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https://www.readbyqxmd.com/read/30316080/a-new-drug-carrier-with-oxygen-generation-function-for-modulating-tumor-hypoxia-microenvironment-in-cancer-chemotherapy
#1
Zhe Zhang, Na Niu, Xi Gao, Fuqin Han, Zhijun Chen, Shujun Li, Jian Li
Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrier (named as FeSiAuO) containing Fe3 O4 , mesoporous SiO2 and Au2 O3 with magnetic, large surface ratio and light induced oxygen production properties...
October 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30275968/clinical-development-of-photodynamic-agents-and-therapeutic-applications
#2
REVIEW
Rengarajan Baskaran, Junghan Lee, Su-Geun Yang
Background: Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases. Introduction: In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/30268053/novel-assay-for-the-toxicity-evaluation-of-nanoscale-zero-valent-iron-and-derived-nanomaterials-based-on-lipid-peroxidation-in-bacterial-species
#3
Jaroslav Semerád, Monika Čvančarová, Jan Filip, Josef Kašlík, Jana Zlotá, Jana Soukupová, Tomáš Cajthaml
Nano-scale zero-valent iron (nZVI) began attracting research attention in remediation practice in recent decades as a prospective nanomaterial applicable to various contaminated matrices. Despite concerns about the negative effects of nanomaterials on ecosystems, the number of reliable toxicity tests is limited. We have developed a test based on the evaluation of oxidative stress (OS). The test employed the analysis of a typical OS marker (malondialdehyde, MDA), after exposure of six bacterial strains to the tested nanomaterial...
September 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/30252434/relationships-between-crystal-internal-microstructures-and-physicochemical-properties-of-copper-zinc-iron-multinary-spinel-hierarchical-nano-microspheres
#4
Shiying Fan, Xinyong Li, Libin Zeng, Mingmei Zhang, Zhifan Yin, Tingting Lian, Aicheng Chen
Rational design and fabrication of high quality complex multicomponent spinel ferrite with specific microstructures and solar light harvestings towards CO2 reduction and antibiotic degradation to future energetic and catalytic applications are highly desirable. In this study, novel Copper-Zinc-Iron multinary spinel hierarchical nano-microspheres (MSHMs) with different internal structures (solid nano-microspheres, yolk-shell hollow nano-microspheres, and double-shelled hollow nano-microspheres) have been successfully developed by a facile self-templated solvothermal strategy...
September 25, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30247915/peroxidase-mimicking-nanoassembly-mitigates-lipopolysaccharide-induced-endotoxemia-and-cognitive-damage-in-the-brain-by-impeding-inflammatory-signaling-in-macrophages
#5
Santhosh Kalash Rajendrakumar, Vishnu Revuri, Manikandan Samidurai, Adityanarayan Mohapatra, Jae Hyuk Lee, Palanivel Ganesan, Jihoon Jo, Yong-Kyu Lee, In-Kyu Park
Oxidative stress during sepsis pathogenesis remains the most-important factor creating imbalance and dysregulation in immune-cell function, usually observed following initial infection. Hydrogen peroxide (H2 O2 ), a potentially toxic reactive oxygen species (ROS), is excessively produced by pro-inflammatory immune cells during the initial phases of sepsis and plays a dominant role in regulating the pathways associated with systemic inflammatory immune activation. In the present study, we constructed a peroxide scavenger mannosylated polymeric albumin manganese dioxide (mSPAM) nanoassembly to catalyze the decomposition of H2 O2 responsible for the hyper-activation of pro-inflammatory immune cells...
