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Adam Bryant Miller, Mitchell J Prinstein, Emily Munier, Laura S Machlin, Margaret A Sheridan
Failures in emotion regulation, especially as a result of interpersonal stress, are implicated as transdiagnostic risk factors for psychopathology. This study examines the effects of an experimentally timed targeted interpersonal rejection on emotion reactivity and regulation in typically developing adolescent girls. Girls ( N = 33, ages 9-16 years, M = 12.47, SD = 2.20) underwent fMRI involving a widely used emotion regulation task. The emotion task involves looking at negative stimuli and using cognitive reappraisal strategies to decrease reactions to negative stimuli...
October 15, 2018: Journal of Cognitive Neuroscience
Daniel J Miller, David P Trofa, Robert L Parisien, Peter C Noback, T Sean Lynch, Charles A Popkin, Charles M Jobin, William N Levine, Christopher S Ahmad
INTRODUCTION: No Accreditation Council for Graduate Medical Education guidelines exist regarding athletic event coverage by orthopaedic residents. This study assesses the availability and characteristics of event coverage opportunities in residency programs. METHODS: An anonymous web-based survey assessing resident athletic event coverage opportunities was distributed to members (n = 158) of the American Orthopaedic Association's Council of Orthopaedic Residency Directors...
October 12, 2018: Journal of the American Academy of Orthopaedic Surgeons
Elizabeth W Murphy, Marian L Smith, Ji X He, William Wellenkamp, Edward Barr, Philip C Downey, Kenneth M Miller, Kathryn A Meyer
Incorporation of fish age into the assessment of status and trends for persistent, bioaccumulative and toxic chemicals in the Great Lakes has become an important step for the U.S. EPA's Great Lakes Fish Monitoring and Surveillance Program (GLFMSP). A slowing in the rate of decline for total PCBs in Lake Huron beginning in 2000, led the Program to complete a retrospective analysis to assess how chemical contamination may be influenced by fish age. Analytical results suggest that fish age is an important variable when assessing contaminant trends and that the Program needed to revise its compositing scheme to group fish according to age, rather than by length, prior to homogenization and chemical analysis...
August 2018: Journal of Great Lakes Research
Jennifer L Kaczmarek, Xiaoji Liu, Craig S Charron, Janet A Novotny, Elizabeth H Jeffery, Harold E Seifried, Sharon A Ross, Michael J Miller, Kelly S Swanson, Hannah D Holscher
The human gastrointestinal microbiota is increasingly linked to health outcomes; however, our understanding of how specific foods alter the microbiota is limited. Cruciferous vegetables such as broccoli are a good source of dietary fiber and phytonutrients, including glucosinolates, which can be metabolized by gastrointestinal microbes. This study aimed to determine the impact of broccoli consumption on the gastrointestinal microbiota of healthy adults. A controlled feeding, randomized, crossover study consisting of two 18-day treatment periods separated by a 24-day washout was conducted in healthy adults (n=18)...
September 21, 2018: Journal of Nutritional Biochemistry
K Rivet Amico, Jessica Miller, Christopher Balthazar, Pedro Alonso Serrano, Jennifer Brothers, Sarah Zollweg, Sybil Hosek
Pre-exposure prophylaxis (PrEP) for the prevention of HIV infection among young men who have sex with men is a critical part of the HIV prevention landscape in the US. Given the unique challenges and resources of young MSM negotiating safer sex practices, including PrEP, counseling and supportive discussions to optimize both PrEP use and sexual health protection more generally may facilitate reaching HIV prevention goals. Within the context of a large, open-label PrEP study (ATN110/113), support for sexual health promotion and PrEP use was provided through use of integrated Next Step Counseling (iNSC) as part of study visits...
