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Intraventricular Haemorrhage

Sasank Chilamkurthy, Rohit Ghosh, Swetha Tanamala, Mustafa Biviji, Norbert G Campeau, Vasantha Kumar Venugopal, Vidur Mahajan, Pooja Rao, Prashant Warier
BACKGROUND: Non-contrast head CT scan is the current standard for initial imaging of patients with head trauma or stroke symptoms. We aimed to develop and validate a set of deep learning algorithms for automated detection of the following key findings from these scans: intracranial haemorrhage and its types (ie, intraparenchymal, intraventricular, subdural, extradural, and subarachnoid); calvarial fractures; midline shift; and mass effect. METHODS: We retrospectively collected a dataset containing 313 318 head CT scans together with their clinical reports from around 20 centres in India between Jan 1, 2011, and June 1, 2017...
October 11, 2018: Lancet
David Churchill, Lelia Duley, Jim G Thornton, Mahmoud Moussa, Hind Sm Ali, Kate F Walker
BACKGROUND: Severe pre-eclampsia can cause significant mortality and morbidity for both mother and child, particularly when it occurs remote from term, between 24 and 34 weeks' gestation. The only known cure for this disease is delivery. Some obstetricians advocate early delivery to ensure that the development of serious maternal complications, such as eclampsia (fits) and kidney failure are prevented. Others prefer a more expectant approach, delaying delivery in an attempt to reduce the mortality and morbidity for the child that is associated with being born too early...
October 5, 2018: Cochrane Database of Systematic Reviews
K L Hon, S Liu, J Cy Chow, K Yc Tsang, H S Lam, K W So, Y Ky Cheng, A Kc Leung, W Wong
BACKGROUND: Extremely low birth weight (ELBW) infants exhibit high rates of mortality and morbidity. We retrospectively assessed factors associated with mortality and morbidity among ELBW infants. METHODS: Perinatal demographic data were reviewed for all ELBW infants born between 2010 and 2017 at a tertiary neonatal unit. RESULTS: For non-survivors (21% of ELBW infants) and survivors, the median gestational ages were 24.1 and 26.2 weeks, respectively, and median birth weights were 650 g and 780 g, respectively (all P<0...
October 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Georgios Tsivgoulis, Duncan Wilson, Aristeidis H Katsanos, João Sargento-Freitas, Cláudia Marques-Matos, Elsa Azevedo, Tomohide Adachi, Christian von der Brelie, Yoshifusa Aizawa, Hiroshi Abe, Hirofumi Tomita, Ken Okumura, Joji Hagii, David J Seiffge, Vasileios-Arsenios Lioutas, Christopher Traenka, Panayiotis Varelas, Ghazala Basir, Christos Krogias, Jan C Purrucker, Vijay K Sharma, Timolaos Rizos, Robert Mikulik, Oluwaseun A Sobowale, Kristian Barlinn, Hanne Sallinen, Nitin Goyal, Shin-Joe Yeh, Theodore Karapanayiotides, Teddy Y Wu, Konstantinos Vadikolias, Marc Ferrigno, Georgios Hadjigeorgiou, Rik Houben, Sotirios Giannopoulos, Floris H B M Schreuder, Jason J Chang, Luke A Perry, Maximilian Mehdorn, João-Pedro Marto, João Pinho, Jun Tanaka, Marion Boulanger, Rustam Al-Shahi Salman, Hans R Jäger, Clare Shakeshaft, Yusuke Yakushiji, Philip M C Choi, Julie Staals, Charlotte Cordonnier, Jiann-Shing Jeng, Roland Veltkamp, Dar Dowlatshahi, Stefan T Engelter, Adrian R Parry-Jones, Atte Meretoja, Panayiotis Mitsias, Andrei V Alexandrov, Gareth Ambler, David J Werring
OBJECTIVE: Whether intracerebral haemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin-K antagonists (VKA-ICH) is uncertain. METHODS: We performed a systematic review and individual patient data meta-analysis of cohort studies comparing clinical and radiological outcomes between NOAC-ICH and VKA-ICH patients. The primary outcome measure was 30-day all-cause mortality...
September 26, 2018: Annals of Neurology
Victoria Yj Tay, Srinivas Bolisetty, Barbara Bajuk, Kei Lui, John Smyth
AIM: To evaluate trends in admission temperature and its effect on mortality and short-term morbidities in extremely preterm infants. METHODS: A regional cohort study of infants born at 23-28 weeks' gestation and admitted to the 10 neonatal intensive care units in New South Wales and the Australian Capital Territory between 1994 and 2012. Hypothermia was defined as skin temperature <36°C on admission to the neonatal intensive care unit. The primary outcome was hospital mortality...