September 27, 2018: Nano Letters
https://www.readbyqxmd.com/read/30246020/modulation-of-diabetes-mellitus-induced-male-rat-reproductive-dysfunction-with-micro-nanoencapsulated-echinacea-purpurea-ethanol-extract
#6
Chien-Feng Mao, Xiu-Ru Zhang, Athira Johnson, Jia-Ling He, Zwe-Ling Kong
Diabetes mellitus is a major health problem that affects a patient's life quality throughout the world due to its worst complications. It was recognized that chronic hyperglycemia with oxidative stress was the major cause of male infertility. Echinacea purpurea ethanol extract (EE) contains phenolic acid and isobutylamides had been proven to ameliorate diabetic complications. Chitosan/silica nanoparticles are well-known in the medicinal field because of its controlled release and drug delivery properties. This study was aimed at investigating whether the EE encapsulated chitosan/silica nanoparticle (nano-EE) can enhance the amelioration of male infertility...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30240026/nanodcfh-da-a-silica-based-nanostructured-fluorogenic-probe-for-the-detection-of-reactive-oxygen-species
#7
Roger Bresolí-Obach, Luis Busto-Moner, Claudia Muller, Manuel Reina, Santi Nonell
A biocompatible fluorescent nanoprobe for the detection of reactive oxygen species in biological systems has been designed, synthesized and characterized, circumventing some of the limitations of the molecular probe diacetyl 2',7'-dichlorodihydrofluorescein (DCFH-DA). It has been synthetized the nanoparticulate form of DCFH-DA by covalently attaching the widely used fluorescent probe DCFH-DA to a mesoporous silica nanoparticle through a linker. The reactivity of nanoDCFH-DA has been tested toward several reactive oxygen species...
September 21, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/30226508/oxygen-plasmas-a-sharp-chisel-and-handy-trowel-for-nanofabrication
#8
K Bazaka, O Baranov, U Cvelbar, B Podgornik, Y Wang, S Huang, L Xu, J W M Lim, I Levchenko, S Xu
Although extremely chemically reactive, oxygen plasmas feature certain properties that make them attractive not only for material removal via etching and sputtering, but also for driving and sustaining nucleation and growth of various nanostructures in plasma bulk and on plasma-exposed surfaces. In this minireview, a number of representative examples is used to demonstrate key mechanisms and unique capabilities of oxygen plasmas and how these can be used in present-day nano-fabrication. In addition to modification and functionalisation processes typical for oxygen plasmas, their ability to catalyse the growth of complex nanoarchitectures is emphasized...
September 27, 2018: Nanoscale
https://www.readbyqxmd.com/read/30184793/zno-sio-2-nanohybrid-decorated-sustainable-geopolymer-retaining-anti-biodeterioration-activity-with-improved-durability
#9
Manas Sarkar, Moumita Maiti, Soumen Maiti, Shilang Xu, Qinghua Li
Geopolymer, consists of industrial by-product fly ash, and alkaline activator, possesses similar strength along with durability like conventional cement composite, is an alternative construction substantial of Portland cement in current scenario. Corrosion of the concrete materials resulted mainly from the chemical degradation. Besides chemical degradation, biogenic-deterioration is also another alarming issue especially in the sewer systems, bridge piers, several pipelines and offshore platforms and the need to act on it is long-standing...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30174074/antioxidant-response-of-cucumber-cucumis-sativus-exposed-to-nano-copper-pesticide-quantitative-determination-via-lc-ms-ms
#10
Yuxiong Huang, Adeyemi S Adeleye, Lijuan Zhao, Anastasiia S Minakova, Tarun Anumol, Arturo A Keller
Targeted metabolomics aims to provide a new approach to investigate metabolites and gather both qualitative and quantitative information. We describe a protocol for extraction and analysis of plant metabolites, specifically 13 secondary metabolites (antioxidants) using liquid chromatography coupled to triple quadrupole mass spectrometry (LC-MS/MS), with high linearity (R2 > 0.99) and reproducibility (0.23-6.23 R%) with low limits of detection (>0.001 ng/mL) and quantification (>0.2 ng/mL). The protocol was applied to study the antioxidant response of cucumber plants exposed to nanocopper pesticide...
January 1, 2019: Food Chemistry
https://www.readbyqxmd.com/read/30170208/environmental-risks-of-zno-nanoparticle-exposure-on-microcystis-aeruginosa-toxic-effects-and-environmental-feedback
#11
Yulin Tang, Huaijia Xin, Shu Yang, Meiting Guo, Tyler Malkoske, Daqiang Yin, Shengji Xia
The vast majority of studies measure the toxic effect of organisms exposed to nanoparticles (NPs) while there is still a lack of knowledge about the influence of NPs on the aquatic environment. It is unknown whether or not the interaction between NPs and algae will result in the variation of algal organic matter (AOM) and stimulate the production of more algal toxins. In this study, zinc oxide nanoparticles (nano-ZnO) as a typical representative of metal oxide NPs were used to evaluate the toxic effects and environmental feedback of Microcystis aeruginosa...
