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Heart failure diabetes mellitus

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https://www.readbyqxmd.com/read/30107798/overweight-and-obesity-impair-left-ventricular-systolic-function-as-measured-by-left-ventricular-ejection-fraction-and-global-longitudinal-strain
#1
Peter Blomstrand, Peter Sjöblom, Mats Nilsson, Magnus Wijkman, Martin Engvall, Toste Länne, Fredrik H Nyström, Carl Johan Östgren, Jan Engvall
AIMS: Obesity is associated with type 2 diabetes mellitus, left ventricular diastolic dysfunction and heart failure but it is unclear to which extent it is related to left ventricular systolic dysfunction. The aim of the study was to explore the effects of overweight and obesity on left ventricular systolic function in patients with type 2 diabetes mellitus and a control group of non-diabetic persons. METHODS: We prospectively investigated 384 patients with type 2 diabetes mellitus, and 184 controls who participated in the CARDIPP and CAREFUL studies...
August 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/30107568/a-multi-center-case-control-study-of-the-effect-of-acute-rejection-and-cytomegalovirus-infection-on-pneumocystis-pneumonia-pcp-in-solid-organ-transplant-recipients
#2
S M Hosseini-Moghaddam, M Shokoohi, G Singh, S F Dufresne, A Boucher, A Jevnikar, G V R Prasad, A Shoker, D Kabbani, M Hebert, H Cardinal, I Houde, A Humar, D Kumar
Background: Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between post-transplant PCP and 3 variables: cytomegalovirus infection, allograft rejection and prophylaxis. Methods: Eight transplantation centers participated. For each case (SOT recipient with PCP), 3-5 controls (SOT recipients without PCP) were included. Controls were matched to the cases based on transplant center, type of allograft and date of transplantation (± 6 months)...
August 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30104821/heart-failure-with-preserved-ejection-fraction-hfpef-implications-for-the-anesthesiologists
#3
REVIEW
Ajmer Singh, Yatin Mehta
Heart failure (HF) is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. American College of Cardiology Foundation / American Heart Association 2013 guidelines have classified HF into two categories: (i) HF with reduced (≤40%) ejection fraction (HFrEF) or systolic HF, and (ii) HF with preserved (≥50%) ejection fraction (HFpEF) or diastolic HF. Risk factors for HFpEF include age more than 70 years, female gender, hypertension, wide pulse pressure, diabetes mellitus, chronic renal insufficiency, left ventricular hypertrophy, atrial fibrillation, smoking, recent weight gain, and exercise intolerance...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/30102498/impact-of-socio-demographic-characteristics-and-long-term-complications-on-quality-of-life-in-patients-with-diabetes-mellitus
#4
Miodrag Stojanović, Goran Cvetanović, Marija Anđelković-Apostolović, Dijana Stojanović, Nataša Rančić
OBJECTIVE: Diabetes mellitus (DM) has been one of the leading chronic diseases worldwide over past decades. The objective of the study was to identify predictors associated with health-related quality of life (HRQOL) in diabetic patients. METHODS: A cross-sectional questionnaire-based study was conducted at the General Hospital of the city of Leskovac, between June and November 2015. The Short Form-36 (SF-36) questionnaire, EuroQol-5D (EQ-5D) and EuroQol-VAS (EQ-VAS) questionnaires were used...
June 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/30100217/national-trends-in-diabetes-mellitus-hospitalization-in-spain-1997-2010-analysis-of-over-5-4-millions-of-admissions
#5
Carmen M Lara-Rojas, Luis M Pérez-Belmonte, María D López-Carmona, Ricardo Guijarro-Merino, María R Bernal-López, Ricardo Gómez-Huelgas
AIMS: To analyze national trends in the rates of hospitalizations (all-cause and by principal discharge diagnosis) in total diabetic population of Spain. METHODS: We carried out a nation-wide population-based study of all diabetic patients hospitalized between 1997 and 2010. All-cause hospitalizations, hospitalizations by principal discharge diagnosis, mean age, Charlson Comorbidity Index, readmission rates and length of hospital stay were examined. Annual rates adjusted for age and sex were analyzed and trends were calculated...
