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Estrogenic Foods

Sara Grioni, Claudia Agnoli, Vittorio Krogh, Valeria Pala, Sabina Rinaldi, Marco Vinceti, Paolo Contiero, Luciano Vescovi, Marcella Malavolti, Sabina Sieri
Diet is the primary source of cadmium - a proven Group 1 human carcinogen - for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR) and HER2 status, in 8,924 women recruited to a prospective study between 1987 and 1992. Dietary cadmium intake was estimated using a semi-quantitative food frequency questionnaire at baseline...
December 4, 2018: International Journal of Cancer. Journal International du Cancer
Pao-Lin Kuo, Jie-Yun Tseng, Hau-Ing Chen, Chia-Yun Wu, Hany A Omar, Chia-Yih Wang, Han-Yi Cheng, Chao-Chin Hsu, Tzu-Fun Fu, Yen-Ni Teng
SEPTIN12 (SEPT12) is a testis-enriched gene that is downregulated in the testis of infertile men with severe spermatogenic defects. While SEPT12 is involved in spermatogenic failure and sperm motility disorder, SEPT12 transcriptional regulation is still unknown. Here we report the promoter region of SEPT12 as a 245 bp segment upstream from the transcription start site. One androgen receptor (AR) and two of estrogen receptor α (ERα) binding sites were on this region were identified initially by Bioinformatics prediction and confirmed by chromatin immunoprecipitation assay...
December 1, 2018: Biochimie
Divya Krishnamoorthy, Robert C Hoy, Devorah M Natelson, Olivia M Torre, Damien M Laudier, James C Iatridis, Svenja Illien-Jünger
Back pain is a leading cause of disability strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structure-modifying advanced glycation end-products (AGEs) contribute to obesity and diabetes, which are associated with increased back pain, and accumulate in tissues due to hyperglycemia or ingestion of foods processed at high heat. Collagen-rich IVDs are particularly susceptible to AGE accumulation due to their slow metabolic rates yet it is unclear if dietary AGEs can cross the endplates to accumulate in IVDs...
November 29, 2018: Disease Models & Mechanisms
Ginger D Constantine, Grant Kessler, Shelli Graham, Steven R Goldstein
BACKGROUND: The Surveillance, Epidemiology, and End Result (SEER) database shows a variable increase in endometrial cancer incidence over time. The objective of this review was to examine published endometrial cancer rates and potential etiologies. METHODS: Endometrial cancer incidence was obtained from the SEER Program database from 1975 through 2014, and a test for trend in incidence was calculated. Changes in risk factors thought to be associated with endometrial cancer, including age, obesity, diabetes, diet and exercise, reproductive factors, and medications (hormone therapy [HT] including Food and Drug Administration [FDA]-approved and non-FDA-approved [compounded] estrogens and progestogens, tamoxifen, and hormonal contraceptives) were found through PubMed searches...
November 28, 2018: Journal of Women's Health
L Kolatorova, M Sramkova, J Vitku, J Vcelak, O Lischkova, L Starka, M Duskova
Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was to investigate the possible connections of paraben exposure and obesity...
November 28, 2018: Physiological Research
Rebecca C Clawson, Leslie N Dela Cruz, Steven Allen, Tierney Wolgemuth, Amanda Maner, Anna Dorsett, Helen I'Anson
A large part of the daily intake of children in the U.S. consists of snacks, with the average child consuming three snacks per day. Despite this, little research has been conducted to determine the metabolic and behavioral effects of snacking. Using a developing female rat model, our studies aimed to determine the effects of snacking during development before the protective effects of estrogen on weight gain would be relevant. Additionally, to determine if snack composition is important, we created one healthy and one unhealthy snacking group provided with chow and three snacks each in addition to a chow-only group...
November 22, 2018: Physiology & Behavior
Jessica Santollo, Derek Daniels
Activation of membrane-associated estrogen receptors (mER) decreases food and water intake in female rats. Additional studies suggest these effects are mediated, at least in part, by membrane-associated estrogen receptor alpha (ERα). Nevertheless, the critical site of action and the intracellular signaling required for the ingestive effects of ERα remain unclear. Estradiol given to the medial preoptic area (mPOA) decreases ingestive behaviors, and membrane-associated ERα has been shown to affect intracellular signaling through interactions with metabotropic glutamate receptor (mGluR) subtypes, but an involvement of this signaling pathway, in the mPOA, in ingestive behavior remains untested...
