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https://www.readbyqxmd.com/read/29984108/visualization-of-drug-distribution-of-a-topical-minocycline-gel-in-human-facial-skin
#1
Sinyoung Jeong, Maiko Hermsmeier, Sam Osseiran, Akira Yamamoto, Usha Nagavarapu, Kin F Chan, Conor L Evans
Acne vulgaris is a common chronic skin disease in young adults caused by infection of the pilosebaceous unit, resulting in pimples and possibly permanent scarring on the skin. Minocycline, a common antibiotic, has been widely utilized as a systemic antimicrobial treatment for acne via oral administration. Recently, a topical minocycline gel (BPX-01) was developed to directly deliver minocycline through the epidermis and into the pilosebaceous unit to achieve localized treatment with lower doses of drug. As the effectiveness of the drug is directly related to its successful delivery, there is a need to evaluate the pharmacokinetics at the cellular level within tissue...
July 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29799951/association-of-depressive-symptoms-and-heart-rate-variability-in-vietnam-war-era-twins-a-longitudinal-twin-difference-study
#2
Minxuan Huang, Amit Shah, Shaoyong Su, Jack Goldberg, Rachel J Lampert, Oleksiy M Levantsevych, Lucy Shallenberger, Pratik Pimple, J Douglas Bremner, Viola Vaccarino
Importance: Depressive symptoms are associated with lower heart rate variability (HRV), an index of autonomic dysregulation, but the direction of the association remains unclear. Objective: To investigate the temporal association between depression and HRV. Design, Settings, and Participants: A longitudinal, cross-lagged twin difference study, with baseline assessments from March 2002 to March 2006 (visit 1) and a 7-year follow-up (visit 2) at an academic research center with participants recruited from a national twin registry...
July 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29744960/tepid-massage-for-febrile-children-a-systematic-review-and-meta-analysis
#3
Junghee Lim, Juyoung Kim, Bora Moon, Gaeun Kim
AIM: This study aimed to examine the effect of tepid massage in febrile children comparing with other fever management. METHODS: Experimental studies published in English were included; quasi-experimental research studies were also included in consideration of rare experimental studies in Korean. The search strategy sought to identify published research reports in the English language and covered all major databases up to 2016. The methodological quality of each study was assessed by 2 independent reviewers using a Scottish Intercollegiate Guidelines Network's Methodology Checklist...
May 10, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29743339/compliance-with-point-of-sale-tobacco-control-policies-and-student-tobacco-use-in-mumbai-india
#4
Ritesh Mistry, Mangesh S Pednekar, William J McCarthy, Ken Resnicow, Sharmila A Pimple, Hsing-Fang Hsieh, Gauravi A Mishra, Prakash C Gupta
BACKGROUND: We measured how student tobacco use and psychological risk factors (intention to use and perceived ease of access to tobacco products) were associated with tobacco vendor compliance with India's Cigarettes and Other Tobacco Products Act provisions regulating the point-of-sale (POS) environment. METHODS: We conducted a population-based cross-sectional survey of high school students (n=1373) and tobacco vendors (n=436) in school-adjacent communities (n=26) in Mumbai, India...
May 9, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29578097/are-two-doses-of-human-papillomavirus-vaccine-sufficient-for-girls-aged-15-18-years-results-from-a-cohort-study-in-india
#5
Neerja Bhatla, Bhagwan M Nene, Smita Joshi, Pulikottil O Esmy, Usha Rani Reddy Poli, Geeta Joshi, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Priya R Prabhu, Partha Basu, Richard Muwonge, Sanjay Hingmire, Catherine Sauvaget, Eric Lucas, Michael Pawlita, Tarik Gheit, Kasturi Jayant, Sylla G Malvi, Maqsood Siddiqi, Angelika Michel, Julia Butt, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Martina Willhauck-Fleckenstein, Tim Waterboer, Martin Müller, Peter Sehr, Alka Kriplani, Gauravi Mishra, Radhika Jadhav, Ranjit Thorat, Massimo Tommasino, M Radhakrishna Pillai, Rengaswamy Sankaranarayanan
Extending two-dose recommendations of HPV vaccine to girls between 15 and 18 years will reduce program cost and improve compliance. Immunogenicity and vaccine targeted HPV infection outcomes were compared between 1795 girls aged 15-18 years receiving two (1-180 days) and 1515 girls of same age receiving three (1-60-180 days) doses. Immunogenicity outcomes in 15-18 year old two-dose recipients were also compared with the 10-14 year old three-dose (N = 2833) and two-dose (N = 3184) recipients. The 15-18 year old two-dose recipients had non-inferior L1-binding antibody titres at seven months against vaccine-targeted HPV types compared to three-dose recipients at 15-18 years and three-dose recipients at 10-14 years of age...
