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https://www.readbyqxmd.com/read/30531016/implications-of-alpha-synuclein-nitration-at-tyrosine-39-in-methamphetamine-induced-neurotoxicity-in-vitro-and-in-vivo
#1
Hong-Hua Qiao, Lin-Nan Zhu, Yue Wang, Jia-Liang Hui, Wei-Bing Xie, Chao Liu, Ling Chen, Ping-Ming Qiu
Methamphetamine is an amphetamine-type psychostimulant that can damage dopaminergic neurons and cause characteristic pathological changes similar to neurodegenerative diseases such as Parkinson's disease. However, its specific mechanism of action is still unclear. In the present study, we established a Parkinson's disease pathology model by exposing SH-SY5Y cells and C57BL/6J mice to methamphetamine. In vitro experiments were performed with 0, 0.5, 1.0, 1.5, 2.0 or 2.5 mM methamphetamine for 24 hours or 2.0 mM methamphetamine for 0-, 2-, 4-, 8-, 16-, and 24-hour culture of SH-SY5Y cells...
February 2019: Neural Regeneration Research
https://www.readbyqxmd.com/read/30530055/synthesis-of-anticorrosion-nanohybrid-films-based-on-bioinspired-dopamine-l-cys-cnt-pda-through-self-assembly-on-304-stainless-steel-in-3-5-nacl
#2
Fatemeh Elmi, Elahe Valipour, Shahram Ghasemi
Nanohybrid films containing multiwalled carbon nanotubes (MWCNTs) were successfully coated on 304-stainless steel (304ss) for anti-corrosion use. The nanocompositewas made by a self-assembly of poly (dopamine), wrapped with MWCNTs (CNT@PDA) through a mussel inspired method. In order to enhance the corrosion protection, an inner layer of L-cysteine, an adhesive amino acid to 304ss surface through thiol (-SH) functional group were constructed through a dip-coating process. Potentiodynamic polarization measurements and electrochemical impedance spectroscopy revealed that the double nano-layer could act as a noble anticorrosive coating in 3...
November 30, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/30474965/nanostructured-thermo-responsive-surfaces-engineered-via-stable-immobilization-of-smart-nanogels-with-assistance-of-polydopamine
#3
Lei Zhang, Zhuang Liu, Lu-Yue Liu, Jun-Li Pan, Feng Luo, Chao Yang, Rui Xie, Xiao-Jie Ju, Wei Wang, Liang-Yin Chu
Thermo-responsive surfaces featured with nanostructures have found wide potential applications in biological and chemical fields. Herein, we report nanostructured thermo-responsive surfaces engi-neered via stable immobilization of thermo-responsive nanogels with assistance of polydopamine. The results show that the thin layer of polydopamine on the poly(N-isopropylacrylamide) (PNIPAM) nanogels nearly does not affect the thermo-responsive property of the nanogels. The stability of thermo-responsive nanogels on the substrate surfaces immobilized under different pH conditions of dopamine solutions are quatitively studied by fluid shearing experiments inside capil-laries, and the characterization results show that the strong interaction forces between the polydo-pamine layer on the substrate surfaces and the thermo-responsive nanogels are heavily depended on the oxidation state of dopamine molecules...
November 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30466349/mussel-inspired-in-situ-forming-adhesive-hydrogels-with-anti-microbial-and-hemostatic-capacities-for-wound-healing
#4
Xiaoman Han, Guihua Meng, Qian Wang, Lin Cui, Hao Wang, Jianning Wu, Zhiyong Liu, Xuhong Guo
All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-γ-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-γ-poly glutamic acid (CSE-PD) hydrogel...
November 22, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/30461214/the-ppar%C3%AE-agonist-fenofibrate-attenuates-disruption-of-dopamine-function-in-a-maternal-immune-activation-rat-model-of-schizophrenia
#5
Marta De Felice, Miriam Melis, Sonia Aroni, Anna Lisa Muntoni, Silvia Fanni, Roberto Frau, Paola Devoto, Marco Pistis
AIMS: Prenatal maternal immune activation (MIA) is associated with a risk to develop schizophrenia and affects dopamine systems in the ventral tegmental area (VTA), key region in the neurobiology of psychoses. Considering the well-described sex differences in schizophrenia, we investigated whether sex affects MIA impact on dopamine system and on schizophrenia-related behavioral phenotype. Furthermore, considering peroxisome proliferator-activated receptor-α (PPARα) expression in the CNS as well as its anti-inflammatory and neuroprotective properties, we tested if PPARα activation by prenatal treatment with a clinically available fibrate (fenofibrate) may mitigate MIA-related effects...
