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Reactive oxygen nano

Wang Sik Lee, Hyun-Ju Cho, Eungwang Kim, Yang Hoon Huh, Hyo-Jeong Kim, Bongsoo Kim, Taejoon Kang, Jeong-Soo Lee, Jinyoung Jeong
As nano- and micro-sized plastics accumulate in the environment and the food chain of animals, including humans, it is imperative to assess the effects of nanoplastics in living organisms in a systematic manner, especially because of their ability to adsorb potential toxicants such as pollutants, heavy metals, and organic macromolecules that coexist in the environment. Using the zebrafish embryo as an animal model, we investigated the bioaccumulation and in vivo toxicity of polystyrene (PS) nanoplastics individually or in combination with the Au ion...
December 10, 2018: Nanoscale
Khaled Athmouni, Dalel Belhaj, Sana Gammoudi, Abdelfattah El Feki, Habib Ayadi
The nano-encapsulation of Periploca angustifolia phenolic extract using the macrocyclic carbohydrate polymers (β‑cyclodextrins) is a most approach compared with other encapsulation methods. In this work, the β‑Cyclodextrins-PAE complex stability has been evaluated by advanced analytical methods and techniques including HPLC, FTIR and XRD. The results showed that CdCl2 treatment caused a significant decrease in cell viability. The CdCl2 -induced damage in the HepG2 cells were significantly ameliorated (p < 0...
December 3, 2018: International Journal of Biological Macromolecules
Mafalda Pinto, Cristiano Soares, Arlete Santos Pinto, Fernanda Fidalgo
This study aimed to evaluate the effects of nickel oxide nanomaterial (nano-NiO) on goji berry (Lycium barbarum L.) shoots grown under in vitro conditions and to determine if the nanomaterial was more harmful than its bulk counterpart, nickel (II) sulphate (NiSO4 ). For this purpose, in vitro shoots of L. barbarum were cultured on MS medium supplemented with 15 mg L-1 of NiSO4 or nano-NiO. Nano-NiO was more harmful for shoots growth and photosynthetic pigments than NiSO4 , with reductions up to 82% in comparison to the control...
November 20, 2018: Chemosphere
Ye Zhang, April Z Gu, Shanshan Xie, Xiangyang Li, Tianyu Cen, Dan Li, Jianmin Chen
The widespread use of nanoparticles has triggered increasing concern and interest due to the adverse effects on global public health and environmental safety. Whether the presence of nano-metal oxides (NMOs) could facilitate the formation of new antimicrobial resistance genes (ARGs) via de novo mutation is largely unknown. Here, we proved that two widely used NMOs could significantly improve the mutation frequencies of CIP- and CHL-resistant E. coli isolates; however, the corresponding metal ions have weaker effects...
October 25, 2018: Environment International
Xiaoqing Yi, Jun Dai, Yingyan Han, Min Xu, Xiaojin Zhang, Shijie Zhen, Zujin Zhao, Xiaoding Lou, Fan Xia
Combination of photodynamic therapy and chemotherapy has been emerging as a new strategy for cancer treatment. Conventional photosensitizer tends to aggregate in aqueous media, which causes fluorescence quenching, reduces reactive oxygen species (ROS) production, and limits its clinical application to photodynamic therapy. Traditional nanoparticle drug delivery system for chemotherapy also has its disadvantages, such as low drug loading content, drug leakage, and off-target toxicity for normal tissues. Here, we developed a reduction-sensitive co-delivery micelles TB@PMP for combinational therapy, which composed of entrapping a red aggregation-induced emission fluorogen (AIEgen) for photodynamic therapy and PMP that contains a reduction-sensitive paclitaxel polymeric prodrug for chemotherapy...
2018: Communications biology
Hirofumi Kishi, Tomokazu Sakamoto, Koichiro Asazawa, Susumu Yamaguchi, Takeshi Kato, Barr Zulevi, Alexey Serov, Kateryna Artyushkova, Plamen Atanassov, Daiju Matsumura, Kazuhisa Tamura, Yasuo Nishihata, Hirohisa Tanaka
Platinum group metal-free (PGM-free) catalysts based on transition metal-nitrogen-carbon nanomaterials have been studied by a combination of ex situ and in situ synchrotron X-ray spectroscopy techniques; high-resolution Transmission Electron Microscope (TEM); Mößbauer spectroscopy combined with electrochemical methods and Density Functional Theory (DFT) modeling/theoretical approaches. The main objective of this study was to correlate the HO₂- generation with the chemical nature and surface availability of active sites in iron-nitrogen-carbon (Fe-N-C) catalysts derived by sacrificial support method (SSM)...
