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Periventricular Leucomalacia

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https://www.readbyqxmd.com/read/29434061/immediate-neonatal-outcomes-of-preterm-infants-born-to-mothers-with-preterm-pre-labour-rupture-of-membranes
#1
Niveditha Dannapaneni, Tejopratap Oleti, Tarakeswari Surapaneni, Deepak Sharma, Srinivas Murki
Background & objectives: With the use of early and appropriate use of antibiotics, outcomes have improved in the mother-infant dyads exposed to preterm pre-labour rupture of membranes (PPROM). This study was undertaken to evaluate immediate neonatal outcomes in infants born before 33 completed weeks of gestation to mothers with PPROM versus without PPROM. Methods: During the study period from January 2013 to December 2013, a total of 182 mother-infant dyads were prospectively included in the study...
October 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28663283/t-piece-versus-self-inflating-bag-ventilation-in-preterm-neonates-at-birth
#2
Ruth Guinsburg, Maria Fernanda Branco de Almeida, Junia Sampel de Castro, Walusa Assad Gonçalves-Ferri, Patricia Franco Marques, Jamil Pedro Siqueira Caldas, Vera Lucia Jornada Krebs, Ligia Maria Suppo de Souza Rugolo, João Henrique Carvalho Leme de Almeida, Jorge Hecker Luz, Renato S Procianoy, José Luiz Muniz Bandeira Duarte, Marcia Gomes Penido, Daniela Marques de Lima Mota Ferreira, Navantino Alves Filho, Edna Maria de Albuquerque Diniz, Juliana Paula Santos, Ana Lucia Acquesta, Cristina Nunes Dos Santos, Maria Rafaela Conde Gonzalez, Regina Pg Vieira Cavalcanti da Silva, Jucile Meneses, José Maria de Andrade Lopes, Franciscó Eulógio Martinez
OBJECTIVE: To verify whether the use of the T-piece resuscitator compared with the self-inflating bag in preterm infants ventilated at birth modifies survival to hospital discharge without major morbidities. DESIGN: Pragmatic prospective cohort study. SETTING: 20 Brazilian university hospitals of Brazilian Network on Neonatal Research. Patients were 1962 inborn infants in 2014-2015 ventilated at birth with 23-33' weeks gestation and birth weight 400-1499 g without malformations...
January 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27729347/respiratory-distress-syndrome-in-moderately-late-and-late-preterm-infants-and-risk-of-cerebral-palsy-a-population-based-cohort-study
#3
Sandra Kruchov Thygesen, Morten Olsen, John R Østergaard, Henrik Toft Sørensen
OBJECTIVES: Infant respiratory distress syndrome (IRDS) is a known risk factor for intracerebral haemorrhage/intraventricular haemorrhage (ICH/IVH) and periventricular leucomalacia. These lesions are known to increase the risk of cerebral palsy (CP). Thus, we wanted to examine the long-term risk of CP following IRDS in moderately late and late preterm infants. DESIGN: Population-based cohort study. SETTING: All hospitals in Denmark. PARTICIPANTS: We used nationwide medical registries to identify a cohort of all moderately and late preterm infants (defined as birth during 32-36 full gestational weeks) born in Denmark in 1997-2007 with and without hospital diagnosed IRDS...
October 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27404120/immediate-versus-deferred-delivery-of-the-preterm-baby-with-suspected-fetal-compromise-for-improving-outcomes
#4
REVIEW
Sarah J Stock, Leanne Bricker, Jane E Norman, Helen M West
BACKGROUND: Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity. OBJECTIVES: To assess the effects of immediate versus deferred delivery of preterm babies with suspected fetal compromise on neonatal, maternal and long-term outcomes. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 April 2016) and reference lists of retrieved studies...
July 12, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27170932/should-dopamine-be-the-first-line-inotrope-in-the-treatment-of-neonatal-hypotension-review-of-the-evidence
#5
Sadaf I Bhayat, Harsha M S Gowda, Michael Eisenhut
AIM: To determine if dopamine is effective in treating neonatal hypotension and safe to use comparing to other inotropes. METHODS: This is a review of evidence on inotropic treatment of neonatal hypotension. Databases searched were MEDLINE and the Cochrane Library, a total of 134 studies were identified. Only studies with high quality evidence (level 1a and b and 2a) were included. After review, only eight studies were included in the final analysis. Pooled risk ratios derived for each outcome [Mantel-Haenzel (M-H) fixed effect] with CI, as reported in the Cochrane reviews were plotted in forest plot form...
