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Kaitlyn B Gam, Lawrence S Engel, Richard K Kwok, Matthew D Curry, Patricia A Stewart, Mark R Stenzel, John A McGrath, W Braxton Jackson, Maureen Y Lichtveld, Dale P Sandler
INTRODUCTION: Oil spill response and cleanup (OSRC) workers had potentially stressful experiences during mitigation efforts following the 2010 Deepwater Horizon disaster. Smelling chemicals; skin or clothing contact with oil; heat stress; handling oily plants/wildlife or dead animal recovery; and/or being out of regular work may have posed a risk to worker respiratory health through psychological stress mechanisms. OBJECTIVE: To evaluate the association between six potentially stressful oil spill experiences and lung function among OSRC workers 1-3 years following the Deepwater Horizon disaster, while controlling for primary oil spill inhalation hazards and other potential confounders...
October 11, 2018: Environment International
Luc Dauchet, Sébastien Hulo, Nathalie Cherot-Kornobis, Régis Matran, Philippe Amouyel, Jean-Louis Edmé, Jonathan Giovannelli
INTRODUCTION: Air pollution impacts health by increasing mortality and the incidence of acute events in unhealthy individuals. In contrast, the acute effects of pollution in healthy individuals are less obvious. The present study was designed to evaluate the associations between short-term exposure to air pollution on one hand and lung function, and inflammatory markers on the other in middle-aged, non-smoking adults with no respiratory disease, in two urban areas in northern France. METHODS: A sample of 1506 non-smoking adults (aged from 40 to 65) with no respiratory disease was selected from the participants in the 2011-2013 cross-sectional Enquête Littoral Souffle Air Biologie Environnement (ELISABET) survey in two urban areas in the northern France...
October 9, 2018: Environment International
Pavol Sajgalik, Chul-Ho Kim, John M Stulak, Sudhir S Kushwaha, Simon Maltais, David L Joyce, Lyle D Joyce, Bruce D Johnson, John A Schirger
AIM: The lungs-and particularly the alveolar-capillary membrane-may be sensitive to continuous flow (CF) and pulmonary pressure alterations in heart failure (HF). We aimed to investigate long-term effects of CF pumps on respiratory function. METHODS AND RESULTS: We conducted a retrospective study of patients with end-stage HF at our institution. We analysed pulmonary function tests [e.g. forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1 )] and diffusing capacity of the lung for carbon monoxide (DLCO ) from before and after left ventricular assist device (LVAD) implantation and compared them with invasive haemodynamic studies...
October 12, 2018: ESC Heart Failure
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Bastian Schmack, Fabrice F Darche, Dierk Thomas, Tom Bruckner, Hugo A Katus, Philipp Ehlermann, Andreas O Doesch
Objectives: COPD is associated with reduced physical activity, an increased risk for pulmonary infections, and impaired survival in nontransplant patients. The aim of this study was to investigate the influence of COPD in patients after heart transplantation (HTX). Methods: We performed an observational retrospective single-center study of 259 patients receiving HTX at Heidelberg University Hospital between 2003 and 2012. Patients were stratified by the Tiffeneau index (forced expiratory volume in 1 second/forced vital capacity [FEV1/FVC]) <0...
2018: Clinical Epidemiology
Freke A Wilmink, Herman T den Dekker, Johan C de Jongste, I Reiss, Vincent W V Jaddoe, Eric A Steegers, Liesbeth Duijts
Preeclampsia is associated with an increased risk of bronchopulmonary dysplasia, wheezing and asthma in later childhood. Currently, there are no studies available investigating maternal blood pressure measurements during multiple time points in pregnancy and respiratory outcome measures in the child. We examined the associations of maternal blood pressure and hypertensive disorders with the risk of lower lung function, wheezing and asthma in children aged 10 years. This study among 4894 children was embedded in a population-based prospective cohort study...
October 11, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Andrés Ledesma Velázquez, David Castro Serna, Germán Vargas Ayala, Angélica Paniagua Pérez, Ivan Meneses Acero, Saúl Huerta Ramírez
BACKGROUND AND OBJECTIVE: Diabetes mellitus can affect the lungs, in its various structures and functions. Current research is being conducted to establish the clinical impact of hyperglycaemia on lung function. The objective of this study is to determine if the glycaemic state (euglycaemic, prediabetes or diabetes) is associated with a decrease in lung volume, determined by spirometry. PATIENTS AND METHODS: An analytical cross-sectional study was carried out at the Ticomán General Hospital in Mexico City...
