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https://www.readbyqxmd.com/read/28320172/neuropathological-findings-from-an-autopsied-case-showing-posterior-reversible-encephalopathy-syndrome-like-neuroradiological-findings-associated-with-premedication-including-tacrolimus-for-autologous-peripheral-blood-stem-cell-transplantation
#1
Yuichi Hayashi, Akio Kimura, Hiroshi Nakamura, Maya Mimuro, Yasushi Iwasaki, Akira Hara, Mari Yoshida, Takashi Inuzuka
Posterior reversible encephalopathy syndrome (PRES) is diagnosed based on neuroradiological findings. Typically, PRES is reversible and presents with a good outcome; however, fatal outcomes have been reported. We report an autopsied case showing PRES-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation in a 28-year-old woman with a 2-year history of acute myeloid sarcoma/acute myeloid leukemia. Neurological examination revealed disturbed consciousness, muscle weakness in all extremities, and bilaterally diminished tendon reflexes...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320169/probable-zika-virus-associated-guillain-barr%C3%A3-syndrome-challenges-with-clinico-laboratory-diagnosis
#2
Eliza Miller, Zoe Becker, Daniel Shalev, Christopher T Lee, Comana Cioroiu, Kiran Thakur
A 55year old woman in New York City presented in May 2016 with progressive weakness, ataxia, paresthesia, and areflexia, shortly after returning from the Dominican Republic. Lumbar puncture revealed cytoalbuminological dissociation. Due to her recent travel, Zika-associated Guillain Barré syndrome (GBS) was suspected and she underwent evaluation for recent flavivirus exposure. Zika virus RNA was not detected in serum, but Zika virus immunoglobulin M (IgM) was detected in both serum and cerebrospinal fluid...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320053/management-of-colorectal-trauma-a-review
#3
REVIEW
Ju Yong Cheong, Anil Keshava
Traumatic colorectal injuries are common during times of military conflict, and major improvements in their care have arisen in such periods. Since World War II, many classification systems for colorectal trauma have been proposed, including (i) Flint Grading System; (ii) Penetrating Abdominal Trauma Index; (iii) Colonic/Rectal Injury Scale; and (iv) destructive/non-destructive colonic injuries. The primary goal of these classifications was to aid surgical management and, more particularly, to determine whether a primary repair or faecal diversion should be performed...
March 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28319889/the-evolution-of-environmental-metalloproteomics-over-the-last-15-years-through-bibliometric-techniques
#4
Rachel Ann Hauser-Davis, Renato Matos Lopes, Fábio Batista Mota, Josino Costa Moreira
Metalloproteomic studies in environmental scenarios are of significant value in elucidating metal uptake, trafficking, accumulation and metabolism linked to biomolecules in biological systems. The advent of this field occurred in the early 2000s, and it has since become an interesting and growing area of interdisciplinary research, although the number of publications in Environmental Metalloprotemics is still very low compared to other metallomic areas. In this context, the evolution of Environmental Metalloprotemics in the last decades was evaluated herein through the use of bibliometric techniques, identifying variables that may aid researchers in this area to form collaborative networks with established scientists in this regard, such as main authors, published articles, institutions, countries and established collaborations involved in academic research on this subject...
March 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28319525/crowdsourcing-to-evaluate-fundus-photographs-for-the-presence-of-glaucoma
#5
Xueyang Wang, Lucy I Mudie, Mani Baskaran, Ching-Yu Cheng, Wallace L Alward, David S Friedman, Christopher J Brady
PURPOSE: To assess the accuracy of crowdsourcing for grading optic nerve images for glaucoma using Amazon Mechanical Turk before and after training modules. MATERIALS AND METHODS: Images (n=60) from 2 large population studies were graded for glaucoma status and vertical cup-to-disc ratio (VCDR). In the baseline trial, users on Amazon Mechanical Turk (Turkers) graded fundus photos for glaucoma and VCDR after reviewing annotated example images. In 2 additional trials, Turkers viewed a 26-slide PowerPoint training or a 10-minute video training and passed a quiz before being permitted to grade the same 60 images...
March 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28319473/precision-medicine-in-asthma-the-role-of-bronchial-thermoplasty
#6
Amber J Oberle, Praveen Mathur
PURPOSE OF REVIEW: The inflammatory makeup of severe asthma is heterogeneous. Identification of the predominant cellular endotype via biomarkers can aid in the selection of more advanced therapies. This review is clinically focused on how to use these biomarkers to help select between biologic agents and/or bronchial thermoplasty. RECENT FINDINGS: Several Th2 biomarkers exist for the detection of eosinophilic disease; however, the best biomarker for clinical practice is debatable depending upon local resources...
