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JOURNAL ARTICLE
Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan R I Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polimanti, Cindy Aaronson, Ananda B Amstadter, Soren B Andersen, Ole A Andreassen, Paul A Arbisi, Allison E Ashley-Koch, S Bryn Austin, Esmina Avdibegoviç, Dragan Babić, Silviu-Alin Bacanu, Dewleen G Baker, Anthony Batzler, Jean C Beckham, Sintia Belangero, Corina Benjet, Carisa Bergner, Linda M Bierer, Joanna M Biernacka, Laura J Bierut, Jonathan I Bisson, Marco P Boks, Elizabeth A Bolger, Amber Brandolino, Gerome Breen, Rodrigo Affonseca Bressan, Richard A Bryant, Angela C Bustamante, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Anders D Børglum, Sigrid Børte, Leah Cahn, Joseph R Calabrese, Jose Miguel Caldas-de-Almeida, Chris Chatzinakos, Sheraz Cheema, Sean A P Clouston, Lucía Colodro-Conde, Brandon J Coombes, Carlos S Cruz-Fuentes, Anders M Dale, Shareefa Dalvie, Lea K Davis, Jürgen Deckert, Douglas L Delahanty, Michelle F Dennis, Frank Desarnaud, Christopher P DiPietro, Seth G Disner, Anna R Docherty, Katharina Domschke, Grete Dyb, Alma Džubur Kulenović, Howard J Edenberg, Alexandra Evans, Chiara Fabbri, Negar Fani, Lindsay A Farrer, Adriana Feder, Norah C Feeny, Janine D Flory, David Forbes, Carol E Franz, Sandro Galea, Melanie E Garrett, Bizu Gelaye, Joel Gelernter, Elbert Geuze, Charles F Gillespie, Slavina B Goleva, Scott D Gordon, Aferdita Goçi, Lana Ruvolo Grasser, Camila Guindalini, Magali Haas, Saskia Hagenaars, Michael A Hauser, Andrew C Heath, Sian M J Hemmings, Victor Hesselbrock, Ian B Hickie, Kelleigh Hogan, David Michael Hougaard, Hailiang Huang, Laura M Huckins, Kristian Hveem, Miro Jakovljević, Arash Javanbakht, Gregory D Jenkins, Jessica Johnson, Ian Jones, Tanja Jovanovic, Karen-Inge Karstoft, Milissa L Kaufman, James L Kennedy, Ronald C Kessler, Alaptagin Khan, Nathan A Kimbrel, Anthony P King, Nastassja Koen, Roman Kotov, Henry R Kranzler, Kristi Krebs, William S Kremen, Pei-Fen Kuan, Bruce R Lawford, Lauren A M Lebois, Kelli Lehto, Daniel F Levey, Catrin Lewis, Israel Liberzon, Sarah D Linnstaedt, Mark W Logue, Adriana Lori, Yi Lu, Benjamin J Luft, Michelle K Lupton, Jurjen J Luykx, Iouri Makotkine, Jessica L Maples-Keller, Shelby Marchese, Charles Marmar, Nicholas G Martin, Gabriela A Martínez-Levy, Kerrie McAloney, Alexander McFarlane, Katie A McLaughlin, Samuel A McLean, Sarah E Medland, Divya Mehta, Jacquelyn Meyers, Vasiliki Michopoulos, Elizabeth A Mikita, Lili Milani, William Milberg, Mark W Miller, Rajendra A Morey, Charles Phillip Morris, Ole Mors, Preben Bo Mortensen, Mary S Mufford, Elliot C Nelson, Merete Nordentoft, Sonya B Norman, Nicole R Nugent, Meaghan O'Donnell, Holly K Orcutt, Pedro M Pan, Matthew S Panizzon, Gita A Pathak, Edward S Peters, Alan L Peterson, Matthew Peverill, Robert H Pietrzak, Melissa A Polusny, Bernice Porjesz, Abigail Powers, Xue-Jun Qin, Andrew Ratanatharathorn, Victoria B Risbrough, Andrea L Roberts, Alex O Rothbaum, Barbara O Rothbaum, Peter Roy-Byrne, Kenneth J Ruggiero, Ariane Rung, Heiko Runz, Bart P F Rutten, Stacey Saenz de Viteri, Giovanni Abrahão Salum, Laura Sampson, Sixto E Sanchez, Marcos Santoro, Carina Seah, Soraya Seedat, Julia S Seng, Andrey Shabalin, Christina M Sheerin, Derrick Silove, Alicia K Smith, Jordan W Smoller, Scott R Sponheim, Dan J Stein, Synne Stensland, Jennifer S Stevens, Jennifer A Sumner, Martin H Teicher, Wesley K Thompson, Arun K Tiwari, Edward Trapido, Monica Uddin, Robert J Ursano, Unnur Valdimarsdóttir, Miranda Van Hooff, Eric Vermetten, Christiaan H Vinkers, Joanne Voisey, Yunpeng Wang, Zhewu Wang, Monika Waszczuk, Heike Weber, Frank R Wendt, Thomas Werge, Michelle A Williams, Douglas E Williamson, Bendik S Winsvold, Sherry Winternitz, Christiane Wolf, Erika J Wolf, Yan Xia, Ying Xiong, Rachel Yehuda, Keith A Young, Ross McD Young, Clement C Zai, Gwyneth C Zai, Mark Zervas, Hongyu Zhao, Lori A Zoellner, John-Anker Zwart, Terri deRoon-Cassini, Sanne J H van Rooij, Leigh L van den Heuvel, Murray B Stein, Kerry J Ressler, Karestan C Koenen
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new)...
