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Heart failure related diabetes

Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, Peter Sartipy
The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients...
October 20, 2018: Stem Cell Reviews
Markus Wallner, Deborah M Eaton, Dirk von Lewinski, Harald Sourij
PURPOSE OF THE REVIEW: To summarize current clinical data investigating the link between diabetes and heart failure pathophysiology, the association of glucose control with heart failure, and the impact of current antihyperglycemic drugs on heart failure. RECENT FINDINGS: Although heart failure is one of the most prevalent outcomes occurring in real life and cardiovascular outcome trials, insufficient attention was given to this condition in diabetes research over the last decades...
October 20, 2018: Current Diabetes Reports
Eric Shulman, Jay J Chudow, Utibe R Essien, Anusha Shanbhag, Faraj Kargoli, Jorge Romero, Luigi Di Biase, John Fisher, Andrew Krumerman, Kevin J Ferrick
BACKGROUND: Contribution of modifiable risk factors for the risk of new onset atrial fibrillation (AF) in minority populations is poorly understood. Our objective was to compare the population attributable risk (PAR) of various risk factors for incident AF between Hispanic, African American and non-Hispanic Whites. METHODS: An ECG/EMR database was interrogated for individuals free of AF for development of subsequent AF from 2000 to 2013. Cox regression analysis controlled for age > 65, male gender, body mass index > 40 kg/m2 , systolic blood pressure > 140 mm Hg, diabetes mellitus, heart failure, socioeconomic status less than the first percentile in New York State, and race/ethnicity...
October 10, 2018: International Journal of Cardiology
Jawad H Butt, Jonas B Olesen, Eva Havers-Borgersen, Anna Gundlund, Charlotte Andersson, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Emil L Fosbøl
BACKGROUND: The long-term risk of thromboembolism in patients developing new-onset post-operative atrial fibrillation (POAF) following noncardiac surgery is unknown, and data on stroke prophylaxis in this setting are lacking. OBJECTIVES: The purpose of this study was to assess the long-term risk of thromboembolism in patients developing new-onset POAF following noncardiac surgery relative to patients with nonsurgical, nonvalvular atrial fibrillation (NVAF). METHODS: Using Danish nationwide registries, the authors identified all patients who developed POAF following noncardiac surgery from 1996 to 2015...
October 23, 2018: Journal of the American College of Cardiology
D Aune, S Schlesinger, M Neuenschwander, T Feng, I Janszky, T Norat, E Riboli
BACKGROUND AND AIM: The strength of the association between diabetes and risk of heart failure has differed between previous studies and the available studies have not been summarized in a meta-analysis. We therefore quantified the association between diabetes and blood glucose and heart failure in a systematic review and meta-analysis. METHODS AND RESULTS: PubMed and Embase databases were searched up to May 3rd 2018. Prospective studies on diabetes mellitus or blood glucose and heart failure risk were included...
July 25, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Geir Hirlekar, Martin Jonsson, Thomas Karlsson, Jacob Hollenberg, Per Albertsson, Johan Herlitz
BACKGROUND: Patients suffering out-of-hospital cardiac arrest (OHCA) have a poor prognosis but survival among subgroups differs greatly. Previous studies have shown conflicting results on whether patient comorbidity affects outcome. The aim of this national study was to investigate the effect of comorbidity on outcome after OHCA in Sweden. METHODS: We included all patients with bystander-witnessed OHCA from 2011‒2015 in the national Swedish Registry of Cardiopulmonary Resuscitation...
October 10, 2018: Resuscitation
Josje D Schoufour, Jessica C Kiefte-de Jong, Trudy Voortman
OBJECTIVE: We aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. DESIGN: We studied 9,701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45 years and over. METHOD: Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200g/d), fruit (≥200g/d), whole-grains (≥90g/d), legumes (≥135g/wk), nuts (≥15g/d), dairy (≥350g/d), fish (≥100g/wk), tea (≥450mL/d), ratio whole-grains:total grains (≥50%), ratio unsaturated fats & oils:total fats (≥50%), red and processed meat (<300g/wk), sugar-containing beverages (<150mL/d), alcohol (<10 g/d) and salt (≤6g/d)...
September 19, 2018: Nederlands Tijdschrift Voor Geneeskunde
Iain C Macdougall, Claire White, Stefan D Anker, Sunil Bhandari, Kenneth Farrington, Philip A Kalra, John J V McMurray, Heather Murray, Retha Steenkamp, Charles R V Tomson, David C Wheeler, Christopher G Winearls, Ian Ford
BACKGROUND: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown. METHODS: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incident HD adults with a serum ferritin < 400 µg/L and transferrin saturation (TSAT) levels < 30% receiving erythropoiesis-stimulating agents (ESA) were eligible...
