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Hashimoto’s thyroiditis

Ahmet Kırgız, Kübra Şerefoğlu Çabuk, Mikail Yetmis, Kürşat Atalay
BACKGROUND: Hashimoto's thyroiditis (HT) is an autoimmune endocrine disorder that results from a dysregulation of the immune system leading to an immune attack on the thyroid gland. It has potential effects on different organs and tissues. OBJECTIVES: The aim of the study was to investigate the effect of HT on corneal biomechanical properties using the ocular response analyzer (ORA). MATERIAL AND METHODS: A total of 48 patients with HT and 49 healthy subjects were enrolled in the study...
October 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Line Riis Jølving, Jan Nielsen, Ulrik Schiøler Kesmodel, Rasmus Gaardskær Nielsen, Bente Mertz Nørgård, Signe Sparre Beck-Nielsen
Objective: Maternal thyroid disease (TD) during pregnancy is associated with adverse birth outcomes, but little is known on its long-term outcomes. We aimed to examine if children born to mothers with TD have increased disease risk during childhood and adolescence. Patients and methods: A register-based cohort study was conducted on all live born children in Denmark from 1989 to 2013, including the association between maternal TD during pregnancy and somatic and psychiatric diseases in the children...
2018: Clinical Epidemiology
Maria Giannakou, Katerina Saltiki, Emily Mantzou, Eleni Loukari, Georgios Philippou, Konstantinos Terzidis, Charalampos Stavrianos, Miltiades Kyprianou, Theodora Psaltopoulou, Kalliopi Karatzi, Maria Alevizaki
Objective: Increased oxidative stress has been described in patients with Hashimoto’s thyroiditis (HT). The aim of the present study was to investigate whether high oxidative stress is further influenced by obesity and dietary habits in euthyroid women with HT. Methods: Two hundred eighteen consecutive euthyroid women with HT were studied and separated in two groups; 102 with thyroxine replacement and 114 without. For the evaluation of oxidative stress, total lipid peroxide levels in serum (TOS) were measured and recoded as ‘high TOS’ vs ‘medium/low TOS’...
September 1, 2018: Endocrine Connections
Hye Jin Baek, Dong Wook Kim, Yoo Jin Lee, Hye Shin Ahn, Ji Hwa Ryu
This study aimed to compare diagnostic accuracy of real-time and static ultrasonography (US) for differentiating diffuse thyroid disease (DTD) from normal thyroid parenchyma (NTP). At 4 participating institutions, 203 patients underwent real-time thyroid US before thyroid surgery. For static US, the same radiologists retrospectively evaluated US findings on a picture archive and communication system after 4 weeks. In real-time and static US diagnoses, US category included no DTD, indeterminate, suspicious for DTD, and DTD...
October 8, 2018: Ultrasound Quarterly
Tatsuya Kusudo, Michihiro Hashimoto, Naoya Kataoka, Yongxue Li, Aya Nozaki, Hitoshi Yamashita
Brown adipocytes play a critical role for adaptive thermogenesis to regulate body temperature in cold or to circumvent diet-induced obesity. In the present study, we investigated the role of cellular repressor of E1A-stimulated genes 1 (CREG1) on brown adipogenesis and uncoupling protein 1 (UCP1) expression by using in vitro culture models. In murine mesenchymal stem cell line C3H10T1/2, Creg1 mRNA expression significantly increased in a time-dependent manner along with Ucp1 mRNA induction in brown adipogenesis...
October 6, 2018: Journal of Biochemistry
Camilla Virili, Poupak Fallahi, Alessandro Antonelli, Salvatore Benvenga, Marco Centanni
About two third of the human microbial commensal community, namely the gut microbiota, is hosted by the gastrointestinal tract which represents the largest interface of the organism to the external environment. This microbial community co-evolved in a symbiotic relationship with the human beings. Growing evidence support the notion that the microbiota plays a significant role in maintaining nutritional, metabolic and immunologic homeostasis in the host. Microbiota, beside the expected role in maintaining gastrointestinal homeostasis also exerts metabolic functions in nutrients digestion and absorption, detoxification and vitamins' synthesis...
