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https://www.readbyqxmd.com/read/29206367/gall-bladder-cancer
#1
REVIEW
Audrey E Ertel, David Bentrem, Daniel E Abbott
Gallbladder carcinoma (GBC) is the most common biliary epithelial malignancy, with an estimated 10,910 new cases and 3700 deaths per year (Siegel et al. in CA Cancer J Clin 65:5–29, 2015 [1]). This disease’s insidious nature and typically late presentation place it among the most lethal of invasive neoplasms. Gallbladder cancer spreads early by lymphatic or hematogenous metastasis and by direct invasion into the liver. While surgery may well be curative at early stages, both surgical and nonsurgical treatments remain largely unsuccessful in patients with more advanced disease...
2016: Cancer Treatment and Research
https://www.readbyqxmd.com/read/28892903/immunohistochemical-study-of-muc1-and-muc5ac-expression-in-gall-bladder-lesions
#2
Amit Bhoge, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Bageshri Gogate, Maithili Mandar Kulkarni, Pallavi Bhayekar
INTRODUCTION: Immunohistochemical (IHC) markers of mucin family are associated with various Gallbladder Lesions (GBLs). AIM: To study the distribution of GBL with respect to age and sex as well as to analyse the IHC profile of MUC1 and MUC5AC in GBLs and attempt correlation with clinical and histopathological findings. MATERIALS AND METHODS: The present study was conducted over a period of six years. A technique of manual tissue array was employed for cases subjected to IHC using MUC1 and MUC5AC...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28625681/variation-of-calcium-copper-and-iron-levels-in-serum-bile-and-stone-samples-of-patients-having-different-types-of-gallstone-a-comparative-study
#3
COMPARATIVE STUDY
Mustafa Khan, Tasneem Gul Kazi, Hassan Imran Afridi, Sirajuddin, Muhammad Bilal, Asma Akhtar, Sabir Khan, Salma Kadar
BACKGROUND: Epidemiological data among the human population has shown a significantly increased incidence of gallstone (GS) disease worldwide. It was studied that some essential (calcium) and transition elements (iron and copper) in bile play an important role in the development of GS. METHOD: The estimation of calcium, copper and iron were carried out in the serum, gall bladder bile and different types of GS (cholesterol, mixed and pigmented) of 172 patients, age ranged 20-55years...
August 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27211249/second-line-palliative-chemotherapy-in-advanced-gall-bladder-cancer-cap-iri-safe-and-effective-option
#4
Anant Ramaswamy, Vikas Ostwal, Nikhil Pande, Arvind Sahu, Sunny Jandyal, Mukta Ramadwar, Nitin Shetty, Shraddha Patkar, Mahesh Goel, Sudeep Gupta
INTRODUCTION: Gall bladder cancer (GBC) has high prevalence in the Indo-Gangetic belt in India. While the first-line chemotherapy (CT1) has been established as gemcitabine-platinum doublet in advanced GBC, there is no standard recommendation or guidelines regarding feasibility of second-line therapy. METHODS: We performed a retrospective analysis of all patients who received second-line of chemotherapy (CT2) at our institution from July 2012 to December 2014. Patient records were examined for efficacy and toxicity of administered CT2, along with response rates (RR) and survival...
September 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/26393162/expression-of-cck-receptors-in-carcinoma-gallbladder-and-cholelithiasis-a-pilot-study
#5
Mohammad Shazib Faridi, Mahabir Saran Das Jaiswal, Sudhir K Goel
BACKGROUND: Gastrin and cholecystokinin (CCK) receptors are trophic for various gastrointestinal malignancies. Their role in gallbladder cancer has not been widely studied. OBJECTIVES: To identify expression of CCK-A and CCK-B receptors in the tissue and blood of patients suffering from carcinoma (CA) gallbladder and gallstone disease and to compare expression of CCK A and B receptors in the gall bladder tissue and blood of healthy individuals and patients of CA gallbladder, and gallstone diseases...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26172570/ghrelin-receptor-in-japanese-fire-belly-newt-cynops-pyrrhogaster
#6
Hiroyuki Kaiya, Kenji Kangawa, Mikiya Miyazato
We identified cDNA encoding a functional ghrelin receptor (growth hormone secretagogue-receptor 1a (GHS-R1a)) in a urodele amphibian, the Japanese fire belly newt (Cynops pyrrhogaster). Two functional receptor proteins, composed of 378- and 362-amino acids, were deduced from the identified cDNA because two candidate initiation methionine sites were found. The long-chain receptor protein shared 80%, 69%, and 59% identities with the bullfrog GHS-R1a, human GHS-R1a and tilapia GHS-R1a-like receptor, respectively...
November 2015: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/25829706/to-study-serum-iron-levels-in-patients-of-gall-bladder-stone-disease-and-to-compare-with-healthy-individuals
#7
P C Prasad, Subodh Gupta, Nitin Kaushik
Gallstone disease is a common gastrointestinal problem in day-to-day practice. The Old concept that a typical gallstone sufferer is fat, fertile, flatulent female of 50. This is partially true as the disease has been found in women soon after their first delivery who are thin and underweight and in males also. Conditions that favor the formation of cholesterol gallstones are super saturation of bile with cholesterol, kinetically favorable nucleation and presence of cholesterol crystals in the gall bladder long enough to agglomerate into a stone...
