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Glycemic control for diabetes patient

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https://www.readbyqxmd.com/read/30543519/commutable-whole-blood-reference-materials-for-hemoglobin-a1c-validated-on-multiple-clinical-analyzers
#1
Hong Liu, Lingkai Wong, Sharon Yong, Qinde Liu, Tang Lin Teo, Tong Kooi Lee, Tze Ping Loh, Sunil Kumar Sethi, Moh Sim Wong, Shelia Marie Delos Santos Cosio, Clement K M Ho, Johnson Weng Sung Setoh, Sok Fong Maria Lim, Grace Lay Lay Lee, Hafash Khalid, Sharine Lim, Choong-Weng Lam, Mee-Yin Lee, Chin Pin Yeo, Pallavi Ravikiran Chincholkar, Robert Hawkins, Bih-Yann Ng
Background The measurement of hemoglobin A1c (HbA1c) is important for diagnosing diabetes mellitus as well as assessing glycemic control in diabetic patients. Commutable whole blood certified reference materials (CRMs) are needed in the measurement of HbA1c for method validation and/or as quality controls. Methods We developed three levels of hemolyzed whole blood CRMs for HbA1c. The certified values were determined using liquid chromatography-isotope dilution tandem mass spectrometry method (LC-IDMS/MS) where two "signature" hexapeptides of HbA1c and hemoglobin A0 (HbA0) were used as the calibration standards...
December 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30541218/-glycemic-control-and-its-associated-factors-in-children-and-adolescents-with-type-1-diabetes-mellitus
#2
P Ling, Y Zhang, S H Luo, X Y Zheng, L L Qiu, D Z Yang, H Y Ai, J Lü, F Y Yuan, X W Zhang, W Xu, H Liang, J H Yan, B Yao, J P Weng
Objective: To explore the factors associated with glycemic control in children and adolescents with type 1 diabetes mellitus (T1DM) treated with continuous subcutaneous insulin infusion (CSII). Methods: Subjects were enrolled from the Guangdong Type 1 Diabetes Translational Medicine Study between June 2011 and August 2017. Patients with T1DM aged less than 18 years and treated with CSII for at least 6 months were included. Demographic data and clinical information on self-monitoring of blood glucose (SMBG), glycosylated hemoglobin (HbA1c) and insulin treatment were collected...
December 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/30541144/pancreatic-islet-transplantation-in-humans-recent-progress-and-future-directions
#3
Michael R Rickels, R Paul Robertson
Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved...
December 12, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/30540003/consumption-of-dietary-intake-markers-by-patients-with-diabetes-assessed-using-a-mobile-application
#4
Maria Cristina Zanchim, Vanessa Ramos Kirsten, Ana Carolina Bertoletti De Marchi
The aim of this study was to assess the consumption of dietary intake markers in patients with diabetes using a mobile application. A cross-sectional study was conducted with 100 younger and older adult type 2 diabetes patients in treatment in a hospital in the State of Rio Grande do Sul, Brazil. Data was collected using the Diabetes Food Control app. The chi-squared test was used to measure the association between adequate consumption of healthy and unhealthy markers and the variables investigated by the study adopting a 5% significance level...
December 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/30539524/impact-of-duodeno-jejunal-bypass-liner-endobarriertm-implantation-on-insulin-sensitivity-in-patients-with-type-2-diabetes-mellitus-t2dm-a-study-protocol-for-a-pilot-trial
#5
Norbert Joachim Tripolt, Felix Aberer, Jasmin Url, Christoph Högenauer, Florian Schreiber, Andreas Eherer, Caren Sourij, Anna-Maria Obermayer, Vanessa Stadlbauer, Eva Svehlikova, Martina Brunner, Harald Kojzar, Peter Nikolaus Pferschy, Thomas Rudolf Pieber, Harald Sourij
INTRODUCTION: A 60-cm endoscopically implantable duodenal-jejunal bypass liner (Endobarrier™, GI Dynamics, Lexington, MA, USA) has been introduced as a therapeutic option to support weight loss for a selected group of obese subjects with type 2 diabetes mellitus (T2DM). The sleeve prevents contact between chyme and the intestinal mucosa of the upper gastrointestinal tract. The primary aim of this study is to elucidate the changes in insulin sensitivity and beta-cell function after EndoBarrier™ implantation in obese patients with T2DM; changes in gut permeability and gut microbiome are also to be examined...
