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https://www.readbyqxmd.com/read/28732282/proficient-use-of-low-spatial-frequencies-facilitates-face-memory-but-shows-protracted-maturation-throughout-adolescence
#1
Judith C Peters, Chantal Kemner
Face perception is characterized by configural processing, which depends on visual information in the low spatial frequency (LSF) ranges. However, it is unclear whether LSF content is equally important for face memory. The present study investigated how face information in the low and high SF range plays a role in the configural encoding of faces for short-term and long-term recall. Moreover, we examined how SF-dependent face memorization develops in female adolescence, by comparing children (9-10-year-olds), adolescents (12-13-year-olds and 15-16-year-olds), and young adults (21-32-year-olds)...
July 18, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28732212/ualcan-a-portal-for-facilitating-tumor-subgroup-gene-expression-and-survival-analyses
#2
Darshan S Chandrashekar, Bhuwan Bashel, Sai Akshaya Hodigere Balasubramanya, Chad J Creighton, Israel Ponce-Rodriguez, Balabhadrapatruni V S K Chakravarthi, Sooryanarayana Varambally
Genomics data from The Cancer Genome Atlas (TCGA) project has led to the comprehensive molecular characterization of multiple cancer types. The large sample numbers in TCGA offer an excellent opportunity to address questions associated with tumo heterogeneity. Exploration of the data by cancer researchers and clinicians is imperative to unearth novel therapeutic/diagnostic biomarkers. Various computational tools have been developed to aid researchers in carrying out specific TCGA data analyses; however there is need for resources to facilitate the study of gene expression variations and survival associations across tumors...
July 18, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28732028/the-individual-and-contextual-determinants-of-the-use-of-telemedicine-a-descriptive-study-of-the-perceptions-of-senegal-s-physicians-and-telemedicine-projects-managers
#3
Birama Apho Ly, Ronald Labonté, Ivy Lynn Bourgeault, Mbayang Ndiaye Niang
Telemedicine is considered to be an effective strategy to aid in the recruitment and retention of physicians in underserved areas and, in doing so, improve access to healthcare. Telemedicine's use, however, depends on individual and contextual factors. Using a mixed methods design, we studied these factors in Senegal based on a micro, meso and macro framework. A quantitative questionnaire administered to 165 physicians working in public hospitals and 151 physicians working in district health centres was used to identify individual (micro) factors...
2017: PloS One
https://www.readbyqxmd.com/read/28731896/freehand-versus-guided-surgery-factors-influencing-accuracy-of-dental-implant-placement
#4
William Choi, Bao-Chau Nguyen, Andrew Doan, Sabine Girod, Brice Gaudilliere, Dyani Gaudilliere
INTRODUCTION: Patient anatomy, practitioner experience, and surgical approach are all factors that influence implant accuracy. However, the relative importance of each factor is poorly understood. The present study aimed to identify which factors most critically determine implant accuracy to aid the practitioner in case selection for guided versus freehand surgery. METHODS: One practitioner's ideal implant angulation and position was compared with his achieved position radiographically for 450 implants placed using a conventional freehand method...
August 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28731857/cytomcs-a-multiple-maximum-common-subgraph-detection-tool-for-cytoscape
#5
Simon J Larsen, Jan Baumbach
Comparative analysis of biological networks is a major problem in computational integrative systems biology. By computing the maximum common edge subgraph between a set of networks, one is able to detect conserved substructures between them and quantify their topological similarity. To aid such analyses we have developed CytoMCS, a Cytoscape app for computing inexact solutions to the maximum common edge subgraph problem for two or more graphs. Our algorithm uses an iterative local search heuristic for computing conserved subgraphs, optimizing a squared edge conservation score that is able to detect not only fully conserved edges but also partially conserved edges...
July 21, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28731838/neuroprotection-in-glaucoma-animal-models-and-clinical-trials
#6
Mohammadali Almasieh, Leonard A Levin
Glaucoma is a progressive neurodegenerative disease that frequently results in irreversible blindness. Glaucoma causes death of retinal ganglion cells (RGCs) and their axons in the optic nerve, resulting in visual field deficits and eventual loss of visual acuity. Glaucoma is a complex optic neuropathy, and a successful strategy for its treatment requires not only better management of known risk factors such as elevated intraocular pressure and the development of improved tools for detecting RGC injury but also treatments that address this injury (i...
July 21, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28731817/infrared-spectrometer-for-exomars-a-mast-mounted-instrument-for-the-rover
#7
Oleg I Korablev, Yurii Dobrolensky, Nadezhda Evdokimova, Anna A Fedorova, Ruslan O Kuzmin, Sergei N Mantsevich, Edward A Cloutis, John Carter, Francois Poulet, Jessica Flahaut, Andrew Griffiths, Matthew Gunn, Nicole Schmitz, Javier Martín-Torres, Maria-Paz Zorzano, Daniil S Rodionov, Jorge L Vago, Alexander V Stepanov, Andrei Yu Titov, Nikita A Vyazovetsky, Alexander Yu Trokhimovskiy, Alexander G Sapgir, Yurii K Kalinnikov, Yurii S Ivanov, Alexei A Shapkin, Andrei Yu Ivanov
ISEM (Infrared Spectrometer for ExoMars) is a pencil-beam infrared spectrometer that will measure reflected solar radiation in the near infrared range for context assessment of the surface mineralogy in the vicinity of the ExoMars rover. The instrument will be accommodated on the mast of the rover and will be operated together with the panoramic camera (PanCam), high-resolution camera (HRC). ISEM will study the mineralogical and petrographic composition of the martian surface in the vicinity of the rover, and in combination with the other remote sensing instruments, it will aid in the selection of potential targets for close-up investigations and drilling sites...
