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Michael scott

Souheil-Antoine Younes, Aarthi Talla, Susan Pereira Ribeiro, Evgeniya V Saidakova, Larisa B Korolevskaya, Konstantin V Shmagel, Carey L Shive, Michael L Freeman, Soumya Panigrahi, Sophia Zweig, Robert Balderas, Leonid Margolis, Daniel C Douek, Donald D Anthony, Pushpa Pandiyan, Mark Cameron, Scott F Sieg, Leonard H Calabrese, Benigno Rodriguez, Michael M Lederman
Immune nonresponder (INR) HIV-1-infected subjects are characterized by their inability to reconstitute the CD4+ T cell pool after antiretroviral therapy. This is linked to poor clinical outcome. Mechanisms underlying immune reconstitution failure are poorly understood, although, counterintuitively, INRs often have increased frequencies of circulating CD4+ T cells in the cell cycle. While cycling CD4+ T cells from healthy controls and HIV+ patients with restored CD4+ T cell numbers complete cell division in vitro, cycling CD4+ T cells from INRs do not...
October 15, 2018: Journal of Clinical Investigation
Elizabeth Lippner, Scott H Sicherer, Michael H Land, Michael Schatz, Chitra Dinakar
No abstract text is available yet for this article.
October 11, 2018: Journal of Allergy and Clinical Immunology in Practice
Scott C Morgan, Karen Hoffman, D Andrew Loblaw, Mark K Buyyounouski, Caroline Patton, Daniel Barocas, Soren Bentzen, Michael Chang, Jason Efstathiou, Patrick Greany, Per Halvorsen, Bridget F Koontz, Colleen Lawton, C Marc Leyrer, Daniel Lin, Michael Ray, Howard Sandler
PURPOSE: The aim of this guideline is to present recommendations regarding moderately hypofractionated (240-340 cGy per fraction) and ultrahypofractionated (500 cGy or more per fraction) radiation therapy for localized prostate cancer. METHODS AND MATERIALS: The American Society for Radiation Oncology convened a task force to address 8 key questions on appropriate indications and dose-fractionation for moderately and ultrahypofractionated radiation therapy, as well as technical issues, including normal tissue dose constraints, treatment volumes, and use of image guided and intensity modulated radiation therapy...
October 9, 2018: Journal of Urology
Michael-Paul Schallmo, Rachel Millin, Alex M Kale, Tamar Kolodny, Richard A E Edden, Raphael A Bernier, Scott O Murray
There is large individual variability in human neural responses and perceptual abilities. The factors that give rise to these individual differences, however, remain largely unknown. To examine these factors, we measured fMRI responses to moving gratings in the motion-selective region MT, and perceptual duration thresholds for motion direction discrimination. Further, we acquired MR spectroscopy data, which allowed us to quantify an index of neurotransmitter levels in the region of area MT. These three measurements were conducted in separate experimental sessions within the same group of male and female subjects...
October 9, 2018: NeuroImage
Brian P Cole, Michael Baglieri, Scott Ploharz, Margaret Brennan, Michael Ternes, Tristan Patterson, Ashley Kuznia
This study explored relations between conformity to masculine norms, gender role conflict, hope, and psychological well-being among a sample of 389 men from a university, with a predominantly White student body, located in the Midwestern United States. Bivariate correlations revealed that men's conformity to masculine norms and gender role conflict were positively correlated. Bivariate correlations revealed no significant relations between conformity to masculine norms, trait hope, and psychological well-being...
October 12, 2018: American Journal of Men's Health
Gary Eitzen, Cameron C Smithers, Allan Murray, Michael Overduin
FYVE domains are highly conserved protein modules that typically bind phosphatidylinositol 3-phosphate (PI3P) on the surface of early endosomes. Along with pleckstrin homology (PH) and phox homology (PX) domains, FYVE domains are the principal readers of the phosphoinositide (PI) code that mediate specific recognition of eukaryotic organelles. Of all the human FYVE domain-containing proteins, those within the Faciogenital dysplasia (Fgd) subfamily are particularly divergent, and couple with GTPases to exert unique cellular functions...
October 11, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
Scott C Morgan, Karen Hoffman, D Andrew Loblaw, Mark K Buyyounouski, Caroline Patton, Daniel Barocas, Soren Bentzen, Michael Chang, Jason Efstathiou, Patrick Greany, Per Halvorsen, Bridget F Koontz, Colleen Lawton, C Marc Leyrer, Daniel Lin, Michael Ray, Howard Sandler
No abstract text is available yet for this article.
