Read by QxMD icon Read


Yu-Chuan Wang, Bo Huang, Kang Li, Peng-Kang He, Er-Dong Chen, Yu-Long Xia, Jie Jiang, Qin-Hui Sheng, Jing Zhou, Yan-Sheng Ding
Objectives: To identify optimal predefined criteria (OPC) for filters of the VisiTag™ module in the CARTO 3 system during pulmonary vein isolation (PVI). Methods: Thirty patients with atrial fibrillation (AF) who experienced PVI first were enrolled. PVI was accomplished by using a Thermocool SmartTouch catheter. Ablation lesions were tagged automatically as soon as predefined criteria of the VisiTag™ module were met. OPC should be that ablation with the setting resulting in the conduction gap (CG) as few as possible, while contiguous encircling ablation line (CEAL) without the tag gap (TG) on the 3D anatomic model as much as possible...
2018: Cardiology Research and Practice
Behrouz Mostafavi, Sandra Diaz, Eeva Piitulainen, Berend C Stoel, Per Wollmer, Hanan A Tanash
Background: Alpha-1-antitrypsin (AAT) deficiency is a hereditary disorder that predisposes to emphysema. A cohort of severe (PiZZ) and moderate (PiSZ) AAT-deficient newborn infants was identified by the Swedish national neonatal AAT screening program in 1972-1974 and has been followed-up since birth. Our aim was to study whether the cohort has signs of emphysema in pulmonary function tests (PFTs) and computed tomography (CT) densitometry at 38 years of age in comparison with an age-matched control group, randomly selected from the population registry...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Ryan P Butzko, Anays M Sotolongo, Drew A Helmer, Jacquelyn C Klein-Adams, Omowunmi Y Osinubi, Andrew R Berman, Ronaldo Ortiz-Pacheco, Michael J Falvo
PURPOSE: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. METHODS: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV1 /FVC, FEV1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal...
November 30, 2018: Respiratory Physiology & Neurobiology
Diane M Gray, Dorottya Czovek, Lauren McMillan, Lidija Turkovic, Jacob A M Stadler, Anessa Vanker, Bence L Radics, Zoltan Gingl, Graham L Hall, Peter D Sly, Heather J Zar, Zoltán Hantos
RATIONALE: Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and non-invasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. OBJECTIVE: To investigate whether lung function derived from the intra-breath forced oscillation technique (FOT), was able to identify healthy infants at risk of LRTI in the first year. METHODS AND MEASUREMENTS: Lung function was measured with the novel intra-breath FOT, in six-week infants in a South African birth cohort (Drakenstein Child Health Study)...
November 21, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Genny Raffaeli, Chiara Veneroni, Stefano Ghirardello, Anna Lavizzari, Sofia Passera, Fabio Mosca, Giacomo Cavallaro, Raffaele L Dellacà
Respiratory management during extracorporeal membrane oxygenation (ECMO) is complex. Assessment of lung mechanics might support a patient-tailored ventilatory strategy. We report, for the first time, the use of the forced oscillation technique (FOT) to evaluate lung function during neonatal ECMO to improve the individualization of respiratory support. The patient was a formerly preterm infant at a corrected age of 40 weeks (gestational age 32 weeks) undergoing veno-arterial ECMO for refractory respiratory failure secondary to influenza A (H1N1) pneumonia...
2018: Frontiers in Pediatrics
Ning Yang, Zhenming Ling, Liang Peng, Yanlai Liu, Pu Liu, Kai Zhang, Aman, Juanjuan Shi, Xiangkai Li
Fusarium oxysporum trypsin (FOT) is a fungal serine protease similar to mammal trypsin. The FOT could be successfully expressed in Pichiapastoris by engineering the natural propeptide APQEIPN. In this study, we constructed two recombinant enzymes with engineered amino acid sequences added to the N-terminus of FOT and expressed in P. pastoris . The N-terminal residues had various effects on the structural and functional properties of trypsin. The FOT, and the recombinants TE (with peptide YVEF) and TS (with peptide YV) displayed the same optimum temperature (40°C) and pH (8...