June 2017: Astrobiology
https://www.readbyqxmd.com/read/28731796/bees-without-flowers-before-peak-bloom-diverse-native-bees-find-insect-produced-honeydew-sugars
#8
Joan M Meiners, Terry L Griswold, David J Harris, S K Morgan Ernest
Bee foragers respond to complex visual, olfactory, and extrasensory cues to optimize searches for floral rewards. Their abilities to detect and distinguish floral colors, shapes, volatiles, and ultraviolet signals and even gauge nectar availability from changes in floral humidity or electric fields are well studied. Bee foraging behaviors in the absence of floral cues, however, are rarely considered. We observed 42 species of wild bees visiting inconspicuous, nonflowering shrubs during early spring in a protected Mediterranean habitat...
August 2017: American Naturalist
https://www.readbyqxmd.com/read/28731778/a-pharmacologic-algorithm-for-youth-who-are-at-high-risk-for-bipolar-disorder
#9
Christopher D Schneck, Kiki D Chang, Manpreet K Singh, Melissa P DelBello, David J Miklowitz
OBJECTIVE: Depression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD. METHODS: Subjects were 40 youth (mean 12...
July 21, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28731684/the-binding-mode-of-n-hydroxyamidines-to-indoleamine-2-3-dioxygenase-1-ido1
#10
Ute Friederike Röhrig, Vincent Zoete, Olivier Michielin
Indoleamine 2,3-dioxygenase 1 (IDO1) is an important target in cancer immunotherapy. The most advanced clinical compound, epacadostat (INCB024360), binds to the heme cofactor of IDO1 through a N-hydroxyamidine function. Conflicting binding modes have recently been proposed, reporting iron binding either through the hydroxyamidine oxygen or nitrogen atoms. Here, we use quantum chemical calculations, docking, and QM/MM calculations based on available X-ray data to resolve this issue and to propose a physically meaningful binding mode...
July 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/28731587/reversible-pressure-controlled-depolymerization-of-a-copper-ii-containing-coordination-polymer
#11
Jack Kay Clegg, Aidan Brock, Katrina Jolliffe, Simon Parsons, Leonard Lindoy, Peter Tasker, Fraser White
A unique pressure-induced Cu-N bond breaking/bond forming reaction is reported. The variation of pressure on a single crystal of a one-dimensional copper(II)-containing coordination polymer (Cu2L2(1-methylpiperazine)2]n, where H2L is 1,1'-(1,3-phenylene)-bis(4,4-dimethylpentane-1,3-dione)), was monitored using single crystal X-ray diffraction with the aid of a diamond anvil cell. At a very low elevated pressure (~0.05 GPa) a remarkable reversible phase change was observed. The phase change results in the depolymerization of the material through the cleavage and formation of axial Cu-N bonds as well as "ring flips" of individual axially coordinated 1-methylpiperazine ligands...
July 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28731487/intraoperative-fluoroscopy-with-a-direct-anterior-approach-reduces-variation-in-acetabular-cup-abduction-angle
#12
Gens P Goodman, Nitin Goyal, Nancy L Parks, Robert H Hopper, William G Hamilton
INTRODUCTION: The purpose of this study was to compare acetabular cup position for 2 cohorts of total hip arthroplasty (THA) patients who had a direct anterior approach. METHODS: 100 THA cases were performed with an anterior approach using intraoperative fluoroscopy (IF) to aid in cup positioning. Another group of 100 cases underwent THA with an anterior approach without the use of any fluoroscopy. Postoperative abduction and anteversion angles were measured using Martell's hip analysis software...
July 19, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28731422/frailty-in-men-living-with-hiv-a-cross-sectional-comparison-of-three-frailty-instruments
#13
Hui-Ling Yeoh, Allen Cheng, Clovis Palmer, Suzanne M Crowe, Jennifer F Hoy
BACKGROUND: Potent antiretroviral treatment has resulted in near normal life expectancy for people living with HIV. Consequently, there is an increased focus on comorbidities, frailty and quality of life. METHODS: We assessed and compared the prevalence of frailty, associated factors and relationship with quality of life in older Australian men living with HIV in a cross-sectional study using three frailty measurements. The Frailty Phenotype, Frailty Index, and Edmonton Frail Scale were applied to 93 HIV-infected men aged over 50 years, on antiretroviral therapy...
