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Patent Ductus Arteriosus In Preterm

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https://www.readbyqxmd.com/read/30505242/diagnosis-and-management-of-patent-ductus-arteriosus
#1
Maria Gillam-Krakauer, Jeff Reese
Preterm infants are at increased risk for patent ductus arteriosus (PDA). Prolonged exposure to PDA may be deleterious and has been associated with neonatal morbidity and mortality. Although the molecular mechanisms underlying regulation of postnatal ductus arteriosus closure are not fully understood, clinical experience and research trials have informed recent changes in PDA management strategies and refocused treatment strategies on smaller subsets of infants who require intervention. This review examines current diagnostic and management approaches to PDA in preterm neonates...
July 2018: NeoReviews
https://www.readbyqxmd.com/read/30502314/health-physical-growth-and-neurodevelopmental-outcomes-in-preterm-infants-of-women-with-hypertensive-disorders-of-pregnancy
#2
Forgive Avorgbedor, Susan Silva, Elizabeth Merwin, James A Blumenthal, Diane Holditch-Davis
OBJECTIVE: To compare the health, physical growth, and developmental outcomes in preterm infants of women with and without hypertensive disorders of pregnancy (HDP). DESIGN: Cross-sectional analysis of health outcomes; physical growth (head circumference, height, and weight) collected at birth and 2 months, corrected for prematurity; and cognitive, language, and motor skills of preterm infants of women with and without HDP. SETTING: Four NICUs in the United States...
November 28, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/30496424/impact-of-mode-of-conception-on-neonatal-and-neurodevelopmental-outcomes-in-preterm-infants
#3
Lisa Molines, Simon Nusinovici, Marie Moreau, Mathilde Remy, Pascale May-Panloup, Cyril Flamant, Jean-Christophe Roze, Patrick Van Bogaert, Pierre-Emmanuel Bouet, Géraldine Gascoin
STUDY QUESTION: Is assisted conception associated with neonatal morbidity and mortality and with neurodevelopmental impairment at 2 years of corrected age in preterm infants born before 34 weeks of gestational age? SUMMARY ANSWER: Assisted conception is not associated with an increase in neonatal morbidity and mortality and is even significantly associated with a better 2-year neurodevelopmental outcome in preterm infants. WHAT IS KNOWN ALREADY: Assisted conception appears to increase the rate of preterm births, though few studies have analysed outcomes for these preterm infants...
November 29, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30477618/-clinical-features-and-prognosis-of-bronchopulmonary-dysplasia-complicated-by-pulmonary-hypertension-in-preterm-infants
#4
Chen-Hong Wang, Li-Ping Shi, Xiao-Lu Ma, Li-Zhong DU
OBJECTIVE: To study the clinical features and prognosis of bronchopulmonary dysplasia (BPD) complicated by pulmonary hypertension (PH) in preterm infants. METHODS: A retrospective analysis was performed on the clinical data of 191 preterm infants with BPD. RESULTS: In the 191 preterm infants with BPD, 37 (19.4%), all with moderate or severe BPD, developed PH beyond 36 weeks' corrected age. The incidence rates of PH in infants with moderate and severe BPD were 5...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30468303/molecular-and-mechanical-factors-contributing-to-ductus-arteriosus-patency-and-closure
#5
REVIEW
Stacey L Crockett, Courtney D Berger, Elaine L Shelton, Jeff Reese
Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left-to-right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Despite significant advances, questions remain regarding signaling dynamics and the natural time course of ductus closure, particularly in preterm neonates...
November 23, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/30423323/clinical-outcomes-after-more-conservative-management-of-patent-ductus-arteriosus-in-preterm-infants
#6
Cristina Borràs-Novell, Ana Riverola, Victoria Aldecoa-Bilbao, Montserrat Izquierdo, Monica Domingo, Martín Iriondo
OBJECTIVE: Management of patent ductus arteriosus is still controversial. This study aimed to describe the impact of a more conservative approach on treatment rates and on main outcomes of prematurity, especially in preterm infants with <26 weeks of gestation. METHOD: Clinical charts review of infants ≤30 weeks with patent ductus arteriosus between 2009 and 2016 at two centers. In 2011, the authors changed patent ductus arteriosus management: in first period (2009-2011), patients who failed medical treatment underwent surgical closure; in second period (2012-2016), only those with cardiopulmonary compromise underwent surgical ligation...
November 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/30416014/effect-of-prophylaxis-for-early-adrenal-insufficiency-using-low-dose-hydrocortisone-in-very-preterm-infants-an-individual-patient-data-meta-analysis
#7
Michele L Shaffer, Olivier Baud, Thierry Lacaze-Masmonteil, Outi M Peltoniemi, Francesco Bonsante, Kristi L Watterberg
OBJECTIVE: To assess the effect of prophylaxis for early adrenal insufficiency using low-dose hydrocortisone on survival without bronchopulmonary dysplasia (BPD) in very preterm infants using an individual patient data meta-analysis. STUDY DESIGN: All existing randomized controlled trials testing the efficacy of the prophylaxis of early adrenal insufficiency using low-dose hydrocortisone on survival without BPD were considered for inclusion when data were available...