June 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29559599/-effect-of-ozone-on-staphylococcus-aureus-colonization-in-patients-with-atopic-dermatitis
#6
Jianyun Lu, Miaomiao Li, Jian Huang, Lihua Gao, Yizhi Pan, Zhibing Fu, Jianhua Dou, Jinhua Huang, Yaping Xiang
To verify the effect of ozone on Staphylococcus aureus (S. aureus) colonization in patients with atopic dermatitis (AD) and its correlation with the patient's status.
 Methods: A total of 12 patients with moderate or severe AD, aged from 6 to 65 years, were recruited from outpatient of the Third Xiangya Hospital. The treatment sides were showered with ozonated water and smeared with ozonated oil for 7 days (twice a day), while the control sides were washed with warm running water and smeared with base oil...
February 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29552276/quality-of-life-in-individuals-with-erythematotelangiectatic-and-papulopustular-rosacea-findings-from-a-web-based-survey
#7
Joshua A Zeichner, Lawrence F Eichenfield, Steven R Feldman, J Scott Kasteler, Ilia L Ferrusi
OBJECTIVE: The objective of the study was to evaluate the impact of rosacea on self-perception, emotional, social, and overall well-being and quality of life in individuals with erythematotelangiectatic rosacea (ETR) and papulopustular rosacea (PPR). DESIGN: We distributed a cross-sectional email invitation for participants in the United States to fill out a web-based survey. PARTICIPANTS: We included adults who reported having previously received a diagnosis of erythematotelangiectatic rosacea or papulopustular rosacea...
February 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29551226/can-a-single-dose-of-human-papillomavirus-hpv-vaccine-prevent-cervical-cancer-early-findings-from-an-indian-study
#8
Rengaswamy Sankaranarayanan, Smita Joshi, Richard Muwonge, Pulikottil Okkuru Esmy, Partha Basu, Priya Prabhu, Neerja Bhatla, Bhagwan M Nene, Janmesh Shaw, Usha Rani Reddy Poli, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Massimo Tommasino, Michael Pawlita, Tarik Gheit, Tim Waterboer, Peter Sehr, Madhavan Radhakrishna Pillai
BACKGROUND: Human papillomavirus (HPV) vaccination is a major strategy for preventing cervical and other ano-genital cancers. Worldwide HPV vaccination introduction and coverage will be facilitated if a single dose of vaccine is as effective as two or three doses or demonstrates significant protective effect compared to 'no vaccination'. METHODS: In a multi-centre cluster randomized trial of two vs three doses of quadrivalent HPV vaccination (Gardasil™) in India, suspension of the vaccination due to events unrelated to the study led to per protocol and partial vaccination of unmarried 10-18 year old girls leading to four study groups, two by design and two by default...
