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https://www.readbyqxmd.com/read/30063915/matrine-blocks-ages-induced-hcsmcs-phenotypic-conversion-via-suppressing-dll4-notch-pathway
#1
Zhongwei Liu, Yuan Wang, Haitao Zhu, Chuan Qiu, Gongchang Guan, Junkui Wang, Yan Guo
Vascular smooth muscle cells (VSMCs) contractile- synthetic phenotypic conversion takes responsibility in the atherosclerotic plaque formation by abnormal synthesis, secretion and deposition of extracellular matrix (ECM). Matrine exerts therapeutic effects on both cardiovascular diseases and organ fibrosis. In this study, we investigated matrine's inhibitory effect and mechanisms on AGEs- induced VSMC contractile- synthetic phenotypic conversion. Cultured human coronary smooth muscle cells (HCSMCs) were exposed to AGEs...
July 29, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30055025/a-chelate-silylene-silyl-ligand-can-boost-rhodium-catalyzed-c-h-bond-functionalizations
#2
Matthias Driess, Zhenbo Mo, Arseni Kostenko, Yupeng Zhou, Shenglai Yao
The first N-heterocyclic silylene (NHSi)-silane scaffold LSi-R-Si(H)Mes2 1 (L = PhC(NtBu)2; -R- = 1,12-xanthendiyl spacer; Mes = 2,4,6-Me3C6H2) was synthesized and used to form the unique rhodium(III) complex (LSi-R-SiMes2)Rh(H)Cl 2 through its reaction with 0.5 molar equivalents of [Rh(coe)2Cl]2 (coe = cyclooctene). An X-ray diffraction analysis revealed that 2 has a (SiIISiIV)Rh(H)Cl core with three short Rh···H-C contacts with Me groups of the ligand 1, which cause a distorted pentagonal-bipyramidal coordination of the Rh center...
July 28, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30046200/solubility-thermodynamics-of-cyme-4-btbp-in-various-diluents-mixed-with-tbp
#3
Jenny Halleröd, Chrisitan Ekberg, Ivan Kajan, Emma Aneheim
The two organic ligands 6,6'-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrobenzo[1,2,4]triazin-3-yl)[2,2']bipyridine (CyMe <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mrow/> <mml:mn>4</mml:mn> </mml:msub> </mml:math> -BTBP) and tri-butyl phosphate (TBP) have previously been investigated in different diluents for use within recycling of used nuclear fuel through solvent extraction. The thermodynamic parameters, <mml:math xmlns:mml="http://www...
2018: Journal of Solution Chemistry
https://www.readbyqxmd.com/read/30031388/%C3%AE-tocotrienol-feeding-modulates-gene-expression-of-eif2-mtor-protein-ubiquitination-through-multiple-signaling-pathways-in-chronic-hepatitis-c-patients
#4
Asaf A Qureshi, Dilshad A Khan, Shahida Mushtaq, Shui Qing Ye, Min Xiong, Nilofer Qureshi
BACKGROUND: δ-Tocotrienol is a naturally occurring proteasome inhibitor, which has the capacity to inhibit proliferation and induce apoptosis in several cancer cells obtained from several organs of humans, and other cancer cell lines. Moreover, results of plasma total mRNAs after δ-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-α, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-γ after post-treatment...
July 21, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30015198/the-role-of-major-functional-groups-multi-evidence-from-the-binding-experiments-of-heavy-metals-on-natural-fulvic-acids-extracted-from-lake-sediments
#5
Hao Li, Jinghua Wang, Boyi Zhao, Manshu Gao, Wenjing Shi, Haijun Zhou, Zhilei Xie, Bin Zhou, Changwei Lü, Jiang He
Fulvic acid (FA) plays a key role in governing the environmental geochemistry behavior of heavy metals. In this work, the roles of major functional groups were investigated based on binding experiments of heavy metals on natural FA extracted from lake sediments. The results showed that the adsorption capacities were ranked as Cu2+ > Pb2+ >Cd2+ . The differences of peak area at 3412, 1713, 617and 2430 cm-1 pre- and post-binding reactions in FTIR spectra suggested that phenolic, carboxyl and nitrogen-containing groups were the major functional groups providing sites binding heavy metals...