November 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30391947/can-functional-polymorphisms-in-vegf-and-mmp-predict-intraventricular-hemorrhage-in-extremely-preterm-newborns
#8
Pankaj Prasun, Raghav Madan, Subhash Puthuraya, Divya Subramanian, Ishita Datta, Vaneet Kalra, Ronald Thomas, David W Stockton, Senthil Sundaram, Joseph Callaghan, Michael Callaghan, Nitin Chouthai
BACKGROUND: The pathophysiology of intraventricular hemorrhage (IVH) is multifactorial. This study attempts to identify genetic and clinical factors contributing to IVH in newborns with a focus on those born ≤28 weeks of gestation. METHODS: This was a prospective study of 382 consecutive newborns admitted to the neonatal intensive care unit. DNA purification was conducted using standard methods. TaqMan SNP assays were conducted for functional polymorphisms in VEGF (RS699947, RS2010963, RS3025039, and RS1570360) and MMP2 (RS243685 and RS2285053) genes...
November 2, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/30348438/predictors-of-respiratory-improvement-1-week-after-ligation-of-patent-ductus-arteriosus-in-preterm-infants
#9
Kai-Hsiang Hsu, Pierre Wong, Ram Kumar Subramanyan, Julie Evans, Shahab Noori
OBJECTIVE: To characterize preterm infants that demonstrates respiratory improvement 7 days after ligation of a patent ductus arteriosus (PDA). STUDY DESIGN: We performed a 2-phase study of preterm infants (birthweight <1500 g between 2010 and 2016). We first did a retrospective analysis using regression modeling of ligation population. We then performed a case-control study comparing a ligation group with infants matched by gestational age, postnatal age, and preligation respiratory condition (ventilator mode, mean airway pressure [MAP], and fraction of inspired oxygen [FiO2 ])...
October 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30340932/pda-tolerate-trial-an-exploratory-randomized-controlled-trial-of-treatment-of-moderate-to-large-patent-ductus-arteriosus-at-1-week-of-age
#10
Ronald I Clyman, Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C Hassinger, Susan W Aucott, Madoka Hayashi, Anne Marie Heuchan, William A Carey, Matthew Derrick, Erika Fernandez, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize
OBJECTIVE: To compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given. STUDY DESIGN: A total of 202 neonates of <28 weeks of gestation age (mean, 25.8 ± 1.1 weeks) with moderate-to-large PDA shunts were enrolled between age 6 and 14 days (mean, 8.1 ± 2.2 days) into an exploratory randomized controlled trial...
October 16, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30318943/is-high-platelet-distribution-width-in-the-first-hours-of-life-can-predict-hemodynamically-significant-patent-ductus-arteriosus-in-preterm-newborns
#11
Gamze Demirel, Aslan Yılmaz, Binay Vatansever, Ayhan Tastekin
AIM: To determine whether there is any association between platelet indices within the first hours of life and hemodynamically significant patent ductus arteriosus (hsPDA) in preterm newborns. PATIENT AND METHODS: A total of 100 preterm infants, gestational age < 32 weeks and birth weight < 1500 grams were analyzed in the study. Complete blood counts obtained within the first 6 hours of life were evaluated for platelet parameters and compared for patent ductus arteriosus (PDA) status...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30292174/a-mystery-of-patent-ductus-arteriosus-and-serum-osmolality-in-preterm-infants
#12
Ufuk Cakir, Cuneyt Tayman
OBJECTIVE:  Patent ductus arteriosus (PDA) is an important clinical problem associated with mortality and serious morbidities. It is thought that serum osmolality may affect ductal patency. We aimed to investigate the importance of serum osmolality related to ductal patency in preterm infants. STUDY DESIGN:  Our study was conducted between January 2013 and December 2017. Premature infants, birth weight <1,500 g and gestational age <32 weeks were included in the study...
October 6, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/30287890/exploration-of-potential-biochemical-markers-for-persistence-of-patent-ductus-arteriosus-in-preterm-infants-at-22-27-weeks-gestation
#13
Karl Wilhelm Olsson, Anders Larsson, Anders Jonzon, Richard Sindelar
BACKGROUND: Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persistence of PDA, and with failure of pharmacological treatment for PDA, in extremely preterm infants. METHODS: Infants born at 22-27 weeks' gestation were included in this prospective study. Blood samples were collected on the second day of life. Fourteen biochemical markers associated with factors that may affect PDA closure were analyzed and related to persistent PDA and to the response of pharmacological treatment with ibuprofen...
September 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30273357/the-predictors-for-the-non-compliance-to-follow-up-among-very-low-birth-weight-infants-in-the-korean-neonatal-network
#14
Nam Hyo Kim, Young Ah Youn, Su Jin Cho, Jong-Hee Hwang, Ee-Kyung Kim, Ellen Ai-Rhan Kim, Soon Min Lee
The critical need to emphasize preterm infant follow-up after neonatal intensive care unit (NICU) discharge assures early identification of and intervention for neurodevelopmental disability. The aims of this study were to observe the follow-up rates in high-risk follow-up clinics, and analyze factors associated with non-compliance to follow-up among very low birth weight (VLBW) infants. The data was prospectively collected for 3063 VLBW infants between January 2013 and December 2014 from 57 Korean neonatal network (KNN) centers at a corrected age of 18-24 months...