September 28, 2018: Journal of Microbiology and Biotechnology
Caroline Oliveira Ribeiro, Alvaro Camilo Dias Faria, Agnaldo José Lopes, Pedro Lopes de Melo
Purpose: The aim of the present study was to evaluate the performance of the forced oscillation technique (FOT) for the early diagnosis of the effects of smoking and COPD. The contributions of the integer-order (InOr) and fractional-order (FrOr) models were also evaluated. Patients and methods: In total, 120 subjects were analyzed: 40 controls, 40 smokers (20.3±9.3 pack-years) and 40 patients with mild COPD. Results: Initially, it was observed that traditional FOT parameters and the InOr and FrOr models provided a consistent description of the COPD pathophysiology...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Enrico Lombardi, Valentina Fainardi, Claudia Calogero, Monia Puglia, Fabio Voller, Marina Cuttini, Franca Rusconi
OBJECTIVE: We assessed lung function and respiratory health in an area-based prospective cohort of preschool children born very preterm. DESIGN: Lung function was measured by interrupter respiratory resistance (Rint) and forced oscillation technique (FOT) (respiratory resistance (Rrs8), reactance (Xrs8), and area under the reactance curve (AX)) at a median age of 5.2 years in a cohort of 194 children born at 22-31 weeks of gestational age (GA) in Tuscany, Italy...
October 21, 2018: Pediatric Pulmonology
Nengchao Lyu, Yue Cao, Chaozhong Wu, Jin Xu, Lian Xie
Deceleration lanes improve traffic flow by reducing interference, increasing capacity and enhancing safety. However, accident rates are higher on these interchange segments than on other freeway segments. It is important to attempt to reduce traffic accidents on these interchange segments by further exploring the behavior of different types of drivers on a highway deceleration lane. In this study, with field operational test (FOT) data from 89 driving instances (derived from 46 participants driving the test road twice) on a typical freeway deceleration lane, section speed profiles, vehicle trajectories, lane position and other key parameters were obtained...
September 17, 2018: Accident; Analysis and Prevention
L Starczewska-Dymek, A Bozek, M Jakalski
The forced oscillation technique (FOT) requires minimal patient cooperation and is useful for children. However, comprehensive values of respiratory impedance at baseline and after the reversibility test have not been definitively confirmed. The aim of this study was to evaluate the basic parameters of FOT reactance (Xrs) and resistance (Rrs) in groups of healthy children and children with controlled and uncontrolled asthma. The second aim was the assessment of the reversibility bronchial test using the forced oscillation method in children with bronchial asthma...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
L S Jiang, B He
No abstract text is available yet for this article.
August 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Chiara Veneroni, Linda Wallström, Richard Sindelar, Raffaele L Dellacaʼ
BACKGROUND: We aimed to evaluate if lung mechanics measured by forced oscillatory technique (FOT) during the first day of life help identify extremely low gestational age newborns (ELGANs) at risk of prolonged mechanical ventilation (MV) and oxygen dependency. METHODS: Positive end-expiratory pressure (PEEP) was increased 2 cmH2 O above the clinically set PEEP, then decreased by four 5-min steps of 1 cmH2 O, and restored at the clinical value. At each PEEP, FOT measurements were performed bedside during MV...
August 4, 2018: Pediatric Research
K Nilsen, K Gove, F Thien, T Wilkinson, B R Thompson
Airway closure has proved to be important in a number of respiratory diseases and may be the primary functional defect in asthma. A surrogate measure of closing volume can be identified using the forced oscillation technique (FOT), by performing a deflation maneuver and examining the resultant reactance (Xrs) lung volume relationship. This study aims to determine if a slow vital capacity maneuver can be used instead of this deflation maneuver and compare it to existing more complex techniques. Three subject groups were included in the study; healthy (n = 29), asthmatic (n = 18), and COPD (n = 10) for a total of 57 subjects...
