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https://www.readbyqxmd.com/read/30062516/comparison-of-two-methods-of-determining-lung-de-recruitment-using-the-forced-oscillation-technique
#1
K Nilsen, K Gove, F Thien, T Wilkinson, B R Thompson
Airway closure has proved to be important in a number of respiratory diseases and may be the primary functional defect in asthma. A surrogate measure of closing volume can be identified using the forced oscillation technique (FOT), by performing a deflation maneuver and examining the resultant reactance (Xrs) lung volume relationship. This study aims to determine if a slow vital capacity maneuver can be used instead of this deflation maneuver and compare it to existing more complex techniques. Three subject groups were included in the study; healthy (n = 29), asthmatic (n = 18), and COPD (n = 10) for a total of 57 subjects...
July 30, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/30022785/-usefulness-of-the-forced-oscillation-technique-in-the-diagnosis-of-cough-variant-asthma-with-prolonged-or-chronic-cough
#2
Kan Kato, Hiroshi Tanaka
BACKGROUND: Usefulness of carrying out the reversibility test after inhaling bronchodilator by forced oscillation technique (FOT) in addition to spirometry was investigated in the diagnosis of bronchial asthma (BA), cough variant asthma (CVA) and allergic rhinitis (AR) with prolonged or chronic cough. METHODS: The subjects were the 622 patients at Idaimaeminamiyojo Clinic in Sapporo who complained cough over three weeks, and underwent bronchial reversibility test with salbutamol by using spirometry and FOT...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/30022651/improvement-of-enzymatic-stability-and-catalytic-efficiency-of-recombinant-fusarium-oxysporum-trypsin-with-different-n-terminal-residues-produced-by-pichiapastoris
#3
Ning Yang, Zhenming Ling, Liang Peng, Yanlai Liu, Pu Liu, Kai Zhang, Aman Khan, Juanjuan Shi, Xiangkai Li
Fusarium oxysporum trypsin (FOT) is afungal serine protease similar to mammal trypsin. The FOT could be successfully expressed in Pichia pastoris by engineering the natural propeptideAPQEIPN.In this study, we constructed two recombinant enzymeswith engineeredamino acid sequences added to the N-terminus of FOT and expressed in P.pastoris . The N-terminal residues had various effects on the structural and functional properties of trypsin. The FOT, the recombinants TE (with peptide YVEF) and TS (with peptide YV) displayed the same optimum temperature (40 °C) and pH (8...
July 12, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29909073/changes-in-the-breath-sound-spectrum-with-bronchodilation-in-children-with-asthma
#4
Mariko Nukaga, Hideyuki Tabata, Mayumi Enseki, Kota Hirai, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND: Breath sound parameters have been suggested to be new biomarkers of airway function in patients with asthma. METHODS: We investigated the effect of bronchodilation on breath sound parameters in sixty-four children (mean age, 8.9 years; range, 6-16 years) using a breath sound analyzer. The breath sound parameters included frequency limiting 50% and 99% of the power spectrum (F50 and F99 ), roll-off from 600-1200 Hz (slope), and spectrum curve indices such as the ratios of the third and fourth power area to the total area of the power spectrum (P3 /PT and P4 /PT ), total area under the curve (A3 /AT and B4 /AT ), and the ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF75 and RPF50 )...
June 13, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29902839/mir-374b-promotes-proliferation-and-inhibits-apoptosis-of-human-gist-cells-by-inhibiting-pten-through-activation-of-the-pi3k-akt-pathway
#5
Zi-Wen Long, Jiang-Hong Wu, Cai-Hong, Ya-Nong Wang, Ye Zhou
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR-374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1...
June 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29898426/resilience-and-reliability-of-compact-vertical-flow-treatment-wetlands-designed-for-tropical-climates
#6
R Lombard-Latune, L Pelus, N Fina, F L'Etang, B Le Guennec, P Molle
Most of the tropical areas have sanitation problems to contend with. The French system of vertical-flow treatment wetlands (FS-VFTW) fed with raw wastewater could be a good water and sludge management solution. The purpose-adapted tropical design can reduce area requirement to below 1 m2 /population equivalents (p.e.). The Taupinière FS-VFTW on Martinique Island was built according to this design, with one stage but with a saturated layer at the bottom of the filter and a simplified trickling filter (TF) added for further treatment to meet the high performances targeted...