May 8, 2016: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/26781425/cox-1-and-cox-2-polymorphisms-in-susceptibility-to-cerebral-palsy-in-very-preterm-infants
#6
Helena Kapitanović Vidak, Tina Catela Ivković, Zoran Vidak, Sanja Kapitanović
Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain. Recent epidemiological and clinical data suggest intrauterine infection/inflammation as the most common cause of preterm delivery and neonatal complications, including CP. Cyclooxygenases are key enzymes in the conversion of arachidonic acid to prostaglandins. The COX family consists of two isoforms, COX-1 and COX-2. In the brain, COX-2 is constitutively expressed at high levels on pyramidal neurons, while COX-1 is predominantly expressed by microglia and can be upregulated in pathological conditions, such as infection, ischemia and traumatic brain injury...
March 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/26318030/prediction-of-late-death-or-disability-at-age-5-years-using-a-count-of-3-neonatal-morbidities-in-very-low-birth-weight-infants
#7
MULTICENTER STUDY
Barbara Schmidt, Robin S Roberts, Peter G Davis, Lex W Doyle, Elizabeth V Asztalos, Gillian Opie, Aida Bairam, Alfonso Solimano, Shmuel Arnon, Reginald S Sauve
OBJECTIVE: To evaluate bronchopulmonary dysplasia (BPD), serious brain injury, and severe retinopathy of prematurity (ROP) as predictors of poor long-term outcome in very low birth weight infants. STUDY DESIGN: We examined the associations between counts of the 3 morbidities and long-term outcomes in 1514 of 1791 (85%) infants with birth weights of 500-1250 g who were enrolled in the Caffeine for Apnea of Prematurity trial from October 1999, to October 2004, had complete morbidity data, and were alive at 36 weeks postmenstrual age (PMA)...
November 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/25939374/does-fetal-growth-restriction-lead-to-increased-brain-injury-as-detected-by-neonatal-cranial-ultrasound-in-premature-infants
#8
Atul Malhotra, Zamir Yahya, Arun Sasi, Graham Jenkin, Michael Ditchfield, Graeme R Polglase, Suzanne L Miller
AIM: Intra-uterine growth restriction (IUGR) is an important cause for prematurity as well as a significant risk factor for neurodevelopmental deficits. In this study, we aimed to examine the association between IUGR and early brain injury on neonatal cranial ultrasound in preterm infants. METHODS: This retrospective cohort study examined the relationship between IUGR and neonatal cranial ultrasound findings in preterm infants <32 weeks gestation with IUGR, compared with gestation and year of birth-matched appropriately grown infants, in a tertiary level neonatal unit...
November 2015: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/25774537/conservative-management-of-preterm-premature-rupture-of-membranes-beyond-32-weeks-gestation-is-it-worthwhile
#9
Z Tsafrir, G Margolis, Y Cohen, A Cohen, I Laskov, I Levin, D Mandel, A Many
We aimed to investigate whether conservative management of preterm premature rupture of membranes (PPROM) at 32-34 weeks' gestation improves outcome. In this retrospective analysis of singleton pregnancies, the study group included patients with PPROM at 28-34 weeks' gestation and the control group included patients presented with spontaneous preterm delivery at 28-34 weeks' gestation. Both groups were subdivided according to gestational age - early (28-31 weeks' gestation) versus late (32-34 weeks' gestation)...
2015: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/25617864/the-neuropathology-of-stillbirth-correlation-with-apolipoprotein-genotype-in-a-scottish-population-based-study
#10
Jeanne Elisabeth Bell, Julie-Clare Becher, Jean Winifred Keeling, Neil McIntosh
BACKGROUND: The neuropathology of stillbirths has been widely studied but rarely on a population basis. Whether foetal apolipoprotein E (APOE) genotype exerts any influence has been little investigated, despite well known effects in adult brains. AIMS: To establish the neuropathology of a population cohort of stillbirths and compare with the APOE genotype. STUDY DESIGN AND SUBJECTS: The brains of 191 stillbirths (≥24weeks of gestation) were recruited from a Scottish population cohort and grouped by clinical history...