September 15, 2018: Journal of Paediatrics and Child Health
Ursula Kiechl-Kohlendorfer, Marlene Biermayr, Ulrike Pupp Peglow, Elke Griesmaier
Objective This study aimed to determine survival, neonatal morbidity, and outcomes at 1 and 2 years in children who were born very preterm, and to analyse any relation to enteral feeding. Methods We performed a prospective, observational study on very preterm infants (range: 23-31 weeks' gestation) born at Innsbruck Medical University Hospital, Austria, between 2007 and 2014 (n = 557). Results The overall survival rate was 94.6%. Survival rates were 77.8%, 78.6%, 90.9%, and 90.9% among those born at 24, 25, 26, and 27 weeks, and 97...
August 29, 2018: Journal of International Medical Research
Susan Ireland, Sarah Larkins, Robin Ray, Lynn Woodward, Kirsty Devine
AIM: The Townsville Hospital cares for babies in a large geographical area, many of who are outborn, are of Aboriginal or Torres Strait Islander origin and have families who reside in areas of deprivation. This study examined the outcomes of babies born at all locations in North Queensland to assess the predictors of poor outcomes. METHODS: A retrospective observational study examined the survival of 313 babies born from 22 completed weeks gestation to 27 + 6 weeks gestation in North Queensland between January 2010 and December 2016...
August 27, 2018: Journal of Paediatrics and Child Health
Sonia Rodríguez-Fernández, Encarnación Castillo-Lorente, Francisco Guerrero-Lopez, David Rodríguez-Rubio, Eduardo Aguilar-Alonso, Jesús Lafuente-Baraza, Francisco Javier Gómez-Jiménez, Juan Mora-Ordóñez, Ricardo Rivera-López, María Dolores Arias-Verdú, Guillermo Quesada-García, Miguel Ángel Arráez-Sánchez, Ricardo Rivera-Fernández
OBJECTIVE: Validation of the intracerebral haemorrhage (ICH) score in patients with a diagnosis of spontaneous ICH admitted to the intensive care unit (ICU). METHODS: A multicentre cohort study was conducted in all consecutive patients with ICH admitted to the ICUs of three hospitals with a neurosurgery department between 2009 and 2012 in Andalusia, Spain. Data collected included ICH, Glasgow Coma Scale (GCS) and Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores...
August 13, 2018: BMJ Open
Yan Liu, Zenghui Pu, Maomao Zhao
A 70-year-old woman was adimittetd with subarachnoid haemorrhage. The patient underwent cerebral aneurysm embolization. On hospital day 14, the patient underwent a lumbar subarachnoid continuous drain insertion because of fever and enlarged ventricles were showed on the head computed tomography. On hospital day 19, the patient presented with remittent fever (peak at 39.1 °C) associated with altered mental status. Cerebro-Spinal Fluid (CSF) revealed white blood cell (WBC) count of 53484/mm3 (polymorphonucleocytes,75...
August 13, 2018: Antimicrobial Agents and Chemotherapy
Mark Dzietko, Soeren Schulz, Michael Preuss, Christoph Haertel, Anja Stein, Ursula Felderhoff-Mueser, Wolfgang Goepel
AIM: Infants born preterm are at risk of intraventricular haemorrhage (IVH) but individual susceptibility related to genes is not well defined in this vulnerable population. Apolipoprotein genotypes APOE2 and APOE4 increase the hazard of cerebral haemorrhages in adults. We investigated whether APOE is associated with prevalence of IVH and is likely to have a particular genotype. METHOD: In this prospective study, 5075 infants born preterm with genotype APOE3 were compared to 965 (APOE2) and 1912 (APOE4) individuals, to analyse the association between APOE genotype and grade III and IV IVH...
August 7, 2018: Developmental Medicine and Child Neurology
Malgorzata Sobolewska-Pilarczyk, Katarzyna Pawlak-Osinska, Sylwia Drewa, Beata Smok, Małgorzata Pawlowska
Congenital Cytomegalovirus infection (CCMV) is the most common intrauterine infection. Early diagnosis of CCMV is hindered by three factors: There is no screening programme for CMV infection in pregnant women; a high percentage of infections in neonates are asymptomatic; the clinical signs of CCMV infection are uncharacteristic. The aim of this article is to analyse the clinical picture and course of CCMV treatment in a 3-week-old newborn, analyse adverse events in 14-week-long antiviral therapy and also assess intraventricular bleeding as an early indicator for the diagnosis of CCMV...
April 2018: Indian Journal of Medical Microbiology
Anoop Pahuja, Katie Hunt, Vadivelam Murthy, Prashanth Bhat, Ravindra Bhat, Anthony D Milner, Anne Greenough
Intraventricular haemorrhage (IVH) and bronchopulmonary dysplasia (BPD) are major complications of premature birth. We tested the hypotheses that prematurely born infants who developed an IVH or BPD would have high expiratory tidal volumes (VTE ) (VTE  > 6 ml/kg) and/or low-end tidal carbon dioxide (ETCO2 ) levels (ETCO2 levels < 4.5 kPa) as recorded by respiratory function monitoring or hyperoxia (oxygen saturation (SaO2 ) > 95%) during resuscitation in the delivery suite. Seventy infants, median gestational age 27 weeks (range 23-33), were assessed; 31 developed an IVH and 43 developed BPD...
