keyword
https://read.qxmd.com/read/38520835/molecular-mechanisms-of-codonopsis-pilosula-in-inhibiting-hepatocellular-carcinoma-growth-and-metastasis
#1
JOURNAL ARTICLE
Ning Li, Ce Yang, Jing Xia, Wenxiang Wang, Wei Xiong
BACKGROUND: Liver cancer, one of the most common types of cancer worldwide, accounts for millions of cases annually. With its multi-target and wide-ranging therapeutic effects, traditional Chinese medicine has emerged as a potential approach for treating various tumors. Codonopsis pilosula, a traditional herb, is known for its anti-inflammatory and antioxidant properties. In this study, we investigated the potential molecular mechanisms of Codonopsis pilosula in regulating the inhibition of CDK1 and the modulation of PDK1/β-catenin, which are involved in hepatocellular carcinoma growth and metastasis...
January 7, 2024: Phytomedicine
https://read.qxmd.com/read/38506084/steroid-receptor-coactivator-1-promotes-human-hepatocellular-carcinoma-invasiveness-through-enhancing-mmp-9
#2
JOURNAL ARTICLE
Zhangwei Tong, Yong Zhang, Peng Guo, Wei Wang, Qiang Chen, Jing Jin, Shixiao Liu, Chundong Yu, Pingli Mo, Lei Zhang, Junli Huang
SRC-1 functions as a transcriptional coactivator for steroid receptors and various transcriptional factors. Notably, SRC-1 has been implicated in oncogenic roles in multiple cancers, including breast cancer and prostate cancer. Previous investigations from our laboratory have established the high expression of SRC-1 in human HCC specimens, where it accelerates HCC progression by enhancing Wnt/beta-catenin signalling. In this study, we uncover a previously unknown role of SRC-1 in HCC metastasis. Our findings reveal that SRC-1 promotes HCC metastasis through the augmentation of MMP-9 expression...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38492457/how-clspn-could-demystify-its-prognostic-value-and-potential-molecular-mechanism-for-hepatocellular-carcinoma-a-crosstalk-study
#3
JOURNAL ARTICLE
Yanlong Shi, Yizhu Wang, Kaiyi Niu, Wenning Zhang, Qingpeng Lv, Yewei Zhang
BACKGROUND & AIMS: CLSPN, a critical component of the S-phase checkpoint in response to DNA replication stress, has been implicated in the pathogenesis of multiple tumor types. The rising incidence of hepatocellular carcinoma (HCC) poses a significant challenge to global public health. Despite this, the specific functions of CLSPN in the development of HCC remain poorly understood. METHODS: We systematically evaluated the expression of CLSPN, prognosis and immune infiltration in patients with HCC and identified a competing endogenous RNA (ceRNA) network by using public database...
March 11, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38482965/molecular-pathological-approach-to-cancer-epigenomics-and-its-clinical-application
#4
REVIEW
Yae Kanai
Careful microscopic observation of histopathological specimens, accumulation of large numbers of high-quality tissue specimens, and analysis of molecular pathology in relation to morphological features are considered to yield realistic data on the nature of multistage carcinogenesis. Since the morphological hallmark of cancer is disruption of the normal histological structure maintained through cell-cell adhesiveness and cellular polarity, attempts have been made to investigate abnormalities of the cadherin-catenin cell adhesion system in human cancer cells...
March 14, 2024: Pathology International
https://read.qxmd.com/read/38481876/lncrna-hottip-facilitated-tumor-growth-via-stimulating-the-hnrnpa2b1-dkk1-wnt-%C3%AE-catenin-regulatory-axis-in-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Weiqiang Zeng, Chuanjian Shi, Liqiang Deng, Weiming Fu, Jinfang Zhang
No abstract text is available yet for this article.