October 8, 2018: Reviews in Endocrine & Metabolic Disorders
Tanja Diana, Paul D Olivo, George J Kahaly
Autoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) may mimic or block the action of TSH or be functionally neutral. Measurement of anti-TSHR-Ab can be done either via competitive-binding immunoassays or with functional cell-based bioassays. Antibody-binding assays do not assess anti-TSHR-Ab functionality, but rather measure the concentration of total anti-TSHR binding activity. In contrast, functional cell-based bioassays indicate whether anti-TSHR-Ab have stimulatory or blocking activity...
October 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
L Brčić, A Barić, S Gračan, M Brekalo, D Kaličanin, I Gunjača, V Torlak Lovrić, S Tokić, M Radman, V Škrabić, A Miljković, I Kolčić, M Štefanić, L Glavaš-Obrovac, D Lessel, O Polašek, T Zemunik, M Barbalić, A Punda, V Boraska Perica
PURPOSE: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the first GWAS followed by replication in a total of 1443 individuals from Croatia. METHODS: We performed association analysis in a discovery cohort comprising 405 cases and 433 controls...
October 3, 2018: Journal of Endocrinological Investigation
S Zhang, X H Jiang
Objective: To explore the clinical features of papillary thyroid carcinoma(PTC) patients associated with lateral lymph node metastasis(LLNM) in different ages. Method: One hundred and sixtyfive PTC patients associated with LLNM were included in the study and divided into three groups(22-<30y,30-<45y and 45-65y). The gender, the number and the ratio of neck lymph node metastasis, maximum tumor diameter, multifocality, preoperative serum thyroid stimulating hormone(TSH), the capsular invasion, extrathyroidal extension and other clinical features in different ages were analyzed...
September 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Natascha Roehlen, Claudia Doering, Martin-Leo Hansmann, Frank Gruenwald, Christian Vorlaender, Wolf Otto Bechstein, Katharina Holzer, Klaus Badenhoop, Marissa Penna-Martinez
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects...
2018: Frontiers in Endocrinology
Muge Bilge, Aylia Yesilova, Mine Adas, Aysen Helvaci
BACKGROUND: Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reported to be increased in various inflammation-related diseases, but their clinical significance in HT remains unclear. OBJECTIVES: The aim of this study was to investigate the relationship between thyroid autommunity and NLR and PLR as markers of systemic inflammation in HT. METHODS: In this study, we evaluated 145 women with HT and 60 age-matched healthy controls...
September 28, 2018: Experimental and Clinical Endocrinology & Diabetes
Dean Kaličanin, Luka Brčić, Ana Barić, Sanja Zlodre, Maja Barbalić, Vesela Torlak Lovrić, Ante Punda, Vesna Boraska Perica
OBJECTIVE: We have comprehensively evaluated an immunologic response to food antigens, mediated by immunoglobulin G (IgG) antibodies, on clinical aspects of Hashimoto's thyroiditis (HT). METHODS: IgG antibodies to 125 food antigens were measured in serum samples of 74 HT patients and 245 controls using microarray-based enzyme-linked immunosorbent assay (ELISA) test. We analyzed differences in IgG levels between two groups and evaluated correlations between food-specific IgG levels and HT-related clinical phenotypes (thyroid hormones/antibodies, symptoms of hypothyroidism, measures of body size and blood pressure) and food consumption in HT patients...
September 28, 2018: Journal of the American College of Nutrition
Seher Erdoğan, Sevinç Kalın
Hashimoto encephalopathy (HE) is a steroid-responsive, acute or subacute encephalopathy, characterised by autoimmune thyroiditis associated with elevated antithyroid antibody titres. An 11-year-old girl was admitted to the Department of Paediatrics with generalised tonic-clonic seizures, left facial paralysis and right hemiparesis. Ceftriaxone and acyclovir were applied, and methyl prednisolone 2 mg kg-1 day-1 was administered orally. The hemiparesis improved on the 3rd day of treatment, but the facial paralysis persisted into the 15th day...
