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catenin hepatocellular carcinoma

Zhusheng Yin, Wei Xu, Hao Xu, Junnian Zheng, Yuming Gu
Histone deacetylase 6 (HDAC6), a specific histone deacetylase family member, serves an essential role in the regulation of gene expression, cell cycle progression, autophagy and apoptosis. There are numerous reports on the function of HDAC6 in cancer. However, the specific function of HDAC6 in hepatocellular carcinoma (HCC) has yet to be revealed. In the present study, the expression of HDAC6 was revealed to be downregulated in human HCC cell lines and tissues. The aberrant activation of the canonical Wnt/β-catenin signaling pathway was revealed to be involved in hepatocarcinogenesis and metastasis...
December 2018: Oncology Letters
Qin Wang, Handong Ding, Yinghua He, Xiaofeng Li, Yahui Chen, Qingqing Xu, Yue Yang, Guiyi Liao, Xiaoming Meng, Cheng Huang, Jun Li
NLRC5, a newly discovered member of the NLR family, has been reported to regulate immune responses and promote cell proliferation, migration, and invasion in hepatocellular carcinoma. However, to date, the potential regulatory roles and molecular mechanisms by which NLRC5 affects the development and progression of clear cell renal cell carcinoma (ccRCC) remain largely unknown. In this study, human clinical data from The Cancer Genome Atlas database revealed that increased NLRC5 expression was associated with advanced stage and poor prognosis in ccRCC patients...
December 10, 2018: Cancer Letters
İpek Even, İzzet Akiva, Necla Birgül İyison
BACKGROUND/AIMS: Aberrant activation of the Wnt/β-catenin signaling, which arises from the accumulation of mutant β-catenin in the cell, is one of the most common driving forces in hepatocellular carcinoma (HCC). We previously identified several genes that are regulated on the overexpression of β-catenin in the HCC cell line that are suggested to be novel Wnt/β-catenin targets playing effective roles in cancer. The aim of the present study was to elucidate the roles of these putative target genes in tumorigenesis with an in vivo analysis in Drosophila...
December 12, 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Fei Cao, Li-Xue Yin
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the primary causes of cancer-related death and resistance to cytotoxic chemotherapy is the major cause of mortality in HCC patients. miR-122 is a liver specific miRNA and is found to be reduced in HCC, however, the function of miR-122 in HCC chemosensitivity remains elusive. METHODS: We used qRT-PCR to measure expressions of miR-122, β-catenin and MDR1 in four HCC cell lines. And we assessed the effects of miR-122 or β-catenin on cell viability and apoptosis upon oxaliplatin (OXA) treatment by MTT assay and flow cytometry...
October 26, 2018: Experimental and Molecular Pathology
Zhi Liu, Yang Zhong, Yu Jian Chen, Hui Chen
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality. Identifying key molecules involved in the regulation of HCC development is of great clinical significance. SOX11 is a transcription factor belonging to group C of Sry-related HMG box family whose abnormal expression is frequently seen in many kinds of human cancers. Here, we reported that the expression of SOX11 was decreased in human HCC tumors than that in matched normal tissues. Overexpression of SOX11 promoted growth inhibition and apoptosis in HCC cell line HuH-7...
December 5, 2018: Biotechnology and Applied Biochemistry
Anindita Tripathy, Sudhir Thakurela, Manoj Kumar Sahu, Kanishka Uthanasingh, Manas Behera, Amrendra Kumar Ajay, Ratna Kumari
BACKGROUND: Hepatocellular carcinoma (HCC) is leading cause of cancer-related mortality and is categorized among the most common malignancies around the world. It is a heterogeneous tumor, which shows significant degree of histopathological heterogeneity. Despite the apparent histopathological diversity there has been very little distinct correlation between histopathological features and molecular aberrations particularly when it comes to the expression level of Wnt and Hh pathway molecules...
2018: PloS One
Ruiqi Liu, Yuejin Li, Lantian Tian, Huawen Shi, Jiabei Wang, Yingjian Liang, Boshi Sun, Shuangjia Wang, Meng Zhou, Li Wu, Jianhua Nie, Binlin Lin, Shuli Tang, Yanqiao Zhang, Guangyu Wang, Chunhui Zhang, Jiguang Han, Benjie Xu, Lianxin Liu, Kunmei Gong, Tongsen Zheng
Gankyrin plays important roles in tumorigenicity and metastasis of hepatocellular carcinoma (HCC). We have for the first time investigated the effects of Gankyrin on glycolysis and glutaminolysis both in vitro and in vivo, including in patient-derived xenografts. We reported Gankyrin increases glucose consumption, lactate production, glutamine consumption and glutamate production in HCC through upregulating the expression of the transporters and enzymes involved in glycolysis and glutaminolysis, including HK2, GLUT1, LDHA, PKM2, ASCT2 and GLS1...