July 2024: Genes & Diseases
https://read.qxmd.com/read/38481809/the-m6a-modification-mediated-positive-feedback-between-glycolytic-lncrna-slc2a1-dt-and-c-myc-promotes-tumorigenesis-of-hepatocellular-carcinoma
#6
JOURNAL ARTICLE
Zhu Zeng, Jie Wang, Fengyu Xu, Ping Hu, Yuhang Hu, Wenfeng Zhuo, Ding Chen, Shengbo Han, Fan Wang, Yong Zhao, Yan Huang, Gang Zhao
Glycolysis exerts a key role in the metabolic reprogramming of cancer. Specific long non-coding RNAs (lncRNAs) have been identified to exhibit oncogenic glycolysis regulation. Nevertheless, the precise mechanisms by which glycolysis-related lncRNAs control hepatocellular carcinoma (HCC) are still unknown. We profiled and analyzed glycolysis-associated lncRNA signatures using HCC specimens from The Cancer Genome Atlas (TCGA) dataset. Considerable upregulation of the glycolysis-related lncRNA SLC2A1-DT was noted in HCC tissues; this upregulation was strongly linked with advanced tumor stage and poor prognosis...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38468464/gins1-promotes-zeb1-mediated-epithelial-mesenchymal-transition-and-tumor-metastasis-via-%C3%AE-catenin-signaling-in-hepatocellular-carcinoma
#7
JOURNAL ARTICLE
Junjie Liang, Nan Yao, Bo Deng, Jinying Li, Yuchuan Jiang, Tongzheng Liu, Youzhu Hu, Mingrong Cao, Jian Hong
GINS1 regulates DNA replication in the initiation and elongation phases and plays an important role in the progression of various malignant tumors. However, the role of GINS1 in hepatocellular carcinoma (HCC) remains largely unclear. In this study, we investigated the role and underlying mechanisms of GINS1 in contributing to HCC metastasis. We found that GINS1 was significantly upregulated in HCC tissues and cell lines, especially in HCC tissues with vascular invasion and HCC cell lines with highly metastatic properties...
March 11, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38461536/echinacoside-ameliorates-hepatic-fibrosis-and-tumor-invasion-in-rats-with-thioacetamide-induced-hepatocellular-carcinoma
#8
JOURNAL ARTICLE
Ajwan Z Albalawi, Areej S Alatawi, Shekha M Al-Atwi, Lama S Alhwyty, Kadi M Alharbi, Shahad A Alshehri, Wasayf A Almarwani, Khulud K Aljohani, Hanan M Hassan, Mohammed M H Al-Gayyar
Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year. Despite advancements in HCC treatments, there is still a pressing need to identify new drugs that can combat resistance. One potential option is echinacoside, a natural caffeic acid glycoside with antioxidant, anti-inflammatory, antidepressant, and antidiabetic properties. Therefore, we aimed to investigate the ability of echinacoside to exhibit antitumor activity against HCC in rats through ameliorating hepatic fibrosis and tumor invasion...
March 10, 2024: Biomol Biomed
https://read.qxmd.com/read/38426809/elovl6-promotes-the-progression-of-head-and-neck-squamous-cell-carcinoma-via-activating-wnt-%C3%AE-catenin-pathway
#9
JOURNAL ARTICLE
Ruoya Wang, Xianzhi Liu, Xiyao Li, Ming Qian, Xi Yang, Qichuan Jiang, Yijie Wang, Hao Liu, Jianguo Chen, Xuefeng Wang, Liang Gong
This study was to explore the role of ELOVL6 in the development of head and neck squamous cell carcinoma (HNSCC). Considering its previously identified oncogenic role in hepatocellular carcinoma. ELOVL6 gene expression, clinicopathological analysis, enrichment analysis, and immune infiltration analysis were based on the data from Gene Expression Omnibus and The Cancer Genome Atlas, with additional bioinformatics analyses performed. Human HNSCC tissue microarray and cell lines were used. The expression of ELOVL6 in HNSCC was detected by quantitative polymerase chain reaction, immunohistochemistry assay, and western blot analysis...
March 1, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38421409/testosterone-%C3%AE-estradiol-and-hepatocellular-carcinoma-stimulation-or-inhibition-a-comparative-effect-analysis-on-cell-cycle-apoptosis-and-wnt-signaling-of-hepg2-cells
#10
JOURNAL ARTICLE
Fereshteh Barjesteh, Nafiseh Heidari-Kalvani, Iraj Alipourfard, Mohammad Najafi, Elham Bahreini
Unlike breast and prostate cancers, which are specifically affected by estrogens or androgens, hepatocellular carcinoma has been reported to be influenced by both sex hormones. Given the coincidental differences of hepatocellular carcinoma in men and women, we investigated the effects of β-estradiol and testosterone on the cell cycle, apoptosis, and Wnt signaling in a model of hepatocellular carcinoma to understand the sex hormone-related etiology. To determine the effective concentration of both hormones, an MTT assay was performed...
February 29, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38418544/targeting-the-ire1%C3%AE-xbp1s-axis-confers-selective-vulnerability-in-hepatocellular-carcinoma-with-activated-wnt-signaling
#11
JOURNAL ARTICLE
Tingting Zhang, Faming Zhao, Yi Zhang, Ji-Hua Shi, Fengzhen Cui, Weixiang Ma, Kai Wang, Chuanrui Xu, Qingping Zeng, Rong Zhong, Ningning Li, Yong Liu, Yang Jin, Xia Sheng
Liver-specific Ern1 knockout impairs tumor progression in mouse models of hepatocellular carcinoma (HCC). However, the mechanistic role of IRE1α in human HCC remains unclear. In this study, we show that XBP1s, the major downstream effector of IRE1α, is required for HCC cell survival both in vitro and in vivo. Mechanistically, XBP1s transactivates LEF1, a key co-factor of β-catenin, by binding to its promoter. Moreover, XBP1s physically interacts with LEF1, forming a transcriptional complex that enhances classical Wnt signaling...