February 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/24832105/role-of-acidic-stores-in-secretory-epithelia
#8
REVIEW
Julia Gerasimenko, Shuang Peng, Oleg Gerasimenko
There is growing evidence that intracellular calcium plays a primary role in the pathophysiology of the pancreas in addition to its crucial importance in major physiological functions. Pancreatic acinar cells have a remarkably large amount of Ca(2+) stored in both the endoplasmic reticulum (ER) and the acidic stores. The vast majority of the classical ER Ca(2+) store is located in the basal part of the acinar cells with extensions protruding into the apical area, however, the acidic stores are exclusively located in the secretory granular area of the cells...
June 2014: Cell Calcium
https://www.readbyqxmd.com/read/24548089/epidemiology-and-antimicrobial-susceptibility-of-gram-negative-aerobic-bacteria-causing-intra-abdominal-infections-during-2010-2011
#9
Stephen Hawser, Daryl J Hoban, Robert E Badal, Samuel K Bouchillon, Douglas Biedenbach, Meredith Hackel, Ian Morrissey
The study for monitoring antimicrobial resistance trends (SMART) surveillance program monitors the epidemiology and trends in antibiotic resistance of intra-abdominal pathogens to currently used therapies. The current report describes such trends during 2010-2011. A total of 25,746 Gram-negative clinical isolates from intra-abdominal infections were collected and classified as hospital-associated (HA) if the hospital length of stay (LOS) at the time of specimen collection was ≥48 hours, community-associated (CA) if LOS at the time of specimen collection was <48 hours, or unknown (no designation given by participating centre)...
February 2015: Journal of Chemotherapy
https://www.readbyqxmd.com/read/23294965/gastric-metastasis-of-cervix-uteri-carcinoma-rare-cause-of-lower-gastric-stenosis
#10
B Moldovan, E Banu, D Pocreaţă, R Buiga, S Rogoz, L Pripisi, L Cimpeanu, A Moldovan, O Jeder, A Badea, P Biris
AIM: the paper presents a rare case of metachronous gastric metastasis of uterine cervix cancer, clinically manifested through severe pyloric stenosis. METHOD: 49-year-old patient, operated on in January 2009, with uterine cervix cancer (Squamous cell carcinoma T2bN1M0), is hospitalized in August 2011 with pyloric stenosis: epigastric pains, abundant, stasis, late postprandial emesis, significant weight loss, stomach form visible upon abdomen inspection. Endoscopy: antral stenosis with intact gastric mucosa, and CT-scan: circumferential intramural gastric tumor, stomach dilated in the upper part, lack of cleavage between the tumor and the liver bed of the gall bladder...
November 2012: Chirurgia
https://www.readbyqxmd.com/read/23086920/xenin-25-increases-cytosolic-free-calcium-levels-and-acetylcholine-release-from-a-subset-of-myenteric-neurons
#11
Sheng Zhang, Krzysztof Hyrc, Songyan Wang, Burton M Wice
Xenin-25 (Xen) is a 25 amino acid neurotensin-related peptide reportedly produced with glucose-dependent insulinotropic polypeptide (GIP) by a subset of K cells in the proximal gut. We previously showed exogenously administered Xen, with GIP but not alone, increases insulin secretion in humans and mice. In mice, this effect is indirectly mediated via a central nervous system-independent cholinergic relay in the periphery. Xen also delays gastric emptying, reduces food intake, induces gall bladder contractions, and increases gut motility and secretion from the exocrine pancreas, suggesting that some effects of Xen could be mediated by myenteric neurons (MENs)...
December 15, 2012: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/23019732/-q-a-gall-bladder-lesion-with-a-high-ca19-9-blood-level
#12
Wataru Sato, Takahiro Domen, Hirohide Onishi
No abstract text is available yet for this article.
March 2012: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/22444238/68ga-nodaga-rgd-is-a-suitable-substitute-for-18-f-galacto-rgd-and-can-be-produced-with-high-specific-activity-in-a-cgmp-grp-compliant-automated-process
#13
Karolin Pohle, Johannes Notni, Johanna Bussemer, Horst Kessler, Markus Schwaiger, Ambros J Beer
INTRODUCTION: (18)F-Galacto-cyclo(RGDfK) is a well investigated tracer for imaging of ανβ3 expression in vivo, but suffers from the drawback of a time consuming multistep synthesis that can hardly be established under GMP conditions. In this study, we present a direct comparison of the pharmacokinetic properties of this tracer with (68)Ga-NODAGA-cyclo(RGDyK), in order to assess its potential as an alternative for (18)F-Galacto-cyclo(RGDfK). METHODS: (68)Ga labeling of NODAGA-cyclo(RGDyK) was done in full automation using HEPES-buffered eluate of an SnO(2) based (68)Ga-generator...