October 11, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Matthew Addicoat, Claire S Adjiman, Mihails Arhangelskis, Gregory J O Beran, Jan Gerit Brandenburg, Doris E Braun, Virginia Burger, Asbjoern Burow, Christopher Collins, Andrew Cooper, Graeme M Day, Volker L Deringer, Matthew S Dyer, Alan Hare, Kim E Jelfs, Julian Keupp, Stefanos Konstantinopoulos, Yi Li, Yanming Ma, Noa Marom, David McKay, Caroline Mellot-Draznieks, Sharmarke Mohamed, Marcus Neumann, Sten Nilsson Lill, Jonas Nyman, Artem R Oganov, Sarah L Price, Susan Reutzel-Edens, Michael Ruggiero, German Sastre, Rochus Schmid, Julia Schmidt, J Christian Schön, Peter Spackman, Seiji Tsuzuki, Scott M Woodley, Shiyue Yang, Qiang Zhu
No abstract text is available yet for this article.
October 11, 2018: Faraday Discussions
Kate Hosford, Daniel Fuller, Scott A Lear, Kay Teschke, Lise Gauvin, Michael Brauer, Meghan Winters
Public bicycle share programs have been implemented in cities around the world to encourage bicycling. However, there are limited evaluations of the impact of these programs on bicycling at the population level. This study examined the impact of a public bicycle share program on bicycling amongst residents of Vancouver, BC. Using an online panel, we surveyed a population-based sample of Vancouver residents three times: prior to the implementation of the public bicycle share program (T0, October 2015, n  = 1111); in the early phase of implementation (T1, October 2016, n  = 995); and one-year post implementation (T2, October 2017, n  = 966)...
December 2018: Preventive Medicine Reports
Sally Bromley, Michael Drew, Scott Talpey, Andrew McIntosh, Caroline Finch
BACKGROUND: Electronic methods are increasingly being used to manage health-related data among sporting populations. Collection of such data permits the analysis of injury and illness trends, improves early detection of injuries and illnesses, collectively referred to as health problems, and provides evidence to inform prevention strategies. The Athlete Management System (AMS) has been employed across a range of sports to monitor health. Australian combat athletes train across the country without dedicated national medical or sports science teams to monitor and advocate for their health...
October 9, 2018: JMIR Human Factors
Daniel H Johnson, Chrystia M Zobniw, Van A Trinh, Junsheng Ma, Roland L Bassett, Noha Abdel-Wahab, Jaime Anderson, Jennifer E Davis, Jocelyn Joseph, Marc Uemura, Ali Noman, Hamzah Abu-Sbeih, Cassian Yee, Rodabe Amaria, Sapna Patel, Hussein Tawbi, Isabella C Glitza, Michael A Davies, Michael K Wong, Scott Woodman, Wen-Jen Hwu, Patrick Hwu, Yinghong Wang, Adi Diab
BACKGROUND: Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX...
October 11, 2018: Journal for Immunotherapy of Cancer
Jan Cukor, František Havránek, Rostislav Linda, Karel Bukovjan, Michael Scott Painter, Vlastimil Hart
In Europe, brown hare (Lepus europaeus) populations have been declining steadily since the 1970s. Gamekeepers can help to support brown hare wild populations by releasing cage-reared hares into the wild. Survival rates of cage-reared hares has been investigated in previous studies, however, survival times in relation to seasonality, which likely plays a crucial role for the efficacy of this management strategy, has not been evaluated. Here we examine the survival duration and daytime home ranges of 22 hares released and radio-tracked during different periods of the year in East Bohemia, Czech Republic...
2018: PloS One
Matthew Addicoat, Claire S Adjiman, Mihails Arhangelskis, Gregory J O Beran, David Bowskill, Jan Gerit Brandenburg, Doris E Braun, Virginia Burger, Jason Cole, Aurora J Cruz-Cabeza, Graeme M Day, Volker L Deringer, Rui Guo, Alan Hare, Julian Helfferich, Johannes Hoja, Luca Iuzzolino, Samuel Jobbins, Noa Marom, David McKay, John B O Mitchell, Sharmarke Mohamed, Marcus Neumann, Sten Nilsson Lill, Jonas Nyman, Artem R Oganov, Pablo Piaggi, Sarah L Price, Susan Reutzel-Edens, Ivo Rietveld, Michael Ruggiero, Matthew R Ryder, German Sastre, J Christian Schön, Christopher Taylor, Alexandre Tkatchenko, Seiji Tsuzuki, Joost van den Ende, Scott M Woodley, Grahame Woollam, Qiang Zhu
No abstract text is available yet for this article.
