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Nodular thyroid disease

Yasemin Aydoğan, Mustafa Altay, Oktay Ünsal, Veysel Kaplanoğlu, Yavuz Çağır, Canan Yıldız, Esin Beyan, Selma Uysal Ramadan
OBJECTIVES: Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA)...
August 6, 2018: Endocrine
B Kohnen, C Schürmeyer, T H Schürmeyer, P Kress
PURPOSE: Thyroid surgery is mainly performed by general surgeons (GS). The aim of this study is to evaluate the safety and efficiency of thyroid surgery by ENT/head and neck surgeons (ENT), especially regarding the incidence of vocal fold palsy (VFP). METHODS: We retrospectively analysed 3509 patients (69.0% female) who underwent surgery for benign thyroid diseases (56.8% nodular goitre, 18.6% inactive nodes, 14.0% thyroid autonomy, 7.0% Graves' disease). Operations were mainly performed with intraoperative neuromonitoring by GS (n = 1933) or physicians trained for head and neck surgery (n = 1576)...
August 3, 2018: European Archives of Oto-rhino-laryngology
Kevin C Choong, Amer Khiyami, Stephen W Tamarkin, Christopher R McHenry
BACKGROUND: Current guidelines recommend either ultrasound-guided or palpation-guided fine-needle aspiration biopsy for evaluation of a thyroid nodule. However, it has been suggested that ultrasound-guided fine-needle aspiration biopsy should be used routinely in all patients to reduce the rate of nondiagnostic and false negative results. The purpose of this study was to determine whether any difference exists in nondiagnostic and false negative rates between the two methods of fine-needle aspiration biopsy at our institution...
July 30, 2018: Surgery
Tatiana Ţăranu, Mirela Grigorovici, Magda Constantin, Mihaela Paula Toader
Dear Editor, Subcutaneous granuloma annulare (SGA) is considered a rare clinical variant of granuloma annulare, a common self-healing chronic inflammatory disorder that may appear in childhood as well as in adult age (1-3). A 29-year-old female patient reported the onset of several small subcutaneous nodules on the dorsal aspect of the second interphalangeal joint of the left medius finger and the left elbow, accompanied by vague joint pain, had occurred 13 years ago. Specific markers for rheumatoid arthritis were negative, leading to a diagnosis of sero-negative rheumatoid arthritis, for which treatment with methotrexate was initiated...
December 2017: Acta Dermatovenerologica Croatica: ADC
Helen H Shi, Christopher R McHenry
BACKGROUND: The purpose of this study was to determine the frequency of coexistent thyroid nodules and the rate of malignancy in patients with surgically treated Graves' disease (GD). METHODS: A retrospective review of all patients with GD who underwent thyroidectomy from 1990 to 2017 was completed. Pathology reports were reviewed for coexistent nodules. Demographics, nodule size, and results of ultrasound, 123 I scintigraphy, fine needle aspiration biopsy and pathology were analyzed...
July 19, 2018: American Journal of Surgery
Adele Latina, Elena Castellano, Flora Cesario, Alberto Boriano, Roberto Attanasio, Giorgio Borretta
OBJECTIVE: Primary hyperparathyroidism (PHPT) and thyroid diseases are highly prevalent in the general population, but the putative link between the 2 conditions remains unclear. METHODS: A monocentric consecutive series of 434 patients with PHPT was retrospectively evaluated by lab and ultrasonography to look for thyroid abnormalities. Patients were classified in 3 groups: without thyroid abnormalities (group 1, n = 171), with thyroid diseases not previously known (group 2a, n = 69), and thyroid diseases previously known (group 2b, n = 194)...
