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https://www.readbyqxmd.com/read/28212953/the-influence-of-genotype-information-on-psychiatrists-treatment-recommendations-more-experienced-clinicians-know-better-what-to-ignore
#1
Alan J McMichael, Marco Boeri, Jonathan J Rolison, Joe Kane, Francis A O'Neill, Ric Scarpa, Frank Kee
BACKGROUND: This study applies attribute nonattendance to medical decision making. We aimed to demonstrate how this type of analysis can be used in medical decision making to assess whether psychiatrists were influenced in their treatment recommendations by information on the genotype of a patient, despite knowing the patient's response to treatment as measured by the Positive and Negative Syndrome Scale. A patient's genetic information may be used to predict their response to therapy; such information, however, becomes redundant, and should not influence decisions, once a clinician knows the patient's actual response to treatment...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28199798/the-hotel-study-clinical-and-health-service-effectiveness-in-a-cohort-of-homeless-or-marginally-housed-persons
#2
William G Honer, Alejandro Cervantes-Larios, Andrea A Jones, Fidel Vila-Rodriguez, Julio S Montaner, Howard Tran, Jimmy Nham, William J Panenka, Donna J Lang, Allen E Thornton, Talia Vertinsky, Alasdair M Barr, Ric M Procyshyn, Geoffrey N Smith, Tari Buchanan, Mel Krajden, Michael Krausz, G William MacEwan, Kristina M Gicas, Olga Leonova, Verena Langheimer, Alexander Rauscher, Krista Schultz
OBJECTIVE: The Hotel Study was initiated in Vancouver's Downtown East Side (DTES) neighborhood to investigate multimorbidity in homeless or marginally housed people. We evaluated the clinical effectiveness of existing, illness-specific treatment strategies and assessed the effectiveness of health care delivery for multimorbid illnesses. METHOD: For context, we mapped the housing locations of patients presenting for 552,062 visits to the catchment hospital emergency department (2005-2013)...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28192894/remote-ischemic-preconditioning-in-cardiac-anesthesia-a-review-focusing-on-translation
#3
Christian Stoppe, Patrick Meybohm, Carina Benstoem, Andreas Goetzenich
INTRODUCTION: Remote Ischaemic Conditioning (RIC) is a powerful cardioprotective strategy. Its clinical application is simple, cheap and so far free from secondary side effects. Given the heterogeneous results of recent large-scale clinical trials, its clinical relevant benefit is still doubted. EVIDENCE ACQUISITION: Following a MEDLINE-based search on all publications concerning RIC in experimental or clinical settings, this review focuses on the translation from bench to bedside...
February 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28192434/adverse-effects-of-mefloquine-for-the-treatment-of-uncomplicated-malaria-in-thailand-a-pooled-analysis-of-19-850-individual-patients
#4
Sue J Lee, Feiko O Ter Kuile, Ric N Price, Christine Luxemburger, François Nosten
Mefloquine (MQ) has been used for the treatment of malaria since the mid-1980s, first as monotherapy or as fixed combination with sulfadoxine-pyrimethamine (MSP) and since the mid-1990s in combination with artesunate. There is a renewed interested in MQ as part of a triple therapy for the treatment of multi-drug resistance P. falciparum malaria. The widespread use of MQ beyond south-East Asia has been constrained by reports of poor tolerability. Here we present the side effect profile of MQ for the treatment of uncomplicated malaria on the Thai-Myanmar/Cambodia borders...
2017: PloS One
https://www.readbyqxmd.com/read/28185378/ric-8a-an-activator-protein-of-g%C3%AE-i-controls-mammalian-epithelial-cell-polarity-for-tight-junction-assembly-and-cystogenesis
#5
Kanako Chishiki, Sachiko Kamakura, Junya Hayase, Hideki Sumimoto
Correct cyst morphogenesis of epithelial cells requires apical-basal polarization, which is partly regulated by mitotic spindle orientation, a process dependent on the heterotrimeric G protein subunit Gαi and its binding protein LGN. Here, we show that in three-dimensional culture of mammalian epithelial Madin-Darby canine kidney (MDCK) cells, the Gαi-activating protein Ric-8A is crucial for orientation of the mitotic spindle and formation of normal cysts that comprise a single layer of polarized cells with their apical surfaces lining an inner lumen...
