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Diabetes And Cardio

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https://www.readbyqxmd.com/read/30120425/understanding-the-complexity-of-glycaemic-health-systematic-bio-psychosocial-modelling-of-fasting-glucose-in-middle-age-adults-a-dynahealth-study
#1
Estelle Lowry, Nina Rautio, Ville Karhunen, Jouko Miettunen, Leena Ala-Mursula, Juha Auvinen, Sirkka Keinänen-Kiukaanniemi, Katri Puukka, Inga Prokopenko, Karl-Heinz Herzig, Alexandra Lewin, Sylvain Sebert, Marjo-Riitta Järvelin
BACKGROUND: The prevention of the risk of type 2 diabetes (T2D) is complicated by multidimensional interplays between biological and psychosocial factors acting at the individual level. To address the challenge we took a systematic approach, to explore the bio-psychosocial predictors of blood glucose in mid-age. METHODS: Based on the 31-year and 46-year follow-ups (5,078 participants, 43% male) of Northern Finland Birth Cohort 1966, we used a systematic strategy to select bio-psychosocial variables at 31 years to enable a data-driven approach...
August 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/30113681/development-of-an-algorithm-to-link-electronic-health-record-prescriptions-with-pharmacy-dispense-claims
#2
Megan Hoopes, Heather Angier, Lewis A Raynor, Andrew Suchocki, John Muench, Miguel Marino, Pedro Rivera, Nathalie Huguet
Objective: Medication adherence is an important aspect of chronic disease management. Electronic health record (EHR) data are often not linked to dispensing data, limiting clinicians' understanding of which of their patients fill their medications, and how to tailor care appropriately. We aimed to develop an algorithm to link EHR prescribing to claims-based dispensing data and use the results to quantify how often patients with diabetes filled prescribed chronic disease medications. Materials and Methods: We developed an algorithm linking EHR prescribing data (RxNorm terminology) to claims-based dispensing data (NDC terminology), within sample of adult (19-64) community health center (CHC) patients with diabetes from a network of CHCs across 12 states...
August 3, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/30113145/cardio-ankle-vascular-index-as-a-surrogate-marker-of-early-atherosclerotic-cardiovascular-disease-in-koreans-with-type-2-diabetes-mellitus
#3
So Young Park, Sang Ook Chin, Sang Youl Rhee, Seungjoon Oh, Jeong Taek Woo, Sung Woon Kim, Suk Chon
BACKGROUND: Carotid artery intima medial thickness (IMT), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) are commonly used surrogate markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The cardio-ankle vascular index (CAVI) is a complement to the baPWV, which is affected by blood pressure. However, it is unclear which marker is the most sensitive predictor of atherosclerotic cardiovascular disease (ASCVD). METHODS: This was a retrospective non-interventional study that enrolled 219 patients with T2DM...
July 27, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30113051/metabolic-and-genetic-response-to-probiotics-supplementation-in-patients-with-diabetic-nephropathy-a-randomized-double-blind-placebo-controlled-trial
#4
Alireza Mafi, Gholamreza Namazi, Alireza Soleimani, Fereshteh Bahmani, Esmat Aghadavod, Zatollah Asemi
This study was carried out to evaluate the effects of probiotics administration on the metabolic and genetic profiles in patients with diabetic nephropathy (DN). This was a randomized, placebo-controlled clinical trial with homeostasis model of assessment-estimated insulin resistance (HOMA-IR) as the primary and other metabolic profiles, and biomarkers of inflammation and oxidative stress as the secondary outcomes. This randomized, double-blind, placebo-controlled clinical trial was performed on 60 patients with DN...
August 16, 2018: Food & Function
https://www.readbyqxmd.com/read/30089337/polycystic-ovary-syndrome-and-the-risk-of-cardio-metabolic-complications-in-longitudinal-studies-a-review-of-the-data
#5
REVIEW
Małgorzata Jacewicz-Święcka, Irina Kowalska
The purpose of this study was to perform a review of the longitudinal studies to determine whether polycystic ovary syndrome (PCOS) is associated with higher prevalence of metabolic complications and cardiovascular (CV) morbidity and mortality. The primary outcomes included body mass index (BMI), metabolic syndrome (MetS) and its components [waist circumference (WC), lipids profile, arterial hypertension (AH), abnormal glucose metabolism (impaired fasting glucose IFG, impaired glucose tolerance IGT, type 2 diabetes mellitus T2DM)], insulin resistance (IR) and cardiovascular diseases (CVD) like stroke, angina and coronary heart disease (CHD)...
