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Heart failure diabetes mellitus

S Zewari, L Hadi, F van den Elshout, R Dekhuijzen, Y Heijdra, P Vos
COPD and obesity often coexist and there is a complex interaction between them. Our aim was to evaluate the prevalence of obesity in a secondary care COPD population. Furthermore, the presence of comorbidities in obese (COPDOB ) and non-obese COPD (COPDNO ) individuals was studied. In 1654 COPD patients (aged ≥18 years) who visited a pulmonologist between January 2015 and December 2015, patient characteristics, pulmonary function tests and comorbidities were obtained from the medical records. Subjects were categorized according their BMI as underweight (<18...
December 4, 2018: COPD
Lia Alves-Cabratosa, Marc Elosua-Bayes, Maria García-Gil, Marc Comas-Cufí, Ruth Martí-Lluch, Anna Ponjoan, Jordi Blanch, Dídac Parramon, Manuel Angel Gomez-Marcos, Rafel Ramos
OBJECTIVE: Assessment of asymptomatic organ damage in the management of hypertension includes low (<0.9) ankle brachial index (ABI) values. No recommendations are given for patients with high ABI (≥1.3), despite evidence of an association with increased risk. We aimed to study the association of high ABI with all-cause mortality and cardiovascular outcomes in a hypertensive population. METHODS: In anonymized clinical records from the Catalan Primary Care (SIDIAP) database, we designed a large cohort of hypertensive patients aged 35-85 years at the start date...
January 2019: Journal of Hypertension
Robert B Hamanaka, Gökhan M Mutlu
Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air pollution varies greatly depending on the source, studies from across the world have consistently shown that air pollution is an important modifiable risk factor for significantly increased morbidity and mortality. Moreover, clinical studies have generally shown a greater impact of particulate matter (PM) air pollution on health than the gaseous components...
2018: Frontiers in Endocrinology
Syed Raza Shah, Sana Muhammad Iqbal, Richard Alweis, Steven Roark
Type 2 diabetes (T2D) is an independent risk factor for Heart Failure (HF). With concomitant T2D and HF, recent data suggests an incremental risk of cardiovascular death and hospitalization for HF, as compared to patients with HF without T2D. Areas covered: Management of these two diseases has been a challenge for physicians. The treatment goals for HF patients in T2D are very important. They serve as the end-point in using a specific treatment for management and treatment of T2D patients hence, decreasing mortality rates...
November 29, 2018: Expert Review of Clinical Pharmacology
(no author information available yet)
We are pleased to announce that the following 2 articles have been selected for the the UEDA Heart Awards for the Year 2018. First PlaceRole of Right Ventricular Dysfunction and Diabetes Mellitus in N-terminal pro-B-type Natriuretic Peptide Response of Patients With Severe Mitral Regurgitation and Heart Failure After MitraClipHidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian ButterInt Heart J 2017; 58 (2): 225-231. Second PlaceNanoparticle-Mediated Delivery of Pitavastatin to Monocytes/Macrophages Inhibits Left Ventricular Remodeling After Acute Myocardial Infarction by Inhibiting Monocyte-Mediated InflammationYajing Mao, Jun-ichiro Koga, Masaki Tokutome, Tetsuya Matoba, Gentaro Ikeda, Kaku Nakano, Kensuke EgashiraInt Heart J 2017; 58 (4): 615-623...
2018: International Heart Journal
Muhammad Saad, Umut Gomceli, Pranav Ravi, Andrisael G Lacoste, Neil Shah, Timothy J Vittorio
Heart failure (HF) is one of the leading causes of hospital readmissions and health care expenditures. With a vast degree of advancements in the clinical approach and diagnosis, its management protocol is limited in terms of enhancing quality of life and prognosis. Type 2 diabetes mellitus (T2DM) is considered as one of the commonly associated comorbid conditions in the HF population. The understanding of the molecular and metabolic models of HF has led to the utilization of therapeutic goals of T2DM in improving HF-related complications...
2018: Drugs in Context
Hussein Al-Rubaye, Giulia Perfetti, Juan-Carlos Kaski
The extensive collection of bacteria cohabiting within the host collaborates with human functions and metabolisms in both health and disease. The fine equilibrium of commensals is tightly controlled and an imbalance ("dysbiosis") in the gut microbiota can play different roles in human disease. The development of new genome sequencing techniques has allowed a better understanding of the role of human gut microbiota. This led to the identification of numerous metabolites produced in the gut, which have been suggested to play a role in human disease...
