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Ozkan Doganay, Tahreema Matin, Mitchell Chen, Minsuok Kim, Anthony McIntyre, Daniel R McGowan, Kevin M Bradley, Thomas Povey, Fergus V Gleeson
PURPOSE: To derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary function tests (PFTs). MATERIALS AND METHODS: Twelve COPD subjects (GOLD stages I-IV) participated in this study and underwent HPX-MRI, V/Q-SPECT/CT, high-resolution CT, and PFTs...
December 14, 2018: European Radiology
Justin B Jin, John C Carter, Daniel W Sheehan, David J Birnkrant
OBJECTIVE: To determine the prevalence of discordant cardiopulmonary function among patients with Duchenne muscular dystrophy (DMD) in our clinic. METHODS: Retrospective chart review from 1999 to 2017. INCLUSION CRITERIA: DMD patients age ≥ 18 years, alive, with discordant cardiopulmonary function. No patients received glucocorticoid therapy. Discordant cardiopulmonary function was defined as either: good heart function (EF ≥ 40%) and bad lung function (FVC < 1 L) (Group A); or, bad heart function (EF < 40%) and good lung function (FVC ≥ 1 L) (Group B)...
December 14, 2018: Pediatric Pulmonology
Eun Hye Park, Woo Chang Hwang, Youngjo Lee, Eun Young Lee, Eun Bong Lee, Yeong Wook Song, Jin Kyun Park
OBJECTIVES: To identify factors associated with deterioration of pulmonary function with disproportional decline in diffusing capacity for carbon monoxide (DLCO) relative to forced vital capacity (FVC) in patients with dermatomyositis (DM) and polymyositis (PM). METHODS: This retrospective cohort study included patients with DM and PM, in whom serial pulmonary function tests were available. Changes in FVC and DLCO over time were estimated using a linear mixed-effects model...
December 11, 2018: International Journal of Rheumatic Diseases
Fabien B Vincent, Emily Lin, Joanne Sahhar, Gene-Siew Ngian, Rangi Kandane-Rathnayake, Rachel Mende, Alberta Y Hoi, Eric F Morand, Tali Lang, James Harris
Objectives: Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT), members of the same cytokine superfamily, are linked to the pathogenesis of a number of inflammatory diseases. The aim of this study was to investigate their clinical relevance in systemic sclerosis (SSc). Methods: Serum MIF and DDT were quantified in 105 SSc patients by ELISA and levels compared to healthy controls (HC) (47) and patients with systemic lupus erythematosus (SLE) (184)...
2018: Clinical & Translational Immunology
Alexandra Lenoir, Jean-William Fitting, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Laurent P Nicod
BACKGROUND: Reduced lung function predicts increased mortality, but its prevalence may vary depending on definition considered, use of bronchodilation and applied reference values. We aimed to assess lung function abnormalities in Lausanne, Switzerland, and their association with clinical history. METHODS: In a general population sample, spirometry was performed and bronchodilation applied if the ratio forced expiratory volume in 1 s (FEV1) / forced vital capacity (FVC) or the FVC was below the lower limit of normal (LLN) according to Global Lung Function Initiative 2012 references...
December 13, 2018: Respiratory Research
Hyekyun Rhee, Tanzy Love, Donald Harrington
Background: Sputum neutrophils are associated with severe asthma, poor pulmonary function and high body mass index (BMI) in adult patients. However, little is known about the relationships between blood neutrophils, BMI and asthma severity in pediatric patients. This brief report is to assess the predictive value of blood neutrophils for asthma severity, BMI and pulmonary function in adolescents with asthma. Methods: The study included 166 adolescents with physician diagnosed asthma for at least 1 year...
2018: JSM allergy and asthma
Rodrigo Pereira de Souza, Márcio Vinícius Fagundes Donadio, João Paulo Heinzmann-Filho, Rafael Reimann Baptista, Leonardo Araújo Pinto, Matias Epifanio, Paulo José Cauduro Marostica
OBJECTIVE: To compare muscle thickness and subcutaneous fat in cystic fibrosis (CF) patients and healthy controls using ultrasonography (US), and to correlate US findings with nutritional, clinical and functional variables. METHODS: Patients aged 6 to 18 years old with a diagnosis of CF and healthy controls were included. Participants underwent anthropometric measurements, an ultrasonographic evaluation of muscle thickness and subcutaneous fat in the triceps, quadriceps, and gastrocnemius regions, and skinfold thickness measurements...