August 9, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/30098964/antihyperglycemic-therapies-to-treat-patients-with-heart-failure-and-diabetes-mellitus
#6
REVIEW
Abhinav Sharma, Lauren B Cooper, Mona Fiuzat, Robert J Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O'Connor, Faiez Zannad
There is increasing recognition of the relationship between diabetes and heart failure (HF). Comorbid diabetes is associated with worse outcomes in patients with HF, and death from HF forms a large burden of mortality among patients with diabetes and atherosclerotic cardiovascular disease. However, there is evidence of harm relating to the risk of HF outcomes from several antihyperglycemic therapies. The absence of well-powered randomized controlled studies has resulted in significant treatment variations in the glycemic management in patients with coexisting diabetes and HF...
August 7, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/30097335/association-of-body-mass-index-and-diastolic-function-in-metabolically-healthy-obese-with-preserved-ejection-fraction
#7
Zach Rozenbaum, Yan Topilsky, Shafik Khoury, David Pereg, Michal Laufer-Perl
BACKGROUND: Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction. METHODS AND RESULTS: Echocardiograms of metabolically healthy patients between 2011 and 2016, who had no significant valvulopathies or atrial fibrillation, and had preserved ejection fraction, were retrospectively identified and analyzed...
August 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30094473/activating-transcription-factor-3-in-cardiovascular-diseases-a-potential-therapeutic-target
#8
REVIEW
Heng Zhou, Ning Li, Yuan Yuan, Ya-Ge Jin, Haipeng Guo, Wei Deng, Qi-Zhu Tang
Cardiovascular diseases (CVDs) are the primary causes of death worldwide. Among the numerous signaling molecules involved in CVDs, transcriptional factors directly influence gene expression and play a critical role in regulating cell function and the development of diseases. Activating transcription factor (ATF) 3 is an adaptive-response gene in the ATF/cAMP responsive element-binding (CREB) protein family of transcription factors that acts as either a repressor or an activator of transcription via the formation of homodimers or heterodimers with other ATF/CREB members...
August 9, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/30093255/french-society-of-cardiology-guidelines-on-exercise-tests-part-2-indications-for-exercise-tests-in-cardiac-diseases
#9
Dany-Michel Marcadet, Bruno Pavy, Gilles Bosser, Frédérique Claudot, Sonia Corone, Hervé Douard, Marie-Christine Iliou, Bénédicte Vergès-Patois, Pascal Amedro, Thierry Le Tourneau, Caroline Cueff, Taniela Avedian, Alain Cohen Solal, François Carré
The exercise test is performed routinely in cardiology; its main indication is the diagnosis of myocardial ischemia, evaluated along with the subject's pretest probability and cardiovascular risk level. Other criteria, such as analysis of repolarization, must be taken into consideration during the interpretation of an exercise test, to improve its predictive value. An exercise test is also indicated for many other cardiac diseases (e.g. rhythm and conduction disorders, severe asymptomatic aortic stenosis, hypertrophic cardiomyopathy, peripheral artery disease, hypertension)...
August 6, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/30091215/risk-of-heart-failure-in-type-2-diabetes-population-comparison-with-non-diabetes-subjects-with-and-without-coronary-heart-diseases
#10
Hua-Fen Chen, Ching-An Ho, Chung-Yi Li
BACKGROUND: Population-based study comparing age- and sex-specific risk estimates of heart failure (HF) between patients with type 2 diabetes and non-diabetes subjects was limited in number. In addition, the risks of HF in association with type 2 diabetes in people with various coronary heart diseases (CHDs) have rarely been investigated. This study used a nationally representative sample (one-million people) selected from Taiwan's National Health Insurance (NHI) to clarify the above-mentioned research questions...