August 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29459465/mental-stress-induced-myocardial-ischemia-in-young-patients-with-recent-myocardial-infarction-sex-differences-and-mechanisms
#9
Viola Vaccarino, Samaah Sullivan, Muhammad Hammadah, Kobina Wilmot, Ibhar Al Mheid, Ronnie Ramadan, Lisa Elon, Pratik M Pimple, Ernest V Garcia, Jonathon Nye, Amit J Shah, Ayman Alkhoder, Oleksiy Levantsevych, Hawkins Gay, Malik Obideen, Minxuan Huang, Tené T Lewis, J Douglas Bremner, Arshed A Quyyumi, Paolo Raggi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and is associated with worse prognosis. Young women with a previous myocardial infarction (MI), a group with unexplained higher mortality than men of comparable age, have shown elevated rates of MSIMI, but the mechanisms are unknown. METHODS: We studied 306 patients (150 women and 156 men) ≤61 years of age who were hospitalized for MI in the previous 8 months and 112 community controls (58 women and 54 men) frequency matched for sex and age to the patients with MI...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29440794/an-innovative-and-less-invasive-management-of-recurrent-pyogenic-granuloma-in-the-esthetic-zone-a-case-report-with-18-month-follow-up
#10
Superna Tiwari, Abhilash Neelakanti, Sunil Sathyanarayana
Pyogenic granuloma (PG) is a nonneoplastic, tumor-like growth commonly seen in the oral mucosa or skin. Although nonpathological, its existence might lead to complications such as secondary infections or diastema formation. Hence, surgical removal of the growth seems mandatory. Histopathologic and radiographic evaluation is essential for accurate diagnosis and to rule out malignancy. A 28-year-old systemically healthy female patient reported with a swelling which involved the interdental space of maxillary left central and lateral incisors...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29440677/nanobody-triggered-lockdown-of-vsrs-reveals-ligand-reloading-in-the-golgi
#11
Simone Früholz, Florian Fäßler, Üner Kolukisaoglu, Peter Pimpl
Protein degradation in lytic compartments is crucial for eukaryotic cells. At the heart of this process, vacuolar sorting receptors (VSRs) bind soluble hydrolases in the secretory pathway and release them into the vacuolar route. Sorting efficiency is suggested to result from receptor recycling. However, how and to where plant VSRs recycle remains controversial. Here we present a nanobody-epitope interaction-based protein labeling and tracking approach to dissect their anterograde and retrograde transport routes in vivo...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29366811/plant-membrane-trafficking-is-coming-of-age
#12
EDITORIAL
Gerd Jürgens, Peter Pimpl
No abstract text is available yet for this article.
August 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29332110/association-of-psychological-stress-with-skin-symptoms-among-medical-students
#13
Ghada A Bin Saif, Hala M Alotaibi, Abdullateef A Alzolibani, Noor A Almodihesh, Hamad F Albraidi, Najed M Alotaibi, Gil Yosipovitch
To evaluate the association between psychological stress and skin symptoms among medical students.  Methods: A cross-sectional study was carried out between January and June 2015. Electronic survey consists of Perceived Stress Questionnaire (PSQ) and Self-Reported Skin Complaints Questionnaire were distributed to all 1435 undergraduate students at College of Medicine, King Saud University (KSU), Riyadh, Saudi Arabia. Results: Final analysis was performed on data from 529 (36.9%) students. Students were divided into three groups: least stressed students, n=135, PSQ index less than 0...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29259360/influence-of-root-canal-obturation-using-gutta-percha-with-three-different-sealers-on-root-reinforcement-of-endodontically-treated-teeth-an-in-vitro-comparative-study-of-mandibular-incisors
#14
Pravin Patil, Kulwinder Singh Banga, Ajinkya M Pawar, Sandeep Pimple, Raguram Ganeshan
Aim: The purpose of this in vitro study was to evaluate the vertical force required to fracture mandibular incisor teeth, obturated using gutta-percha with three different sealers. Materials and Methods: Seventy-five extracted mandibular incisors with intact and fully formed apices, exhibiting single root and canal were acquired. The teeth were decoronated obtaining a root segments of 15 mm and were divided into five groups ( n = 15). Group 1: left uninstrumented and unfilled (negative control)...