October 9, 2018: AIDS and Behavior
Kathryn E Miller, Ryan D Coleman, Leah Eisenberg, Joan Henriksen, John D Lantos, Elliott Mark Weiss
An infant with complex congenital heart disease suffers a prolonged cardiac arrest with minutes of anoxia. He is left with severe brain damage and profound neurologic impairment. He no longer responds to caregivers. Much of the time, he cries and grimaces as if in pain. He has required increasing sedation to control these symptoms. His parents live hours from the hospital and seldom visit. When their infant's situation is explained to them over the telephone, they request that doctors "do everything to keep him alive...
October 12, 2018: Pediatrics
Sarah Croessmann, Luigi Formisano, Lisa Kinch, Paula I Gonzalez-Ericsson, Dhivya R Sudhan, Rebecca J Nagy, Aju Mathew, Eric H Bernicker, Massimo Cristofanilli, Jie He, Richard E Cutler, Alshad S Lalani, Vincent A Miller, Richard B Lanman, Nick Grishin, Carlos L Arteaga
PURPOSE: We examined the role of ERBB2 activating mutations in endocrine therapy resistance in estrogen receptor positive (ER+) breast cancer. Design ERBB2 mutation frequency was determined from large genomic databases. Isogenic knock-in ERBB2 mutations in ER+ MCF7 cells and xenografts were used to investigate estrogen-independent growth. Structural analysis was used to determine the molecular interaction of HER L755S with HER3. Small molecules and siRNAs were used to inhibit PI3Kα, TORC1 and HER3...
October 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
K K Davison, C E Blake, A Kachurak, J C Lumeng, D L Coffman, A L Miller, S O Hughes, T G Power, A F Vaughn, R E Blaine, N Younginer, J O Fisher
No abstract text is available yet for this article.
October 9, 2018: Appetite
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal Kantarci, Virginia M Miller
OBJECTIVES: We investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population. STUDY DESIGN: In an established cohort study, we used the records-linkage system of the Rochester Epidemiology Project (REP to identify 1653 premenopausal women who underwent bilateral oophorectomy in Olmsted County, Minnesota between 1988 and 2007 for a nonmalignant indication...
November 2018: Maturitas
Bing Li, Zhe Zhao, Chuntian Zhang, Shuqiang Li
Two new genera of Coelotinae F.O.Pickard-Cambridge, 1893 from Southwest China are described: Nuconarius Z. Zhao S. Li gen. n. and Hengconarius Z. Zhao S. Li gen. n. The type species of Nuconarius Z. Zhao S. Li gen. n. is N. brevipatellatus Z. Zhao S. Li sp. n. and two additional species also belong here: N. capitulatus (Wang, 2003) comb. n. and N. pseudocapitulatus (Wang, 2003) comb. n. The type species of Hengconarius Z. Zhao S. Li gen. n. is H. exilis (Zhang, Zhu Wang, 2005) comb. n. and this genus includes seven additional species: H...
August 8, 2018: Zootaxa
Kelsey A Miller, Debra Hillier, Christiana Russ, Marcella Luercio, Ariel S Winn
No abstract text is available yet for this article.