April 18, 2024: Nature Genetics
#22
JOURNAL ARTICLE
Megan Demars, Tim McDowell, Justin Renaud, Andrew Scott, Michael Fruci, Edward Topp
Some antibiotics are used for the treatment of various bacterial crop diseases, and there is a concern that this practice may represent a selection pressure that increases the reservoir of antibiotic resistance carried by bacteria in crop production systems. Since the 1950s the aminoglycoside antibiotic streptomycin has been widely used for the treatment of some bacterial crop diseases such as fire blight in apples and pears. Following application, the time that bacteria will be exposed to the antibiotic, and therefore the pressure for selection of resistance, will vary according to the environmental persistence of the antibiotic...
April 16, 2024: Science of the Total Environment
#23
JOURNAL ARTICLE
Massimo Baudo, Serge Sicouri, Yoshiyuki Yamashita, Khalid Ridwan, Amer Kadri, Scott M Goldman, Roberto Rodriguez, Eric M Gnall, Paul M Coady, Michael J Reardon, Hemal Gada, William A Gray, Basel Ramlawi
Patients with small aortic annuli (SAA) pose a challenge in aortic valve replacement patients due to potential for prosthesis-patient mismatch (PPM). The objective of this study was to compare clinical and hemodynamic outcomes of self-expandable valves (SEV) versus balloon-expandable valves (BEV) transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis and SAA. All patients who underwent TAVI for severe native aortic stenosis with a SAA between January 2018 and December 2022 were retrospectively included in the study from a single center...
April 16, 2024: American Journal of Cardiology
#24
JOURNAL ARTICLE
Target Delineation in Postoperative Radiotherapy for Head and Neck Cancer after Flap Reconstruction.
Xuguang Scott Chen, David Sher, Christopher Blake Sullivan, Michael C Repka, Colette Shen, Bhisham Chera
No abstract text is available yet for this article.
April 16, 2024: Practical Radiation Oncology
#25
JOURNAL ARTICLE
Quan Sun, Yingxi Yang, Jonathan D Rosen, Jiawen Chen, Xihao Li, Wyliena Guan, Min-Zhi Jiang, Jia Wen, Rhonda G Pace, Scott M Blackman, Michael J Bamshad, Ronald L Gibson, Garry R Cutting, Wanda K O'Neal, Michael R Knowles, Charles Kooperberg, Alexander P Reiner, Laura M Raffield, April P Carson, Stephen S Rich, Jerome I Rotter, Ruth J F Loos, Eimear Kenny, Byron C Jaeger, Yuan-I Min, Christian Fuchsberger, Yun Li
Since genotype imputation was introduced, researchers have been relying on the estimated imputation quality from imputation software to perform post-imputation quality control (QC). However, this quality estimate (denoted as Rsq) performs less well for lower-frequency variants. We recently published MagicalRsq, a machine-learning-based imputation quality calibration, which leverages additional typed markers from the same cohort and outperforms Rsq as a QC metric. In this work, we extended the original MagicalRsq to allow cross-cohort model training and named the new model MagicalRsq-X...
