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https://www.readbyqxmd.com/read/29149837/assessment-of-genetic-diversity-in-vigna-unguiculata-l-walp-accessions-using-inter-simple-sequence-repeat-issr-and-start-codon-targeted-scot-polymorphic-markers
#1
David Okeh Igwe, Celestine Azubike Afiukwa, Benjamin Ewa Ubi, Kenneth Idika Ogbu, Omena Bernard Ojuederie, George Nkem Ude
BACKGROUND: Assessment of genetic diversity of Vigna unguiculata (L.) Walp (cowpea) accessions using informative molecular markers is imperative for their genetic improvement and conservation. Use of efficacious molecular markers to obtain the required knowledge of the genetic diversity within the local and regional germplasm collections can enhance the overall effectiveness of cowpea improvement programs, hence, the comparative assessment of Inter-simple sequence repeat (ISSR) and Start codon targeted (SCoT) markers in genetic diversity of V...
November 17, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29149741/the-isolated-posterior-malleolar-fracture-and-syndesmotic-instability-a-case-report-and-review-of-the-literature
#2
Diederik P J Smeeing, Roderick M Houwert, Moyo C Kruyt, Falco Hietbrink
INTRODUCTION: Ankle fractures are among the most common type of fractures in the lower extremity. A posterior malleolar fracture is frequently part of a more complex ankle fracture and only in rare cases it occurs as isolated injury. Posterior malleolar fractures often occur with associated injuries, such as a Maisonneuve fracture or with bi- or trimalleolar ligamentous injuries. Knowledge about these associated injuries is essential to prevent missed diagnoses. The aim of this article is to describe the isolated posterior malleolar fracture, the possible associated injuries, the diagnostic work-up and therapeutic consequences...
November 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29149634/patient-participation-in-nursing-bedside-handover-a-systematic-mixed-methods-review
#3
REVIEW
Georgia Tobiano, Tracey Bucknall, Ishtar Sladdin, Jennifer A Whitty, Wendy Chaboyer
BACKGROUND: Numerous reviews of nursing handover have been undertaken, but none have focused on the patients' role. OBJECTIVES: To explore how patient participation in nursing shift-to-shift bedside handover can be enacted. DESIGN: Systematic mixed- methods review. DATA SOURCES: Three search strategies were undertaken in July-August 2016: database searching, backwards citation searching and forward citation searching...
October 24, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29149507/registered-nurse-and-midwife-experiences-of-using-videoconferencing-in-practice-a-systematic-review-of-qualitative-studies
#4
REVIEW
Robyn A Penny, Natalie K Bradford, Danette Langbecker
AIM: To synthesise evidence of registered nurses' and midwives' experiences with videoconferencing and identify perceptions of the appropriateness, meaningfulness and feasibility of this technology in professional and clinical practice. BACKGROUND: Videoconferencing is a form of telehealth that can facilitate access to high quality care to improve health outcomes for patients and enable clinicians working in isolation to access education, clinical supervision, peer support and case review...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29149350/a-data-fusion-pipeline-for-generating-and-enriching-adverse-outcome-pathway-descriptions
#5
Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen, Roland C Grafström
Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome Pathway (AOP) descriptions could potentially aid the development of non-animal based hazard and risk assessment methods. We devised a six-step workflow that integrated diverse types of toxicology data into a novel AOP scheme for pulmonary fibrosis. Mining of literature references and diverse data sources covering previous pathway descriptions and molecular results were coupled in a stepwise manner with informatics tools applications that enabled gene linkage and pathway identification in molecular interaction maps...
November 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29148876/food-safety-at-farmers-markets-a-knowledge-synthesis-of-published-research
#6
Ian Young, Abhinand Thaivalappil, Danielle Reimer, Judy Greig
Farmers' markets are increasingly popular venues in North America for the sale of fresh produce and other foods. However, the nature of their operation can present possible food safety issues, challenges, and risks to consumers. A knowledge synthesis was conducted to identify, characterize, and summarize published research on the microbial food safety issues and implications associated with farmers' markets. A scoping review was conducted using the following steps: comprehensive search strategy, relevance screening of abstracts, and characterization of relevant articles...
November 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29148579/a-step-by-step-review-on-patient-specific-biomechanical-finite-element-models-for-breast-mri-to-x-ray-mammography-registration
#7
REVIEW
Eloy García, Yago Diez, Oliver Diaz, Xavier Lladó, Robert Martí, Joan Martí, Arnau Oliver
Breast magnetic resonance imaging (MRI) and X-ray mammography are two image modalities widely used for the early detection and diagnosis of breast diseases in women. The combination of these modalities leads to a more accurate diagnosis and treatment of breast diseases. The aim of this paper is to review the registration between breast MRI and X-ray mammographic images using patient-specific finite element-based biomechanical models. Specifically, a biomechanical model is obtained from the patient's MRI volume and is subsequently used to mimic the mammographic acquisition...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29148114/on-the-character-and-production-of-active-participation-in-neuro-rehabilitation-an-actor-network-perspective
#8
Simon Horton, Kathryn Mares, Neil Coull, Fiona Poland
The importance of patients' active involvement in neuro-rehabilitation after acquired brain injury has been consistently emphasised in recent years. However, most approaches fail to show how 'active participation' is practically enacted, focusing on individualised explanations of patient choice and behaviours, or notions of inherent patient traits. Using actor-network theory (ANT) as a sensitising concept, we investigated neuro-rehabilitation practices, asking how participation is shaped through biological and socio-material specificities, how rights to knowledge and expertise are constructed, and how a body acclimatises and adjusts within an order of participation and transformation...
