organized ligand

Younghoon Kim, Jaehyoung Koo, In-Chul Hwang, Rahul Dev Mukhopadhyay, Soonsang Hong, Jejoong Yoo, Ajaz Ahmad Dar, Ikjin Kim, Dohyun Moon, Tae Joo Shin, Young Ho Ko, Kimoon Kim
We report a new approach to building hierarchical superstructures using a shape-persistent porous organic cage, which acts as a premade secondary building unit, and coordination chemistry. To illustrate the principle, a zinc-metalated porphyrin box (Zn-PB), a corner-truncated cubic porous cage, was connected by suitable dipyridyl terminated bridging ligands to construct PB-based hierarchical superstructures (PSSs). The PSSs were stabilized not only by the coordination bonds between Zn ions and bipyridyl-terminated ligands but also by π-π interactions between the corners of the Zn-PB units...
October 3, 2018: Journal of the American Chemical Society
Walhan Alshaer, Hervé Hillaireau, Elias Fattal
Aptamers are versatile nucleic acid-based macromolecules characterized by their high affinity and specificity to a specific target. Taking advantage of such binding properties, several aptamers have been selected to bind tumor biomarkers and have been used as targeting ligands for the functionalization of nanomedicines. Different functionalization methods have been used to link aptamers to the surface drug nanocarriers. The pre-clinical data of such nanomedicines overall show an enhanced and selective delivery of therapeutic payloads to cancer cells, thereby accelerating steps towards more effective therapeutic systems...
September 26, 2018: Advanced Drug Delivery Reviews
Andrew Oliphant, Jodi L Alexander, Martin T Swain, Simon G Webster, David C Wilcockson
BACKGROUND: Ecdysis is an innate behaviour programme by which all arthropods moult their exoskeletons. The complex suite of interacting neuropeptides that orchestrate ecdysis is well studied in insects, but details of the crustacean ecdysis cassette are fragmented and our understanding of this process is comparatively crude, preventing a meaningful evolutionary comparison. To begin to address this issue we identified transcripts coding for neuropeptides and their putative receptors in the central nervous system (CNS) and Y-organs (YO) within the crab, Carcinus maenas, and mapped their expression profiles across accurately defined stages of the moult cycle using RNA-sequencing...
September 26, 2018: BMC Genomics
Kerstin B Ksionzek, Jing Zhang, Kai-Uwe Ludwichowski, Dorothee Wilhelms-Dick, Scarlett Trimborn, Thomas Jendrossek, Gerhard Kattner, Boris P Koch
Dissolved organic matter (DOM) is ubiquitous in natural waters and plays a central role in the biogeochemistry in riverine, estuarine and marine environments. This study quantifies and characterizes solid-phase extractable DOM and trace element complexation at different salinities in the Weser and Elbe River, northern Germany, and the North Sea. Dissolved organic carbon (DOC), total dissolved nitrogen (TDN), Co and Cu concentrations were analyzed in original water samples. Solid-phase extracted (SPE) water samples were analyzed for DOC (DOCSPE), dissolved organic nitrogen (DONSPE), sulfur (DOSSPE) and trace metal (51V, 52Cr, 59Co, 60Ni, 63Cu, 75As) concentrations...
2018: PloS One
Pradeep Manuneedhi Cholan, Siân P Cartland, Lei Dang, Benjamin S Rayner, Sanjay Patel, Shane R Thomas, Mary M Kavurma
The vascular endothelium is critical for maintenance of cardiovascular homeostasis. Endothelial dysfunction is a key event of atherosclerosis, with oxidative stress mediated by reactive oxygen species (ROS) playing a major role. Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is increasingly recognised to play a protective role in atherosclerosis, however the molecular mechanisms by which it exerts its beneficial effects are unclear. Here we examined if TRAIL could attenuate vascular oxidative stress and improve endothelial cell (EC) function...
