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acute heart failure, mortality

Marwa Sayed Meshaal, Dina Labib, Karim Said, Mohammed Hosny, Mohammed Hassan, Said Abd Al Aziz, Amani Elkholy, Mervat Anani, Hussien Rizk
BACKGROUND: Fungal Endocarditis (FE), a relatively rare disease, has a high rate of mortality and is associated with multiple morbidities. Aspergillus endocarditis (AE) is severe form of FE. Incidence of AE has increased and is expected to rise due to an increased frequency of invasive procedures, cardiac devices and prosthetic valves together with increased use of immune system suppressors. AE lacks most of the clinical criteria used to diagnose infective endocarditis (IE), where blood culture is almost always negative, and fever may be absent...
2018: PloS One
Jorge Romero, Luigi Di Biase, Juan Carlos Diaz, Renato Quispe, Xianfeng Du, David Briceno, Ricardo Avendano, Usha Tedrow, Roy M John, Gregory F Michaud, Andrea Natale, William G Stevenson, Saurabh Kumar
OBJECTIVES: This was a meta-analysis of published studies to examine the impact of early referral on outcomes after catheter ablation for ventricular tachycardia (VT) in patients with structural heart disease. BACKGROUND: Patients are frequently referred for VT ablation after failure of antiarrhythmic drugs to control VT. Some studies have suggested that early referral might confer better outcomes. METHODS: An electronic search was performed using major databases...
March 2018: JACC. Clinical Electrophysiology
Vidar Ruddox, Jan Erik Otterstad, Dan Atar, Bjørn Bendz, Thor Edvardsen
OBJECTIVES: Patients surviving an acute myocardial infarction (AMI) are different today than when oral β-blockers first were shown to have an incremental effect on mortality. They are now, as opposed to then, offered revascularization procedures and effective secondary prevention. In this pilot-study, we aimed to explore the prescription of β-blockers to these patients stratified by their left ventricular ejection fraction (LVEF). METHODS: Consecutive stable patients treated with a percutaneous coronary intervention (PCI) procedure following an AMI were included for measurement of LVEF after 1-5 days...
August 8, 2018: Cardiology
Nobuyuki Kagiyama, Yuya Matsue
Acute heart failure (AHF) is a clinical syndrome with devastating prognosis. Despite considerable improvements in the treatment of chronic heart failure, most trials of new drugs for AHF, such as vasodilators, inotropes, and diuretics, have failed to show a prognostic benefit. Therefore, pharmacological treatment of AHF has changed very little, and loop diuretics have remained a cornerstone drug for decades. One of the emerging factors possibly playing an important role in AHF management is the time course of treatment...
August 2018: Anatolian Journal of Cardiology
Jan C van den Berge, Alina A Constantinescu, Ron T van Domburg, Milos Brankovic, Jaap W Deckers, K Martijn Akkerhuis
BACKGROUND: Renal dysfunction and anaemia are common in patients with acute heart failure (HF). It is not known whether their combined presence has additive prognostic value. We investigated their prognostic value separately and in combination, on prognosis in acute HF patients. Furthermore, we examined whether the improvement in prognosis was comparable between patients with and without renal dysfunction. METHODS AND RESULTS: This prospective registry includes 1783 patients admitted to the (Intensive) Coronary Care Unit for acute HF in the period of 1985-2008...
2018: PloS One
Zyad J Carr, Theodore J Cios, Kenneth F Potter, John T Swick
PURPOSE OF REVIEW: Postoperative cognitive dysfunction (POCD) occurs in 20-50% of postsurgical patients with a higher prevalence in elderly patients and patients with vascular disease and heart failure. In addition, POCD has been associated with many negative outcomes, such as increased hospital length of stay, increased rates of institutionalization, and higher patient mortality. This brief review discusses select evidence suggesting an association between neuroinflammation and POCD and whether the use of dexmedetomidine, a short-acting alpha 2 agonist, may ameliorate the incidence of POCD...
August 6, 2018: Current Neurology and Neuroscience Reports
Yugo Okabe, Takehiko Asaga, Sayuri Bekku, Hiromi Suzuki, Kanae Kanda, Takeshi Yoda, Tomohiro Hirao, Gotaro Shirakami
Background: Extubation failure is associated with mortality and morbidity in the intensive care unit. Ventilator weaning protocols have been introduced, and extubation is conducted based on the results of a spontaneous breathing trial. Room for improvement still exists in extubation management, and additional objective indices may improve the safety of the weaning and extubation process. Static lung-thorax compliance reflects lung expansion difficulty that is caused by several conditions, such as atelectasis, fibrosis, and pleural effusion...
