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https://www.readbyqxmd.com/read/29046029/-is-it-possible-for-chronic-urticaria-diagnostic-approach-to-be-simplified-a-clinical-data-checklist
#1
Iván Chérrez-Ojeda, Karla Robles-Velasco, Pamela Bedoya-Riofrio, Peter Schmid-Grendelmeier, Sofía Chérrez, Florian Colbatzky, Ricardo Cardona, Pedro Barberan-Torres, Erick Calero, Juan Carlos Calderón, José I Larco, Annia Chérrez
BACKGROUND: Existing clinical guidelines do not offer an efficient alternative for the collection of data on relevant clinical traits during history and physical of the patient with chronic urticaria. OBJECTIVE: Our aim was to provide a clinical data checklist together with its guide to allow for thorough information to be obtained and for a physical exam that identifies the main features and triggering factors of the disease to be carried out. METHODS: A search was conducted for relevant literature on chronic urticaria in Medline, the Cochrane library and PubMed...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045894/from-oncogene-interference-to-neutrophil-immune-modulation
#2
Vincenzo Bronte
Oncogenes can aid tumor progression in a cancer cell-extrinsic way. In this issue of Immunity, Glodde et al. (2017) demonstrate that interference with c-MET tyrosine kinase receptor can relieve neutrophil-dependent immune suppression and unleash the effectiveness of immunotherapy even in the context of c-MET-independent tumors.
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045883/in-vitro-in-vivo-correlations-of-carbamazepine-nano-dispersions-for-application-in-formulation-development
#3
Zachary Warnken, Michael Puppolo, Justin Hughey, Iris Duarte, Susan Jansen-Varnum
During formulation development, efficiently integrating in vitro dissolution testing can significantly improve one's ability to estimate in vivo performance and aide in the selection of premier drug candidates. The concept of in vitro - in vivo relationship/correlation (IVIVR/IVIVC) has garnered significant attention from pharmaceutical scientists to predict expected bioavailability characteristics for drug substances and products. The current work illustrates a comparative evaluation of in vitro tests to access crystalline carbamazepine and various types of amorphous and crystalline dispersions of carbamazepine and Eudragit L100 produced by spray-drying, including a membrane-permeation dissolution methodology and non-sink dissolution...
October 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29045750/aging-and-hiv-related-caregiving-in-sub-saharan-africa-a-social-ecological-approach
#4
Jeon Small, Carolyn Aldwin, Paul Kowal, Somnath Chatterji, Rachel Pruchno
Background and Objectives: We reviewed the literature on older adults (OAs) who are caring for persons living with HIV/AIDS in sub-Saharan Africa (SSA), with the goal of adapting models of caregiver stress and coping to include culturally relevant and contextually appropriate factors specific to SSA, drawing on both life course and cultural capital theories. Research Design and Methods: A systematic literature search found 81 articles published between 1975 and 2016 which were reviewed using a narrative approach...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29045694/machine-learning-approaches-to-decipher-hormone-and-her2-receptor-status-phenotypes-in-breast-cancer
#5
Emmanuel S Adabor, George K Acquaah-Mensah
Breast cancer prognosis and administration of therapies are aided by knowledge of hormonal and HER2 receptor status. Breast cancer lacking estrogen receptors, progesterone receptors and HER2 receptors are difficult to treat. Regarding large data repositories such as The Cancer Genome Atlas, available wet-lab methods for establishing the presence of these receptors do not always conclusively cover all available samples. To this end, we introduce median-supplement methods to identify hormonal and HER2 receptor status phenotypes of breast cancer patients using gene expression profiles...
October 16, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29045665/dna-barcode-reference-library-for-the-african-citrus-triozid-trioza-erytreae-hemiptera-triozidae-vector-of-african-citrus-greening
#6
F M Khamis, I Rwomushana, L O Ombura, G Cook, S A Mohamed, C M Tanga, P W Nderitu, C Borgemeister, M Sétamou, T G Grout, S Ekesi, Stephen Garczynski
Citrus (Citrus spp.) production continues to decline in East Africa, particularly in Kenya and Tanzania, the two major producers in the region. This decline is attributed to pests and diseases including infestation by the African citrus triozid, Trioza erytreae (Del Guercio) (Hemiptera: Triozidae). Besides direct feeding damage by adults and immature stages, T. erytreae is the main vector of 'Candidatus Liberibacter africanus', the causative agent of Greening disease in Africa, closely related to Huanglongbing...
October 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29045438/gold-nanorod-reshaping-in-vitro-and-in-vivo-using-a-continuous-wave-laser
#7
David Harris-Birtill, Mohan Singh, Yu Zhou, Anant Shah, Pakatip Ruenraroengsak, Maria Elena Gallina, George B Hanna, Anthony E G Cass, Alexandra E Porter, Jeffrey Bamber, Daniel S Elson
Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical absorption spectral peak wavelength is determined by their size and shape. Photothermal therapy using GNRs is typically established using near infrared light as this allows sufficient penetration into the tumour matrix. Continuous wave (CW) lasers are the most commonly applied source of near infrared irradiation on GNRs for tumour photothermal therapy...