November 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29148103/extracytoplasmic-function-sigma-factor-%C3%AF-d-confers-resistance-to-environmental-stress-by-enhancing-mycolate-synthesis-and-modifying-peptidoglycan-structures-in-corynebacterium-glutamicum
#9
Koichi Toyoda, Inui Masayuki
Mycolates are α-branched, β-hydroxylated, long-chain fatty acid specifically synthesized in bacteria in the suborder Corynebacterineae of the phylum Actinobacteria. They form an outer membrane, which functions as a permeability barrier and confers pathogenic mycobacteria to resistance to antibiotics. Although the mycolate biosynthetic pathway has been intensively studied, knowledge of transcriptional regulation of genes involved in this pathway is limited. Here we report that the extracytoplasmic function sigma factor σ(D) is a key regulator of the mycolate synthetic genes in Corynebacterium glutamicum in the suborder...
November 17, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29145615/iptmnet-an-integrated-resource-for-protein-post-translational-modification-network-discovery
#10
Hongzhan Huang, Cecilia N Arighi, Karen E Ross, Jia Ren, Gang Li, Sheng-Chih Chen, Qinghua Wang, Julie Cowart, K Vijay-Shanker, Cathy H Wu
Protein post-translational modifications (PTMs) play a pivotal role in numerous biological processes by modulating regulation of protein function. We have developed iPTMnet (http://proteininformationresource.org/iPTMnet) for PTM knowledge discovery, employing an integrative bioinformatics approach-combining text mining, data mining, and ontological representation to capture rich PTM information, including PTM enzyme-substrate-site relationships, PTM-specific protein-protein interactions (PPIs) and PTM conservation across species...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29144773/cancer-chemopreventive-antiproliferative-and-superoxide-anion-scavenging-properties-of-kluyveromyces-marxianus-and-saccharomyces-cerevisiae-var-boulardii-cell-wall-components
#11
Olivier Fortin, Blanca Aguilar-Uscanga, Khanh Dang Vu, Stephane Salmieri, Monique Lacroix
This study investigated the cancer chemopreventive, the antiradical, and the antiproliferative properties of polysaccharides extracts from cell wall of Saccharomyces boulardii and Kluyveromyces marxianus. β-glucan, mannan, and chitin were also quantified to identify the most important extract responsible for these biological properties. Soluble and insoluble glucans as well as mannoprotein were extracted from cell wall using single hot-alkaline method. Superoxide anion scavenging (antiradical capacity), NAD(P)H: quinone reductase (QR) (EC 1...
November 16, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29144545/music-therapy-for-depression
#12
REVIEW
Sonja Aalbers, Laura Fusar-Poli, Ruth E Freeman, Marinus Spreen, Johannes Cf Ket, Annemiek C Vink, Anna Maratos, Mike Crawford, Xi-Jing Chen, Christian Gold
BACKGROUND: Depression is a highly prevalent mood disorder that is characterised by persistent low mood, diminished interest, and loss of pleasure. Music therapy may be helpful in modulating moods and emotions. An update of the 2008 Cochrane review was needed to improve knowledge on effects of music therapy for depression. OBJECTIVES: 1. To assess effects of music therapy for depression in people of any age compared with treatment as usual (TAU) and psychological, pharmacological, and/or other therapies...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29144161/use-of-patient-outcome-endpoints-to-identify-the-best-functional-ct-imaging-parameters-in-metastatic-renal-cell-carcinoma-patients
#13
Jill Rachel Mains, Frede Donskov, Erik Morre Petersen, Hans Henrik Torp Madsen, Jesper Thygesen, Kennet Thorup, Finn Rasmussen
OBJECTIVE: To use the patient outcome endpoints overall survival and progression-free survival to evaluate functional parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT). METHODS: 69 patients with metastatic renal cell carcinoma (mRCC) had DCE-CT scans at baseline and after 5 and 10 weeks of treatment. Blood volume, blood flow and standardized perfusion values were calculated using deconvolution (BVdeconv, BFdeconv and SPVdeconv), blood flow and standardized perfusion values using maximum slope (BFmax and SPVmax), and blood volume and permeability surface area product using the Patlak model (BVpatlak and PS)...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29142381/nursing-management-of-adults-with-severe-traumatic-brain-injury-a-narrative-review
#14
REVIEW
Roseminu Varghese, Jyothi Chakrabarty, Girish Menon
Effective nursing management strategies for adults with severe traumatic brain injury (STBI) are still a remarkable issue and a difficult task for neurologists, neurosurgeons, and neuronurses. A list of justified indications and scientific rationale for nursing management of these patients are continuously evolving. The objectives of the study are to analyze the pertinently available research and clinical studies that demonstrate the nursing management strategies for adults with STBI and to synthesize the available evidence based on the review...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29142060/sleep-increases-explicit-solutions-and-reduces-intuitive-judgments-of-semantic-coherence
#15
Thea Zander, Kirsten G Volz, Jan Born, Susanne Diekelmann
Sleep fosters the generation of explicit knowledge. Whether sleep also benefits implicit intuitive decisions about underlying patterns is unclear. We examined sleep's role in explicit and intuitive semantic coherence judgments. Participants encoded sets of three words and after a sleep or wake period were required to judge the potential convergence of these words on a common fourth associate. Compared with wakefulness, sleep increased the number of explicitly named common associates and decreased the number of intuitive judgments...
