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Living donor kidney

Min Li, Hua Zhou, Min Yang, Changying Xing
PURPOSE: Vascular calcification (VC) is known to be prevalent in patients with end-stage renal disease (ESRD). Sclerostin has been identified to be involved in the cross-talk between the kidney, vasculature, and bone. The aims of the present study were to evaluate vessel sclerostin expression and its correlation with VC, as well as serum sclerostin levels. METHODS: A total of 51 adult ESRD patients undergoing living donor renal transplant (RT) were enrolled in this study...
December 4, 2018: International Urology and Nephrology
Peter W Schreiber, Verena Kufner, Kerstin Hübel, Stefan Schmutz, Osvaldo Zagordi, Amandeep Kaur, Cornelia Bayard, Michael Greiner, Andrea Zbinden, Riccarda Capaul, Jürg Böni, Hans H Hirsch, Thomas F Mueller, Nicolas J Mueller, Alexandra Trkola, Michael Huber
Background: Before kidney transplantation, donors and recipients are routinely screened for viral pathogens using specific tests. Little is known about unrecognized viruses of the urinary tract that potentially result in transmission. Using an open metagenomic approach, we aimed to comprehensively assess virus transmission in living donor kidney transplantation. Methods: Living kidney donors and their corresponding recipients were enrolled at the time of transplantation...
December 2, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Rasha Kamal Abouelenein, Ayman Fathi Refaie, Yaser A Alhendy, Amir M Al Okily, Nabil Abdelfadil Elserwy, Mohamed Elsayed Mashaly, Mohamed Hamed Abbas, Mohamed Adel Bakr
OBJECTIVES: The goal when treating patients with end-stage renal disease is to increase patient survival and to provide a better quality of life, both of which can be achieved by kidney transplant. Identifying problems associated with kidney transplant is an essential step toward improved graft function. Here, we evaluated posttransplant erythrocytosis, a frequent complication among kidney transplant recipients. MATERIALS AND METHODS: In this single-center retro-spective study, we identified 1850 kidney transplant recipients who were transplanted at the Mansoura Urology and Nephrology Center (Mansoura University, Mansoura, Egypt) from 1990 and 2013...
November 28, 2018: Experimental and Clinical Transplantation
Steven Habbous, Justin Woo, Ngan N Lam, Krista L Lentine, Matthew Cooper, Marian Reich, Amit X Garg
Introduction: The process of evaluating candidates for living kidney donation can be inefficient. A structured review of existing information on this topic can provide a necessary foundation for quality improvement. Methods: We conducted a scoping review to map the published literature to different themes related to an efficient donor candidate evaluation. We reviewed the websites of living donor programs to describe information provided to candidates about the nature and length of the evaluation process...
October 2018: Transplantation Direct
Hyun Yong Lee, Young Nam Roh, Hyoung Tae Kim, Ui Jun Park
Late occurrence of arterial aneurysms following ligation of a hemodialysis arteriovenous fistula (AVF) is rare. Here, we report the case of 51-year-old male patient with an AVF in which arterial aneurysms developed. The patient had undergone left arm radiocephalic (RC) AVF creation for hemodialysis in 2000. He had received a living related donor kidney transplantation from his father in the same year. His RC AVF was ligated in 2009. However, his arm continued to gradually grow in size even after ligation and he visited a hospital for acute pain and erythema around the left elbow in 2017...
November 28, 2018: Vascular and Endovascular Surgery
Philip J Held, Frank McCormick, Glenn M Chertow, Thomas G Peters, John P Roberts
Government compensation of kidney donors would likely increase the supply of kidneys and prevent the premature deaths of tens of thousands of patients with kidney failure each year. The major argument against it is that it would exploit the poor who would be more likely to accept the offers of compensation. This overlooks the fact that many poor patients desperately need a kidney transplant and would greatly benefit from an increased supply of kidneys. The objective of this study is to empirically test the hypothesis that government compensation of kidney donors would exploit the poor...
