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Poly dopamine

Yunchuan Xie, Wanrong Jiang, Tao Fu, Jingjing Liu, Zhicheng Zhang, Shengnan Wang
Poor compatibility of polymer/ceramic composites used as high-pulse capacitors with high permittivity suffers from the reduced breakdown strength (Eb) and lowered energy density (Ue). Herein, mussels-inspired poly(dopamine) (PDA) modified BaSrTiO3 nanoparticle (mBST) and PVDF matrix are bonded together to fabricate nanocomposites with crosslinked 3D network and enhanced compatibility. The significantly improved Eb of 466 MV/m and the highest Ue of 11.0 J/cm3 for PVDF-based polymer/BST composites have been obtained...
August 8, 2018: ACS Applied Materials & Interfaces
Jingxuan Cai, Cuiping Zhang, Arshad Khan, Liqiu Wang, Wen-Di Li
The authors report a new patterned electroless metallization process for creating micro- and nanoscale metallic structures on polymeric substrates, which are essential for emerging flexible and stretchable optical and electronic applications. This novel process features a selective adsorption of catalytic Pd nanoparticles (PdNPs) on a lithographically masked poly(dopamine) (PDA) interlayer in-situ polymerized on the substrates. The moisture-resistant PDA layer has excellent stability under harsh electroless plating bath, which enables electroless metallization on versatile substrate materials regardless of their hydrophobicity, and significantly strengthens the attachment of electroless plated metallic structures on the polymeric substrates...
August 7, 2018: ACS Applied Materials & Interfaces
Maria Jose York-Duran, Pramod Kumar Ek, Maria Godoy-Gallardo, Leticia Hosta-Rigau
Advanced multicompartment drug delivery platforms ensure the co-localization of several drugs within the same carrier, thus making it possible to achieve a more effective and safe therapeutic outcome. Herein, we report a novel multicompartment architecture by combining two intrinsically different systems, i.e., polymeric microgels and liposomes, with the aim to achieve different release kinetics for model compounds. We assemble poly(N-isopropylacrylamide-co-acrylic acid) microgels decorated with liposomes which are subsequently coated with a protective poly(dopamine) shell and a poly(ethylene glycol) (PEG) layer...
July 17, 2018: Colloids and Surfaces. B, Biointerfaces
Hyesun Hyun, Joonyoung Park, Kiela Willis, Ji Eun Park, L Tiffany Lyle, Wooin Lee, Yoon Yeo
Albumin is a promising surface modifier of nanoparticulate drug delivery systems. Serving as a dysopsonin, albumin can protect circulating nanoparticles (NPs) from the recognition and clearance by the mononuclear phagocytic system (MPS). Albumin may also help transport the NPs to solid tumors based on the increased consumption by cancer cells and interactions with the tumor microenvironment. Several studies have explored the benefits of surface-bound albumin to enhance NP delivery to tumors. However, it remains unknown how the surface modification process affects the conformation of albumin and the performance of the albumin-modified NPs...
July 18, 2018: Biomaterials
D Sangamithirai, S Munusamy, V Narayanan, A Stephen
Dopamine (DA) and Folic acid (FA) are co-existing compounds in biological fluids that plays a vital role in central nervous system and human metabolism. DA is an important neurotransmitter in the brain's neural circuits and its diminution often results in Parkinson's disease. Folate is another form of folic acid, which is known as one of the B vitamins. It is utilized as an additive by women during pregnancy in order to prevent the neural tube defects. The present study reports on the fabrication of electrochemical sensor for the simultaneous determination of DA and FA using poly(o-methoxyaniline)-gold (POMA-Au) nanocomposite...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Taira Kajisa, Wei Li, Tsuyoshi Michinobu
A highly sensitive catecholamine (CA) sensor was created using a biointerface layer composed of a biopolymer and a potentiometric detection device. For the detection of CAs, 3-aminophenylboronic acid (3-NH2 -PBA) was reacted with the carboxyl side chain of l-3,4-dihydroxyphenylalanine (l-dopa, LD) and the PBA-modified l-dopa was directly copolymerized with LD on an Au electrode, resulting in a 3.5 nm thick PBA-modified poly(PBA-LD/LD) layer-coated Au electrode. By connecting the PBA-LD-coated Au electrode to a field-effect transistor (FET), the molecular charge changes at the biointerface of the Au electrode, which was caused by di-ester binding of the PBA-CA complex, were transduced into gate surface potential changes...
June 30, 2018: ACS Omega
Aravindan Aashish, Neethu Kalloor Sadanandhan, Krishna Priya Ganesan, Unnikrishnan Nair Saraswathy Hareesh, Sankaran Muthusamy, Sudha J Devaki
We have designed a flexible electrochemical transducer film based on PEDOT-titania-poly(dimethylsiloxane) (PTS) for the simultaneous detection of neurotransmitters. PTS films were characterized using various techniques such as transmission electron microscopy, scanning electron microscopy, atomic force microscopy, four probe electrical conductivity, ac-impedance, and thermomechanical stability. The electrocatalytic behavior of the flexible PTS film toward the oxidation of neurotransmitters was investigated using cyclic voltammetry and differential pulse voltammetry...