July 21, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28731373/efficacy-of-1-metformin-gel-in-moderate-and-severe-chronic-periodontitis-subjects-a-randomized-controlled-clinical-trial
#14
A R Pradeep, Kaushik Patnaik, Kanika Nagpal, Shruti Karvekar, C N Guruprasad, K M Kumaraswamy
BACKGROUND: To investigate efficacy of MF 1 % gel as, as an adjunct to scaling and root planing (SRP) in treatment of moderate and severe chronic periodontitis subjects. METHODS: Seventy subjects were categorized into two treatment groups: SRP plus 1% MF and SRP plus placebo. Clinical parameters were recorded at baseline, 3, 6 and 9 months; they included plaque index (PI), modified sulcus bleeding index (mSBI), pocket depth (PD), and clinical attachment level (CAL)...
July 21, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28731357/visible-light-induced-and-oxygen-promoted-oxidative-cyclization-of-aromatic-enamines-for-the-synthesis-of-quinolines-derivatives
#15
Xiao-Feng Xia, Guo-Wei Zhang, Dawei Wang, Su-Li Zhu
The dual transition metal-visible light photoredox catalysis for the synthesis of quinoline derivatives by using dioxygen as an oxygen source is developed. By using visible light, the direct oxidative cyclization of aromatic enamines with alkynes or alkenes can be achieved at mild conditions with an aide of copper or palladium catalysts, and a variety of multi-substituted quinoline derivatives could be obtained in good to moderate yields under mild reaction conditions.
July 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28731291/critical-questions-advancing-the-health-of-female-veterans
#16
Lisa Muirhead, Priscilla Hall, Cedrella Jones-Taylor, Gari D Clifford, Tasha Felton-Williams, Kathy Williams
PURPOSE: Women are the fastest growing Veteran population in the United States and many receive all or part of their health care outside of the Department of Veterans Affairs (VA). The purpose of this article is to review the healthcare issues of women Veterans and discuss implications for care. DATA SOURCES: Review of selected literature, VA resources and guidelines, and expert opinion. CONCLUSIONS: Few providers are aware of the impact military service has on the health of women and fail to ask the all-important question, "Have you served in the military?" Recognizing women's military service can reveal important information that can answer perplexing clinical questions, aid in designing comprehensive plans of care, and enable women to receive the assistance needed to address complex physical and psychosocial issues to improve the quality of their lives...
July 21, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28731184/bufalin-reverses-acquired-drug-resistance-by-inhibiting-stemness-in-colorectal-cancer-cells
#17
Jian Sun, Ke Xu, Yanyan Qiu, Hong Gao, Jianhua Xu, Qingfeng Tang, Peihao Yin
Drug resistance is an obstacle to chemotherapy in tumor patients. Recent studies have shown that the high stemness of cancer cells may be induced by chemotherapeutic drugs, which is correlated with drug resistance. In the present study, we investigated the effects of bufalin on the stemness of colorectal cancer. We found that cisplatin could induce high stemness through the tumorsphere formation assay in vitro and in vivo in the colorectal cancer cell lines HCT116 and LoVo. In addition, cisplatin-treated tumorsphere cells showed drug‑resistant properties...
July 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28731128/lncrna-expression-character-associated-with-ischemic-reperfusion-injury
#18
Xiaowei Wu, Hongyi Zhu, Suhua Zhu, Maojuan Hao, Qingping Li
Ischemic reperfusion injury (IRI) contributes to morbidity and mortality worldwide and results in a poor outcome for patients suffering from myocardial infarction. Ischemic post‑conditioning (IPostC), consisting of one or several brief periods of ischemia and reperfusion, generates powerful protection against IRI. The mechanism of IPostC initiation and development has previously been investigated, however still remains to be fully elucidated. Notably, long non‑coding (lnc) RNAs have previously been demonstrated to be important in cardiovascular diseases...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28731126/mir%C3%A2-132-in-atrial-fibrillation-directly-targets-connective-tissue-growth-factor
#19
Gang Qiao, Dongsheng Xia, Zhaoyun Cheng, Guobao Zhang
Atrial fibrillation (AF) is the most frequently occurring, persistent cardiac arrhythmia, and the hallmark of AF‑dependent structural remodeling is atrial fibrosis. Connective tissue growth factor (CTGF) is important in the process of fibrosis. The association between miRNA and CTGF in AF‑dependent fibrosis remains to be elucidated. The present study aimed to determine if microRNA (miR)‑132 was able to regulate CTGF with an anti‑fibrotic effect in AF. A total of ten dogs or patients were assigned to control (n=4) and AF groups (n=6)...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730938/stratum-corneum-modulation-by-chemical-enhancers-and-lipid-nanostructures-implications-for-transdermal-drug-delivery
#20
Mudra Saurabh Kapoor, Shruti GuhaSarkar, Rinti Banerjee
Skin is the outermost and largest protective covering of the body. The uppermost layer of the skin, stratum corneum also called the horny layer is composed of keratin-filled cells covered by a lipid matrix which shields the skin from physical and chemical entrants. The lipid lamellar structure comprises of ceramides, cholesterol, fatty acids and proteins. Chemical enhancers that mimic the lamellar chemistry, reversibly fluidize the latter can be utilized for enhancing transport of cargo across the epidermis into the dermis...
July 2017: Therapeutic Delivery
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