March 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28319401/using-sound-to-study-the-effect-of-frothers-on-the-break-away-of-air-bubbles-at-an-underwater-capillary
#7
Pengbo Chu, Randolph Pax, Ronghao Li, Ray Langlois, James Andrew Finch
Frothers, a class of surfactants, are widely employed in froth flotation to aid the generation of small bubbles. Their action is commonly explained by their ability to hinder coalescence. There are occasional references suggesting that frother may also play a role in the initial break-up of the injected air mass. This work investigates the possible effect of frother on break-up by monitoring air bubbles produced quasi-statically at an underwater capillary. Under this condition, break-up is isolated from coalescence, and an impact of frothers on the detached bubble can be ascribed to an impact on break-up...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28319369/enhancement-of-the-thermoelectric-properties-of-fega3-type-structures-with-group-6-transition-metals-a-computational-exploration
#8
Benoît Boucher, Rabih Al Rahal Al Orabi, Bruno Fontaine, Yuri Grin, Régis Gautier, Jean-François Halet
The possible existence of group 6 TM3 compounds with T = Cr, Mo, W and M = Ga, In is investigated with the aid of density functional theory calculations. Their most probable crystal structure is expected to be of the FeGa3 type tetragonal space group P42/mnm. All compounds are computed to be semiconductors with a band gap ranging from 0.08 to 0.43 eV, at the modified Becke-Johnson level of theory. The thermoelectric properties are analyzed via calculations based on Boltzmann transport equation under a constant relaxation time approximation...
March 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28319221/fluorescent-chemical-probes-for-accurate-tumor-diagnosis-and-targeting-therapy
#9
REVIEW
Min Gao, Fabiao Yu, Changjun Lv, Jaebum Choo, Lingxin Chen
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells...
March 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28319213/comparison-of-the-marginal-fit-of-cobalt-chromium-metal-ceramic-crowns-fabricated-by-cad-cam-techniques-and-conventional-methods-at-three-production-stages
#10
Francisco Real-Voltas, Elisabeth Romano-Cardozo, Oscar Figueras-Alvarez, Magi Brufau-de Barbera, Josep Cabratosa-Termes
PURPOSE: The aim of this study was to compare the marginal fit of cobalt-chromium crowns fabricated using conventional casts and computer-aided design/computer-assisted manufacturing (CAD/CAM) techniques at three stages of production: metal coping, after porcelain firing, and after cementation. MATERIALS AND METHODS: A total of 80 metal-ceramic crowns were fabricated using four different techniques: lost wax casting, milling, laser sintering, and milling of a presintered metal block...
March 20, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28319197/the-hiv-care-cascade-japanese-perspectives
#11
Aikichi Iwamoto, Rikizo Taira, Yoshiyuki Yokomaku, Tomohiko Koibuchi, Mahbubur Rahman, Yoko Izumi, Kenji Tadokoro
Japan has been known as a low HIV-prevalence country with a concentrated epidemic among high-risk groups. However, it has not been determined whether Japan meets the 90-90-90 goals set by the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO). Moreover, to date, the HIV care cascade has not been examined. We estimated the total number of diagnosed people living with HIV/AIDS (PLWHA) (n = 22,840) based on legal reports to the Ministry of Health, Labour and Welfare by subtracting the number of foreigners who left Japan (n = 2,273) and deaths (n = 2,321) from the cumulative diagnosis report (n = 27,434)...
2017: PloS One
https://www.readbyqxmd.com/read/28319185/real-time-monitoring-of-human-blood-brain-barrier-disruption
#12
Vesa Kiviniemi, Vesa Korhonen, Jukka Kortelainen, Seppo Rytky, Tuija Keinänen, Timo Tuovinen, Matti Isokangas, Eila Sonkajärvi, Topi Siniluoto, Juha Nikkinen, Seppo Alahuhta, Osmo Tervonen, Taina Turpeenniemi-Hujanen, Teemu Myllylä, Outi Kuittinen, Juha Voipio
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma. Proper opening of the blood-brain barrier is crucial for the treatment, yet there are no means available for its real-time monitoring. The intact blood-brain barrier maintains a mV-level electrical potential difference between blood and brain tissue, giving rise to a measurable electrical signal at the scalp. Therefore, we used direct-current electroencephalography (DC-EEG) to characterize the spatiotemporal behavior of scalp-recorded slow electrical signals during blood-brain barrier opening...
2017: PloS One
https://www.readbyqxmd.com/read/28319131/a-direct-method-to-solve-optimal-knots-of-b-spline-curves-an-application-for-non-uniform-b-spline-curves-fitting
#13
Van Than Dung, Tegoeh Tjahjowidodo
B-spline functions are widely used in many industrial applications such as computer graphic representations, computer aided design, computer aided manufacturing, computer numerical control, etc. Recently, there exist some demands, e.g. in reverse engineering (RE) area, to employ B-spline curves for non-trivial cases that include curves with discontinuous points, cusps or turning points from the sampled data. The most challenging task in these cases is in the identification of the number of knots and their respective locations in non-uniform space in the most efficient computational cost...