July 2018: Endocrine Practice
Nadia Sawicka-Gutaj, Marek Ruchala, Ulla Feldt-Rasmussen, Ase Krogh Rasmussen, Laszlo Hegedus, Steen Joop Bonnema, Mogens Groenvold, Jakob Bue Bjorner, Torquil Watt
BACKGROUND: This study aimed to describe the frequency of self-reported thyroid-related impaired sex life in patients with thyroid diseases, to examine its clinical correlates and relationship with overall quality of life (QOL), and to investigate the effect of treatment. PATIENTS AND METHODS: Two separate patient samples with benign thyroid diseases were investigated: a cross-sectional sample (759 women and 118 men) treated at two Danish university hospital outpatient clinics, in 2007-2008, and a longitudinal sample (358 women and 74 men) undergoing treatment at the abovementioned centers, during 2008-2012, evaluated before and 6 months after therapy...
July 24, 2018: Thyroid: Official Journal of the American Thyroid Association
Rosemary Wong, Stephen G Farrell, Mathis Grossmann
Thyroid nodules are common. Their importance lies in the need to assess thyroid function, degree of and future risk of mass effect, and exclude thyroid cancer, which occurs in 7-15% of thyroid nodules. There are four key components to thyroid nodule assessment: clinical history and examination, serum thyroid stimulating hormone (TSH) measurement, ultrasound and, if indicated, fine-needle aspiration (FNA). If the serum TSH is suppressed, a thyroid scan with 99 Tc can distinguish between a solitary hot nodule, a toxic multinodular goitre or, less commonly, thyroiditis or Graves' disease within a coexisting nodular thyroid...
July 16, 2018: Medical Journal of Australia
Ilgin Yildirim Simsir, Murat Ozdemir, Soner Duman, Mehmet Erdogan, Ayhan Donmez, Ahmet Gokhan Ozgen
PURPOSE: For the treatment of thyrotoxicosis, alternative treatment modalities may be necessary if anti-thyroid drugs cannot be used due to side effects, inefficiencies, or there is a need to start a rapid action such as thyroid storm. By using therapeutic plasma exchange (TPE), it is possible to effectively and rapidly remove the increased thyroid hormones. We evaluated our results and experience on a rapid, effective, and reliable alternative treatment modality in thyrotoxic patients...
July 2, 2018: Endocrine
Weihui Zheng, Kejing Wang, Junzhou Wu, Wendong Wang, Jinbiao Shang
Background: This study aimed to assess the predictive factor of multifocality to identify patients at high risk of central lymph node metastasis (CLNM). Patients and methods: Papillary thyroid microcarcinoma patients who underwent total or hemi-thyroidectomy with effective unilateral or bilateral central lymph node dissection were enrolled. Results: Multifocality, age, sex, tumor size, extrathyroidal extension, and nodular goiter were significantly associated with CLNM...
2018: Cancer Management and Research
Zeyad T Sahli, Ghedak Ansari, Merve Gurakar, Joseph K Canner, Dorry Segev, Martha A Zeiger, Aarti Mathur
BACKGROUND: The growth of the US geriatric population coupled with the rise in thyroid nodular disease and cancer will result in an increased number of thyroidectomies performed in older adults. We aim to evaluate outcomes after thyroidectomy in older adults as compared with younger adults. METHODS: A retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program database from 2012-2015 categorized thyroidectomy patients into three age groups: 18-64 y, 65-79 y, and ≥80 y...
September 2018: Journal of Surgical Research
D Januś, M Wójcik, A Taczanowska, P Sołtysiak, A Wędrychowicz, D Roztoczyńska, G Drabik, Ł Wyrobek, J B Starzyk
PURPOSE: To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. METHODS: A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background...
June 5, 2018: Journal of Endocrinological Investigation
Qingyi Jia, Xiaodan Li, Ying Liu, Ling Li, Joey Sw Kwong, Kaiyun Ren, Yong Jiang, Xin Sun, Haoming Tian, Sheyu Li
Background: The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD. Materials and methods: We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines...
