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depression meta

Ioannis D Morres, Antonis Hatzigeorgiadis, Afroditi Stathi, Nikos Comoutos, Chantal Arpin-Cribbie, Charalampos Krommidas, Yannis Theodorakis
Although exercise is associated with depression relief, the effects of aerobic exercise (AE) interventions on clinically depressed adult patients have not been clearly supported. The purpose of this meta-analysis was to examine the antidepressant effects of AE versus nonexercise comparators exclusively for depressed adults (18-65 years) recruited through mental health services with a referral or clinical diagnosis of major depression. Eleven e-databases and bibliographies of 19 systematic reviews were searched for relevant randomized controlled clinical trials...
October 18, 2018: Depression and Anxiety
Beverly H Brummett, Michael A Babyak, Abanish Singh, Elizabeth R Hauser, Rong Jiang, Kim M Huffman, William E Kraus, Svati H Shah, Ilene C Siegler, Redford B Williams
The serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. One coding variant in the HTR2C gene, Cys23Ser (rs6318), has been associated with depressive symptoms. and adiposity; however, these findings have been inconsistent. The reasons for this mixed picture may be due to low statistical power or due to other factors such as failure to account for possible interacting environmental factors, such as psychosocial stress...
2018: Frontiers in Genetics
Lei Qiu, Qin Yang, Na Sun, Dandan Li, Yuxin Zhao, Xiaotong Li, Yanhong Gong, Chuanzhu Lv, Xiaoxv Yin
BACKGROUND: Several studies have suggested that depression is associated with an increased risk for fracture; however, the results are conflicting. This study aimed to conduct a meta-analysis of cohort studies assessing the association between depression and the risk for fracture. METHODS: Relevant studies were identified by a search of Web of Science, PubMed, Embase, China National Knowledge Infrastructure and WanFang database to Feb 2018. Cohort studies on the relationship between depression and the risk for fracture in the general population were included in the meta-analysis...
October 17, 2018: BMC Psychiatry
Andre R Brunoni, Bernardo Sampaio-Junior, Adriano H Moffa, Luana V Aparício, Pedro Gordon, Izio Klein, Rosa M Rios, Lais B Razza, Colleen Loo, Frank Padberg, Leandro Valiengo
OBJECTIVE: Noninvasive brain stimulation (NIBS) techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), are increasingly being used to treat mental disorders, particularly major depression. The aim of this comprehensive review is to summarize the main advances, limitations, and perspectives of the field. METHODS: We searched PubMed and other databases from inception to July 2017 for articles, particularly systematic reviews and meta-analyses, evaluating the use of NIBS in psychiatric disorders...
October 11, 2018: Revista Brasileira de Psiquiatria
Nanhua Zhang, Eloise E Kaizar, Megan E Narad, Brad G Kurowski, Keith Owen Yeates, H Gerry Taylor, Shari L Wade
A series of five randomized controlled clinical trials (RCTs) conducted between 2002 and 2015 support the potential efficacy of online family problem-solving treatment (OFPST) in improving both child and parent/family outcomes after pediatric traumatic brain injury (TBI). However, small sample sizes and heterogeneity across individual studies have precluded examination of potentially important moderators. We jointly analyzed individual participant data (IPD) from these five RCTs, involving 359 children between the ages of 5 and 18 years, to confirm the role of previously identified moderators (child's age and pre-treatment symptom levels, parental education) and to examine other potential moderators (race, sex, IQ), using IPD meta-analysis...
October 17, 2018: Journal of Neurotrauma
Deirdre Noone, Josh Stott, Elisa Aguirre, Kelly Llanfear, Aimee Spector
OBJECTIVES: Assess the effectiveness of psychosocial interventions for depression and anxiety in people with dementia (PWD) or mild cognitive impairment (MCI). METHOD: OvidMedline, PsychInfo and Embase were searched for studies on the 5th August 2017. The efficacy of the studies was estimated using meta-analyses. RESULTS: Eight RCTs were included. No RCTs were identified for people with MCI. Four RCTs found that psychosocial interventions (multicomponent intervention, Tai Chi, problem adaptation therapy and exercise/walking) were effective at reducing symptoms of depression in PWD who were depressed...
