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Hashimoto’s thyroiditis

Shinichi Suzuki, Tetiana I Bogdanova, Vladimir A Saenko, Yuko Hashimoto, Masahiro Ito, Manabu Iwadate, Tatiana Rogounovitch, Mykola D Tronko, Shunichi Yamashita
Thyroid ultrasound screening of young residents in Fukushima prefecture of Japan demonstrated high detection rate of papillary thyroid carcinoma (PTC). Detailed morphological analysis of these tumors was not presented to date. This study sets out to evaluate changes in histopathological and invasive characteristics of Fukushima PTC with time after the nuclear accident of March 2011 in all available cases and in different age subgroups. Histological specimens of 115 PTCs from patients aged ≤ 18 years at the time of Fukushima Dai-ichi Nuclear Power Plant accident operated at Fukushima Medical University during 2012-2016 were reviewed...
December 11, 2018: Cancer Science
R Zeng, M Zhao, H Niu, K-X Yang, T Shou, G-Q Zhang, X-M Yan
OBJECTIVE: We investigated the relationship between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) in children and adolescents. PATIENTS AND METHODS: We carried out a retrospective study of thyroidectomies performed from 2004 to 2017 at The First People's Hospital and the Tumor Hospital of Yunnan Province (Kunming, China). The occurrence and features of PTC and benign thyroid disease (BTD) in children and adolescents (age ≤ 20 years) were compared...
November 2018: European Review for Medical and Pharmacological Sciences
X Jia, T Zhai, B Wang, J Zhang, F Zhang
PURPOSE: Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune disorders, predominantly including Graves' disease (GD), and Hashimoto's thyroiditis (HT). This study aimed to investigate whether single-nucleotide polymorphisms (SNPs) in MAGI2 and MAGI3 gene contributed to the etiology of AITDs. METHODS: We conducted a case-control study including 1001 patients with AITDs (625 GD, 376 HT) and 846 healthy controls. Subgroup analyses in GD and HT were also performed...
December 8, 2018: Journal of Endocrinological Investigation
Kornelia Karwowska, Joanna Wernik, Abdulhakeem Abdulgater
The patient was diagnosed with chronic hepatitis B at 19 years old. Biochemical, serological and histopathological diagnostic processes were followed by pegylated interferon treatment. After 24 weeks of therapy treatment was discontinued due to pathological thyroid hormones values. The patient was diagnosed with Hashimoto's thyroiditis and levothyroxine therapy initiated. Over the following two years, the patient was not under hepatology specialist care. She was admitted to the Clinic due to a high aminotransferase level and concomitant pruritus in the 32nd week of her first pregnancy...
November 28, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Qinghai Peng, Chengcheng Niu, Meixiang Zhang, Qiang Peng, Sijie Chen
Our objective was to provide the various sonographic characteristics of papillary thyroid carcinomas for Hashimoto's thyroiditis (HT) patients, including conventional ultrasound (US), acoustic radiation force impulse Virtual Touch imaging and quantification (ARFI-VTIQ) and contrast-enhanced ultrasound (CEUS). Sixty-nine HT patients with 85 thyroid nodules (TNs) (49 malignant and 36 benign) were enrolled in this study. We evaluated the size, shape, margin, echogenicity, presence of halo, calcification, vascularity and ARFI-VTIQ and CEUS parameters for each nodule and compared the findings with the reference standards of histopathological and/or cytologic results...
December 8, 2018: Ultrasound in Medicine & Biology
Shu-Hui Wang, Jui Wang, Yu-Sheng Lin, Tao-Hsin Tung, Ching-Chi Chi
BACKGROUND: The association between psoriasis and thyroid diseases was unclear. OBJECTIVE: To examine the risk of thyroid diseases in psoriasis patients. METHODS: We used Taiwan's National Health Insurance Research Database to conduct a nationwide cohort study. We examined the hazard ratio (HR) and 95% confidence interval (CI) for incident thyroid diseases in relation to psoriasis and psoriatic arthritis. RESULTS: We identified 13,266 patients with psoriatic arthritis (psoriasis arthritis group), 149,576 with psoriasis alone (psoriasis group), and 162,842 nonpsoriatic controls...
December 5, 2018: Journal of the American Academy of Dermatology
Di Wu, Rui Guo, Huiling Guo, Yushu Li, Haixia Guan, Zhongyan Shan
BACKGROUND: Resistance to thyroid hormone beta (RTHβ) results in symptoms of both increased and decreased thyroid hormone action. The effect of thyroid hormone changes in different types of autoimmune thyroid disease (AITD) in RTHβ is dynamic. CASE PRESENTATION: A 25-year-old Asian female had a RTHβ Y321C mutation with Hashimoto's thyroiditis and type 2 diabetes mellitus. She was followed-up through gestation and two years postpartum, revealing development of postpartum thyroiditis (PPT) with characteristic wide fluctuations in serum thyrotropin levels, and of spontaneous recovery from an episode of transient hypothyroidism...