July 7, 2018: Current Problems in Cardiology
Koen W Streng, Jan F Nauta, Hans L Hillege, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Chim C Lang, Marco Metra, Leong L Ng, Piotr Ponikowski, Nilesh J Samani, Dirk J van Veldhuisen, Aeilko H Zwinderman, Faiez Zannad, Kevin Damman, Peter van der Meer, Adriaan A Voors
BACKGROUND: Comorbidities play a major role in heart failure. Whether prevalence and prognostic importance of comorbidities differ between heart failure with preserved ejection fraction (HFpEF), mid-range (HFmrEF) or reduced ejection fraction (HFrEF) is unknown. METHODS: Patients from index (n = 2516) and validation cohort (n = 1738) of The BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) were pooled. Eight non-cardiac comorbidities were assessed; diabetes mellitus, thyroid dysfunction, obesity, anaemia, chronic kidney disease (CKD, estimated glomerular filtration rate < 60 mL/min/1...
November 15, 2018: International Journal of Cardiology
Muthiah Vaduganathan, William B White, David M Charytan, David A Morrow, Yuyin Liu, Faiez Zannad, Christopher P Cannon, George L Bakris
A deeper understanding of the interplay between the renal axis and cardiovascular (CV) disease is needed in type 2 diabetes mellitus (T2DM). We aimed to explore the prognostic value of a comprehensive panel of renal biomarkers in patients with T2DM at high CV risk. We evaluated the prognostic performance of both serum (Cystatin C) and urine renal biomarkers (neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 protein, and indices of urinary protein excretion) in 5,380 patients with T2DM and recent acute coronary syndromes in the EXAMINE trial...
November 6, 2018: American Journal of Cardiology
Shanat Baig, Vishy Veeranna, Shaun Bolton, Nicola Edwards, Jeremy W Tomlinson, Konstantinos Manolopoulos, John Moran, Richard P Steeds, Tarekegn Geberhiwot
BACKGROUND: Alström syndrome (ALMS) is a very rare autosomal recessive monogenic disorder caused by a mutation in the ALMS1 gene and characterised by childhood onset obesity, dyslipidaemia, advanced non-alcoholic fatty liver disease, diabetes and extreme insulin resistance. There is evidence of multi-organ fibrosis in ALMS and severity of the disease often leads to organ failure with associated morbidities, resulting in reduced life expectancy. There are no specific treatments for this disease, and current management consists of only symptomatic therapies...
November 26, 2018: BMC Endocrine Disorders
Mattia Galli, Domenico D'Amario, Carmelo Sofia, Marcello Vaccarella, Filippo Crea, Nadia Aspromonte
Heart failure (HF) affects approximately 2% of the population worldwide, remaining a major cause of hospitalization and mortality despite innovative therapeutic approaches introduced in the past few decades. Type 2 diabetes mellitus (T2D) contributes significantly to end-organ damage and HF-related complications and is associated with worse clinical status and increased all-cause and cardiovascular mortality in patients with HF with reduced (HFrEF) or with preserved ejection fraction (HFpEF), compared to HF patients without T2D...
November 24, 2018: Expert Opinion on Drug Metabolism & Toxicology
Alvaro Garcia-Ropero, Juan J Badimon, Carlos G Santos-Gallego
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with high cardiovascular (CV) risk. Some of the therapeutic strategies are contraindicated in patients with concomitant heart disease. However, the newest antidiabetic medications, sodium-glucose cotransporter 2 (SGLT2) inhibitors, have shown to significantly reduce CV mortality and heart failure (HF) hospitalizations. The mechanism behind these surprising cardiac benefits remains unclear. Areas covered: This article reviews the pharmacokinetic, pharmacodynamics, efficacy and safety data for the different SGLT2 inhibitors...
November 21, 2018: Expert Opinion on Drug Metabolism & Toxicology
Chenchen Han, Yifan Li, Yang Wang, Dongqian Cui, Tingting Luo, Yuwen Zhang, Yang Ma, Wei Wei
G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important regulatory protein in the inflammatory immune response (IIR) by maintaining the balance between the function of inflammatory immune cells and non-conventional inflammatory immune cells and regulating inflammatory immune cell infiltration, inflammatory cytokine secretion, and the signaling associated with endothelial function. However, the imbalance of GRK2 expression and activity plays an important role in the development of IIR-related diseases, such as hypertension, heart failure, Alzheimer's disease, type 2 diabetes mellitus, insulin resistance, rheumatoid arthritis, thyroid cancer, multiple sclerosis, and liver cancer...