November 23, 2018: Hormones and Behavior
Alexey A Tinkov, Olga P Ajsuvakova, Margarita G Skalnaya, Anatoly V Skalny, Michael Aschner, Joanna Suliburska, Jan Aaseth
The objective of the present study was to review the mechanisms of organotin-induced adipogenesis, obesity, and associated metabolic disturbances. Peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor α (RXRα) activation is considered as the key mechanism of organotin-induced adipogenesis. Particularly, organotin exposure results in increased adipogenesis both in cell and animal models. Moreover, transgenerational inheritance of organotin-induced obese phenotype was demonstrated in vivo...
November 8, 2018: Journal of Inorganic Biochemistry
Ayelen L Gomez, Gabriela A Altamirano, Jorgelina Leturia, Verónica L Bosquiazzo, Mónica Muñoz-de-Toro, Laura Kass
Postnatal treatment with glyphosate-based herbicides (GBHs) induces endocrine-disrupting effects on the male rat mammary gland. In this study, the effects of developmental exposure to GBH on mammary gland growth and development, and the possible molecular mechanisms involved, were evaluated in pre- and post-pubertal male rats. To this end, pregnant rats were orally exposed through the food to 0, 3.5 or 350 mg GBH/kg bw/day from gestational day 9 until weaning. Mammary gland development and estradiol (E2) and testosterone (T) serum levels of male offspring were evaluated on postnatal day (PND)21 and PND60...
November 14, 2018: Molecular and Cellular Endocrinology
Youn-Hwan Hwang, Hyunil Ha, Rajeong Kim, Chang-Won Cho, Young-Ran Song, Hee-Do Hong, Taesoo Kim
Potent anti-osteoporotic drugs have been developed over the past decades; however, the substantial need for treatments that can effectively and safely manage osteoporosis remains unmet. Barley leaf-derived products are one of best functional foods that can be used as nutritional supplements and detoxifiers in humans and are beneficial in improving bone disease. However, little information is available regarding the anti-osteoporotic effects of polysaccharides as the main component of barley leaf. This study aimed to clarify the beneficial effects of barley leaf (BLE0) polysaccharides on bone loss in ovariectomized mice and osteoclast differentiation in bone marrow-derived macrophages...
November 13, 2018: International Journal of Biological Macromolecules
Yu-Shun Lin, Shui-Yuan Lu, Hai-Ping Wu, Chi-Fen Chang, Yung-Tsung Chiu, Hui-Ting Yang, Pei-Min Chao
The objective was to investigate endocrine-disrupting effects of polar compounds from oxidized frying oil. Estrogenicity of polar compounds was tested with a rat uterotrophic bioassay. Dietary oxidized frying oil (containing 51% polar compounds) or polar compounds isolated from it were incorporated into feed (in lieu of fresh soybean oil) and fed to ovariectomized rats, with or without treatment with exogenous ethynyl estradiol. Exogenous estrogen restored uterine weight, and caused histological abnormalities (stratified epithelia and conglomerate glands) as well as proliferation of uterine epithelial cells...
November 6, 2018: Ecotoxicology and Environmental Safety
Timothy J Key, Balkwill Angela, Kathryn E Bradbury, Gillian K Reeves, Ai Seon Kuan, Rachel F Simpson, Jane Green, Valerie Beral
Background: The role of diet in breast cancer aetiology is unclear; recent studies have suggested associations may differ by estrogen receptor status. Methods: Baseline diet was assessed in 2000-04 using a validated questionnaire in 691 571 postmenopausal UK women without previous cancer, who had not changed their diet recently. They were followed by record linkage to national cancer and death databases. Cox regression yielded adjusted relative risks for breast cancer for 10 food items and eight macronutrients, subdivided mostly into five categories of baseline intake...
November 8, 2018: International Journal of Epidemiology
Mariko Nakata, Anders Ågmo, Shoko Sagoshi, Sonoko Ogawa
Acquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, i.e., 17β-estradiol, but precise role played by ER β (ERβ) is still unclear. In the present study, we investigated effects of ERβ gene disruption on social rank establishment in male mice...
2018: Frontiers in Behavioral Neuroscience
Qianqian Lu, Yuying Yang, Sheng Jia, Shaoqian Zhao, Bin Gu, Peng Lu, Yang He, Rui-Xin Liu, Jiqiu Wang, Guang Ning, Qin-Yun Ma
Appetite is tightly controlled by neural and hormonal signals in animals. In general, steroid receptor co-activator 1 (SRC1) enhances steroid hormone signalling in energy balance and serves as a common co-activator of several steroid receptors, such as estrogen and glucocorticoid receptors. However, the key roles of SRC1 in energy balance remain largely unknown. We first confirmed that SRC1 is abundantly expressed in the hypothalamic arcuate nucleus (ARC), which is a critical centre for regulating feeding and energy balance; it is further co-localised with agouti-related protein and proopiomelanocortin neurons in the arcuate nucleus...