February 28, 2024: Oncogene
https://read.qxmd.com/read/38417136/%C3%AE-catenin-activation-reprograms-ammonia-metabolism-to-promote-senescence-resistance-in-hepatocellular-carcinoma
#12
JOURNAL ARTICLE
Ye Wang, Chunxiao Cheng, Yanjun Lu, Zhaowu Lian, Qi Liu, Yanchao Xu, Yunzheng Li, Huan Li, Laizhu Zhang, Xiang Jiang, Binghua Li, Decai Yu
Hepatocellular carcinoma (HCC) is a typical tumor that undergoes metabolic reprogramming, differing from normal liver tissue in glucose, lipid, nucleic acid, and amino acid metabolism. While ammonia is a toxic metabolic byproduct, it has also been recently recognized as a signaling molecule to activate lipid metabolism, and it can be a nitrogen source for biosynthesis to support tumorigenesis. In this study, we revealed that β-catenin activation increases ammonia production in HCC mainly by stimulating glutaminolysis...
February 28, 2024: Cancer Research
https://read.qxmd.com/read/38411312/noncoding-rnas-and-programmed-cell-death-in-hepatocellular-carcinoma-significant-role-of-epigenetic-modifications-in-prognosis-chemoresistance-and-tumor-recurrence-rate
#13
REVIEW
Reza Arefnezhad, Sara Ashna, Fatemeh Rezaei-Tazangi, Seyed Mahdi Arfazadeh, Seyede Shabnam Seyedsalehie, Shaghayegh Yeganeafrouz, Melika Aghaei, Mandana Sanandaji, Ramin Davoodi, Sareh Ranjbar Karim Abadi, Massoud Vosough
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not been precisely defined so far. Hence, this review aimed to address the potential cross-talk between noncoding RNAs (ncRNAs) and programmed cell death in HCC. All related papers in the English language up to June 2023 were collected and screened. The searched keywords in scientific databases, including Scopus, PubMed, and Google Scholar, were HCC, ncRNAs, Epigenetic, Programmed cell death, Autophagy, Apoptosis, Ferroptosis, Chemoresistance, Tumor recurrence, Prognosis, and Prediction...
February 27, 2024: Cell Biology International
https://read.qxmd.com/read/38403027/crkl-dictates-anti-pd-1-resistance-by-mediating-tumor-associated-neutrophil-infiltration-in-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Peiyi Xie, Mincheng Yu, Bo Zhang, Qiang Yu, Yufei Zhao, Mengyuan Wu, Lei Jin, Jiuliang Yan, Binghai Zhou, Shuang Liu, Xiaoqiang Li, Chenhao Zhou, Xiaodong Zhu, Cheng Huang, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Lei Guo, Hui Li
BACKGROUND & AIMS: Immune checkpoint inhibitors (ICIs) resistance limits immunotherapy success in hepatocellular carcinoma (HCC). However, the mechanisms underlying immunotherapy resistance remain elusive. We aimed to identify the role of CT10 regulator of kinase-like (CRKL) in HCC against anti-PD-1 therapy. METHODS: Gene expression in HCC specimens from 10 patients accepted anti-PD-1 therapy was identified by RNA-sequencing. A total of 342 and 62 HCC samples from TMA1 and TMA2, respectively, were analyzed by immunohistochemistry...
February 23, 2024: Journal of Hepatology
https://read.qxmd.com/read/38400652/network-pharmacology-analysis-and-experimental-verification-of-the-antitumor-effect-and-molecular-mechanism-of-isocryptomerin-on-hepg2-cells
#15
JOURNAL ARTICLE
Jing-Long Cao, Shu-Mei Li, Yan-Jun Tang, Wen-Shuang Hou, An-Qi Wang, Tian-Zhu Li, Cheng-Hao Jin
Isocryptomerin (ISO) is a flavonoid isolated from the natural medicine Selaginellae Herba, which has various pharmacological activities. This study investigated the antitumor effect and underlying molecular mechanism of ISO on hepatocellular carcinoma (HCC) HepG2 cells. The cell viability assay revealed that ISO has a considerable killing effect on HCC cell lines. The apoptosis assay showed that ISO induced mitochondria-dependent apoptosis through the Bad/cyto-c/cleaved (cle)-caspase-3/cleaved (cle)-PARP pathway...
