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https://www.readbyqxmd.com/read/28944932/new-treatment-for-non-hodgkin-b-cell-lymphomas-with-a-special-focus-on-the-impact-of-junctional-adhesion-molecules
#1
Beat Albert Imhof, Thomas Matthes
Current therapeutic modalities used for B-cell lymphoma include chemotherapy, immunotherapy, and radiation therapy. Chemotherapy together with anti-CD20 monoclonal antibodies forms the cornerstone of therapy and has a curative, as well as a palliative, role in this disease. New treatment modalities targeting specific molecules on the surface of lymphoma cells or intracellular pathways regulating apoptosis, proliferation and cell division are intensively investigated. One such target is JAM-C, a molecule implicated in cell adhesion and in B cell migration and whose inhibition blocks B cells from reaching their supportive microenvironments in lymphoid organs...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944565/novel-tetrahydroacridine-derivatives-with-iodobenzoic-acid-moiety-as-multifunctional-acetylcholinesterase-inhibitors
#2
Robert Skibiński, Kamila Czarnecka, Małgorzata Girek, Ireneusz Bilichowski, Nina Chufarova, Elżbieta Mikiciuk-Olasik, Paweł Szymański
New synthesized series of 9-amino-1,2,3,4-tetrahydroacridine derivatives with iodobenzoic acid moiety were studied for their inhibitory activity towards cholinesterase and against β-amyloid aggregation. All novel molecules 3a-3i interacted with both cholinesterases - acetylcholinesterase and butyrylcholinesterase, delivered nanomolar IC50 values. The structure-activity relationship showed that N-butyl moiety derivatives are stronger inhibitors towards AChE and BuChE than N-ethyl and N-propyl moieties compounds...
September 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28944079/quantitative-systems-biology-to-decipher-design-principles-of-a-dynamic-cell-cycle-network-the-maximum-allowable-mammalian-trade-off-weight-mamtow
#3
REVIEW
Matteo Barberis, Paul Verbruggen
Network complexity is required to lend cellular processes flexibility to respond timely to a variety of dynamic signals, while simultaneously warranting robustness to protect cellular integrity against perturbations. The cell cycle serves as a paradigm for such processes; it maintains its frequency and temporal structure (although these may differ among cell types) under the former, but accelerates under the latter. Cell cycle molecules act together in time and in different cellular compartments to execute cell type-specific programs...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28943440/molecular-imprinted-chitosan-tio2-nanocomposite-for-the-selective-removal-of-rose-bengal-from-wastewater
#4
Mohamed A Ahmed, Nader M Abdelbar, Ashraf A Mohamed
A new molecularly imprinted polymer (MIP) chitosan-TiO2 nanocomposite (CTNC) was prepared for the selective and quantitative removal of Rose Bengal dye from industrial wastewater. The physicochemical features of the prepared CTNC-MIP nanoparticles were thoroughly investigated. The prepared MIP nanoparticles exhibited high surface area (95.38m(2)/g) with relatively uniform mesoporous channels that allowed an exceptional uptake of the dye (qm=79.365mg/g) and reflected the high selectivity of the prepared MIP compared to pure chitosan...
September 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28943299/interaction-of-quindoline-derivative-with-telomeric-repeat-containing-rna-induces-telomeric-dna-damage-response-in-cancer-cells-through-inhibition-of-telomeric-repeat-factor-2
#5
Yan Zhang, Deying Zeng, Jiaojiao Cao, Mingxue Wang, Bing Shu, Guotao Kuang, Tian-Miao Ou, Jia-Heng Tan, Lian-Quan Gu, Zhi-Shu Huang, Ding Li
BACKGROUND: Telomeric repeat-containing RNA (TERRA) is a large non-coding RNA in mammalian cells, which forms an integral component of telomeric heterochromatin. TERRA can bind to an allosteric site of telomeric repeat factor 2 (TRF2), a key component of Shelterin that protect chromosome termini. Both TERRA and TRF2 have been recognized as promising new therapeutic targets for cancer treatment. METHODS: Our methods include FRET assay, SPR, CD, microscale thermophoresis (MST), enzyme-linked immunosorbent assay (ELISA), chromatin immunoprecipitation (ChIP), colony formation assays, Western blot, immunofluorescence, cell cycle arrest and apoptosis detection, and xCELLigence real-time cell analysis (RTCA)...