September 2018: Turkish Journal of Anaesthesiology and Reanimation
Jussi O T Sipilä, Eero Rissanen, Jaana Korpela, Markku Päivärinta
Being treatable, steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto's encephalopathy, should be distinguished from untreatable conditions. Our patient was a previously healthy 89-year-old man, who presented with cognitive and balance deterioration over several months. His cerebrospinal fluid (CSF) examination was positive for protein 14-3-3 but no other test suggested Creutzfeldt-Jacob disease. His condition improved markedly, although not fully, with intravenous corticosteroids...
October 2018: Oxford Medical Case Reports
Piotr Kmieć, Ilona Minkiewicz, Krzysztof Sworczak, Michał A Żmijewski, Konrad Kowalski
INTRODUCTION: In the context of pleiotropic vitamin D effects its role has also been investigated in thyroid pathology, in particular autoimmune thyroid diseases (AITD). However, available data concerning vitamin D status among Polish adult population are inconclusive. AIM: In the study we investigated vitamin D status and adequacy of supplementation, as well as sunlight exposure during summer months among adult patients with thyroid diseases. MATERIALS AND METHODS: Adults with diagnosed or suspected thyroid disease were recruited almost entirely in an ambulatory setting from June through September in Northern Poland...
September 27, 2018: Endokrynologia Polska
Jan Krátký, Jana Ježková, Mikuláš Kosák, Hana Vítková, Jana Bartáková, Miloš Mráz, Jindřich Lukáš, Zdenka Límanová, Jan Jiskra
The relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included. Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs...
2018: International Journal of Endocrinology
Qian Li, Bin Wang, Kaida Mu, Jin-An Zhang
Autoimmune thyroid disease (AITD) is one of the most common organ-specific autoimmune disorders. It mainly manifests as Hashimoto's thyroiditis (HT) and Graves' disease (GD). HT is characteristic of hypothyroidism resulting from the destruction of the thyroid while GD is characteristic of hyperthyroidism due to excessive production of thyroid hormone induced by thyrotropin receptor-specific stimulatory autoantibodies. T lymphocytes and their secretory cytokines play indispensable roles in modulating immune responses, but their roles are often complex and full of interactions among distinct components of the immune system...
September 24, 2018: Journal of Cellular Physiology
Miguel Paja, Jose L Del Cura
No abstract text is available yet for this article.
September 20, 2018: Endocrinología, Diabetes y Nutrición
Joanna Bladowska, Marta Waliszewska-Prosół, Maria Ejma, Marek Sąsiadek
Hashimoto's thyroiditis (HT) is the most common autoimmune disease in humans usually associated with subsequent hypothyroidism. The purpose of the study was to assess metabolic alterations within the normal appearing brain in subjects with HT using MR spectroscopy (MRS) and to correlate MRS measurements with hormonal concentrations. Fifty-five HT patients (mean age 43.5 yrs) and 30 healthy controls (mean age 42.5 yrs) were examined with the use of a 1.5 T MR scanner. There were no signs of central nervous system involvement in the studied group...
September 21, 2018: Metabolic Brain Disease
Weiheng Wen, Peili Wu, Jitong Li, He Wang, Jia Sun, Hong Chen
BACKGROUND: The American Joint Committee on Cancer has recently revised the tumor-node-metastasis (TNM) staging system on thyroid cancer, which illustrated that the cut-off age for predicting mortality has elevated from 45 to 55 years old. We aimed to investigate the inflammation index based on hematological parameters to predict the clinical characteristics of elderly papillary thyroid cancer (PTC) patients with an inferior prognosis. METHODS: We retrospectively analyzed 558 patients newly diagnosed with PTC from January 2013 to December 2017, and 82 out of the 558 patients were over 55 years old...
September 21, 2018: Journal of Translational Medicine
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