November 22, 2018: Nanomaterials
Junjie Hu, Wenting Lin, Boji Lin, Kangming Wu, Hongbo Fan, Yingxin Yu
Modified nano-graphene quantum dots (M-GQDs) are widely used in bioimaging, drug delivery, and chemical engineering. Because M-GQDs could induce reactive oxygen species and DNA damage, we hypothesized that M-GQDs modulate DNA methylation. To test this hypothesis, zebrafish were exposed to reduced, hydroxylated, or aminated GQDs (graphene quantum dots) at different concentrations for 7 days; global DNA methylation in liver, gill, and intestine was then studied. M-GQDs induced global DNA hypermethylation in various tissues in a dose-dependent manner...
November 19, 2018: Ecotoxicology and Environmental Safety
Eskandar Moghimipour, Mohsen Rezaei, Maryam Kouchak, Zahra Ramezani, Mohsen Amini, Kambiz Ahmadi Angali, Sadegh Saremy, Farid Abedin Dorkoosh, Somayeh Handali
This study was performed to prepare 5-fluorouracil (5FU) containing targeted liposomes for the safety and efficacy enhancement. Liposomes were prepared using thin layer method and transferrin (Tf) was employed as the targeting ligand. Morphology of 5FU-loaded liposomes was assessed by transmission electron microscopy (TEM). The in vitro cytotoxicity was investigated via MTT assay on HT-29, CT26 and fibroblast cells. Mitochondrial membrane and cell death evaluations were also investigated. Resulted showed that the encapsulation efficiency (EE%) and particle size of the liposomes were 40...
November 16, 2018: Journal of Microencapsulation
Zhuoran Wu, Haibo Yang, Gautam Archana, Moumita Rakshit, Kee Woei Ng, Chor Yong Tay
Zinc oxide nanoparticles (Nano-ZnO) is currently one of the most extensively used inorganic particles in a wide range of skin care and consumable products. Therefore, examining the biological effects of Nano-ZnO, especially in the non-cytotoxic levels, thus holds important contemporary practical implications. Herein, our study demonstrates that long-term conditioning of human keratinocytes (HaCaTs) to non-cytoxic dose of Nano-ZnO (∼100 nm) can induce an adaptive response, leading to an enhancement of the cells tolerance against cytotoxic level of Nano-ZnO...
November 15, 2018: Nanotoxicology
Janel Kydd, Rahul Jadia, Prakash Rai
Polymer-based nanoparticles (NPs) are useful vehicles in treating glioblastoma because of their favorable characteristics such as small size and ability to cross the blood⁻brain barrier, as well as reduced immunogenicity and side effects. The use of a photosensitizer drug such as Verteporfin (BPD), in combination with a pan-vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI), Cediranib (CED), encapsulated in NPs will provide the medical field with new research on the possible ways to treat glioblastoma...
November 10, 2018: Pharmaceutics
Qin Feng, Ningwei Zhao, Wenkai Xia, ChengJie Liang, Guoxin Dai, Jian Yang, Jingxia Sun, Lanying Liu, Lan Luo, Jie Yang
Acetaminophen (APAP) overdose-induced acute liver injury (AILI) is a significant clinical problem worldwide, the hepatotoxicity mechanisms are well elucidated, but the factors involved in the necrosis and repair still remain to be investigated. APAP was injected intraperitoneally in male Institute of Cancer Research (ICR) mice. Quantitative proteome analysis of liver tissues was performed by 2-nitrobenzenesulfenyl tagging, two-dimensional-nano high-performance liquid chromatography separation, and matrix-assisted laser desorption/ionization-time of flight mass spectrometry analysis...
November 11, 2018: Journal of Cellular Physiology
David S Humphrey, Chi L Pang, Qiao Chen, Geoff Thornton
Electron stimulated modifications of the rutile TiO2 (110) surface have been investigated using scanning tunnelling microscopy tip pulses and electron beam irradiation. Tip pulses on the 'as-prepared' surface induce local surface reconstruction and removal of surface hydroxyls in a region around the reconstruction. A defocused beam from an electron gun as well as tip pulses have been used to generate a number of oxygen deficient surfaces. All tip pulse features display an oval profile, which can be attributed to the anisotropic conductivity of the TiO2 (110) surface...
January 11, 2019: Nanotechnology
Yang Zhang, Cai-Xia Wang, Shi-Wen Huang
Photodynamic therapy (PDT) is a noninvasive treatment for selectively killing malignant tumor cells. The photosensitizer is a necessary component of photodynamic nanomedicine. Many efforts have been made to develop new photosensitizers for efficient cancer photodynamic therapy. In this work, we report a novel nano photosensitizer, polymeric micelles (AIE-M) with aggregation induced emission characteristic, for photodynamic cancer therapy. AIE-M with sub-20 nm particle size is prepared by the self-assembly of salicylaldazine-incorporated amphiphilic polymer (AIE-1), which can produce reactive oxygen species (ROS) with light irradiation in solution...
