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https://www.readbyqxmd.com/read/28525369/association-between-serum-resistin-concentration-and-hypertension-a-systematic-review-and-meta-analysis
#1
Yuxiang Zhang, Yixing Li, Lin Yu, Lei Zhou
OBJECTIVES: Recent studies have suggested the involvement of adipokines in the pathogenesis of cardiovascular diseases, including hypertension. In this study, we evaluated the significance of serum resistin levels in hypertensive patients using a meta-analysis approach. MATERIALS AND METHODS: Relevant articles were retrieved by searching the following databases: PubMed, Embase, Ovid Medline, ISI Web of Knowledge. The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28523614/two-important-limitations-relating-to-the-spiking-of-environmental-samples-with-contaminants-of-emerging-concern-how-close-to-the-real-analyte-concentrations-are-the-reported-recovered-values
#2
Costas Michael, Josep Maria Bayona, Dimitra Lambropoulou, Ana Agüera, Despo Fatta-Kassinos
Occurrence and effects of contaminants of emerging concern pose a special challenge to environmental scientists. The investigation of these effects requires reliable, valid, and comparable analytical data. To this effect, two critical aspects are raised herein, concerning the limitations of the produced analytical data. The first relates to the inherent difficulty that exists in the analysis of environmental samples, which is related to the lack of knowledge (information), in many cases, of the form(s) of the contaminant in which is present in the sample...
May 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28522217/celastrol-inhibits-chondrosarcoma-proliferation-migration-and-invasion-through-suppression-cip2a-c-myc-signaling-pathway
#3
Jinhui Wu, Muchen Ding, Ningfang Mao, Yungang Wu, Chao Wang, Jiabin Yuan, Xiong Miao, Jingfeng Li, Zhicai Shi
Chondrosarcomas (CS) is the second most frequent tumors of cartilage origin. A small compound extracted from Thunder God Vine (Tripterygium wilfordii Hook. F.) called celastrol can directly bound CIP2A protein and effectively inhibit cell proliferation and induce apoptosis in several cancer cells. However, little knowledge is concern about the important role of CIP2A in CS patients and the therapeutic value of celastrol on CS. Our results showed that CIP2A and c-MYC were verified to be oncoproteins by detecting their mRNA and protein expression in 10 human CS tissues by qRT-PCR and Western blots...
April 14, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28521963/does-local-delivery-of-bisphosphonates-influence-the-osseointegration-of-titanium-implants-a-systematic-review
#4
REVIEW
M B Guimarães, T H Antes, M B Dolacio, D D Pereira, M Marquezan
The aim of this study was to systematically review the influence of the local delivery of bisphosphonates on the osseointegration of titanium implants in humans. A search of health sciences databases was performed (The Cochrane Library, Embase, PubMed MEDLINE, ISI Web of Knowledge, Scopus, and SIGLE OpenGrey), including articles published until October 2016. A total of 679 articles were identified. Following the removal of duplicates, 278 were screened by title and abstract. The complete texts of seven studies were read, and of these, three met the inclusion criteria...
May 15, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28518108/identification-of-plant-ice-binding-proteins-through-assessment-of-ice-recrystallization-inhibition-and-isolation-using-ice-affinity-purification
#5
Melissa Bredow, Heather E Tomalty, Virginia K Walker
Ice-binding proteins (IBPs) belong to a family of stress-induced proteins that are synthesized by certain organisms exposed to subzero temperatures. In plants, freeze damage occurs when extracellular ice crystals grow, resulting in the rupture of plasma membranes and possible cell death. Adsorption of IBPs to ice crystals restricts further growth by a process known as ice-recrystallization inhibition (IRI), thereby reducing cellular damage. IBPs also demonstrate the ability to depress the freezing point of a solution below the equilibrium melting point, a property known as thermal hysteresis (TH) activity...
May 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28515182/health-assets-in-older-age-a-systematic-review
#6
Yvonne Claire Hornby-Turner, Nancye May Peel, Ruth Eleanor Hubbard
BACKGROUND: Finding ways to optimise health in older age is key to reducing the impact of population ageing on health and social care systems. A salutogenic approach takes into account an individual's health assets-internal or external strengths or accessible resources which improve and preserve physical, social and mental wellness, independence and quality of life. The aim of this narrative systematic review was to provide a summary and appraisal of the evidence for factors that act as health assets within personal, social, economic and environmental domains...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28514737/integration-of-phytochemicals-and-phytotherapy-into-cancer-precision-medicine
#7
REVIEW
Thomas Efferth, Mohamed E M Saeed, Elhaj Mirghani, Awadh Alim, Zahir Yassin, Elfatih Saeed, Hassan E Khalid, Salah Daak
Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28513340/questions-about-cervical-and-breast-cancer-screening-knowledge-practice-and-outcomes-a-review-of-demographic-and-health-surveys
#8
Laura Viens, Doug Perin, Virginia Senkomago, Antonio Neri, Mona Saraiya
United Nation's Sustainable Development Goals and the World Health Organization's Global Monitoring Framework support a strong global commitment to reducing the high burden of cervical and breast cancers among low- and middle-income countries. Strategies include vaccination, screening, and early diagnosis. Population-based surveys, such as those conducted by the Demographic and Health Surveys (DHS) Program, can collect the information needed to guide cancer control efforts in a standardized comparable manner...