2018: Journal of Intensive Care
Finlay A McAlister, Natasha Wiebe, Paul E Ronksley, Jeff S Healey
BACKGROUND: We investigated whether cardiovascular outcome patterns differ across atrial fibrillation (AF) subgroups defined by age, valvular status, newly diagnosed vs. prevalent cases, or anticoagulation status, and whether stroke risk models can accurately predict non-stroke outcomes. METHODS AND RESULTS: We performed a retrospective cohort study of all 147,952 adults with AF in Alberta, Canada between January 2008 and March 2014: 23,095 (15.6%) had at least one thromboembolic event (stroke, TIA, or systemic embolism) and 52,618 (35...
July 27, 2018: International Journal of Cardiology
Shijun Li, Salim Barywani, Michael Fu
Physical inactivity is very common in octogenarians. However, association between physical inactivity and mortality in octogenarians with acute coronary syndrome (ACS) remains unclear. In this study, we aimed to investigate association between physical inactivity and allcause mortality in octogenarian patients with ACS. In this study, we included a total of 353 hospitalized patients, aged >80 years, with ACS during the period of 5-year follow-up. The association between physical inactivity and all-cause mortality was analyzed by multivariable Cox aggression...
February 2018: Current medical science
Alwaleed Aljohar, Khalid F Alhabib, Tarek Kashour, Ahmad Hersi, Waleed Al Habeeb, Anhar Ullah, Abdelfatah Elasfar, Ali Almasood, Abdullah Ghabashi, Layth Mimish, Saleh Alghamdi, Ahmed Abuosa, Asif Malik, Gamal Abdin Hussein, Mushabab Al-Murayeh, Hussam AlFaleh
Background: The prognostic impact of hyperglycemia (HG) in acute heart failure (AHF) is controversial. Our aim is to examine the impact of HG on short- and long-term survival in AHF patients. Methods: Data from the Heart Function Assessment Registry Trial in Saudi Arabia (HEARTS) for patients who had available random blood sugar (RBS) were analyzed. The enrollment period was from October 2009 to December 2010. Comparisons were performed according to the RBS levels on admission as either <11...
October 2018: Journal of the Saudi Heart Association
Sumio Yamada, Takuji Adachi, Hideo Izawa, Toyoaki Murohara, Takaaki Kondo
BACKGROUND: Heart failure (HF) and frailty often co-exist, and frailty in HF results in a poor prognosis. However, in Asian populations, prognostic criteria are needed to examine the effect of frailty on HF. Therefore, we conducted a nationwide cohort study to develop frailty-based prognostic criteria in HF patients (FLAGSHIP). FLAGSHIP mainly aims to 1) develop the frailty criteria based on HF-specific outcomes, 2) propose a hypothesis of the potential mechanisms of frailty manifestations in HF, and 3) examine the effects of outpatient cardiac rehabilitation on frailty...
August 2, 2018: BMC Cardiovascular Disorders
David Brieger, John Amerena, John R Attia, Beata Bajorek, Kim H Chan, Cia Connell, Ben Freedman, Caleb Ferguson, Tanya Hall, Haris M Haqqani, Jeroen Hendriks, Charlotte M Hespe, Joseph Hung, Jonathan M Kalman, Prashanthan Sanders, John Worthington, Tristan Yan, Nicholas A Zwar
Atrial fibrillation (AF) is increasing in prevalence and is associated with significant morbidity and mortality. The optimal diagnostic and treatment strategies for AF are continually evolving and care for patients requires confidence in integrating these new developments into practice. These clinical practice guidelines will assist Australian practitioners in the diagnosis and management of adult patients with AF. Main recommendations: These guidelines provide advice on the standardised assessment and management of patients with atrial fibrillation regarding: screening, prevention and diagnostic work-up; acute and chronic arrhythmia management with antiarrhythmic therapy and percutaneous and surgical ablative therapies; stroke prevention and optimal use of anticoagulants; and integrated multidisciplinary care...
August 2, 2018: Medical Journal of Australia
Srikanth Yandrapalli, George Jolly, Medha Biswas, Yogita Rochlani, Prakash Harikrishnan, Wilbert S Aronow, Gregg M Lanier
Heart failure (HF) is characterized by maladaptive neurohormonal activation of the cardiovascular and renal systems resulting in circulatory inadequacy and frequent acute exacerbations. The increasing burden of HF prompted investigation of underlying pathophysiological mechanisms and the design of pharmacotherapeutics that would target these pathways. Areas covered: A MEDLINE search for relevant original investigations and review articles of newer hormonal drugs for HF since the year 2005 till October 2017 provided us with necessary literature...
