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Sungho Hwang, Kyung Jong Lee, Jae Bum Park
OBJECTIVES: This study aimed to examine the effects of chronic exposure to organic solvents on lung function in a shipyard painters. METHODS: Male workers in the shipyard painting department were selected as the organic solvents exposure group. Exposure was classified according to the type of work usually performed, and the cumulative exposure index was obtained using the results of biological monitoring. These were then used to divide the exposure group into low-exposure and high-exposure groups, and the dose-response relationships were examined for decreased lung function...
August 9, 2018: Journal of Occupational and Environmental Medicine
Sairaman Nagarajan, Sabina Ahmad, Markus Quinn, Sabhyata Agrawal, Elena Manilich, Emily Concepcion, Haesoon Lee
BACKGROUND: The aim of this study was to examine if food and/or aeroallergen sensitization was associated with worse asthma, pulmonary function tests (PFT), and laboratory markers. METHODS: At our institution, 386 children with asthma were divided into allergic and nonallergic groups based on allergen-specific immunoglobulin E (IgE) testing classes 1-6 versus 0. Asthma severity and/or control, IgE level, eosinophil counts and/or percentages, forced vital capacity (FVC), forced expiratory volume in the first second of expiration (FEV1), and FEV1/FVC, were compared by using bivariate, regression, and subgroup analyses for children who were highly allergic (≥4 allergens)...
July 1, 2018: Allergy and Asthma Proceedings:
Annabelle Bédard, Kate Northstone, John W Holloway, A John Henderson, Seif O Shaheen
Evidence for a possible protective effect of maternal dietary antioxidant intake during pregnancy on childhood asthma and other atopic outcomes is conflicting, and associations with childhood lung function have been little studied. In the Avon Longitudinal Study of Parents and Children, we analysed associations between maternal intake of fruits, vegetables, vitamins C and E, carotene, zinc, and selenium in pregnancy, and current doctor-diagnosed asthma, atopy, and lung function in 8915 children at 7-9 years...
August 9, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Roneel V Sharan, Udantha R Abeyratne, Vinayak R Swarnkar, Scott Claxton, Craig Hukins, Paul Porter
Spirometry is a commonly used method of measuring lung function. It is useful in the definitive diagnosis of diseases such as asthma and chronic obstructive pulmonary disease (COPD). However, spirometry requires cooperative patients, experienced staff, and repeated testing to ensure the consistency of measurements. There is discomfort associated with spirometry and some patients are not able to complete the test. In this paper, we investigate the possibility of using cough sound analysis for the prediction of spirometry measurements...
August 9, 2018: Physiological Measurement
Ioannis Bakolis, Richard Hooper, Claus Bachert, Bibi Lange, Tari Haahtela, Thomas Keil, Stephanie Hofmaier, Wytske Fokkens, Barbara Rymarczyk, Christer Janson, Peter G J Burney, Vanessa Garcia-Larsen
BACKGROUND: Dietary patterns defined using Principal Component Analysis (PCA) offer an alternative to the analysis of individual foods and nutrients and have been linked with asthma and allergic disease. However, results have not been reproducible in different settings. OBJECTIVE: To identify dietary patterns common to different European countries and examine their associations with asthma and allergic symptoms. METHODS: In sixteen study centres in nine European countries, 3206 individuals aged 15-77 years completed a common, internationally validated, Food Frequency Questionnaire and a respiratory symptoms questionnaire...
August 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Joseph J Cuthbert, Joshua W Kearsley, Syed Kazmi, Anna Kallvikbakka-Bennett, Joan Weston, Julie Davis, Stella Rimmer, Andrew L Clark
BACKGROUND: Differentiating heart failure from chronic obstructive pulmonary disease (COPD) in a patient presenting with breathlessness is difficult but may have implications for outcome. We investigated the prognostic impact of diagnoses of COPD and/or heart failure in consecutive patients presenting to a secondary care clinic with breathlessness. METHODS: In patients with left ventricular systolic dysfunction (LVSD) by visual estimation, N-terminal pro B-type natriuretic peptide (NTproBNP) levels and spirometry were evaluated (N = 4986)...
August 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Stine Hangaard, Thomas Kronborg, Ole K Hejlesen
BACKGROUND: COPD is largely underdiagnosed. Patients with undiagnosed COPD need to be diagnosed to ensure early treatment institution. It is therefore relevant to obtain a more profound understanding of the characteristics of patients with undiagnosed COPD to improve COPD case finding. This study aimed to explore the characteristics of subjects with undiagnosed COPD from the United States National Health and Nutrition Examination Survey (NHANES) dataset (2007-2012) based on post-bronchodilator spirometry...