October 10, 2018: American Journal of Nephrology
Luca Faconti, Charlotte Elizabeth Mills, Virginia Govoni, Haotian Gu, Steven Morant, Benju Jiang, J Kennedy Cruickshank, Webb James Andrew
AIMS: To explore whether long-term intervention with dietary nitrate ((NO3 - ), a potential tolerance-free source of beneficial vasoactive nitric oxide) and spironolactone (to oppose aldosterone's potential deleterious cardiovascular effects) improve cardiac structure/function, independent of blood pressure (BP), in patients with/at risk of type 2 diabetes (a population at risk of heart failure). METHODS: A sub-sample of participants in our double-blind, randomised, factorial-design intervention (VaSera) trial of active beetroot juice as a nitrate source (≤11...
October 7, 2018: British Journal of Clinical Pharmacology
Sara B Seidelmann, Elena Feofanova, Bing Yu, Nora Franceschini, Brian Claggett, Mikko Kuokkanen, Hannu Puolijoki, Tapani Ebeling, Markus Perola, Veikko Salomaa, Amil Shah, Josef Coresh, Elizabeth Selvin, Calum A MacRae, Susan Cheng, Eric Boerwinkle, Scott D Solomon
BACKGROUND: Loss-of-function mutations in the SGLT1 (sodium/glucose co-transporter-1) gene result in a rare glucose/galactose malabsorption disorder and neonatal death if untreated. In the general population, variants related to intestinal glucose absorption remain uncharacterized. OBJECTIVES: The goal of this study was to identify functional SGLT1 gene variants and characterize their clinical consequences. METHODS: Whole exome sequencing was performed in the ARIC (Atherosclerosis Risk in Communities) study participants enrolled from 4 U...
October 9, 2018: Journal of the American College of Cardiology
Andrea Hetzenecker, Christoph Fisser, Stefan Stadler, Michael Arzt
In 2017 the German Sleep Society (Deutsche Gesellschaft für Schlafforschung und Schlafmedizin, DGSM) published the new S3 guideline "Nonrestorative Sleep/Sleep Disorders, chapter "Sleep-Related Breathing Disorders in Adults".Sleep apnea contributes to an increased morbidity and mortality in patients with cardiovascular diseases, e. g. coronary heart disease, heart failure and diabetes mellitus and is associated with an increased perioperative risk. It is also an important comorbidity in respiratory, neurologic and oncologic diseases...
October 2018: Deutsche Medizinische Wochenschrift
Prashanthi Vemuri, Timothy G Lesnick, Scott A Przybelski, Jonathan Graff-Radford, Robert I Reid, Val J Lowe, Samantha M Zuk, Matthew L Senjem, Christopher G Schwarz, Jeffrey L Gunter, Kejal Kantarci, Mary M Machulda, Michelle M Mielke, Ronald C Petersen, David S Knopman, Clifford R Jack
OBJECTIVE: Recent availability of amyloid and tau PET has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of AD pathologies. We wanted to quantify early cerebrovascular health related MRI brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health. METHODS: We used two independent samples (Discovery: n= 390; Validation: n=1035) of individuals, aged ≥60 years, along the cognitive continuum with imaging from the population-based sample of Mayo Clinic Study of Aging...
September 28, 2018: Annals of Neurology
Paul A Scuffham, Joshua M Byrnes, Christine Pollicino, David Cross, Stan Goldstein, Shu-Kay Ng
BACKGROUND: Disease management programmes may improve quality of care, improve health outcomes and potentially reduce total healthcare costs. To date, only one very large population-based study has been undertaken and indicated reductions in hospital admissions > 10%. OBJECTIVE: We sought to confirm the effectiveness of population-based disease management programmes. The objective of this study was to evaluate the relative impact on healthcare utilisation and cost of participants the Costs to Australian Private Insurance - Coaching Health (CAPICHe) trial...
September 27, 2018: Journal of General Internal Medicine
Pedro J Tárraga López, M José Villar Inarejos, Ibrahim M Sadek, Fátima Madrona Marcos, Loreto Tárraga Marcos, Miguel Ángel Simón García
OBJECTIVE: To analyse the heart failure situation in a health area, as well quality criteria. METHOD: Cross-sectional observational study of patients diagnosed with heart failure by collecting data from their clinical history in the «Turriano» computer program. The variables analysed were, comorbidities, control of cardiovascular risk factors, treatments, number of chronic diseases, and admissions. The level of adherence to drugs in relation to heart failure by determining the ratio between the percentage of prescribed drugs and drugs withdrawn from pharmacy is also analysed using the Turriano prescription program...