November 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29892193/diversity-of-respiratory-impedance-based-on-quantitative-computed-tomography-in-patients-with-copd
#7
Yosuke Wada, Yoshiaki Kitaguchi, Masanori Yasuo, Fumika Ueno, Satoshi Kawakami, Kiyoyasu Fukushima, Keisaku Fujimoto, Masayuki Hanaoka
Introduction: This study was conducted in order to investigate the diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative computed tomography (CT) in patients with COPD. Patients and methods: Medical records of 174 stable COPD patients were retrospectively reviewed to obtain the patients' clinical data, including the pulmonary function and imaging data. According to the software-based quantification of the degree of emphysema and airway wall thickness, the patients were classified into the "normal by CT" phenotype, the airway-dominant phenotype, the emphysema-dominant phenotype, and the mixed phenotype...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29799289/bronchodilator-responses-in-respiratory-impedance-hyperinflation-and-gas-trapping-in-copd
#8
Stephen Milne, Christoph Hammans, Stella Watson, Claude S Farah, Cindy Thamrin, Gregory G King
Hyperinflation, gas trapping and their responses to long-acting bronchodilator are clinically important in COPD. The forced oscillation technique (FOT) measures of respiratory system resistance and reactance are sensitive markers of bronchodilator response in COPD. The relationships between changes in resistance and reactance, and changes in hyperinflation and gas trapping, following long-acting bronchodilator (LA-BD) have not been studied. 15 subjects with mild-moderate COPD underwent FOT, spirometry then body plethysmography, before and 2 hours after a single 150 microg dose of the LA-BD indacaterol...
May 25, 2018: COPD
https://www.readbyqxmd.com/read/29773293/usefulness-of-the-forced-oscillation-technique-in-assessing-the-therapeutic-result-of-tracheobronchial-central-airway-obstruction
#9
Masanori Yasuo, Yoshiaki Kitaguchi, Fumiya Kinota, Makoto Kosaka, Kazuhisa Urushihata, Atsuhito Ushiki, Hiroshi Yamamoto, Satoshi Kawakami, Masayuki Hanaoka
BACKGROUND: Pulmonary function tests (PFTs) comprise the traditional method for detecting central airway obstruction (CAO) and evaluating therapeutic effects, but are effort-dependent. By contrast, the forced oscillation technique (FOT) is performed during tidal breathing in an effort-independent mode and is universally used to assess respiratory function in patients with chronic obstructive pulmonary disease (COPD) and asthma. We used the FOT to measure airway resistance and reactance in patients with CAO before and after interventional bronchoscopy and compared the results to data obtained using PFTs...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29772569/evaluation-of-inhaled-procaterol-for-potential-assist-use-in-patients-with-stable-chronic-obstructive-pulmonary-disease
#10
Norio Kodaka, Toru Yamagishi, Kayo Watanabe, Kumiko Kishimoto, Chihiro Nakano, Takeshi Oshio, Kumiko Niitsuma, Nagashige Shimada, Hiroto Matsuse
OBJECTIVES: International guidelines recommend the use of long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease (COPD), but the usefulness of short-acting bronchodilator assist use for stable COPD remains uncertain. The purpose of the present study was to objectively demonstrate the effects of assist use of procaterol, a short-acting -agonist, on the respiratory mechanics of stable COPD patients treated with a long-acting bronchodilator using forced oscillation technique (FOT) and conventional spirometry...
May 17, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29761950/-optimization-of-the-pseudorandom-input-signals-used-for-the-forced-oscillation-technique
#11
Xiaoli Liu, Nan Zhang, Hong Liang, Zhengbo Zhang, Deyu Li, Weidong Wang
The forced oscillation technique (FOT) is an active pulmonary function measurement technique that was applied to identify the mechanical properties of the respiratory system using external excitation signals. FOT commonly includes single frequency sine, pseudorandom and periodic impulse excitation signals. Aiming at preventing the time-domain amplitude overshoot that might exist in the acquisition of combined multi sinusoidal pseudorandom signals, this paper studied the phase optimization of pseudorandom signals...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29557669/telemonitoring-in-copd-the-chromed-study-a-randomized-clinical-trial
#12
Paul P Walker, Pasquale P Pompilio, Paolo Zanaboni, Trine S Bergmo, Kaiu Prikk, Andrei Malinovschi, Josep M Montserrat, Jo Middlemass, Silvana Šonc, Giulia Munaro, Dorjan Marušič, Ruth Sepper, Roberto Rosso, A Niroshan Siriwardena, Christer Janson, Ramon Farre, Peter M A Calverley, Raffaele L Dellaca'
RATIONALE: Early detection of COPD exacerbations using tele-monitoring of physiological variables might reduce the frequency of hospitalisation. OBJECTIVES: To evaluate the efficacy of home monitoring of lung mechanics by the forced oscillation technique (FOT) and cardiac parameters in older COPD patients with co-morbidities. METHODS: This multicentre, randomized clinical trial recruited 312 GOLD grade II-IV COPD patients (median age 71 years [IQR:66-76], 49...
March 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29543132/oscillometry-and-pulmonary-mri-measurements-of-ventilation-heterogeneity-in-obstructive-lung-disease-relationship-to-quality-of-life-and-disease-control
#13
Heather M Young, Fumin Guo, Rachel L Eddy, Geoffrey Maksym, Grace Parraga
Ventilation heterogeneity is a hallmark finding in obstructive lung disease and may be evaluated using a variety of methods, including multiple-breath gas washout and pulmonary imaging. Such methods provide an opportunity to better understand the relationships between structural and functional abnormalities in the lungs, and their relationships with important clinical outcomes. We measured ventilation heterogeneity and respiratory impedance in 100 subjects [50 patients with asthma, 22 ex-smokers, and 28 patients with chronic obstructive pulmonary disease (COPD)] using oscillometry and hyperpolarized 3 He magnetic resonance imaging (MRI) and determined their relationships with quality of life scores and disease control/exacerbations...
