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acute heart failure, mortality

Takafumi Nakayama, Atsushi Okada, Takuya Hasegawa, Yoshiaki Morita, Hideaki Kanzaki, Kizuku Yamashita, Yusuke Shimahara, Tomoyuki Fujita, Satoshi Yasuda, Junjiro Kobayashi
OBJECTIVE: The standard treatment of prosthetic paravalvular leakage (PVL) accompanied by heart failure or hemolytic anemia is repeat open surgery. Although favorable outcomes for transcatheter prosthetic PVL closure in patients with a high surgical risk for repeat open surgery have been reported, procedural feasibility has not been examined in Japan. METHODS: From March 2015 to November 2015, transcatheter PVL closure in mitral position was performed in four patients (age range 41-78, three females) with high surgical risk due to history of repeated surgeries, chest radiation and reconstruction of the mitral annulus after debridement of abscess owing to infective endocarditis...
December 14, 2018: General Thoracic and Cardiovascular Surgery
Chiara Ventre, Sian Nowell, Catriona Graham, Doug Kidd, Christos Skouras, Damian J Mole
INTRODUCTION: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival. OBJECTIVE: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP. DESIGN: Cohort study. SETTING: Electronic healthcare registries in Scotland. PARTICIPANTS: The ccAP cohort included 1471 patients admitted to critical care with AP between 1 January 2008 and 31 December 2010 followed up until 31 December 2014...
December 14, 2018: BMJ Open
Jae Yeong Cho, Kye Hun Kim, Hyun-Jai Cho, Hae-Young Lee, Jin-Oh Choi, Eun-Seok Jeon, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Youngkeun Ahn, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
BACKGROUND: We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). METHODS: Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69...
2018: PloS One
Giuseppe Regolisti, Luigi Gerra, Francesca Di Mario, Marco Delsante, Giovani Piotti, Chiara Cantarelli, Giovani Piotti, Santo Morabito, Marco Brambilla, Vincenzo Cantaluppi, Umberto Maggiore, Enrico Fiaccadori
Acute Kidney Injury (AKI) is an important issue for the healthcare system, as it is associated with high mortality and increased risk of readmission, with consequent elevated healthcare resource utilization. We investigated the incidence of AKI based on the examination of the discharge cards of all patients admitted between January 1 2011 and December 31 2015 at the Parma University Hospital, as well as the frequency and type of 30-day hospital readmission in the patients discharged with a first AKI diagnosis (index admission)...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Yun Yun Go, Reinhard Sellmair, John C Allen, Anders Sahlén, Heerajnarain Bulluck, David Sim, Fazlur R Jaufeerally, Michael R MacDonald, Zhan Yun Lim, Ping Chai, Seet Yoong Loh, Jonathan Yap, Carolyn S P Lam
AIMS: We aimed to identify a 'frequent admitter' phenotype among patients admitted for acute decompensated heart failure (HF). METHODS AND RESULTS: We studied 10 363 patients in a population-based prospective HF registry (2008-2012), segregated into clusters based on their 3-year HF readmission frequency trajectories. Using receiver-operating characteristic analysis, we identified the index year readmission frequency threshold that most accurately predicts HF admission frequency clusters...
December 13, 2018: European Journal of Heart Failure
Matthew R Zeglinski, Adel Rezaei Moghadam, Sudharsana R Ande, Kimia Sheikholeslami, Pooneh Mokarram, Zahra Sepehri, Haleh Rokni, Nima Khadem Mohtaram, Mansour Poorebrahim, Anahita Masoom, Mehnosh Toback, Niketa Sareen, Sekaran Saravanan, Davinder S Jassal, Mohammad Hashemi, Hassan Marzban, Dedmer Schaafsma, Pawan Singal, Jeffrey T Wigle, Michael P Czubryt, Mohsen Akbari, Ian M C Dixon, Saeid Ghavami, Joseph W Gordon, Sanjiv Dhingra
Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF...
December 13, 2018: Comprehensive Physiology
Francesc Formiga, Rafael Moreno-Gonzalez, David Chivite, Sergi Yun, Jonathan Franco, Albert Ariza-Solé, Xavier Corbella
AIM: To assess whether 1-year mortality in older patients experiencing a first admission for acute heart failure was related to sex, and to explore differential characteristics according to sex. METHODS: We reviewed the medical records of 1132 patients aged >70 years of age admitted within a 3-year period because of a first episode of acute heart failure. We analyzed sex differences. Mortality was assessed using multivariate Cox analysis. RESULTS: There were 648 (57...