August 8, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30081468/different-risk-for-hypertension-diabetes-dyslipidemia-and-hyperuricemia-according-to-level-of-body-mass-index-in-japanese-and-american-subjects
#6
Masanari Kuwabara, Remi Kuwabara, Koichiro Niwa, Ichiro Hisatome, Gerard Smits, Carlos A Roncal-Jimenez, Paul S MacLean, Joseph M Yracheta, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson, Diana I Jalal
Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia. Here, we evaluated whether the same body mass index (BMI) for the U.S. population conferred similar metabolic risk in Japan. This was a cross-sectional analysis involving 90,047 Japanese adults (18⁻85 years) from St. Luke's International Hospital, Tokyo, Japan and 14,734 adults from National Health and Nutrition Examination Survey (NHANES) collected in the U.S. We compared the prevalence of hypertension, DM, dyslipidemia, and hyperuricemia according to BMI in Japan and the U...
August 3, 2018: Nutrients
https://www.readbyqxmd.com/read/30060302/-prevalence-of-cardio-metabolic-risk-factors-and-related-socio-demographic-factors-in-adults-aged-18-59-years-in-15-provinces-of-china
#7
Z H Wang, B Zhang, H J Wang, L S Wang, G G Ding
Objective: To analyze the prevalence and co-prevalence of cardio metabolic (CM) risk factors in adults in China. Methods: The project data of 2015 Nutritional Status and Health Transition of Chinese Residents were used, and 5 456 adults aged 18-59 years with complete socio-demographic, anthropometric, and blood biochemical data were selected as the study subjects. The definition released by the International Diabetes Federation in 2005 were used to define each CM risk factors, including central obesity, elevated TG, reduced HDL-C, elevated blood pressure and elevated FPG...
July 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/30060124/urine-tricarboxylic-acid-tca-cycle-metabolites-predict-progressive-chronic-kidney-disease-in-type-2-diabetes
#8
Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Jianhong Ching, Jean-Paul Kovalik, Tsze Yin Tan, Su Chi Lim
Context: Metabolites in tricarboxylic acid (TCA) cycle are not only involved in energy metabolism but also play important roles in non-energy production activities. Objective: To study whether baseline urine key TCA cycle metabolites (lactate, pyruvate, citrate, alpha-ketoglutaric acid, succinate, fumarate and malate) may independently predict risk of chronic kidney disease (CKD) progression (fast eGFR decline) in individuals with type 2 diabetes mellitus (T2DM)...
July 27, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30051402/cardiovascular-implications-of-diabetes-metabolic-syndrome-thyroid-disease-and-cardio-oncology-in-women
#9
Marijana Tadic, Cesare Cuspidi, Dragan Vasic, Peter L M Kerkhof
Cardiovascular disease may be associated with several comorbidities, including diabetes mellitus, thyroid disorders, and the metabolic syndrome, which are predominantly observed in women and often starting at particular ages. In addition, common treatment options for carcinomas frequently seen in women may induce serious cardiotoxic effects. We review the scope of the problem, the pathophysiologic mechanisms involved, as well as the resulting abnormalities regarding cardiac structure and function as observed by using imaging techniques...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30037630/preliminary-results-of-the-multicenter-observational-study-with-enoximone-in-cardiac-surgery-mosec
#10
Emiliano Angeloni, Giovanni Melina, Francesco Federici, Francesca Pischedda, Walter Vignaroli, Monica Rocco, Riccardo Sinatra
BACKGROUND: Perioperative administration of Enoximone has been shown to improve hemodynamics, organ function, and inflammatory response. Aim of the present study was to evaluate the effects of Enoximone after on-pump cardiac surgery. METHODS: A protocol for a multicenter observational study was reviewed and approved by local ethic committee. This preliminary report involves the first 29 patients enrolled, in whom Enoximone was perioperatively administered in the context of on-pump cardiac surgery...