April 9, 2024: American Journal of Human Genetics
#26
JOURNAL ARTICLE
Cristina Jaén, Christopher Maute, Scott Mackin, Monica R Camacho, Diana Truran, Rachel Nosheny, Michael W Weiner, Pamela Dalton
BACKGROUND: Early identification of deficits in our ability to perceive odors is important as many normal (i.e., aging) and pathological (i.e., sinusitis, viral, neurodegeneration) processes can result in diminished olfactory function. To realistically enable population-level measurements of olfaction, validated olfaction tests must be capable of being administered outside the research laboratory and clinical setting. AIM: The purpose of this study was to determine the feasibility of remotely testing olfactory performance using a test that was developed with funding from the National Institutes of Health as part of a ready-to-use, non-proprietary set of measurements useful for epidemiologic studies (NIH Toolbox Odor ID Test)...
2024: PloS One
#27
JOURNAL ARTICLE
Michael G Brandel, Jillian H Plonsker, Robert C Rennert, Gautam Produturi, Megana Saripella, Arvin R Wali, Carson McCann, Vijay M Ravindra, David R Santiago-Dieppa, J Scott Pannell, Jeffrey A Steinberg, Alexander A Khalessi, Michael L Levy
INTRODUCTION: Pediatric intracranial aneurysms (IAs) are rare and have distinct clinical profiles compared to adult IAs. They differ in location, size, morphology, presentation, and treatment strategies. We present our experience with pediatric IAs over an 18-year period using surgical and endovascular treatments and review the literature to identify commonalities in epidemiology, treatment, and outcomes. METHODS: We identified all patients < 20 years old who underwent treatment for IAs at our institution between 2005 and 2020...
April 18, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#28
JOURNAL ARTICLE
Michael W K Fong, Eleanor Stephens, Alice Brockington, Jayaganth Jayabal, Shona Scott, Tony Zhang, Rhonda Litchfield, Erica Beilharz, Stuart R Dalziel, Peter Jones, Kim Yates, Vanessa Thornton, Peter S Bergin
OBJECTIVE: Determination of the real-world performance of a health care system in the treatment of status epilepticus (SE). METHODS: Prospective, multicenter population-based study of SE in Auckland, New Zealand (NZ) over 1 year, with data recorded in the EpiNet database. Focus on treatment patterns and determinants of SE duration and 30-day mortality. The incidence, etiology, ethnic discrepancies, and seizure characteristics of this cohort have been published previously...
April 18, 2024: Epilepsia
#29
REVIEW
Dawood Sayed, Timothy Ray Deer, Jonathan M Hagedorn, Asim Sayed, Ryan S D'Souza, Christopher M Lam, Nasir Khatri, Zohra Hussaini, Scott G Pritzlaff, Newaj Mohammad Abdullah, Vinicius Tieppo Francio, Steven Michael Falowski, Yussr M Ibrahim, Mark N Malinowski, Ryan R Budwany, Natalie Holmes Strand, Kamil M Sochacki, Anuj Shah, Tyler M Dunn, Morad Nasseri, David W Lee, Leonardo Kapural, Marshall David Bedder, Erika A Petersen, Kasra Amirdelfan, Michael E Schatman, Jay Samuel Grider
INTRODUCTION: Painful diabetic neuropathy (PDN) is a leading cause of pain and disability globally with a lack of consensus on the appropriate treatment of those suffering from this condition. Recent advancements in both pharmacotherapy and interventional approaches have broadened the treatment options for PDN. There exists a need for a comprehensive guideline for the safe and effective treatment of patients suffering from PDN. OBJECTIVE: The SWEET Guideline was developed to provide clinicians with the most comprehensive guideline for the safe and appropriate treatment of patients suffering from PDN...
2024: Journal of Pain Research
#30
JOURNAL ARTICLE
Scott Boebinger, Aiden Payne, Giovanni Martino, Kennedy Kerr, Jasmine Mirdamadi, J Lucas McKay, Michael Borich, Lena Ting
The role of the cortex in shaping automatic whole-body motor behaviors such as walking and balance is poorly understood. Gait and balance are typically mediated through subcortical circuits, with the cortex becoming engaged as needed on an individual basis by task difficulty and complexity. However, we lack a mechanistic understanding of how increased cortical contribution to whole-body movements shapes motor output. Here we use reactive balance recovery as a paradigm to identify relationships between hierarchical control mechanisms and their engagement across balance tasks of increasing difficulty in young adults...