2017: PloS One
https://www.readbyqxmd.com/read/29045419/the-cost-of-mapping-trachoma-data-from-the-global-trachoma-mapping-project
#8
Guillaume Trotignon, Ellen Jones, Thomas Engels, Elena Schmidt, Deborah A McFarland, Colin K Macleod, Khaled Amer, Amadou A Bio, Ana Bakhtiari, Sarah Bovill, Amy H Doherty, Asad Aslam Khan, Mariamo Mbofana, Siobhain McCullagh, Tom Millar, Consity Mwale, Lisa A Rotondo, Angela Weaver, Rebecca Willis, Anthony W Solomon
BACKGROUND: The Global Trachoma Mapping Project (GTMP) was implemented with the aim of completing the baseline map of trachoma globally. Over 2.6 million people were examined in 1,546 districts across 29 countries between December 2012 and January 2016. The aim of the analysis was to estimate the unit cost and to identify the key cost drivers of trachoma prevalence surveys conducted as part of GTMP. METHODOLOGY AND PRINCIPAL FINDINGS: In-country and global support costs were obtained using GTMP financial records...
October 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29045410/patterns-and-rates-of-viral-evolution-in-hiv-1-subtype-b-infected-females-and-males
#9
Michael J Dapp, Kord M Kober, Lennie Chen, Dylan H Westfall, Kim Wong, Hong Zhao, Breana M Hall, Wenjie Deng, Thomas Sibley, Suvankar Ghorai, Katie Kim, Natalie Chen, Sarah McHugh, Lily Au, Mardge Cohen, Kathryn Anastos, James I Mullins
Biological sex differences affect the course of HIV infection, with untreated women having lower viral loads compared to their male counterparts but, for a given viral load, women have a higher rate of progression to AIDS. However, the vast majority of data on viral evolution, a process that is clearly impacted by host immunity and could be impacted by sex differences, has been derived from men. We conducted an intensive analysis of HIV-1 gag and env-gp120 evolution taken over the first 6-11 years of infection from 8 Women's Interagency HIV Study (WIHS) participants who had not received combination antiretroviral therapy (ART)...
2017: PloS One
https://www.readbyqxmd.com/read/29045189/effect-of-climatic-variables-on-abundance-and-dispersal-of-lecanosticta-acicola-spores-and-impact-of-defoliation-on-eastern-white-pine
#10
Stephen Wyka, Cameron Mcintyre, Cheryl Smith, Isabel Munck, Barret Rock, Heidi Asbjornsen, Kirk Broders
The disease complex white pine needle damage (WPND), first reported in 2006, has now escalated to an epidemic state across the northeastern U.S. Although this complex is composed of several fungal species, Lecanosticta acicola is considered to be the primary causal agent. Knowledge regarding the epidemiology, specific climatic factors that affect the spread of L. acicola on eastern white pine (Pinus strobus) in natural forest settings, and the potential risks repeated defoliation may have on tree health is limited...
October 18, 2017: Phytopathology
https://www.readbyqxmd.com/read/29045178/harmonizing-breast-cancer-screening-recommendations-metrics-and-accountability
#11
Cindy S Lee, Linda Moy, Sarah M Friedewald, Edward A Sickles, Debra L Monticciolo
OBJECTIVE: The purposes of this article are to summarize breast cancer screening recommendations and discuss their differences and similarities and to explain the differences between two national databases to aid in interpretation of their benchmarks. CONCLUSION: The American College of Radiology, American Cancer Society, and U.S. Preventive Services Task Force all agree that annual mammography beginning at age 40 saves the most lives, and all acknowledge a woman's right to choose when to begin and stop screening...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29045176/computer-aided-diagnosis-of-ground-glass-opacity-nodules-using-open-source-software-for-quantifying-tumor-heterogeneity
#12
Ming Li, Vivek Narayan, Ritu R Gill, Jyothi P Jagannathan, Maria F Barile, Feng Gao, Raphael Bueno, Jagadeesan Jayender
OBJECTIVE: The purposes of this study are to develop quantitative imaging biomarkers obtained from high-resolution CTs for classifying ground-glass nodules (GGNs) into atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC); to evaluate the utility of contrast enhancement for differential diagnosis; and to develop and validate a support vector machine (SVM) to predict the GGN type. MATERIALS AND METHODS: The heterogeneity of 248 GGNs was quantified using custom software...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29045126/characterization-of-three-druggable-hotspots-in-the-aurora-a-tpx2-interaction-using-biochemical-biophysical-and-fragment-based-approaches
#13
Patrick J McIntyre, Patrick M Collins, Lukáš Vrzal, Kristian Birchall, Laurence H Arnold, Chido Mpamhanga, Peter J Coombs, Selena G Burgess, Mark W Richards, Anja Winter, Václav Veverka, Frank von Delft, Andy Merritt, Richard Bayliss
The mitotic kinase Aurora-A and its partner protein TPX2 (Targeting Protein for Xenopus kinesin-like protein 2), are overexpressed in cancers and it has been proposed that they work together as an oncogenic holoenzyme. TPX2 is responsible for activating Aurora-A during mitosis, ensuring proper cell division. Disruption of the interface with TPX2 is therefore a potential target for novel anti-cancer drugs that exploit the increased sensitivity of cancer cells to mitotic stress. Here, we investigate the interface using co-precipitation assays and isothermal titration calorimetry to quantify the energetic contribution of individual residues of TPX2...