August 7, 2018: Respiratory Care
Rachel Warner, Porter Knollinger, Gerald Hobbs, Christa Lilly, Daniel Grabo, Alison Wilson
BACKGROUND: Rib fractures (RFx) continue to be a source of morbidity and mortality. A RFx care pathway has been used based on forced vital capacity (FVC). The objective of this study was to test the hypothesis that deterioration of FVC to less than 1 after admission is a marker for high-risk patients and affects outcomes. METHODS: A retrospective study of patients enrolled in an RFx care pathway at a Level 1 trauma center from 2009 to 2014. All patients had an admission FVC greater than 1...
August 2018: Journal of Trauma and Acute Care Surgery
Zhuying Li, Chunyan Tian, Xuehui Wang, Liqin Wang
This retrospective study aimed to investigate the effect and safety of Yiqibushenhuoxue decoction (YQBSHXD) for the treatment of chronic obstructive pulmonary disease (COPD).This study involved 120 cases of patients with COPD. These cases were assigned to an intervention group and a control group equally, 60 subjects each group. Patients in both groups underwent Salmeterol. In addition, the cases in the intervention group also received YQBSHXD. All cases received a total of 12 weeks treatment. The primary outcome of lung function was measured by forced expiratory volume in 1 second (FEV1), and FEV1/forced vital capacity (FVC)...
August 2018: Medicine (Baltimore)
Maria Jose Abadias Medrano, Oriol Yuguero Torres, Ignasi Bardés Robles, Luis Fernando Casas-Méndez, Ferran Barbé, Jordi de Batlle
To describe the characteristics of patients visiting a Hospital Emergency Department (HED) due to chronic obstructive pulmonary disease (COPD) exacerbation (AECOPD) and to evaluate their management.A cross-sectional study of the first 219 patients with AECOPD visiting the HED of the University Hospital Arnau de Vilanova, Lleida, Spain, was performed from January to May 2016. The data collected included the following: main patient characteristics, diagnostic tests, applied treatments, response times, discharge destination, need for hospital admission, and re-admissions and deaths at 90 days...
August 2018: Medicine (Baltimore)
Peter A Frith, Samiha Ashmawi, Srikanth Krishnamurthy, Alev Gurgun, Sashka Hristoskova, Virginia Pilipovic, Anna Marie Hamann, Arthur Backer, Petter Olsson, Konstantinos Kostikas, Dina V Diaz
BACKGROUND AND OBJECTIVE: Combination long-acting β2 -agonist/long-acting muscarinic antagonist (LABA/LAMA) has demonstrated superior clinical outcomes over LABA/inhaled corticosteroid (ICS) in chronic obstructive pulmonary disease (COPD) patients; however, data from blinded randomized controlled trials on direct switching from LABA/ICS to LABA/LAMA are lacking. FLASH (Assessment of switching salmeterol/Fluticasone to indacateroL/glycopyrronium in A Symptomatic COPD patient coHort) investigated if direct switch, without a washout period, from salmeterol/fluticasone (SFC) to indacaterol/glycopyrronium (IND/GLY) in COPD patients improves lung function and is well tolerated...
August 3, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
A A Onuk, D Senen, B Arslan, U Muslu, M Tek, B Karslı
Purpose: Surgical reduction due to breast size is not carried out merely for anesthetic concerns but also for such complaints as breast pain belonging to breast and skeletal system, back pain, neck pain, and intertriginous rashes. This study aims to investigate the effect of bilateral breast reduction surgery on maximum inspiratory pressure (Ppeak) and pulmonary functions. This study aims to investigate the effect of bilateral breast reduction surgery on pulmonary function test. Methods: The study included 50 patients who would undergo bilateral breast reduction...
August 2018: Nigerian Journal of Clinical Practice
Rumi Rabha, Suraj Ghosh, Pratap Kumar Padhy
Wood smoke causes adverse effects on pulmonary function (PF) in women in developing countries. This study compared PF among rural tribal women in northeastern India among 266 wood users and 82 liquefied petroleum gas (LPG) users, all healthy nonsmoking women from April to July, 2014. PF measurements included FVC, FEV1 , FEV1 /FVC, PEF, and FEF25-75% . Information on participants' health status, demographic, and socioeconomic characteristics were collected by questionnaire. Multiple linear regressions were performed to compare PF between the two groups, adjusting for potential confounders...