July 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29528572/respiratory-function-in-healthy-emirati-children-using-forced-oscillations
#14
Afaf AlBlooshi, Alia AlKalbani, Hassib Narchi, Sania Al-Hamad, Mohammed Al-Houqani, Ghaya AlBadi, Abdul-Kader Souid, Graham L Hall
BACKGROUND: The forced oscillation technique (FOT) allows the quantification of respiratory function, does not require active cooperation and as such is ideally suited for use in young children. The application of the FOT in non-Caucasian populations is limited and it remains unclear if current reference ranges for the FOT in Caucasian children are appropriate for children in the Arabian Peninsula. This study explored the use of the FOT in healthy school-aged children in the United Arab Emirates (UAE)...
July 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29501245/forty-years-of-reference-values-for-respiratory-system-impedance-in-adults-1977-2017
#15
REVIEW
Or Kalchiem-Dekel, Stella E Hines
OBJECTIVE: To provide an evidence-based review of published data regarding normal range reference values and prediction equations for measurements of respiratory impedance using forced oscillation technique (FOT) and impulse oscillometry (IOs) in adults. METHODS: A non-language-restricted search was performed using forced oscillation technique and impulse oscillometry as primary terms. Original research studies reporting respiratory system impedance reference values or prediction equations based on cohorts of ≥100 healthy adults were included...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29470844/reference-values-for-respiratory-impedance-measured-by-the-forced-oscillation-technique-in-adult-men-and-women
#16
Fernando Carlos Vetromille Ribeiro, Agnaldo José Lopes, Pedro Lopes de Melo
INTRODUCTION: The forced oscillation technique (FOT) is a particularly useful test of the mechanical properties of the respiratory system that has an increasingly important role in lung function laboratories. There is general agreement in the literature that the determination of reference values is of utmost importance in the clinical use of the FOT. OBJECTIVE: Our aim was to present reference values for whole-breath FOT measurements, establish which anthropometric variables were more predictive of impedance parameters, and provide all the details to adequately adopt these reference equations in individual laboratories...
June 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29447073/the-benefits-and-risks-of-expressing-the-pot-and-fot-family-of-oligopeptide-transporters-in-saccharomyces-cerevisiae
#17
Kenji Kitamura, Eldaa Zefany Banami Kinsui
In the yeast Saccharomyces cerevisiae, all strains possess a gene for the evolutionarily conserved POT family peptide transporter, Ptr2; however, the genes for a novel FOT family transporter were found only in some wine brewing strains. The substrate specificity of the POT and FOT family of transporters was compared. Among the naturally occurring oligopeptides that were tested, Lys-Leu and Arg-Phe were Ptr2-specific substrates. Artificial dipeptide aspartame was imported specifically through the FOT transporter, but the structurally similar Asp-Phe was a substrate of both FOT and Ptr2 transporters...
March 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29402049/unlocking-high-spatial-resolution-in-neutron-imaging-through-an-add-on-fibre-optics-taper
#18
M Morgano, P Trtik, M Meyer, E H Lehmann, J Hovind, M Strobl
The demand for high resolution neutron imaging has been steadily increasing over the past years. The number of facilities offering cutting edge resolution is however limited, due to (i) the design complexity of an optimized device able to reach a resolution in the order of ≈ 10 μm and (ii) limitations in available neutron flux. Here we propose a simple addition, based on a Fibre Optics Taper (FOT), that can be easily attached to an already existing scintillator-camera imaging detector in order to efficiently increase its spatial resolution and hence boost the capability of an instrument into high resolution applications...
January 22, 2018: Optics Express
https://www.readbyqxmd.com/read/29394894/differential-effects-of-innate-immune-variants-of-surfactant-protein-a1-sftpa1-and-sp-a2-sftpa2-in-airway-function-after-klebsiella-pneumoniae-infection-and-sex-differences
#19
Nithyananda Thorenoor, Xuesheng Zhang, Todd M Umstead, E Scott Halstead, David S Phelps, Joanna Floros
BACKGROUND: Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, encoding SP-A1 and SP-A2 proteins, respectively and each is identified with numerous genetic variants. These differentially enhance bacterial phagocytosis, with SP-A2 variants being more effective than SP-A1. METHODS: Lung functions of humanized transgenic (hTG) mice that carry different SP-A1 and SP-A2 variants or both variants SP-A1/SP-A2 (6A2 /1A0 , co-ex), as well as SP-A knockout (KO), were studied...
February 3, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29354485/is-forced-oscillation-technique-the-next-respiratory-function-test-of-choice-in-childhood-asthma
#20
REVIEW
Afaf Alblooshi, Alia Alkalbani, Ghaya Albadi, Hassib Narchi, Graham Hall
Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to perform forced expiratory manoeuvre. The development of novel diagnostic methods which require minimal effort, such as forced oscillation technique (FOT) is, therefore, a welcome and promising addition. FOT involves applying external, small amplitude oscillations to the respiratory system during tidal breathing...
December 26, 2017: World Journal of Methodology
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