October 18, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29044932/right-heart-dysfunction-and-failure-in-heart-failure-with-preserved-ejection-fraction-mechanisms-and-management-position-statement-on-behalf-of-the-heart-failure-association-of-the-european-society-of-cardiology
#14
REVIEW
Thomas M Gorter, Dirk J van Veldhuisen, Johann Bauersachs, Barry A Borlaug, Jelena Celutkiene, Andrew J S Coats, Marisa G Crespo-Leiro, Marco Guazzi, Veli-Pekka Harjola, Stephane Heymans, Loreena Hill, Mitja Lainscak, Carolyn S P Lam, Lars H Lund, Alexander R Lyon, Alexandre Mebazaa, Christian Mueller, Walter J Paulus, Burkert Pieske, Massimo F Piepoli, Frank Ruschitzka, Frans H Rutten, Petar M Seferovic, Scott D Solomon, Sanjiv J Shah, Filippos Triposkiadis, Rolf Wachter, Carsten Tschöpe, Rudolf A de Boer
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients...
October 16, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29044894/immediate-implant-placement-and-provisionalization-following-tumor-resective-surgery-in-the-midfacial-region-a-case-series
#15
Nelson Fernandes, Jacobus van den Heever, Leanne Sykes
Surgical and prosthodontic restoration of the midfacial region following tumor resection has always posed a considerable challenge, as this area serves crucial functional and esthetic roles. Being diagnosed and subsequently treated for facial tumors can have an immense psychosocial impact on a patient, as the resulting defects are often disfiguring, and lead to an inability to masticate, swallow, and speak clearly. Provision of an immediate facial and dental prosthesis at the time of surgery can limit these side effects and help reduce mental duress on these patients and their families, as well as aid in the process of rehabilitation...
October 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29044559/discovery-and-characterization-of-novel-trans-spliced-products-of-human-polyoma-jc-virus-late-transcripts-from-pml-patients
#16
A Sami Saribas, Julia DeVoto, Akhil Golla, Hassen S Wollebo, Martyn K White, Mahmut Safak
Although the human neurotropic polyomavirus, JC virus (JCV), was isolated almost a half century ago, understanding the molecular mechanisms governing its biology remains highly elusive. JCV infects oligodendrocytes and astrocytes in the central nervous system (CNS) and causes a fatal brain disease known as progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals including AIDS. It has a small circular DNA genome (∼ 5 kb) and generates two primary transcripts from its early and late coding regions, producing several predicted alternatively spliced products mainly by cis-splicing...
October 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29044529/automated-identification-of-normoblast-cell-from-human-peripheral-blood-smear-images
#17
Dev Kumar DAS, Asok Kumar Maiti, Chandan Chakraborty
In this paper, we have presented a new computer-aided technique for automatic detection of nucleated red blood cells (NRBCs) or normoblast cell from peripheral blood smear image. The proposed methodology initiates with the localization of the nucleated cells by adopting multilevel thresholding approach in smear images. A novel colour space transformation technique has been introduced to differentiate nucleated blood cells [white blood cells (WBCs) and NRBC] from red blood cells (RBCs) by enhancing the contrast between them...
October 17, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/29044306/biomarkers-of-renal-recovery-after-acute-kidney-injury
#18
Sérgio Mina Gaião, José Artur Osório de Carvalho Paiva
Novel biomarkers can be suitable for early acute kidney injury diagnosis and the prediction of the need for dialysis. It remains unclear whether such biomarkers may also play a role in the prediction of recovery after established acute kidney injury or in aiding the decision of when to stop renal support therapy. PubMed, Web of Science and Google Scholar were searched for studies that reported on the epidemiology of renal recovery after acute kidney injury, the risk factors of recovery versus non-recovery after acute kidney injury, and potential biomarkers of acute kidney injury recovery...
July 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29043464/the-importance-of-early-detection-of-calcifications-associated-with-breast-cancer-in-screening
#19
J J Mordang, A Gubern-Mérida, A Bria, F Tortorella, R M Mann, M J M Broeders, G J den Heeten, N Karssemeijer
PURPOSE: The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. METHODS: From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses...
October 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29043237/hepcidin-and-iron-parameters-in-children-with-anemia-of-chronic-disease-and-iron-deficiency-anemia
#20
Gunjan Mahajan, Sunita Sharma, Jagdish Chandra, Anita Nangia
BACKGROUND: Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most prevalent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD and IDA. We also identified children with ACD who developed iron deficiency (ID). METHODS: The study was undertaken in anemic children with 30 cases each of ACD and IDA along with 30 age and sex-matched controls...
September 2017: Blood Research
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