August 2012: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/22339745/percutaneous-radiofrequency-ablation-for-malignant-liver-tumours-in-challenging-locations
#14
Michalis Kelogrigoris, Fotios Laspas, Katerina Kyrkou, Kostas Stathopoulos, Vithleem Georgiadou, Loucas Thanos
PURPOSE: To evaluate the treatment results of radiofrequency ablation (RFA) for primary and metastatic malignant liver tumours in challenging locations and also to present the treatment strategy that was used in these cases. PATIENTS AND METHODS: From January 2007 to January 2010, we performed CT-guided RFA on 528 lesions in 402 patients (265 men and 137 women; mean age 65.1 years, range 19-82 years) with liver tumours (primary and metastatic) of which 98 lesions in 84 patients (55 men and 29 women; mean age 67...
February 2012: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/22216802/biomonitoring-and-biomarkers-of-organophosphate-pesticides-exposure-state-of-the-art
#15
REVIEW
Lucyna Kapka-Skrzypczak, Małgorzata Cyranka, Maciej Skrzypczak, Marcin Kruszewski
Human biomonitoring provides an efficient and cost-effective way to identify and quantify exposure to chemical substances, including those having deleterious eff ects on human organisms. Once the risk of hazardous exposure has been identified and the mechanism of toxic eff ects has been elucidated, an ultimate decision about how to reduce exposure can be made. A particularly high risk of exposure to hazardous chemicals is associated with the use of pesticides in agriculture, especially the use of organophosphorous pesticides (OP), which are the most widely and commonly used insecticides worldwide...
2011: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/21435718/aberrant-ca-2-signalling-through-acidic-calcium-stores-in-pancreatic-acinar-cells
#16
REVIEW
O H Petersen, O V Gerasimenko, A V Tepikin, J V Gerasimenko
Pancreatic acinar cells possess a very large Ca(2+) store in the endoplasmic reticulum, but also have extensive acidic Ca(2+) stores. Whereas the endoplasmic reticulum is principally located in the baso-lateral part of the cells, although with extensions into the granular area, the acidic stores are exclusively present in the apical part. The two types of stores can be differentiated pharmacologically because the endoplasmic reticulum accumulates Ca(2+) via SERCA pumps, whereas the acidic pools require functional vacuolar H(+) pumps in order to maintain a high intra-organellar Ca(2+) concentration...
August 2011: Cell Calcium
https://www.readbyqxmd.com/read/20935395/p53-carcinoembryonic-antigen-and-carbohydrate-antigen-19-9-expression-in-gall-bladder-cancer-precursor-epithelial-lesions-and-xanthogranulomatous-cholecystitis
#17
V Agrawal, A Goel, N Krishnani, R Pandey, S Agrawal, V K Kapoor
BACKGROUND: Gallbladder cancer (GBC) is the commonest gastrointestinal cancer in women of north India. Precursor epithelial lesions in GBC are known; however, the role of xanthogranulomatous (XG) inflammation in the pathogenesis of GBC is unknown. AIMS: To analyze the role of precursor lesions in the pathogenesis of GBC we studied the immunohistochemical (IHC) expression of p53, carcino-embryonic antigen (CEA) and carbohydrate antigen 19.9 (CA-19.9) in GBC, chronic cholecystitis (CC), XG cholecystitis (XGC) and precursor lesions...
October 2010: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/20079024/-intraepithelial-neoplasia-of-gall-bladder
#18
Xiao-dong Teng, Mao-de Lai
No abstract text is available yet for this article.
November 2009: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/19999207/evaluation-of-the-aetiological-spectrum-of-obstructive-jaundice
#19
Khurram Siddique, Qasim Ali, Shirin Mirza, Aiza Jamil, Aisha Ehsan, Sarmad Latif, Asif Zafar Malik
BACKGROUND: Jaundice is a common problem in medical and surgical gastroenterological practice. The surgical jaundice can be caused by the obstruction of the bile duct as with gall stones, strictures, malignancy, such as cholangiocarcinoma (in which the jaundice is persistent and progressive), periampullary carcinoma, carcinoma gall bladder and carcinoma head of pancreas. The objective of this descriptive study was to evaluate the Etiological spectrum of obstructive jaundice. METHODS: A prospective, descriptive study was carried out at Surgical Unit-II Holy family Hospital, Rawalpindi, from mid of May 2006 till March 2007...
October 2008: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/19455551/laparoscopic-robot-assisted-completion-cholecystectomy-a-report-of-three-cases
#20
Geoffrey P Kohn, John B Martinie
BACKGROUND: Gangrenous cholecystitis remains a serious, life-threatening, surgical emergency. Surgeons are occasionally forced to perform a subtotal cholecystectomy and forego formal dissection of the cystic duct and artery, in an attempt to avoid iatrogenic injury to the common bile duct. Not infrequently, a patient may develop a persistent biliary fistula or symptomatic gall bladder remnant, which may ultimately require operative intervention. METHODS: Three patients were referred to the University of North Carolina Hospitals for evaluation and treatment...
December 2009: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
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