December 3, 2018: BMC Pregnancy and Childbirth
Mariella Valenzise, Federica Porcaro, Giuseppina Zirilli, Filippo De Luca, Maurizio Cinquegrani, Tommaso Aversa
Clinical picture of Hashimoto's thyroiditis (HT) may significantly vary in pediatric age, ranging from euthyroidism to subclinical hypothyroidism or hyperthyroidism; only rarely HT presentation may be characterized by a severe hypothyroidism also in pediatric age. Here we describe a 3-year-old Caucasian girl who was admitted to our Clinic due to pericardial effusion, muscle weakness and weight gain. At clinical examination, she presented with bradycardia, pale and round face, pseudohypertrophy of calf muscles and no pitting edema of the limbs...
December 5, 2018: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Shinje Moon, Hye Soo Chung, Jae Myung Yu, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Young Joo Park
BACKGROUND: Epidemiological studies have suggested an association between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) development. Other studies, however, have reported a protective role of HT against PTC progression. Through this updated meta-analysis, we aimed to clarify the effects of HT on the progression of PTC. METHODS: We searched citation databases, including PubMed and Embase, for relevant studies from inception to September 2017. From these studies, we calculated the pooled odds ratios (ORs) of clinicopathologic features and the relative risk (RR) of PTC recurrence with 95% confidence intervals (CIs) using the Mantel-Haenszel method...
December 2018: Endocrinology and Metabolism
Serhat Emeksiz, Nurettin Onur Kutlu, Nuri Alaçakır, Hüseyin Çaksen
Emeksiz S, Kutlu NO, Alaçakır N, Çaksen H. A case of steroid-resistance Hashimoto's encephalopathy presenting with sensorimotor polyneuropathy. Turk J Pediatr 2018; 60: 310-314. Hashimoto`s encephalopathy (HE) is a rare, auto-immune disease characterized by symptoms of acute or subacute encephalopathy associated with increased anti-thyroid antibody levels. The course of most HE cases is relapsing and remitting, which is similar to that of vasculitis and stroke. Steroids are the first line treatment in HE...
2018: Turkish Journal of Pediatrics
Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Claudia Caruso, Salvatore Benvenga, Poupak Fallahi, Alessandro Antonelli
Patients affected by autoimmune thyroiditis reached positive effects on indices of thyroid autoimmunity and/or thyroidal function, after following a treatment with selenomethionine (Se) alone, or Se in combination with Myo-inositol (Myo-Ins). Our purpose was to investigate if Myo-Ins alone, or a combination of Se + Myo-Ins, is effective in protecting thyroid cells from the effects given by cytokines, or hydrogen peroxide (H2 O2 ). We assessed the interferon (IFN)-γ-inducible protein 10 (IP-10/CXCL10) secretion by stimulating primary thyrocytes (obtained from Hashimoto's thyroiditis or from control patients) with cytokines in presence/absence of H2 O2...
December 4, 2018: Reviews in Endocrine & Metabolic Disorders
Ozge Caglar, Akin Cayir
BACKGROUND: Thyroid cancer is a common endocrine cancer. Great progress has been made in resolving its molecular mechanisms in recent years. The molecular changes observed in thyroid cancer can be used as biomarkers for diagnostic, prognostic and therapeutic purposes. MicroRNAs (miRNAs) are important components in biological and metabolic pathways, such as developmental stages, signal transduction, cell maintenance, and differentiation. Hence, their malfunctioning can expose humans to malignancies...
December 2, 2018: Journal of Cellular Biochemistry
Akira Ohtsuru, Sanae Midorikawa, Tetsuya Ohira, Satoru Suzuki, Hideto Takahashi, Michio Murakami, Hiroki Shimura, Takashi Matsuzuka, Seiji Yasumura, Shin-Ichi Suzuki, Susumu Yokoya, Yuko Hashimoto, Akira Sakai, Hitoshi Ohto, Shunichi Yamashita, Koichi Tanigawa, Kenji Kamiya
Importance: Ultrasonographic (US) screening for thyroid cancer was performed in the Fukushima Health Management Survey after the 2011 Fukushima Daiichi nuclear power station accident. Clinical characteristics of thyroid cancers screened by US among children and young adults during the first 5 years after the accident were analyzed. Objectives: To evaluate the number of detected thyroid cancers by age group within 5 years of the Fukushima Daiichi nuclear power station accident and to compare the basic clinical characteristics and demographic patterns in first- and second-round examinations...
