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Living donor kidney

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https://www.readbyqxmd.com/read/30336216/pretransplant-angiotensin-ii-type-1-receptor-antibodies-point-to-an-increase-in-renal-graft-sub-intimal-fibrosis-in-living-donor-kidney-transplant-recipients
#1
Alberto González-Almada, José M Arreola-Guerra, José Argenis López-Sánchez, Eric Cuevas, Mario Vilatoba, Alan G Contreras, Luis E Morales-Buenrostro, Josefina Alberu, Norma O Uribe-Uribe
The association between anti-AT1Rabs and microvascular injury observed in antibody-mediated rejection has been described in kidney graft Biopsies (KGBx). METHODS: We herein describe the histopathologic findings of KGBx performed during the first year of transplantation (Tx) in 134 patients tested for pre-Tx anti-AT1Rabs in cryopreserved sera (04/2009 to 09/2013). Protocol KGBx before implantation (time-zero), 1 year after Tx and for cause KGBx were included. 21/134 Tx patients were anti-AT1Rab positive (≥17 U/mL); 7/21 experienced acute rejection...
October 15, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/30335693/informative-for-decision-making-the-spectrum-and-consistency-of-outcomes-following-living-kidney-donation-reported-in-trials-and-observational-studies
#2
Camilla S Hanson, Benedicte Sautenet, Jonathan C Craig, Jeremy R Chapsman, Greg Knoll, Peter P Reese, Allison Tong
BACKGROUND: Evidence about outcomes following living kidney donation is needed both to inform donor acceptance criteria, and to guide the decisions of potential donors and their healthcare providers about donation. However, the scope and heterogeneity of outcomes reported in research and their relevance to decision-making is uncertain. To determine the spectrum and consistency of outcomes reported in randomized trials and observational studies in living kidney donors aged 18 years or over...
October 17, 2018: Transplantation
https://www.readbyqxmd.com/read/30334486/-the-first-five-years-of-hungary-s-eurotransplant-membership
#3
Róbert Langer
The author concludes lessons learned from Hungary joining Eurotransplant five years ago through the more than half a century history of the Hungarian organ transplantation. The result of the stepwise evolution is that today's transplantation activity can be measured by a European benchmark. In comparison to the era before the membership, there are 40% more transplantations in the country. First the numbers of the living donor kidney transplantations significantly raised, followed by the organs transplanted from brain-dead donors: kidney, heart, pancreas, then liver and finally also lung...
October 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30328079/sarcoidosis-in-the-renal-allograft-of-a-recipient-whose-primary-disease-was-autosomal-dominant-polycystic-kidney-disease
#4
Takahiro Shinzato, Taro Kubo, Toshihiro Shimizu, Koji Nanmoku, Takashi Yagisawa
We report a 55-year-old man with a renal allograft that developed sarcoidosis. His autosomal dominant polycystic kidney disease (ADPKD) progressed to end-stage stage renal disease when he was 52 years old, and he underwent living-donor kidney transplantation at the age of 53 years. His proteinuria worsened at 19 months post-transplantation, and his renal function began to decline at 29 months post-transplantation. A renal allograft biopsy performed at 31 months post-transplantation revealed non-caseating granulomatous interstitial nephritis...
October 16, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/30326148/diabetic-nephropathy-after-kidney-transplantation-in-patients-with-pre-transplantation-type-ii-diabetes-a-retrospective-case-series-study-from-a-high-volume-center-in-the-united-states
#5
Arielle Cimeno, Jennifer Munley, Cinthia Drachenberg, Matthew Weir, Abdolreza Haririan, Jonathan Bromberg, Rolf N Barth, Joseph R Scalea
BACKGROUND: Patients with type II diabetes mellitus (DM) undergoing renal transplantation are at risk of diabetic nephropathy (DN) in the transplanted kidney. The true risk of developing post-transplantation DN is unknown, and post-transplantation DN is poorly characterized in the literature. METHODS: The biopsy database at the University of Maryland Medical Center was queried for kidney transplant biopsies which demonstrated evidence of DN. The time from transplantation to biopsy-proven DN (time to diagnosis, TTD) was calculated and analyzed in the context of demographics, serum creatinine, and onset of diabetes...