February 10, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28135064/donor-acceptor-interface-stabilizer-based-on-fullerene-derivatives-toward-efficient-and-thermal-stable-organic-photovoltaics
#6
Junli Li, Xiaoguang Zhu, Tao Yuan, Jiulin Shen, Jikang Liu, Jian Zhang, Guoli Tu
An interface stabilizer based on alkylation-functionalized fullerene derivatives, [6, 6]-Phenyl-C61-butyric acid (3,5-bis(octyloxy)phenyl)methyl ester (PCB-C8oc), was successfully synthesized and applied for the active layer of Organic Photovoltaics (OPVs). The PCB-C8oc can replace part of the phenyl-C61-buty-ric acid methyl ester (PCBM) and be distributed on the interface of poly(3-hexylthiophene) (P3HT) and PCBM to form P3HT/PCBM/PCB-C8oc ternary blends, leading to thermally stable and efficient organic photovoltaics...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28129389/limited-clinical-utility-of-remote-ischemic-conditioning-in-renal-transplantation-a-meta-analysis-of-randomized-controlled-trials
#7
Chang-Cheng Zhou, Yu-Zheng Ge, Wen-Tao Yao, Ran Wu, Hui Xin, Tian-Ze Lu, Ming-Hao Li, Kai-Wei Song, Min Wang, Yun-Peng Zhu, Meng Zhu, Li-Guo Geng, Xiao-Fei Gao, Liu-Hua Zhou, Sheng-Li Zhang, Jia-Geng Zhu, Rui-Peng Jia
OBJECTIVE: We conducted this meta-analysis of randomized controlled trials (RCTs) to investigate whether remote ischemic conditioning (RIC) could improve graft functions in kidney transplantation. METHODS: PubMed, Web of Science, and Cochrane Library were comprehensively searched to identify all eligible studies by October 5, 2016. The treatment effects were examined with risk ratio (RR) and weighted mean difference with the corresponding 95% confidence intervals (CI)...
2017: PloS One
https://www.readbyqxmd.com/read/28128692/volume-staged-versus-dose-staged-stereotactic-radiosurgery-outcomes-for-large-brain-arteriovenous-malformations-a-systematic-review
#8
Adeel Ilyas, Ching-Jen Chen, Dale Ding, Davis G Taylor, Shayan Moosa, Cheng-Chia Lee, Or Cohen-Inbar, Jason P Sheehan
OBJECTIVE Several recent studies have improved our understanding of the outcomes of volume-staged (VS) and dose-staged (DS) stereotactic radiosurgery (SRS) for the treatment of large (volume > 10 cm(3)) brain arteriovenous malformations (AVMs). In light of these recent additions to the literature, the aim of this systematic review is to provide an updated comparison of VS-SRS and DS-SRS for large AVMs. METHODS A systematic review of the literature was performed using PubMed to identify cohorts of 5 or more patients with large AVMs who had been treated with VS-SRS or DS-SRS...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28121993/a-comparison-of-three-quantitative-methods-to-estimate-g6pd-activity-in-the-chittagong-hill-tracts-bangladesh
#9
Benedikt Ley, Mohammad Shafiul Alam, James J O'Donnell, Mohammad Sharif Hossain, Mohammad Golam Kibria, Nusrat Jahan, Wasif A Khan, Kamala Thriemer, Mark D Chatfield, Ric N Price, Jack S Richards
BACKGROUND: Glucose-6-phosphate-dehydrogenase-deficiency (G6PDd) is a major risk factor for primaquine-induced haemolysis. There is a need for improved point-of-care and laboratory-based G6PD diagnostics to unsure safe use of primaquine. METHODS: G6PD activities of participants in a cross-sectional survey in Bangladesh were assessed using two novel quantitative assays, the modified WST-8 test and the CareStart™ G6PD Biosensor (Access Bio), The results were compared with a gold standard UV spectrophotometry assay (Randox)...
2017: PloS One
https://www.readbyqxmd.com/read/28117441/plasmodium-malariae-and-p-ovale-genomes-provide-insights-into-malaria-parasite-evolution
#10
Gavin G Rutledge, Ulrike Böhme, Mandy Sanders, Adam J Reid, James A Cotton, Oumou Maiga-Ascofare, Abdoulaye A Djimdé, Tobias O Apinjoh, Lucas Amenga-Etego, Magnus Manske, John W Barnwell, François Renaud, Benjamin Ollomo, Franck Prugnolle, Nicholas M Anstey, Sarah Auburn, Ric N Price, James S McCarthy, Dominic P Kwiatkowski, Chris I Newbold, Matthew Berriman, Thomas D Otto
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri). These species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. The exact evolutionary relationship of these species to the other human-infective species has been contested...