October 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Mekuriaw Mesfin Birhan, Yekoye Abebe
Background: Hypertension imposes stresses on many organs like heart and kidney. However, studies that show the effect of hypertension on the lungs are limited. Objective: To assess pulmonary function status of hypertensive patients aged 30-64 years at Zewditu Memorial Hospital, 2017. Methods: Hospital based comparative cross-sectional study was conducted on 61 hypertensive patients (cases) and 61 nonhypertensive clients (controls) aged 30-64 years...
2018: International Journal of Hypertension
Biaoxue Rong, Yufang Liu, Min Li, Tian Fu, Wenlong Gao, Hua Liu
Background: The aim of this study was to disclose the correlation between the serum levels of hypoxia-inducible factor 1 alpha (HIF-1α) and IL-19 and stable COPD. Methods: The serum levels of HIF-1α and IL-19 were tested by ELISA. The relationships between their levels and clinical parameters of stable COPD patients were analyzed by linear regression methods. Results: Patients with stable COPD showed higher serum levels of HIF-1α and IL-19 compared with healthy control group ( P <0...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Carlos Toufen Junior, Roberta R De Santis Santiago, Adriana S Hirota, Alysson Roncally S Carvalho, Susimeire Gomes, Marcelo Brito Passos Amato, Carlos Roberto Ribeiro Carvalho
BACKGROUND: Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that may be related to mechanical ventilation strategy. The aim of this study was to evaluate the association between functional and structural lung impairment, N-terminal-peptide type III procollagen (NT-PCP-III) and driving pressure during protective mechanical ventilation. It was a secondary analysis of data from randomized controlled trial that included patients with moderate/severe ARDS with at least one follow-up visit performed...
December 7, 2018: Annals of Intensive Care
Tamaki Kakuwa, Shinyu Izumi, Keita Sakamoto, Tomoyuki Suzuki, Motoyasu Iikura, Haruhito Sugiyama
Rheumatoid arthritis-related interstitial pneumonia with a usual interstitial pneumonia (RA-UIP) has a poor prognosis and a new treatment strategy is required. The antifibrotic agent nintedanib reduces the annual rate of decline in forced vital capacity (FVC) in idiopathic pulmonary fibrosis (IPF) patients. Recently, the potential efficacy of antifibrotic agents against chronic progressive fibrotic diseases including RA-UIP has been attracting attention. A 74-year-old man diagnosed with IPF on high-resolution computed tomography (HRCT)...
2019: Respiratory Medicine Case Reports
Norimichi Kamikawa, Hironobu Hamada, Kiyokazu Sekikawa, Hikaru Yamamoto, Yoshiya Fujika, Teruki Kajiwara, Fumiya Aizawa, Ippo Otoyama
Dysphagia is the major pathophysiologic mechanism leading to aspiration pneumonia in the elderly. Elderly people with dysphagia who show low levels of the cough peak flow (CPF) are at greater risk for aspiration pneumonia. It has been reported that CPF values were significantly lower in the "soft" versus "hard" mode of a pressure-relieving air mattress in healthy volunteers in a supine position. Parameters such as spinal curvature, however, were not evaluated in detail. In this study, we clarified whether the changes in posture associated with two different firmness levels of a pressure-relieving air mattress were associated with cough production and related factors in the elderly with dysphagia...
2018: PloS One
Margit Tőkés-Füzesi, István Ruzsics, Orsolya Rideg, Péter Kustán, Gábor L Kovács, Tihamér Molnár
Background: Microparticles (MPs) are shedding membrane vesicles released from activated blood and endothelial cells under inflammatory conditions. The role of endothelial MPs (EMPs) in pathophysiology of COPD is relatively well known. However, the release and function of MPs of other cellular origins, eg, platelets, red blood cells and leukocytes, are not clearly evaluated in COPD. Purpose: The aim of this study was to measure EMPs and other cell-derived circulating MPs in stable and exacerbated COPD patients...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Esther Kuperus, Jan C van der Meijden, Stijn L M In 't Groen, Marian A Kroos, Marianne Hoogeveen-Westerveld, Dimitris Rizopoulos, Monica Yasmin Nino Martinez, Michelle E Kruijshaar, Pieter A van Doorn, Nadine A M E van der Beek, Ans T van der Ploeg, W W M Pim Pijnappel
The majority of children and adults with Pompe disease in the population of European descent carry the leaky splicing GAA variant c.-32-13T>G (IVS1) in combination with a fully deleterious GAA variant on the second allele. The phenotypic spectrum of this patient group is exceptionally broad, with symptom onset ranging from early infancy to late adulthood. In addition, the response to enzyme replacement therapy (ERT) varies between patients. The insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) has been suggested to be a modifier of disease onset and/or response to ERT...