October 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30001361/atlas-of-tissue-and-developmental-stage-specific-gene-expression-for-the-bovine-insulin-like-growth-factor-igf-system
#6
Mani Ghanipoor-Samami, Ali Javadmanesh, Brian M Burns, Dana A Thomsen, Greg S Nattrass, Consuelo Amor S Estrella, Karen L Kind, Stefan Hiendleder
The insulin-like growth factor (IGF) axis is fundamental for mammalian growth and development. However, no comprehensive reference data on gene expression across tissues and pre- and postnatal developmental stages are available for any given species. Here we provide systematic promoter- and splice variant specific information on expression of IGF system components in embryonic (Day 48), fetal (Day 153), term (Day 277, placenta) and juvenile (Day 365-396) tissues of domestic cow, a major agricultural species and biomedical model...
2018: PloS One
https://www.readbyqxmd.com/read/29964027/a-sprouty4-reporter-to-monitor-fgf-erk-signaling-activity-in-escs-and-mice
#7
Sophie M Morgani, Nestor Saiz, Vidur Garg, Dhruv Raina, Claire S Simon, Minjung Kang, Alfonso Martinez Arias, Jennifer Nichols, Christian Schröter, Anna-Katerina Hadjantonakis
The FGF/ERK signaling pathway is highly conserved throughout evolution and plays fundamental roles during embryonic development and in adult organisms. While a plethora of expression data exists for ligands, receptors and pathway regulators, we know little about the spatial organization or dynamics of signaling in individual cells within populations. To this end we developed a transcriptional readout of FGF/ERK activity by targeting a histone H2B-linked Venus fluorophore to the endogenous locus of Spry4, an early pathway target, and generated Spry4H2B-Venus embryonic stem cells (ESCs) and a derivative mouse line...
September 1, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29927033/sol-gel-synthesis-of-metal-phenolic-coordination-spheres-and-their-derived-carbon-composites
#8
Jing Wei, Gen Wang, Feng Chen, Min Bai, Yan Liang, Huanting Wang, Dongyuan Zhao, Yongxi Zhao
A formaldehyde-assisted metal-ligand crosslinking strategy is used for the synthesis of metal-phenolic coordination spheres based on sol-gel chemistry. A range of mono-metal (Co, Fe, Al, Ni, Cu, Zn, Ce), bi-metal (Fe-Co, Co-Zn) and multi-metal (Fe-Co-Ni-Cu-Zn) species can be incorporated into the frameworks of the colloidal spheres. The formation of coordination spheres involves the pre-crosslinking of plant polyphenol (such as tannic acid) by formaldehyde in alkaline ethanol/water solvents, followed by the aggregation assembly of polyphenol oligomers via metal-ligand crosslinking...
June 21, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29920767/differential-chemokine-receptor-expression-and-usage-by-pre-cdc1-and-pre-cdc2
#9
Stuart J Cook, Quintin Lee, Alex Ch Wong, Benjamin C Spann, Jonathan N Vincent, Justin Jl Wong, Andreas Schlitzer, Mark D Gorrell, Wolfgang Weninger, Ben Roediger
Conventional dendritic cells (cDCs) are continuously replenished by bone marrow-derived precursors called pre-DCs, which traffic through the blood to peripheral tissues. Pre-DCs are a heterogeneous population that includes cDC subset-committed progenitors, namely pre-cDC1 and pre-cDC2, which give rise to mature cDC1 and cDC2, respectively. Regulation of pre-DC subset trafficking is thought to aid the host response to immune challenge. However, the molecular cues regulating pre-cDC1 versus pre-cDC2 trafficking toward peripheral sites during homeostasis and disease remain elusive...
June 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29894019/host-guest-binding-hierarchy-within-redox-and-luminescence-responsive-supramolecular-self-assembly-based-on-chalcogenide-clusters-and-%C3%AE-cyclodextrin
#10
Anton A Ivanov, Clément Falaise, Pavel A Abramov, Michael A Shestopalov, Kaplan Kirakci, Kamil Lang, Mhamad A Moussawi, Maxim N Sokolov, Nikolay G Naumov, Sébastien Floquet, David Landy, Mohamed Haouas, Konstantin A Brylev, Yuri V Mironov, Yann Molard, Stéphane Cordier, Emmanuel Cadot
Water-soluble salts of anionic [Re6 Q8 (CN)6 ]4- (Q=S, Se, Te) chalcogenide octahedral rhenium clusters react with γ-cyclodextrin (γ-CD) producing a new type of inclusion compounds. Crystal structures determined through single-crystal X-ray diffraction analysis revealed supramolecular host-guest assemblies resulting from close encapsulations of the octahedral cluster within two γ-CDs. Interestingly, nature of the inner Q ligands influences strongly the host-guest conformation. The cluster [Re6 S8 (CN)6 ]4- interacts preferentially with the primary faces of the γ-CD while the bulkier clusters [Re6 Se8 (CN)6 ]4- and [Re6 Te8 (CN)6 ]4- exhibit specific interactions with the secondary faces of the cyclic host...