January 2018: Expert Review of Endocrinology & Metabolism
Ásthildur Árnadóttir, Kirstine Roll Vestergaard, György Sölétormos, Rolf Steffensen, Jens P Goetze, Kasper Iversen
BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is a good prognostic marker for mortality. However, it is uncertain if hs-cTnT can be used to detect sub-clinical cardiac disease. METHOD: Pilot study in patients without known heart disease and elevated hs-cTnT measured at presentation to the emergency department. Hs-cTnT was measure with Roche Diagnostics. Echocardiography was used to assess structural heart disease and the participants underwent computed tomography angiography for assessment of coronary artery disease and agatston score...
July 30, 2018: European Journal of Clinical Investigation
Jihane Hajj, Natalie Blaine, Jola Salavaci, Douglas Jacoby
Sepsis is a serious and fatal medical condition that has overburdened the US healthcare system. The purpose of this paper is to provide a review of published literature on severe sepsis with a distinct focus on incidence, mortality, cost of hospital care, and postdischarge care. A review of the nature of postsepsis syndrome and its impact on septic patients is also included. The literature review was conducted utilizing the PubMed database, identifying 34 studies for inclusion. From the evaluation of these studies, it was determined that the incidence of sepsis continues to be on the rise according to three decades of epidemiological data...
July 30, 2018: Healthcare (Basel, Switzerland)
Hatice Selcuk, Mehmet Timur Selcuk, Orhan Maden, Kevser Gülcihan Balci, Mustafa Mücahit Balci, Sebahat Tekeli, Elif Hande Çetin, Ahmet Temizhan, Mustafa Balci, Nihal Karabiber
BACKGROUND: Although tremendous advances have been made in preventative and therapeutic approaches in heart failure (HF), the hospitalisation and mortality rates for patients with HF is high. The aim of this study was to investigate the association between cystatin C and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and in- and out-of-hospital mortality rates in acute decompensated HF (ADHF). METHODS: Between February 2008 and November 2011, 57 consecutive patients who were admitted with ADHF were included in this prospective study...
July 13, 2018: Cardiovascular Journal of Africa
Sven Möbius-Winkler, Michael Fritzenwanger, Rüdiger Pfeifer, P Christian Schulze
Patients in cardiogenic shock and acute heart failure show high mortality and morbidity despite aggressive and invasive methods such as percutaneous coronary intervention and the use of mechanical support devices. Percutaneous implantation of active hemodynamic support is often the only option for hemodynamic stabilization of patients in cardiogenic shock. Therefore, current guidelines support the use of these devices. Standardized protocols and clinical algorithms for the use of these support devices decrease mortality in these patients...
July 30, 2018: Heart Failure Reviews
Behcet Al, Mustafa Bogan, Suat Zengin, Mustafa Sabak, Seval Kul, M Murat Oktay, Hasan Bayram, Ertan Vuruskan
Objective: This study was designed to investigate the effects of Desert Dust Storms and Climatological Factors on Mortality and Morbidity of Cardiovascular Diseases admitted to emergency department in Gaziantep. Method: Hospital records, obtained between September 01, 2009 and January 31, 2014, from four state hospitals in Gaziantep, Turkey, were compared to meteorological and climatological data. Statistical analysis was performed by Statistical Package for the Social Science (SPSS) for windows version 24...
2018: Emergency Medicine International
Andriany Qanitha, Cuno S P M Uiterwaal, Jose P S Henriques, Idar Mappangara, Irfan Idris, Muzakkir Amir, Bastianus A J M de Mol
Objective: To measure medium-term outcomes and determine the predictors of mortality in patients with coronary artery disease (CAD) both during and after hospitalisation in a resource-limited South-East Asian setting. Methods: From February 2013 to December 2014, we conducted a prospective observational cohort study of 477 patients admitted to Makassar Cardiac Center, Indonesia, with acute coronary syndrome and stable CAD. We actively obtained data on clinical outcomes and after-discharge management until April 2017...
2018: Open Heart
Akira Kuriyama, Seigo Urushidani
Diuretic therapy is important in critically ill patients because fluid overload impairs organ function and increases mortality. Compared to intermittent administration, continuous infusion of loop diuretics is theoretically superior in terms of diuresis and electrolyte balance. However, the available evidence is susceptible to carryover diuretic effects and resistance in earlier crossover trials. Consequently, we conducted a systematic review and meta-analysis of parallel-group randomized controlled trials to compare these two strategies in adults with acute decompensated heart failure...
July 21, 2018: Heart Failure Reviews
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