2018: PloS One
Heleen Demeyer, David Donaire-Gonzalez, Elena Gimeno-Santos, Maria A Ramon, Jordi de Batlle, Marta Benet, Ignasi Serra, Stefano Guerra, Eva Farrero, Esther Rodriguez, Jaume Ferrer, Jaume Sauleda, Eduard Monso, Joaquim Gea, Robert Rodriguez-Roisin, Alvar Agusti, Josep M Antó, Judith Garcia-Aymerich
INTRODUCTION: COPD progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. METHOD: We studied 114 COPD patients from the PAC-COPD cohort [94% male, mean (SD) 70 (8) years of age, 54 (16) FEV1 % predicted] at baseline and 2...
December 7, 2018: Medicine and Science in Sports and Exercise
Armando Almeida-Junior, Fernando Augusto Lima Marson, Celize Cruz Bresciani Almeida, Maria Ângela Gonçalves Oliveira Ribeiro, Ilma Aparecida Paschoal, Marcos Mello Moreira, José Dirceu Ribeiro
OBJECTIVE: To compare the values of the markers for volumetric capnography and spirometry and their ability to classify children and adolescents with asthma, cystic fibrosis (CF), and healthy controls. METHODS: This was a cross-sectional study that included 103 patients with controlled persistent allergic asthma, 53 with CF and a healthy control group with 40 volunteers (aged 6-15 years), of both sexes. The individuals underwent volumetric capnography and spirometry...
December 6, 2018: Jornal de Pediatria
Ganesh Raghu, Luca Richeldi, Alexandre Jagerschmidt, Valerie Martin, Arun Subramaniam, Marie-Laure Ozoux, Corinne A Esperet, Christina Soubrane
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with 3 to 5 years' survival. Although FVC is used to assess disease progression and treatment response, identifying predictive circulating blood biomarkers could help identify specific biologic pathways for treatment. An international, prospective, noninterventional, case-controlled, 52-week study was therefore conducted to identify a clinical and biomarker baseline profile predictive of longitudinal disease behavior...
December 2018: Chest
Linn T Aalstad, Jon A Hardie, Birgitte Espehaug, Einar Thorsen, Per S Bakke, Tomas M L Eagan, Bente Frisk
BACKGROUND: Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation and is associated with exercise intolerance. However, knowledge of its effect on longitudinal change in the 6-min walk distance (6MWD) in patients with COPD is scarce. We aimed to study whether the IC/TLC ratio predicts longitudinal change in 6MWD in patients with COPD...
December 6, 2018: BMC Pulmonary Medicine
Susan Woolley, Ray Goetz, Pam Factor-Litvak, Jennifer Murphy, Jonathan Hupf, Catherine Lomen-Hoerth, Howard Andrews, Daragh Heitzman, Richard Bedlack, Jonathan Katz, Richard Barohn, Eric Sorenson, Bjorn Oskarsson, Americo Fernandes Filho, Edward Kasarskis, Tahseen Mozaffar, Sharon Nations, Andrea Swenson, Agnes Koczon-Jaremko, Georgia Christodoulou, Hiroshi Mitsumoto
Objective: To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods: We analyzed data from 294 ALS participants, 134 of whom were studied serially. Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes...
2018: Behavioural Neurology
Evangelos Bouros, Vassilios Protogerou, Ourania Castana, Georgios Vasilopoulos
Introduction: Wind instrumentalists require a sophisticated functioning of their respiratory system. Aim: The purpose of this research is to examine the function of the respiratory system of wind instrumentalists. Material and methods: Thirty-two adult professional musicians from two philharmonic bands (Piraeus and Zografou Municipality) participated in the survey. Each participant, after completing a questionnaire given, went through two spirometric tests, one before and one after the rehearsal...
October 2018: Materia Socio-medica
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