2018: PloS One
Harold D Love, Mingfang Ao, Seiver Jorgensen, Lindsey Swearingen, Nicholas J Ferrell, Rachel C Evans, Leslie Gewin, Raymond C Harris, Roy Zent, Shuvo Roy, William H Fissell
End-stage renal disease afflicts nearly 750,000 Americans and claims over 100,000 lives annually in the United States. Kidney transplantation is associated with longest survival and least cost but is limited by scarcity of donor organs. Most patients are treated with hemodialysis. Each hemodialysis treatment consumes over 160 liters of water and anchors the patient to a machine for 12-15 hours per week. Cultured tubule cells can reduce the obligate fluid requirements of a bioengineered artificial kidney by concentrating wastes and reabsorbing filtered salt and water...
November 28, 2018: Tissue Engineering. Part A
Fahad Aziz, Sandesh Parajuli, Maha Mohamed, Neetika Garg, Brenda Muth, Didier Mandelbrot, Thomas Ellis, Weixiong Zhong, Arjang Djamali
BACKGROUND: Risk factors for graft loss in kidney transplant recipients with g3 lesions are poorly defined. MATERIALS AND METHODS: We evaluated outcomes in 37 consecutive kidney transplant biopsies diagnosed with g3 glomerulitis based on Banff 2013 criteria in a single-center observational study. RESULTS: The diagnosis of g3 glomerulonephritis was made 6.1 ± 6.6 years after transplant. The majority of patients were Caucasian (86%), male (65%), and received basiliximab induction (54%)...
November 26, 2018: Clinical Nephrology
Scott Davis, James Dylewski, Pratik B Shah, John Holmen, Zhiying You, Michel Chonchol, Jessica Kendrick
BACKGROUND: We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls. METHODS: Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery < 37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital > 3 days, infant death/transfer to acute facility and low birth weight (<2,500 gm)...
November 25, 2018: Clinical Transplantation
J Xu, L Xu, X Wei, X Li, M Cai
BACKGROUND: Posttransplantation diabetes mellitus (PTDM) is a frequent metabolic complication following solid organ transplantation and was proven to be associated with adverse outcome. This study aimed to identify the incidence and risk factors of PTDM under the background of relative-living renal transplantation in China. METHODS: We conducted a retrospective cohort study that included 358 recipients who underwent relative-living donor kidney transplantation in the Organ Transplant Institute of 309th Hospital of People's Liberation Army between January 1, 2010, and December 31, 2014...
August 9, 2018: Transplantation Proceedings
M S Chae, Y Kim, S A Oh, Y Jeon, H J Choi, Y H Kim, S H Hong, C S Park, J Huh
BACKGROUND: Combined liver and kidney transplant is a very complex surgery. To date, there has been no report on the intraoperative management of patients with impaired cardiac function undergoing simultaneous ABO-compatible liver and ABO-incompatible kidney transplant from 2 living donors. CASE REPORT: A 60-year-old man underwent simultaneous ABO-compatible liver and ABO-incompatible kidney transplant from 2 living donors because of IgA nephropathy and alcoholic liver cirrhosis...
September 7, 2018: Transplantation Proceedings
Christine S Hwang, Malcolm Macconmara, Dev M Desai
Pediatric liver and kidney transplantation have become the standard and accepted treatment for children with end-stage renal and liver disease. Since the first successful kidney transplant in 1954 by Dr Joseph Murray and the first liver transplant by Dr Thomas Starzl, the scope of indications for visceral organ transplantation as well as the range of recipient and donor ages has expanded. The first pediatric liver and kidney transplants, simultaneous multivisceral transplants, living-donor and donation-after-cardiac-death organs have evolved rapidly into the standard of care for end-stage renal and liver failure in children...
February 2019: Surgical Clinics of North America
Lung-Yi Lee, Thomas A Pham, Marc L Melcher
End-stage renal disease (ESRD) is a significant health care burden. Although kidney transplantation is the optimal treatment modality, less than 25% of waiting list patients are transplanted because of organ shortage. Living kidney donation can lead to better recipient and graft survival and increase the number of donors. Not all ESRD patients have potential living donors, and not all living donors are a compatible match to recipients. Kidney paired exchanges allow incompatible pairs to identify compatible living donors for living donor kidney transplants for multiple recipients...