November 2018: European Journal of Pediatrics
I Iwuchukwu, N Mahale, J Ryder, B Hsieh, B Jennings, D Nguyen, K Cornwell, R Beyl, J Zabaleta, M Sothern
Objective: This study was conducted to determine the role of obesity and race in intracerebral haemorrhage (ICH) outcomes. Methods: The Get with the guideline-Stroke database was queried for all admitted patients with spontaneous ICH. Secondary causes of ICH were excluded. Body mass index (BMI) was classified using the Center for Disease Control guidelines. Race was classified as White or non-White. Demographics, clinical, imaging data were retrieved. Outcome measures were hematoma expansion at 24 h and discharge disposition...
June 2018: Obesity Science & Practice
Bo Du, Ai-Jun Shan, Yu-Ping Peng, Jin Wang, Kai-Wen Peng, Xian-Liang Zhong, Yujuan Zhang
BACKGROUND: Minimally invasive endoscopic haematoma evacuation is widely used in the treatment of intraventricular haemorrhage. However, its technique still has room for improvement. A new modified neuroendoscope technology (MNT) was used in this study and we explored its safety and efficacy in the treatment of severe acute intraventricular haemorrhage by comparing it with extraventricular drainage plus urokinase thrombolytic (EVD + UT) therapy. METHODS: The following parameters were compared between the MNT group and the control group: incision design, operation time, ICU monitoring time, ventricular drainage tube (VDT) placement time, post-operative drainage tube obstruction (PDTO) rate, post-operative complications rate, 6-month mortality and Glasgow Outcome Scale (GOS)...
2018: Brain Injury: [BI]
Janet B Sharpe, Mark W Davies
AIM: The risk of mortality and morbidity is increased in outborn, extremely premature infants. We aim to determine whether earlier arrival of the retrieval team after the birth of infants less than 29 weeks gestation improves short-term mortality and morbidity. METHODS: This is a retrospective analysis of a cohort of infants less than 29 weeks gestation who were retrieved to the Royal Brisbane and Women's Hospital (RBWH) over a 5-year period. Demographic information regarding the infant and mother, retrieval team arrival time and outcome data was collected...
May 31, 2018: Journal of Paediatrics and Child Health
Deepanjan Bhattacharya, Indar Kumar Sharawat, Lokesh Saini
No abstract text is available yet for this article.
May 30, 2018: BMJ Case Reports
Morag J Andrew, Jeremy R Parr, Christine Montague-Johnson, Karen Laler, Jane Holmes, Bonny Baker, Peter B Sullivan
AIM: To investigate whether neonates at risk for neurodevelopmental impairment have improved neurodevelopment after docosahexaenoic acid, choline, and uridine-5-monophosphate supplementation versus controls. METHOD: Recruitment was from UK neonatal units. Eligible for inclusion were infants born at less than 31 weeks' gestation with a weight less than the ninth centile; infants born at less than 31 weeks' gestation with a grade II or higher intraventricular haemorrhage/preterm white matter injury; infants born between 31 weeks' and 40 weeks' gestation plus 28 days with a grade II or higher intraventricular haemorrhage/preterm white matter injury, moderate or severe hypoxic-ischaemic encephalopathy, or defined neuroimaging abnormalities...
September 2018: Developmental Medicine and Child Neurology
L N Yelland, E Schuit, J Zamora, P F Middleton, A C Lim, A H Nassar, L Rode, V Serra, E A Thom, C Vayssière, Bwj Mol, S Gates
OBJECTIVE: To estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies. DESIGN: Secondary analysis of data from 12 RCTs. SETTING: Obstetric care in multiple countries, 2004-2012. POPULATION OR SAMPLE: 4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy...
October 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Erik A Jensen, Elizabeth E Foglia, Kevin C Dysart, Rebecca A Simmons, Zubair H Aghai, Alison Cook, Jay S Greenspan, Sara B DeMauro
OBJECTIVE: To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation. METHODS: Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies...
May 5, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Kei Lui, Lisa J Jones, Jann P Foster, Peter G Davis, See Kwee Ching, Ju Lee Oei, David A Osborn
BACKGROUND: Initial resuscitation with air is well tolerated by most infants born at term. However, the optimal fractional inspired oxygen concentration (FiO2 - proportion of the breathed air that is oxygen) targeted to oxygen saturation (SpO2 - an estimate of the amount of oxygen in the blood) for infants born preterm is unclear. OBJECTIVES: To determine whether lower or higher initial oxygen concentrations, when titrated according to oxygen saturation targets during the resuscitation of preterm infants at birth, lead to improved short- and long-term mortality and morbidity...
May 4, 2018: Cochrane Database of Systematic Reviews
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