April 17, 2024: PLoS Computational Biology
#31
JOURNAL ARTICLE
Clayton T Lamb, Sara Williams, Stan Boutin, Michael Bridger, Deborah Cichowski, Kristina Cornhill, Craig DeMars, Melanie Dickie, Bevan Ernst, Adam Ford, Michael P Gillingham, Laura Greene, Douglas C Heard, Mark Hebblewhite, Dave Hervieux, Mike Klaczek, Bruce N McLellan, R Scott McNay, Lalenia Neufeld, Barry Nobert, J Joshua Nowak, Agnès Pelletier, Aaron Reid, Anne-Marie Roberts, Mike Russell, Dale Seip, Caroline Seip, Carolyn Shores, Robin Steenweg, Shane White, Heiko U Wittmer, Mark Wong, Kathryn L Zimmerman, Robert Serrouya
Habitat loss is affecting many species, including the southern mountain caribou (Rangifer tarandus caribou) population in western North America. Over the last half century, this threatened caribou population's range and abundance have dramatically contracted. An integrated population model was used to analyze 51 years (1973-2023) of demographic data from 40 southern mountain caribou subpopulations to assess the effectiveness of population-based recovery actions at increasing population growth. Reducing potential limiting factors on threatened caribou populations offered a rare opportunity to identify the causes of decline and assess methods of recovery...
April 17, 2024: Ecological Applications
#32
JOURNAL ARTICLE
Sun Hee Kim, Sangdon Han, Jian Zhao, Shimiao Wang, Ana Karin Kusnetzow, Greg Reinhart, Melissa A Fowler, Stacy Markison, Michael Johns, Rosa Luo, R Scott Struthers, Yunfei Zhu, Stephen F Betz
A novel class of nonpeptide melanocortin type 2 receptor (MC2R) antagonists was discovered through modification of known nonpeptide MC4R ligands. Structure-activity relationship (SAR) studies led to the discovery of 17h (CRN04894), a highly potent and subtype-selective first-in-class MC2R antagonist, which demonstrated remarkable efficacy in a rat model of adrenocorticotrophic hormone (ACTH)-stimulated corticosterone secretion. Oral administration of 17h suppressed ACTH-stimulated corticosterone secretion in a dose-dependent manner at doses ≥3 mg/kg...
April 11, 2024: ACS Medicinal Chemistry Letters
#33
JOURNAL ARTICLE
Colby R Slezak, Erik J Blomberg, Amber M Roth, Liam A Berigan, Alexander C Fish, Rachel Darling, Sarah J Clements, Greg Balkcom, Bobbi Carpenter, Gary Costanzo, Jeffrey Duguay, Clayton L Graham, William Harvey, Michael Hook, Douglas L Howell, Seth Maddox, Shawn W Meyer, Theodore C Nichols, J Bruce Pollard, Christian Roy, Joshua C Stiller, Jacob N Straub, Mathieu Tetreault, Reina Tyl, Lisa Williams, Jennifer E Kilburn, Scott R McWilliams
Conventional life-history theory predicts that energy-demanding events such as reproduction and migration must be temporally segregated to avoid resource limitation. Here, we provide, to our knowledge, the first direct evidence of 'itinerant breeding' in a migratory bird, an incredibly rare breeding strategy (less than 0.1% of extant bird species) that involves the temporal overlap of migratory and reproductive periods of the annual cycle. Based on GPS-tracking of over 200 female American woodcock, most female woodcock (greater than 80%) nested more than once (some up to six times) with short re-nest intervals, and females moved northwards on average 800 km between first and second nests, and then smaller distances ( ca 200+ km) between subsequent nesting attempts...
April 30, 2024: Proceedings. Biological Sciences
#34
EDITORIAL
Christopher H Hawkes, Gavin Giovannoni, Jeanette Lechner-Scott, Michael Levy, Ann Yeh
No abstract text is available yet for this article.
April 15, 2024: Multiple Sclerosis and related Disorders
#35
JOURNAL ARTICLE
Sindia M Sosdian, Michael K Gagan, Danny H Natawidjaja, Alena K Kimbrough, Bambang W Suwargadi, Hamdi Rifai, Heather Scott-Gagan, Dudi Prayudi, Imam Suprihanto, Wahyoe S Hantoro
On 28 March 2005, the Indonesian islands of Nias and Simeulue experienced a powerful Mw 8.6 earthquake and coseismic uplift and subsidence. In areas of coastal uplift (up to ~ 2.8 m), fringing reef coral communities were killed by exposure, while deeper corals that survived were subjected to habitats with altered runoff, sediment and nutrient regimes. Here we present time-series (2000-2009) of Mn/Ca, Y/Ca and Ba/Ca variability in massive Porites corals from Nias to assess the environmental impact of a wide range of vertical displacement (+ 2...