March 31, 2018: ACS Omega
Neha Thakur, Subhasis Das Adhikary, Mukesh Kumar, Daisy Mehta, Anil K Padhan, Debaprasad Mandal, Tharamani C Nagaiah
A novel sandwich polyoxometalate (POM) Na12 [WCo3 (H2 O)2 (CoW9 O34 )2 ] and poly(vinylimidazolium) cation [PVIM+ ] in combination with nitrogen-doped carbon nanotubes (NCNTs) was developed for a highly selective and ultrasensitive detection of dopamine. Conductively efficient heterogenization of Co5 POM catalyst by PVIM over NCNTs provides the synergy between PVIM-POM catalyst and NCNTs as a conductive support which enhances the electron transport at the electrode/electrolyte interface and eliminates the interference of ascorbic acid (AA) at physiological pH (7...
March 31, 2018: ACS Omega
Bo Peng, Xinyi Lai, Lei Chen, Xuemei Lin, Chengxin Sun, Lixin Liu, Shaohai Qi, Yongming Chen, Kam W Leong
Burn, trauma, and various medical conditions including bacterial infection, diabetes complication, and surgery could lead to an acute cutaneous wound and scar formation. Application of tissue glues instead of sutures could minimize the additional trauma and scar formation. Despite the countless efforts devoted to the development of high-strength tissue glues, little attention has been paid to their influence on the scar formation. Here, we report the development of a new tissue glue with excellent biocompatibility and tunable degradability for scarless wound closure...
September 30, 2017: ACS Omega
Chun-Hao Su, Chia-Liang Sun, Ying-Chih Liao
In this study, an effective and simple direct printing method was developed to create sensing devices on screen-printed carbon electrodes (SPCEs) to detect multiple species simultaneously. Two sensing materials, graphene oxide nanoribbons (GONRs) and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), were printed on one SPCE for detection of multiple biochemical substances. Printed layers of the GONRs and PEDOT:PSS mixture (GONRs & PEDOT:PSS) on SPCE showed embedment of GONRs in the PEDOT:PSS layer and diminished the electrochemical activity of GONRs...
August 31, 2017: ACS Omega
Wei Luan, Luke Alexander Hammond, Stephanie Vuillermot, Urs Meyer, Darryl Walter Eyles
Dysfunction in dopamine (DA) systems is a prominent feature in schizophrenia patients and may result from the abnormal development of mesencephalic (mes)DA systems. Maternal immune activation (MIA) and developmental vitamin D (DVD)-deficiency both induce schizophrenia-relevant dopaminergic abnormalities in adult offspring. In this study, we investigated whether maternal administration of the vitamin D hormone (1,25OHD, VITD ) could prevent MIA-induced abnormalities in DA-related behaviors and mesDA development...
June 27, 2018: Scientific Reports
David Juriga, Istvan Laszlo, Krisztina Ludanyi, Imre Klebovich, Chae Chang Hoon, Miklos Zrinyi
Preparation of novel biocompatible and biodegradable polymer based prodrugs that can be applied in complex drug delivery systems is one of the most researched fields in pharmaceutics. The kinetics of the drug release strongly depends on the physicochemical parameters of prodrugs as well as environmental properties, therefore precise kinetical description is crucial to design the appropriate polymer prodrug formula. The aim of the present study was to investigate the dopamine release from different poly(aspartamide) based dopamine drug conjugates in different environments and to work out a kinetic description which can be extended to describe drug release in similar systems...
June 22, 2018: Acta Biomaterialia
Yanfei Ma, Shuanhong Ma, Yang Wu, Xiaowei Pei, Stanislav N Gorb, Zuankai Wang, Weimin Liu, Feng Zhou
Despite extensive efforts to mimic the fascinating adhesion capability of geckos, the development of reversible adhesives underwater has long been lagging. The appearance of mussels-inspired dopamine chemistry has provided the feasibility to fabricate underwater adhesives; however, for such a system, imitating the reversible and fast dynamic attachment/detachment mechanism of gecko feet still remains unsolved. Here, by synthesizing a thermoresponsive copolymer of poly(dopamine methacrylamide-co-methoxyethyl-acrylate-co-N-isopropyl acrylamide) and then decorating it onto mushroom-shaped poly(dimethylsiloxane) pillar arrays, a novel underwater thermoresponsive gecko-like adhesive (TRGA) can be fabricated, yielding high adhesion during the attachment state above the lower critical solution temperature (LCST) of the copolymer, yet low adhesion during the detachment state below the LCST of the copolymer...