July 19, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30037123/dietary-fibre-as-a-unifying-remedy-for-the-whole-spectrum-of-obesity-associated-cardiovascular-risk
#11
REVIEW
Lutgarda Bozzetto, Giuseppina Costabile, Giuseppe Della Pepa, Paola Ciciola, Claudia Vetrani, Marilena Vitale, Angela A Rivellese, Giovanni Annuzzi
Obesity is a pandemic carrying the heavy burden of multiple and serious co-morbidities including metabolic syndrome, type 2 diabetes and cardiovascular diseases. The pathophysiological processes leading to the accumulation of body fat slowly evolve to fat accumulation in other body compartments than subcutaneous tissue. This abnormal fat deposition determines insulin resistance which in turn causes blood glucose and lipid metabolism derangement, non-alcoholic fatty liver disease, hypertension, and metabolic syndrome...
July 21, 2018: Nutrients
https://www.readbyqxmd.com/read/30026334/renal-and-cardiovascular-risk-according-to-tertiles-of-urinary-albumin-to-creatinine-ratio-the-adolescent-type-1-diabetes-cardio-renal-intervention-trial-addit
#12
M Loredana Marcovecchio, Scott T Chiesa, Jane Armitage, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, R Neil Dalton, John Deanfield, David B Dunger
OBJECTIVE: Baseline data from the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) indicated that tertiles of urinary albumin-to-creatinine ratios (ACRs) in the normal range at age 10-16 years are associated with risk markers for diabetic nephropathy (DN) and cardiovascular disease (CVD). We aimed to determine whether the top ACR tertile remained associated with DN and CVD risk over the 2-4-year AdDIT study. RESEARCH DESIGN AND METHODS: One hundred fifty adolescents (mean age 14...
July 19, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30023052/association-between-life-course-socio-economic-status-and-prevalence-of-cardio-metabolic-risk-ractors-in-five-middle-income-countries
#13
Kemi Ogunsina, Daniel T Dibaba, Tomi Akinyemiju
Background: The burden of non-communicable diseases has increased rapidly in low- and middle-income countries. Past studies have reported an association between socioeconomic status (SES) and cardio-metabolic risk factors, but most have focused on upper income countries. The purpose of this study is to examine the association between SES over the life-course and the burden of cardio-metabolic risk factors in middle-income countries. Methods: A total of 38 297 adults from China, Mexico, India, South Africa and Russia were included in this cross-sectional study...
December 2018: Journal of Global Health
https://www.readbyqxmd.com/read/30020454/one-hour-post-load-hyperglycemia-implications-for-prediction-and-prevention-of-type-2-diabetes
#14
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Francesco Andreozzi, Maria Perticone, Marta Letizia Hribal, Angela Sciacqua, Francesco Perticone, Giorgio Sesti
Context: Recently, a value of 1-h post-load glucose concentration (1-h-PG) ≥155 mg/dl (8.6 mmol/l) in individuals with normal glucose tolerance (NGT) has been found to be associated with an increased risk for future type 2 diabetes (T2DM). In this review, we analyze the implication of 1-h-PG determination in prediction of T2DM and cardiovascular disease. Evidence Acquisition: A literature search was performed using MEDLINE. We included all English studies published up to February 2018 in peer-reviewed journals that examined the relationship between 1-h-PG and diabetes, cardio-metabolic alterations, organ damage, and cardiovascular disease...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30020326/influence-of-type-1-diabetes-on-the-symbolic-analysis-and-complexity-of-heart-rate-variability-in-young-adults
#15
Elaine Aparecida de Oliveira, Anne Kastelianne França da Silva, Diego Giuliano Destro Christofaro, Laís Manata Vanzella, Rayana Loch Gomes, Franciele Marques Vanderlei, Luiz Carlos Marques Vanderlei
BACKGROUND: Type 1 diabetes mellitus can cause autonomic changes, which can be assessed by heart rate variability. Among the heart rate variability assessment methods, the symbolic analysis and Shannon entropy, based on the Chaotic dynamics, have gained prominence. OBJECTIVE: To compare heart rate variability indexes, obtained through symbolic analysis and Shannon entropy, in young adults with type 1 diabetes mellitus and healthy young individuals, associated with the analysis of linear indexes; and to verify if there are associations between the indexes obtained by the symbolic analysis and by Shannon entropy and linear indexes in diabetic individuals...