November 21, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/30402646/fabrication-of-sub-20-nm-patterns-using-dopamine-chemistry-in-self-aligned-double-patterning
#6
Yinyong Li, Jaewon Choi, Zhiwei Sun, Thomas P Russell, Kenneth R Carter
A self-aligned double patterning approach using a dopamine chemistry-inspired coating technique has been developed for the fabrication of sub-20 nm patterns. Poly(methyl methacrylate) (PMMA) films were patterned by nanoimprint lithography to form relief features. A thin layer of polydopamine (PDA) was conformally deposited on the surface of the PMMA pattern sidewalls to form a spacer layer. After etching the surface of the PDA layer from the horizontal surfaces and subsequently removing the PMMA template, free-standing PDA sidewall patterns remained that essentially doubled the original PMMA pattern density with decreased feature dimensions as compared to the initial PMMA template structures...
November 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/30385548/poly-adp-ribose-drives-pathologic-%C3%AE-synuclein-neurodegeneration-in-parkinson-s-disease
#7
Tae-In Kam, Xiaobo Mao, Hyejin Park, Shih-Ching Chou, Senthilkumar S Karuppagounder, George Essien Umanah, Seung Pil Yun, Saurav Brahmachari, Nikhil Panicker, Rong Chen, Shaida A Andrabi, Chen Qi, Guy G Poirier, Olga Pletnikova, Juan C Troncoso, Lynn M Bekris, James B Leverenz, Alexander Pantelyat, Han Seok Ko, Liana S Rosenthal, Ted M Dawson, Valina L Dawson
The pathologic accumulation and aggregation of α-synuclein (α-syn) underlies Parkinson's disease (PD). The molecular mechanisms by which pathologic α-syn causes neurodegeneration in PD are not known. Here, we found that pathologic α-syn activates poly(adenosine 5'-diphosphate-ribose) (PAR) polymerase-1 (PARP-1), and PAR generation accelerates the formation of pathologic α-syn, resulting in cell death via parthanatos. PARP inhibitors or genetic deletion of PARP-1 prevented pathologic α-syn toxicity. In a feed-forward loop, PAR converted pathologic α-syn to a more toxic strain...
November 2, 2018: Science
https://www.readbyqxmd.com/read/30329188/dynamic-nitroxide-functional-materials
#8
Hendrik Woehlk, Andrea Lauer, Vanessa Trouillet, Alexander Welle, Leonie Barner, James P Blinco, Kathryn E Fairfull-Smith, Christopher Barner-Kowollik
We introduce a substrate-independent and versatile coating platform for (spatially resolved) surface functionalizations based on nitroxide radical coupling (NRC) reactions and the formation of thermo-labile dynamic covalent alkoxyamine switches. Nitroxide decorated poly(glycidyl methacrylate) (PGMA) microspheres, obtained through bioinspired copolymer surface deposition using dopamine and a nitroxide functional dopamine derivative as monomers, were conjugated with small functional groups in a rewritable, dynamic covalent process...
October 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30318214/dopamine-induced-functionalization-of-cellulose-nanocrystals-with-polyethylene-glycol-towards-poly-l-lactic-acid-bionanocomposites-for-green-packaging
#9
Le Li, Rui-Ying Bao, Tao Gao, Zheng-Ying Liu, Bang-Hu Xie, Ming-Bo Yang, Wei Yang
Improving the physical properties of biobased polymers using bionanofillers is essential to preserve its biodegradability. This work presents a dopamine-induced functionalization of cellulose nanocrystals (CNCs) with polyethylene glycol (PEG), to enhance the crystallization, mechanical and barrier properties of poly(L -lactic acid) (PLLA) bionanocomposites. The effect of molecular weight of grafted PEG on the properties of PLLA is also studied. PEGylation of CNCs significantly enhance the crystallization of PLLA, especially for CNCs functionalized with PEG of lower molecular weight, which lead to balanced strength and ductility, and 66...
January 1, 2019: Carbohydrate Polymers
https://www.readbyqxmd.com/read/30223244/polydopamine-particles-as-nontoxic-blood-compatible-antioxidant-and-drug-delivery-materials
#10
Nurettin Sahiner, Selin Sagbas, Mehtap Sahiner, Diane A Blake, Wayne F Reed
Herein, the potential biomedical application of poly(3,4-dihyroxyphenyl)ethylamine, (poly(dopamine)-p(DA)) particles is reported. P(DA) particles with the size about 100 nm, 18.05 m2 /g specific surface area, and mesoporous structure (7.19 nm pore width) were prepared and shown to be chemically modifiable using chlorosulfonic acid (CSA) and 3-CHloro-2 hydroxypropyl) trimethylammonium chloride solution (CHPACl) to obtain sulfonic acid and quaternary amine group containing modified p(DA) particles, m-p(DA)-CSA and m-p(DA)-CHPACl particles, respectively...