October 9, 2018: Academic Pediatrics
Frank Qian, Shengfeng Wang, Jonathan Mitchell, Lesley McGuffog, Daniel Barrowdale, Goska Leslie, Jan C Oosterwijk, Wendy K Chung, D Gareth Evans, Christoph Engel, Karin Kast, Cora M Aalfs, Muriel A Adank, Julian Adlard, Bjarni A Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Banu K Arun, Margreet G E M Ausems, Jacopo Azzollini, Emmanuelle Barouk-Simonet, Julian Barwell, Muriel Belotti, Javier Benitez, Andreas Berger, Ake Borg, Angela R Bradbury, Joan Brunet, Saundra S Buys, Trinidad Caldes, Maria A Caligo, Ian Campbell, Sandrine M Caputo, Jocelyne Chiquette, Kathleen B M Claes, J Margriet Collée, Fergus J Couch, Isabelle Coupier, Mary B Daly, Rosemarie Davidson, Orland Diez, Susan M Domchek, Alan Donaldson, Cecilia M Dorfling, Ros Eeles, Lidia Feliubadaló, Lenka Foretova, Jeffrey Fowler, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Vanesa Garcia-Barberan, Gord Glendon, Andrew K Godwin, Encarna B Gómez Garcia, Jacek Gronwald, Eric Hahnen, Ute Hamann, Alex Henderson, Carolyn B Hendricks, John L Hopper, Peter J Hulick, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Ángel Izquierdo, Anna Jakubowska, Katarzyna Kaczmarek, Eunyoung Kang, Beth Y Karlan, Carolien M Kets, Sung-Won Kim, Zisun Kim, Ava Kwong, Yael Laitman, Christine Lasset, Min Hyuk Lee, Jong Won Lee, Jihyoun Lee, Jenny Lester, Fabienne Lesueur, Jennifer T Loud, Jan Lubinski, Noura Mebirouk, Hanne E J Meijers-Heijboer, Alfons Meindl, Austin Miller, Marco Montagna, Thea M Mooij, Patrick J Morrison, Emmanuelle Mouret-Fourme, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn C Nielsen, Robert L Nussbaum, Kenneth Offit, Edith Olah, Kai-Ren Ong, Laura Ottini, Sue K Park, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Bruce Poppe, Nisha Pradhan, Paolo Radice, Susan J Ramus, Johanna Rantala, Mark Robson, Gustavo C Rodriguez, Rita K Schmutzler, Christina G Hutten Selkirk, Payal D Shah, Jacques Simard, Christian F Singer, Johanna Sokolowska, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, R Manuel Teixeira, Soo H Teo, Mary Beth Terry, Thomassen Mads, Tischkowitz Marc, E Toland Amanda, M Tucker Katherine, Tung Nadine, Christi J van Asperen, Klaartje van Engelen, Elizabeth J van Rensburg, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N Weitzel, Drakoulis Yannoukakos, Mark H Greene, Matti A Rookus, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, David E Goldgar, Olufunmilayo I Olopade, Timothy R Rebbeck, Dezheng Huo
Background: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer...
October 12, 2018: Journal of the National Cancer Institute
Karen L Sweazea, Carol S Johnston, Brendan Miller, Eric Gumpricht
Nitric oxide (NO) is a primary vasodilatory factor released from endothelial cells of the peripheral vasculature. NO production is stimulated through enzymatic-dependent mechanisms via NO synthase and from dietary intake of nitrate-containing foods or supplements. We evaluated the efficacy of a nitrate-rich fruit and vegetable liquid supplement (FVS, AMPED NOx, Isagenix International LLC) versus a juice low in nitrates (prune juice, PRU) on circulating nitrates/nitrites as well as cardiovascular parameters in 45 healthy normotensive men (18-40 y)...
2018: Journal of Nutrition and Metabolism
Kharine R Jean, Cutter A Lindbergh, Catherine M Mewborn, Talia L Robinson, Marissa A Gogniat, L S Miller
Objectives: Given that black American older adults are more likely to have lower educational attainment and perform worse on cognitive tests than white Americans, we examined whether increased education would confer greater cognitive advantage to black Americans on measures of global and specific domains of cognitive function. Methods: The sample included 522 community-dwelling older adults from a larger study. An analysis of covariance was conducted with race and education as between-participant factors and global cognition as the dependent variable...
October 10, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Nathan K LeBrasseur, Marissa J Schafer, Michelle M Mielke, Kejal Kantarci, Elizabeth A Stewart, Virginia M Miller
Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.