May 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28512597/documentation-of-ethnomedicinal-information-and-antimicrobial-validation-of-thespesia-populnea-used-by-yanadi-tribe-of-ganugapenta-village-chittoor-district-andhra-pradesh-india
#9
Nataru Savithramma, Pulicherla Yugandhar, Pallipati Suvarnalatha Devi, Sade Ankanna, Damai Suhrulatha, Koya Siva Prasad, Ramakrishanan Ranjani, Nagoji Nagaraju, Kummara Madhava Chetty
AIM: This study aimed to document the traditional knowledge of medicinal plants and antimicrobial validation of Thespesia populnea used by Yanadi tribe of Chittoor district, Andhra Pradesh, India. MATERIALS AND METHODS: The study was mainly focused on documentation of medicinal plants used by Yanadi tribe to treat different diseases with a standard questionnaire. These plants were cross-checked in Dr. Dukes Database and available literature to know the significance of this tribe on medicinal knowledge...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512371/first-report-of-the-spiral-nematode-helicotylenchus-microlobus-infecting-soybean-in-north-dakota
#10
Guiping Yan, Addison Plaisance, Danqiong Huang, Zafar A Handoo
Spiral nematodes (Helicotylenchus spp.) are common plant-parasitic nematodes in fields of many crops. In June 2015, two soil samples were collected from a soybean field in Richland County, ND. Nematodes were extracted from soil using the sugar centrifugal flotation method (Jenkins, 1964). Plant-parasitic nematodes were identified to genus based on morphological features and counted. Both samples contained spiral nematodes from 1,500 to 3,300 per kilogram of soil. In June and August 2016, 10 soil samples were collected from the same field...
March 2017: Journal of Nematology
https://www.readbyqxmd.com/read/28511589/a-semi-automatic-method-for-the-extraction-of-the-portal-venous-input-function-in-quantitative-dynamic-contrast-enhanced-ct-of-the-liver
#11
Andrew B Gill, Nicholas J Hilliard, Simon T Hilliard, Martin Graves, David J Lomas, Ashley Shaw
OBJECTIVES: To aid the extraction of the portal venous input function (PVIF) from axial dynamic contrast-enhanced CT images of the liver, eliminating the need for full manual outlining of the vessel across time-points. METHODS: A cohort of 20 patients undergoing perfusion CT imaging of the liver were examined. Dynamic images of the liver were reformatted into contiguous thin slices. A region of interest (ROI) was defined within a transverse section of the portal vein on a single contrast-enhanced image...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28511405/evaluation-of-acute-oral-toxicity-of-ethanol-leaves-extract-of-catharanthus-roseus-in-wistar-albino-rats
#12
Venkateswar Rao Vutukuri, M C Das, Muralidhar Reddy, Siva Prabodh, Padma Sunethri
INTRODUCTION: Herbal drugs have gained importance globally in the treatment of various diseases. Catharanthus roseus is traditionally used as an anti diabetic and anti cancer drug. To the best of our knowledge limited data are available on acute and sub acute toxicity of C. roseus extract despite its wide spread use in traditional medicine. The present study was under taken to evaluate the acute oral toxicity of the ethanol leaves extract of C. roseus. AIM: To investigate the acute oral toxic effects of ethanol leaves extract of C...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509897/disambiguation-of-patent-inventors-and-assignees-using-high-resolution-geolocation-data
#13
Greg Morrison, Massimo Riccaboni, Fabio Pammolli
Patent data represent a significant source of information on innovation, knowledge production, and the evolution of technology through networks of citations, co-invention and co-assignment. A major obstacle to extracting useful information from this data is the problem of name disambiguation: linking alternate spellings of individuals or institutions to a single identifier to uniquely determine the parties involved in knowledge production and diffusion. In this paper, we describe a new algorithm that uses high-resolution geolocation to disambiguate both inventors and assignees on about 8...