February 2015: Early Human Development
https://www.readbyqxmd.com/read/25145002/the-role-of-antibiotic-prophylaxis-in-preterm-premature-rupture-of-membranes
#11
Vesna Elvedi Gasparović, Snjezana Gverić Ahmetasević, Petrana Beljan
Preterm premature rupture of membranes (PPROM) occurs in 3 percent of all pregnancies and is responsible for, or associated with, approximately one-third of preterm births causing significant perinatal morbidity and fetal death. Preterm infants are very vulnerable to respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), periventricular leucomalacia (PVL), other neurological sequelae, infection and necrotizing enterocolitis (NEC). Chorioamnionitis based on clinical criteria occurs in approximately 3-30% of all PPROM pregnancies...
June 2014: Collegium Antropologicum
https://www.readbyqxmd.com/read/25097737/the-effects-on-apgar-scores-and-neonatal-outcomes-of-switching-from-a-combination-of-phenylephrine-and-ephedrine-to-phenylephrine-alone-as-a-prophylactic-vasopressor-during-spinal-anesthesia-for-cesarean-section
#12
Joo Yeon Jeon, In Ho Lee, Young Seok Jee, Pil Moo Lee, Seung In Park, Hea-Jo Yoon
BACKGROUND: Ephedrine, unlike phenylephrine, has a dose-related propensity to depress fetal pH during spinal anesthesia during cesarean section. A low arterial umbilical cord pH has a strong association with neonatal mortality and morbidity. The purpose of this retrospective study was to investigate influences of vasopressor change on Apgar scores and adverse neonatal outcomes in cesarean section. METHODS: In obstetric anesthesia, we changed the prophylactic vasopressor from a combination of phenylephrine and ephedrine to phenylephrine alone in 2000...
July 2014: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/25026255/intracranial-dynamics-in-pre-term-infants-and-neonates-implications-for-physiotherapists
#13
J Paratz, Y Burns
The control of cerebral circulation and intracranial dynamics differs markedly in the pre-term and full term neonate from that in the adult. Immaturity can combine with several clinical conditions and iatrogenic factors to predispose the neonate to cerebral lesions, which may subsequently increase morbidity. As physiotherapists play an increasingly important role in neonatology, it is important to appreciate the immaturity of the nervous system and to recognise the risk factors for such conditions as peri-intraventricular haemorrhage and periventricular leucomalacia...
1993: Australian Journal of Physiotherapy
https://www.readbyqxmd.com/read/24964139/spatial-patterns-of-whole-brain-grey-and-white-matter-injury-in-patients-with-occult-spastic-diplegic-cerebral-palsy
#14
Xuetao Mu, Binbin Nie, Hong Wang, Shaofeng Duan, Zan Zhang, Guanghui Dai, Qiaozhi Ma, Baoci Shan, Lin Ma
Spastic diplegic cerebral palsy (SDCP) is a common type of cerebral palsy (CP), which presents as a group of motor-impairment syndromes. Previous conventional MRI studies have reported abnormal structural changes in SDCP, such as periventricular leucomalacia. However, there are roughly 27.8% SDCP patients presenting normal appearance in conventional MRI, which were considered as occult SDCP. In this study, sixteen patients with occult SDCP and 16 age- and sex-matched healthy control subjects were collected and the data were acquired on a 3T MR system...
2014: PloS One
https://www.readbyqxmd.com/read/24864020/col4a1-mutations-should-not-be-a-contraindication-for-epilepsy-surgery
#15
Apostolos Papandreou, Martin M Tisdall, W K Chong, J Helen Cross, William F Harkness, Sophia M Varadkar
PURPOSE: We describe the first case in the literature of complication-free epilepsy surgery in a paediatric patient with collagen type IV alpha 1 (COL4A1) mutation. METHODS: This is a case report. RESULTS: COL4A1 mutations disrupt the integrity of vascular basement membranes, so predisposing to a broad spectrum of disorders including periventricular leucomalacia, haemorrhagic stroke, aneurysm formation, epilepsy and developmental delay. Intracranial haemorrhage is reported and may be recurrent or associated with trauma and anticoagulant therapy...