October 16, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30324973/nephrolithiasis-in-living-kidney-donor-experience-of-nephrologists
#6
Hayet Kaaroud, Amel Harzallah, Mariem Najjar, Nour Houda Chtioui, Mohamed Cherif, Haroun Ayed, W Kerkeni, A Bouzouita, M Chebil, Emna Talbi, Hanene Baccouch, Amal Benzarti, Jaouida Abdelmoula, Fethi Benhamida, Taieb Ben Abdallah
BACKGROUND: Living kidney donation for transplantation has become common practice. The decisions to accept a donor with nephrolithiasis are becoming frequent. AIM: The aim of our study was to report our experience in the living donor kidney with asymptomatic lithiasis. METHODS: Over a period of 4 years from 2009 to 2013 we collected 18 cases. From the clinical, metabolic and radiological data, we have determined the etiology of urolithiasis in our patients and established, after a literature review, a decision tree of kidney donation...
February 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30322745/immunogenicity-and-efficacy-of-the-monovalent-trivalent-and-quadrivalent-intranasal-live-attenuated-influenza-vaccines-containing-different-pdmh1n1-strains
#7
Leena R Yeolekar, Milan Ganguly, Parikshit Tyagi, Nilesh B Ingle, Koert J Stittelaar, Leon de Waal, Francesco Berlanda Scorza, Kutub Mahmood, Rajeev M Dhere
A ferret challenge study was conducted to address the efficacy of the egg-based and Madin-Darby canine kidney (MDCK)-based live attenuated influenza vaccine (LAIV) strains. Vaccines derived as 6:2 reassortants from the A/Leningrad/134/17/57 master donor strain and the HA and NA components from the A/California/07/2009 (A/Cal)- and A/Michigan/45/2015 (A/Mich)-like strains of type A H1N1 influenza virus were used in the study. Monovalent, trivalent and quadrivalent formulations of the LAIV containing either of the two H1N1 strains were analysed...
October 12, 2018: Vaccine
https://www.readbyqxmd.com/read/30317187/living-donor-renal-transplant-in-a-patient-with-end-stage-renal-disease-due-to-hermansky-pudlak-syndrome
#8
Nassreen Abdullah, Niall F Davis, John Quinn, Ponnusamy Mohan
Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder characterised by oculocutaneous albinism, bleeding diathesis and end-stage renal disease (ESRD), due to interstitial deposition of ceroid lipofuscin. Renal transplantation is potentially a definitive treatment option for patients with ESRD due to HPS. Herein, we describe the case of a 55-year-old male patient with HPS that successfully underwent a living donor kidney transplant. We also emphasise the importance of multidisciplinary input during the preoperative, perioperative and postoperative phases in this high-risk clinical scenario...