2018: Cancer Management and Research
Leticia Mosca, Luiz Fernando Ferraz da Silva, Paulo Campos Carneiro, Danielle Azevedo Chacon, Vergilius Jose Furtado de Araujo-Neto, Vergilius Jose Furtado de Araujo-Filho, Claudio Roberto Cernea
OBJECTIVES: Most thyroid diseases are nodular and have been investigated using ultrasound-guided fine needle aspiration biopsy (FNAB), the reports of which are standardized by the Bethesda System. Bethesda category III represents a heterogeneous group in terms of lesion characteristics and the malignancy rates reported in the literature. The objective of the present study was to evaluate the differences in the malignancy rates among Bethesda III subcategories. METHODS: Data from 1,479 patients who had thyroid surgery were reviewed...
2018: Clinics
(no author information available yet)
BACKGROUND: The clinical value of the diagnosis of metabolic syndrome (MS) in children and adolescents remains unclear. The aim of the present study was to assess the occurrence of metabolic complications, other than included in 2007 IDF MS definition, in obese children and adolescents METHODS: The study included 75 (33 boys) obese adolescents (mean age 13.9 years, mean BMI SDS 4.49). Classical (fasting glucose, TGL, HDL, blood pressure) and non classical (insulin resistance [HOMA-IR], creatinine, AST, ALT, uric acid, fibrinogen, liver US and 24h BP profile) risk factors were compared between groups with and without MS...
May 19, 2018: Neuro Endocrinology Letters
Z N Tang, Y C Wang, X X Liu, Q L Liu
Objective: To investigate the expression and significance of CTHRC1 in patients with papillary thyroid cancinoma. Method: We collected 63 specimens of papillary thyroid carcinoma tissue with 36 specimens of the adjacent normal thyroid tissue and 23 specimens of thyroid nodular goiter. The expressions of CTHRC1 protein in these tissues were detected by immunohistochemical staining. The correlations between the expressions of CTHRC1 with clinicopathologic features,E-cadherin and Vimentin expression were analyzed...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
H Ma, L Li, K Li, T Wang, Y Zhang, C Zhang, Y Xu, X Wu, J Yu, H Wang, B Xiang, R Zhang, W Wang
Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto's thyroiditis(HT), nodular goiter(NG), Follicular adenoma(FA) and other types. However, the function of these diseases in PTC tumorigenesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Clinicopathological characteristics and BRAFV600E mutation status were compared between PTC and PTC+...
March 14, 2018: Neoplasma
Sezin Akman, Özlem Şahaloğlu, Ceyhun Dalkan, Nerin Nadir Bahçeciler, Çiğdem Arıkan
BACKGROUND/AIMS: Functional constipation is one of the common problems in childhood, and it comprises approximately 5% of the pediatric outpatient clinical applications. On the other hand, celiac disease (CD) is an immune enteropathy with the prevalence between 1/150 and 1/200. In addition to the classical symptoms of the disease such as diarrhea and weight loss, the incidence of atypical symptoms is increasing. This study aims to determine the prevalence of CD in patients with chronic constipation...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Chenlu Zhu, Shuxiang Li, Xin Gao, Gengchao Zhu, Miaoli Song, Fei Gao
BACKGROUND: Thyroid nodules are common, frequently discovered in clinical practice and the incidence has increased in recent decades. They are clinically important primarily due to their malignant potential, because 2 to 5% are malignant. Correct identification of the malignancy in thyroid nodules is a diagnostic challenge, leading to potentially unnecessary surgery in patients for whom final histology is benign. Because there is no accurate preoperative detection, it is very important to predict the risk of malignancy in patients with nodular thyroid disease...
March 1, 2018: Clinical Laboratory
Ángel Fernando Butrón-García, Mario Méndez-García
Introduction: Thyroid nodular disease is highly prevalent in the general population. Its diagnosis has increased with Doppler ultrasound, by means of which features suggestive of malignancy can be detected, such as resistance and pulsatility indices elevation. Objective: To assess the correlation of a high resistance index and histopathological findings in patients with ultrasonographic suspicion of malignant thyroid nodules. Method: Prospective, cross-sectional, analytic, observational study of diagnostic tests carried out at Specialty Hospital 25, in Monterrey, Nuevo León...
2018: Gaceta Médica de México
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