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Ming-Xia Zhang, Hong-Liang Xu
Generally, the hydroboration of benzonitrile produces B-N containing compounds. However, an unprecedented B-C bond may be formed in the presence of a suitable external electric field (EEF). In reactions of benzonitrile with borane, when the EEF is oriented parallel to the positive direction (N → C) of the N[triple bond, length as m-dash]C bond, the barriers to Markovnikov hydroboration are decreased gradually, meaning the pathway for generating B-C bonds becomes more favorable. Accordingly, hydroboration could be influenced and its selectivity could be controlled by changing the magnitude and direction of an applied EEF...
December 5, 2018: Physical Chemistry Chemical Physics: PCCP
Eef van der Worp, Lynette Johns, Melissa Barnett
No abstract text is available yet for this article.
December 1, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Rute J Macedo-de-Araújo, Ana Amorim-de-Sousa, António Queirós, Eef van der Worp, José M González-Méijome
PURPOSE: To compare three methods to measure center corneal clearance (CCC) during scleral lens wear: subjective (slit lamp), image processed (ImageJ) and with an optic biometer. The optic biometer technique was validated in comparison to an OCT in the first part of the study. METHODS: Twenty-two eyes (11 subjects) with healthy corneas were recruited. Three measures of OCT with scleral lens and ten measurements of axial length (AL) with IOLMaster with and without lens were performed...
November 27, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Jianjia Ma, Eef Hogervorst, Daniele Magistro, Vassilios Chouliaras, Massimiliano Zecca
Resistance bands are often used in resistance training programs for older adults. Despite their widespread use, there is a lack of objective assessment of the actual strength, speed and precision of the movements during these exercises. Therefore, this paper presents the development of a sensorised resistance-band and a preliminary trial of activities classification by using artificial intelligence. The results show that in the preliminary trial, the classification accuracy of 4 different activities reached over 96% using accelerometer data only...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Marieke De Bruyne, Levi Hoste, Delfien J Bogaert, Lien Van den Bossche, Simon J Tavernier, Eef Parthoens, Mélanie Migaud, Deborah Konopnicki, Jean Cyr Yombi, Bart N Lambrecht, Sabine van Daele, Ana Karina Alves de Medeiros, Lieve Brochez, Rudi Beyaert, Elfride De Baere, Anne Puel, Jean-Laurent Casanova, Jean-Christophe Goffard, Savvas N Savvides, Filomeen Haerynck, Jens Staal, Melissa Dullaers
Background: Inherited CARD9 deficiency constitutes a primary immunodeficiency predisposing uniquely to chronic and invasive fungal infections. Certain mutations are shown to negatively impact CARD9 protein expression and/or NF-κB activation, but the underlying biochemical mechanism remains to be fully understood. Objectives: To investigate a possible founder origin of a known CARD9 R70W mutation in five families of Turkish origin. To explore the biochemical mechanism of immunodeficiency by R70W CARD9. Methods: We performed haplotype analysis using microsatellite markers and SNPs...
2018: Frontiers in Immunology
Jiang-Ping Cun, Hong-Jie Fan, Wei Zhao, Gen-Fa Yi, Yong-Neng Jiang, Xuan-Cheng Xie
PURPOSE: We investigated the risk factors influencing MR changes associated with sacral injury from ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation for uterine fibroids. METHODS: We retrospectively analyzed a total of 346 patients with symptomatic uterine fibroids who received USgHIFU ablation. All of the patients underwent contrast-enhanced magnetic resonance imaging (CE-MRI) before and after treatment. Injury to the sacrum was set as the dependent variable, while fibroid features and the treatment parameters were set as independent variables...
November 14, 2018: International Journal of Hyperthermia
Hong-Jie Fan, Jiang-Ping Cun, Wei Zhao, Jian-Qiang Huang, Gen-Fa Yi, Rui-Hong Yao, Bu-Lang Gao, Xing-Hai Li
OBJECTIVE: To investigate factors affecting effects of ultrasound guided high intensity focused ultrasound (USgHIFU) in the treatment of single uterine fibroids (UFs) with different magnetic resonance imaging (MRI) features. METHODS: A total of 207 patients with single symptomatic UFs who were treated with HIFU were retrospectively analyzed. All UFs were grouped according to MRI features, and factors affecting HIFU ablation were set as independent variables. Non-perfusion volume ratio (NPVR) and energy efficiency factor (EEF) were set as dependent variables to establish multiple linear regression models with a stepwise method...