January 25, 2017: Nature
https://www.readbyqxmd.com/read/28117388/identification-of-key-residues-for-urate-specific-transport-in-human-glucose-transporter-9-hslc2a9
#11
Wentong Long, Rashmi Panigrahi, Pankaj Panwar, Kenneth Wong, Debbie O Neill, Xing-Zhen Chen, M Joanne Lemieux, Chris I Cheeseman
Human glucose transporter 9 (hSLC2A9) is critical in human urate homeostasis, for which very small deviations can lead to chronic or acute metabolic disorders. Human SLC2A9 is unique in that it transports hexoses as well as the organic anion, urate. This ability is in contrast to other homologous sugar transporters such as glucose transporters 1 and 5 (SLC2A1 &SLC2A5) and the xylose transporter (XylE), despite the fact that these transporters have similar protein structures. Our in silico substrate docking study has revealed that urate and fructose bind within the same binding pocket in hSLC2A9, yet with distinct orientations, and allowed us to identify novel residues for urate binding...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28112749/reduced-intensity-conditioning-allogeneic-hematopoietic-cell-transplantation-for-younger-patients-with-acute-myeloid-leukemia-a-registry-based-study
#12
M Yanada, S Kurosawa, T Kobayashi, Y Ozawa, H Kanamori, N Kobayashi, M Sawa, H Nakamae, N Uchida, H Hashimoto, T Fukuda, M Hirokawa, Y Atsuta, S Yano
Clinical efficacy of allogeneic hematopoietic cell transplantation (HCT) using reduced-intensity conditioning (RIC) for younger patients remains unclear. We therefore performed a retrospective registry-based study to evaluate outcomes for patients with AML aged between 16 and 49 years who underwent RIC allogeneic HCT. Patients receiving RIC (N=125) showed significantly worse survival than those receiving myeloablative conditioning (MAC; N=1,554) (47.7% for RIC and 54.2% for MAC at 4 years, P=0.047). However, the difference became marginal after adjustment for patient characteristics (P=0...
January 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28095644/xenopus-as-a-model-organism-to-study-heterotrimeric-g-protein-pathway-during-collective-cell-migration-of-neural-crest
#13
REVIEW
G Toro-Tapia, S Villaseca, J I Leal, A Beyer, J Fuentealba, M Torrejón
Collective cell migration is essential in many fundamental aspects of normal development, like morphogenesis, organ formation, wound healing, and immune responses, as well as in the etiology of severe pathologies, like cancer metastasis. In spite of the huge amount of data accumulated on cell migration, such a complex process involves many molecular actors, some of which still remain to be functionally characterized. One of these signals is the heterotrimeric G-protein pathway that has been studied mainly in gastrulation movements...
January 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28089934/evaluation-of-aggregate-and-silicone-oil-counts-in-pre-filled-siliconized-syringes-an-orthogonal-study-characterising-the-entire-subvisible-size-range
#14
Maryam Shah, Zahra Rattray, Katie Day, Shahid Uddin, Robin Curtis, Christopher F van der Walle, Alain Pluen
Characterisation of particulates in therapeutic monoclonal antibody (mAb) formulations is routinely extended to the sub-visible size-range (0.1-10μm). Additionally, with the increased use of pre-filled syringes (PFS), particle differentiation is required between proteinaceous and non-proteinaceous particles such as silicone-oil droplets. Here, three orthogonal techniques: Raster Image Correlation Spectroscopy (RICS), Resonance Mass Measurements (RMM) and Micro-Flow Imaging (MFI), were evaluated with respect to their sub-visible particle measurement and characterisation capabilities...
January 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28089878/pretransplant-absolute-lymphocyte-counts-impact-the-pharmacokinetics-of-alemtuzumab
#15
Rebecca Marsh, Tsuyoshi Fukuda, Chie Emoto, Lisa Neumeier, Pooja Khandelwal, Sharat Chandra, Ashley Teusink, Alexander Vinks, Parinda A Mehta
Alemtuzumab is frequently used as part of reduced-intensity conditioning (RIC) regimens for allogeneic hematopoietic cell transplantation (HCT) in pediatric patients with nonmalignant diseases. We previously suggested an optimal day 0 targeted range of alemtuzumab, but there are no pediatric data regarding the pharmacokinetics (PK) of subcutaneous alemtuzumab to guide precision dosing trials. The goal of this study was to prospectively characterize alemtuzumab PK and to explore absolute lymphocyte count (ALC) as a predictor of interindividual variability...
