keyword
MENU ▼
Read by QxMD icon Read
search

New molecules

keyword
https://www.readbyqxmd.com/read/29156818/a-plasmid-containing-cpg-odn-as-vaccine-adjuvant-against-grass-carp-reovirus-in-grass-carp-ctenopharyngodon-idella
#1
Hang Su, Zhiwei Liao, Gailing Yuan, Jianguo Su
CpG oligodeoxynucleotides (ODNs) are proved to have strong immune stimulatory activity. Plasmids containing CpG ODNs could be conveniently and low-costly used as vaccine adjuvant. However, they are different among various plasmids, motif repeats, species, etc. In the present study, plasmid pcDNA3.1 (+) containing five repetitions of CpG ODN 1670A named pcDNA3.1-1670A*5 with strong immunostimulation was screened out from twelve recombinant plasmids and three empty vectors by cell proliferation activity, interferon promoter activities and immune related gene expressions in CIK cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156538/combined-effects-of-simulated-microgravity-and-radiation-exposure-on-osteoclast-cell-fusion
#2
Srinivasan Shanmugarajan, Ye Zhang, Maria Moreno-Villanueva, Ryan Clanton, Larry H Rohde, Govindarajan T Ramesh, Jean D Sibonga, Honglu Wu
The loss of bone mass and alteration in bone physiology during space flight are one of the major health risks for astronauts. Although the lack of weight bearing in microgravity is considered a risk factor for bone loss and possible osteoporosis, organisms living in space are also exposed to cosmic radiation and other environmental stress factors. As such, it is still unclear as to whether and by how much radiation exposure contributes to bone loss during space travel, and whether the effects of microgravity and radiation exposure are additive or synergistic...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156454/site-selective-and-stereoselective-functionalization-of-non-activated-tertiary-c-h-bonds
#3
Kuangbiao Liao, Thomas C Pickel, Vyacheslav Boyarskikh, John Bacsa, Djamaladdin G Musaev, Huw M L Davies
The synthesis of complex organic compounds usually relies on controlling the reactions of the functional groups. In recent years, it has become possible to carry out reactions directly on the C-H bonds, previously considered to be unreactive. One of the major challenges is to control the site-selectivity because most organic compounds have many similar C-H bonds. The most well developed procedures so far rely on the use of substrate control, in which the substrate has one inherently more reactive C-H bond or contains a directing group or the reaction is conducted intramolecularly so that a specific C-H bond is favoured...
November 20, 2017: Nature
https://www.readbyqxmd.com/read/29156447/pd-1-blockade-in-advanced-nsclc-a-focus-on-pembrolizumab
#4
REVIEW
Solange Peters, Keith M Kerr, Rolf Stahel
Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers and is responsible for a large proportion of all cancer-related deaths. Current treatment options are inadequate, reflecting a substantial unmet clinical need. Increasing knowledge regarding the mechanisms and genetic aberrations underlying tumor development and growth has heralded a new era of therapy in oncology, moving away from indiscriminate cytotoxic chemotherapy toward more finely focused, targeted medicine. The development of small-molecule drugs and monoclonal antibodies directed toward specific components of dysfunctional molecular or immune pathways, and mutated genes specific to particular cancer types, is leading the field to more personalized and less toxic treatment options, many of which have demonstrated greater efficacy and survival benefits than their chemotherapeutic counterparts...
October 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29156157/continuous-gradient-temperature-raman-spectroscopy-from-100-to-40%C3%A2-c-yields-new-molecular-models-of-arachidonic-acid-and-2-arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine
#5
C Leigh Broadhurst, Walter F Schmidt, Julie K Nguyen, Jianwei Qin, Kuanglin Chao, Moon S Kim
Despite its biochemical importance, a complete Raman analysis of arachidonic acid (AA, 20:4n-6) has never been reported. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we utilize the GTRS technique for AA and 1-18:0, 2-20:4n-6 phosphatidyl choline (AAPC) from cryogenic to mammalian body temperatures...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29156140/automated-training-of-reaxff-reactive-force-fields-for-energetics-of-enzymatic-reactions
#6
Tomáš Trnka, Igor Tvaroska, Jaroslav Koca
Computational studies of the reaction mechanisms of various enzymes are nowadays based almost exclusively on hybrid QM/MM models. Unfortunately, the success of this approach strongly depends on the selection of the QM region, and computational cost is a crucial limiting factor. An interesting alternative is offered by empirical reactive molecular force fields, especially the ReaxFF potential developed by van Duin and co-workers. However, even though an initial parameterization of ReaxFF for biomolecules already exists, it does not provide the desired level of accuracy...