September 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28943273/small-molecule-targeting-of-ptps-in-cancer
#6
REVIEW
John S Lazo, Kelley E McQueeney, James C Burnett, Peter Wipf, Elizabeth R Sharlow
Protein tyrosine phosphatases (PTPs) undeniably have a central role in the development and progression of human cancers. Historically, however, PTPs have not been viewed as privileged drug targets, and progress on identifying potent, selective, and cell-active small molecule PTP inhibitors has suffered accordingly. This situation is rapidly changing, however, due to biochemical advances in the study of PTPs and recent small molecule screening campaigns, which have identified potent and mechanistically diverse lead structures...
September 21, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28943244/new-5-ht1a-5ht2a-and-5ht2c-receptor-ligands-containing-a-picolinic-nucleus-synthesis-in-vitro-and-in-vivo-pharmacological-evaluation
#7
Ferdinando Fiorino, Elisa Magli, Ewa Kędzierska, Antonio Ciano, Angela Corvino, Beatrice Severino, Elisa Perissutti, Francesco Frecentese, Paola Di Vaio, Irene Saccone, Angelo A Izzo, Raffaele Capasso, Paola Massarelli, Ilaria Rossi, Jolanta Orzelska-Gòrka, Jolanta Helena Kotlińska, Vincenzo Santagada, Giuseppe Caliendo
Picolinamide derivatives, linked to an arylpiperazine moiety, were prepared and their affinity to 5-HT1A, 5-HT2A and 5-HT2C receptors was evaluated. The combination of structural elements (heterocyclic nucleus, alkyl chain and 4-substituted piperazine), known to play critical roles in affinity for serotoninergic receptors, and the proper selection of substituents led to compounds with high specificity and affinity towards serotoninergic receptors. In binding studies, several molecules showed high affinity in nanomolar and subnanomolar range at 5-HT1A, 5-HT2A and 5-HT2C receptors and moderate or no affinity for other relevant receptors (D1, D2, α1 and α2)...
September 18, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28943206/kaolinite-in-pharmaceutics-and-biomedicine
#8
REVIEW
Mahmoud E Awad, Alberto López-Galindo, Massimo Setti, Mahmoud M El-Rahmany, César Viseras Iborra
Kaolinite Al2Si2O5(OH)4 is an abundant and inexpensive geomaterial regarded as one of the most common clay minerals in the earth's crust and the most widespread phase among the other kaolin polymorphs (halloysite, dickite and nacrite). Structurally, it is a hydrous aluminum phyllosilicate member belonging to the dioctahedral 1:1 kaolin mineral group. The particle size of the pseudohexagonal kaolinite platelets is normally <2μm (if compared to a human red blood cell of a typical diameter 6.2-8.2μm or to a virus particle of about 50nm diameter)...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28943093/naturak-killer-cell-immunotherapies-against-cancer-checkpoint-inhibitors-and-more
#9
REVIEW
Laura Chiossone, Margaux Vienne, Yann M Kerdiles, Eric Vivier
After many years of research, recent advances have shed new light on the role of the immune system in advanced-stage cancer. Various types of immune cells may be useful for therapeutic purposes, along with chemical molecules and engineered monoclonal antibodies. The immune effectors suitable for manipulation for adoptive transfer or drug targeting in vivo include natural killer (NK) cells. These cells are of particular interest because they are tightly regulated by an array of inhibitory and activating receptors, enabling them to kill tumor cells while sparing normal cells...