August 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30087233/recognizing-obesity-in-adult-hospitalized-patients-a-retrospective-cohort-study-assessing-rates-of-documentation-and-prevalence-of-obesity
#11
Mohammad A Hossain, Ami Amin, Anju Paul, Huzaif Qaisar, Monika Akula, Alireza Amirpour, Shreya Gor, Sofi Giglio, Jennifer Cheng, Roy Mathew, Tushar Vachharajani, Mohamed Bakr, Arif Asif
BACKGROUND: While obesity is a chronic condition that predisposes patients to other more serious disorders, the prevalence and the documentation of obesity as diagnosis has not been extensively studied in hospitalized patients. We conducted a retrospective chart review to investigate the prevalence and documentation of obesity as a diagnosis among patients admitted to our medical center. METHOD: IRB approval was obtained for this retrospective study. Body mass index (BMI) as per CDC, admission and discharge diagnosis of obesity and common comorbidities (hypertension, diabetes, hyperlipidemia, coronary artery disease, congestive heart disease, chronic kidney disease and chronic obstructive pulmonary disease) were recorded...
August 7, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30084785/impact-of-aortic-valve-replacement-on-glycemic-control-in-diabetes-mellitus
#12
Peter Michael Rodgers-Fischl, Daniel Davenport, Sibu Saha, Maya Guglin
Introduction: The Framingham Studies revealed that diabetes mellitus (DM) predisposed subjects to a two- to eight-fold increase in the risk of developing heart failure (HF). However, there is much less information available about the reverse issue; namely, whether there is an increased risk of developing DM in patients with HF. We sought to determine if reversal or partial reversal of HF through aortic valve replacement (AVR) would improve glycemic control in patients with DM at our institution...
July 12, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/30081813/-chronic-heart-failure-and-diabetes-mellitus-pathogenesis-and-possibilities-of-treatment
#13
A G Obrezan, N V Kulikov
In this article we present data of scientific studies of prevalence of diabetes mellitus (DM) among patients with chronic heart failure (CHF), pathogenetic and risk factors of CHF development patients with DM (hyperglycemia, elevated body mass index, age, ischemic heart disease, nephropathy, proteinuria, DM duration, etc.). The article also contains results of analysis of mortality of patients with and without DM in dependence of ejection fraction value. After characterization of drugs for treatment of CHF in general and specifically in patients with DM we make focus on perspective directions in treatment of this group of patients...
July 2018: Kardiologiia
https://www.readbyqxmd.com/read/30081800/-relationship-between-levels-of-sex-hormones-and-response-to-cardiac-resynchronisation-therapy-in-men
#14
T N Enina, V A Kuznetsov, A M Soldatova, T I Petelina, D V Krinochkin, S M Dyachkov, A Y Rychkov, T Y Gorbunova
AIM: To study the relationship between levels of sex hormones and effectiveness of cardiac resynchronisation therapy (CRT) in men with chronic heart failure (CHF). MATERIALS AND METHODS: The best response to CRT (mean time, 38 [19,0;53,7] months) was identifed by a maximum decrease in left ventricular end-systolic volume (LVESV) in 58 men (mean age, 54.8±9.6) with CHF (61% IHD). Based on testosterone (TES) level, patients were divided into group 1 (n=28; 48%) - TES < median value (13...
2018: Kardiologiia
https://www.readbyqxmd.com/read/30075873/cardiac-and-renal-effects-of-sodium-glucose-co-transporter-2-inhibitors-in-diabetes-jacc-state-of-the-art-review
#15
REVIEW
Thomas A Zelniker, Eugene Braunwald
Patients with type 2 diabetes mellitus have an increased risk for the development of cardiac and other vascular events, heart failure (HF), and decline in renal function. After several large cardiovascular outcome trials with mostly neutral results, 2 studies of the sodium-glucose co-transporter 2 inhibitors (SGLT2is), empagliflozin and canagliflozin, reported favorable effects on the primary endpoint, a composite of myocardial infarction, stroke, and cardiovascular death. In addition, reductions of hospitalizations for HF were observed; in the case of empagliflozin, reductions in both cardiovascular mortality and total mortality occurred...