December 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30539523/a-review-of-the-safety-and-adverse-event-profile-of-the-fixed-ratio-combination-of-insulin-glargine-and-lixisenatide
#6
REVIEW
Juan P Frias, Terry Dex, Michelle Roberts, Allen Kaplan
INTRODUCTION: iGlarLixi is a titratable, fixed-ratio combination of insulin glargine (100 units/mL) and lixisenatide (33 μg/mL). This review evaluates the overall safety and adverse event (AE) profile of iGlarLixi in patients with type 2 diabetes. METHODS: We collated patient-level data from the phase 2 LixiLan proof-of-concept trial and the phase 3 LixiLan-L (insulin-experienced patients) and LixiLan-O (insulin-naïve patients) trials to evaluate AEs associated with iGlarLixi...
December 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30538430/effectiveness-of-pharmacist-led-educational-interventions-on-self-care-activities-and-glycemic-control-of-type-2-diabetes-patients-a-systematic-review-and-meta-analysis
#7
REVIEW
Allah Bukhsh, Xuan Ying Tan, Kok Gan Chan, Learn-Han Lee, Bey-Hing Goh, Tahir Mehmood Khan
Background: Effectiveness of pharmacist-led educational interventions on self-care activities and glycemic control of type 2 diabetes mellitus (T2DM) patients is vague. The purpose of this review is to appraise the effect of pharmacist-led educational interventions on self-care activities and levels of glycated hemoglobin of T2DM patients. Methods: Five electronic databases were searched from date of database inception to September 2017. Randomized clinical trials examining the effectiveness of pharmacist-led educational interventions, directed at T2DM patients only, were included for systematic review and meta-analysis...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/30537714/glp1-receptor-agonist-liraglutide-is-an-effective-therapeutic-option-for-perioperative-glycemic-control-in-type-2-diabetes-within-enhanced-recovery-after-surgery-eras-protocols
#8
Shizuka Kaneko, Youhei Ueda, Yumiko Tahara
BACKGROUND: Enhanced Recovery After Surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery after surgical procedures by maintaining preoperative organ function and reducing profound stress responses following surgery [Wilmore and Kehlet: BMJ 2001; 322(7284): 473-6]. Glucagon-like peptide-1 receptor agonists (GLP-1RAgs), such as liraglutide, have recently been widely used as antidiabetic agents in patients with type 2 diabetes (T2D) because they maintain blood glucose at an ideal level throughout the day, including during postprandial periods, thereby improving hypoglycemia and body weight more than insulin therapies...
December 11, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/30536746/ipragliflozin-an-sglt2-inhibitor-reduces-body-weight-and-fat-mass-but-not-muscle-mass-in-japanese-type-2-diabetic-patients-treated-with-insulin-a-randomized-clinical-trial
#9
Hideka Inoue, Katsutaro Morino, Satoshi Ugi, Sachiko Tanaka-Mizuno, Keiko Fuse, Itsuko Miyazawa, Keiko Kondo, Daisuke Sato, Natsuko Ohashi, Shogo Ida, Osamu Sekine, Masahiro Yoshimura, Kiyoshi Murata, Katsuyuki Miura, Hisatomi Arima, Hiroshi Maegawa
AIMS/INTRODUCTION: SGLT2 inhibitors reduce body weight (BW) by creating a negative energy balance. Previous reports have suggested that this BW reduction is mainly loss of body fat and that ~20% of the reduction is lean mass. However, the effects of SGLT2 inhibitors on BW and body composition remain unclear. We examined these effects in Japanese patients with type 2 diabetes mellitus treated with insulin. MATERIALS AND METHODS: In this open-label, randomized controlled trial, 49 overweight patients (BMI ≥23 kg/m2 ) with inadequate glycemic control (HbA1c >7...