November 14, 2018: International Journal of Hyperthermia
Eef J Hendriks, Sander Idema, Shawn L Hervey-Jumper, Anne-Laure Bernat, Aeilko H Zwinderman, Frederik Barkhof, W Peter Vandertop, Emmanuel Mandonnet, Hugues Duffau, Mitchel S Berger, Philip C De Witt Hamer
BACKGROUND: Preoperative interpretation of resectability of diffuse nonenhancing glioma is primarily based on individual surgical expertise. OBJECTIVE: To compare the accuracy and precision between observed resections and preoperative estimates of neurosurgeons and a resection probability map (RPM). We hypothesize that the RPM estimates is as good as senior neurosurgeons. METHODS: A total of 234 consecutive patients were included from 2 centers, who had resective surgery with functional mapping between 2006 and 2012 for a supra-tentorial nonenhancing glioma...
November 10, 2018: Neurosurgery
Ross Thyer, Andrew D Ellington
One of the most remarkable, but typically unremarked, aspects of the translation apparatus is the pleiotropic pliability of tRNA. This humble cloverleaf/L-shaped molecule must implement the first genetic code, via base pairing and wobble interactions, but is also largely responsible for the specificity of the second genetic code, the pairings between amino acids, tRNA synthetases, and tRNAs. Despite the overarching similarities between tRNAs, they must nonetheless be specifically recognized by cognate tRNA synthetases and largely rejected by noncognate synthetases...
November 14, 2018: Biochemistry
Patrick C Dolder, Elizabeth B de Sousa Fernandes Perna, Natasha L Mason, Nadia R P W Hutten, Stefan W Toennes, Eef L Theunissen, Johannes G Ramaekers, Kim P C Kuypers
OBJECTIVES: 4-Fluoroamphetamine (4-FA) is a novel psychoactive substance with a pharmacological profile and reported subjective effects (e.g., empathy) intermediate between 3,4-methylenedioxymethamphetamine (MDMA) and amphetamine. Studies have shown that MDMA and amphetamine increase emotional empathy without affecting cognitive empathy; MDMA simultaneously leads to elevated levels of oxytocin, unrelated to its behavioral effects. The aim of the present study was to assess the reported enhancement of empathy by 4-FA, to assess its effects on oxytocin, and to test potential associations between both...
October 25, 2018: Human Psychopharmacology
Shi-Long Jiang, Yi-di Guan, Xi-Sha Chen, Peng Ge, Xin-Luan Wang, Yuan-Zhi Lao, Song-Shu Xiao, Yi Zhang, Jin-Ming Yang, Xiao-Jun Xu, Dong-Sheng Cao, Yan Cheng
Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number of natural products display strong antitumor activity, yet their mechanisms of action remain unclear. To gain a better understanding of how traditional Chinese medicine agents exert antitumor effects, we screened 480 natural compounds for their effects on autophagy using a high content screening assay detecting GFP-LC3 puncta in HeLa cells...
October 12, 2018: Acta Pharmacologica Sinica
Dimitri Stylemans, Sylvia Verbanck, Stefanie Vincken, Walter Vincken, Elke De Wachter, Eef Vanderhelst
BACKGROUND: While cystic fibrosis (CF) lung disease is generally considered to be an obstructive disorder, other pulmonary function patterns (PFP) may occur. Furthermore, little is known about possible associations between PFP and genotype or phenotypical characteristics. METHODS: Cross-sectional study including CF patients aged 16 years or more, identifying different PFP and exploring associations between PFP and genotype or phenotypical characteristics. RESULTS: Obstructive PFP was most prevalent in our population (n = 80), comprising obstructive lung disease (62...
October 12, 2018: Acta Clinica Belgica
K Veltman, C Harris, Y Ahmad, O Jolliet
Precise control of the glutathione/glutathione disulfide (GSH/GSSG) redox balance is vital for the developing embryo, but regulatory mechanisms are poorly understood. We developed a novel, mechanistic mass-balance model for GSH metabolism in the organogenesis stage (gestational day 10.0-11.13) rat conceptus predicting the dynamics of 8 unique metabolites in 3 conceptal compartments: the visceral yolk sac (VYS), the extra-embryonic fluid (EEF) and the embryo proper (EMB). Our results show that thiol concentrations in all compartments are well predicted by the model...
October 5, 2018: Reproductive Toxicology
Haci Ahmet Bircan, Nilgun Gurbuz, Apar Pataer, Ayse Caner, Nermin Kahraman, Emine Bayraktar, Recep Bayraktar, Mumin Alper Erdogan, Nashwa Kabil, Bulent Ozpolat
OBJECTIVES: Lung cancer is the leading cause of cancer related deaths in worldwide. Despite recent advances in treatment options, patient survival has not improved substantially due to lack of commonly expressed molecular targets and effective targeted therapeutics. Thus, better understanding of the biology of lung cancer and identification of novel therapeutic targets are urgently needed for development of highly effective molecularly targeted therapies. MATERIALS AND METHODS: Viability, proliferation and metastatic ability of lung cancer cells were evaluated using methylthiazoltetrazolium (MTT), colony formation and matrigel invasion assays, respectively...