October 8, 2018: Medicina Clínica
Marcelo Cardoso Barros, Bruno Hochhegger, Stephan Altmayer, Guilherme Watte, Matheus Zanon, Ana Paula Sartori, Daniela Cavalet Blanco, Gabriel Sartori Pacini, Jose Miguel Chatkin
OBJECTIVE: To evaluate the quantitative computed tomography (QCT) phenotypes, airflow limitations, and exacerbation-like episodes in heavy smokers in Southern Brazil. METHODS: We enrolled 172 smokers with a smoking history ≥30 pack-years who underwent pulmonary function tests (PFTs) and CT scan for lung cancer screening. Patients were classified regarding airflow limitation (FEV1/FVC <0.7 forced expiratory volume in 1 second/forced vital capacity) and the presence of emphysema on the QCT...
2018: PloS One
Shikma Katz, Nissim Arish, Ariel Rokach, Yacov Zaltzman, Esther-Lee Marcus
BACKGROUND: Pulmonary function tests (PFTs) are routinely performed in the upright position due to measurement devices and patient comfort. This systematic review investigated the influence of body position on lung function in healthy persons and specific patient groups. METHODS: A search to identify English-language papers published from 1/1998-12/2017 was conducted using MEDLINE and Google Scholar with key words: body position, lung function, lung mechanics, lung volume, position change, positioning, posture, pulmonary function testing, sitting, standing, supine, ventilation, and ventilatory change...
October 11, 2018: BMC Pulmonary Medicine
Gregory J Redding, Heidi Hurn, Klane K White, Viviana Bompadre, Julia Emerson, R Zachary Garza, Kendall Anigian, John Waldhausen, Walter Krengel, Ajeya Joshi
BACKGROUND: Obstructive lung disease occurs in 30% of children with early onset scoliosis (EOS); changes in degree of airway obstruction over time have not been reported. METHODS: Longitudinal patterns of incidental, persistent, and progressive airway obstruction were retrospectively analyzed in a cohort of children with EOS with at least 1 forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) value <85% on serial spirometric assessments over a ≥3-year observation period...
October 8, 2018: Journal of Pediatric Orthopedics
Jared S Magee, Luke M Pittman, Leslie A Jette-Kelly
BACKGROUND Asthma is a common disease in the U.S. POPULATION: Initial therapy in the stepwise approach for asthma management is short-acting β₂-agonist (SABA) therapy as needed for symptom control. However, a significant adverse event that can occur with administration is bronchospasm. Here, we report a case of paradoxical bronchospasm with administration of SABAs during multiple pulmonary function tests (PFTs). CASE REPORT A 25-year-old, non-smoking, African American male with a history of moderate asthma and allergic rhinitis treated with fluticasone/salmeterol diskus, albuterol hydrofluoroalkane (HFA) inhaler, and montelukast presented to our clinic complaining of recurrent episodes of acute shortness of breath immediately following each administration of albuterol for 4 weeks...
October 9, 2018: American Journal of Case Reports
Lusine Ambartsumyan, Hengqi B Zheng, Ramesh S Iyer, Jennifer Soares, Gretchen Henstorf, Anne M Stevens
OBJECTIVE: Juvenile systemic sclerosis (jSSc) is a disabling autoimmune condition that affects multiple organs in addition to skin, notably the gastrointestinal and pulmonary systems. The relationship between esophageal abnormalities and pulmonary disease in jSSc is not well understood. We describe associations between radiologic esophageal abnormalities and pulmonary function. METHODS: Clinical and radiographic data of children less than 18 years who fulfilled 2007 Pediatric Rheumatology Provisional Classification Criteria for jSSc between 1994 and 2016 were reviewed...
October 8, 2018: Arthritis Care & Research
Samuel Ademola Adegoke, Bankole Peter Kuti, Kehinde Oluyori Omole, Olufemi Samuel Smith, Oyeku Akibu Oyelami, Oluwagbemiga Oyewole Adeodu
BACKGROUND: Sickle cell anaemia (SCA) is a chronic inflammatory disorder with multiple organ manifestations including acute and long-term pulmonary dysfunction. AIMS/OBJECTIVES: To assess lung function of children with SCA and determine the possible role of acute chest syndrome (ACS), serum inflammatory cytokines, highly sensitive C-reactive protein (hs-CRP), leucocytes and 25-hydroxyvitamin D on the development of impaired lung function. SUBJECTS AND METHODS: Lung function of 76 children with SCA was determined by spirometer and classified into normal or impaired...
October 8, 2018: Paediatrics and International Child Health
Brooks W Morgan, Matthew R Grigsby, Trishul Siddharthan, Muhammad Chowdhury, Adolfo Rubinstein, Laura Gutierrez, Vilma Irazola, J Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Robert A Wise, William Checkley
BACKGROUND: Asthma-COPD Overlap (ACO) represents the confluence of bronchial airway hyper reactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. OBJECTIVE: We aimed to describe the prevalence and risk factors for ACO among adults across six low- and middle-income countries (LMICs). METHODS: We compiled cross-sectional data for 11,923 participants aged 35-92 years from four population-based studies in 12 settings...