January 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28088220/anti-inflammatory-potential-of-ellagic-acid-gallic-acid-and-punicalagin-a-b-isolated-from-punica-granatum
#16
Lamees A BenSaad, Kah Hwi Kim, Chin Chew Quah, Wee Ric Kim, Mustafa Shahimi
BACKGROUND: Punica granatum (pomegranate), an edible fruit originating in the Middle East, has been used as a traditional medicine for treatment of pain and inflammatory conditions such as peptic ulcer. The numerous risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for treatment of pain and inflammation give rise to using medicinal herbs as alternative therapies. This study aimed to evaluate the anti-inflammatory effect of isolated compounds from the ethyl acetate (EtOAc) fraction of P...
January 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28072872/population-pharmacokinetic-properties-of-piperaquine-in-falciparum-malaria-an-individual-participant-data-meta-analysis
#17
Richard M Hoglund, Lesley Workman, Michael D Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N Price, Prabin Dahal, Nancy C Sambol, Sunil Parikh, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Khin Maung Lwin, Rose McGready, Nicholas P J Day, Philippe J Guerin, Nicholas J White, Karen I Barnes, Joel Tarning
BACKGROUND: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated Plasmodium falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs currently recommended by the World Health Organization. Previous studies suggest that young children (<5 y) with malaria are under-dosed. This study utilised a population-based pharmacokinetic approach to optimise the antimalarial treatment regimen for piperaquine...
2017: PLoS Medicine
https://www.readbyqxmd.com/read/28069702/remote-ischemic-conditioning-provides-humoural-cross-species-cardioprotection-through-glycine-receptor-activation
#18
Juan José Alburquerque-Béjar, Ignasi Barba, Laura Valls-Lacalle, Marisol Ruiz-Meana, Michela Pecoraro, Antonio Rodríguez-Sinovas, David García-Dorado
AIMS: Remote ischaemic conditioning (RIC) releases a humoural factor able to exert cross-species cardioprotection when plasma dialysate is applied to isolated hearts. However, the exact chemical nature of this factor is currently unknown. METHODS AND RESULTS: RIC (4 × 5min femoral occlusion/5min reperfusion) was applied to 10 male pigs, and blood was taken before and after the manoeuvre. Discriminant analysis of (1)H-NMR spectra (n = 10-12) obtained from plasma dialysates (12-14 kDa cut-off) allowed to demonstrate a different metabolic profile between control and postRIC samples, with lactate (2...
January 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28067872/reduced-intensity-and-non-myeloablative-allogeneic-stem-cell-transplantation-from-alternative-hla-mismatched-donors-for-hodgkin-lymphoma-a-study-by-the-french-society-of-bone-marrow-transplantation-and-cellular-therapy
#19
J Gauthier, L Castagna, F Garnier, T Guillaume, G Socié, S Maury, N Maillard, R Tabrizi, T Marchand, J Malfuson, A Gac, E Gyan, M Mercier, Y Béguin, J Delage, P Turlure, A Marçais, S Nguyen, R Dulery, J Bay, A Huynh, E Daguindau, J Cornillon, C Régny, M Michallet, R Peffault de Latour, I Yakoub-Agha, D Blaise
Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed Hodgkin lymphoma (HL). When an HLA-matched donor is lacking a graft from a familial haploidentical (HAPLO) donor, a mismatched unrelated donor (MMUD) or cord blood (CB) might be considered. In this retrospective study, we compared the outcome of patients with HL undergoing a RIC or NMA allo-SCT from HAPLO, MMUD or CB...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28065491/meta-analysis-of-randomized-trials-on-remote-ischemic-conditioning-during-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#20
Ayman Elbadawi, Le Dung Ha, Ahmed S Abuzaid, Gabriele Crimi, Muhammad S Azzouz
Ischemia/reperfusion injury adversely affects the final infarct size (IS) after primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). Few studies have evaluated the role of remote ischemic conditioning (RIC) in reducing ischemia/reperfusion injury. However, the results of these studies were not consistent, and an overview of overall effectiveness of this technique in patients with STEMI is lacking. We conducted this meta-analysis to evaluate the available evidence in literature regarding the application of RIC in patients with STEMI who underwent primary PCI...
December 21, 2016: American Journal of Cardiology
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