October 2018: Free Radical Biology & Medicine
Halis Kaan Akturk, Aimon Alkanani, Zhiyuan Zhao, Liping Yu, Aaron W Michels
Context: Immune checkpoint inhibitors, including monoclonal antibodies directed against programmed cell death protein 1 (PD-1) and its ligand, have emerged as beneficial cancer immunotherapies. These therapies are known to cause immune-related side effects; however, their role in patients with a preexisting autoimmune disease is not clear. Case Description: We describe two cases of anti-PD-1 immune-related adverse events. A 52-year-old male with longstanding type 1 diabetes (T1D), long-term stable kidney transplant, and hypothyroidism received two separate anti-PD-1 monoclonal antibodies for metastatic melanoma...
October 1, 2018: Journal of Clinical Endocrinology and Metabolism
Zhongwei Liu, Yuan Wang, Haitao Zhu, Chuan Qiu, Gongchang Guan, Junkui Wang, Yan Guo
Vascular smooth muscle cells (VSMCs) contractile- synthetic phenotypic conversion takes responsibility in the atherosclerotic plaque formation by abnormal synthesis, secretion and deposition of extracellular matrix (ECM). Matrine exerts therapeutic effects on both cardiovascular diseases and organ fibrosis. In this study, we investigated matrine's inhibitory effect and mechanisms on AGEs- induced VSMC contractile- synthetic phenotypic conversion. Cultured human coronary smooth muscle cells (HCSMCs) were exposed to AGEs...
September 15, 2018: European Journal of Pharmacology
Zhenbo Mo, Arseni Kostenko, Yu-Peng Zhou, Shenglai Yao, Matthias Driess
The first N-heterocyclic silylene (NHSi)-silane scaffold LSi-R-Si(H)Mes2 (1) (L=PhC(NtBu)2 ; R=1,12-xanthendiyl spacer; Mes=2,4,6-Me3 C6 H2 ) was synthesized and used to form the unique rhodium(III) complex (LSi-R-SiMes2 )Rh(H)Cl 2 through its reaction with 0.5 molar equivalents of [Rh(coe)2 Cl]2 (coe=cyclooctene). An X-ray diffraction analysis revealed that 2 has a (SiII SiIV )Rh(H)Cl core with three short Rh⋅⋅⋅H-C contacts with Me groups of the ligand 1, which cause a distorted pentagonal bipyramidal coordination of the Rh center...
October 1, 2018: Chemistry: a European Journal
Jenny Halleröd, Chrisitan Ekberg, Ivan Kajan, Emma Aneheim
The two organic ligands 6,6'-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrobenzo[1,2,4]triazin-3-yl)[2,2']bipyridine (CyMe <mml:math xmlns:mml=""> <mml:msub> <mml:mrow/> <mml:mn>4</mml:mn> </mml:msub> </mml:math> -BTBP) and tri-butyl phosphate (TBP) have previously been investigated in different diluents for use within recycling of used nuclear fuel through solvent extraction. The thermodynamic parameters, <mml:math xmlns:mml="http://www...
2018: Journal of Solution Chemistry
Asaf A Qureshi, Dilshad A Khan, Shahida Mushtaq, Shui Qing Ye, Min Xiong, Nilofer Qureshi
BACKGROUND: δ-Tocotrienol is a naturally occurring proteasome inhibitor, which has the capacity to inhibit proliferation and induce apoptosis in several cancer cells obtained from several organs of humans, and other cancer cell lines. Moreover, results of plasma total mRNAs after δ-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-α, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-γ after post-treatment...