September 21, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28942821/medicinal-plant-products-targeting-quorum-sensing-for-combating-bacterial-infections
#10
REVIEW
Abdelhakim Bouyahya, Nadia Dakka, Abdeslam Et-Touys, Jamal Abrini, Youssef Bakri
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942790/glucagon-like-peptide-1-receptor-agonists-a-class-update-for-treating-type-2-diabetes
#11
REVIEW
Julie A Lovshin
Current management options for treating type 2 diabetes are diverse. Many different classes of antidiabetes therapies are used in clinic, and several new candidates are in late-phase clinical trial. This therapeutic abundance is a windfall for patients because it facilitates individualized patient care. Evidence-based positioning of these agents is challenging, however, requiring comprehensive and balanced familiarity with each drug class. In this review, I provide a clinical update of glucagon-like peptide-1 receptor agonists (GLP-1RAs), a class of incretin-based, injectable antidiabetes therapies which improve fasting and postprandial blood glucose control through glucose-dependent pancreatic islet cell hormone secretion without significant risks for hypoglycemia...
October 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28942664/-clinical-aspects-of-severe-infections-caused-by-antibiotic-resistant-gram-negative-bacteria-the-empire-strikes-back
#12
János Sinkó
In our days, growing incidence of antibiotic resistant bacteria has become an eminent public health problem. For survival Gram-negative species possess several different tools to withstand antibiotics: they produce degrading and modifying enzymes, decrease their permeability or expel drug molecules. An increasing proportion of severe nosocomial infections are caused by strains resistant to several antimicrobials (multiresistant, extensively resistant or panresistant species). Development of new antibiotic compounds may serve as a possible solution to this problem...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28942529/dft-study-of-benzyl-alcohol-tio2-interfacial-surface-complex-reaction-pathway-and-mechanism-of-visible-light-absorption
#13
Lei Zhao, Feng Long Gu, Minjae Kim, Maosheng Miao, Rui-Qin Zhang
We propose a new pathway for the adsorption of benzyl alcohol on the surface of TiO2 and the formation of interfacial surface complex (ISC). The reaction free energies and reaction kinetics were thoroughly investigated by density functional calculations. The TiO2 surfaces were modeled by clusters consisting of 4 Ti atoms and 18 O atoms passivated by H, OH group and H2O molecules. Compared with solid-state calculations utilizing the periodicity of the materials, such cluster modeling allows inclusion of the high-order correlation effects that seem to be essential for the adsorption of organic molecules onto solid surfaces...
September 24, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28942285/amentoflavone-suppresses-tumor-growth-in-ovarian-cancer-by-modulating-skp2
#14
Honggai Liu, Qingfen Yue, Shehong He
AIM: Ovarian cancer is one of most common malignancies in women and is associated with high reoccurrence rate and poor prognosis. This study is designed to investigate the anti-tumor effects of amentoflavone (AF), one of the major active ingredients of S. tamariscina, against ovarian cancer. MATERIALS AND METHODS: Human ovarian cancer cell lines SKOV3 and OVCAR-3 were used in this study. The effect of AF on cell viability was examined by CCK-8 assay. Cell apoptosis and cell cycle distribution was determined by flow cytometry...
September 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28942265/functionalization-of-single-solid-state-nanopores-to-mimic-biological-ion-channels-a-review
#15
REVIEW
Mathilde Lepoitevin, Tianji Ma, Mikhael Bechelany, Jean-Marc Janot, Sebastien Balme
In nature, ion channels are highly selective pores and act as gate to ensure selective ion transport, allowing ions to cross the membrane. By mimicking them, single solid state nanopore devices emerge as a new, powerful class of molecule sensors that allow for the label-free detection of biomolecules (DNA, RNA, and proteins), non-biological polymers, as well as small molecules. In this review, we exhaustively describe the fabrication and functionalization techniques to design highly robust and selective solid state nanopores...