July 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30075542/association-of-early-loss-of-primary-functional-patency-of-arteriovenous-access-with-mortality-in-incident-hemodialysis-patients-a-nationwide-population-based-observational-study
#16
Chung-Kuan Wu, Chia-Hsun Lin, Chih-Cheng Hsu, Der-Cherng Tarng, Chew-Teng Kor, Yi-Chun Chen, Chia-Lin Wu, Chia-Chu Chang
The long-term survival and life quality of hemodialysis (HD) patients depend on adequacy of dialysis via a well-functioning vascular access. Loss of primary functional patency (PFP) of an arteriovenous access (AVA) eventually happens in HD patients. The association between time to loss of PFP of AVAs and mortality in HD patients remains unclear. The retrospective nationwide population-based cohort study compared the hazards of mortality with time to loss of PFP. We enrolled 1618 adult incident HD patients who received HD via AVAs for at least 90 days between January 1, 2001 and December 31, 2013...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30074530/mineralocorticoid-receptor-antagonist-utilization-in-a-nationally-representative-heart-failure-with-reduced-ejection-fraction-outpatient-population-a-cross-sectional-study
#17
Kayla Rena Joyner, Mate Michael Soric, Jaclyn Ann Boyle, John Michael Moorman, Mary Elizabeth Fredrickson, Jodie Zlotnik Turosky, Casondra Lee Kleven
BACKGROUND: Mineralocorticoid receptor antagonists (MRAs) improve survival among patients with heart failure with reduced ejection fraction (HFrEF); however, studies have identified low utilization rates. No study has evaluated the prevalence and predictors of MRA prescribing in a nationally representative outpatient cohort. STUDY QUESTION: What is the prevalence and predictors of MRA prescribing among outpatients with HFrEF in the United States? STUDY DESIGN: A national cross-sectional secondary analysis of the National Ambulatory Medical Care Survey from 2007 to 2014 including all office visits for HFrEF in patients aged >55 years...
July 25, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/30071860/regulation-of-diabetic-cardiomyopathy-by-caloric-restriction-is-mediated-by-intracellular-signaling-pathways-involving-sirt1-and-pgc-1%C3%AE
#18
Maayan Waldman, Keren Cohen, Dor Yadin, Vadim Nudelman, Dan Gorfil, Michal Laniado-Schwartzman, Ran Kornwoski, Dan Aravot, Nader G Abraham, Michael Arad, Edith Hochhauser
BACKGROUND: Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure. Cardiomyopathy is initially characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and fibrosis, both of which are aggravated by angiotensin. Caloric restriction (CR) is cardioprotective in animal models of heart disease through its catabolic activity and activation of the expression of adaptive genes...
August 2, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/30067203/-at-the-heart-of-diabetic-cardiomyopathy-bscl2-knockout-mice-to-investigate-glucotoxicity
#19
Alexandre Lugat, Michael Joubert, Bertrand Cariou, Xavier Prieur
Type 2 diabetes mellitus (T2DM) is a well-recognized independent risk factor for heart failure (HF). T2DM is associated with altered cardiac energy metabolism, leading to ectopic lipid accumulation and glucose overload. However, the relative contribution of these two parameters remains unclear. In order to get new insight into the mechanism involved in diabetic cardiomyopathy, the cardiac phenotype of a unique T2DM mice model has been performed: the seipin knockout mice (SKO). Cardiac phenotyping revealed a diastolic dysfunction associated with hyperglycemia in these mice with a chronic activation of the hexosamine biosynthetic pathway (HBP), suggesting a glucose overload...
June 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/30063421/obesity-ectopic-fat-and-cardiac-metabolism
#20
Marie-Eve Piché, Paul Poirier
Obesity is recognized as a risk factor for cardiovascular disease, expending independent adverse effects on the cardiovascular system. This relationship is complex due to several associations with cardiovascular disease risk factors/markers such as hypertension, dyslipidemia, insulin resistance/dysglycemia, or type 2 diabetes mellitus. Obesity induces a variety of cardiovascular system structural adaptations, from subclinical myocardial dysfunction to severe left ventricular systolic heart failure. Abnormalities in cardiac metabolism and subsequent cardiac energy, have been proposed as major contributors to obesity-related cardiovascular disease...
July 2018: Expert Review of Endocrinology & Metabolism
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