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Nodular thyroid disease

Belinda Hii, Dominic Maher, Meei Yeung, Eldho Paul, Jonathan W Serpell, James C Lee
BACKGROUND: Since the mid-1800s, thyroidectomy has transformed from a procedure associated with high to near-zero mortality. Nonetheless, surgeons must continue to strive to improve patient care. Using historical records and contemporary data, this study compares the practice and outcomes of thyroid surgery at a tertiary institution during two periods, 50 years apart. METHODS: 'The Alfred Hospital Clinical Reports' recorded all cases of surgically managed thyroid disease from 1946 to 1959...
December 7, 2018: World Journal of Surgery
Nadia Sawicka-Gutaj, Paulina Ziółkowska, Jerzy Sowiński, Agata Czarnywojtek, Katarzyna Milczarczyk, Paweł Gut, Marek Ruchała
INTRODUCTION Goiter recurrence occurs in a substantial number of patients after thyroid resection. OBJECTIVES We aimed to investigate the prevalence and risk factors of recurrent goiters, influence of goiter recurrence on patient quality of life (QoL) and the efficacy of therapy with radioactive iodine (RAI). PATIENTS AND METHODS This was a case-control study. All thyroidectomized patients admitted within the past year to the outpatient department were included in the study and their medical records were analyzed...
December 5, 2018: Polish Archives of Internal Medicine
Pawel Domoslawski, Bartosz Pula, Mateusz Olbromski, Beata Wojtczak, Tadeusz Lukienczuk, Marzenna Podhorska-Okolow, Piotr Dziegiel
BACKGROUND/AIM: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients. RESULTS: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients...
December 2018: Anticancer Research
Mandeep Singla, Abhinav Gupta
No abstract text is available yet for this article.
November 14, 2018: American Journal of Medicine
Xiaoxu Zhang, Miao Guo, Jing Yang, Yuxiao Zheng, Yanjie Xiao, Wei Liu, Fu Ren
Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. GARP has been recently observed in only a few solid tumors including breast, colon, lung cancers, and melanoma. However, its function in cancers remains unknown. Here, we investigated the expression of GARP in human papillary thyroid carcinoma (PTC) and its prognostic significance...
November 16, 2018: Endocrine Pathology
Sema Ciftci Dogansen, Artur Salmaslioglu, Gulsah Yenidunya Yalin, Seher Tanrikulu, Sema Yarman
PURPOSE: To investigate the nodular thyroid disease (NTD) and the natural course of thyroid nodules in patients with acromegaly. METHODS: 138 patients with acromegaly (73 F/65 M), whose initial thyroid ultrasonography performed in our university hospital, were included in this study. The frequencies of NTD, papillary thyroid cancer (PTC) and associated factors on nodule formation were investigated at initial assessment. Patients who had NTD continued to follow-up (n = 56) were re-evaluated with a ultrasonography performed after a mean 7-years follow-up period...
November 14, 2018: Pituitary
Crystal D C Kamilaris, Fabio Rueda Faucz, Antonis Voutetakis, Constantine A Stratakis
Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and lentiginosis syndrome, caused in most patients by defects in the PRKAR1A gene, which encodes the regulatory subunit type 1α of protein kinase A. Inactivating defects of PRKAR1A lead to aberrant cyclic-AMP-protein kinase A signaling. Patients may develop multiple skin abnormalities and a variety of endocrine and non-endocrine tumors. Endocrine manifestations include primary pigmented nodular adrenocortical disease, that may cause Cushing syndrome, growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperplasia which can result in acromegaly, as well as gonadal and thyroid tumors...
November 14, 2018: Experimental and Clinical Endocrinology & Diabetes
Luigi Vimercati, Luigi De Maria, Francesca Mansi, Antonio Caputi, Giovanni Maria Ferri, Vito Luisi, Piero Lovreglio, Enza Sabrina Silvana Cannone, Pietro Lorusso, Maria Franca Gatti, Chiara Rosaria Stella Massagli, Vincenzo Triggiani
BACKGROUND: Thyroid diseases occur more frequently in people exposed to ionising radiation, but the relationship between occupational exposure to ionising radiation and thyroid pathologies still remains unclear. OBJECTIVE: To evaluate the prevalence of thyroid diseases in healthcare workers exposed to low-level ionising radiation compared with a control group working at the University Hospital of Bari, Southern Italy, and living in the same geographical area, characterised by mild iodine deficiency...