September 14, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28942199/metabolomic-findings-in-sepsis-as-a-damage-of-host-microbial-metabolism-integration
#16
REVIEW
Natalia V Beloborodova, Andrei Yu Olenin, Alisa K Pautova
Metabolomics globally evaluates the totality of the endogenous metabolites in patient's body, at the same time reflecting gene function, enzyme activity and degree of organ dysfunction in sepsis. The authors performed the analysis of the main chemical classes of low molecular weight compounds (amino acids, polyols, fatty acids, hydroxy acids, amines, nucleotides and their derivatives) that quantitatively distinguish patients with sepsis from healthy ones. The following keywords were used to find papers published in the Scopus and Web of Science databases from 2008 to 2015: (marker OR biomarker) AND (sepsis OR critical ill OR pneumonia OR hypoxia)...
September 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28942195/short-overview-on-metabolomic-approach-and-redox-changes-in-psychiatric-disorders
#17
REVIEW
Gordana Nedic Erjavec, Marcela Konjevod, Matea Nikolac Perkovic, Dubravka Svob Strac, Lucija Tudor, Coral Barbas, Tilman Grune, Neven Zarkovic, Nela Pivac
Schizophrenia, depression and posttraumatic stress disorder (PTSD) are severe mental disorders and complicated diagnostic entities, due to their phenotypic, biological and genetic heterogeneity, unknown etiology, and poorly understood alterations in biological pathways and biological mechanisms. Disturbed homeostasis between overproduction of oxidant species, overcoming redox regulation and a lack of cellular antioxidant defenses, resulting in free radical-mediated pathology and subsequent neurotoxicity contributes to development of depression, schizophrenia and PTSD, their heterogeneous clinical presentation and resistance to treatment...
September 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28942174/gut-biofilm-forming-bacteria-in-inflammatory-bowel-disease
#18
REVIEW
Ankita Srivastava, Jaya Gupta, Sunil Kumar, Awanish Kumar
Inflammatory bowel disease (IBD) symbolizes a group of intestinal disorders in which prolonged inflammation occur in the digestive tract (esophagus, large intestine, small intestine mouth, stomach). Both genetic and environmental factors (infections, stress, diet) are involved in the development of IBD. As we know that bacteria are found in the intestinal mucosa of human and clinical observations revealed bacterial biofilms associated with patients of IBD. Various factors and microbes are found to play an essential role in biofilm formation and mucosal colonization during IBD...
September 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28942172/antigen-85-complex-as-a-powerful-mycobacterium-tuberculosis-immunogene-biology-immune-pathogenicity-applications-in-diagnosis-and-vaccine-design
#19
REVIEW
Mohsen Karbalaei Zadeh Babaki, Saman Soleimanpour, Seyed Abdolrahim Rezaee
Mycobacterium tuberculosis (Mtb) is one of the most life-threatening mycobacterial species which is increasing the death rate due to emerging multi-drug resistant (MDR) strains. Concerned health authorities worldwide are interested in developing an effective vaccine to prevent the spread of Mtb. After years of research, including successful identification of many Mtb immunogenic molecules, effective therapeutic agents or a vaccine have yet to be found. However, among the identified Mtb immunogenes, antigen 85 (Ag85) complex (Ag85A, Ag85B, and Ag85C) is receiving attention from scientists as it allows bacteria to evade the host immune response by preventing formation of phagolysosomes for eradication of infection...
September 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28942145/gut-microbial-metabolite-tmao-contributes-to-renal-dysfunction-in-a-mouse-model-of-diet-induced-obesity
#20
Guangping Sun, Zhongmin Yin, Naiquan Liu, Xiaohui Bian, Rui Yu, Xiaoxiao Su, Beiru Zhang, Yanqiu Wang
Emerging evidence shows that obesity induces renal injury and is an independent risk factor for the development of chronic kidney disease (CKD), even without diabetes or hyperglycemia. Although multiple metabolic factors have been suggested to account for obesity-associated renal injury, the precious underlying mechanisms are not completely understood. Recent study shows that increased trimethylamine N-Oxide (TMAO), a gut microbiota-generated metabolite, directly contributes to renal interstitial fibrosis and dysfunction...
September 20, 2017: Biochemical and Biophysical Research Communications
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