November 20, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29156124/definition-of-free-o-h-groups-of-water-at-the-air-water-interface
#7
Fujie Tang, Tatsuhiko Ohto, Taisuke Hasegawa, Wen Jun Xie, Limei Xu, Mischa Bonn, Yuki Nagata
Free O-H groups of water are often found at the water-hydrophobic medium interface, e.g. for water contact with hydrophobic protein residues, or at the water-air interface. In surface-specific vibrational spectroscopic studies using sum-frequency generation (SFG) spectroscopy, free O-H groups are experimentally well characterized in the O-H stretch region by a sharp 3700 cm(-1) peak. Although these free O-H groups are often defined as the O-H groups which are not hydrogen-bonded to other water molecules, a direct correlation between such non-hydrogen-bonded O-H group and the 3700 cm(-1) SFG response has been lacking...
November 20, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29155959/the-discovery-potential-of-rna-processing-profiles
#8
Amadís Pagès, Ivan Dotu, Joan Pallarès-Albanell, Eulàlia Martí, Roderic Guigó, Eduardo Eyras
Small non-coding RNAs (sncRNAs) are highly abundant molecules that regulate essential cellular processes and are classified according to sequence and structure. Here we argue that read profiles from size-selected RNA sequencing capture the post-transcriptional processing specific to each RNA family, thereby providing functional information independently of sequence and structure. We developed SeRPeNT, a new computational method that exploits reproducibility across replicates and uses dynamic time-warping and density-based clustering algorithms to identify, characterize and compare sncRNAs by harnessing the power of read profiles...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155577/identification-of-conserved-water-sites-in-protein-structures-for-drug-design
#9
Marko Jukic, Janez Konc, Stanislav Gobec, Dusanka Janezic
Identification of conserved waters in protein structures is a challenging task with applications in molecular docking and protein stability prediction. As an alternative to computationally demanding simulations of proteins in water, experimental co-crystallized waters in the Protein Data Bank (PDB) in combination with a local structure alignment algorithm can be used for reliable prediction of conserved water sites. We developed the ProBiS H2O approach based on previously developed ProBiS algorithm, which enables identification of conserved water sites in proteins using experimental protein structures from the PDB or a set of custom protein structures available to the user...
November 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29155467/synthesis-characterisation-and-reactions-of-truly-cationic-ni-i-phosphine-complexes
#10
Ingo Krossing, Miriam Mareen Schwab, Daniel Himmel, Sylwia Kacprzak, Valentin Radtke, Daniel Kratzert, Philippe Weis, Melanie Wernet, Andreas Peter, Zeinab Yassine, Dominik Schmitz, Ernst-Wilhelm Scheidt, Wolfgang Scherer, Stefan Weber, Wolfram Feuerstein, Frank Breher, Alexander Higelin
The recently published purely metalorganic NiI salt [Ni(cod)2][Al(ORF)4] (1, cod = 1,5-cyclooctadiene, RF = C(CF3)3) provides a starting point for a new synthesis strategy leading to NiI phosphine complexes, replacing cod ligands by phosphines. Clearly visible colour changes indicate reactions within minutes, while quantum chemical calculations (PBE0-D3(BJ)/def2-TZVPP) approve exergonic reaction enthalpies in all performed ligand exchange reactions. Hence, [Ni(dppp)2][Al(ORF)4] (2, dppp = 1,3-Bis(diphenylphosphino)propane), [Ni(dppe)2][Al(ORF)4] (3, dppe = 1,3-Bis(diphenyl-phosphino)ethane), three-coordinate [Ni(PPh3)3][Al(ORF)4] (4) and a remarkable two-coordinate NiI phosphine complex [Ni(PtBu3)2][Al(ORF)4] (5) were characterised via single crystal X-ray structure analysis...