September 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30218990/mussel-inspired-antifouling-magnetic-activated-carbon-for-uranium-recovery-from-simulated-seawater
#11
Feifei Zhang, Hongsen Zhang, Rongrong Chen, Qi Liu, Jingyuan Liu, Cheng Wang, Zhiyao Sun, Jun Wang
Undesirable bio-adhesion of microalgae on adsorbent can influence its adsorption capacity. In this report, we fabricated a novel mussel-inspired antifouling magnetic activated carbons which derived orange peel by integrated biosorption-pyrolysis process (MACs@PDA-Ag), via co-functionalization of poly-dopamine (PDA) and Ag nanoparticles (AgNPs), for the recovery of uranium (VI) from simulated seawater with antimicrobial adhesion performance; this process did not require an additional reducing agent. The effect of pH, concentration, contact time, fouling test against nitzschia closterium f...
January 15, 2019: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30209742/lipase-immobilization-on-high-water-adsorbing-capacity-bagasse-applications-in-bio-based-plasticizer-synthesis
#12
Caixia Cui, Di Cai
This study investigates the structure and water adsorbing capacity of bagasse and of sodium hydroxide pretreated bagasse. The structures of bagasse and bagasse-NaOH were compared by SEM and XRD. Candida antarctica lipase B was then immobilized on bagasse, bagasse-NaOH and DPA@bagasse-NaOH. The expressed activity and immobilization yield of lipase immobilized on bagasse-NaOH (1.0%) was 36% and 45% higher than that on bagasse. When dopamine (DPA) was used as cationic polymer monomer via self-polymerization for mediating immobilization, the protein loading amounts and activity of lipase immobilized on DPA@bagasse-NaOH were higher than that of bagasse-NaOH...
September 12, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30195002/ultrasensitive-immunoassay-of-tumor-protein-ca-15-3-in-mcf-7-breast-cancer-cell-lysates-and-unprocessed-human-plasma-using-gold-nanoparticles-doped-on-the-structure-of-mesoporous-silica
#13
Mohammad Hasanzadeh, Elham Solhi, Mohsen Jafari, Ahad Mokhtarzadeh, Jafar Soleymani, Abolghasem Jouyban, Soltanali Mahboob
Breast cancer is the most common threat in women worldwide. Increasing death rate of diagnosed cases is the main leading cause of designing specific immunoassay for tumor marker in breast cancer. Cancer antigen 15-3 (CA 15-3) is a tumor protein for many types of cancer, most notably breast cancer. Herein, we report a sandwich-type electrochemical immunosensor based on signal amplification strategy of multiple nanocomposites to detection of CA 15-3 biomarker. The proposed immunosensor fabricated by reduced graphene oxide (rGO), poly-dopamine (PDA) and amino functionalized mesoporous silica (MCM-41-NH2 ) doped by gold nanoparticles composite on the glassy carbon electrode with a large surface area which was prepared a new platform to immobilization of primary antibodies and provide excellent conductivity...
December 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30194999/application-of-chitosan-as-biocompatible-polysaccharide-in-quantification-of-some-benzodiazepines-affecting-sleep-disorders-a-new-platform-for-preparation-of-bioactive-scaffolds
#14
Hamideh Ashrafi, Mohammad Hasanzadeh, Khalil Ansarin, Sibel Ayşil Ozkan, Abolghasem Jouyban
Herein, a reusable and time-saving strategy for the electrochemical polymerization of dopamine (EPD) in the presence of chitosan is reported. In this work, biocompatible polymer chitosan (CS) was electrodeposited on the surface of PDA modified glassy carbon electrode using layer-by-layer strategy. Owing to the abundant catechol and amine groups in the PDA layer, uniform gold nanoparticles (Au NPs) are deposited onto the POLY(DA-CS) and can effectively prevent the recombination of electron-hole pairs generated from photo-electrocatalysis and transfer the captured electrons to participate in the electrocatalytic reaction process...
December 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30193634/evaluation-of-boronate-affinity-solid-phase-extraction-coupled-in-line-to-capillary-isoelectric-focusing-for-the-analysis-of-catecholamines-in-urine
#15
Maria Betzabeth Espina-Benitez, Fabienne Marconi, Jérôme Randon, Claire Demesmay, Vincent Dugas
In this study, a new miniaturized and integrated analytical system was developed based on the in-line coupling of boronate affinity solid phase extraction with capillary isoelectric focusing separation and UV detection. This original coupling takes advantage of the selective enrichment of cis-diol-containing compounds using a boronate affinity sorbent and the exceptional focusing features of isoelectric focusing process. Such coupling has been used for preconcentration/purification and separation of urinary catecholamines (dopamine, adrenaline and noradrenaline) as proof of concept...