July 21, 2018: Lipids in Health and Disease
Hao Li, Jinghua Wang, Boyi Zhao, Manshu Gao, Wenjing Shi, Haijun Zhou, Zhilei Xie, Bin Zhou, Changwei Lü, Jiang He
Fulvic acid (FA) plays a key role in governing the environmental geochemistry behavior of heavy metals. In this work, the roles of major functional groups were investigated based on binding experiments of heavy metals on natural FA extracted from lake sediments. The results showed that the adsorption capacities were ranked as Cu2+ > Pb2+ >Cd2+ . The differences of peak area at 3412, 1713, 617and 2430 cm-1 pre- and post-binding reactions in FTIR spectra suggested that phenolic, carboxyl and nitrogen-containing groups were the major functional groups providing sites binding heavy metals...
October 30, 2018: Ecotoxicology and Environmental Safety
Mani Ghanipoor-Samami, Ali Javadmanesh, Brian M Burns, Dana A Thomsen, Greg S Nattrass, Consuelo Amor S Estrella, Karen L Kind, Stefan Hiendleder
The insulin-like growth factor (IGF) axis is fundamental for mammalian growth and development. However, no comprehensive reference data on gene expression across tissues and pre- and postnatal developmental stages are available for any given species. Here we provide systematic promoter- and splice variant specific information on expression of IGF system components in embryonic (Day 48), fetal (Day 153), term (Day 277, placenta) and juvenile (Day 365-396) tissues of domestic cow, a major agricultural species and biomedical model...
2018: PloS One
Sophie M Morgani, Nestor Saiz, Vidur Garg, Dhruv Raina, Claire S Simon, Minjung Kang, Alfonso Martinez Arias, Jennifer Nichols, Christian Schröter, Anna-Katerina Hadjantonakis
The FGF/ERK signaling pathway is highly conserved throughout evolution and plays fundamental roles during embryonic development and in adult organisms. While a plethora of expression data exists for ligands, receptors and pathway regulators, we know little about the spatial organization or dynamics of signaling in individual cells within populations. To this end we developed a transcriptional readout of FGF/ERK activity by targeting a histone H2B-linked Venus fluorophore to the endogenous locus of Spry4, an early pathway target, and generated Spry4H2B-Venus embryonic stem cells (ESCs) and a derivative mouse line...
September 1, 2018: Developmental Biology
Jing Wei, Gen Wang, Feng Chen, Min Bai, Yan Liang, Huanting Wang, Dongyuan Zhao, Yongxi Zhao
A formaldehyde-assisted metal-ligand crosslinking strategy is used for the synthesis of metal-phenolic coordination spheres based on sol-gel chemistry. A range of mono-metal (Co, Fe, Al, Ni, Cu, Zn, Ce), bi-metal (Fe-Co, Co-Zn) and multi-metal (Fe-Co-Ni-Cu-Zn) species can be incorporated into the frameworks of the colloidal spheres. The formation of coordination spheres involves the pre-crosslinking of plant polyphenol (such as tannic acid) by formaldehyde in alkaline ethanol/water solvents, followed by the aggregation assembly of polyphenol oligomers via metal-ligand crosslinking...
July 26, 2018: Angewandte Chemie
Stuart J Cook, Quintin Lee, Alex Ch Wong, Benjamin C Spann, Jonathan N Vincent, Justin Jl Wong, Andreas Schlitzer, Mark D Gorrell, Wolfgang Weninger, Ben Roediger
Conventional dendritic cells (cDCs) are continuously replenished by bone marrow-derived precursors called pre-DCs, which traffic through the blood to peripheral tissues. Pre-DCs are a heterogeneous population that includes cDC subset-committed progenitors, namely pre-cDC1 and pre-cDC2, which give rise to mature cDC1 and cDC2, respectively. Regulation of pre-DC subset trafficking is thought to aid the host response to immune challenge. However, the molecular cues regulating pre-cDC1 versus pre-cDC2 trafficking toward peripheral sites during homeostasis and disease remain elusive...