October 17, 2018: Aging & Mental Health
Felix Akpojene Ogbo, Sruthi Mathsyaraja, Rajeendra Kashyap Koti, Janette Perz, Andrew Page
BACKGROUND: Globally, depressive disorders are one of the most common forms of mental illness. Using data from the most recent Global Burden of Disease, Injury, and Risk Factor Study 2016 (GBD 2016), we aimed to describe the burden of disease attributable to depressive disorders in terms of prevalence and disability-adjusted life years (DALYs) in South Asia countries (namely India, Pakistan, Bangladesh, Nepal and Bhutan). METHODS: GBD 2016 used epidemiological data on depressive disorders (major depression and dysthymia) from South Asia and a Bayesian meta-regression tool (DisMod-MR 2...
October 16, 2018: BMC Psychiatry
Lisa S Rotenstein, Matthew Torre, Marco A Ramos, Rachael C Rosales, Constance Guille, Srijan Sen, Douglas A Mata
Importance: Burnout is a self-reported job-related syndrome increasingly recognized as a critical factor affecting physicians and their patients. An accurate estimate of burnout prevalence among physicians would have important health policy implications, but the overall prevalence is unknown. Objective: To characterize the methods used to assess burnout and provide an estimate of the prevalence of physician burnout. Data Sources and Study Selection: Systematic search of EMBASE, ERIC, MEDLINE/PubMed, psycARTICLES, and psycINFO for studies on the prevalence of burnout in practicing physicians (ie, excluding physicians in training) published before June 1, 2018...
September 18, 2018: JAMA: the Journal of the American Medical Association
Lili Huang, Yunzhi Zhao, Chunfang Qiang, Bozhen Fan
The present study evaluated the combined effectiveness of cognitive behavioral therapy (CBT) for postnatal depression. A systematic search was conducted across databases including PubMed, Embase, and the Cochrane library to identify the randomized controlled trials (RCTs) that assessing CBT versus control for postnatal depression until March 2017. Data was extracted by two reviewers, independently. The Review Manager 5.3 and Stata 11.0 were used to calculate the synthesized effect of CBT on depression, and anxiety...
2018: PloS One
Yan Yang, Kathryn Fletcher, Richard Whitehead, Greg Murray
There is growing interest in psychological processes that might be targeted in treatments for bipolar disorder (BD). One such process is a vulnerability at the level of self-concept, characterized by presence of, and fluctuations between positive and negative self-concept. The aim of the present study was to advance this literature by investigating the role of two emerging meta-cognitive processes - self-compassion and nonattachment to self - which have potential to therapeutically modulate this unstable self-concept in BD...
2018: Frontiers in Psychology
Jian Wang, Yao Zhou, Kang Chen, Yuntian Jing, Jiaan He, Hongxiao Sun, Xinhua Hu
OBJECTIVE: The purpose of the present meta-analysis was to evaluate the association between the inflammatory potential of diet, determined by the dietary inflammatory index (DII®) score, and depression. DESIGN: Systematic review and meta-analysis. SETTING: A comprehensive literature search was conducted in PubMed, Web of Science and EMBASE databases up to August 2018. All observational studies that examined the association of the DII score with depression/depressive symptoms were included...
October 15, 2018: Public Health Nutrition
Shi Tang, Lu Lu, Lianqing Zhang, Xinyu Hu, Xuan Bu, Hailong Li, Xiaoxiao Hu, Yingxue Gao, Zirui Zeng, Qiyong Gong, Xiaoqi Huang
BACKGROUND: Although dysfunction of amygdala-related circuits is centrally implicated in major depressive disorder (MDD), little is known about how this dysfunction differs between adult and adolescent MDD patients. METHODS: Voxel-wise meta-analyses of abnormal amygdala resting-state functional connectivity (rsFC) were conducted in adult and adolescent groups separately, followed by a quantitative meta-analytic comparison of the two groups. FINDINGS: Nineteen studies that included 665 MDD patients (392 adults and 273 adolescents) and 546 controls (341 adults and 205 adolescents) were identified in the current study...
October 10, 2018: EBioMedicine
Laura G Cooney, Anuja Dokras
Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with symptoms of oligomenorrhea or hirsutism or when presenting for infertility care. The health risks associated out of PCOS, however, go far beyond management of these common presenting symptoms or fertility treatment and likely extend past the reproductive years through and beyond menopause. International surveys suggest that most patients are dissatisfied with long-term counseling related to medical and psychologic issues...
October 2018: Fertility and Sterility
Sydney E Liang, Jeffrey M Cohen, Roger S Ho
Psoriasis is a chronic systemic inflammatory skin disease, which has been associated with an increased risk of numerous medical and psychiatric comorbidities, including suicidality. Suicidality, which can be divided into the categories of suicidal ideation, suicide attempt, and completed suicide, is highly prevalent in the psoriasis population, and multiple studies have been published on the subject of psoriasis and suicidal ideation and behavior (SIB), including two recent meta-analyses. However, the available literature is limited and inconsistent, and the association between the two remains incompletely understood...