October 3, 2018: Journal of Allergy and Clinical Immunology
Haiyan Li, Tangyu Wang, Yiying Tang, Jun Wu, Pengfei Yu, Lei Guo, Jianhua Chen, Yufeng Zhang
BACKGROUND: Orientation field (OF) plays a very significant role in automatic fingerprint recognition systems. Many algorithms have been proposed for the estimation of fingerprints' OF but it is hard to solve the dilemma of correcting spurious ridge structure and avoiding singularity location deviation, especially for poor images. So far, the following drawbacks still need to be solved for OF construction methods for practical application: (1) How to adaptively choose block scales to resolve the contradiction between accuracy and anti-noise, since small scale is beneficial to accuracy but is sensitive to noise, while large scale is more resistant to noise, but the accuracy is deteriorated...
October 1, 2018: Biomedical Engineering Online
Babačić Haris, Goldina Olga, Stahl Kristina, Montagnese Federica, Jurinović Vindi, Schoser Benedikt, Wenninger Stephan
BACKGROUND/AIM: Pulmonary function tests are used for screening respiratory insufficiency in patients with myotonic dystrophy (DM). We analysed the agreement between two different approaches in assessment of abnormal findings of forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), in DM patients. METHODS: We used Cohen's κ- and Bangdiwala's B- statistic to compare the agreement between different cut-off values recommended by experts (ENMC) and the cut-off values based on the reference range (RR)...
September 25, 2018: Journal of Neuromuscular Diseases
Susan M Lee, Rachel Tenney, Arthur W Wallace, Mehrdad Arjomandi
Introduction: Cigarette smoking by surgical patients is associated with increased complications. E-cigarettes have emerged as a potential smoking cessation tool. We sought to determine the feasibility and acceptability of e-cigarettes, compared to nicotine patch, for perioperative smoking cessation in veterans. Methods: Preoperative patients were randomized to either the nicotine patch group ( n  = 10) or the e-cigarette group ( n  = 20). Both groups were given a free 6-week supply in a tapering dose...
2018: PeerJ
Laura Ross, Wendy Stevens, Candice Rabusa, Michelle Wilson, Nava Ferdowsi, Jennifer Walker, Joanne Sahhar, Gene-Siew Ngian, Jane Zochling, Janet Roddy, Kathleen Tymms, Gabor Major, Gemma Strickland, Susanna M Proudman, Mandana Nikpour
OBJECTIVES: The role of the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in the assessment of disease activity in systemic sclerosis (SSc) remains controversial. We sought to evaluate the relationship between clinical features of SSc and raised inflammatory markers and to determine if changes in ESR and CRP reflect changes in other disease features over time. METHODS: One thousand, five hundred and forty-five patients enrolled in the Australian Scleroderma Cohort Study were observed over a mean 3...
July 2018: Clinical and Experimental Rheumatology
Lu Gao, Robert Urman, Joshua Millstein, Kimberly D Siegmund, Louis Dubeau, Carrie V Breton
AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may be involved in airway inflammation. Little is known about how epigenetic changes in AXL may affect lung development during adolescence. We investigated the association between AXL DNA methylation at birth and lung function growth from 10 to 18 years of age in 923 subjects from the Children's Health Study (CHS). DNA methylation from newborn bloodspots was measured at multiple CpG loci across the regulatory regions of AXL using Pyrosequencing...
October 2, 2018: Epigenetics: Official Journal of the DNA Methylation Society
Ewa Rębacz-Maron, Anna Stangret, Iwona Teul
A lower socio-economic status (SES) associates with increased morbidity and mortality. The goal of this study was to define the influence of SES on lung function in indigenous male adolescents (aged 12.8-24.5 years) in Tanzania. The subjects were subdivided into two age groups: <17.5 (n = 189) and ≥ 17.5 years of age (n = 101). They underwent anthropometric and spirometry evaluation. The SES was assessed on the basis of economic family resources and the subjects' nutritional status, and was stratified into three categories: SES-1 (low), SES-2 (average), and SES-3 (high)...
October 2, 2018: Advances in Experimental Medicine and Biology
Kimberly Showalter, Aileen Hoffmann, Gerald Rouleau, David Aaby, Jungwha Lee, Carrie Richardson, Jane Dematte, Rishi Agrawal, Rowland W Chang, Monique Hinchcliff
OBJECTIVE: Forced vital capacity (FVC) and DLCO are used for screening of systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study purpose was to determine the sensitivity, specificity, and negative predictive value (NPV) (proportion of true negative screening tests) of FVC and DLCO thresholds for SSc-ILD on chest high-resolution computed tomography (HRCT) scans. METHODS: Patients fulfilling American College of Rheumatology 2013 SSc criteria with a chest HRCT scan and pulmonary function tests (PFT) were studied...
October 1, 2018: Journal of Rheumatology
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