August 16, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/30125721/mitochondria-targeting-bodipy-loaded-micelles-as-novel-class-of-photosensitizer-for-photodynamic-therapy
#12
Mimi Li, Xia Li, Zhonglian Cao, Yuntong Wu, Ji-An Chen, Jie Gao, Zhijun Wang, Wei Guo, Xianfeng Gu
In this paper, a series of novel BODIPY-based photosensitizers have been designed and synthesized for photodynamic therapy. BODIPY3 was screened out as the most potential photosensitizer due to its excellent optical properties, high singlet oxygen efficiency and good photostability. However, as an organic photosensitizer, BODIPY3 still suffered from the drawbacks of insolubility and instability in aqueous system. In view of these problems, DSPE-PEG2000 was used to trap BODIPY3 into the hydrophobic core of micelles to obtain well-dispersing nano complexes BODIPY3-PEG3 in aqueous system...
September 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30115410/boldine-loaded-plga-nanoparticles-have-improved-efficiency-of-drug-carriage-and-protective-potential-against-cisplatin-induced-toxicity
#13
Jesmin Mondal, Mousumi Patra, Ashis Kumar Panigrahi, Anisur Rahman Khuda-Bukhsh
BACKGROUND: Cisplatin is a widely-used potent anti-cancer drug having severe side-effects precluding its sustained use. OBJECTIVES: Poly (lactide-co-glycolide) (PLGA)-nanoparticles loaded Boldine, an antioxidant ingredient of ethanolic extract of Boldo plant (Peumus boldus) was tested in cancer mice model, Mus musculus to examine if it could reduce unwanted Cisplatin-induced toxicity in normal tissue. MATERIAL AND METHODS: Nano-encapsulation of Boldine was done by following the standardized solvent displacement method...
August 13, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/30102510/tumor-oxygenation-and-hypoxia-inducible-factor-1-functional-inhibition-via-a-reactive-oxygen-species-responsive-nanoplatform-for-enhancing-radiation-therapy-and-abscopal-effects
#14
Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nanosystems to improve tumor oxygenation for immobilizing DNA damage and simultaneously initiate oxygen-dependent HIF-1α degradation. However, HIF-1α degradation is incomplete during tumor oxygenation treatment alone. Therefore, tumor oxygenation combined with residual HIF-1 functional inhibition is crucial to optimizing therapeutic outcomes of radiotherapy...
August 28, 2018: ACS Nano
https://www.readbyqxmd.com/read/30099929/photodynamic-therapy-for-metastatic-melanoma-treatment-a-review
#15
Channay Naidoo, Cherie Ann Kruger, Heidi Abrahamse
This review article is based on specifically targeted nanoparticles that have been used in the treatment of melanoma. According to the Skin Cancer Foundation, within 2017 an estimated 9730 people will die due to invasive melanoma. Conventional treatments for nonmalignant melanoma include surgery, chemotherapy, and radiation. For the treatment of metastatic melanoma, 3 therapeutic agents have been approved by the Food and Drug Administration: dacarbazine, recombinant interferon α-2b, and high-dose interleukin 2...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/30094453/transient-dna-damage-following-exposure-to-gold-nanoparticles
#16
Sarah May, Cordula Hirsch, Alexandra Rippl, Nils Bohmer, Jean-Pierre Kaiser, Liliane Diener, Adrian Wichser, Alexander Bürkle, Peter Wick
Due to their interesting physicochemical properties, gold nanoparticles (Au-NPs) are the focus of increasing attention in the field of biomedicine and are under consideration for use in drug delivery and bioimaging, or as radiosensitizers and nano-based vaccines. Thorough evaluation of the genotoxic potential of Au-NPs is required, since damage to the genome can remain undetected in standard hazard assessments. Available genotoxicity data is either limited or contradictory. Here, we examined the influence of three surface modified 3-4 nm Au-NPs on human A549 cells, according to the reactive oxygen species (ROS) paradigm...