2017: PloS One
https://www.readbyqxmd.com/read/28319106/a-systematic-review-on-the-impact-of-diabetes-mellitus-on-the-ocular-surface
#14
REVIEW
K Co Shih, K S-L Lam, L Tong
Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28319025/is-robot-assisted-laparoscopic-bilateral-extravesical-ureteral-reimplantation-associated-with-greater-morbidity-than-unilateral-surgery-a-comparative-analysis
#15
Arun K Srinivasan, Daniel Maass, Dhiren Shrivastava, Christopher J Long, Aseem R Shukla
INTRODUCTION: Voiding dysfunction after bilateral extravesical ureteral reimplantation for vesicoureteral reflux has long remained a concern. Robotic approach with improved visualization that enables focused and minimal dissection may help with this concern. OBJECTIVES: To compare postoperative outcomes after bilateral robot-assisted laparoscopic ureteral reimplantation to unilateral robot-assisted laparoscopic ureteral reimplantation. STUDY DESIGN: This was a retrospective study using data abstracted from an institutional review board-approved registry prospectively maintained at our institution since 2012...
March 6, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28318927/classical-versus-custom-orbital-wall-reconstruction-selected-factors-regarding-surgery-and-hospitalization
#16
Rafał Zieliński, Marta Malińska, Marcin Kozakiewicz
PURPOSE: Nowadays, in orbital wall reconstruction, maxillofacial surgeons have the possibility to treat patients in modern ways such as with individual implants. Nevertheless, conventional treatment including standard titanium mesh shaped during the surgical procedure is also widely used. The aim of this study was to compare the above methods of orbital wall reconstructions. MATERIALS AND METHODS: In the first group (39 cases), patients were treated by means of computer-aided design/computer-aided manufacturing (CAD/CAM) milled individual implants made of ultra-high-molecular-weight polyethylene, dioxide zirconium and rapid prototyping titanium mesh pre-bent on an ABS model made by a three-dimensional (3D) printer...
February 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28318681/updated-recommendations-on-the-use-of-hydroxychloroquine-in-dermatologic-practice
#17
REVIEW
Anthony P Fernandez
Hydroxychloroquine has unique immunomodulatory properties and an attractive adverse effect profile. Over the past 10 years, research has led to significant updates in clinical recommendations concerning the optimal use of hydroxychloroquine and monitoring of patients taking it. We discuss updated recommendations concerning hydroxychloroquine daily dosing, retinopathy screening, serologic monitoring, use in smokers, use in pregnant women, and adverse effect risk and monitoring. This review can hopefully serve as an aid to dermatologists and help ensure they continue using hydroxychloroquine safely and effectively...
March 16, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28318544/stereolithography-a-new-method-for-processing-dental-ceramics-by-additive-computer-aided-manufacturing
#18
Marion Dehurtevent, Lieven Robberecht, Jean-Christophe Hornez, Anthony Thuault, Etienne Deveaux, Pascal Béhin
OBJECTIVES: The aim of this study was to compare the physical and mechanical properties of stereolithography (SLA)- manufactured alumina ceramics of different composition to those of subtractive- manufactured ceramics and to produce suitable dental crown frameworks. METHODS: The physical and mechanical properties of a control and six experimental SLA ceramics prepared from slurries with small (S) and large (L) particles (0.46±0.03 and 1.56±0.04μm, respectively) and three dry matter contents (70%, 75%, 80%) were evaluated by dynamic rheometry, hydrostatic weighing, three3-point flexural strength measurements, and Weibull analyses, and by the micrometrics measurement of shrinkage ratio before and after the heat treatments...
March 16, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28318470/predicting-posttraumatic-stress-symptom-prevalence-and-local-distribution-after-an-earthquake-with-scarce-data
#19
Francisca Dussaillant, Mauricio Apablaza
BACKGROUND: After a major earthquake, the assignment of scarce mental health emergency personnel to different geographic areas is crucial to the effective management of the crisis. The scarce information that is available in the aftermath of a disaster may be valuable in helping predict where are the populations that are in most need. OBJECTIVE: The objectives of this study were to derive algorithms to predict posttraumatic stress (PTS) symptom prevalence and local distribution after an earthquake and to test whether there are algorithms that require few input data and are still reasonably predictive...
March 20, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28318318/non-guideline-recommended-prescribing-of-proton-pump-inhibitors-in-the-general-population
#20
Emma Mares-García, Antonio Palazón-Bru, Álvaro Martínez-Martín, David Manuel Folgado-de la Rosa, Avelino Pereira-Expósito, Vicente Francisco Gil-Guillén
OBJECTIVES: To determine the magnitude of non-guideline-recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in the general population, its associated factors and expense. METHODS: We undertook a cross-sectional observational study in three community pharmacies in a Spanish region in 2013 involving a total of 302 patients with a prescription for PPIs. The main variable was the NGRP of PPIs. Secondary variables were: gender, age, antidepressants, osteoporosis, osteoarthritis, prescription cost per month and total number of chronic diseases...
March 20, 2017: Current Medical Research and Opinion
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