April 2024: Drug Development Research
https://read.qxmd.com/read/38394865/apigenin-enhances-sorafenib-anti-tumour-efficacy-in-hepatocellular-carcinoma
#16
JOURNAL ARTICLE
Deepti Singh, Mohammad Afsar Khan, Dhruv Mishra, Aditya Goel, Mairaj Ahmed Ansari, Kafil Akhtar, Hifzur R Siddique
BACKGROUND: The "one drug-one target" paradigm has various limitations affecting drug efficacy, such as resistance profiles and adverse effects. Combinational therapies help reduce unexpected off-target effects and accelerate therapeutic efficacy. Sorafenib- an FDA-approved drug for liver cancer, has multiple limitations. Therefore, it is recommended to identify an agent that increases its effectiveness and reduces toxicity. In this regard, Apigenin, a plant flavone, would be an excellent option to explore...
February 22, 2024: Translational Oncology
https://read.qxmd.com/read/38393550/phillygenin-inhibits-tgf-%C3%AE-1-induced-hepatic-stellate-cell-activation-and-inflammation-regulation-of-the-bax-bcl-2-and-wnt-%C3%AE-catenin-pathways
#17
JOURNAL ARTICLE
Cheng Wang, Shenglin Zhang, Yanzhi Li, Lihong Gong, Chenhao Yao, Ke Fu, Yunxia Li
Hepatic fibrosis (HF), a precursor to cirrhosis and hepatocellular carcinoma, is caused by abnormal proliferation of connective tissue and excessive accumulation of extracellular matrix in the liver. Notably, activation of hepatic stellate cells (HSCs) is a key link in the development of HF. Phillygenin (PHI, C21 H24 O6 ) is a lignan component extracted from the traditional Chinese medicine Forsythiae Fructus, which has various pharmacological activities such as anti-inflammatory, antioxidant and anti-tumour effects...
February 23, 2024: Inflammation
https://read.qxmd.com/read/38388484/laptm4b-mediated-hepatocellular-carcinoma-stem-cell-proliferation-and-mdsc-migration-implications-for-hcc-progression-and-sensitivity-to-pd-l1-monoclonal-antibody-therapy
#18
JOURNAL ARTICLE
Haojun Wang, Quanwei Zhou, Ding Fang Xie, Qingguo Xu, Tongwang Yang, Wei Wang
In hepatocellular carcinoma (HCC), immunotherapy is vital for advanced-stage patients. However, diverse individual responses and tumor heterogeneity have resulted in heterogenous treatment outcomes. Our mechanistic investigations identified LAPTM4B as a crucial gene regulated by ETV1 (a transcription factor), especially in liver cancer stem cells (LCSCs). The influence of LAPTM4B on LCSCs is mediated via the Wnt1/c-Myc/β-catenin pathway. CXCL8 secretion by LAPTM4B drove myeloid-derived suppressor cell (MDSC) migration, inducing unfavorable patient prognosis...
February 22, 2024: Cell Death & Disease
https://read.qxmd.com/read/38379270/ilkap-promotes-the-metastasis-of-hepatocellular-carcinoma-cells-by-inhibiting-%C3%AE-catenin-degradation-and-enhancing-the-wnt-signaling-pathway
#19
JOURNAL ARTICLE
Rui Zhang, Jinglei Yuan, Shicheng Liu, Vincenzo Torraca, Zhiquan Liao, Yueyan Wu, Hongfei Tan, Xia Yao, Xueyang Hou, Hao Lyu, Shuai Xiao, Dong Guo, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
The incidence of Hepatocellular carcinoma (HCC) and HCC-related deaths have remarkably increased over the recent decades. It has been reported that β-catenin activation can be frequently observed in HCC cases. This study identified the integrin-linked kinase-associated phosphatase (ILKAP) as a novel β-catenin-interacting protein. ILKAP is localized both in the nucleus and cytoplasm and regulates the WNT pathway in different ways. First, it is demonstrated that ILKAP activates the WNT pathway in HCC cells by increasing the protein level of β-catenin and other proteins associated with the WNT signaling, such as c-Myc and CyclinD1...
February 20, 2024: Advanced biology
https://read.qxmd.com/read/38379098/wnt-%C3%AE-catenin-signaling-pathway-in-liver-biology-and-tumorigenesis
#20
REVIEW
Shinji Matsumoto, Akira Kikuchi
The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway that controls fundamental physiological and pathological processes by regulating cell proliferation and differentiation. The Wnt/β-catenin pathway enables liver homeostasis by inducing differentiation and contributes to liver-specific features such as metabolic zonation and regeneration. In contrast, abnormalities in the Wnt/β-catenin pathway promote the development and progression of hepatocellular carcinoma (HCC)...
February 20, 2024: In Vitro Cellular & Developmental Biology. Animal
keyword
keyword
168954
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.