October 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Daniela Diedrich, Katharina Stenzel, Eva Hesping, Yevgeniya Antonova-Koch, Tamirat Gebru, Sandra Duffy, Gillian Fisher, Andrea Schöler, Stephan Meister, Thomas Kurz, Vicky M Avery, Elizabeth A Winzeler, Jana Held, Katherine T Andrews, Finn K Hansen
Malaria drug discovery has shifted from a focus on targeting asexual blood stage parasites, to the development of drugs that can also target exo-erythrocytic forms and/or gametocytes in order to prevent malaria and/or parasite transmission. In this work, we aimed to develop parasite-selective histone deacetylase inhibitors (HDACi) with activity against the disease-causing asexual blood stages of Plasmodium malaria parasites as well as with causal prophylactic and/or transmission blocking properties. An optimized one-pot, multi-component protocol via a sequential Ugi four-component reaction and hydroxylaminolysis was used for the preparation of a panel of peptoid-based HDACi...
October 5, 2018: European Journal of Medicinal Chemistry
Yuan-Yuan Zhao, Ying Tian, Lin Liu, Jian-Hua Zhan, Xue Hou, Xi Chen, Ting Zhou, Yan Huang, Li Zhang
Aim: Our previous research showed that AKT inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (NPC). The purpose of the current study was to determine whether autophagy inhibition can enhance the anticancer efficacy of an AKT inhibitor (MK-2206). Materials and methods: NPC cell lines CNE-2 (Epstein-Barr virus negative) and C666-1 (Epstein-Barr virus positive) were used to conduct the research...
2018: Drug Design, Development and Therapy
Harish Jangra, Hendrik Zipse
We explored the influence of external electric fields (EEFs) on the stability of a glycine dipeptide model radical using high-level quantum chemical methods. Remotely located ions (Cl- /Na+ ) are used to implement EEF effects. The effects of these ions are reproduced using background point charges and oriented EEFs. Remote charges as far as 900 pm from the Cα radical center can be significantly stabilizing or destabilizing as a function of their relative orientation. The magnitude of these effects is also strongly dependent on the distance between the radical center and the charge location...
September 27, 2018: Journal of Physical Chemistry. B
Felipe Ten-Caten, Ricardo Z N Vêncio, Alan Péricles R Lorenzetti, Livia Soares Zaramela, Ana Carolina Santana, Tie Koide
Prokaryotic genomes show a high level of information compaction often with different molecules transcribed from the same locus. Although antisense RNAs have been relatively well studied, RNAs in the same strand, internal RNAs (intraRNAs), are still poorly understood. The question of how common is the translation of overlapping reading frames remains open. We address this question in the model archaeon Halobacterium salinarum. In the present work we used differential RNA-seq (dRNA-seq) in H. salinarum NRC-1 to locate intraRNA signals in subsets of internal transcription start sites (iTSS) and establish the open reading frames associated to them (intraORFs)...
2018: RNA Biology
Pradeep K Jatav, Ankita Sharma, Dinesh K Dahiya, Arif Khan, Atika Agarwal, S L Kothari, Sumita Kachhwaha
Finger millet [ Eleusine coracana (L.) Gaertn] is an excellent food and forage crop of arid and semiarid areas in Africa and Asia. It is well adapted to drought, heat, high salinity, poor soil fertility and low pH with an efficient C4 carbon fixation mechanism for high yield potential. To normalize the target gene expression data, the identification of suitable reference genes is essential. Ten candidate reference genes were selected and their expression stability was analyzed in various samples treated with different abiotic stress conditions...
September 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
Amol S Phule, Kalyani M Barbadikar, M S Madhav, P Senguttuvel, M B B Prasad Babu, P Ananda Kumar
A set of reference genes expressing stably under aerobic and anaerobic conditions in rice is essential to execute omics studies relating to aerobic adaptations. Stability of expression of ten rice reference genes, viz. Actin, eEF-1a, eIF-5C, Exp1, Exp2, Memp, SKP1A, TF-SUI1, TPH , and UBQ5 was validated across six experimental sets in shoot and root tissues at seedling, tillering, and panicle initiation stages. Comprehensively, Memp (Membrane protein), TPH (Tumor protein homolog), and Exp1 (Expressed protein) were revealed as the most stable set with acceptable M and V value according to the gold standards of qRT-PCR using various algorithms/tools...
September 2018: 3 Biotech
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