October 12, 2018: Dermatologic Therapy
Sho Moriguchi, Akihiro Takamiya, Yoshihiro Noda, Nobuyuki Horita, Masataka Wada, Sakiko Tsugawa, Eric Plitman, Yasunori Sano, Ryosuke Tarumi, Muhammad ElSalhy, Nariko Katayama, Kamiyu Ogyu, Takahiro Miyazaki, Taishiro Kishimoto, Ariel Graff-Guerrero, Jeffrey H Meyer, Daniel M Blumberger, Zafiris J Daskalakis, Masaru Mimura, Shinichiro Nakajima
Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of depression, and the glutamatergic system represents a treatment target for depression. To summarize the nature of glutamatergic alterations in patients with depression, we conducted a meta-analysis of proton magnetic resonance (1 H-MRS) spectroscopy studies examining levels of glutamate. We used the search terms: depress* AND (MRS OR "magnetic resonance spectroscopy"). The search was performed with MEDLINE, Embase, and PsycINFO...
October 12, 2018: Molecular Psychiatry
Philip Murphy, Richard P Bentall, Daniel Freeman, Suzanne O'Rourke, Paul Hutton
BACKGROUND: An influential psychological model of persecutory delusions proposed that they are caused by a bias towards holding others responsible for negative events (an externalising attributional bias), preventing the individual from becoming aware of underlying low self-esteem. An early version of the model predicted self-esteem would, therefore, be preserved in people with these delusions, but a later version suggested it would be unstable, and that there would be a discrepancy between explicit and implicit self-esteem, with the latter being lower...
October 9, 2018: Lancet Psychiatry
Mei-Zhen Yuan, Qin Fang, Guang-Wei Liu, Min Zhou, Jian-Mei Wu, Chun-Yun Pu
BACKGROUND: The incidence of depression is very common among patients with post-acute coronary syndrome (ACS) and leads to adverse outcomes. AIMS: The aim of this meta-analysis was to detect risk factors for depression among patients with ACS and to provide clinical evidence for its prevention. METHODS: The authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline to search the PubMed, Web of Science, EMBASE, and EBSCO databases from January 1996 to March 2018...
October 11, 2018: Journal of Cardiovascular Nursing
Thomas Drago, Patrick W O'Regan, Ivan Welaratne, Shane Rooney, Aoife O'Callaghan, Marissa Malkit, Elena Roman, Kirk J Levins, Lauren Alexander, Denis Barry, Erik O'Hanlon, Veronica O'Keane, Darren William Roddy
BACKGROUND: Magnetic resonance spectroscopy (MRS) is a non-invasive analytical technique that investigates the presence and concentrations of brain metabolites. In the context of major depressive disorder (MDD), MRS has revealed regional biochemical changes in GABA, glutamate, and choline across different brain compartments. Technical and methodological advances in MRS data acquisition, in particular proton-based 1 H-MRS, have resulted in a significant increase in the incidence of reports utilizing the technique for psychiatric disorder research and diagnosis...
October 12, 2018: Systematic Reviews
Diego José Brandão, Leonardo Ferreira Fontenelle, Simone Almeida da Silva, Paulo Rossi Menezes, Maria Asunción Pastor-Valero
OBJECTIVE: To investigate the association between depression and mortality in the elderly living in low- and middle-income countries. METHODS: A systematic review and meta-analysis was performed. We searched in five electronic databases for observational studies investigating the association between mortality and depression. Two reviewers worked independently to select articles, extract data and assess study quality. RESULTS: A total of 10 studies including 13,828 participants (2,402 depressed and 11,426 non-depressed) from 6 countries (Brazil, 4 articles; China, 2 articles; Botswana, India, South Africa and South Korea, 1 article) were included...
October 10, 2018: International Journal of Geriatric Psychiatry
Susanne Rösner, Christian Englbrecht, Renate Wehrle, Göran Hajak, Michael Soyka
BACKGROUND: Insomnia is a major public health issue affecting between 6% to 10% of the adult population in Western countries. Eszopiclone is a hypnotic drug belonging to a newer group of hypnotic agents, known as new generation hypnotics, which was marketed as being just as effective as benzodiazepines for this condition, while being safer and having a lower risk for abuse and dependence. It is the aim of the review to integrate evidence from randomised controlled trials and to draw conclusions on eszopiclone's efficacy and safety profile, while taking methodological features and bias risks into consideration...
October 10, 2018: Cochrane Database of Systematic Reviews
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