July 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29224740/chest-pain-and-mental-stress-induced-myocardial-ischemia-sex-differences
#15
Pratik Pimple, Muhammad Hammadah, Kobina Wilmot, Ronnie Ramadan, Ibhar Al Mheid, Oleksiy Levantsevych, Samaah Sullivan, Ernest V Garcia, Jonathon Nye, Amit J Shah, Laura Ward, Puja Mehta, Paolo Raggi, J Douglas Bremner, Arshed A Quyyumi, Viola Vaccarino
BACKGROUND: Mental stress-induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease. Women with coronary artery disease tend to have more mental stress-induced myocardial ischemia and more chest pain/anginal symptoms than men, but whether the association between mental stress-induced myocardial ischemia and angina burden differs in women and men is unknown. METHODS: This was a cross-sectional study with experimental manipulation of 950 individuals with stable coronary artery disease...
May 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29023067/studies-on-staphylococcus-aureus-isolated-from-pimples
#16
Ajayi Adesola Adetutu, Bibi Oritsewehinmi, Oniha Margaret Ikhiwili, Atolagbe Oluwabunmi Moradeke, Anosike Selina Odochi, Onibokun Elizabeth Adeola
BACKGROUND AND OBJECTIVE: Pimples (acne) are small skin lesions or inflammations of the skin. The most common factor causing acne is the hormonal changes that occur during adolescent and teenage years. Antibiotics are becoming less effective in the treatment of pimples due to increasing concerns of antibiotic resistance. This study was therefore carried out to characterize the isolates from the pimples of Covenant University Students and to determine their antibiotics sensitivity pattern...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28986223/inflammatory-response-to-mental-stress-and-mental-stress-induced-myocardial-ischemia
#17
Muhammad Hammadah, Samaah Sullivan, Brad Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T O'Neal, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Heval Mohamed Kelli, Mohamad Mazen Ghafeer, Pratik Pimple, Pratik Sandesara, Amit J Shah, Kareem Mohammed Hosny, Laura Ward, Yi-An Ko, Yan V Sun, Lei Weng, Michael Kutner, J Douglas Bremner, David S Sheps, Fabio Esteves, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia. METHODS: Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor...
February 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28979654/the-burden-of-illness-of-erythematotelangiectatic-rosacea-and-papulopustular-rosacea-findings-from-a-web-based-survey
#18
James Q Del Rosso, Emil A Tanghetti, Hilary E Baldwin, David A Rodriguez, Ilia L Ferrusi
Objective: Evaluate patients' perceptions of rosacea symptoms and treatments. Design: Cross-sectional, web-based survey conducted from May 8 to July 1,2015. Setting: E-mail invitation. Participants: Male and female adults in the United States who self-reported having a physician's diagnosis of rosacea. Measurements: Sociodemographic and clinical characteristics were collected for eligible respondents using the Self-Assessment of Rosacea Facial Redness scale and the Symptom Assessment for Rosacea Facial Bumps and Pimples questionnaire...
June 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28938773/characteristics-of-global-organic-matrix-in-normal-and-pimpled-chicken-eggshells
#19
Z Liu, L Song, F Zhang, W He, R J Linhardt
The organic matrix from normal and pimpled calcified chicken eggshells were dissociated into acid-insoluble, water-insoluble, and facultative-soluble (both acid- and water-soluble) components, to understand the influence of shell matrix on eggshell qualities. A linear correlation was shown among these 3 matrix components in normal eggshells but was not observed in pimpled eggshells. In pimpled eggshells, the percentage contents of all 4 groups of matrix (the total matrix, acid-insoluble matrix, water-insoluble matrix, and facultative-soluble matrix) were significantly higher than that in normal eggshells...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28910196/effect-of-alpinia-galanga-on-mental-alertness-and-sustained-attention-with-or-without-caffeine-a-randomized-placebo-controlled-study
#20
RANDOMIZED CONTROLLED TRIAL
Shalini Srivastava, Mark Mennemeier, Surekha Pimple
OBJECTIVE: Although Alpinia galanga has been reported to improve cognitive performance in animals, it has not been thoroughly studied for its potential psychostimulant effect in humans. A randomized, double-dummy, double-blind, placebo-controlled cross-over study was conducted to determine the effect of A galanga on mental alertness and sustained attention in comparison with caffeine and placebo in participants with a habitual caffeine intake. METHODS: Fifty-nine participants (18-40 years and body mass index of ≥18...
November 2017: Journal of the American College of Nutrition
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