2018: PloS One
https://www.readbyqxmd.com/read/30271352/chorioamnionitis-is-a-risk-factor-for-intraventricular-hemorrhage-in-preterm-infants-a-systematic-review-and-meta-analysis
#15
Eduardo Villamor-Martinez, Monica Fumagalli, Owais Mohammed Rahim, Sofia Passera, Giacomo Cavallaro, Pieter Degraeuwe, Fabio Mosca, Eduardo Villamor
Although chorioamnionitis (CA) is a well-known risk factor for white matter disease of prematurity, the association with intraventricular hemorrhage (IVH) is controversial and has not been yet systematically reviewed. We performed a systematic review and meta-analysis of studies exploring the association between CA and IVH. A comprehensive literature search was conducted using PubMed/MEDLINE and EMBASE, from their inception to 1 July 2017. Studies were included if they examined preterm infants and reported primary data that could be used to measure the association between exposure to CA and the presence of IVH...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30270157/prevalence-of-congenital-heart-disease-at-live-birth-in-china
#16
Qu-Ming Zhao, Fang Liu, Lin Wu, Xiao-Jing Ma, Conway Niu, Guo-Ying Huang
OBJECTIVE: To investigate the prevalence of congenital heart disease (CHD) in China based on a large prospective multicenter screening study. STUDY DESIGN: A total of 122 765 consecutive infants born at 18 hospitals throughout China between August 1, 2011, and November 30, 2012, were included. Cases of CHD were identified by echocardiography, clinical assessment, and telephone follow-up. RESULTS: The overall prevalence of CHD was 8.98 per 1000 live births (critical, 1...
September 27, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30268404/long-term-neurodevelopment-of-low-birthweight-preterm-infants-with-patent-ductus-arteriosus
#17
R Thomas Collins, Robert E Lyle, Mallikarjuna Rettiganti, Jeffrey M Gossett, James M Robbins, Patrick H Casey
OBJECTIVE: To evaluate whether the presence of patent ductus arteriosus (PDA) in preterm infants worsens long-term neurodevelopmental outcomes. STUDY DESIGN: This was a secondary observational analysis of data from 1090 preterm low-birthweight infants in the Infant Health and Development Program (IHDP), a multicenter longitudinal cohort study of outcomes assessed from 3 to 18 years of age. Multivariable analysis was adjusted for IHDP treatment group (intervention or follow-up), birth weight, maternal race, maternal education, infant sex, maternal preconception weight, Home Observation Measurement of the Environment (HOME) total score at 12 months, neonatal health index, and gestational age...
September 26, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30264852/ibuprofen-for-the-treatment-of-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-or-both-infants
#18
REVIEW
Arne Ohlsson, Rajneesh Walia, Sachin S Shah
BACKGROUND: Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects. OBJECTIVES: To determine the effectiveness and safety of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitor(s), placebo, or no intervention for closing a patent ductus arteriosus in preterm, low-birth-weight, or preterm and low-birth-weight infants...
September 28, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30243544/covariation-of-neonatal-intensive-care-unit-level-patent-ductus-arteriosus-management-and-in-neonatal-intensive-care-unit-outcomes-following-preterm-birth
#19
James I Hagadorn, Mihoko V Bennett, Elizabeth A Brownell, Kurlen S E Payton, William E Benitz, Henry C Lee
OBJECTIVE: To test the hypothesis that neonatal intensive care unit (NICU)-specific changes in patent ductus arteriosus (PDA) management are associated with changes in local outcomes in preterm infants. STUDY DESIGN: This retrospective repeated-measures study of aggregated data included infants born 400-1499 g admitted within 2 days of delivery to NICUs participating in the California Perinatal Quality Care Collaborative. The period 2008-2015 was divided into four 2-year epochs...
September 20, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30227731/comparison-of-efficacy-of-oral-paracetamol-versus-ibuprofen-for-pda-closure-in-preterms-a-prospective-randomized-clinical-trial
#20
Bharathi Balachander, Nivedita Mondal, Vishnu Bhat, Bethou Adhisivam, Mahesh Kumar, Santhosh Satheesh, Mahalakshmi Thulasingam
BACKGROUND: Currently nonselective cyclooxygenase (COX) inhibitors, ibuprofen and indomethacin, are approved drugs for closure of patent ductus arteriosus but have potential toxicities. There are reports of the effectiveness of paracetamol in ductal closure. However, there is paucity of data comparing paracetamol to ibuprofen or indomethacin in relation to the efficacy and safety profile. METHODS: This randomized clinical trial was done in our tertiary care neonatal unit from October 2014 to January 2016 after clearance from ethical committee...
October 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
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