October 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30316403/living-kidney-donor-with-small-lymphocytic-lymphoma-at-the-time-of-donation-a-case-report
#9
S Tatarano, H Enokida, Y Yamada, H Nishimura, M Nakagawa
Living kidney donor guidelines recommend that donors in whom a malignancy is diagnosed should be excluded. Although preoperative screening for malignancies was performed, we experienced a case of living donor with small lymphocytic lymphoma (SLL) at the time of donation. A 53-year-old woman was referred to our hospital for a kidney donation to her son. She had no past medical history of malignancy. We screened the patient using medical examinations, but there was no obvious presence of malignancy. Although preoperative computed tomography showed a small lymph node swelling at the left renal hilum, we diagnosed it as an insignificant lymph node...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316400/safety-of-elderly-living-kidney-donors-2-cases-of-donors-older-than-80-years-a-case-report
#10
H Hirano, R Maenosono, T Matsunaga, H Uehara, H Nomi, A Ichihashi, D Kobayashi, S Taniguchi, T Tsutsumi, T Tsujino, K Komura, N Ibuki, T Inamoto, H Azuma
Much controversy exists over the performance of elderly living donor kidney transplantation. We report the safety of 2 cases of elderly living kidney donations in our hospital. CASE 1: An 82-year-old man was a living kidney donor for his 56-year-old son. The donor suffered from hypertension, but has successfully managed his blood pressure with only one medication. His serum creatinine was 0.7 mg/dL and inulin clearance was 122.5 mL/min, which met the usual criteria for living kidney donors. This was his son's secondary kidney transplantation, and no other donors existed...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316399/recurrent-membranous-nephropathy-after-kidney-transplantation-associated-with-phospholipase-a2-receptor-and-successfully-treated-with-rituximab-a-case-report
#11
A Ishiwatari, S Wakai, H Shirakawa, K Honda
Primary membranous nephropathy (MN) is an organ-specific autoimmune disease mainly caused by autoantibodies acting against the podocyte antigen M-type phospholipase A2 receptor 1 (PLA2R). Herein we present the clinical and histologic findings, including PLA2R staining, of early recurrent MN after kidney transplantation that was successfully treated with rituximab. A 60-year-old Japanese man had end-stage renal failure due to steroid-resistant primary MN and underwent ABO-incompatible living donor kidney transplantation...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316396/acute-antibody-mediated-rejection-by-de-novo-anti-hla-dp%C3%AE-and-dp%C3%AE-antibodies-after-kidney-transplantation-a-case-report
#12
D Thammanichanond, W Parapiboon, T Mongkolsuk, S Worawichawong, C Tammakorn, P Kitpoka
The presence of isolated de novo anti-DP antibodies is uncommon, making it difficult to determine the impact of anti-DP antibodies on graft outcome. We describe a case of acute antibody-mediated rejection mediated by de novo donor-specific anti-HLA-DP antibodies. Furthermore, the generation of non-donor-specific anti-DP antibodies (NDSAs) detected in the patient's sera was investigated. An 18-year-old woman with pretransplant 0% panel-reactive antibody received kidney transplantation from a living donor. She experienced combined acute T-cell-mediated and antibody-mediated rejection at 15 months after transplantation...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316394/radical-prostatectomy-for-localized-prostate-cancer-in-renal-transplant-recipients-13-cases-studied-at-a-single-center
#13
K Iwamoto, J Iizuka, Y Hashimoto, T Kondo, T Takagi, K Hata, K Unagami, M Okumi, H Ishida, K Tanabe
OBJECTIVES: We aimed to evaluate the feasibility and efficacy of surgical prostatectomy in renal transplant recipients (RTRs). METHODS: Between January 2008 and February 2017, we identified 13 RTRs who were diagnosed with localized prostate cancer and underwent radical prostatectomy. We reviewed all available clinicopathologic data for these 13 patients. RESULTS: The median patient age was 61 years and median serum prostate-specific antigen (PSA) was 8...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316384/spectrum-of-infections-in-living-donor-kidney-transplant-recipients-an-experience-from-a-tertiary-center-in-nepal
#14
M P Kafle, M R Sigdel, M Shrestha, D S Shah
BACKGROUND: Kidney transplant recipients are always at risk of infections because they are on lifelong immunosuppressive medications. The spectrum of infections in this special population is not the same as in the general population. Post-transplant infections are extensively studied in the developed world. Publications about post-transplant infections from Nepal are scarce. This study was carried out to study the spectrum of infections, the trends in treatment, and the incidence of tuberculosis in kidney transplant recipients...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316378/early-outcomes-of-living-donor-kidney-transplantation-with-immunosuppression-therapy-induction-with-tacrolimus-extended-release-a-comparison-with-cyclosporine