November 30, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30184801/construction-and-characterization-of-an-antibacterial-anticoagulant-dual-functional-surface-based-on-poly-l-lactic-acid-electrospun-fibrous-mats
#16
Wufeng Yang, Keke Wu, Xiaoyan Liu, Yanpeng Jiao, Changren Zhou
In this study, a poly l-lactic acid (PLLA) fibrous mat was prepared by electrospinning, followed by surface modification with polydopamine (PDA), based on its strong adhesion performance and self-polymerization of dopamine. The PDA coating on the fibrous mat surface provided a reaction platform for heparin via a Michael-type addition reaction and a reductive surface for Ag+ in situ formation of silver nanoparticles (AgNPs) in AgNO3 solution. The structure and chemical composition of the fibrous mats were determined by scanning electronic microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30183312/melanin-precursor-influence-on-structural-colors-from-artificial-melanin-particles-polydopa-polydopamine-and-polynorepinephrine
#17
Takeshi Iwasaki, Yuki Tamai, Mikiya Yamamoto, Tatsuo Taniguchi, Keiki Kishikawa, Michinari Kohri
Polydopamine (PDA) is of interest as a mimetic material of melanin to produce structural color materials. Herein, to investigate the influence of the material composition of the artificial melanin particles on structural color, we demonstrated the preparation of core-shell particles by polymerization of norepinephrine or 3,4-dihydroxyphenylalanine, which are melanin precursors similar to dopamine, in the presence of polystyrene particles. It was revealed that the arrays of the prepared particles produce high-visibility structural color because of absorption of scattering light...
October 2, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/30172152/mussel-inspired-preparation-of-layered-double-hydroxides-based-polymer-composites-for-removal-of-copper-ions
#18
Jibo Dou, Qiang Huang, Hongye Huang, Defu Gan, Junyu Chen, Fengjie Deng, Yuanqing Wen, Xiaoli Zhu, Xiaoyong Zhang, Yen Wei
A novel ternary composite consisting of Mg/Al layered double hydroxides (LDH), polydopamine (PDA) and poly(methyl vinyl ether-alt-maleic anhydride) (PMVE-MA) was fabricated by a facile combination of mussel-inspired chemistry and a ring-opening reaction. Dopamine can serve as a "minimalist mimic" of mussel adhesive protein to form a layer of polydopamine (PDA) on the LDH surface under rather mild conditions (including air atmosphere, aqueous solution, and catalyst free). Subsequently, the PMVE-MA brushes were immobilized onto the PDA modified LDH via a ring-opening reaction...
January 1, 2019: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30168310/gradient-polydopamine-coating-a-simple-and-general-strategy-toward-multishape-memory-effects
#19
Yuan Wei, Xiaodong Qi, Shiwen He, Shihao Deng, Dingyao Liu, Qiang Fu
Multi shape memory polymers (multi-SMPs) exhibit many potential applications such as aerospace, soft robotics, and biomedical devices because of their unique abilities. Although many works are done to broaden the preparations of multi-SMPs, the desire to a simple and versatile strategy as well as more complex shapes still exists. Moreover, a light-induced SMP shows more advantages than a thermal-induced one in many practical working circumstances. Herein, inspired by strong adhesion and efficient photothermal conversion of polydopamine (PDA) coating, we report a more simple and facile approach to prepare light-induced multi-SMPs by introducing a gradient PDA coating on a dual-SMP through time-controlled dipping...
September 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30167981/a-glassy-carbon-electrode-modified-with-a-composite-consisting-of-gold-nanoparticle-reduced-graphene-oxide-and-poly-l-arginine-for-simultaneous-voltammetric-determination-of-dopamine-serotonin-and-l-tryptophan
#20
Md Zaved H Khan, Xiaoqiang Liu, Yunfei Tang, Jinhua Zhu, Weiping Hu, Xiuhua Liu
A glassy carbon electrode (GCE) was modified with poly(L-arginine) (P-Arg), reduced graphene oxide (rGO) and gold nanoparticle (AuNP) to obtain an electrode for simultaneous determination of dopamine (DA), serotonin (5-HT) and L-tryptophan (L-Trp) in the presence of ascorbic acid (AA). The modified GCE was prepared via subsequent 'layer-by-layer' deposition using an electrochemical technique. The surface morphology of the modified electrode was studied by scanning electron microscopy, and electrochemical characterizations were carried out via cyclic voltammetry and electrochemical impedance spectroscopy...
August 30, 2018: Mikrochimica Acta
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