August 23, 2018: Nanoscale
https://www.readbyqxmd.com/read/30090551/nanoparticulate-titanium-dioxide-inhibited-dendritic-development-is-involved-in-apoptosis-and-autophagy-of-hippocampal-neurons-in-offspring-mice
#17
Yingjun Zhou, Fashui Hong, Yusheng Tian, Xiangyu Zhao, Jie Hong, Yuguan Ze, Ling Wang
Background : Numerous studies have demonstrated that, upon maternal exposure, nano-TiO2 can cross the placental barrier, accumulate in offspring animals, and cause neurotoxicity. However, the neurotoxic mechanisms are not fully understood. The aim of this study is to determine the effects of nano-TiO2 on the dendritic outgrowth of hippocampal neurons and confirm the role of apoptosis and excessive autophagy in the neurotoxicity of offspring mice caused by nano-TiO2 , as well as its molecular mechanisms. Methods : Pregnant mice were intragastrically administered 1, 2, or 3 mg per kg body weight nano-TiO2 consecutively from prenatal day 7 to postpartum day 21...
November 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/30086228/photoperiodic-flower-mimicking-metallic-nanoparticles-for-image-guided-medicine-applications
#18
Soojeong Cho, Byeongdu Lee, Wooram Park, Xiaoke Huang, Dong-Hyun Kim
Nanoradiosensitizers have been developed to enhance localization and precision of therapeutic radiation delivery. A specific volume of comprising surface atoms is known to be the radiosensitizing region. However, the shape-dependent local dose enhancement of nanoparticles is often underestimated and rarely reported. Here, a noble metal nanostructure, inspired by the photoperiodic day-flowers, was synthesized by metal reduction with bile acid molecules. The impact of high surface area of day-flower mimicking metallic nanoparticles (D-NP) on radiosensitizing effect was demonstrated with assays for ROS generation, cellular apoptosis, and clonogenic survival of human liver cancer cells (HepG2) cells...
August 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30075845/nano-chemotherapeutic-efficacy-of-epigallocatechin-3-gallate-mediating-apoptosis-in-a549-cells-involvement-of-reactive-oxygen-species-mediated-nrf2-keap1signaling
#19
Bakthavatchalam Velavan, Thomas Divya, Anandasadagopan Sureshkumar, Ganapasam Sudhandiran
Chemotherapeutic drugs exert systemic toxicity in lung cancer cells and therefore novel treatment strategies are warranted. Epigallocatechin 3-gallate (EGCG), though possessing beneficial effects in alleviating cancer, its effect has been limited due to ineffective systemic delivery, toxicity and bioavailability. To attain the maximum therapeutic response of EGCG, we have synthesized bovine serum albumin (BSA) encapsulated magnetite nanoparticle (MNPs) loaded with EGCG (nano EGCG). The synthesized nano EGCG was characterized using HR-TEM, XRD and FT-IR...
September 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30074796/quenching-effects-of-graphene-oxides-on-the-fluorescence-emission-and-reactive-oxygen-species-generation-of-chloroaluminum-phthalocyanine
#20
Alan R Baggio, Mayara S C Santos, Fabiane H V Souza, Rodrigo B Nunes, Paulo Eduardo N Souza, Sônia N Báo, Antonio Otavio T Patrocinio, Detlef W Bahnemann, Luciano P Silva, Maria José A Sales, Leonardo G Paterno
The photophysical behavior and reactive oxygen species (ROS) generation by chloroaluminum phthalocyanine (AlClPc) are evaluated by steady state absorption/emission, transient emission, and electron paramagnetic resonance spectroscopies in the presence of graphene oxide (GO), reduced graphene oxide (RGO), and carboxylated nanographene oxide (NGO). AlClPc and graphene oxides form a supramolecular structure stabilized by π-π interactions, which quantitatively quenches fluorescence emission and suppresses ROS generation...
August 30, 2018: Journal of Physical Chemistry. A
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