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Estrogenic Foods

Bruno Garcia Montagnini, Karine Vandressa Pernoncine, Lorena Ireno Borges, Nathalia Orlandini Costa, Estefânia Gastadello Moreira, Janete Aparecida Anselmo-Franci, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin
Triclosan (TCS) is a phenolic compound with antimicrobial action widely used in cosmetics and other personal care products and other industry segments. Its widespread use over the decades has made TCS one of the most commonly detected compounds in wastewater and effluent worldwide already being found in human urine, plasma and milk. In this study, the (anti)estrogenicity of TCS was evaluated in the uterotrophic assay in 18-day old female Wistar rats. In a second protocol, female rats were evaluated for the reproductive effects of TCS in a two-generation reproduction toxicity study...
October 12, 2018: Toxicology
Todd L Stincic, Pasha Grachev, Martha A Bosch, Oline K Rønnekleiv, Martin J Kelly
Energy balance is regulated by anorexigenic proopiomelanocortin (POMC) and orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons of the hypothalamic arcuate nucleus. POMC neurons make extensive projections and are thought to release both amino acid and peptide neurotransmitters. However, whether they communicate directly with NPY/AgRP neurons is debated. Initially, using single-cell RT-PCR, we determined that mouse POMCeGFP neurons express Slc17a6 ( Vglut2 ) and Slc18a2 ( Vmat2 ), but not Slc31a1 ( Vgat ) mRNA, suggesting glutamate and non-canonical GABA release...
July 2018: ENeuro
Jingjing Wang, Mengmeng Li, Wei Zhang, Aixin Gu, Jiawen Dong, Jianping Li, Anshan Shan
Zearalenone (ZEN), a nonsteroidal estrogen mycotoxin, is widely found in feed and foodstuffs. Intestinal cells may become the primary target of toxin attack after ingesting food containing ZEN. Porcine small intestinal epithelial (SIEC02) cells were selected to assess the effect of ZEN exposure on the intestine. Cells were exposed to ZEN (20 µg/mL) or pretreated with (81, 162, and 324 µg/mL) N-acetylcysteine (NAC) prior to ZEN treatment. Results indicated that the activities of glutathione peroxidase (Gpx) and glutathione reductase (GR) were reduced by ZEN, which induced reactive oxygen species (ROS) and malondialdehyde (MDA) production...
October 9, 2018: Toxins
Sung-Hee Cho, Han-Na Song
RATIONAL: Parabens, the alkyl esters of 4-hydroxybenzoic acid, are a family of compounds widely used as preservatives in cosmetic products, including for children, and some are permitted in foods. Parabens are known to be weak endocrine disruptor because they interfere with the function of endogenous hormones through binding to estrogen receptors. Therefore, the levels of parabens in biological samples indicate endocrine disruptive exposure. In particular, hair samples can provide information on accumulated exposure to parabens...
October 5, 2018: Rapid Communications in Mass Spectrometry: RCM
Young Ho Lee, Hyun Yang, Sang R Lee, Sun Woo Kwon, Eui-Ju Hong, Hye Won Lee
Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion ( Allium fistulosum ) is well-known in Asian countries for its usage in food ingredients and traditional medicines. It is also studied for its many effects. These include activation of immune responses, antihypertensive effects, and antioxidant effects...
October 4, 2018: Nutrients
Yukitomo Arao, Katherine J Hamilton, Sydney L Lierz, Kenneth S Korach
OBJECTIVE: Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activity is regulated by estrogenic compounds. ERα consists of two transcriptional activation domains, AF-1 and AF-2. The activities of these domains are regulated through different mechanisms; however, the specific physiological role in metabolic regulation by these domains is still unclear...
September 20, 2018: Molecular Metabolism
Ying Peng, Kaleigh H Nicastro, Thomas H Epps Iii, Changqing Wu
Alternatives to Bisphenol A (BPA), such as lignin-inspired bisguaiacol F (BGF), are of interest for food contact materials due to increasing evidence of estrogenic activity (EA) and exposure-correlated harmful effects of BPA and its analogues. BGF has similar thermal and mechanical properties to BPA, but contains additional methoxy substituents that may significantly reduce its endocrine disruption potential. In this study, the EA of four BGF samples with different regioisomer ratios was quantified relative to 17-estradiol at ten concentrations by using two in vitro assays: MCF-7 cell proliferation and VM7Luc4E2 transactivation (TA)...
