Martina Milella, Monica Rutigliano, Francesco Lasorsa, Matteo Ferro, Roberto Bianchi, Giuseppe Fallara, Felice Crocetto, Savio Domenico Pandolfo, Biagio Barone, Antonio d'Amati, Marco Spilotros, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Mucins are a family of high-molecular-weight glycoproteins. MUC1 is widely studied for its role in distinct types of cancers. In many human epithelial malignancies, MUC1 is frequently overexpressed, and its intracellular activities are crucial for cell biology. MUC1 overexpression can enhance cancer cell proliferation by modulating cell metabolism. When epithelial cells lose their tight connections, due to the loss of polarity, the mucins become dispersed on both sides of the epithelial membrane, leading to an abnormal mucin interactome with the membrane...
March 7, 2024: Biomolecules