November 2, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Chang-Fu Kuo, I-Jun Chou, Matthew J Grainge, Shue-Fen Luo, Lai-Chu See, Kuang-Hui Yu, Weiya Zhang, Michael Doherty, Ana M Valdes
Purpose: To estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks. Patients and methods: This population-based study used the Taiwan National Health Insurance database to reconstruct family structure and identify people with T1D and other chronic diseases between 1999 and 2015. Relative risks (RRs) for T1D and other chronic diseases and heritability of T1D were estimated...
2018: Clinical Epidemiology
Georgios Boutzios, Gerasimos Tsourouflis, Zoe Garoufalia, Krystallenia Alexandraki, Grigorios Kouraklis
INTRODUCTION: Nodular goiter is the most common disorder of the thyroid gland. Less than total thyroidectomy procedures are considered the gold standard in the surgical management of nodular thyroid disease despite its propensity for recurrence. The aim of the study was to assess long-term sequelae of the less than total thyroidectomy procedures. MATERIAL AND METHODS: In this single-center retrospective study, records of 154 patients that underwent less than total thyroidectomy, for nodular disease and/or hyperthyroidism between 1998 and 2013, were reviewed...
October 9, 2018: Endocrine
M M Uygur, T Yoldemir, D G Yavuz
The interpretation of thyroid function tests should be cautiously made during the perimenopause and postmenopause period bearing in mind that physiologic changes do exist in this group of women in terms of secretion and metabolism of thyrotropin and thyroid hormones. Moreover the incidence of thyroid disorders increases in postmenopausal and elderly women. There is no consensus for screening postmenopausal women even though there is well-known evidence about the effect of thyroid status on cognitive function, cardiovascular risk, bone turnover, and longevity...
October 8, 2018: Climacteric: the Journal of the International Menopause Society
Elizabeth N Pearce
OBJECTIVE: To review the diagnosis and management of thyrotoxicosis in women who are preconception, pregnant, and in the postpartum period. METHODS: Literature review of English-language papers published 1980-2018. RESULTS: Overt thyrotoxicosis occurs in 0.2% of pregnancies and subclinical thyrotoxicosis in 2.5%. Hyperthyroidism in women of childbearing age most frequently is caused by Graves' disease. Gestational thyrotoxicosis, transient hCG-mediated hyperthyroidism, may develop in the first trimester of pregnancy...
October 5, 2018: Endocrine Practice
Karin van der Tuin, Leanne de Kock, Eveline J Kamping, Sabine E Hannema, Marie-Jose M Pouwels, Marek Niedziela, Tom van Wezel, Frederik J Hes, Marjolijn C Jongmans, William D Foulkes, Hans Morreau
Context: The DICER1 syndrome is a rare, autosomal dominant inherited disorder that predisposes to a variety of cancerous and noncancerous tumors of mostly pediatric- and adolescent-onset, including differentiated thyroid carcinoma (DTC). DICER1-related DTC has been hypothesized to arise secondary to the increased prevalence of pre-malignant lesions, i.e. thyroid hyperplastic nodules. Objective: To determine somatic alterations in DICER1-associated differentiated thyroid cancer and to study patient outcomes...
September 26, 2018: Journal of Clinical Endocrinology and Metabolism
Piotr Kmieć, Ilona Minkiewicz, Krzysztof Sworczak, Michał A Żmijewski, Konrad Kowalski
INTRODUCTION: In the context of pleiotropic vitamin D effects its role has also been investigated in thyroid pathology, in particular autoimmune thyroid diseases (AITD). However, available data concerning vitamin D status among Polish adult population are inconclusive. AIM: In the study we investigated vitamin D status and adequacy of supplementation, as well as sunlight exposure during summer months among adult patients with thyroid diseases. MATERIALS AND METHODS: Adults with diagnosed or suspected thyroid disease were recruited almost entirely in an ambulatory setting from June through September in Northern Poland...