October 4, 2018: Journal of Agricultural and Food Chemistry
Melanie K Miller, Joshua R Smith, Jacqueline J Norman, Anita H Clayton
Female sexual dysfunction (FSD) is a highly prevalent, yet commonly underdiagnosed and undertreated condition. This paper reviews the diagnostic terminology for FSD, and basic sexual physiology in women. The Food and Drug Administration (FDA) approved drugs for FSD are discussed, followed by investigational drugs for FSD currently in phase 2 or 3 clinical trials, reasons for failure of drug development, and potential future drug targets. Areas Covered: A literature review was conducted for available treatments for FSD: flibanserin, estrogen, ospemifene and prasterone...
September 25, 2018: Expert Opinion on Emerging Drugs
F H Comhaire, W Vandenberghe, Wae Decleer
Fertility of both men and women has been negatively influenced by external factors and life style in recent decennia. Mechanisms of hormone disruption, oxidative damage, and epigenetic DNA changes play a pivotal role in this process. In Belgium, strict regulations have been imposed to reduce the exposure to xeno-estrogens, which has resulted in a partial recovery of sperm quality. At the other hand, more couples require in vitro fertilisation (IVF) whereby ovarian stimulation may be associated with epigenetic DNA hyper-methylation of follicular cells, and increased risk of carcinogenesis among offspring...
December 2017: Facts, Views & Vision in ObGyn
Jessica Audrey Feijó Corrêa, Paloma Bianca Orso, Keliani Bordin, Raquel Vaz Hara, Fernando Bittencourt Luciano
Fusarium is a fungal genus spread worldwide commonly associated to the production of several mycotoxins, where fumonisins (FBs) are of major importance due to its prevalence. Since mycotoxins have been reported to cause deleterious effects on mammalians, including carcinogenic, neurotoxic, estrogenic, and immune-suppressive, many countries had established regulations on the tolerated concentrations of such substances in foods and animal feed. Even though many mycotoxins - especially fusariotoxins - are concomitantly found in a single matrix, there is no regulation on co-occurrence levels...
September 21, 2018: Food and Chemical Toxicology
Dawn Lemanne, Victoria Maizes
A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. Practitioners knowledgeable about the evidence base behind common integrative approaches can help patients attain improved quality of life, and at times, improved survival. Evidence-based recommendations include the following: a plant-based diet for general health after diagnosis, and carbohydrate restriction for patients with estrogen receptor-positive postmenopausal breast cancer may be prudent...
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Yong-Moon Mark Park, Susan E Steck, Teresa T Fung, Anwar T Merchant, M Elizabeth Hodgson, Jean A Keller, Dale P Sandler
Dietary factors that contribute to chronic low-grade metabolic acidosis have been linked to breast cancer risk, but to date no epidemiologic study has examined diet-dependent acid load and breast cancer. We used data from 43,570 Sister Study participants who completed a validated food frequency questionnaire at enrollment (2003-2009) and satisfied eligibility criteria. The Potential Renal Acid Load (PRAL) score was used to estimate diet-dependent acid load. Higher scores reflect greater consumption of protein and phosphorus, and lower consumption of potassium, calcium, and magnesium...
September 24, 2018: International Journal of Cancer. Journal International du Cancer
Isabelle Côté, Sara M Green, Joshua F Yarrow, Christine F Conover, Hale Z Toklu, Drake Morgan, Christy S Carter, Nihal Tümer, Philip J Scarpace
We recently showed that male compared to female rats exhibit lower hypophagia and body weight (BW) loss following central leptin delivery, suggesting a role for estradiol in leptin responsiveness. Addressing this, we delivered Ob (Leptin) or GFP (Control) gene into the brain of male rats that were simultaneously treated with estradiol or Vehicle. In a reciprocal approach, we compared estradiol-deficient (Ovx) to intact females (Sham) that received Leptin or Control vector. Changes in food intake (FI), BW, and body composition were examined...
September 23, 2018: Journal of Neuroendocrinology
Mark A Guinter, Dale P Sandler, Alexander C McLain, Anwar T Merchant, Susan E Steck
Background: The results of previous studies on diet and postmenopausal breast cancer risk have been inconclusive, but there is some evidence that dietary patterns developed to correlate with estrogen levels are associated with breast cancer. We aimed to examine the association of a previously developed estrogen-related dietary pattern (ERDP) with postmenopausal breast cancer in the Sister Study. Methods: The ERDP was calculated from food frequency questionnaire responses among Sister Study participants without a personal history of cancer and who contributed postmenopausal person-time at risk...