November 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29155438/circular-rnas-mediated-by-transposons-are-associated-with-transcriptomic-and-phenotypic-variation-in-maize
#11
Lu Chen, Pei Zhang, Yuan Fan, Qiong Lu, Qing Li, Jianbing Yan, Gary J Muehlbauer, Patrick S Schnable, Mingqiu Dai, Lin Li
Circular RNAs (circRNAs) are covalently closed RNA molecules. Recent studies have shown that circRNAs can arise from the transcripts of transposons. Given the prevalence of transposons in the maize genome and dramatic genomic variation driven by transposons, we hypothesize that transposons in maize may be involved in the formation of circRNAs and further modulate phenotypic variation. We performed circRNA-Seq on B73 seedling leaves and uncovered 2804 high-confidence maize circRNAs, which show distinct genomic features...
November 20, 2017: New Phytologist
https://www.readbyqxmd.com/read/29155428/small-molecule-inhibition-of-tlr8-through-stabilization-of-its-resting-state
#12
Shuting Zhang, Zhenyi Hu, Hiromi Tanji, Shuangshuang Jiang, Nabanita Das, Jing Li, Kentaro Sakaniwa, Jin Jin, Yanyan Bian, Umeharu Ohto, Toshiyuki Shimizu, Hang Yin
Endosomal Toll-like receptors (TLR3, TLR7, TLR8, and TLR9) are highly analogous sensors for various viral or bacterial RNA and DNA molecular patterns. Nonetheless, few small molecules can selectively modulate these TLRs. In this manuscript, we identified the first human TLR8-specific small-molecule antagonists via a novel inhibition mechanism. Crystal structures of two distinct TLR8-ligand complexes validated a unique binding site on the protein-protein interface of the TLR8 homodimer. Upon binding to this new site, the small-molecule ligands stabilize the preformed TLR8 dimer in its resting state, preventing activation...
November 20, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29155219/complement-anaphylatoxins-c3a-and-c5a-emerging-roles-in-cancer-progression-and-treatment
#13
REVIEW
Daniel Ajona, Sergio Ortiz-Espinosa, Ruben Pio
Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and therapeutic strategies. These two complement activation products can maintain chronic inflammation, promote an immunosuppressive microenvironment, induce angiogenesis, and increase the motility and metastatic potential of cancer cells. Still, the diverse heterogeneity of responses mediated by these peptides poses a challenge both to our understanding of the role played by these molecules in cancer progression and to the development of effective treatments...
November 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29155216/communication-between-genomic-and-non-genomic-signaling-events-coordinate-steroid-hormone-actions
#14
Sandi R Wilkenfeld, Chenchu Lin, Daniel E Frigo
Steroid hormones are lipophilic molecules produced in one cell that can travel great distances within the body to elicit biological effects in another cell. In the canonical pathway, steroid hormone binding to a nuclear receptor (NR), often in the cytoplasm, causes the receptor to undergo a conformational change and translocate to the nucleus, where it interacts with specific sequences of DNA to regulate transcription. In addition to the classical genomic mechanism of action, alternate mechanisms of steroid activity have emerged that involve rapid, non-genomic signaling...
November 16, 2017: Steroids
https://www.readbyqxmd.com/read/29155161/extracellular-vesicles-compartment-in-liquid-biopsies-clinical-application
#15
REVIEW
Noemi Garcia-Romero, Susana Esteban-Rubio, Gorjana Rackov, Josefa Carrión-Navarro, Cristobal Belda-Iniesta, Angel Ayuso-Sacido
Liquid biopsy is becoming a new source of biomarkers that complement and resolve some of the most important limitations of surgical biopsy, which are the accessibility to the diseased tissue and its heterogeneity, especially relevant for tumors. The diseased tissues release their molecule content to the bloodstream in free form, inside a cell or within extracellular vesicles (EVs). While the identification of molecular alterations in total DNA isolated from peripheral blood is already in use for some tumors that secrete large amounts of DNA, it is challenging to assay those secreting lower amounts of molecules as well as for many other non-tumoral pathologies like immunological and cardiovascular diseases...