November 29, 2018: Cancer Letters
Giuseppa Augello, Maria Rita Emma, Antonella Cusimano, Antonina Azzolina, Sarah Mongiovì, Roberto Puleio, Giovanni Cassata, Alessandro Gulino, Beatrice Belmonte, Roberto Gramignoli, Stephen C Strom, James A McCubrey, Giuseppe Montalto, Melchiorre Cervello
Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In this study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib)...
November 29, 2018: International Journal of Cancer. Journal International du Cancer
Gholamreza Bidkhori, Rui Benfeitas, Martina Klevstig, Cheng Zhang, Jens Nielsen, Mathias Uhlen, Jan Boren, Adil Mardinoglu
Hepatocellular carcinoma (HCC) is one of the most frequent forms of liver cancer, and effective treatment methods are limited due to tumor heterogeneity. There is a great need for comprehensive approaches to stratify HCC patients, gain biological insights into subtypes, and ultimately identify effective therapeutic targets. We stratified HCC patients and characterized each subtype using transcriptomics data, genome-scale metabolic networks and network topology/controllability analysis. This comprehensive systems-level analysis identified three distinct subtypes with substantial differences in metabolic and signaling pathways reflecting at genomic, transcriptomic, and proteomic levels...
November 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
Aichun Tan, Qiongxuan Li, Lizhang Chen
Circular RNAs (circRNAs) have been discovered to exert essential roles in human cancers, including hepatocellular carcinoma. Although circZFR has been reported to facilitate the growth of papillary thyroid cancer, the role of circZFR in hepatocellular carcinoma (HCC) are largely unknown. In this study, bioinformatics analysis showed that circZFR was closely related with hepatocellular carcinoma. We then detect the expression of circZFR in HCC tissues using qRT-PCR. Furthermore, Kaplan-Meier method and log rank test revealed that high expression of circZFR was associated with the poor prognosis of patients with HCC...
November 20, 2018: Archives of Biochemistry and Biophysics
Fei Huang, Junying Chen, Ruilong Lan, Zeng Wang, Ruiqing Chen, Jingan Lin, Lengxi Fu
Hypoxia frequently occurs in solid tumors, hepatocellular carcinoma included. Hypoxia-inducible factors (HIFs) upregulated in hypoxia can induce various downstream target genes to resist hypoxia stress, resulting in tumor growth, angiogenesis and metastasis in vivo. Therefore, hypoxia associated genes are usually cancer progression associated genes and can be potential therapy targets for cancer therapy. In our present work, we find that the hypoxia-inducible transcriptional factor, HIF1α, can directly upregulate the expression of the gene Ctnnd2, which codes the protein δ-Catenin...
November 17, 2018: Experimental Cell Research
Zhaoxia Hu, Peipei Wang, Jiaxin Lin, Xingrong Zheng, Fangji Yang, Genglin Zhang, Dabiao Chen, Junqiang Xie, Zhiliang Gao, Liang Peng, Chan Xie
BACKGROUND/AIMS: MicroRNA-197 (miR-197) has been shown to play roles in epithelialmesenchymal transition (EMT) and metastasis. The Wnt/β-catenin pathway is associated with EMT, but whether miR-197 regulatesWnt/β-catenin remains unclear. This study was to demonstrate the role of miR-197 on the Wnt/β-catenin pathway in hepatocellular carcinoma (HCC). METHODS: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-197 in 105 HCC specimens and 15 HCC cell lines...
2018: Cellular Physiology and Biochemistry
Maria J Perugorria, Paula Olaizola, Ibone Labiano, Aitor Esparza-Baquer, Marco Marzioni, Jose J G Marin, Luis Bujanda, Jesus M Banales
The canonical Wnt-β-catenin pathway is a complex, evolutionarily conserved signalling mechanism that regulates fundamental physiological and pathological processes. Wnt-β-catenin signalling tightly controls embryogenesis, including hepatobiliary development, maturation and zonation. In the mature healthy liver, the Wnt-β-catenin pathway is mostly inactive but can become re-activated during cell renewal and/or regenerative processes, as well as in certain pathological conditions, diseases, pre-malignant conditions and cancer...
November 19, 2018: Nature Reviews. Gastroenterology & Hepatology
Liying Zhu, Nenghong Yang, Guiqin Du, Chengcheng Li, Guoqi Liu, Shengju Liu, Yongjie Xu, Yanan Di, Wei Pan, Xing Li
Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote cell proliferation, migration, and invasion, while its molecular mechanisms were still largely unclear. In this study, we investigated the expression and function of CRNDE. CRNDE was significantly upregulated in tumor tissues compared with adjacent normal tissues. In vitro, we revealed that knockdown of CRNDE inhibited cell proliferation, migration, and cell invasion capacities in HCC...