October 2018: Cancer Epidemiology, Biomarkers & Prevention
Mark D Pegram, Yu Zong, Clinton Yam, Matthew P Goetz, Stacy L Moulder
Metastatic breast cancer continues to be a life-threatening diagnosis that impacts hundreds of thousands of patients around the world. Targeted therapies are usually associated with less toxicity compared with cytotoxic chemotherapies and often induce response or durable disease control in estrogen receptor (ER) and/or HER2+ breast cancers. Drugs that target CDK 4/6 either alone or in combination with endocrine therapy have demonstrated substantial improvements in progression-free survival (PFS) compared with endocrine monotherapy...
May 23, 2018: American Society of Clinical Oncology Educational Book
Lisa L Koorneef, Marit Bogaards, Marcel J T Reinders, Onno C Meijer, Ahmed Mahfouz
Metabolic status impacts on the emotional brain to induce behavior that maintains energy balance. While hunger suppresses the fear circuitry to promote explorative food-seeking behavior, satiety or obesity may increase fear to prevent unnecessary risk-taking. Here we aimed to unravel which metabolic factors, that transfer information about the acute and the chronic metabolic status, are of primary importance to regulate fear, and to identify their sites of action within fear-related brain regions. We performed a de novo analysis of central and peripheral metabolic factors that can penetrate the blood-brain barrier using genome-wide expression data across the mouse brain from the Allen Brain Atlas (ABA)...
2018: Frontiers in Neuroscience
Ángela Peirotén, Pilar Gaya, Inmaculada Álvarez, Daniel Bravo, José Mª Landete
Enterolignans, i.e. enterodiol and enterolactone, are polyphenols derived from the microbial metabolism of dietary lignans. They are considered phytoestrogens because of their estrogenic/antiestrogenic activity, which confers them benefits to human health when they reach sufficient levels in plasma. Hence, there is a great interest in studying the bacteria involved in enterolignan production. In the present study, three bifidobacterial strains (Bifidobacterium bifidum INIA P466, Bifidobacterium catenulatum INIA P732 and Bifidobacterium pseudolongum INIA P2) were found capable of producing low levels of enterodiol (2-11 μM) from lignan extracts; while another one (Bifidobacterium pseudocatenulatum INIA P946) was found to produce an important increment of the lignan secoisolariciresinol (SECO)...
August 30, 2018: International Journal of Food Microbiology
Manuela Cipolletti, Virginia Solar Fernandez, Emiliano Montalesi, Maria Marino, Marco Fiocchetti
The potential "health benefits" of dietary polyphenols have been ascribed to their direct antioxidant activity and their impact on the regulation of cell and tissue redox balance. However, because of the relative poor bioavailability of many of these compounds, their effects could not be easily explained by the antioxidant action, which may occur only at high circulating and tissue concentrations. Therefore, many efforts have been put forward to clarify the molecular mechanisms underlining the biological effect of polyphenols in physiological and pathological conditions...
September 5, 2018: International Journal of Molecular Sciences
Claudia Busonero, Stefano Leone, Fabrizio Bianchi, Filippo Acconcia
PURPOSE: Most breast cancers (BCs) express estrogen receptor α (ERα) and are treated with the endocrine therapy (ET) drugs 4OH-tamoxifen (Tam) and fulvestrant (ICI 182,780; ICI). Unfortunately, a high fraction of ET treated women relapses and becomes resistant to ET. Therefore, additional anti-BC drugs are needed. Recently, we proposed that the identification of novel anti-BC drugs can be achieved using modulation of the intracellular ERα content in BC cells as a pharmacological target...
September 4, 2018: Cellular Oncology (Dordrecht)
Luca Dellafiora, Georg Aichinger, Elena Geib, Leyre Sánchez-Barrionuevo, Matthias Brock, David Cánovas, Chiara Dall'Asta, Doris Marko
Many small molecules of food origin may effect human health but lack an adequate description of their biological activity. To fill this knowledge gap, a first-line workflow is needed to assign putative functions, rank the endpoints for testing and guide wet-lab experiments. In this framework, the identification of potential biological targets can be used to probe the activity of orphan compounds using a so-called "target fishing" approach. Here, we present a proof of concept study using an in silico/in vitro target fishing approach on the fungal secondary metabolite atromentin...
January 1, 2019: Food Chemistry
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