November 16, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29155160/%C3%AE-v%C3%AE-3-and-%C3%AE-5%C3%AE-1-integrin-specific-ligands-from-tumor-angiogenesis-inhibitors-to-vascularization-promoters-in-regenerative-medicine
#16
REVIEW
Luís A Rocha, David A Learmonth, Rui A Sousa, António J Salgado
Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integrins involved in tumor angiogenesis and brake disease progression has resulted in new investigational drug entities reaching the clinical trial phase in humans. The use of integrin-specific ligands can be useful for the vascularization of regenerative medicine constructs, which remains a major limitation for translation into clinical practice...
November 15, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29155147/selective-and-membrane-permeable-small-molecule-inhibitors-of-nicotinamide-n-methyltransferase-reverse-high-fat-diet-induced-obesity-in-mice
#17
Harshini Neelakantan, Virginia Vance, Michael D Wetzel, Hua-Yu Leo Wang, Stanton F McHardy, Celeste C Finnerty, Jonathan D Hommel, Stanley J Watowich
There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities. A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis. To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors...
November 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29155098/orai1-mutations-abolishing-store-operated-ca-2-entry-cause-anhidrotic-ectodermal-dysplasia-with-immunodeficiency-eda-id
#18
Jayson Lian, Mario Cuk, Sascha Kahlfuss, Lina Kozhaya, Martin Vaeth, Frédéric Rieux-Laucat, Capucine Picard, Melina J Benson, Antonia Jakovcevic, Karmen Bilic, Iva Martinac, Peter Stathopulos, Imre Kacskovics, Thomas Vraetz, Carsten Speckmann, Stephan Ehl, Thomas Issekutz, Derya Unutmaz, Stefan Feske
BACKGROUND: Store-operated Ca(2+) entry (SOCE) through Ca(2+) release-activated Ca(2+) (CRAC) channels is an essential signaling pathway in many cell types. CRAC channels are formed by ORAI1, ORAI2 and ORAI3 proteins and activated by stromal interaction molecule 1 (STIM1) and STIM2. Mutations in ORAI1 and STIM1 genes that abolish SOCE cause a combined immunodeficiency (CID) syndrome that is accompanied by autoimmunity and non-immunological symptoms. OBJECTIVE: Molecular and immunological analysis of patients with CID, anhidrosis and ectodermal dysplasia of unknown etiology...
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29154938/assessments-of-cellular-melatonin-receptor-signaling-pathways-%C3%AE-arrestin-recruitment-receptor-internalization-and-impedance-variations
#19
Clémence Dupré, Olivier Bruno, Anne Bonnaud, Adeline Giganti, Olivier Nosjean, Céline Legros, Jean A Boutin
Melatonin receptors belong to the family of G-protein coupled receptors. Agonist-induced receptor activation is terminated with the recruitment of β-arrestin, which leads to receptor internalization. Furthermore, agonist binding induces a shift in cellular shape that translates into a change in the electric impedance of the cell. In the present study, we employed engineered cells to study these internalization-related processes in the context of the two melatonin receptors, MT1 and MT2. To assess these three receptor internalization-related functions and validate the results, we employed four classical ligands of melatonin receptors: the natural agonist melatonin; the super-agonist 2-iodo-melatonin and the two antagonists luzindole and 4-phenyl-2-propionamidotetralin...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154828/interaction-assessments-of-the-first-s-adenosylmethionine-competitive-inhibitor-and-the-essential-interacting-partner-methylosome-protein-50-with-protein-arginine-methyltransferase-5-by-combined-computational-methods
#20
Kongkai Zhu, Cheng-Shi Jiang, Junchi Hu, Xigong Liu, Xue Yan, Hongrui Tao, Cheng Luo, Hua Zhang
Protein arginine methyltransferase 5 (PRMT5) is the most promising anticancer target in PRMT family. In this study, based on the first S-adenosylmethionine (SAM) competitive small molecule inhibitor (17, compound number is from original paper) of PRMT5 reported in our recent paper, we determined the molecular mechanism of 17 interacting with PRMT5 by computational methods. Previously reported CMP5 was also thought of as a SAM competitive inhibitor of PRMT5, but the direct inhibition activity against PRMT5 at enzymatic level was not provided...
November 14, 2017: Biochemical and Biophysical Research Communications
keyword
keyword
16890
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"