December 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30535871/sitagliptin-vs-pioglitazone-as-add-on-treatments-in-patients-with-uncontrolled-type-2-diabetes-on-the-maximal-dose-of-metformin-plus-sulfonylurea
#10
P Khaloo, S Asadi Komeleh, H Alemi, M A Mansournia, A Mohammadi, A Yadegar, M Afarideh, S Esteghamati, M Nakhjavani, A Esteghamati
AIMS: To compare the efficacy of sitagliptin versus pioglitazone as add-on drugs in patients with poorly controlled diabetes with metformin and sulfonylureas. METHODS: This is a randomized, open-label, parallel assignment clinical trial. Patients who had inadequate glycemic control [7% (53 mmol/mol) ≤ A1C < 11% (97 mmol/mol)] despite a minimum 6-month period of active treatment with metformin 2000 mg/day plus gliclazide 240 mg/day were enrolled in the study...
December 10, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30535534/the-effects-of-probiotic-supplementation-on-genetic-and-metabolic-profiles-in-patients-with-gestational-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#11
Mahtab Babadi, Ahmad Khorshidi, Esmat Aghadavood, Mansooreh Samimi, Elham Kavossian, Fereshteh Bahmani, Alireza Mafi, Rana Shafabakhsh, Mahbobeh Satari, Zatollah Asemi
This study was carried out to evaluate the effects of probiotic supplementation on genetic and metabolic profiles in patients with gestational diabetes mellitus (GDM) who were not on oral hypoglycemic agents. This randomized, double-blind, placebo-controlled clinical trial was conducted in 48 patients with GDM. Participants were randomly divided into two groups to intake either probiotic capsule containing Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium bifidum, Lactobacillus fermentum (2 × 109  CFU/g each) (n = 24) or placebo (n = 24) for 6 weeks...
December 8, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/30534206/antidiabetic-efficacy-of-lactoferrin-in-type-2-diabetic-pediatrics-controlling-impact-on-ppar-%C3%AE-sirt-1-and-tlr4-downstream-signaling-pathway
#12
Waleed A Mohamed, Mona F Schaalan
The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric population. Sixty young obese patients with type 2 diabetes were selected from the Pediatric Endocrine Metabolic Unit, Cairo University and were randomly divided among two age and sex-matched groups so as to receive either standard therapy without lactoferrin in one arm or to be treated with oral lactoferrin capsules (250 mg/day, p...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/30532096/type-2-diabetes-mellitus-is-associated-with-carotid-artery-plaques-in-patients-with-premature-coronary-heart-disease
#13
J Gabriel Juárez-Rojas, Carlos Posadas-Romero, Rocío Martínez-Alvarado, Esteban Jorge-Galarza, Juan Reyes-Barrera, L Gabriela Sánchez-Lozada, Margarita Torres-Tamayo, Aida X Medina-Urrutia
Background: In subjects without a history of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) is associated with carotid artery plaques (CAP), which is a better marker than high carotid intima-media thickness (hCIMT) for predicting first or recurrent cardiovascular events. Objective: The objective of this study is to analyze the association of T2DM with CAP and hCIMT in premature CHD patients. Methods: Premature CHD was considered before the age of 55 years in men and before 65 in women...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/30529824/a-novel-analytical-approach-towards-in-vitro-bile-acid-binding-studies-to-colesevelam-hydrochloride-tablets-an-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometric-method
#14
Sunny Raina, Ashish Mungantiwar, Supriya Halde, Nancy Pandita
Colesevelam hydrochloride is a bile acid sequestrant used as a low density lipoprotein (LDL) reducing agent in hyperlipidemia with an additional advantage to improve glycemic control in type 2 diabetes patients. The objective of the study was to develop and validate a liquid chromatography tandem mass spectroscopic method for the simultaneous in-vitro estimation of bile acid salts of Glycocholic acid (GC), Glycochenodeoxycholic acid (GCDC) and Taurodeoxycholic acid (TDC) and its application in performing in-vitro binding study with Colesevelam Hydrochloride tablets...
November 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30528729/advances-in-transdermal-insulin-delivery
#15
REVIEW
Yuqi Zhang, Jicheng Yu, Anna R Kahkoska, Jinqiang Wang, John B Buse, Zhen Gu
Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years...
December 7, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30526578/perioperative-management-in-a-patient-with-type-1-diabetes-mellitus-who-presented-severe-hypoglycemia-during-dental-implant-surgery-a-case-report
#16
Hajime Shimoda, Tetsu Takahashi
BACKGROUND: Patients with type 1 diabetes mellitus (DM) have poor glycemic control owing to extreme impairments in glucose tolerance. There are few reports regarding dental implant surgery in patients with type 1 DM. We describe herein the perioperative glycemic management in an outpatient with type 1 DM who experienced a rare case of severe hypoglycemia during dental implant surgery. Only one such case has previously been reported. CASE PRESENTATION: A 60-year-old male patient diagnosed with type 1 DM was scheduled for dental implant primary surgery...