April 15, 2024: Scientific Reports
#36
JOURNAL ARTICLE
J Michael Stolley, Milcah C Scott, Stephen D O'Flanagan, Marco Künzli, Courtney A Matson, Eyob Weyu, Ryan A Langlois, Vaiva Vezys, David Masopust
Humans experience frequent respiratory infections. Immunology and vaccinology studies in mice are typically performed in naive specific pathogen-free animals responding to their very first respiratory challenge. We found that the first respiratory infection induces lifelong enlargement of the lung-draining mediastinal lymph nodes (medLNs). Furthermore, infection-experienced medLNs supported better naive T cell surveillance and effector responses to new unrelated infections that exhibited more biased accumulation and memory establishment within the lung...
April 15, 2024: Journal of Immunology
#37
Junpeng Zhan, Sébastien Bélanger, Scott Lewis, Chong Teng, Madison McGregor, Aleksandra Beric, Michael A Schon, Michael D Nodine, Blake C Meyers
UNLABELLED: Reproductive phasiRNAs are broadly present in angiosperms and play crucial roles in sustaining male fertility. While the premeiotic 21-nt phasiRNAs and meiotic 24-nt phasiRNA pathways have been extensively studied in maize ( Zea mays ) and rice ( Oryza sativa ), a third putative category of reproductive phasiRNAs-named premeiotic 24-nt phasiRNAs-have recently been reported in barley ( Hordeum vulgare ) and wheat ( Triticum aestivum ). To determine whether premeiotic 24-nt phasiRNAs are also present in maize and related species and begin to characterize their biogenesis and function, we performed a comparative transcriptome and degradome analysis of premeiotic and meiotic anthers from five maize inbred lines and three teosinte species/subspecies...
April 1, 2024: bioRxiv
#38
JOURNAL ARTICLE
Onn Shaun Thein, Kylie Belchamber, Jon Hazeldine, Aduragbemi Faniyi, Frances Grudzinska, Michael Hughes, Alice Jasper, Kay Por Yip, Louise Crowley, Sebastian Lugg, Elizabeth Sapey, Dhruv Parekh, David Thickett, Aaron Scott
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#39
JOURNAL ARTICLE
Elisabeth Hempel, J Tyler Faith, Michaela Preick, Deon de Jager, Scott Barish, Stefanie Hartmann, José H Grau, Yoshan Moodley, Gregory Gedman, Kathleen Morrill Pirovich, Faysal Bibi, Daniela C Kalthoff, Sven Bocklandt, Ben Lamm, Love Dalén, Michael V Westbury, Michael Hofreiter
Low genomic diversity is generally indicative of small population size and is considered detrimental by decreasing long-term adaptability.1 , 2 , 3 , 4 , 5 , 6 Moreover, small population size may promote gene flow with congeners and outbreeding depression.7 , 8 , 9 , 10 , 11 , 12 , 13 Here, we examine the connection between habitat availability, effective population size (Ne ), and extinction by generating a 40× nuclear genome from the extinct blue antelope (Hippotragus leucophaeus). Historically endemic to the relatively small Cape Floristic Region in southernmost Africa,14 , 15 populations were thought to have expanded and contracted across glacial-interglacial cycles, tracking suitable habitat...
April 9, 2024: Current Biology: CB
#40
JOURNAL ARTICLE
Benjamin M Williams, Nathan D Steed, Joel T Woolley, Aubrey A Moedl, Christina A Nelson, Gavin C Jones, Matthew D Burris, Hugo R Arias, Oc-Hee Kim, Eun Young Jang, Arik J Hone, J Michael McIntosh, Jordan T Yorgason, Scott C Steffensen
Iboga alkaloids, also known as coronaridine congeners, have shown promise in the treatment of alcohol and opioid use disorders. The objective of this study was to evaluate the effects of catharanthine and 18-methoxycoronaridine (18-MC) on dopamine (DA) transmission and cholinergic interneurons in the mesolimbic DA system, nicotine-induced locomotor activity, and nicotine-taking behavior. Utilizing ex vivo fast-scan cyclic voltammetry (FSCV) in the nucleus accumbens core of male mice, we found that catharanthine or 18-MC differentially inhibited evoked DA release...
April 13, 2024: ACS Chemical Neuroscience
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