July 16, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/30017504/a-comparison-of-the-sensitivity-and-specificity-of-anthropometric-measurements-to-predict-unhealthy-metabolic-phenotype-in-overweight-and-obese-women
#16
Niloufar Rasaei, Atieh Mirzababaei, Hana Arghavani, Somayeh Tajik, Seyed Ali Keshavarz, Mir Saeed Yekaninejad, Hossein Imani, Khadijeh Mirzaei
AIM: Metabolically Healthy Obese (MHO) is called to obese people that their insulin sensitivity, lipid profiles and inflammatory profiles are favorable, and there are no signs of hypertension and cardio-metabolic diseases. The metabolically unhealthy obese (MUHO) is the opposite. A Body Shape Index (ABSI) is a marker to identifying abdominal obesity that is derived from weight, height and waist circumference (WC). Several studies have reported ABSI is associated with diabetes, metabolic syndrome, hypertension and higher mortality rate...
July 8, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/30006585/inflammation-linked-adaptations-in-dermal-microvascular-reactivity-accompany-the-development-of-obesity-and-type-2-diabetes
#17
Marie-Sophie Nguyen-Tu, Pierre Nivoit, Valérie Oréa, Sandrine Lemoine, Cécile Acquaviva, Aurélie Pagnon-Minot, Bérengère Fromy, Jaswinder K Sethi, Dominique Sigaudo-Roussel
BACKGROUND/OBJECTIVES: The increased prevalence of obesity has prompted great strides in our understanding of specific adipose depots and their involvement in cardio-metabolic health. However, the impact of obesity on dermal white adipose tissue (dWAT) and dermal microvascular functionality remains unclear. This study aimed to investigate the temporal changes that occur in dWAT and dermal microvascular functionality during the development of diet-induced obesity and type 2 diabetes in mice...
July 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/30002461/relationship-between-systemic-vascular-characteristics-and-retinal-nerve-fiber-layer-loss-in-patients-with-type-2-diabetes
#18
Soo Ji Jeon, Hae-Young Lopilly Park, Jae Hyung Lee, Chan Kee Park
Retinal nerve fiber layer (RNFL) loss in diabetic patients is especially common regardless of diabetic retinopathy (DR). The correlations between nonglaucomatous RNFL loss and systemic characteristics in diabetic patients have aroused interests in many aspects. 167 subjects with type 2 diabetes who underwent evaluation for arterial stiffness and cardiovascular autonomic function using heart rate variability (HRV) were included in this study. Arterial stiffness was measured using cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI)...
July 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29989097/smoke-exposure-and-cardio-metabolic-profile-in-youth-with-type-1-diabetes
#19
Valeria Calcaterra, Jonathan P Winickoff, Catherine Klersy, Luca Maria Schiano, Rossella Bazzano, Chiara Montalbano, Valeria Musella, Corrado Regalbuto, Daniela Larizza, Hellas Cena
Background: To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D). Patients and methods: We enrolled 104 children and young adults (50 females and 54 males) with T1D (aged 16.4 ± 8.6 years). The subjects were divided into three groups according to their smoking habits: no smoking (NS), passive smoking (PS), active smoking (AS). The physical examination of the participants included nutritional status assessment by anthropometry and pubertal stage according to Marshall and Tanner as well as blood pressure measurement...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29987919/n-terminal-pro-brain-natriuretic-peptide-nt-probnp-predicts-the-cardio-renal-response-to-aliskiren-in-patients-with-type-2-diabetes-at-high-renal-and-cardiovascular-risk
#20
Nienke M A Idzerda, Frederik Persson, Michelle J Pena, Barry M Brenner, Patrick Brunel, Nish Chaturvedi, John J McMurray, Hans-Henrik Parving, Dick de Zeeuw, Hiddo J L Heerspink
Sodium retention and volume overload are the main determinants of poor response to renin-angiotensin-aldosterone system (RAAS) inhibition in patients with diabetes. As volume excess can exist without symptoms, biomarkers are needed to identify a priori which patients are volume overloaded and may experience less benefit from RAAS inhibition. N-terminal pro-brain natriuretic peptide (NT-proBNP) is released in the setting of increased cardiac wall stress and volume overload. We conducted a post hoc analysis among 5081 patients with type 2 diabetes mellitus participating in the ALTITUDE trial to investigate whether NTproBNP can predict the effects of additional therapy with aliskiren on cardio-renal endpoints...
July 10, 2018: Diabetes, Obesity & Metabolism
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