December 12, 2018: Geriatrics & Gerontology International
Dehua Zhao, Jing Chen, Xiaojun Liu, Xiaoqing Long, Lisha Cao, Jisheng Wang
Paclitaxel (PTX) is an antimicrotubule agent, and is effective in treating a wide range of solid tumors. However, its use may lead to cardiovascular toxicities, the manifestations of which include arrhythmia, heart failure, acute myocardial ischemia and atrial fibrillation (AF). AF is among the severe reactions to the PTX cardiotoxicity, and a cause for substantial morbidity and mortality. However, the incidence of PTX-induced AF is reportedly low (1.0-1.7% worldwide), and few cases have been reported in the literature...
December 2018: Biomedical Reports
Sonja E van Roeden, Peter C Wever, Linda M Kampschreur, Paul Gruteke, Wim van der Hoek, Andy I M Hoepelman, Chantal P Bleeker-Rovers, Jan Jelrik Oosterheert
OBJECTIVES: Chronic infection with Coxiella burnetii (chronic Q fever) can cause life threatening conditions such as endocarditis, infected vascular prostheses and infected arterial aneurysms. We aimed to assess prognosis of chronic Q fever patients in terms of complications and mortality. METHODS: A large cohort of chronic Q fever patients was assessed to describe complications, overall mortality and chronic Q fever-related mortality. Chronic Q fever-related mortality was expressed as a case fatality rate (number of chronic Q fever-related deaths / number of chronic Q fever patients)...
December 10, 2018: Clinical Microbiology and Infection
Alpesh Amin, W Richey Neuman, Melissa Lingohr-Smith, Brandy Menges, Jay Lin
INTRODUCTION: Venous thromboembolism (VTE) is a leading cause of preventable morbidity and mortality among hospitalized patients in the US. The objectives of this study were to examine VTE prophylaxis patterns and risk for VTE events during hospitalization and post-discharge among patients hospitalized for acute illnesses in the US. METHODS: Acutely ill hospitalized patients were identified from the MarketScan databases (January 1, 2012-June 30, 2015). Proportions of patients that received inpatient and/or outpatient VTE prophylaxis were determined...
December 12, 2018: Advances in Therapy
Navin K Kapur, Shiva Annamalai, Lara Reyelt, Samuel J Karmiy, Allen A Razavi, Sina Foroutanjazi, Aditya Chennojwala, Kiyotake Ishikawa
Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970's, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. In the past decade, this hypothesis has been studied using contemporary circulatory support pumps. We will review the most recent series of preclinical studies in the field which led to the recently completed Door to Unload ST-segment Elevation Myocardial Infarction (DTU-STEMI) safety and feasibility pilot trial...
2018: F1000Research
Samson Okello, Fardous Charles Abeya, Boniface Amanee Elias Lumori, Suzan Joan Akello, Christopher Charles Moore, Brian H Annex, Andrew J Buda
BACKGROUND: The health-related quality of life (HRQoL) is an important treatment goal that could serve as low-cost prognostication tool in resource poor settings. We sought to validate the Kansas City Cardiomyopathy Questionnaire (KCCQ) and evaluate its use as a predictor of 3 months all-cause mortality among heart failure participants in rural Uganda. METHODS: The Mbarara Heart Failure Registry Cohort study observes heart failure patients during hospital stay and in the community in rural Uganda...
December 12, 2018: BMC Cardiovascular Disorders
Barna Szabó, Eszter Krisztina Marosi, Katarina Vargová, Noémi Nyolczas
AIMS: Left ventricular ejection fraction (LVEF) is the most frequently used parameter in the assessment of heart failure (HF). Cardiac index (CI) is considered a potential alternative to LVEF despite limited evidence. We aimed to assess and compare the predictive accuracy of LVEF and echocardiographically-assessed CI in HF patients. METHODS AND RESULTS: A single-centre, retrospective cohort study was conducted in patients hospitalized for acute HF from 2010-2016...