November 29, 2018: JAMA Otolaryngology—Head & Neck Surgery
Olgica Mihaljevic, Snezana Zivancevic-Simonovic, Olivera Milosevic-Djordjevic, Predrag Djurdjevic, Danijela Jovanovic, Zeljko Todorovic, Darko Grujicic, Marina Radovic-Jakovljevic, Jovana Tubic, Aleksandra Markovic, Milan Paunovic, Marijana Stanojevic-Pirkovic, Slavica Markovic
As apoptosis and genome instability in children with autoimmune diseases (AIDs) are insufficiently investigated, we aimed to analyse them in peripheral blood lymphocytes (PBLs) of children and adolescents with Hashimoto's thyroiditis (HT), Graves' disease (GD) and type 1 diabetes mellitus (T1DM), including possible factors that could affect their occurrence. The study population included 24 patients and 19 healthy controls. Apoptotic cells were detected using an Annexin V-FITC/7-AAD kit. Genome instability was measured as micronuclei (MNs) frequency using the cytokinesis-block MN assay...
November 27, 2018: Mutagenesis
Shan Jin, Wuyuntu Bao, Yun-Tian Yang, Tala Bai, Yinbao Bai
This study aimed to establish a model for predicting lateral neck lymph node metastasis in patients with papillary thyroid carcinoma. A total of 106 patients with papillary thyroid carcinoma undergoing initial treatment of neck lymph node dissection (including central and lateral neck lymph nodes) at the thyroid surgery department were enrolled from January 2009 to April 2017. Logistic regression analysis was used to screen the factors influencing lateral neck lymph node metastasis and develop a prediction model...
November 26, 2018: Scientific Reports
Jun Xu, Xiang-Yun Zhu, Hui Sun, Xiao-Qin Xu, Song-Ao Xu, Yuan Suo, Li-Jun Cao, Qiang Zhou, Hui-Jie Yu, Wei-Zhong Cao
BACKGROUND: Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT. METHODS: We recruited 194 patients with HT and 200 healthy volunteers. Levels of serum 25-hydroxyvitamin D (25(OH)D) were measured using a competitive protein-binding assay. Cognitive funtion was assessed using Montreal Cognitive Assessment score (MoCA)...
November 26, 2018: BMC Endocrine Disorders
Takayuki Kunisato, Mikio Watanabe, Naoya Inoue, Azusa Okada, Takashi Nanba, Wataru Kobayashi, Yuka Inoue, Yuka Katsumata, Naoki Omori, Takayuki Nobuhara, Kazuya Takemura, Yoh Hidaka, Yoshinori Iwatani
The prognosis of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD. However, the association between gene polymorphisms in Th17-related genes and the prognosis of AITD was not clarified. To clarify this association, we genotyped 12 polymorphisms in 11 Th17-related genes (IL1Ra, IL6R, IL17R, IL21R, IL23R, CCR6, SOCS3, RORC, IL17A, IL17F and IL21) in 142 HD patients including 58 patients with severe HD and 48 patients with mild HD, 170 patients with GD including 81 patients with intractable GD and 49 patients with GD in remission, and 84 healthy volunteers...
November 24, 2018: Autoimmunity
Jenna N Bates, Taylor P Kohn, Alexander W Pastuszak
INTRODUCTION: Sexual dysfunction affects many people, with 33‒60% of women reporting sexual dysfunction and 8‒52% of men with erectile dysfunction or premature ejaculation. In an effort to determine the constellation of factors responsible for sexual dysfunction, the effect of thyroid hormone derangements has been of recent interest. AIM: To investigate the associations between thyroid hormones and sexual dysfunction in women and men. METHODS: Literature was reviewed to examine the effects of hypo- and hyperthyroidism on sexual function...
November 17, 2018: Sexual Medicine Reviews
H Graefe, E Biermann, M Mandapathil, M Weber, M Merkel, J E Meyer
Diseases of the thyroid gland are frequent incidental findings during ultrasound examination of the neck. They affect nearly one third of the normal population. Treatment is not always indicated; however, laboratory diagnostic measures must be initiated to specify the disease. The primary indications for consulting a thyroid specialist are thyroid nodules, goiters, autonomy of the thyroid gland, autoimmune diseases, Graves' disease, and Hashimoto thyroiditis. The aim of this review is to provide an overview of the most important thyroid diseases and their treatment options...
November 19, 2018: HNO
Roberto Vita, Antonio Ieni, Giovanni Tuccari, Salvatore Benvenga
Although the incidence of some malignancy has decreased over the recent years, this is not the case of papillary thyroid microcarcinoma (PTMC), whose incidence has increased worldwide. Most PTMC are found incidentally after histological examination of specimens from surgery for benign thyroid disease. Hashimoto's thyroiditis, whose incidence has also increased, coexists in about one in three PTMC patients. Three different mechanisms have been proposed to clarify the association between chronic lymphocytic thyroiditis and PTMC, namely tumor development/growth by: (i) TSH stimulation, (ii) expression of certain proto-oncogenes, (iii) chemokines and other molecules produced by the lymphocytic infiltrate...
November 20, 2018: Reviews in Endocrine & Metabolic Disorders
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