June 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29845997/a-robust-zn-ii-na-i-mof-decorated-with-oac-2-h-2-o-2-n-2n-anions-for-the-luminescence-sensing-of-copper-ions-based-on-the-inner-filter-effect
#11
Lei-Lei Liu, You-Zhu Yu, Xue-Jing Zhao, Ya-Ru Wang, Fei-Yang Cheng, Meng-Ke Zhang, Jing-Jing Shu, Lin Liu
Based on the inner filter effect, a luminescent Zn(ii)/Na(i) metal-organic framework (MOF) {[Zn2Na(L)(HL)2(H2O)2][OAc]·2H2O}n (1, H2L = 5-methyl-1,3-benzenedicarboxylic acid) with excellent stability was constructed for the fluorescence detection of Cu2+ ions. MOF 1 holds a 3D cationic framework in which [(OAc)2(H2O)2]n2n- anions are embedded into its 1D channels. Abundant hydrogen-bonding and π-π interactions in the MOF facilitate electron transfer from ligand-to-metal, resulting in a good luminescence peak at 412 nm and an efficient fluorescence quenching of MOF 1 in the presence of Cu2+ ions, due to the inner filter effect...
June 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29797003/radiation-exposure-after-177-lu-dotatate-and-177-lu-psma-617-therapy
#12
Christian Mair, Boris Warwitz, Katharina Fink, Lorenza Scarpa, Bernhard Nilica, Johanna Maffey-Steffan, Sabine Buxbaum, Irene J Virgolini
PURPOSE: As radionuclide therapy is gaining importance in palliative treatment of patients suffering from neuroendocrine tumour (NET) as well as castration resistant prostate cancer (CRPC), the radiation protection of patients, staff, family members and the general public is of increasing interest. Here, we determine patient discharge dates according to European guidelines. METHODS: In 40 patients with NET and 25 patients with CRPC organ and tumour doses based on the MIRD concept were calculated from data obtained during the first therapy cycle...
August 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29695059/synthesis-and-guest-recognition-of-switchable-pt-salphen-based-molecular-tweezers
#13
Lorien Benda, Benjamin Doistau, Bernold Hasenknopf, Guillaume Vives
Molecular tweezers are artificial receptors that have an open cavity generated by two recognition units pre-organized by a spacer. Switchable molecular tweezers, using a stimuli-responsive spacer, are particularly appealing as prototypes of the molecular machines that combine mechanical motion and allosteric recognition properties. In this present study, the synthesis of switchable molecular tweezers composed of a central terpyridine unit substituted in 4,4&Prime; positions by two Pt(II)-salphen complexes is reported...
April 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29662040/liquid-membranes-as-a-tool-for-chemical-speciation-of-metals-in-natural-waters-organic-and-inorganic-complexes-of-nickel
#14
Cristina Vergel, Carolina Mendiguchía, Carlos Moreno
The different species of nickel present in natural waters exhibit different transport behaviour through bulk liquid membranes (BLMs). This fact has been used to design and optimise a separation/pre-concentration system applicable to separate labile and non-labile nickel fractions. A hydrazone derivative-1,2-cyclohexanedione bis-benzoyl-hydrazone (1,2-CHBBH) dissolved in toluene/dimethyl formamide (2% DMF)-was used as a chemical carrier of nickel species, from an aqueous source solution (sample) to a receiving acidic solution...