August 2014: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/24850312/neonatal-monocytes-express-antiapoptotic-pattern-of-bcl-2-proteins-and-show-diminished-apoptosis-upon-infection-with-escherichia-coli
#16
Anja Leiber, Benjamin Graf, Bärbel Spring, Justine Rudner, Natascha Köstlin, Thorsten W Orlikowsky, Christian F Poets, Christian Gille
BACKGROUND: Neonates show sustained inflammation after a bacterial infection, which is associated with inflammatory diseases like bronchopulmonary dysplasia or periventricular leucomalacia. Physiologically, inflammation is terminated early after the removal of the invading pathogens by phagocytosis-induced cell death (PICD) of immune effector cells. Earlier results showed reduced PICD in neonatal monocytes. The underlying molecular mechanisms are unknown. We hypothesize that the reduced PICD in neonatal monocytes is regulated through the proteins of the B-cell lymphoma 2 (Bcl-2) protein family...
August 2014: Pediatric Research
https://www.readbyqxmd.com/read/24708702/midtrimester-preterm-prelabour-rupture-of-membranes-pprom-expectant-management-or-amnioinfusion-for-improving-perinatal-outcomes-ppromexil-iii-trial
#17
RANDOMIZED CONTROLLED TRIAL
Augustinus S P van Teeffelen, David P van der Ham, Christine Willekes, Salwan Al Nasiry, Jan G Nijhuis, Sander van Kuijk, Ewoud Schuyt, Twan L M Mulder, Maureen T M Franssen, Dick Oepkes, Fenna A R Jansen, Mallory D Woiski, Mireille N Bekker, Caroline J Bax, Martina M Porath, Monique W M de Laat, Ben W Mol, Eva Pajkrt
BACKGROUND: Babies born after midtrimester preterm prelabour rupture of membranes (PPROM) are at risk to develop neonatal pulmonary hypoplasia. Perinatal mortality and morbidity after this complication is high. Oligohydramnios in the midtrimester following PPROM is considered to cause a delay in lung development. Repeated transabdominal amnioinfusion with the objective to alleviate oligohydramnios might prevent this complication and might improve neonatal outcome. METHODS/DESIGN: Women with PPROM and persisting oligohydramnios between 16 and 24 weeks gestational age will be asked to participate in a multi-centre randomised controlled trial...
April 4, 2014: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/24703518/altered-microstructural-connectivity-of-the-superior-and-middle-cerebellar-peduncles-are-related-to-motor-dysfunction-in-children-with-diffuse-periventricular-leucomalacia-born-preterm-a-dti-tractography-study
#18
Shanshan Wang, Guo Guang Fan, Ke Xu, Ci Wang
PURPOSE: To investigate the microstructural integrity of superior cerebellar peduncles (SCP) and middle cerebellar peduncles (MCP) by using DTI tractography method, and further to detect whether the microstructural integrity of these major cerebellar pathways is related to motor function in children with diffuse periventricular leucomalacia (PVL) born preterm. MATERIALS AND METHODS: 46 children with diffuse PVL (30 males and 16 females; age range 3-48 months; mean age 22...
June 2014: European Journal of Radiology
https://www.readbyqxmd.com/read/24680746/improvement-of-human-umbilical-cord-mesenchymal-stem-cell-transplantation-on-glial-cell-and-behavioral-function-in-a-neonatal-model-of-periventricular-white-matter-damage
#19
Li-Hua Zhu, Xiang Bai, Ning Zhang, Shi-Yu Wang, Wei Li, Li Jiang
Periventricular white matter damage (PWMD) also termed periventricular leucomalacia in the preterm infant is of particular importance because no targeted therapy is presently available. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been studied in a variety of adult brain injury-related neurological disorders. Our aim was to determine whether hUC-MSC transplantation improves glial cell function in cerebral white matter and long-term behavioral function in a PWMD rat model. Rats on postnatal day (P) 3 underwent a permanent ligation of the left common carotid artery followed by 6% O2 for 4h...
May 14, 2014: Brain Research
https://www.readbyqxmd.com/read/24505969/iris-rubeosis-severe-respiratory-failure-and-retinopathy-of-prematurity-case-report
#20
Monika Modrzejewska, Urszula Kulik, Wojciech Lubiński
THE AIM: Case study reports for the first time about development of massive iris neovascular complication in course of retinopathy of prematurity related to systemic and ocular ischemic syndrome due to tracheostomy-requiring extremely severe premature respiratory failure. MATERIAL AND METHOD: Premature female, 950 grams birth weight, born from 17-year-old gravida 1, at 28 weeks' gestation by cesarean section due to premature placental abruption with threatening hemorrhages, with 1 to 5 Apgar score...
January 2014: Ginekologia Polska
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