December 2017: Learning & Memory
https://www.readbyqxmd.com/read/29141621/expectations-and-perceptions-of-primary-healthcare-professionals-regarding-their-own-continuous-education-in-catalonia-spain-a-qualitative-study
#16
Xavier Mundet-Tuduri, Ramon Crespo, Ma Luisa Fernandez-Coll, Montserrat Saumell, Flor Millan-Mata, Àngels Cardona, Núria Codern-Bové
BACKGROUND: The planning and execution of continuous education in an organization that provides health services is a complex process. The objectives, learning sequences, and implementation strategies should all be oriented to improving the health of the population. The aim of this study was to analyse the expectations and perceptions of continuous educations by primary healthcare professionals (physicians and nurses) and identify aspects that hinder or encourage the process. METHODS: A qualitative study with 5 focus groups made up of 25 primary healthcare professionals from the Catalan Health Institute, Barcelona (Catalonia, Spain)...
November 15, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29139208/a-knowledge-based-approach-to-automated-planning-for-hepatocellular-carcinoma
#17
Yujie Zhang, Tingting Li, Han Xiao, Weixing Ji, Ming Guo, Zhaochong Zeng, Jianying Zhang
PURPOSE: To build a knowledge-based model of liver cancer for Auto-Planning, a function in Pinnacle, which is used as an automated inverse intensity modulated radiation therapy (IMRT) planning system. METHODS AND MATERIALS: Fifty Tomotherapy patients were enrolled to extract the dose-volume histograms (DVHs) information and construct the protocol for Auto-Planning model. Twenty more patients were chosen additionally to test the model. Manual planning and automatic planning were performed blindly for all twenty test patients with the same machine and treatment planning system...
November 15, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29138816/protective-effects-of-fucoidan-against-hyperoxic-lung-injury-via-the-erk-signaling-pathway
#18
Minghao Nie, Yan Wang, Yanhong Lu, Ying Yuan, Yingying Liu, Xiurong Li
High oxygen mechanical ventilation is widely used to treat various lung diseases; however, it may result in hyperoxia, which induces inflammation and lung injury. Fucoidan is an extract of the seaweed Fucus vesiculosus, which has previously been reported to exert effects against diabetic nephropathy. The present study is the first, to the best of our knowledge, to investigate the protective effects of fucoidan against hyperoxic lung injury. Balb/c mice were ventilated with 100% oxygen, with or without the atomization inhalation of fucoidan, for 36 h...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29137809/prognostic-factors-for-local-recurrence-of-squamous-cell-carcinoma-of-the-vulva-a-systematic-review
#19
Nienke C Te Grootenhuis, Anne-Floor W Pouwer, Geertruida H de Bock, Harry Hollema, Johan Bulten, Ate G J van der Zee, Joanne A de Hullu, Maaike H M Oonk
BACKGROUND: In patients treated for early-stage squamous cell vulvar carcinoma local recurrence is reported in up to 40% after ten years. Knowledge on prognostic factors related to local recurrences should be helpful to select high risk patients and/or to develop strategies to prevent local recurrences. OBJECTIVE: This systematic review aims to evaluate the current knowledge on the incidence of local recurrences in vulvar carcinoma related to clinicopathologic and cell biologic variables...
November 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29137659/the-effectiveness-of-research-implementation-strategies-for-promoting-evidence-informed-policy-and-management-decisions-in-healthcare-a-systematic-review
#20
REVIEW
Mitchell N Sarkies, Kelly-Ann Bowles, Elizabeth H Skinner, Romi Haas, Haylee Lane, Terry P Haines
BACKGROUND: It is widely acknowledged that health policy and management decisions rarely reflect research evidence. Therefore, it is important to determine how to improve evidence-informed decision-making. The primary aim of this systematic review was to evaluate the effectiveness of research implementation strategies for promoting evidence-informed policy and management decisions in healthcare. The secondary aim of the review was to describe factors perceived to be associated with effective strategies and the inter-relationship between these factors...
November 14, 2017: Implementation Science: IS
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