November 7, 2018: Nanomaterials
Wei Ren, Huizi Sha, Jing Yan, Puyuan Wu, Ju Yang, Rutian Li, Hang Zhang, Lixia Yu, Hanqing Qian, Baorui Liu
Paclitaxel is widely used as a radiosensitizer for various tumors, including esophageal cancer, but its therapeutic effect remains to be improved. In this study, we constructed a novel nano-radiosensitizer, anti-EGFR-iRGD-conjugated (iE)-PRNPs, by conjugating the recombinant protein anti-epidermal growth factor receptor (EGFR)-internalizing arginine-glycine-aspartic (iRGD) to the surface of paclitaxel-loaded red blood cell membrane nanoparticles (PRNPs). The iE-PRNPs were confirmed to possess tumor-targeting, high penetrability, and sustained release properties that free paclitaxel does not possess...
November 2018: Journal of Biomaterials Applications
Tian Tian, Sen Qiao, Cong Yu, Jiti Zhou
The responses of methanogenic propionate and butyrate degradation to nano-sized MnO2 exposure were explored. The results showed that supplementation with 50 mg/g volatile suspended solids (VSS) of nano-sized MnO2 significantly enhanced the production rate of CH4 in propionate and butyrate degradation by 25.6% and 21.7%, respectively. The stimulatory effects most likely resulted from enhancements in the microbial metabolic activity based on the observed increases in the extracellular polymeric substance (EPS) secretion and activity of the electron transport system...
October 1, 2018: Journal of Hazardous Materials
Usman Farooq, Muhammad Danish, Shuguang Lyu, Mark L Brusseau, Mengbin Gu, Waqas Qamar Zaman, Zhaofu Qiu, Qian Sui
The surface properties of nanocomposites are influenced by the existence of inorganic species that may affect its performance for specific catalytic applications. The impact of different ionic species on particular catalytic activity had not been investigated to date. In this study, the surface charge (zeta potential) of graphene-oxide-supported nano zero valent iron (G-nZVI) was tested in definitive cationic (Na+ , K+ , Ca2+ and Mg2+ ) and anionic (Br- , Cl- , NO3 - , SO4 2- , and HCO3 - ) environments. The efficiency of G-nZVI catalyst was inspected by measuring the generation of reactive oxygen species (ROS) for the degradation of 1,1,1-trichloroethane (TCA) in sodium percarbonate (SPC) system...
February 15, 2019: Science of the Total Environment
Tareq W M Amen, Osama Eljamal, Ahmed M E Khalil, Nobuhiro Matsunaga
Nowadays, trends in wastewater treatment by zero-valent iron (ZVI) were turned to use bimetallic NZVI particles by planting another metal onto the ZVI surface to increase its reactivity. Nano size zero-valent iron/copper (NZVI/Cu0 ) bimetallic particles were synthesized in order to examine its toxicity effects on the wastewater microbial life, kinetics of phosphorus, ammonia stripping and the reduction of chemical oxygen demand (COD). Various concentrations of NZVI/Cu0 and operation conditions both aerobic and anaerobic were investigated and compared with pure NZVI experiment...
December 2018: Journal of Environmental Sciences (China)
Zhe Zhang, Na Niu, Xi Gao, Fuqin Han, Zhijun Chen, Shujun Li, Jian Li
Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrier (named as FeSiAuO) containing Fe3 O4 , mesoporous SiO2 and Au2 O3 with magnetic, large surface ratio and light induced oxygen production properties...
October 5, 2018: Colloids and Surfaces. B, Biointerfaces
Rengarajan Baskaran, Junghan Lee, Su-Geun Yang
Background: Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases. Introduction: In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues...
2018: Biomaterials Research
Jaroslav Semerád, Monika Čvančarová, Jan Filip, Josef Kašlík, Jana Zlotá, Jana Soukupová, Tomáš Cajthaml
Nano-scale zero-valent iron (nZVI) began attracting research attention in remediation practice in recent decades as a prospective nanomaterial applicable to various contaminated matrices. Despite concerns about the negative effects of nanomaterials on ecosystems, the number of reliable toxicity tests is limited. We have developed a test based on the evaluation of oxidative stress (OS). The test employed the analysis of a typical OS marker (malondialdehyde, MDA), after exposure of six bacterial strains to the tested nanomaterial...
December 2018: Chemosphere
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