June 19, 2018: Immunology and Cell Biology
Anton A Ivanov, Clément Falaise, Pavel A Abramov, Michael A Shestopalov, Kaplan Kirakci, Kamil Lang, Mhamad A Moussawi, Maxim N Sokolov, Nikolay G Naumov, Sébastien Floquet, David Landy, Mohamed Haouas, Konstantin A Brylev, Yuri V Mironov, Yann Molard, Stéphane Cordier, Emmanuel Cadot
Water-soluble salts of anionic [Re6 Q8 (CN)6 ]4- (Q=S, Se, Te) chalcogenide octahedral rhenium clusters react with γ-cyclodextrin (γ-CD) producing a new type of inclusion compounds. Crystal structures determined through single-crystal X-ray diffraction analysis revealed supramolecular host-guest assemblies resulting from close encapsulations of the octahedral cluster within two γ-CDs. Interestingly, nature of the inner Q ligands influences strongly the host-guest conformation. The cluster [Re6 S8 (CN)6 ]4- interacts preferentially with the primary faces of the γ-CD while the bulkier clusters [Re6 Se8 (CN)6 ]4- and [Re6 Te8 (CN)6 ]4- exhibit specific interactions with the secondary faces of the cyclic host...
September 12, 2018: Chemistry: a European Journal
Lei-Lei Liu, You-Zhu Yu, Xue-Jing Zhao, Ya-Ru Wang, Fei-Yang Cheng, Meng-Ke Zhang, Jing-Jing Shu, Lin Liu
Based on the inner filter effect, a luminescent Zn(ii)/Na(i) metal-organic framework (MOF) {[Zn2Na(L)(HL)2(H2O)2][OAc]·2H2O}n (1, H2L = 5-methyl-1,3-benzenedicarboxylic acid) with excellent stability was constructed for the fluorescence detection of Cu2+ ions. MOF 1 holds a 3D cationic framework in which [(OAc)2(H2O)2]n2n- anions are embedded into its 1D channels. Abundant hydrogen-bonding and π-π interactions in the MOF facilitate electron transfer from ligand-to-metal, resulting in a good luminescence peak at 412 nm and an efficient fluorescence quenching of MOF 1 in the presence of Cu2+ ions, due to the inner filter effect...
June 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Christian Mair, Boris Warwitz, Katharina Fink, Lorenza Scarpa, Bernhard Nilica, Johanna Maffey-Steffan, Sabine Buxbaum, Irene J Virgolini
PURPOSE: As radionuclide therapy is gaining importance in palliative treatment of patients suffering from neuroendocrine tumour (NET) as well as castration resistant prostate cancer (CRPC), the radiation protection of patients, staff, family members and the general public is of increasing interest. Here, we determine patient discharge dates according to European guidelines. METHODS: In 40 patients with NET and 25 patients with CRPC organ and tumour doses based on the MIRD concept were calculated from data obtained during the first therapy cycle...
August 2018: Annals of Nuclear Medicine
Lorien Benda, Benjamin Doistau, Bernold Hasenknopf, Guillaume Vives
Molecular tweezers are artificial receptors that have an open cavity generated by two recognition units pre-organized by a spacer. Switchable molecular tweezers, using a stimuli-responsive spacer, are particularly appealing as prototypes of the molecular machines that combine mechanical motion and allosteric recognition properties. In this present study, the synthesis of switchable molecular tweezers composed of a central terpyridine unit substituted in 4,4&Prime; positions by two Pt(II)-salphen complexes is reported...
April 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Cristina Vergel, Carolina Mendiguchía, Carlos Moreno
The different species of nickel present in natural waters exhibit different transport behaviour through bulk liquid membranes (BLMs). This fact has been used to design and optimise a separation/pre-concentration system applicable to separate labile and non-labile nickel fractions. A hydrazone derivative-1,2-cyclohexanedione bis-benzoyl-hydrazone (1,2-CHBBH) dissolved in toluene/dimethyl formamide (2% DMF)-was used as a chemical carrier of nickel species, from an aqueous source solution (sample) to a receiving acidic solution...
April 15, 2018: Membranes
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