November 14, 2018: Journal of Cellular Biochemistry
Yu-Ting Chou, Li-Yang Chen, Shin-Lin Tsai, Hsiao-Chen Tu, Jeng-Wei Lu, Shih-Ci Ciou, Horng-Dar Wang, Chiou-Hwa Yuh
Dysregulation of the enzymes involved in the pentose phosphate pathway (PPP) is known to promote tumorigenesis. Our recent study demonstrated that ribose-5-phosphate isomerase (RPIA), a key regulator of the PPP, regulates hepatoma cell proliferation and colony formation. Our studies in zebrafish reveal that RPIA-mediated hepatocarcinogenesis requires extracellular signal-regulated kinase (ERK) and β-catenin signaling. To further investigate RPIA-mediated hepatocarcinogenesis, two independent lines of transgenic zebrafish expressing human RPIA in the liver were generated...
November 12, 2018: Carcinogenesis
Di Qu, Feng Cui, Dan Lu, Yu Yang, Yuqing Xu
DEP domain containing 1 (DEPDC1) protein is a novel oncoantigen up-regulated in multi-type of cancers which presents oncogenic activity and high immunogenicity. However, the functional discovery and therapeutic potential of DEPDC1 in hepatocellular carcinoma (HCC) remain unclear. In this study, we demonstrated that DEPDC1 was frequently up-regulated in HCC and associated with cancer diagnosis and poor prognosis for HCC patients. Moreover, DEPDC1 promotes HCC cell proliferation in vitro as well as carcinogenesis in vivo...
November 12, 2018: Cancer Science
Ahmad M Al-Dali, Hans Weiher, Ingo G H Schmidt-Wolf
Once aberrantly activated, the Wnt/β-catenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against β-catenin, as it serves a role on the cytoplasm and the nucleus. In addition, specially-generated lymphocytes are recruited for the purpose of treating liver cancer. Peripheral blood mononuclear lymphocytes are expanded by the timely addition of interferon γ, interleukin (IL)-1β, IL-2 and anti-cluster of differentiation 3 antibody...
November 2018: Oncology Letters
Jussara Maria Gonçalves, Carolina Amália Barcellos Silva, Elena Riet Correa Rivero, Mabel Mariela Rodríguez Cordeiro
Over the past years, studies have described that users of antipsychotics are less likely to develop cancer than the population in general due to cytotoxic properties of this class of drugs on cancer cells. For this reason, Pimozide has been widely studied as a potential anticancer treatment, and satisfactory results in Melanoma, Central Nervous System Tumors, Osteosarcoma, Neuroblastoma, Myeloproliferative Neoplasms, Breast, Lung, Prostate, Ovarian, Colorectal, Pancreatic, and Hepatocellular Carcinoma have been showed...
November 1, 2018: Clinical and Experimental Pharmacology & Physiology
James J Harding, Subhiksha Nandakumar, Joshua Armenia, Danny N Khalil, Melanie Albano, Michele Ly, Jinru Shia, Jaclyn F Hechtman, Ritika Kundra, Imane El Dika, Richard K Do, Yichao Sun, T Peter Kingham, Michael I D'Angelica, Michael F Berger, David M Hyman, William R Jarnagin, David S Klimstra, Yelena Y Janjigian, David B Solit, Nikolaus Schultz, Ghassan K Abou-Alfa
PURPOSE: Prior molecular profiling of hepatocellular carcinoma (HCC) has identified actionable findings that may have a role in guiding therapeutic decision-making and clinical trial enrollment. We implemented prospective next-generation sequencing (NGS) in the clinic to determine whether such analyses provide predictive and/or prognostic information for HCC patients treated with contemporary systemic therapies. METHODS: Matched tumor/normal DNA from HCC patients (N=127) were analyzed using a hybridization capture-based, NGS assay designed to target 341 or more cancer-associated genes...
October 29, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Zhangjun Cheng, Zhengqing Lei, Pinghua Yang, Anfeng Si, Daimin Xiang, Jiahua Zhou, Norbert Hüser
Hepatocellular carcinoma (HCC) is a highly aggressive liver tumor containing cancer stem cells (CSCs), which participate in tumor invasion, therapeutic resistance, and tumor relapse leading to poor outcome and limited therapeutic options. Recently, a novel lncRNA, THOR (testis-associated highly conserved oncogenic long non-coding RNA), was characterized in human cancers and shown to exhibit an oncogenic role. However, the role of THOR in liver cancer stem cells (CSCs) remains obscure. Herein, we observed high expression of THOR in chemoresistant hepatocellular carcinomas (HCCs)...
October 22, 2018: Gene
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