2018: PloS One
Zhu Zhaowei, Peng Xiaofan, Xie Hebin, Tian Cuihong, Xing Haoran, Liu Qinna, Liu Zhenzhen, Hu Xinqun, Fang Zhenfei, Tang Jianjun, Zhao Yanshu, Yuan Hong, Shi Chun, Tai Shi, Liu Qiming, Jiang Hejun, Lv Xiaoling, Zhou Shenghua
Patients with acute coronary syndrome (ACS) face high postevent mortality. This study aims to evaluate the impact of living without spouse on 1-year mortality of ACS patients. This retrospective study enrolled a total of 600 consecutive patients (≥75 years of age) with ACS hospitalized in our hospital between January 2013 and December 2016. Patients' clinical characteristics, laboratory values, hospital course, demographic characteristics, and angiographic data were collected. Patients were divided into 2 groups according to living with (n = 396) or without (n = 204) spouse...
January 1, 2019: American Journal of Cardiology
Supachoke Mangmool, Warisara Parichatikanond, Hitoshi Kurose
Heart failure (HF) is a heart disease that is classified into two main types: HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Both types of HF lead to significant risk of mortality and morbidity. Pharmacological treatment with β-adrenergic receptor (βAR) antagonists (also called β-blockers) has been shown to reduce the overall hospitalization and mortality rates and improve the clinical outcomes in HF patients with HFrEF but not HFpEF. Although, the survival rate of patients suffering from HF continues to drop, the management of HF still faces several limitations and discrepancies highlighting the need to develop new treatment strategies...
2018: Frontiers in Pharmacology
Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
December 7, 2018: Kidney & Blood Pressure Research
C-Q Miao, Q Lu, P Liu, L Bai, H Qu, A-Q Ma
OBJECTIVE: Nardilysin (N-arginine dibasic convertase, NRDC) is a kind of metalloendopeptidase associated with several inflammatory diseases. NRDC is reported to be eligible for early detection of acute coronary syndrome. However, the availability and effectiveness of NRDC in predicting the prognosis of patients with ST-elevation myocardial infarction has never been investigated. PATIENTS AND METHODS: From January 2010 to January 2012, the prospective observational cohort study enrolled a total of 396 STEMI patients, who were sampled with blood within 24 hours after admission...
November 2018: European Review for Medical and Pharmacological Sciences
Jinhui Wang, Weijian Zhou, Xiaoning Yin
Hyponatremia at admission is predictive of poor prognosis in patients with acute decompensated heart failure (ADHF). We performed a meta-analysis of cohort studies to evaluate whether improvement of hyponatremia is associated with improved survival in patients with ADHF and hyponatremia. Relevant studies were identified through systematic search of PubMed and Embase. A random-effect model was used to pool the results. Predefined subgroup analyses were performed to explore the source of heterogeneity. Five thousand seven hundred fourteen patients with ADHF and hyponatremia from eight cohort studies were included...
December 10, 2018: Heart Failure Reviews
Mohamed Hasham Varwani, Mohamed Jeilan, Mzee Ngunga, Anders Barasa
BACKGROUND: Coronary artery disease and its acute presentation are being increasingly recognised and treated in sub-Saharan Africa. It is just over a decade since the introduction of interventional cardiology for coronary artery disease in Kenya. Local and regional data, and indeed data from sub-Saharan Africa on long-term outcomes of acute coronary syndromes (ACS) are lacking. METHODS: A retrospective review of all ACS admissions to the Aga Khan University Hospital, Nairobi (AKUHN) between January 2012 and December 2013 was carried out to obtain data on patient characteristics, treatment and in-patient outcomes...
December 4, 2018: Cardiovascular Journal of Africa
Amit Bardia, Mabel Wai, Manuel L Fontes
PURPOSE OF REVIEW: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a relatively new class of drugs used in the management of diabetes mellitus. This review will highlight key pharmacologic characteristics of this class of drugs; discuss their potential role in management of patients with cardiac disease; and raise several perioperative concerns for anesthesiologists caring for patients on SGLT-2 inhibitors. RECENT FINDINGS: Recent trials have shown a strong mortality benefit in diabetic patients on SGLT 2 inhibitors especially in patients with a high cardiovascular burden...
December 6, 2018: Current Opinion in Anaesthesiology
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