December 7, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/30526503/early-onset-of-graft-glomerulopathy-in-a-patient-with-post-transplant-diabetes-mellitus-after-renal-transplantation-a-case-report
#17
Marilena Gregorini, Vincenzo Sepe, Francesca Eleonora Pattonieri, Anna Allesina, Teresa Rampino
BACKGROUND: Post-transplant diabetes mellitus (PTDM) is an emerging problem in kidney transplantation, representing an important risk factor for kidney function loss. Diabetic nephropathy (DN) occurrence in transplanted kidneys is poorly investigated. Current knowledge describes DN recurrence in graft 5.9 years from kidney transplantation however there is little data about PTDM and DN. Here, we report a clinical case peculiar for an early appearance of advanced glomerular diabetic lesions, after kidney transplantation...
December 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30523035/cost-effectiveness-analysis-of-routine-screening-using-massively-parallel-sequencing-for-maturity-onset-diabetes-of-the-young-in-a-pediatric-diabetes-cohort-reduced-health-system-costs-and-improved-patient-quality-of-life
#18
Stephanie R Johnson, Hannah E Carter, Paul Leo, Samantha A Hollingworth, Elizabeth A Davis, Timothy W Jones, Louise S Conwell, Mark Harris, Matthew A Brown, Nicholas Graves, Emma L Duncan
OBJECTIVE: Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of diabetes, with multiple causative genes. Some MODY subtypes can be treated with sulfonylureas instead of insulin, improving glycemic control, complication rates, quality of life (QoL), and costs. Using massively parallel sequencing (MPS), we recently determined the prevalence of pathogenic/likely pathogenic MODY variants in an Australian pediatric diabetes cohort. Here, these data are used to estimate cost-effectiveness of using MPS for MODY in all pediatric diabetes cases compared with standard practice (sequencing limited to individuals with specific clinical features)...
December 6, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30517078/status-and-trends-in-the-use-of-insulin-analogs-insulin-delivery-systems-and-their-association-with-glycemic-control-comparison-of-the-two-consecutive-recent-cohorts-of-japanese-children-and-adolescents-with-type-1-diabetes-mellitus
#19
Yukiyo Yamamoto, Toru Kikuchi, Tatsuhiko Urakami, Motohide Goto, Kohji Tsubouchi, Goro Sasaki, Haruo Mizuno, Yuki Abe, Kazuteru Kitsuda, Shin Amemiya, Shigetaka Sugihara
Background Treatment for type 1 diabetes mellitus (T1DM) has greatly changed by the general use of insulin analogs and continuous subcutaneous insulin infusion (CSII). To investigate whether these advances have been translated into continued improvement in glycemic control in Japanese children and adolescents, we analyzed the registration data of the two consecutive recent cohorts of Japanese childhood-onset T1DM patients. Methods The registration data including hemoglobin A1c (HbA1c), hypoglycemia and insulin regimen were compared between the two cohorts (862 patients in the 2008 cohort and 1090 in the 2013 cohort)...
December 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30516068/managing-diabetes-and-preventing-heart-disease-have-we-found-a-safe-and-effective-agent
#20
Judy W M Cheng, Vincent J Colucci, James S Kalus, Sarah A Spinler
OBJECTIVE: While improving glycemic control with antihyperglycemics has been demonstrated to reduce microvascular complications, the benefits of reduction in cardiovascular diseases (CVDs) have not been demonstrated with older agents. This article reviews current evidence of the CV outcomes of newer antihyperglycemics approved since 2008. DATA SOURCES: Peer-reviewed articles were identified from MEDLINE (1966 to October 31, 2018) using search terms exenatide, liraglutide, lixisenatide, dulaglutide, semaglutide, alogliptin, linagliptin, saxagliptin, sitagliptin, canagliflozin, dapagliflozin, empagliflozin, mortality, myocardial infarction (MI), heart failure (HF), and stroke...
December 5, 2018: Annals of Pharmacotherapy
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