2018: Cellular Physiology and Biochemistry
Tomoaki Murakami, Yoko Horibata, Shigeru Tateno, Yasutaka Kawasoe, Koichiro Niwa
Arginine vasopressin (AVP), which induces vasoconstriction and conserves solute-free water when released during high plasma osmolality, is secreted through 2 mechanisms: osmoregulation and baroregulation. This study aims to clarify the mechanisms and influencing factors for non-osmotic AVP secretion in adult patients with congenital heart disease (CHD). AVP levels were measured in 74 adults with CHD. Non-osmotic AVP secretion was defined as excessive AVP secretion relative to the AVP level inferred from plasma osmolality...
November 20, 2018: Heart and Vessels
Faleha Zafar, Waseem Tariq, Raja Farhat Shoaib, Ahmed Shah, Maimoona Siddique, Abdullah Zaki, Salman Assad
Background: The purpose of this study was to determine the frequency of ischemic stroke subtypes based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification at a tertiary care center in Pakistan. Materials and Methods: A cross-sectional study was conducted in Stroke Unit of Shifa International Hospital, Islamabad. We included 145 patients who presented to us from November 2015 to February 2016 with radiological confirmed neurological deficits consistent with ischemic stroke...
October 2018: Asian Journal of Neurosurgery
Brittany N Burton, Naeemah A Munir, Angele S Labastide, Ramon A Sanchez, Rodney A Gabriel
OBJECTIVE: The impact of race on outcomes after coronary artery bypass graft (CABG) has been reported before the enactment of the Patient Protection and Affordable Care Act. However, the impact of race on outcomes post-Affordable Care Act enactment remains unclear. The authors evaluated the association of race with outcomes after enactment of the Affordable Care Act in CABG patients. DESIGN: Retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program database from 2012 to 2016...
October 22, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Young Ae Kim, Hyunsoon Cho, Nayoung Lee, So-Youn Jung, Sung Hoon Sim, In Hae Park, Sunmi Lee, Eun Sook Lee, Hak Jin Kim
BACKGROUND: Doxorubicin is a typical anticancer drug that causes cardiomyopathy and heart failure (HF). The aim of our study was to investigate incidence, risk factors for doxorubicin-induced HF in Korean cancer patients and their survival rate, utilizing a nationwide population-based cohort. METHODS: We analyzed 58 541 cancer patients who received doxorubicin between 2003 and 2010. Descriptive analysis was performed in patients with breast cancer, hematologic malignancy, gynecological malignancy, and sarcoma...
November 19, 2018: Cancer Medicine
LaTonya J Hickson, Wigdan H Farah, Rebecca L Johnson, Bjorg Thorsteinsdottir, Daniel S Ubl, Brandon J Yuan, Robert Albright, Andrew D Rule, Elizabeth B Habermann
Introduction: It is unknown whether patients receiving dialysis have a higher morbidity and mortality risk after hip fracture repair conferred by their kidney failure or by the high comorbidity burden often present. Methods: We examined associations of dialysis dependency with postoperative complications, death, and readmission in a matched cohort study of U.S. patients undergoing hip fracture repair, from January 2010 to December 2013, in the American College of Surgeons National Surgical Quality Improvement Program...
November 2018: KI Reports
Anjan Tibrewala, Clyde W Yancy
Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent condition, particularly in women. Comorbidities, including older age, obesity, diabetes mellitus, hypertension, and hyperlipidemia, are risk factors and define phenotypic profiles of HFpEF in women. The condition has a relatively high burden of morbidity and mortality, with phenotypic profiles potentially characterizing risk of hospitalization and mortality. Based on limited data, nonpharmacologic and pharmacologic treatments may provide benefit; however, compelling evidence-based, disease-modifying treatments are needed...
January 2019: Heart Failure Clinics
A Zapatero-Gaviria, R Gómez-Huelgas, J Canora-Lebrato, J Ena-Muñoz, M Romero-Sánchez, M Mendez-Bailón, J Marco-Martínez, R Barba-Martín
OBJECTIVES: Diabetes mellitus is associated with a marked increase in cardiovascular disease. In this study, we analysed the prevalence of diabetes mellitus in hospitalised patients in Spain in 2015 and the burden of associated cardiovascular disease. METHODS: By analysing the 2015 minimum basic data set (MBDS) of the Spanish Ministry of Health, we included all patients discharged with a diagnosis of diabetes mellitus. We describe the epidemiological characteristics, distribution by the various hospital departments and the presence of cardiovascular disease...
November 15, 2018: Revista Clínica Española
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