October 2018: European Journal of Applied Physiology
Kan Kato, Hiroshi Tanaka
BACKGROUND: Usefulness of carrying out the reversibility test after inhaling bronchodilator by forced oscillation technique (FOT) in addition to spirometry was investigated in the diagnosis of bronchial asthma (BA), cough variant asthma (CVA) and allergic rhinitis (AR) with prolonged or chronic cough. METHODS: The subjects were the 622 patients at Idaimaeminamiyojo Clinic in Sapporo who complained cough over three weeks, and underwent bronchial reversibility test with salbutamol by using spirometry and FOT...
2018: Arerugī, [Allergy]
Ning Yang, Zhenming Ling, Liang Peng, Yanlai Liu, Pu Liu, Kai Zhang, Aman Khan, Juanjuan Shi, Xiangkai Li
Fusarium oxysporum trypsin (FOT) is afungal serine protease similar to mammal trypsin. The FOT could be successfully expressed in Pichia pastoris by engineering the natural propeptideAPQEIPN.In this study, we constructed two recombinant enzymeswith engineeredamino acid sequences added to the N-terminus of FOT and expressed in P.pastoris . The N-terminal residues had various effects on the structural and functional properties of trypsin. The FOT, the recombinants TE (with peptide YVEF) and TS (with peptide YV) displayed the same optimum temperature (40 °C) and pH (8...
July 12, 2018: Journal of Microbiology and Biotechnology
Mariko Nukaga, Hideyuki Tabata, Mayumi Enseki, Kota Hirai, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND: Breath sound parameters have been suggested to be new biomarkers of airway function in patients with asthma. METHODS: We investigated the effect of bronchodilation on breath sound parameters in sixty-four children (mean age, 8.9 years; range, 6-16 years) using a breath sound analyzer. The breath sound parameters included frequency limiting 50% and 99% of the power spectrum (F50 and F99 ), roll-off from 600-1200 Hz (slope), and spectrum curve indices such as the ratios of the third and fourth power area to the total area of the power spectrum (P3 /PT and P4 /PT ), total area under the curve (A3 /AT and B4 /AT ), and the ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF75 and RPF50 )...
September 2018: Respiratory Investigation
Zi-Wen Long, Jiang-Hong Wu, Cai-Hong, Ya-Nong Wang, Ye Zhou
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR-374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1...
June 2018: Molecules and Cells
R Lombard-Latune, L Pelus, N Fina, F L'Etang, B Le Guennec, P Molle
Most of the tropical areas have sanitation problems to contend with. The French system of vertical-flow treatment wetlands (FS-VFTW) fed with raw wastewater could be a good water and sludge management solution. The purpose-adapted tropical design can reduce area requirement to below 1 m2 /population equivalents (p.e.). The Taupinière FS-VFTW on Martinique Island was built according to this design, with one stage but with a saturated layer at the bottom of the filter and a simplified trickling filter (TF) added for further treatment to meet the high performances targeted...
November 15, 2018: Science of the Total Environment
Yosuke Wada, Yoshiaki Kitaguchi, Masanori Yasuo, Fumika Ueno, Satoshi Kawakami, Kiyoyasu Fukushima, Keisaku Fujimoto, Masayuki Hanaoka
Introduction: This study was conducted in order to investigate the diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative computed tomography (CT) in patients with COPD. Patients and methods: Medical records of 174 stable COPD patients were retrospectively reviewed to obtain the patients' clinical data, including the pulmonary function and imaging data. According to the software-based quantification of the degree of emphysema and airway wall thickness, the patients were classified into the "normal by CT" phenotype, the airway-dominant phenotype, the emphysema-dominant phenotype, and the mixed phenotype...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Stephen Milne, Christoph Hammans, Stella Watson, Claude S Farah, Cindy Thamrin, Gregory G King
Hyperinflation, gas trapping and their responses to long-acting bronchodilator are clinically important in COPD. The forced oscillation technique (FOT) measures of respiratory system resistance and reactance are sensitive markers of bronchodilator response in COPD. The relationships between changes in resistance and reactance, and changes in hyperinflation and gas trapping, following long-acting bronchodilator (LA-BD) have not been studied. 15 subjects with mild-moderate COPD underwent FOT, spirometry then body plethysmography, before and 2 hours after a single 150 microg dose of the LA-BD indacaterol...
May 25, 2018: COPD
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"