June 19, 2018: Advanced Materials
He-Lin Xu, Zi-Liang Fan, De-Li ZhuGe, Meng-Qi Tong, Bi-Xin Shen, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Yasin Sohawon, Qing Yao, Ying-Zheng Zhao
Currently, combination drug therapy is one of the most effective approaches to glioma treatment. However, due to the inherent dissimilar pharmacokinetics of individual drugs and blood brain barriers, it was difficult for the concomitant drugs to simultaneously be delivered to glioma in an optimal dose ratio manner. Herein, a cationic micellar core (Cur-M) was first prepared from d-α-tocopherol-grafted-ε-polylysine polymer to encapsulate the hydrophobic curcumin, followed by dopamine-modified-poly-γ-glutamic acid polymer further deposited on its surface as a anion shell through pH-sensitive linkage to encapsulate the hydrophilic doxorubicin (DOX) hydrochloride...
November 2018: Drug Delivery
Long Huang, Meiying Liu, Hongye Huang, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Melanins are well-known biopolymers that are ubiquitous in nature, distributed widely in microorganisms, plants, and animals, and play significant physiological roles. They are mostly biopolymers formed from phenolic compounds by polymerization via quinones. Poly(dopamine) (PDA), a melanin-like material, is similar in structure and properties to eumelanin and has attracted considerable interest for various types of biological applications. This review outlines the recent advances in the structure and synthesis of PDA and discusses applications of PDA in many biological fields, such as biological imaging, photothermal therapy, and drug delivery systems...
June 11, 2018: Biomacromolecules
Hua Li, Feng Peng, Donghui Wang, Yuqin Qiao, Demin Xu, Xuanyong Liu
Magnesium (Mg) and its alloys are promising cardiovascular stent materials due to their favourable physical properties and complete degradation in vivo. However, rapid degradation and poor cytocompatibility hinder their clinical applications. To enhance the corrosion resistance and endothelialization of the AZ31 alloy, a layered double hydroxide (LDH)/poly-dopamine (PDA) composite coating (LDH/PDA) was successfully fabricated. Polarization curves and the electrochemical impedance spectroscopy Nyquist spectrum test proved that the corrosion resistance of the LDH/PDA sample was significantly improved in vitro...
June 25, 2018: Biomaterials Science
Dexian Kong, Qizhao Zhuang, Yejian Han, Lanping Xu, Zeming Wang, Lili Jiang, Jinwei Su, Chun-Hua Lu, Yuwu Chi
In the present study, procaterol hydrochloride (ProH) was successfully electropolymerized onto a glass carbon electrode (GCE) with simply cyclic voltammetry scans to construct a poly(procaterol hydrochloride) (p-ProH) membrane modified electrode. Compared with the bare GCE, much higher oxidation peak current responses and better peak potentials separation could be obtained for the simultaneous oxidation of dopamine (DA) and uric acid (UA), owning to the excellent electrocatalytic ability of the p-ProH membrane...
August 1, 2018: Talanta
Weiming Wu, Renliang Huang, Wei Qi, Rongxin Su, Zhimin He
Polyvinylidene fluoride (PVDF) membranes are limited in the field of oil-in-water emulsion treatment because the intrinsic hydrophobicity of PVDF can cause serious membrane fouling. Here, a superhydrophilic PVDF membrane (PVDF@PDA-GSH) was fabricated using a facile, versatile, mussel-inspired method. The pristine PVDF membrane was coated with dopamine under mild alkaline conditions by a dip-coating method, followed by addition of glutathione (GSH) via a simple reaction. GSH was successfully coated onto the membrane surface and confirmed by X-ray photoelectron spectroscopy and energy dispersive X-ray spectrometry...
June 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Rui Wu, Xiaokang Ding, Yu Qi, Qiang Zeng, Yu-Wei Wu, Bingran Yu, Fu-Jian Xu
One challenge for multimodal therapy is to develop appropriate multifunctional agents to meet the requirements of potential applications. Photodynamic therapy (PDT) is proven to be an effective way to treat cancers. Diverse polycations, such as ethylenediamine-functionalized poly(glycidyl methacrylate) (PGED) with plentiful primary amines, secondary amines, and hydroxyl groups, demonstrate good gene transfection performances. Herein, a series of multifunctional cationic nanoparticles (PRP) consisting of photosensitizer cores and PGED shells are readily developed through simple dopamine-involving processes for versatile bioapplications...
May 2018: Small
Jiaxing Sun, Jiefu Li, Dezhong Liu, Ying Ma, Shuguang Yang
Poly(acrylic acid) (PAA) was partially grafted with dopamine (PAA-dopa), and then layer-by-layer assembled with poly(vinylpyrrolidone) (PVPON) to prepare hydrogen-bonded (PVPON/PAA-dopa) n film. Polydopamine (PDA) was deposited on (PVPON/PAA-dopa) n film in the presence of oxidant, and hence the whole (PVPON/PAA-dopa) n PDA film was cross-linked. (PVPON/PAA-dopa) n PDA could be utilized as a platform to produce the free-standing Janus film because of the easy detaching process and various chemical reactivity of PDA layer...
June 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
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