September 24, 2018: Clínica e Investigación en Arteriosclerosis
Satoshi Ida, Ryutaro Kaneko, Kazuya Murata
BACKGROUND: We used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes. METHODS: Document searches were implemented using Medline, Cochrane Controlled Trials Registry, and We decided to include RCTs that evaluated the impact of LVM using the administration of OADs to patients with type 2 diabetes. The outcome evaluations used standardized mean difference (SMD) and 95% confidence intervals (CIs)...
September 27, 2018: Cardiovascular Diabetology
Michael A Nauck, John B Buse, Johannes F E Mann, Stuart Pocock, Heidrun Bosch-Traberg, Helle Frimer-Larsen, Qing Ye, Alastair Gray
AIMS: Health-related quality of life (HRQoL) is an important outcome for patients with type 2 diabetes (T2D). HRQoL was assessed in the LEADER cardiovascular outcomes trial using the European Quality of Life - 5 Dimensions (EQ-5D) instrument. MATERIALS AND METHODS: The EQ-5D was administered every 12 months in a subset of patients from Canada, Denmark, Germany, Ireland, Italy, Netherlands, Spain, Sweden, UK and US. We compared changes in utility index scores and visual analogue scale (VAS) scores from baseline to 36 months in patients treated with liraglutide and placebo...
September 27, 2018: Diabetes, Obesity & Metabolism
Reinhold Kreutz, Insa M Schmidt, Dagmar Dräger, Franca Brüggen, Stefan Hörter, Christine Zwillich, Adelheid Kuhlmey, Paul Gellert
AIM: Evidence on antithrombotic therapy use in centenarians diagnosed with atrial fibrillation (AF) is sparse. Our objective was to investigate a possible underprescribing in centenarians relative to younger cohorts of the oldest-old. We assumed lower AF rates; and, within AF patients, lower use of anticoagulants in those who died as centenarians (aged ≥100 years) than in those who died aged in their 80s (≥80 years) or 90s (≥90 years). METHODS: The present study was a quarterly structured cohort study over the 6 years before death using administrative data from German institutionalized and non-institutionalized insured patients (whole sample n = 1398 and subsample of AF patients n = 401 subclassified according to age-of-death groups [≥80, ≥90, ≥100 years])...
September 26, 2018: Geriatrics & Gerontology International
Yan-Guang Li, Gregory Y H Lip
Stroke prevention is the cornerstone of the management of patients with atrial fibrillation (AF). Individual stroke risk stratification is generally the first step of deciding whether oral anticoagulation (OAC) will benefit patients with AF. Given that existing approaches to the prediction of 'high-risk' subjects are of limited value, the initial focus should be the identification of 'low-risk' patients who do not need antithrombotic therapy. For this, the CHA2 DS2 -VASc score (congestive heart failure, hypertension, age ≥ 75 [2 points], diabetes mellitus, previous stroke/transient ischemic attack [2 points], vascular disease, age 65-74, female sex) performs well in identifying really low-risk patients (score of 0 in males or 1 in females), for whom OAC can be omitted...
September 19, 2018: International Journal of Cardiology
Hsin-Bang Leu, Wei-Hsian Yin, Wei-Kung Tseng, Yen-Wen Wu, Tsung-Hsien Lin, Hung-I Yeh, Kuan- Cheng Chang, Ji-Hung Wang, Chau-Chung Wu, Jaw-Wen Chen
BACKGROUND: Some personality types are associated with cardiovascular (CV) diseases and may be related to clinical outcomes in coronary artery disease (CAD). This study investigates the association between type D personality and clinical outcomes in stable CAD patients in an Asian cohort. METHODS: Stable CAD patients were enrolled and prospectively followed up for at least 1 year in Taiwan. The inclusion criteria were at least one successful percutaneous coronary intervention (PCI) and stable medical treatment for at least 1 month before enrollment...
September 19, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Kyle H Cichos, Jessica L Churchill, Sierra G Phillips, Shawna L Watson, Gerald McGwin, Elie S Ghanem, Brent A Ponce
INTRODUCTION: Hip fractures and metabolic syndrome (MetS) are becoming major global healthcare burdens as populations age. This study sought to determine the impact of MetS in hip fracture patients on perioperative outcomes following operative fixation or arthroplasty. METHODS: Data from the 2004-2014 Nationwide Inpatient Sample was used to select 3,348,207 discharges with hip fracture. MetS patients were identified by having at least 3 of 4 component comorbidities: hypertension, dyslipidemia, obesity, and diabetes...
September 8, 2018: Injury
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