April 15, 2018: Membranes
https://www.readbyqxmd.com/read/29556192/leadop-r-structure-based-lead-optimization-with-synthetic-accessibility
#15
Fang-Yu Lin, Emilio Xavier Esposito, Yufeng J Tseng
We previously described a structure-based fragment hopping for lead optimization using a pre-docked fragment database, "LeadOp," that conceptually replaced "bad" fragments of a ligand with "good" fragments while leaving the core of the ligand intact thus improving the compound's activity. LeadOp was proven to optimize the query molecules and systematically developed improved analogs for each of our example systems. However, even with the fragment-based design from common building blocks, it is still a challenge for synthesis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29488933/solid-energy-calibration-standards-for-p-k-edge-xanes-electronic-structure-analysis-of-pph-4-br
#16
Anastasia V Blake, Haochuan Wei, Courtney M Donahue, Kyounghoon Lee, Jason M Keith, Scott R Daly
P K-edge X-ray absorption near-edge structure (XANES) spectroscopy is a powerful method for analyzing the electronic structure of organic and inorganic phosphorus compounds. Like all XANES experiments, P K-edge XANES requires well defined and readily accessible calibration standards for energy referencing so that spectra collected at different beamlines or under different conditions can be compared. This is especially true for ligand K-edge X-ray absorption spectroscopy, which has well established energy calibration standards for Cl (Cs2 CuCl4 ) and S (Na2 S2 O3 ·5H2 O), but not neighboring P...
March 1, 2018: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/29454987/nature-differences-of-humic-acids-fractions-induced-by-extracted-sequence-as-explanatory-factors-for-binding-characteristics-of-heavy-metals
#17
Wenjing Shi, Changwei Lü, Jiang He, He En, Manshu Gao, Boyi Zhao, Bin Zhou, Haijun Zhou, Hualin Liu, Yu Zhang
The composition and structure of Humic acid (HA) is so heterogeneous that it brings significant barriers to investigate the interaction between HA and heavy metal ions. The isolation of HA with relatively homogeneity is a key to reveal the binding mechanisms between HA and heavy metals. In this work, ten HA fractions (HAs) were obtained by sequential alkali extraction procedure and nature differences of the extracted HAs were considered as explanatory factors for binding characteristics of Cu2+ , Pb2+ and Cd2+ ...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454158/polyisocyanopeptide-hydrogels-a-novel-thermo-responsive-hydrogel-supporting-pre-vascularization-and-the-development-of-organotypic-structures
#18
Jakub Zimoch, Joan Simó Padial, Agnes S Klar, Queralt Vallmajo-Martin, Martin Meuli, Thomas Biedermann, Christopher J Wilson, Alan Rowan, Ernst Reichmann
Molecular and mechanical interactions with the 3D extracellular matrix are essential for cell functions such as survival, proliferation, migration, and differentiation. Thermo-responsive biomimetic polyisocyanopeptide (PIC) hydrogels are promising new candidates for 3D cell, tissue, and organ cultures. This is a synthetic, thermo-responsive and stress-stiffening material synthesized via polymerization of the corresponding monomers using a nickel perchlorate as a catalyst. It can be tailored to meet various demands of cells by modulating its stiffness and through the decoration of the polymer with short GRGDS peptides using copper free click chemistry...
April 1, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29445796/synthesis-and-characterization-of-an-iron-complex-bearing-a-hemilabile-nnn-pincer-for-catalytic-hydrosilylation-of-organic-carbonyl-compounds
#19
Hsiu-Jung Lin, Sean Lutz, Catherine O'Kane, Matthias Zeller, Chun-Hsing Chen, Talal Al Assil, Wei-Tsung Lee
A low-coordinate iron(ii) complex (CztBu (PztBu )2 )Fe[N(SiMe3 )2 ], 1 bearing an NNN-pincer ligand was prepared and fully characterized. Intramolecular C-H activation on the 5-position of a pyrazole at elevated temperatures was observed. Complex 1 was found to be an efficient and chemoselective pre-catalyst for the hydrosilylation of organo carbonyl substrates.
March 6, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29427452/cxcr4-cxcl12-interaction-is-important-for-plasma-cell-homing-and-survival-in-nzb-w-mice
#20
Qingyu Cheng, Laleh Khodadadi, Adriano Taddeo, Jens Klotsche, Bimba F Hoyer, Andreas Radbruch, Falk Hiepe
Antibody-secreting cells (ASCs), including short-lived plasmablasts and long-lived memory plasma cells (LLPCs), contribute to autoimmune pathology. ASCs, particularly LLPCs, refractory to conventional immunosuppressive drugs pose a major therapeutic challenge. Since stromal cells expressing C-X-C motif chemokine-12 (CXCL12) organize survival niches for LLPCs in the bone marrow, we investigated the effects of CXCL12 and its ligand CXCR4 (C-X-C chemokine receptor 4) on ASCs in lupus mice (NZB/W). Fewer adoptively transferred splenic ASCs were retrieved from the bone marrow of recipient immunodeficient Rag1-/- mice when the ASCs were pretreated with the CXCR4 blocker AMD3100...
June 2018: European Journal of Immunology
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