#15
O Konno, T Yokoyama, Y Kihara, Y Nakamura, T Ueno, H Takeuchi, H Iwamoto
BACKGROUND: Extended-release tacrolimus (TacER), administered once daily, offers improved adherence with reduced side effects while still maintaining an immunosuppressive potency equivalent to that of conventional tacrolimus preparations. METHODS: The study included 83 patients who received consecutive living-donor kidney transplants at our facility from June 2013 to December 2016. Comparisons were made between 48 cases of induction with TacER and 35 cases of induction with cyclosporine (CyA)...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316372/effect-of-donor-age-on-graft-function-and-pathologic-findings-in-living-donor-transplantation
#16
S Sekito, K Nishikawa, S Masui, Y Hasegawa, H Kanda, K Arima, Y Sugimura
BACKGROUND: The frequency of renal transplants from elderly living donors has increased because of a shortage of donors. However, the results of renal transplantation using aged kidney grafts have yet to be determined conclusively. METHODS: We evaluated 45 patients who underwent living donor kidney transplantation at our institution. The patients were categorized according to donor age at the time of the transplant: ≥ 60 years (elderly donor group, n = 21) and <60 years (young donor group, n = 24)...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316370/higher-incidence-of-renal-allograft-glomerulonephritis-in-living-related-donor-kidney-transplantation
#17
R Deng, Y Dai, H Zhang, L Liu, J Li, Y Xiong, S Deng, Q Fu, C Wang
Glomerulonephritis recurrence has emerged as one of the leading causes of allograft loss. We aimed to investigate the effect of living-related and deceased donation on the incidence of renal allograft glomerulonephritis and its effect on renal allograft survival. METHODS: Adult renal allograft recipients with primary glomerulonephritis were enrolled. Transplantation date was from Feb 2004 to Dec 2015. Exclusion criteria included combined organ transplantation, structural abnormality, diabetic nephropathy, hypertension nephropathy, obstructive nephropathy, and primary uric acid nephropathy...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316369/different-risk-factors-for-graft-survival-between-living-related-and-deceased-donor-kidney-transplantation
#18
H Zhang, Y Wei, L Liu, J Li, R Deng, Y Xiong, X Yuan, X He, Q Fu, C Wang
The aim of this study was to determine distinctive risk factors for graft survival of living-related and deceased donor kidney transplantation (KTx). METHODS: Consecutive 536 living-related and 524 deceased donor kidney transplant recipients from February 2014 to December 2015 in a single center were enrolled for retrospective analysis. Graft survival was assessed with the Kaplan-Meier method, and the Cox proportional hazard model was used to determine independent risk factors of allograft survival...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316368/higher-renal-allograft-function-in-deceased-donor-kidney-transplantation-rather-than-in-living-related-kidney-transplantation
#19
Y Xiong, J Jiang, H Zhang, Q Fu, R Deng, J Li, L Liu, X Yuan, X He, C Wang
OBJECTIVES: To compare the clinical outcome of kidney transplantation from living-related and deceased donors. PATIENTS AND METHODS: Consecutive adult kidney transplants from living-related or deceased donors from February 2004 to December 2015 in a single center were enrolled for retrospective analysis. Estimated glomerular filtration rate (eGFR) was compared with linear mixed models controlling the effect of repeated measurement at different time points. RESULTS: There were 536 living-related and 524 deceased donor kidney transplants enrolled...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30316355/follow-up-status-of-living-kidney-donors-after-transplantation
#20
M K Ju, S Son, S Kim
BACKGROUND: The purpose of this study was to identify the follow-up status of living kidney donors after transplantation. METHODS: This study was a secondary analysis of the medical record data from one hospital in Korea. Eighty-one donors from February 2010 to April 2016 were selected for analysis of follow-up status. Data were analyzed using descriptive statistics, Kaplan-Meier estimator, and Cox regression. RESULTS: Overall, 48.4% of donors continued to participate in follow-up visits...
October 2018: Transplantation Proceedings
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