February 2019: Surgical Clinics of North America
Giovanni Gambaro, G Zaza, F Citterio, A Naticchia, P M Ferraro
Deciding whether to accept a donor with nephrolithiasis is a multifaceted task because of the challenge of finding enough suitable donors while at the same time ensuring the safety of both donors and recipients. Until not long ago, donors with a history of renal stones or with stones emerging during screening on imaging were not considered ideal, but recent guidelines have adopted less stringent criteria for potential donors at risk of stones. This review goes through the problems that need to be approached to arrive at a wise clinical decision, balancing the safety of donors and recipients with the need to expand the organ pool...
November 23, 2018: Urolithiasis
Anthony Fenton, Emma Montgomery, Peter Nightingale, A Michael Peters, Neil Sheerin, A Caroline Wroe, Graham W Lipkin
BACKGROUND: There is a need for a large, contemporary, multi-centre series of measured glomerular filtration rates (mGFR) from healthy individuals to determine age- and gender-specific reference ranges for GFR. We aimed to address this and to use the ranges to provide age- and gender-specific advisory GFR thresholds considered acceptable for living kidney donation. METHODS: Individual-level data including pre-donation mGFR from 2974 prospective living kidney donors from 18 UK renal centres performed between 2003 and 2015 were amalgamated...
November 22, 2018: BMC Nephrology
Gregory Xiang Wen Pek, Clara Lee Ying Ngoh, Boon Wee Teo, Anantharaman Vathsala, Benjamin Yen Seow Goh, Clement Hsiang Rong Yong, Lata Raman, Ho Yee Tiong
INTRODUCTION: Obesity may be a risk factor for kidney donors to develop reduced renal function. The Framingham heart study suggested that visceral adipose tissue (VAT) confers a more adverse metabolic profile compared with subcutaneous adipose tissue (SAT). Asians tend to have a higher VAT composition and it is unclear if their kidney function is affected differently. We hypothesized that Asian living kidney donors who have visceral obesity are at a higher risk of renal function deterioration 1 year after donation...
November 19, 2018: World Journal of Urology
F G Menezes, L Corrêa, J O Medina-Pestana, W F Aguiar, L F A Camargo
BACKGROUND: Urinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose of this study was to compare the efficacy of Nitrofurazone-coated silicone urinary catheters with non-impregnated silicone urinary catheters in reducing bacteriuria and urinary tract infections in kidney transplant recipients. METHODS: This single-center study, randomized controlled trial at the Hospital do Rim, a tertiary referral center in kidney transplantation, located in São Paulo, Brazil...
November 19, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Péter Biró, Ádám Remport, Sándor Mihály, Lóránt Illésy, Balázs Nemes
Patients with end-stage renal disease may exchange their willing, but incompatible donors among each other in centrally coordinated kidney exchange programmes. The aim of this writing is to summarise the results of the ENCKEP COST Action, and describe the lessons learned with regard to the plans for the Hungarian kidney exchange programme. The ENCKEP COST Action had several workshops since 2016 September, and its first working group conducted two surveys that they summarised in two handbooks; our description is based on these resources...
November 2018: Orvosi Hetilap
László Wagner, István Wittmann, László Piros, Réka P Szabó, Péter Szakály
Diabetes increases the risk of different kidney diseases. The most important is diabetic nephropathy, however, ischemic kidney disease, chronic pyleonephritis and papilla necrosis may also develop. The prognosis of diabetic nephropathy has improved recently, however, it is still the primary cause of dialysis and transplantation. Cardiovascular diseases predict mostly mortality in diabetic patients, however, cerebrovascular insults and peripheral obstructive arterial diseases necessitating lower limb amputations are also important...
November 2018: Orvosi Hetilap
Luan D Truong, Lillian W Gaber, Faiza Khan
Knowledge on renal involvement in kidney donors with diabetes i.e., diabetic nephropathy (DN), is limited. During the 7years (2010-2017), 921 post-perfusion biopsies were performed for living donors (14%) or deceased donors (86%). The Renal Pathology Society Classification schema for DN (Class 0-IV) was used. Biopsies with light microscopic changes of DN (at least Class IIa) were selected for study. Eleven biopsies (1.2%) showed DN, all from deceased donors (Class IIa in 8, Class IIb in 2, and Class III in 1 biopsy)...
November 15, 2018: Human Pathology
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