October 1, 2018: Journal of Molecular Endocrinology
Virginia Lorenz, María M Milesi, Marlise Guerrero Schimpf, Enrique H Luque, Jorgelina Varayoud
Previously, we have shown that perinatal exposure to a glyphosate-based herbicide (GBH) induces implantation failures in rats. Estrogen receptor alpha (ERα) is critical for successful implantation. ERα transcription is under the control of five promoters (E1, OT, O, ON, and OS), which yield different transcripts. Here, we studied whether perinatal exposure to a GBH alters uterine ERα gene expression and prompts epigenetic modifications in its regulatory regions during the preimplantation period. Pregnant rats (F0) were orally treated with 350 mg glyphosate/kg bw/day through food from gestational day (GD) 9 until weaning...
November 2, 2018: Molecular and Cellular Endocrinology
Hyesoo Jeong, Soolin Kim, Mi-Yeon Kim, Jimin Lee, Byoung Ha An, Hee-Doo Kim, Hyunyoung Jeong, Yun Seon Song, Minsun Chang
Opuntia ficus indica (OFI) is grown abundantly in arid areas and its fruits are regarded as an important food and nutrient source owing to the presence of flavonoids, minerals, and proteins. The previous report that OFI exerts phytoestrogenic activity makes it plausible for OFI-containing supplements to be used as alternative estrogen replacement therapy. In the case of polypharmacy with the consumption of OFI-containing botanicals in post- or peri-menopausal women, it is critical to determine the potential drug-OFI interaction due to the modulation of drug metabolism...
October 30, 2018: International Journal of Molecular Sciences
Vicky C Chang, Michelle Cotterchio, Beatrice A Boucher, David J A Jenkins, Lucia Mirea, Susan E McCann, Lilian U Thompson
Lignan intake, and its richest food source, flaxseed, have been associated with reduced breast cancer risk. Endogenous sex hormones, such as estrogens, play a role in breast cancer development, and lignans may alter these sex hormone levels. To assess the effect of flaxseed on circulating sex hormones, a randomized controlled trial was conducted among 99 postmenopausal women in Toronto, Canada. The intervention arm consumed 2 tablespoons (15 g) of ground flaxseed daily for 7 weeks; the control arm maintained usual diet...
October 30, 2018: Nutrition and Cancer
Bruno Garcia Montagnini, Karine Vandressa Pernoncine, Lorena Ireno Borges, Nathalia Orlandini Costa, Estefânia Gastadello Moreira, Janete Aparecida Anselmo-Franci, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin
Triclosan (TCS) is a phenolic compound with antimicrobial action widely used in cosmetics and other personal care products and other industry segments. Its widespread use over the decades has made TCS one of the most commonly detected compounds in wastewater and effluent worldwide already being found in human urine, plasma and milk. In this study, the (anti)estrogenicity of TCS was evaluated in the uterotrophic assay in 18-day old female Wistar rats. In a second protocol, female rats were evaluated for the reproductive effects of TCS in a two-generation reproduction toxicity study...
December 1, 2018: Toxicology
Todd L Stincic, Pasha Grachev, Martha A Bosch, Oline K Rønnekleiv, Martin J Kelly
Energy balance is regulated by anorexigenic proopiomelanocortin (POMC) and orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons of the hypothalamic arcuate nucleus. POMC neurons make extensive projections and are thought to release both amino acid and peptide neurotransmitters. However, whether they communicate directly with NPY/AgRP neurons is debated. Initially, using single-cell RT-PCR, we determined that mouse POMCeGFP neurons express Slc17a6 ( Vglut2 ) and Slc18a2 ( Vmat2 ), but not Slc31a1 ( Vgat ) mRNA, suggesting glutamate and non-canonical GABA release...
July 2018: ENeuro
Jingjing Wang, Mengmeng Li, Wei Zhang, Aixin Gu, Jiawen Dong, Jianping Li, Anshan Shan
Zearalenone (ZEN), a nonsteroidal estrogen mycotoxin, is widely found in feed and foodstuffs. Intestinal cells may become the primary target of toxin attack after ingesting food containing ZEN. Porcine small intestinal epithelial (SIEC02) cells were selected to assess the effect of ZEN exposure on the intestine. Cells were exposed to ZEN (20 µg/mL) or pretreated with (81, 162, and 324 µg/mL) N-acetylcysteine (NAC) prior to ZEN treatment. Results indicated that the activities of glutathione peroxidase (Gpx) and glutathione reductase (GR) were reduced by ZEN, which induced reactive oxygen species (ROS) and malondialdehyde (MDA) production...
October 9, 2018: Toxins
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