November 1, 2018: Physiology
Oleg Palygin, Bradley S Miller, Yoshinori Nishijima, David X Zhang, Alexander Staruschenko, Andrey Sorokin
Adaptor protein p66Shc is overexpressed in smooth muscle cells of renal resistance vessels of hypertensive salt-sensitive rats and is involved in the regulation of renal vascular tone. We applied 2-photon laser scanning fluorescence microscopy to analyze spontaneous dynamic fluctuations in intracellular calcium concentrations ([Ca2+ ]i ) in smooth muscle cells embedded in the walls of freshly isolated renal resistance arteries. The amplitude, number of events, and frequency of spontaneous [Ca2+ ]i oscillations triggered by endogenously released endothelin-1 were recorded in smooth muscle cells of the renal arteries...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
M L Weber, R C Lynall, N L Hoffman, E H Miller, T W Kaminski, T A Buckley, H J Benjamin, C M Miles, C T Whitlow, L Lintner, S P Broglio, M McCrea, T McAllister, J D Schmidt
The purpose of this study was to compare global and specific health-related quality of life (HRQOL) throughout concussion recovery between those with and without concussion history. Student-athletes diagnosed with concussion completed global (Short Form-12v2; SF-12) and specific (Hospital Anxiety and Depression Scale: HADS) HRQOL assessments at baseline, 24-48 h, asymptomatic, return-to-play, and 6-months post-injury. Baseline scores were compared to post-injury time points for SF-12 subscores (physical and mental; PCS-12, MCS-12) and HADS subscores (depression and anxiety; HADS-D, HADS-A)...
October 9, 2018: Annals of Biomedical Engineering
Thammajun L Wood, Ting Gong, Lei Zhu, James Miller, Daniel S Miller, Bei Yin, Thomas K Wood
Biofilm formation is an important problem for many industries. Desulfovibrio vulgaris is the representative sulfate-reducing bacterium (SRB) which causes metal corrosion in oil wells and drilling equipment, and the corrosion is related to its biofilm formation. Biofilms are extremely difficult to remove since the cells are cemented in a polymer matrix. In an effort to eliminate SRB biofilms, we examined the ability of supernatants from Pseudomonas aeruginosa PA14 to disperse SRB biofilms. We found that the P ...
2018: NPJ Biofilms and Microbiomes
Gabe Haller, Kevin McCall, Supak Jenkitkasemwong, Brooke Sadler, Lilian Antunes, Momchil Nikolov, Julia Whittle, Zachary Upshaw, Jimann Shin, Erin Baschal, Carlos Cruchaga, Matthew Harms, Cathleen Raggio, Jose A Morcuende, Philip Giampietro, Nancy H Miller, Carol Wise, Ryan S Gray, Lila Solnica-Krezel, Mitchell Knutson, Matthew B Dobbs, Christina A Gurnett
Genetic factors predictive of severe adolescent idiopathic scoliosis (AIS) are largely unknown. To identify genetic variation associated with severe AIS, we performed an exome-wide association study of 457 severe AIS cases and 987 controls. We find a missense SNP in SLC39A8 (p.Ala391Thr, rs13107325) associated with severe AIS (P = 1.60 × 10-7 , OR = 2.01, CI = 1.54-2.62). This pleiotropic SNP was previously associated with BMI, blood pressure, cholesterol, and blood manganese level. We replicate the association in a second cohort (841 cases and 1095 controls) resulting in a combined P = 7...
October 9, 2018: Nature Communications
Justin Loloi, Amanda J Miller, Sarah S Bingaman, Yuval Silberman, Amy C Arnold
Angiotensin converting enzyme (ACE) inhibitors reduce body weight, lower blood pressure (BP), and improve insulin sensitivity in animal models of cardiometabolic syndrome. These effects are generally attributed to reduced angiotensin (Ang) II formation; however, these therapies also increase levels of Ang-(1-7), a beneficial hormone opposing Ang II actions. We hypothesized this Ang-(1-7) generation contributes to the insulin sensitizing effects of ACE inhibition in obese mice. Adult male C57BL/6J mice were placed on a 60% high fat diet for 11 weeks...
October 9, 2018: American Journal of Physiology. Endocrinology and Metabolism
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