August 1, 2018: Women & Health
Maribel Casas, Herman T den Dekker, Claudia J Kruithof, Irwin K Reiss, Martine Vrijheid, Jordi Sunyer, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
BACKGROUND: Infant weight gain is associated with lower lung function and a higher risk of childhood asthma. Detailed individual childhood growth patterns might be better predictors of childhood respiratory morbidity than the difference between two weight and height measurements. We assessed the associations of early childhood growth patterns with lung function and asthma at the age of 10 years and whether the child's current body mass index (BMI) influenced any association. METHODS: We derived peak height and weight growth velocity, BMI at adiposity peak, and age at adiposity peak from longitudinally measured weight and height data in the first 3 years of life of 4435 children enrolled in a population-based prospective cohort study...
July 31, 2018: Thorax
Yewande E Odeyemi, O'Dene Lewis, Julius Ngwa, Kristen Dodd, Richard F Gillum, Alem Mehari
PURPOSE: There is presently an ongoing debate on the relative merits of suggested criteria for spirometric airway obstruction. This study tests the null hypothesis that no superiority exists with the use of fixed ratio (FR) of forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) < 0.7 versus less than lower limit predicted (LLN) criteria with or without FEV1 <80% predicted in regards to future mortality. METHODS: In 1988-1994 the Third National Health and Nutrition Examination Survey (NHANES III) measured FEV1 and FVC with mortality follow-up data through December 31, 2011...
July 28, 2018: Journal of the National Medical Association
Xia Wei, Nan Yu, Qi Ding, Jingting Ren, Jiuyun Mi, Lu Bai, Jianying Li, Min Qi, Youmin Guo
BACKGROUND: Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to identify the factors associated with carbon dioxide retention. METHODS: This was a retrospective study of consecutive patients with COPD (meeting the Global Initiative for Chronic Obstructive Lung Disease diagnostic criteria) hospitalized at The Ninth Hospital of Xi'an Affiliated Hospital of Xi'an Jiaotong University between October 2014 and September 2017...
July 31, 2018: BMC Pulmonary Medicine
G Liyanage, B D Jayamanne
Background: Reference values of lung functions vary with age, height, ethnicity and sex of the reference population. Global Function Initiative 2012 compared reference equations for Sri Lankan children with those of South Indian and South East Asian equations. Sri Lanka has a multi-ethnic society comprising of Sinhalese, Tamils, Moors and other ethnic minorities. Applicability of existing Sri Lankan equations to children from different ethnic groups in the country has not been adequately verified...
June 30, 2018: Ceylon Medical Journal
David Langton, Alvin Ing, David Fielding, Wei Wang, Virginia Plummer, Francis Thien
BACKGROUND AND OBJECTIVE: A characteristic feature of asthma is hypertrophied airway smooth muscle, responsible for bronchoconstriction. This is the target of bronchial thermoplasty (BT). It is known that with increasing time and severity some patients develop remodelled airways with fixed airflow obstruction. The question arises whether these patients will still respond to BT. METHODS: Forty-nine consecutive severe asthmatic patients were prospectively evaluated at baseline and then 6 months after BT...
July 31, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Catherine H Miele, Matthew R Grigsby, Trishul Siddharthan, Robert H Gilman, J Jaime Miranda, Antonio Bernabe-Ortiz, Robert A Wise, William Checkley
BACKGROUND: Chronic lung disease is a leading contributor to the global disease burden; however, beyond tobacco smoke, we do not fully understand what risk factors contribute to lung function decline in low-income and middle-income countries. METHODS: We collected sociodemographic and clinical data in a randomly selected, age-stratified, sex-stratified and site-stratified population-based sample of 3048 adults aged ≥35 years from four resource-poor settings in Peru...
July 30, 2018: Thorax
Marta Maskey-Warzęchowska, Katarzyna Górska, Patrycja Nejman-Gryz, Magdalena Paplińska-Goryca, Tomasz Grzela, Alicja Krejner, Katarzyna Grzela, Rafał Krenke
Introduction Data on the measurement of matrix metalloproteinase 9 (MMP-9) in exhaled breath condensate (EBC) from patients with COPD are scarce and inconsistent. Objectives to 1/ assess the feasibility and agreement between enzyme-linked immunosorbent assay (ELISA) and immunoenzymatic assay (IEA) in MMP-9 measurement in EBC, and 2/ assess the relationships between EBC total and active MMP-9 and clinical and functional COPD characteristics. Patients and methods Total (ELISA and IEA) and active (IEA) MMP-9 were assessed in EBC from 70 patients with stable COPD and 21 controls and correlated with pulmonary function and COPD symptom level...
July 27, 2018: Polish Archives of Internal Medicine
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