May 16, 2017: Scientific Data
https://www.readbyqxmd.com/read/28509615/mining-of-a-phospholipase-d-and-its-application-in-enzymatic-preparation-of-phosphatidylserine
#14
Wen-Bin Zhou, Jin-Song Gong, Hai-Juan Hou, Heng Li, Zhen-Ming Lu, Hong-Yu Xu, Zheng-Hong Xu, Jin-Song Shi
Phosphatidylserine (PS) is useful as the additive in industries for memory improvement, mood enhancement and drug delivery. Conventionally, PS was extracted from soybeans, vegetable oils, egg yolk, and biomass; however, their low availability and high extraction cost were limiting factors. Phospholipase D (PLD) is a promising tool for enzymatic synthesis of PS due to its transphosphatidylation activity. In this contribution, a new and uncharacterized PLD was first obtained from GenBank database via genome mining strategy...
May 16, 2017: Bioengineered
https://www.readbyqxmd.com/read/28509515/understanding-avoidance-and-non-attendance-among-adolescents-in-dental-care-an-integrative-review
#15
A Fägerstad, J Windahl, K Arnrup
OBJECTIVE: To review articles exploring manifestations of avoidance of or non-attendance to dental care, to identify background and concomitant factors specifically associated with dental avoidance among adolescents. METHODS: PubMed, CINAHL and PsychINFO were searched using MeSH terms and keywords covering dental avoidance, non-attendance and non-utilization. Searches were limited to peer-reviewed studies in English, published in 1994-2014. Twenty-one research articles were included...
September 2016: Community Dental Health
https://www.readbyqxmd.com/read/28507542/reactive-oxygen-species-mediated-cellular-stress-response-and-lipid-accumulation-in-oleaginous-microorganisms-the-state-of-the-art-and-future-perspectives
#16
REVIEW
Kun Shi, Zhen Gao, Tian-Qiong Shi, Ping Song, Lu-Jing Ren, He Huang, Xiao-Jun Ji
Microbial oils, which are mainly extracted from yeasts, molds, and algae, have been of considerable interest as food additives and biofuel resources due to their high lipid content. While these oleaginous microorganisms generally produce only small amounts of lipids under optimal growth conditions, their lipid accumulation machinery can be induced by environmental stresses, such as nutrient limitation and an inhospitable physical environmental. As common second messengers of many stress factors, reactive oxygen species (ROS) may act as a regulator of cellular responses to extracellular environmental signaling...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28506862/a-relevant-mid-term-12-months-placebo-effect-on-lower-urinary-tract-symptoms-and-maximum-flow-rate-in-male-luts-bph-a-meta-analysis
#17
Klaus Eredics, Stephan Madersbacher, Ingrid Schauer
OBJECTIVE: To assess the mid- to long-term placebo effect of medical and instrumental management of male lower urinary tract symptoms (LUTS). This is - generally - a long-term treatment strategy. Therefore, knowledge on the mid- to long-term placebo effect is of considerable interest. The paucity of data on this topic prompted us to investigate this issue in a meta-analysis. METHODS: All randomized controlled trials (RCTs) with the indication BPH/LUTS containing a placebo- or sham treatment arm and with a follow-up of 12 months were eligible...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28506565/the-antifungal-activity-of-moroccan-plants-and-the-mechanism-of-action-of-secondary-metabolites-from-plants
#18
REVIEW
F Lagrouh, N Dakka, Y Bakri
This review is based on a comprehensive literature search for existing knowledge about antifungal mechanisms of different secondary metabolites from plants. The secondary metabolites have been grouped into three major groups according to their biosynthetic origin. On another side, this review represents studies on antifungal activity of essential oils and extracts from Moroccan plants, against fungal species involved in human or plant diseases.
May 11, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28505889/vegetation-dynamics-and-responses-to-climate-change-and-human-activities-in-central-asia
#19
Liangliang Jiang, Guli Jiapaer, Anming Bao, Hao Guo, Felix Ndayisaba
Knowledge of the current changes and dynamics of different types of vegetation in relation to climatic changes and anthropogenic activities is critical for developing adaptation strategies to address the challenges posed by climate change and human activities for ecosystems. Based on a regression analysis and the Hurst exponent index method, this research investigated the spatial and temporal characteristics and relationships between vegetation greenness and climatic factors in Central Asia using the Normalized Difference Vegetation Index (NDVI) and gridded high-resolution station (land) data for the period 1984-2013...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28505320/graph-based-semi-supervised-learning-with-genomic-data-integration-using-condition-responsive-genes-applied-to-phenotype-classification
#20
Abolfazl Doostparast Torshizi, Linda R Petzold
Objective: Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects of different biological data types can boost learning capabilities and lead to a better understanding of the underlying interactions among molecular levels. Methods: In this paper we present a graph-based semi-supervised classification algorithm that incorporates latent biological knowledge in the form of biological pathways with gene expression and DNA methylation data...
May 13, 2017: Journal of the American Medical Informatics Association: JAMIA
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