October 10, 2018: Faraday Discussions
Scott A Helgeson, Alexander J Heckman, Josiah D McCain, Jennifer B Cowart, Michael J Maniaci, Jeffrey L Garland
Diffuse alveolar hemorrhage (DAH) is a rare, but potentially fatal, complication of antiphospholipid syndrome, and may present with acute and fulminant symptoms. We report a case of DAH presenting as sudden onset dyspnea in a gentleman with known antiphospholipid syndrome. Chest computed tomography angiography with pulmonary embolism protocol showed right lower lobe segmental filling defects, upper-lobe predominant diffuse ground-glass opacities, and centrilobular nodules bilaterally. The presence of DAH can be confirmed by bronchoalveolar lavage with serial aliquots, but this procedure typically does not elucidate the specific etiology for the hemorrhage...
October 2018: Oxford Medical Case Reports
Andrew J Toner, Scott G Douglas, Martin A Bailey, Hans J Avis, Arani V Pillai, Michael Phillips, Andrew Heard
BACKGROUND: Apneic oxygenation via the oral route using a buccal device extends the safe apnea time in most but not all obese patients. Apneic oxygenation techniques are most effective when tracheal oxygen concentrations are maintained >90%. It remains unclear whether buccal oxygen administration consistently achieves this goal and whether significant risks of hypercarbia or barotrauma exist. METHODS: We conducted a randomized trial of buccal or sham oxygenation in healthy, nonobese patients (n = 20), using prolonged laryngoscopy to maintain apnea with a patent airway until arterial oxygen saturation (SpO2) dropped <95% or 750 seconds elapsed...
October 8, 2018: Anesthesia and Analgesia
Michael A Wood, Dorothy I Shulman, Gregory P Forlenza, Bruce W Bode, Orit Pinhas-Hamiel, Bruce A Buckingham, Kevin B Kaiserman, David R Liljenquist, Timothy S Bailey, John Shin, Suiying Huang, Xiaoxiao Chen, Toni L Cordero, Scott W Lee, Francine R Kaufman
BACKGROUND: The Medtronic predictive low-glucose management (PLGM) algorithm automatically stops insulin delivery when sensor glucose (SG) is predicted to reach or fall below a preset low-glucose value within the next 30 min, and resumes delivery after hypoglycemia recovery. The present study evaluated the PLGM algorithm performance of the MiniMed™ 670G system SmartGuard™ "suspend before low" feature in children aged 7-13 years with type 1 diabetes (T1D). METHOD: Participants (N = 105, mean ± standard deviation of 10...
October 6, 2018: Diabetes Technology & Therapeutics
Brady John Bielewicz, Elisabeth George, Scott Gunn, Meredith Oroukin, Dianxu Ren, Michael Beach, Patricia Tuite
PURPOSE/OBJECTIVES: The purpose of this clinical nurse specialist-led initiative was to redefine the standard of care to reduce the deficit that exists between the daily amount of tube feedings prescribed versus received by patients in a surgical-trauma intensive care unit. DESCRIPTION OF THE PROJECT: Nutrition plays a vital role in health and wellness. Although nutritional recommendations are not always met by individuals on a daily basis-the presence of in-hospital malnutrition presents greater risks and complications after a surgery or traumatic event...
November 2018: Clinical Nurse Specialist CNS
Laura L Allen, Katie L Morrison, Wesley A E Scott, Steve Shinn, Alan M Haltiner, Michael J Doherty
BACKGROUND: Skateboarders, snowboarders, and surfers all show stance preferences for which foot is forward while moving. We are unaware of other animals than humans with a stance preference, perhaps excepting Osprey, who fly their caught fish beneath them in a foot-forward stance. We hypothesize there should be no difference between left foot forward, right foot back (conventional) versus right foot forward left foot back (goofy) stances or for fish holding with unilateral left or right foot...
October 9, 2018: Brain and Behavior
Diptavo Dutta, Laura Scott, Michael Boehnke, Seunggeun Lee
In genetic association analysis, a joint test of multiple distinct phenotypes can increase power to identify sets of trait-associated variants within genes or regions of interest. Existing multiphenotype tests for rare variants make specific assumptions about the patterns of association with underlying causal variants, and the violation of these assumptions can reduce power to detect association. Here, we develop a general framework for testing pleiotropic effects of rare variants on multiple continuous phenotypes using multivariate kernel regression (Multi-SKAT)...
October 8, 2018: Genetic Epidemiology
Camilo Jaimes, Jorge Delgado, Mary Beth Cunnane, Holly L Hedrick, N Scott Adzick, Michael S Gee, Teresa Victoria
BACKGROUND: Fetal MRI at 3 T is associated with increased acoustic noise relative to 1.5 T. OBJECTIVE: The goal of this study is to determine if there is an increased prevalence of congenital hearing loss in neonates who had a 3-T prenatal MR vs. those who had it at 1.5 T. MATERIALS AND METHODS: We retrospectively identified all subjects who had 3-T fetal MRI between 2012 and 2016 and also underwent universal neonatal hearing screening within 60 days of birth...
October 8, 2018: Pediatric Radiology
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