September 27, 2018: Endokrynologia Polska
Xiang Li, Hui Li, Jing Zhao, Qi Dai, Chaoran Huang, Langping Jin, Fan Yang, Fuxue Chen, Ouchen Wang, Ying Gao
The incidences of nodular goiter (NG), thyroid adenoma (TA), and thyroid cancer (TC) are increasing rapidly; however, the etiologies of these diseases remain unclear. The present study aimed to evaluate the differences in plasma fatty acids among these three thyroid diseases to facilitate etiological research. Four ω-3 and seven ω-6 polyunsaturated fatty acids were measured from 97 TC, 14 TA and 11 NG patient plasma samples with gas chromatography-flame ionization detector. Fatty acids levels were expressed as the percentage of each fatty acid out of the total fatty acids evaluated...
October 2018: Oncology Letters
Ozgur Ekinci, Sumeyra Emine Boluk, Tunc Eren, Ibrahim Ali Ozemir, Salih Boluk, Artur Salmaslioglu, Metin Leblebici, Orhan Alimoglu
BACKGROUND: Nodular thyroid disease possesses the potential to harbor malignancy. Our aim was to evaluate the significance of cervical diffusion-weighted magnetic resonance imaging (DW-MRI) for the detection of malignant thyroid nodules. METHODS: Sixty-five thyroid nodules from 58 patients who had undergone surgery were evaluated. Preoperative parameters, demographic data, ultrasound findings, fine-needle aspiration biopsy results and apparent diffusion coefficient (ADC) values of the nodules at DW-MRI were compared with the results from postoperative pathology examinations...
September 14, 2018: Cirugía Española
Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Michał Kloska, Agata Czarnywojtek, Jerzy Sowiński, Bartłomiej Budny, Kosma Woliński, Katarzyna Ziemnicka, Dorota Mańkowska-Wierzbicka, Marek Ruchała
We aimed to analyze the potential influence of thyroid autoimmunity on visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients. This is a single-center, cross-sectional study with consecutive enrollment. All patients with newly diagnosed overt hyperthyroidism in a course of Graves' disease or toxic nodular goiter were included in the study. They underwent physical examination, laboratory investigation, body composition analysis, and thyroid ultrasound. NAMPT mRNA leukocyte expressions were measured using RT-qPCR...
September 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Juliane Léger, Isabelle Oliver, Danielle Rodrigue, Anne-Sophie Lambert, Régis Coutant
R1 The diagnosis of Graves' disease in children is based on detecting a suppression of serum TSH concentrations and the presence of anti-TSH receptor antibodies. 1/+++. R2 Thyroid ultrasound is unnecessary for diagnosis, but can be useful for assessing the size and homogeneity of the goiter. 2/+. R3. Thyroid scintigraphy is not required for the diagnosis of Graves' disease. 1/+++. R4. The measurement of T4L and T3L levels is not necessary for the diagnosis of Graves' disease in children but can be useful for the management and assessment of prognosis...
August 16, 2018: Annales D'endocrinologie
Michael C Yang, Saba Al-Hashimi, Daniel B Rootman
Salzmann's nodular degeneration (SND) typically occurs in patients who are female, 50-60 years old, and have a history of corneal inflammation and irritation. Multiple case reports have documented associations between SND and trachoma, viral infections, trauma, contact lens wear, corneal surgeries and corneal exposure. The authors describe a patient with bilateral SND confirmed by anterior segment optical coherence tomography (OCT) imaging in the context of thyroid eye disease (TED) and history of LASIK. Treatment involved propylthiouracil (PTU), artificial tear use, loteprednol etabonate ophthalmic gel, eyelid taping and selenium supplementation and prospective superficial keratectomy with diamond burr polish...
August 27, 2018: Orbit
Suvanjaa Sivalingam, Marianne Thvilum, Thomas Heiberg Brix, Laszlo Hegedüs, Frans Brandt
BACKGROUND: Season of birth, an exogenous indicator of early life environment, has been linked with a higher risk of adverse health outcomes such as autoimmune thyroiditis, multiple sclerosis and schizophrenia later in life. Whether the development and cause of hyperthyroidism is influenced by season of birth is unclarified. We aimed, at a nationwide level, to investigate whether season of birth influences the risk of hyperthyroidism due to Graves' disease (GD) and/or toxic nodular goitre (TNG)...
August 23, 2018: Endocrine Connections
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